                         SEQUENCE LISTING

<110>  CytoPathfinder, Inc.
       MIYAKE, Masato
       FUJITA, Yoshiji

<120>  COMPOUND PROFILING METHOD

<130>  CP001PCT

<150>  US 60/911,843
<151>  2007-04-13

<160>  26

<170>  PatentIn version 3.4

<210>  1
<211>  3367
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (88)..(3018)

<400>  1
gcccccgccc ggcccgcccc gctctcctag tcccttgcaa cctggcgctg ccatccgggc     60

cactgtccca ggtcccggcc cggagct atg gag cgg cgc tgg ccc ctg ggg cta    114
                              Met Glu Arg Arg Trp Pro Leu Gly Leu
                              1               5

ggg ctg gtg ctg ctg ctc tgc gcc ccg ctg ccc ccg ggg gcg cgc gcc      162
Gly Leu Val Leu Leu Leu Cys Ala Pro Leu Pro Pro Gly Ala Arg Ala
10                  15                  20                  25

aag gaa gtt act ctg atg gac aca agc aag gca cag gga gag ctg ggc      210
Lys Glu Val Thr Leu Met Asp Thr Ser Lys Ala Gln Gly Glu Leu Gly
                30                  35                  40

tgg ctg ctg gat ccc cca aaa gat ggg tgg agt gaa cag caa cag ata      258
Trp Leu Leu Asp Pro Pro Lys Asp Gly Trp Ser Glu Gln Gln Gln Ile
            45                  50                  55

ctg aat ggg aca ccc ctg tac atg tac cag gac tgc cca atg caa gga      306
Leu Asn Gly Thr Pro Leu Tyr Met Tyr Gln Asp Cys Pro Met Gln Gly
        60                  65                  70

cgc aga gac act gac cac tgg ctt cgc tcc aat tgg atc tac cgc ggg      354
Arg Arg Asp Thr Asp His Trp Leu Arg Ser Asn Trp Ile Tyr Arg Gly
    75                  80                  85

gag gag gct tcc cgc gtc cac gtg gag ctg cag ttc acc gtg cgg gac      402
Glu Glu Ala Ser Arg Val His Val Glu Leu Gln Phe Thr Val Arg Asp
90                  95                  100                 105

tgc aag agt ttc cct ggg gga gcc ggg cct ctg ggc tgc aag gag acc      450
Cys Lys Ser Phe Pro Gly Gly Ala Gly Pro Leu Gly Cys Lys Glu Thr
                110                 115                 120

ttc aac ctt ctg tac atg gag agt gac cag gat gtg ggc att cag ctc      498
Phe Asn Leu Leu Tyr Met Glu Ser Asp Gln Asp Val Gly Ile Gln Leu
            125                 130                 135

cga cgg ccc ttg ttc cag aag gta acc acg gtg gct gca gac cag agc      546
Arg Arg Pro Leu Phe Gln Lys Val Thr Thr Val Ala Ala Asp Gln Ser
        140                 145                 150

ttc acc att cga gac ctt gcg tct ggc tcc gtg aag ctg aat gtg gag      594
Phe Thr Ile Arg Asp Leu Ala Ser Gly Ser Val Lys Leu Asn Val Glu
    155                 160                 165

cgc tgc tct ctg ggc cgc ctg acc cgc cgt ggc ctc tac ctc gct ttc      642
Arg Cys Ser Leu Gly Arg Leu Thr Arg Arg Gly Leu Tyr Leu Ala Phe
170                 175                 180                 185

cac aac ccg ggt gcc tgt gtg gcc ctg gtg tct gtc cgg gtc ttc tac      690
His Asn Pro Gly Ala Cys Val Ala Leu Val Ser Val Arg Val Phe Tyr
                190                 195                 200

cag cgc tgt cct gag acc ctg aat ggc ttg gcc caa ttc cca gac act      738
Gln Arg Cys Pro Glu Thr Leu Asn Gly Leu Ala Gln Phe Pro Asp Thr
            205                 210                 215

ctg cct ggc ccc gct ggg ttg gtg gaa gtg gcg ggg acc tgc ttg ccc      786
Leu Pro Gly Pro Ala Gly Leu Val Glu Val Ala Gly Thr Cys Leu Pro
        220                 225                 230

cac gcg cgg gcc agc ccc agg ccc tca ggt gca ccc cgc atg cac tgc      834
His Ala Arg Ala Ser Pro Arg Pro Ser Gly Ala Pro Arg Met His Cys
    235                 240                 245

agc cct gat ggc gag tgg ctg gtg cct gta gga cgg tgc cac tgt gag      882
Ser Pro Asp Gly Glu Trp Leu Val Pro Val Gly Arg Cys His Cys Glu
250                 255                 260                 265

cct ggc tat gag gaa ggt ggc agt ggc gaa gca tgt gtt gcc tgc cct      930
Pro Gly Tyr Glu Glu Gly Gly Ser Gly Glu Ala Cys Val Ala Cys Pro
                270                 275                 280

agc ggc tcc tac cgg atg gac atg gac aca ccc cat tgt ctc acg tgc      978
Ser Gly Ser Tyr Arg Met Asp Met Asp Thr Pro His Cys Leu Thr Cys
            285                 290                 295

ccc cag cag agc act gct gag tct gag ggg gcc acc atc tgt acc tgt     1026
Pro Gln Gln Ser Thr Ala Glu Ser Glu Gly Ala Thr Ile Cys Thr Cys
        300                 305                 310

gag agc ggc cat tac aga gct ccc ggg gag ggc ccc cag gtg gca tgc     1074
Glu Ser Gly His Tyr Arg Ala Pro Gly Glu Gly Pro Gln Val Ala Cys
    315                 320                 325

aca ggt ccc ccc tcg gcc ccc cga aac ctg agc ttc tct gcc tca ggg     1122
Thr Gly Pro Pro Ser Ala Pro Arg Asn Leu Ser Phe Ser Ala Ser Gly
330                 335                 340                 345

act cag ctc tcc ctg cgt tgg gaa ccc cca gca gat acg ggg gga cgc     1170
Thr Gln Leu Ser Leu Arg Trp Glu Pro Pro Ala Asp Thr Gly Gly Arg
                350                 355                 360

cag gat gtc aga tac agt gtg agg tgt tcc cag tgt cag ggc aca gca     1218
Gln Asp Val Arg Tyr Ser Val Arg Cys Ser Gln Cys Gln Gly Thr Ala
            365                 370                 375

cag gac ggg ggg ccc tgc cag ccc tgt ggg gtg ggc gtg cac ttc tcg     1266
Gln Asp Gly Gly Pro Cys Gln Pro Cys Gly Val Gly Val His Phe Ser
        380                 385                 390

ccg ggg gcc cgg ggg ctc acc aca cct gca gtg cat gtc aat ggc ctt     1314
Pro Gly Ala Arg Gly Leu Thr Thr Pro Ala Val His Val Asn Gly Leu
    395                 400                 405

gaa cct tat gcc aac tac acc ttt aat gtg gaa gcc caa aat gga gtg     1362
Glu Pro Tyr Ala Asn Tyr Thr Phe Asn Val Glu Ala Gln Asn Gly Val
410                 415                 420                 425

tca ggg ctg ggc agc tct ggc cat gcc agc acc tca gtc agc atc agc     1410
Ser Gly Leu Gly Ser Ser Gly His Ala Ser Thr Ser Val Ser Ile Ser
                430                 435                 440

atg ggg cat gca gag tca ctg tca ggc ctg tct ctg aga ctg gtg aag     1458
Met Gly His Ala Glu Ser Leu Ser Gly Leu Ser Leu Arg Leu Val Lys
            445                 450                 455

aaa gaa ccg agg caa cta gag ctg acc tgg gcg ggg tcc cgg ccc cga     1506
Lys Glu Pro Arg Gln Leu Glu Leu Thr Trp Ala Gly Ser Arg Pro Arg
        460                 465                 470

agc cct ggg gcg aac ctg acc tat gag ctg cac gtg ctg aac cag gat     1554
Ser Pro Gly Ala Asn Leu Thr Tyr Glu Leu His Val Leu Asn Gln Asp
    475                 480                 485

gaa gaa cgg tac cag atg gtt cta gaa ccc agg gtc ttg ctg aca gag     1602
Glu Glu Arg Tyr Gln Met Val Leu Glu Pro Arg Val Leu Leu Thr Glu
490                 495                 500                 505

ctg cag cct gac acc aca tac atc gtc aga gtc cga atg ctg acc cca     1650
Leu Gln Pro Asp Thr Thr Tyr Ile Val Arg Val Arg Met Leu Thr Pro
                510                 515                 520

ctg ggt cct ggc cct ttc tcc cct gat cat gag ttt cgg acc agc cca     1698
Leu Gly Pro Gly Pro Phe Ser Pro Asp His Glu Phe Arg Thr Ser Pro
            525                 530                 535

cca gtg tcc agg ggc ctg act gga gga gag att gta gcc gtc atc ttt     1746
Pro Val Ser Arg Gly Leu Thr Gly Gly Glu Ile Val Ala Val Ile Phe
        540                 545                 550

ggg ctg ctg ctt ggt gca gcc ttg ctg ctt ggg att ctc gtt ttc cgg     1794
Gly Leu Leu Leu Gly Ala Ala Leu Leu Leu Gly Ile Leu Val Phe Arg
    555                 560                 565

tcc agg aga gcc cag cgg cag agg cag cag agg cag cgt gac cgc gcc     1842
Ser Arg Arg Ala Gln Arg Gln Arg Gln Gln Arg Gln Arg Asp Arg Ala
570                 575                 580                 585

acc gat gtg gat cga gag gac aag ctg tgg ctg aag cct tat gtg gac     1890
Thr Asp Val Asp Arg Glu Asp Lys Leu Trp Leu Lys Pro Tyr Val Asp
                590                 595                 600

ctc cag gca tac gag gac cct gca cag gga gcc ctg gac ttt acc cgg     1938
Leu Gln Ala Tyr Glu Asp Pro Ala Gln Gly Ala Leu Asp Phe Thr Arg
            605                 610                 615

gag ctt gat cca gcg tgg ctg atg gtg gac act gtc ata gga gaa gga     1986
Glu Leu Asp Pro Ala Trp Leu Met Val Asp Thr Val Ile Gly Glu Gly
        620                 625                 630

gag ttt ggg gaa gtg tat cga ggg acc ctg agg ctc ccc agc cag gac     2034
Glu Phe Gly Glu Val Tyr Arg Gly Thr Leu Arg Leu Pro Ser Gln Asp
    635                 640                 645

tgc aag act gtg gcc att aag acc tta aaa gac aca tcc cca ggt ggc     2082
Cys Lys Thr Val Ala Ile Lys Thr Leu Lys Asp Thr Ser Pro Gly Gly
650                 655                 660                 665

cag tgg tgg aac ttc ctt cga gag gca act atc atg ggc cag ttt agc     2130
Gln Trp Trp Asn Phe Leu Arg Glu Ala Thr Ile Met Gly Gln Phe Ser
                670                 675                 680

cac ccg cat att ctg cat ctg gaa ggc gtc gtc aca aag cga aag ccg     2178
His Pro His Ile Leu His Leu Glu Gly Val Val Thr Lys Arg Lys Pro
            685                 690                 695

atc atg atc atc aca gaa ttt atg gag aat gga gcc ctg gat gcc ttc     2226
Ile Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ala Phe
        700                 705                 710

ctg agg gag cgg gag gac cag ctg gtc cct ggg cag cta gtg gcc atg     2274
Leu Arg Glu Arg Glu Asp Gln Leu Val Pro Gly Gln Leu Val Ala Met
    715                 720                 725

ctg cag ggc ata gca tct ggc atg aac tac ctc agt aat cac aat tat     2322
Leu Gln Gly Ile Ala Ser Gly Met Asn Tyr Leu Ser Asn His Asn Tyr
730                 735                 740                 745

gtc cac cgg gac ctg gct gcc aga aac atc ttg gtg aat caa aac ctg     2370
Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Gln Asn Leu
                750                 755                 760

tgc tgc aag gtg tct gac ttt ggc ctg act cgc ctc ctg gat gac ttt     2418
Cys Cys Lys Val Ser Asp Phe Gly Leu Thr Arg Leu Leu Asp Asp Phe
            765                 770                 775

gat ggc aca tac gaa acc cag gga gga aag atc cct atc cgt tgg aca     2466
Asp Gly Thr Tyr Glu Thr Gln Gly Gly Lys Ile Pro Ile Arg Trp Thr
        780                 785                 790

gcc cct gaa gcc att gcc cat cgg atc ttc acc aca gcc agc gat gtg     2514
Ala Pro Glu Ala Ile Ala His Arg Ile Phe Thr Thr Ala Ser Asp Val
    795                 800                 805

tgg agc ttt ggg att gtg atg tgg gag gtg ctg agc ttt ggg gac aag     2562
Trp Ser Phe Gly Ile Val Met Trp Glu Val Leu Ser Phe Gly Asp Lys
810                 815                 820                 825

cct tat ggg gag atg agc aat cag gag gtt atg aag agc att gag gat     2610
Pro Tyr Gly Glu Met Ser Asn Gln Glu Val Met Lys Ser Ile Glu Asp
                830                 835                 840

ggg tac cgg ttg ccc cct cct gtg gac tgc cct gcc cct ctg tat gag     2658
Gly Tyr Arg Leu Pro Pro Pro Val Asp Cys Pro Ala Pro Leu Tyr Glu
            845                 850                 855

ctc atg aag aac tgc tgg gca tat gac cgt gcc cgc cgg cca cac ttc     2706
Leu Met Lys Asn Cys Trp Ala Tyr Asp Arg Ala Arg Arg Pro His Phe
        860                 865                 870

cag aag ctt cag gca cat ctg gag caa ctg ctt gcc aac ccc cac tcc     2754
Gln Lys Leu Gln Ala His Leu Glu Gln Leu Leu Ala Asn Pro His Ser
    875                 880                 885

ctg cgg acc att gcc aac ttt gac ccc agg atg act ctt cgc ctg ccc     2802
Leu Arg Thr Ile Ala Asn Phe Asp Pro Arg Met Thr Leu Arg Leu Pro
890                 895                 900                 905

agc ctg agt ggc tca gat ggg atc cca tat cga acc gtc tct gag tgg     2850
Ser Leu Ser Gly Ser Asp Gly Ile Pro Tyr Arg Thr Val Ser Glu Trp
                910                 915                 920

ctc gag tcc ata cgc atg aaa cgc tac atc ctg cac ttc cac tcg gct     2898
Leu Glu Ser Ile Arg Met Lys Arg Tyr Ile Leu His Phe His Ser Ala
            925                 930                 935

ggg ctg gac acc atg gag tgt gtg ctg gag ctg acc gct gag gac ctg     2946
Gly Leu Asp Thr Met Glu Cys Val Leu Glu Leu Thr Ala Glu Asp Leu
        940                 945                 950

acg cag atg gga atc aca ctg ccc ggg cac cag aag cgc att ctt tgc     2994
Thr Gln Met Gly Ile Thr Leu Pro Gly His Gln Lys Arg Ile Leu Cys
    955                 960                 965

agt att cag gga ttc aag gac tga tccctcctct caccccatgc ccaatcaggg    3048
Ser Ile Gln Gly Phe Lys Asp
970                 975

tgcaaggagc aaggacgggg ccaaggtcgc tcatggtcac tccctgcgcc ccttcccaca   3108

acctgccaga ctaggctatc ggtgctgctt ctgcccactt tcaggagaac cctgctctgc   3168

accccagaaa acctctttgt tttaaaaggg aggtgggggt agaagtaaaa ggatgatcat   3228

gggagggagc tgaggggtta atatatatac atacatacac atatatatat ttttgtaaat   3288

aaacaggaac tgattttctg cctccatccc acccatgagg gctgcaggca ctacaaaaga   3348

gctgactact gagaaaaaa                                                3367


<210>  2
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu Val Leu Leu Leu Cys
1               5                   10                  15


Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu Val Thr Leu Met Asp
            20                  25                  30


Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu Leu Asp Pro Pro Lys
        35                  40                  45


Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn Gly Thr Pro Leu Tyr
    50                  55                  60


Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg Asp Thr Asp His Trp
65                  70                  75                  80


Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu Ala Ser Arg Val His
                85                  90                  95


Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys Ser Phe Pro Gly Gly
            100                 105                 110


Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn Leu Leu Tyr Met Glu
        115                 120                 125


Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg Pro Leu Phe Gln Lys
    130                 135                 140


Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr Ile Arg Asp Leu Ala
145                 150                 155                 160


Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys Ser Leu Gly Arg Leu
                165                 170                 175


Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn Pro Gly Ala Cys Val
            180                 185                 190


Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg Cys Pro Glu Thr Leu
        195                 200                 205


Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro Gly Pro Ala Gly Leu
    210                 215                 220


Val Glu Val Ala Gly Thr Cys Leu Pro His Ala Arg Ala Ser Pro Arg
225                 230                 235                 240


Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro Asp Gly Glu Trp Leu
                245                 250                 255


Val Pro Val Gly Arg Cys His Cys Glu Pro Gly Tyr Glu Glu Gly Gly
            260                 265                 270


Ser Gly Glu Ala Cys Val Ala Cys Pro Ser Gly Ser Tyr Arg Met Asp
        275                 280                 285


Met Asp Thr Pro His Cys Leu Thr Cys Pro Gln Gln Ser Thr Ala Glu
    290                 295                 300


Ser Glu Gly Ala Thr Ile Cys Thr Cys Glu Ser Gly His Tyr Arg Ala
305                 310                 315                 320


Pro Gly Glu Gly Pro Gln Val Ala Cys Thr Gly Pro Pro Ser Ala Pro
                325                 330                 335


Arg Asn Leu Ser Phe Ser Ala Ser Gly Thr Gln Leu Ser Leu Arg Trp
            340                 345                 350


Glu Pro Pro Ala Asp Thr Gly Gly Arg Gln Asp Val Arg Tyr Ser Val
        355                 360                 365


Arg Cys Ser Gln Cys Gln Gly Thr Ala Gln Asp Gly Gly Pro Cys Gln
    370                 375                 380


Pro Cys Gly Val Gly Val His Phe Ser Pro Gly Ala Arg Gly Leu Thr
385                 390                 395                 400


Thr Pro Ala Val His Val Asn Gly Leu Glu Pro Tyr Ala Asn Tyr Thr
                405                 410                 415


Phe Asn Val Glu Ala Gln Asn Gly Val Ser Gly Leu Gly Ser Ser Gly
            420                 425                 430


His Ala Ser Thr Ser Val Ser Ile Ser Met Gly His Ala Glu Ser Leu
        435                 440                 445


Ser Gly Leu Ser Leu Arg Leu Val Lys Lys Glu Pro Arg Gln Leu Glu
    450                 455                 460


Leu Thr Trp Ala Gly Ser Arg Pro Arg Ser Pro Gly Ala Asn Leu Thr
465                 470                 475                 480


Tyr Glu Leu His Val Leu Asn Gln Asp Glu Glu Arg Tyr Gln Met Val
                485                 490                 495


Leu Glu Pro Arg Val Leu Leu Thr Glu Leu Gln Pro Asp Thr Thr Tyr
            500                 505                 510


Ile Val Arg Val Arg Met Leu Thr Pro Leu Gly Pro Gly Pro Phe Ser
        515                 520                 525


Pro Asp His Glu Phe Arg Thr Ser Pro Pro Val Ser Arg Gly Leu Thr
    530                 535                 540


Gly Gly Glu Ile Val Ala Val Ile Phe Gly Leu Leu Leu Gly Ala Ala
545                 550                 555                 560


Leu Leu Leu Gly Ile Leu Val Phe Arg Ser Arg Arg Ala Gln Arg Gln
                565                 570                 575


Arg Gln Gln Arg Gln Arg Asp Arg Ala Thr Asp Val Asp Arg Glu Asp
            580                 585                 590


Lys Leu Trp Leu Lys Pro Tyr Val Asp Leu Gln Ala Tyr Glu Asp Pro
        595                 600                 605


Ala Gln Gly Ala Leu Asp Phe Thr Arg Glu Leu Asp Pro Ala Trp Leu
    610                 615                 620


Met Val Asp Thr Val Ile Gly Glu Gly Glu Phe Gly Glu Val Tyr Arg
625                 630                 635                 640


Gly Thr Leu Arg Leu Pro Ser Gln Asp Cys Lys Thr Val Ala Ile Lys
                645                 650                 655


Thr Leu Lys Asp Thr Ser Pro Gly Gly Gln Trp Trp Asn Phe Leu Arg
            660                 665                 670


Glu Ala Thr Ile Met Gly Gln Phe Ser His Pro His Ile Leu His Leu
        675                 680                 685


Glu Gly Val Val Thr Lys Arg Lys Pro Ile Met Ile Ile Thr Glu Phe
    690                 695                 700


Met Glu Asn Gly Ala Leu Asp Ala Phe Leu Arg Glu Arg Glu Asp Gln
705                 710                 715                 720


Leu Val Pro Gly Gln Leu Val Ala Met Leu Gln Gly Ile Ala Ser Gly
                725                 730                 735


Met Asn Tyr Leu Ser Asn His Asn Tyr Val His Arg Asp Leu Ala Ala
            740                 745                 750


Arg Asn Ile Leu Val Asn Gln Asn Leu Cys Cys Lys Val Ser Asp Phe
        755                 760                 765


Gly Leu Thr Arg Leu Leu Asp Asp Phe Asp Gly Thr Tyr Glu Thr Gln
    770                 775                 780


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala His
785                 790                 795                 800


Arg Ile Phe Thr Thr Ala Ser Asp Val Trp Ser Phe Gly Ile Val Met
                805                 810                 815


Trp Glu Val Leu Ser Phe Gly Asp Lys Pro Tyr Gly Glu Met Ser Asn
            820                 825                 830


Gln Glu Val Met Lys Ser Ile Glu Asp Gly Tyr Arg Leu Pro Pro Pro
        835                 840                 845


Val Asp Cys Pro Ala Pro Leu Tyr Glu Leu Met Lys Asn Cys Trp Ala
    850                 855                 860


Tyr Asp Arg Ala Arg Arg Pro His Phe Gln Lys Leu Gln Ala His Leu
865                 870                 875                 880


Glu Gln Leu Leu Ala Asn Pro His Ser Leu Arg Thr Ile Ala Asn Phe
                885                 890                 895


Asp Pro Arg Met Thr Leu Arg Leu Pro Ser Leu Ser Gly Ser Asp Gly
            900                 905                 910


Ile Pro Tyr Arg Thr Val Ser Glu Trp Leu Glu Ser Ile Arg Met Lys
        915                 920                 925


Arg Tyr Ile Leu His Phe His Ser Ala Gly Leu Asp Thr Met Glu Cys
    930                 935                 940


Val Leu Glu Leu Thr Ala Glu Asp Leu Thr Gln Met Gly Ile Thr Leu
945                 950                 955                 960


Pro Gly His Gln Lys Arg Ile Leu Cys Ser Ile Gln Gly Phe Lys Asp
                965                 970                 975


<210>  3
<211>  3963
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (138)..(3068)

<400>  3
attaaggact cggggcagga ggggcagaag ttgcgcgcag gccggcgggc gggagcggac     60

accgaggccg gcgtgcaggc gtgcgggtgt gcgggagccg ggctcggggg gatcggaccg    120

agagcgagaa gcgcggc atg gag ctc cag gca gcc cgc gcc tgc ttc gcc       170
                   Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala
                   1               5                   10

ctg ctg tgg ggc tgt gcg ctg gcc gcg gcc gcg gcg gcg cag ggc aag      218
Leu Leu Trp Gly Cys Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys
            15                  20                  25

gaa gtg gta ctg ctg gac ttt gct gca gct gga ggg gag ctc ggc tgg      266
Glu Val Val Leu Leu Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp
        30                  35                  40

ctc aca cac ccg tat ggc aaa ggg tgg gac ctg atg cag aac atc atg      314
Leu Thr His Pro Tyr Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met
    45                  50                  55

aat gac atg ccg atc tac atg tac tcc gtg tgc aac gtg atg tct ggc      362
Asn Asp Met Pro Ile Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly
60                  65                  70                  75

gac cag gac aac tgg ctc cgc acc aac tgg gtg tac cga gga gag gct      410
Asp Gln Asp Asn Trp Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala
                80                  85                  90

gag cgt atc ttc att gag ctc aag ttt act gta cgt gac tgc aac agc      458
Glu Arg Ile Phe Ile Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser
            95                  100                 105

ttc cct ggt ggc gcc agc tcc tgc aag gag act ttc aac ctc tac tat      506
Phe Pro Gly Gly Ala Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr
        110                 115                 120

gcc gag tcg gac ctg gac tac ggc acc aac ttc cag aag cgc ctg ttc      554
Ala Glu Ser Asp Leu Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe
    125                 130                 135

acc aag att gac acc att gcg ccc gat gag atc acc gtc agc agc gac      602
Thr Lys Ile Asp Thr Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp
140                 145                 150                 155

ttc gag gca cgc cac gtg aag ctg aac gtg gag gag cgc tcc gtg ggg      650
Phe Glu Ala Arg His Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly
                160                 165                 170

ccg ctc acc cgc aaa ggc ttc tac ctg gcc ttc cag gat atc ggt gcc      698
Pro Leu Thr Arg Lys Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala
            175                 180                 185

tgt gtg gcg ctg ctc tcc gtc cgt gtc tac tac aag aag tgc ccc gag      746
Cys Val Ala Leu Leu Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu
        190                 195                 200

ctg ctg cag ggc ctg gcc cac ttc cct gag acc atc gcc ggc tct gat      794
Leu Leu Gln Gly Leu Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp
    205                 210                 215

gca cct tcc ctg gcc act gtg gcc ggc acc tgt gtg gac cat gcc gtg      842
Ala Pro Ser Leu Ala Thr Val Ala Gly Thr Cys Val Asp His Ala Val
220                 225                 230                 235

gtg cca ccg ggg ggt gaa gag ccc cgt atg cac tgt gca gtg gat ggc      890
Val Pro Pro Gly Gly Glu Glu Pro Arg Met His Cys Ala Val Asp Gly
                240                 245                 250

gag tgg ctg gtg ccc att ggg cag tgc ctg tgc cag gca ggc tac gag      938
Glu Trp Leu Val Pro Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu
            255                 260                 265

aag gtg gag gat gcc tgc cag gcc tgc tcg cct gga ttt ttt aag ttt      986
Lys Val Glu Asp Ala Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe
        270                 275                 280

gag gca tct gag agc ccc tgc ttg gag tgc cct gag cac acg ctg cca     1034
Glu Ala Ser Glu Ser Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro
    285                 290                 295

tcc cct gag ggt gcc acc tcc tgc gag tgt gag gaa ggc ttc ttc cgg     1082
Ser Pro Glu Gly Ala Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg
300                 305                 310                 315

gca cct cag gac cca gcg tcg atg cct tgc aca cga ccc ccc tcc gcc     1130
Ala Pro Gln Asp Pro Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala
                320                 325                 330

cca cac tac ctc aca gcc gtg ggc atg ggt gcc aag gtg gag ctg cgc     1178
Pro His Tyr Leu Thr Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg
            335                 340                 345

tgg acg ccc cct cag gac agc ggg ggc cgc gag gac att gtc tac agc     1226
Trp Thr Pro Pro Gln Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser
        350                 355                 360

gtc acc tgc gaa cag tgc tgg ccc gag tct ggg gaa tgc ggg ccg tgt     1274
Val Thr Cys Glu Gln Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys
    365                 370                 375

gag gcc agt gtg cgc tac tcg gag cct cct cac gga ctg acc cgc acc     1322
Glu Ala Ser Val Arg Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr
380                 385                 390                 395

agt gtg aca gtg agc gac ctg gag ccc cac atg aac tac acc ttc acc     1370
Ser Val Thr Val Ser Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr
                400                 405                 410

gtg gag gcc cgc aat ggc gtc tca ggc ctg gta acc agc cgc agc ttc     1418
Val Glu Ala Arg Asn Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe
            415                 420                 425

cgt act gcc agt gtc agc atc aac cag aca gag ccc ccc aag gtg agg     1466
Arg Thr Ala Ser Val Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg
        430                 435                 440

ctg gag ggc cgc agc acc acc tcg ctt agc gtc tcc tgg agc atc ccc     1514
Leu Glu Gly Arg Ser Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro
    445                 450                 455

ccg ccg cag cag agc cga gtg tgg aag tac gag gtc act tac cgc aag     1562
Pro Pro Gln Gln Ser Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys
460                 465                 470                 475

aag gga gac tcc aac agc tac aat gtg cgc cgc acc gag ggt ttc tcc     1610
Lys Gly Asp Ser Asn Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser
                480                 485                 490

gtg acc ctg gac gac ctg gcc cca gac acc acc tac ctg gtc cag gtg     1658
Val Thr Leu Asp Asp Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val
            495                 500                 505

cag gca ctg acg cag gag ggc cag ggg gcc ggc agc aag gtg cac gaa     1706
Gln Ala Leu Thr Gln Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu
        510                 515                 520

ttc cag acg ctg tcc ccg gag gga tct ggc aac ttg gcg gtg att ggc     1754
Phe Gln Thr Leu Ser Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly
    525                 530                 535

ggc gtg gct gtc ggt gtg gtc ctg ctt ctg gtg ctg gca gga gtt ggc     1802
Gly Val Ala Val Gly Val Val Leu Leu Leu Val Leu Ala Gly Val Gly
540                 545                 550                 555

ttc ttt atc cac cgc agg agg aag aac cag cgt gcc cgc cag tcc ccg     1850
Phe Phe Ile His Arg Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro
                560                 565                 570

gag gac gtt tac ttc tcc aag tca gaa caa ctg aag ccc ctg aag aca     1898
Glu Asp Val Tyr Phe Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr
            575                 580                 585

tac gtg gac ccc cac aca tat gag gac ccc aac cag gct gtg ttg aag     1946
Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys
        590                 595                 600

ttc act acc gag atc cat cca tcc tgt gtc act cgg cag aag gtg atc     1994
Phe Thr Thr Glu Ile His Pro Ser Cys Val Thr Arg Gln Lys Val Ile
    605                 610                 615

gga gca gga gag ttt ggg gag gtg tac aag ggc atg ctg aag aca tcc     2042
Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser
620                 625                 630                 635

tcg ggg aag aag gag gtg ccg gtg gcc atc aag acg ctg aaa gcc ggc     2090
Ser Gly Lys Lys Glu Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly
                640                 645                 650

tac aca gag aag cag cga gtg gac ttc ctc ggc gag gcc ggc atc atg     2138
Tyr Thr Glu Lys Gln Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met
            655                 660                 665

ggc cag ttc agc cac cac aac atc atc cgc cta gag ggc gtc atc tcc     2186
Gly Gln Phe Ser His His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser
        670                 675                 680

aaa tac aag ccc atg atg atc atc act gag tac atg gag aat ggg gcc     2234
Lys Tyr Lys Pro Met Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala
    685                 690                 695

ctg gac aag ttc ctt cgg gag aag gat ggc gag ttc agc gtg ctg cag     2282
Leu Asp Lys Phe Leu Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln
700                 705                 710                 715

ctg gtg ggc atg ctg cgg ggc atc gca gct ggc atg aag tac ctg gcc     2330
Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala
                720                 725                 730

aac atg aac tat gtg cac cgt gac ctg gct gcc cgc aac atc ctc gtc     2378
Asn Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val
            735                 740                 745

aac agc aac ctg gtc tgc aag gtg tct gac ttt ggc ctg tcc cgc gtg     2426
Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val
        750                 755                 760

ctg gag gac gac ccc gag gcc acc tac acc acc agt ggc ggc aag atc     2474
Leu Glu Asp Asp Pro Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile
    765                 770                 775

ccc atc cgc tgg acc gcc ccg gag gcc att tcc tac cgg aag ttc acc     2522
Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr
780                 785                 790                 795

tct gcc agc gac gtg tgg agc ttt ggc att gtc atg tgg gag gtg atg     2570
Ser Ala Ser Asp Val Trp Ser Phe Gly Ile Val Met Trp Glu Val Met
                800                 805                 810

acc tat ggc gag cgg ccc tac tgg gag ttg tcc aac cac gag gtg atg     2618
Thr Tyr Gly Glu Arg Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met
            815                 820                 825

aaa gcc atc aat gat ggc ttc cgg ctc ccc aca ccc atg gac tgc ccc     2666
Lys Ala Ile Asn Asp Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro
        830                 835                 840

tcc gcc atc tac cag ctc atg atg cag tgc tgg cag cag gag cgt gcc     2714
Ser Ala Ile Tyr Gln Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala
    845                 850                 855

cgc cgc ccc aag ttc gct gac atc gtc agc atc ctg gac aag ctc att     2762
Arg Arg Pro Lys Phe Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile
860                 865                 870                 875

cgt gcc cct gac tcc ctc aag acc ctg gct gac ttt gac ccc cgc gtg     2810
Arg Ala Pro Asp Ser Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val
                880                 885                 890

tct atc cgg ctc ccc agc acg agc ggc tcg gag ggg gtg ccc ttc cgc     2858
Ser Ile Arg Leu Pro Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg
            895                 900                 905

acg gtg tcc gag tgg ctg gag tcc atc aag atg cag cag tat acg gag     2906
Thr Val Ser Glu Trp Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu
        910                 915                 920

cac ttc atg gcg gcc ggc tac act gcc atc gag aag gtg gtg cag atg     2954
His Phe Met Ala Ala Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met
    925                 930                 935

acc aac gac gac atc aag agg att ggg gtg cgg ctg ccc ggc cac cag     3002
Thr Asn Asp Asp Ile Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln
940                 945                 950                 955

aag cgc atc gcc tac agc ctg ctg gga ctc aag gac cag gtg aac act     3050
Lys Arg Ile Ala Tyr Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr
                960                 965                 970

gtg ggg atc ccc atc tga gcctcgacag ggcctggagc cccatcggcc            3098
Val Gly Ile Pro Ile
            975

aagaatactt gaagaaacag agtggcctcc ctgctgtgcc atgctgggcc actggggact   3158

ttatttattt ctagttcttt cctccccctg caacttccgc tgaggggtct cggatgacac   3218

cctggcctga actgaggaga tgaccaggga tgctgggctg ggccctcttt ccctgcgaga   3278

cgcacacagc tgagcactta gcaggcaccg ccacgtccca gcatccctgg agcaggagcc   3338

ccgccacagc cttcggacag acatatagga tattcccaag ccgaccttcc ctccgccttc   3398

tcccacatga ggccatctca ggagatggag ggcttggccc agcgccaagt aaacagggta   3458

cctcaagccc catttcctca cactaagagg gcagactgtg aacttgactg ggtgagaccc   3518

aaagcggtcc ctgtccctct agtgccttct ttagaccctc gggccccatc ctcatccctg   3578

actggccaaa cccttgcttt cctgggcctt tgcaagatgc ttggttgtgt tgaggttttt   3638

aaatatatat tttgtacttt gtggagagaa tgtgtgtgtg tggcaggggg ccccgccagg   3698

gctggggaca gagggtgtca aacattcgtg agctggggac tcagggaccg gtgctgcagg   3758

agtgtcctgc ccatgcccca gtcggcccca tctctcatcc ttttggataa gtttctattc   3818

tgtcagtgtt aaagattttg ttttgttgga catttttttc gaatcttaat ttattatttt   3878

ttttatattt attgttagaa aatgacttat ttctgctctg gaataaagtt gcagatgatt   3938

caaaccgaaa aaaaaaaaaa aaaaa                                         3963


<210>  4
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys
1               5                   10                  15


Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu
            20                  25                  30


Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr
        35                  40                  45


Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile
    50                  55                  60


Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp
65                  70                  75                  80


Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile
                85                  90                  95


Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala
            100                 105                 110


Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu
        115                 120                 125


Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr
    130                 135                 140


Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His
145                 150                 155                 160


Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys
                165                 170                 175


Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu
            180                 185                 190


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu
        195                 200                 205


Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala
    210                 215                 220


Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly
225                 230                 235                 240


Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro
                245                 250                 255


Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala
            260                 265                 270


Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser
        275                 280                 285


Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala
    290                 295                 300


Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro
305                 310                 315                 320


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr
                325                 330                 335


Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln
            340                 345                 350


Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln
        355                 360                 365


Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg
    370                 375                 380


Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser
385                 390                 395                 400


Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn
                405                 410                 415


Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val
            420                 425                 430


Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser
        435                 440                 445


Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser
    450                 455                 460


Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn
465                 470                 475                 480


Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp
                485                 490                 495


Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln
            500                 505                 510


Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser
        515                 520                 525


Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly
    530                 535                 540


Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg
545                 550                 555                 560


Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe
                565                 570                 575


Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His
            580                 585                 590


Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile
        595                 600                 605


His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe
    610                 615                 620


Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu
625                 630                 635                 640


Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln
                645                 650                 655


Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His
            660                 665                 670


His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met
        675                 680                 685


Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu
    690                 695                 700


Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu
705                 710                 715                 720


Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val
                725                 730                 735


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val
            740                 745                 750


Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro
        755                 760                 765


Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr
    770                 775                 780


Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val
785                 790                 795                 800


Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg
                805                 810                 815


Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp
            820                 825                 830


Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln
        835                 840                 845


Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe
    850                 855                 860


Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser
865                 870                 875                 880


Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro
                885                 890                 895


Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp
            900                 905                 910


Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala
        915                 920                 925


Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile
    930                 935                 940


Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr
945                 950                 955                 960


Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile
                965                 970                 975


<210>  5
<211>  5826
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (226)..(3177)

<400>  5
cccgctctgc ttcagcgcac gctgaagacg gcactaggac ccagggaagt ccccgagcgg     60

ggttcgcgga aaggcagcca gactcctcct tatctccagt gtcaaacttg acatcagcct    120

gcgagcggag catggtaact tctccagcaa tcagagcgct ccccctcaca tcagtggcat    180

gcttcatgga gatatgctcc tctcactgcc ctctgcacca gcaac atg gat tgt cag    237
                                                  Met Asp Cys Gln
                                                  1

ctc tcc atc ctc ctc ctt ctc agc tgc tct gtt ctc gac agc ttc ggg      285
Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu Asp Ser Phe Gly
5                   10                  15                  20

gaa ctg att ccg cag cct tcc aat gaa gtc aat cta ctg gat tca aaa      333
Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu Leu Asp Ser Lys
                25                  30                  35

aca att caa ggg gag ctg ggc tgg atc tct tat cca tca cat ggg tgg      381
Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro Ser His Gly Trp
            40                  45                  50

gaa gag atc agt ggt gtg gat gaa cat tac aca ccc atc agg act tac      429
Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro Ile Arg Thr Tyr
        55                  60                  65

cag gtg tgc aat gtc atg gac cac agt caa aac aat tgg ctg aga aca      477
Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn Trp Leu Arg Thr
    70                  75                  80

aac tgg gtc ccc agg aac tca gct cag aag att tat gtg gag ctc aag      525
Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr Val Glu Leu Lys
85                  90                  95                  100

ttc act cta cga gac tgc aat agc att cca ttg gtt tta gga act tgc      573
Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val Leu Gly Thr Cys
                105                 110                 115

aag gag aca ttc aac ctg tac tac atg gag tct gat gat gat cat ggg      621
Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp Asp Asp His Gly
            120                 125                 130

gtg aaa ttt cga gag cat cag ttt aca aag att gac acc att gca gct      669
Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp Thr Ile Ala Ala
        135                 140                 145

gat gaa agt ttc act caa atg gat ctt ggg gac cgt att ctg aag ctc      717
Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg Ile Leu Lys Leu
    150                 155                 160

aac act gag att aga gaa gta ggt cct gtc aac aag aag gga ttt tat      765
Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys Lys Gly Phe Tyr
165                 170                 175                 180

ttg gca ttt caa gat gtt ggt gct tgt gtt gcc ttg gtg tct gtg aga      813
Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu Val Ser Val Arg
                185                 190                 195

gta tac ttc aaa aag tgc cca ttt aca gtg aag aat ctg gct atg ttt      861
Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn Leu Ala Met Phe
            200                 205                 210

cca gac acg gta ccc atg gac tcc cag tcc ctg gtg gag gtt aga ggg      909
Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val Glu Val Arg Gly
        215                 220                 225

tct tgt gtc aac aat tct aag gag gaa gat cct cca agg atg tac tgc      957
Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro Arg Met Tyr Cys
    230                 235                 240

agt aca gaa ggc gaa tgg ctt gta ccc att ggc aag tgt tcc tgc aat     1005
Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys Cys Ser Cys Asn
245                 250                 255                 260

gct ggc tat gaa gaa aga ggt ttt atg tgc caa gct tgt cga cca ggt     1053
Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala Cys Arg Pro Gly
                265                 270                 275

ttc tac aag gca ttg gat ggt aat atg aag tgt gct aag tgc ccg cct     1101
Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala Lys Cys Pro Pro
            280                 285                 290

cac agt tct act cag gaa gat ggt tca atg aac tgc agg tgt gag aat     1149
His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys Arg Cys Glu Asn
        295                 300                 305

aat tac ttc cgg gca gac aaa gac cct cca tcc atg gct tgt acc cga     1197
Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met Ala Cys Thr Arg
    310                 315                 320

cct cca tct tca cca aga aat gtt atc tct aat ata aac gag acc tca     1245
Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile Asn Glu Thr Ser
325                 330                 335                 340

gtt atc ctg gac tgg agt tgg ccc ctg gac aca gga ggc cgg aaa gat     1293
Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly Gly Arg Lys Asp
                345                 350                 355

gtt acc ttc aac atc ata tgt aaa aaa tgt ggg tgg aat ata aaa cag     1341
Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp Asn Ile Lys Gln
            360                 365                 370

tgt gag cca tgc agc cca aat gtc cgc ttc ctc cct cga cag ttt gga     1389
Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro Arg Gln Phe Gly
        375                 380                 385

ctc acc aac acc acg gtg aca gtg aca gac ctt ctg gca cat act aac     1437
Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu Ala His Thr Asn
    390                 395                 400

tac acc ttt gag att gat gcc gtt aat ggg gtg tca gag ctg agc tcc     1485
Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser Glu Leu Ser Ser
405                 410                 415                 420

cca cca aga cag ttt gct gcg gtc agc atc aca act aat cag gct gct     1533
Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr Asn Gln Ala Ala
                425                 430                 435

cca tca cct gtc ctg acg att aag aaa gat cgg acc tcc aga aat agc     1581
Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr Ser Arg Asn Ser
            440                 445                 450

atc tct ttg tcc tgg caa gaa cct gaa cat cct aat ggg atc ata ttg     1629
Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn Gly Ile Ile Leu
        455                 460                 465

gac tac gag gtc aaa tac tat gaa aag cag gaa caa gaa aca agt tat     1677
Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln Glu Thr Ser Tyr
    470                 475                 480

acc att ctg agg gca aga ggc aca aat gtt acc atc agt agc ctc aag     1725
Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile Ser Ser Leu Lys
485                 490                 495                 500

cct gac act ata tac gta ttc caa atc cga gcc cga aca gcc gct gga     1773
Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg Thr Ala Ala Gly
                505                 510                 515

tat ggg acg aac agc cgc aag ttt gag ttt gaa act agt cca gac tct     1821
Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr Ser Pro Asp Ser
            520                 525                 530

ttc tcc atc tct ggt gaa agt agc caa gtg gtc atg atc gcc att tca     1869
Phe Ser Ile Ser Gly Glu Ser Ser Gln Val Val Met Ile Ala Ile Ser
        535                 540                 545

gcg gca gta gca att att ctc ctc act gtt gtc atc tat gtt ttg att     1917
Ala Ala Val Ala Ile Ile Leu Leu Thr Val Val Ile Tyr Val Leu Ile
    550                 555                 560

ggg agg ttc tgt ggc tat aag tca aaa cat ggg gca gat gaa aaa aga     1965
Gly Arg Phe Cys Gly Tyr Lys Ser Lys His Gly Ala Asp Glu Lys Arg
565                 570                 575                 580

ctt cat ttt ggc aat ggg cat tta aaa ctt cca ggt ctc agg act tat     2013
Leu His Phe Gly Asn Gly His Leu Lys Leu Pro Gly Leu Arg Thr Tyr
                585                 590                 595

gtt gac cca cat aca tat gaa gac cct acc caa gct gtt cat gag ttt     2061
Val Asp Pro His Thr Tyr Glu Asp Pro Thr Gln Ala Val His Glu Phe
            600                 605                 610

gcc aag gaa ttg gat gcc acc aac ata tcc att gat aaa gtt gtt gga     2109
Ala Lys Glu Leu Asp Ala Thr Asn Ile Ser Ile Asp Lys Val Val Gly
        615                 620                 625

gca ggt gaa ttt gga gag gtg tgc agt ggt cgc tta aaa ctt cct tca     2157
Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Ser
    630                 635                 640

aaa aaa gag att tca gtg gcc att aag acc ctg aaa gtt ggc tac aca     2205
Lys Lys Glu Ile Ser Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr
645                 650                 655                 660

gaa aag cag agg aga gac ttc ctg gga gaa gca agc att atg gga cag     2253
Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser Ile Met Gly Gln
                665                 670                 675

ttt gac cac ccc aat atc att cga ctg gaa gga gtt gtt acc aaa agt     2301
Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Ser
            680                 685                 690

aag cca gtt atg att gtc aca gaa tac atg gag aat ggt tcc ttg gat     2349
Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn Gly Ser Leu Asp
        695                 700                 705

agt ttc cta cgt aaa cac gat gcc cag ttt act gtc att cag cta gtg     2397
Ser Phe Leu Arg Lys His Asp Ala Gln Phe Thr Val Ile Gln Leu Val
    710                 715                 720

ggg atg ctt cga ggg ata gca tct ggc atg aag tac ctg tca gac atg     2445
Gly Met Leu Arg Gly Ile Ala Ser Gly Met Lys Tyr Leu Ser Asp Met
725                 730                 735                 740

ggc tat gtt cac cga gac ctc gct gct cgg aac atc ttg atc aac agt     2493
Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Ile Asn Ser
                745                 750                 755

aac ttg gtg tgt aag gtt tct gat ttc gga ctt tcg cgt gtc ctg gag     2541
Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu
            760                 765                 770

gat gac cca gaa gct gct tat aca aca aga gga ggg aag atc cca atc     2589
Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly Lys Ile Pro Ile
        775                 780                 785

agg tgg aca tca cca gaa gct ata gcc tac cgc aag ttc acg tca gcc     2637
Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr Ser Ala
    790                 795                 800

agc gat gta tgg agt tat ggg att gtt ctc tgg gag gtg atg tct tat     2685
Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu Val Met Ser Tyr
805                 810                 815                 820

gga gag aga cca tac tgg gag atg tcc aat cag gat gta att aaa gct     2733
Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn Gln Asp Val Ile Lys Ala
                825                 830                 835

gta gat gag ggc tat cga ctg cca ccc ccc atg gac tgc cca gct gcc     2781
Val Asp Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro Ala Ala
            840                 845                 850

ttg tat cag ctg atg ctg gac tgc tgg cag aaa gac agg aac aac aga     2829
Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Asn Arg
        855                 860                 865

ccc aag ttt gag cag att gtt agt att ctg gac aag ctt atc cgg aat     2877
Pro Lys Phe Glu Gln Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Asn
    870                 875                 880

ccc ggc agc ctg aag atc atc acc agt gca gcc gca agg cca tca aac     2925
Pro Gly Ser Leu Lys Ile Ile Thr Ser Ala Ala Ala Arg Pro Ser Asn
885                 890                 895                 900

ctt ctt ctg gac caa agc aat gtg gat atc act acc ttc cgc aca aca     2973
Leu Leu Leu Asp Gln Ser Asn Val Asp Ile Thr Thr Phe Arg Thr Thr
                905                 910                 915

ggt gac tgg ctt aat ggt gtc tgg aca gca cac tgc aag gaa atc ttc     3021
Gly Asp Trp Leu Asn Gly Val Trp Thr Ala His Cys Lys Glu Ile Phe
            920                 925                 930

acg ggt gtg gag tac agt tct tgt gac aca ata gcc aag att tcc aca     3069
Thr Gly Val Glu Tyr Ser Ser Cys Asp Thr Ile Ala Lys Ile Ser Thr
        935                 940                 945

gat gac atg aaa aag gtt ggt gtc acc gtg gtt ggg cca cag aag aag     3117
Asp Asp Met Lys Lys Val Gly Val Thr Val Val Gly Pro Gln Lys Lys
    950                 955                 960

atc atc agt agc att aaa gct cta gaa acg caa tca aag aat ggc cca     3165
Ile Ile Ser Ser Ile Lys Ala Leu Glu Thr Gln Ser Lys Asn Gly Pro
965                 970                 975                 980

gtt ccc gtg taa agcacgggac ggaagtgctt ctggacggaa gtggtggctg         3217
Val Pro Val


tggaaggcgt agcatcatcc tgcagacaga caataattct ggagatactg gtggaagttc   3277

caagtccaat aagacactca aatatgagta caaatgcctt aaaatggaat tgaaaaactc   3337

tttattttcc cctatcattt attggatggg tgggtggggt atttttttgt aattgctttt   3397

ttaaatatta gttaatggat taaatttaat tcttcagcgt aaaatggtga agaactagca   3457

tatagccatt gatcataaac tgactatcat aaaatcaaaa caagtgaaat aacaaaatgg   3517

acatggtggc tttgtttagg tagagccaca aaagaaaaga cttgtaatat ttttatatac   3577

agaggaaatc tgtaacaggt attttgtttc ttttaaagca agcaacacag aggaatttat   3637

acctcaaact atctggccat atttactacc ttatcactgc attattctct tttatctgtt   3697

taaagcatat agagatgaag tttgtagttg ttttaagtac tacacatttt taaattgtta   3757

gcttccttaa gtatatcatg taaagaaatg tcttaatttt tgaaaaaagt acatatttat   3817

tttcttttga attgttttta ttgttttcta tttatgcctt gatgatttaa tatggatttg   3877

ttacagccaa gtgccaaatg ctctctcaaa ttgtcagcaa tttaactaga cacagataat   3937

aatgggtttc tttcagattt tttgaaccat ccacttacat atatttttaa aaaatgaaat   3997

ccttttcctg ttcatacact aaccaaatct ctcaaatctg ttatcccaat cattgttgcc   4057

tctccgttta ttataaactg tatgctcaca acttagtgta atataccagc ttgtatgcaa   4117

tggattttca accagataac atacctttcc tgctctggtg cttagagact atcaactccc   4177

tcctttagtg aaggagccgt gttagagctt ccgagaatag ctccactgga gagaagtgga   4237

atcctatata gaatgctgca ctaattgaca acacagccta taggccaatg catgagtaaa   4297

aaaaaaaaca attactggct cactggcttt gaaaagtcac ttactattgt tgctgaaact   4357

tgctgagctg tttatagaga atgatgataa cagaactttt cctctgtatc actggtgttt   4417

aggtgaatta attaaacatt gtgatcatta gtaccaggta ttattatctt taagagtctt   4477

ccacttcaat gcacatggtg cagttttggt gtgtaactta gaaggattga acttctttga   4537

atttactgga cataacattt tcagaatagt tggtcatcta gcaaccgcct caaaatgtgt   4597

aagcaggaga gaaatttctc atcacaggga tttagactta ctattacata aaggctaact   4657

atgagcttgc tcattaattt tgaaaagatg tacctggtgg atatctagct agtaatatat   4717

tctgaagcaa cattttagct ctattgatac tctttctaat gctgatatga tcttgagtat   4777

aagaaatgca tatgtcacta gaatggataa aataatgctg caaacttaat gttcttatgc   4837

aaaatggaac gctaatgaaa cacagcttac aatcgcaaat caaaactcac aagtgctcat   4897

ctgttgtaga tttagtgtaa taagacttag attgtgctcc ttcggatatg attgtttctc   4957

aaatcttggc aatattcctt agtcaaatca ggctactaga attctgtatt ggatatataa   5017

gagcatgaaa tttttaaaaa tacacttgtg attataaaat taatcacaaa tttcacttat   5077

acctgctatc agcagctaga aaacattttt tttttaaatc aagtattttg tgtttggaat   5137

gttagaatga gatctgaatg tggtttcaat ctaatttttt cccagactac tattttcttt   5197

tttaggtact attctgagca tactcaacaa aacccatgca tttcataaac taatagaagt   5257

tgaggattgt tgaatctatt tcacttattt tggctgtggt ttccatctga aagtagaggt   5317

tgtatacacc atatactgtt cttcatttta ttaatatttt tctccttgac ctctcataaa   5377

tttactttac acaattctta ccctgtacat atgtaaacat aagtgtacga ttcttaacca   5437

tggagtagag gtactagaat gcttacggcc atctctttgt acaggaactg cattgacttt   5497

cagtaaacat aaagccacaa ctcctacatg atgttatgta ccatatgatc tgttttgtat   5557

cttaaatttg atttacatat attatttatt tctggtaact cactcagttt atgctgtgct   5617

aaatatcaat caagccatgt ataaatgtga tatgattggc aatatgtgtt tactttaaac   5677

ttgtcttttc aaaatattac tcagtttatg ttgtacaatg tagatggcct cttactaatg   5737

taaaatgatt tgtagtggaa acatttatat ttttataata aacataatga aaatattttt   5797

tacagattgg aaaaaaaaaa aaaaaaaaa                                     5826


<210>  6
<211>  983
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Cys Gln Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu
1               5                   10                  15


Asp Ser Phe Gly Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu
            20                  25                  30


Leu Asp Ser Lys Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro
        35                  40                  45


Ser His Gly Trp Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro
    50                  55                  60


Ile Arg Thr Tyr Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn
65                  70                  75                  80


Trp Leu Arg Thr Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr
                85                  90                  95


Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val
            100                 105                 110


Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp
        115                 120                 125


Asp Asp His Gly Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp
    130                 135                 140


Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg
145                 150                 155                 160


Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys
                165                 170                 175


Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu
            180                 185                 190


Val Ser Val Arg Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn
        195                 200                 205


Leu Ala Met Phe Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val
    210                 215                 220


Glu Val Arg Gly Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro
225                 230                 235                 240


Arg Met Tyr Cys Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys
                245                 250                 255


Cys Ser Cys Asn Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala
            260                 265                 270


Cys Arg Pro Gly Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala
        275                 280                 285


Lys Cys Pro Pro His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys
    290                 295                 300


Arg Cys Glu Asn Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met
305                 310                 315                 320


Ala Cys Thr Arg Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile
                325                 330                 335


Asn Glu Thr Ser Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly
            340                 345                 350


Gly Arg Lys Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp
        355                 360                 365


Asn Ile Lys Gln Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro
    370                 375                 380


Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu
385                 390                 395                 400


Ala His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser
                405                 410                 415


Glu Leu Ser Ser Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr
            420                 425                 430


Asn Gln Ala Ala Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr
        435                 440                 445


Ser Arg Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn
    450                 455                 460


Gly Ile Ile Leu Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln
465                 470                 475                 480


Glu Thr Ser Tyr Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile
                485                 490                 495


Ser Ser Leu Lys Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg
            500                 505                 510


Thr Ala Ala Gly Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr
        515                 520                 525


Ser Pro Asp Ser Phe Ser Ile Ser Gly Glu Ser Ser Gln Val Val Met
    530                 535                 540


Ile Ala Ile Ser Ala Ala Val Ala Ile Ile Leu Leu Thr Val Val Ile
545                 550                 555                 560


Tyr Val Leu Ile Gly Arg Phe Cys Gly Tyr Lys Ser Lys His Gly Ala
                565                 570                 575


Asp Glu Lys Arg Leu His Phe Gly Asn Gly His Leu Lys Leu Pro Gly
            580                 585                 590


Leu Arg Thr Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Thr Gln Ala
        595                 600                 605


Val His Glu Phe Ala Lys Glu Leu Asp Ala Thr Asn Ile Ser Ile Asp
    610                 615                 620


Lys Val Val Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu
625                 630                 635                 640


Lys Leu Pro Ser Lys Lys Glu Ile Ser Val Ala Ile Lys Thr Leu Lys
                645                 650                 655


Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser
            660                 665                 670


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val
        675                 680                 685


Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn
    690                 695                 700


Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Ala Gln Phe Thr Val
705                 710                 715                 720


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met Lys Tyr
                725                 730                 735


Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile
            740                 745                 750


Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser
        755                 760                 765


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly
    770                 775                 780


Lys Ile Pro Ile Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys
785                 790                 795                 800


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu
                805                 810                 815


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn Gln Asp
            820                 825                 830


Val Ile Lys Ala Val Asp Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp
        835                 840                 845


Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Asp
    850                 855                 860


Arg Asn Asn Arg Pro Lys Phe Glu Gln Ile Val Ser Ile Leu Asp Lys
865                 870                 875                 880


Leu Ile Arg Asn Pro Gly Ser Leu Lys Ile Ile Thr Ser Ala Ala Ala
                885                 890                 895


Arg Pro Ser Asn Leu Leu Leu Asp Gln Ser Asn Val Asp Ile Thr Thr
            900                 905                 910


Phe Arg Thr Thr Gly Asp Trp Leu Asn Gly Val Trp Thr Ala His Cys
        915                 920                 925


Lys Glu Ile Phe Thr Gly Val Glu Tyr Ser Ser Cys Asp Thr Ile Ala
    930                 935                 940


Lys Ile Ser Thr Asp Asp Met Lys Lys Val Gly Val Thr Val Val Gly
945                 950                 955                 960


Pro Gln Lys Lys Ile Ile Ser Ser Ile Lys Ala Leu Glu Thr Gln Ser
                965                 970                 975


Lys Asn Gly Pro Val Pro Val
            980


<210>  7
<211>  6364
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (43)..(3003)

<400>  7
ctgggataga agcggcagga gcagcgttgg caccggcgaa cc atg gct ggg att        54
                                               Met Ala Gly Ile
                                               1

ttc tat ttc gcc cta ttt tcg tgt ctc ttc ggg att tgc gac gct gtc      102
Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile Cys Asp Ala Val
5                   10                  15                  20

aca ggt tcc agg gta tac ccc gcg aat gaa gtt acc tta ttg gat tcc      150
Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr Leu Leu Asp Ser
                25                  30                  35

aga tct gtt cag gga gaa ctt ggg tgg ata gca agc cct ctg gaa gga      198
Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser Pro Leu Glu Gly
            40                  45                  50

ggg tgg gag gaa gtg agt atc atg gat gaa aaa aat aca cca atc cga      246
Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn Thr Pro Ile Arg
        55                  60                  65

acc tac caa gtg tgc aat gtg atg gaa ccc agc cag aat aac tgg cta      294
Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln Asn Asn Trp Leu
    70                  75                  80

cga act gat tgg atc acc cga gaa ggg gct cag agg gtg tat att gag      342
Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg Val Tyr Ile Glu
85                  90                  95                  100

att aaa ttc acc ttg agg gac tgc aat agt ctt ccg ggc gtc atg ggg      390
Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro Gly Val Met Gly
                105                 110                 115

act tgc aag gag acg ttt aac ctg tac tac tat gaa tca gac aac gac      438
Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu Ser Asp Asn Asp
            120                 125                 130

aaa gag cgt ttc atc aga gag aac cag ttt gtc aaa att gac acc att      486
Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys Ile Asp Thr Ile
        135                 140                 145

gct gct gat gag agc ttc acc caa gtg gac att ggt gac aga atc atg      534
Ala Ala Asp Glu Ser Phe Thr Gln Val Asp Ile Gly Asp Arg Ile Met
    150                 155                 160

aag ctg aac acc gag atc cgg gat gta ggg cca tta agc aaa aag ggg      582
Lys Leu Asn Thr Glu Ile Arg Asp Val Gly Pro Leu Ser Lys Lys Gly
165                 170                 175                 180

ttt tac ctg gct ttt cag gat gtg ggg gcc tgc atc gcc ctg gta tca      630
Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile Ala Leu Val Ser
                185                 190                 195

gtc cgt gtg ttc tat aaa aag tgt cca ctc aca gtc cgc aat ctg gcc      678
Val Arg Val Phe Tyr Lys Lys Cys Pro Leu Thr Val Arg Asn Leu Ala
            200                 205                 210

cag ttt cct gac acc atc aca ggg gct gat acg tct tcc ctg gtg gaa      726
Gln Phe Pro Asp Thr Ile Thr Gly Ala Asp Thr Ser Ser Leu Val Glu
        215                 220                 225

gtt cga ggc tcc tgt gtc aac aac tca gaa gag aaa gat gtg cca aaa      774
Val Arg Gly Ser Cys Val Asn Asn Ser Glu Glu Lys Asp Val Pro Lys
    230                 235                 240

atg tac tgt ggg gca gat ggt gaa tgg ctg gta ccc att ggc aac tgc      822
Met Tyr Cys Gly Ala Asp Gly Glu Trp Leu Val Pro Ile Gly Asn Cys
245                 250                 255                 260

cta tgc aac gct ggg cat gag gag cgg agc gga gaa tgc caa gct tgc      870
Leu Cys Asn Ala Gly His Glu Glu Arg Ser Gly Glu Cys Gln Ala Cys
                265                 270                 275

aaa att gga tat tac aag gct ctc tcc acg gat gcc acc tgt gcc aag      918
Lys Ile Gly Tyr Tyr Lys Ala Leu Ser Thr Asp Ala Thr Cys Ala Lys
            280                 285                 290

tgc cca ccc cac agc tac tct gtc tgg gaa gga gcc acc tcg tgc acc      966
Cys Pro Pro His Ser Tyr Ser Val Trp Glu Gly Ala Thr Ser Cys Thr
        295                 300                 305

tgt gac cga ggc ttt ttc aga gct gac aac gat gct gcc tct atg ccc     1014
Cys Asp Arg Gly Phe Phe Arg Ala Asp Asn Asp Ala Ala Ser Met Pro
    310                 315                 320

tgc acc cgt cca cca tct gct ccc ctg aac ttg att tca aat gtc aac     1062
Cys Thr Arg Pro Pro Ser Ala Pro Leu Asn Leu Ile Ser Asn Val Asn
325                 330                 335                 340

gag aca tct gtg aac ttg gaa tgg agt agc cct cag aat aca ggt ggc     1110
Glu Thr Ser Val Asn Leu Glu Trp Ser Ser Pro Gln Asn Thr Gly Gly
                345                 350                 355

cgc cag gac att tcc tat aat gtg gta tgc aag aaa tgt gga gct ggt     1158
Arg Gln Asp Ile Ser Tyr Asn Val Val Cys Lys Lys Cys Gly Ala Gly
            360                 365                 370

gac ccc agc aag tgc cga ccc tgt gga agt ggg gtc cac tac acc cca     1206
Asp Pro Ser Lys Cys Arg Pro Cys Gly Ser Gly Val His Tyr Thr Pro
        375                 380                 385

cag cag aat ggc ttg aag acc acc aaa gtc tcc atc act gac ctc cta     1254
Gln Gln Asn Gly Leu Lys Thr Thr Lys Val Ser Ile Thr Asp Leu Leu
    390                 395                 400

gct cat acc aat tac acc ttt gaa atc tgg gct gtg aat gga gtg tcc     1302
Ala His Thr Asn Tyr Thr Phe Glu Ile Trp Ala Val Asn Gly Val Ser
405                 410                 415                 420

aaa tat aac cct aac cca gac caa tca gtt tct gtc act gtg acc acc     1350
Lys Tyr Asn Pro Asn Pro Asp Gln Ser Val Ser Val Thr Val Thr Thr
                425                 430                 435

aac caa gca gca cca tca tcc att gct ttg gtc cag gct aaa gaa gtc     1398
Asn Gln Ala Ala Pro Ser Ser Ile Ala Leu Val Gln Ala Lys Glu Val
            440                 445                 450

aca aga tac agt gtg gca ctg gct tgg ctg gaa cca gat cgg ccc aat     1446
Thr Arg Tyr Ser Val Ala Leu Ala Trp Leu Glu Pro Asp Arg Pro Asn
        455                 460                 465

ggg gta atc ctg gaa tat gaa gtc aag tat tat gag aag gat cag aat     1494
Gly Val Ile Leu Glu Tyr Glu Val Lys Tyr Tyr Glu Lys Asp Gln Asn
    470                 475                 480

gag cga agc tat cgt ata gtt cgg aca gct gcc agg aac aca gat atc     1542
Glu Arg Ser Tyr Arg Ile Val Arg Thr Ala Ala Arg Asn Thr Asp Ile
485                 490                 495                 500

aaa ggc ctg aac cct ctc act tcc tat gtt ttc cac gtg cga gcc agg     1590
Lys Gly Leu Asn Pro Leu Thr Ser Tyr Val Phe His Val Arg Ala Arg
                505                 510                 515

aca gca gct ggc tat gga gac ttc agt gag ccc ttg gag gtt aca acc     1638
Thr Ala Ala Gly Tyr Gly Asp Phe Ser Glu Pro Leu Glu Val Thr Thr
            520                 525                 530

aac aca gtg cct tcc cgg atc att gga gat ggg gct aac tcc aca gtc     1686
Asn Thr Val Pro Ser Arg Ile Ile Gly Asp Gly Ala Asn Ser Thr Val
        535                 540                 545

ctt ctg gtc tct gtc tcg ggc agt gtg gtg ctg gtg gta att ctc att     1734
Leu Leu Val Ser Val Ser Gly Ser Val Val Leu Val Val Ile Leu Ile
    550                 555                 560

gca gct ttt gtc atc agc cgg aga cgg agt aaa tac agt aaa gcc aaa     1782
Ala Ala Phe Val Ile Ser Arg Arg Arg Ser Lys Tyr Ser Lys Ala Lys
565                 570                 575                 580

caa gaa gcg gat gaa gag aaa cat ttg aat caa ggt gta aga aca tat     1830
Gln Glu Ala Asp Glu Glu Lys His Leu Asn Gln Gly Val Arg Thr Tyr
                585                 590                 595

gtg gac ccc ttt acg tac gaa gat ccc aac caa gca gtg cga gag ttt     1878
Val Asp Pro Phe Thr Tyr Glu Asp Pro Asn Gln Ala Val Arg Glu Phe
            600                 605                 610

gcc aaa gaa att gac gca tcc tgc att aag att gaa aaa gtt ata gga     1926
Ala Lys Glu Ile Asp Ala Ser Cys Ile Lys Ile Glu Lys Val Ile Gly
        615                 620                 625

gtt ggt gaa ttt ggt gag gta tgc agt ggg cgt ctc aaa gtg cct ggc     1974
Val Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu Lys Val Pro Gly
    630                 635                 640

aag aga gag atc tgt gtg gct atc aag act ctg aaa gct ggt tat aca     2022
Lys Arg Glu Ile Cys Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr
645                 650                 655                 660

gac aaa cag agg aga gac ttc ctg agt gag gcc agc atc atg gga cag     2070
Asp Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln
                665                 670                 675

ttt gac cat ccg aac atc att cac ttg gaa ggc gtg gtc act aaa tgt     2118
Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val Val Thr Lys Cys
            680                 685                 690

aaa cca gta atg atc ata aca gag tac atg gag aat ggc tcc ttg gat     2166
Lys Pro Val Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ser Leu Asp
        695                 700                 705

gca ttc ctc agg aaa aat gat ggc aga ttt aca gtc att cag ctg gtg     2214
Ala Phe Leu Arg Lys Asn Asp Gly Arg Phe Thr Val Ile Gln Leu Val
    710                 715                 720

ggc atg ctt cgt ggc att ggg tct ggg atg aag tat tta tct gat atg     2262
Gly Met Leu Arg Gly Ile Gly Ser Gly Met Lys Tyr Leu Ser Asp Met
725                 730                 735                 740

agc tat gtg cat cgt gat ctg gcc gca cgg aac atc ctg gtg aac agc     2310
Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser
                745                 750                 755

aac ttg gtc tgc aaa gtg tct gat ttt ggc atg tcc cga gtg ctt gag     2358
Asn Leu Val Cys Lys Val Ser Asp Phe Gly Met Ser Arg Val Leu Glu
            760                 765                 770

gat gat ccg gaa gca gct tac acc acc agg ggt ggc aag att cct atc     2406
Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly Lys Ile Pro Ile
        775                 780                 785

cgg tgg act gcg cca gaa gca att gcc tat cgt aaa ttc aca tca gca     2454
Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr Ser Ala
    790                 795                 800

agt gat gta tgg agc tat gga atc gtt atg tgg gaa gtg atg tcg tac     2502
Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr
805                 810                 815                 820

ggg gag agg ccc tat tgg gat atg tcc aat caa gat gtg att aaa gcc     2550
Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Lys Ala
                825                 830                 835

att gag gaa ggc tat cgg tta ccc cct cca atg gac tgc ccc att gcg     2598
Ile Glu Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro Ile Ala
            840                 845                 850

ctc cac cag ctg atg cta gac tgc tgg cag aag gag agg agc gac agg     2646
Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu Arg Ser Asp Arg
        855                 860                 865

cct aaa ttt ggg cag att gtc aac atg ttg gac aaa ctc atc cgc aac     2694
Pro Lys Phe Gly Gln Ile Val Asn Met Leu Asp Lys Leu Ile Arg Asn
    870                 875                 880

ccc aac agc ttg aag agg aca ggg acg gag agc tcc aga cct aac act     2742
Pro Asn Ser Leu Lys Arg Thr Gly Thr Glu Ser Ser Arg Pro Asn Thr
885                 890                 895                 900

gcc ttg ttg gat cca agc tcc cct gaa ttc tct gct gtg gta tca gtg     2790
Ala Leu Leu Asp Pro Ser Ser Pro Glu Phe Ser Ala Val Val Ser Val
                905                 910                 915

ggc gat tgg ctc cag gcc att aaa atg gac cgg tat aag gat aac ttc     2838
Gly Asp Trp Leu Gln Ala Ile Lys Met Asp Arg Tyr Lys Asp Asn Phe
            920                 925                 930

aca gct gct ggt tat acc aca cta gag gct gtg gtg cac gtg aac cag     2886
Thr Ala Ala Gly Tyr Thr Thr Leu Glu Ala Val Val His Val Asn Gln
        935                 940                 945

gag gac ctg gca aga att ggt atc aca gcc atc acg cac cag aat aag     2934
Glu Asp Leu Ala Arg Ile Gly Ile Thr Ala Ile Thr His Gln Asn Lys
    950                 955                 960

att ttg agc agt gtc cag gca atg cga acc caa atg cag cag atg cac     2982
Ile Leu Ser Ser Val Gln Ala Met Arg Thr Gln Met Gln Gln Met His
965                 970                 975                 980

ggc aga atg gtt ccc gtc tga gccagtactg aataaactca aaactcttga        3033
Gly Arg Met Val Pro Val
                985

aattagttta cctcatccat gcactttaat tgaagaactg cacttttttt acttcgtctt   3093

cgccctctga aattaaagaa atgaaaaaaa aaaacaatat ctgcagcgtt gcttggtgca   3153

cagattgctg aaactgtggg gcttacagaa atgactgccg gtcatttgaa tgagacctgg   3213

aacaaatcgt ttctcagaag tacttttctg ttcatcacca gtctgtaaaa tacatgtacc   3273

tatagaaata gaacactgcc tctgagtttt gatgctgtat ttgctgccag acactgagct   3333

tctgagacat ccctgattct ctctccattt ggaattacaa ccattgtatt ttgtttgtgg   3393

cataaattac agtcatctgt ctttcactgg aatgaagacc atgcctagga acatttttta   3453

aggactcagc tgtggctttt agggcttggt tcataccatg ggggaaaaaa aagtcctagg   3513

agaaagcgac gtggctcatt agtgttgcct cttcagtgct caagccgcct ggtggattcc   3573

tatgacacag ggggcctgga aagaaaggga aagtggattt aaaatatata tatacgtaac   3633

ccaagcccca taacccctaa ctggacaaat gaggtctgtt tctttgggcc tgaggctgtg   3693

ccatataaag tcttattttg ggactttaca aacttgtcct aactatcttg tggatagtgg   3753

gctgtgacaa tctggaatag agaacgttca cacttcgctc ctttaaagaa gcgaccccag   3813

atctgcaagg gagtagattc tgctatcttg gcctcacagc ccttcctgtt gattacaaag   3873

cccgtggaag aaaacagaac acaccctcct cagttccgtc taaatgtgtt tcttctgctt   3933

caattacacc agttctgggg caaagacact gatgaaacaa cacccatacc tgaaaagaat   3993

aaatgtgtga ctttcaaatc ccctttcgca gtgaaagaaa cagcaaacac ttaagattca   4053

gcatctgttc tccagttgca ctgaggaatg cactgtctcg cagcaccagc tctgcagagc   4113

ccttgcccca gactctttgc ggttttattt atatgtattt ccatatttca ttcctgtgtg   4173

tcactgctgc attggtgtgg cagcaagtga ccaaatgcta caggtcttac tatggacacc   4233

aggtcaggtg caaccacaca aaacaaagcc agttccatga gctgcctatg atatgcattg   4293

cggaagtaac attttaccca gggtgtgcca ttgcagtgat ataaatatat ttttttctta   4353

gactaaatat gagctgacta tctcttttga tgtgtgtaca taggtgtgag tgtgtgtgta   4413

tgcgtgcctg tctgtgtgcg ggtgtgtgta tgtgcatagc ctcatgctta ggactaccca   4473

tgaatgttgt ggaatgctac acctggagag ttctggtttt ccaccagttt caagatgaag   4533

aactacatga tacagtggac ctggagacca tccccttgga aagacaaccc agagatgttc   4593

agcatcctgt atctacacgc atcctgtatc tacacgtgta ttttgtagct gtcacactaa   4653

ccttaataag aattctacag ctttggacag aggcattttc accttaatgg tgaagtaatt   4713

taaaatataa atccattcag gtgacaaccc atcatcaaaa ttacaaattt tctgattgaa   4773

ctcatctgaa tcatcagttc cttgatggag agagagaagg agatggaatg tgtctggtaa   4833

ccccaaatgg agtacaagta gcctttgttt tcctgcataa atggacttgt tgaatgcgaa   4893

cgaatatatg caattcatat acttttggag atgaacgtag atatgtgtgt cagctttgag   4953

atggtgtgtc ctggattaat actttgtctc ccaatatcac agaaaaatac atgccagtga   5013

ctcttgaggt taaggtagtt gggatgaaat ggcctcaggc aatttcacat tccctaatta   5073

cctggaaagt tctacagtaa ttaatatgca gctaactcct gttgccctca caagagcatc   5133

agccttctag aatcggagct ccggagtgtg aagattcagt attgatatga tatgtatacc   5193

aaactccagc caacttactg ccatttttca taatctgagt ggctgccttg cttatcctaa   5253

gctgtggttg cagaaaccgt ggccatttat ataagctata acatcaaatc agggaaaaat   5313

gaggaaaaaa aatagattct gaaccattta ttgttgaata agtagagaaa atcatcaata   5373

aatatttatt acattctgac agggtgtgtg gcattgtgtt ctatgccaga gtgacaaagt   5433

tgattcaccc ctttttgggg accttaatat attttttaag ggatgtgcct atgcattgat   5493

gcctgaaaaa tatgtataaa gaaatgaggt tgactcttct gagcagttca tcttttccag   5553

aggtaagggt aggaggccaa cttcagggtc tgggtctgag cccgtgggca agccctggcc   5613

gagtgagctc caatgctaac tcatgtgccg atctctagag cagtgggaaa ctaccccgct   5673

gcaccaaatc aagtagcttc accttgtgta tgcaggcccc aagttatttt ttagcaatct   5733

tacgagtgaa atgttctggt gggttgaaaa acgttcttat tttaaagaaa ggttgtgctc   5793

gctacactgc tggtgtgtgc attctgagac ctcttgtatt caatctgtga aggatatgtg   5853

tattaatccg tacacccgta tagcctcaat atttgtctga agacacttaa attctgaccc   5913

ataaaggaaa gttctagaag caatattttc acttatttaa cattctccaa acaacatcaa   5973

gcattgatac acactgaaga gtgcgtttat tttttgtatc actctaagta tgttggaata   6033

tgcaaggact gtggttcaaa ttagaatgta taaggcatat tataatttag ttcatactga   6093

ataagaaatt aacagaacat tgttcggttc acacgttcca aactttgagt gatttctgga   6153

gttagacata gattttctat tttgttttaa tttgtcaagg tatttttctt cccttcatga   6213

actttaggta cacataactt atgtcattta tttatggtct tttataccta gtttgtaaaa   6273

ttgtaaaata gcaaactaaa tgcaaagagt ttgcatttga aaataataaa gtagttgccg   6333

tatacaaccc tgcaaaaaaa aaaaaaaaaa a                                  6364


<210>  8
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile
1               5                   10                  15


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr
            20                  25                  30


Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser
        35                  40                  45


Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn
    50                  55                  60


Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln
65                  70                  75                  80


Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg
                85                  90                  95


Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro
            100                 105                 110


Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu
        115                 120                 125


Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys
    130                 135                 140


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Val Asp Ile Gly
145                 150                 155                 160


Asp Arg Ile Met Lys Leu Asn Thr Glu Ile Arg Asp Val Gly Pro Leu
                165                 170                 175


Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile
            180                 185                 190


Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Leu Thr Val
        195                 200                 205


Arg Asn Leu Ala Gln Phe Pro Asp Thr Ile Thr Gly Ala Asp Thr Ser
    210                 215                 220


Ser Leu Val Glu Val Arg Gly Ser Cys Val Asn Asn Ser Glu Glu Lys
225                 230                 235                 240


Asp Val Pro Lys Met Tyr Cys Gly Ala Asp Gly Glu Trp Leu Val Pro
                245                 250                 255


Ile Gly Asn Cys Leu Cys Asn Ala Gly His Glu Glu Arg Ser Gly Glu
            260                 265                 270


Cys Gln Ala Cys Lys Ile Gly Tyr Tyr Lys Ala Leu Ser Thr Asp Ala
        275                 280                 285


Thr Cys Ala Lys Cys Pro Pro His Ser Tyr Ser Val Trp Glu Gly Ala
    290                 295                 300


Thr Ser Cys Thr Cys Asp Arg Gly Phe Phe Arg Ala Asp Asn Asp Ala
305                 310                 315                 320


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro Leu Asn Leu Ile
                325                 330                 335


Ser Asn Val Asn Glu Thr Ser Val Asn Leu Glu Trp Ser Ser Pro Gln
            340                 345                 350


Asn Thr Gly Gly Arg Gln Asp Ile Ser Tyr Asn Val Val Cys Lys Lys
        355                 360                 365


Cys Gly Ala Gly Asp Pro Ser Lys Cys Arg Pro Cys Gly Ser Gly Val
    370                 375                 380


His Tyr Thr Pro Gln Gln Asn Gly Leu Lys Thr Thr Lys Val Ser Ile
385                 390                 395                 400


Thr Asp Leu Leu Ala His Thr Asn Tyr Thr Phe Glu Ile Trp Ala Val
                405                 410                 415


Asn Gly Val Ser Lys Tyr Asn Pro Asn Pro Asp Gln Ser Val Ser Val
            420                 425                 430


Thr Val Thr Thr Asn Gln Ala Ala Pro Ser Ser Ile Ala Leu Val Gln
        435                 440                 445


Ala Lys Glu Val Thr Arg Tyr Ser Val Ala Leu Ala Trp Leu Glu Pro
    450                 455                 460


Asp Arg Pro Asn Gly Val Ile Leu Glu Tyr Glu Val Lys Tyr Tyr Glu
465                 470                 475                 480


Lys Asp Gln Asn Glu Arg Ser Tyr Arg Ile Val Arg Thr Ala Ala Arg
                485                 490                 495


Asn Thr Asp Ile Lys Gly Leu Asn Pro Leu Thr Ser Tyr Val Phe His
            500                 505                 510


Val Arg Ala Arg Thr Ala Ala Gly Tyr Gly Asp Phe Ser Glu Pro Leu
        515                 520                 525


Glu Val Thr Thr Asn Thr Val Pro Ser Arg Ile Ile Gly Asp Gly Ala
    530                 535                 540


Asn Ser Thr Val Leu Leu Val Ser Val Ser Gly Ser Val Val Leu Val
545                 550                 555                 560


Val Ile Leu Ile Ala Ala Phe Val Ile Ser Arg Arg Arg Ser Lys Tyr
                565                 570                 575


Ser Lys Ala Lys Gln Glu Ala Asp Glu Glu Lys His Leu Asn Gln Gly
            580                 585                 590


Val Arg Thr Tyr Val Asp Pro Phe Thr Tyr Glu Asp Pro Asn Gln Ala
        595                 600                 605


Val Arg Glu Phe Ala Lys Glu Ile Asp Ala Ser Cys Ile Lys Ile Glu
    610                 615                 620


Lys Val Ile Gly Val Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu
625                 630                 635                 640


Lys Val Pro Gly Lys Arg Glu Ile Cys Val Ala Ile Lys Thr Leu Lys
                645                 650                 655


Ala Gly Tyr Thr Asp Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser
            660                 665                 670


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val
        675                 680                 685


Val Thr Lys Cys Lys Pro Val Met Ile Ile Thr Glu Tyr Met Glu Asn
    690                 695                 700


Gly Ser Leu Asp Ala Phe Leu Arg Lys Asn Asp Gly Arg Phe Thr Val
705                 710                 715                 720


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Gly Ser Gly Met Lys Tyr
                725                 730                 735


Leu Ser Asp Met Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile
            740                 745                 750


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Met Ser
        755                 760                 765


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly
    770                 775                 780


Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys
785                 790                 795                 800


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu
                805                 810                 815


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp
            820                 825                 830


Val Ile Lys Ala Ile Glu Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp
        835                 840                 845


Cys Pro Ile Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu
    850                 855                 860


Arg Ser Asp Arg Pro Lys Phe Gly Gln Ile Val Asn Met Leu Asp Lys
865                 870                 875                 880


Leu Ile Arg Asn Pro Asn Ser Leu Lys Arg Thr Gly Thr Glu Ser Ser
                885                 890                 895


Arg Pro Asn Thr Ala Leu Leu Asp Pro Ser Ser Pro Glu Phe Ser Ala
            900                 905                 910


Val Val Ser Val Gly Asp Trp Leu Gln Ala Ile Lys Met Asp Arg Tyr
        915                 920                 925


Lys Asp Asn Phe Thr Ala Ala Gly Tyr Thr Thr Leu Glu Ala Val Val
    930                 935                 940


His Val Asn Gln Glu Asp Leu Ala Arg Ile Gly Ile Thr Ala Ile Thr
945                 950                 955                 960


His Gln Asn Lys Ile Leu Ser Ser Val Gln Ala Met Arg Thr Gln Met
                965                 970                 975


Gln Gln Met His Gly Arg Met Val Pro Val
            980                 985


<210>  9
<211>  5229
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (214)..(3210)

<400>  9
gcagtcggag acttgcaggc agcaaacacg gtgcgagcga acaggagtgg gggggaaatt     60

aaaaaaagct aaacgtggag cagccgatcg gggaccgaga aggggaatcg atgcaaggag    120

cacaataaaa caaaagctac ttcggaacaa acagcattta aaaatccacg actcaagata    180

actgaaacct aaaataaaac ctgctcatgc acc atg gtt ttt caa act cgg tac     234
                                     Met Val Phe Gln Thr Arg Tyr
                                     1               5

cct tca tgg att att tta tgc tac atc tgg ctg ctc cgc ttt gca cac      282
Pro Ser Trp Ile Ile Leu Cys Tyr Ile Trp Leu Leu Arg Phe Ala His
        10                  15                  20

aca ggg gag gcg cag gct gcg aag gaa gta cta ctg ctg gat tct aaa      330
Thr Gly Glu Ala Gln Ala Ala Lys Glu Val Leu Leu Leu Asp Ser Lys
    25                  30                  35

gca caa caa aca gag ttg gag tgg att tcc tct cca ccc aat ggg tgg      378
Ala Gln Gln Thr Glu Leu Glu Trp Ile Ser Ser Pro Pro Asn Gly Trp
40                  45                  50                  55

gaa gaa att agt ggt ttg gat gag aac tat acc ccg ata cga aca tac      426
Glu Glu Ile Ser Gly Leu Asp Glu Asn Tyr Thr Pro Ile Arg Thr Tyr
                60                  65                  70

cag gtg tgc caa gtc atg gag ccc aac caa aac aac tgg ctg cgg act      474
Gln Val Cys Gln Val Met Glu Pro Asn Gln Asn Asn Trp Leu Arg Thr
            75                  80                  85

aac tgg att tcc aaa ggc aat gca caa agg att ttt gta gaa ttg aaa      522
Asn Trp Ile Ser Lys Gly Asn Ala Gln Arg Ile Phe Val Glu Leu Lys
        90                  95                  100

ttc acc ctg agg gat tgt aac agt ctt cct gga gta ctg gga act tgc      570
Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro Gly Val Leu Gly Thr Cys
    105                 110                 115

aag gaa aca ttt aat ttg tac tat tat gaa aca gac tat gac act ggc      618
Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu Thr Asp Tyr Asp Thr Gly
120                 125                 130                 135

agg aat ata aga gaa aac ctc tat gta aaa ata gac acc att gct gca      666
Arg Asn Ile Arg Glu Asn Leu Tyr Val Lys Ile Asp Thr Ile Ala Ala
                140                 145                 150

gat gaa agt ttt acc caa ggt gac ctt ggt gaa aga aag atg aag ctt      714
Asp Glu Ser Phe Thr Gln Gly Asp Leu Gly Glu Arg Lys Met Lys Leu
            155                 160                 165

aac act gag gtg aga gag att gga cct ttg tcc aaa aag gga ttc tat      762
Asn Thr Glu Val Arg Glu Ile Gly Pro Leu Ser Lys Lys Gly Phe Tyr
        170                 175                 180

ctt gcc ttt cag gat gta ggg gct tgc ata gct ttg gtt tct gtc aaa      810
Leu Ala Phe Gln Asp Val Gly Ala Cys Ile Ala Leu Val Ser Val Lys
    185                 190                 195

gtg tac tac aag aag tgc tgg tcc att att gag aac tta gct atc ttt      858
Val Tyr Tyr Lys Lys Cys Trp Ser Ile Ile Glu Asn Leu Ala Ile Phe
200                 205                 210                 215

cca gat aca gtg act ggt tca gaa ttt tcc tct tta gtc gag gtt cga      906
Pro Asp Thr Val Thr Gly Ser Glu Phe Ser Ser Leu Val Glu Val Arg
                220                 225                 230

ggg aca tgt gtc agc agt gca gag gaa gaa gcg gaa aac gcc ccc agg      954
Gly Thr Cys Val Ser Ser Ala Glu Glu Glu Ala Glu Asn Ala Pro Arg
            235                 240                 245

atg cac tgc agt gca gaa gga gaa tgg tta gtg ccc att gga aaa tgt     1002
Met His Cys Ser Ala Glu Gly Glu Trp Leu Val Pro Ile Gly Lys Cys
        250                 255                 260

atc tgc aaa gca ggc tac cag caa aaa gga gac act tgt gaa ccc tgt     1050
Ile Cys Lys Ala Gly Tyr Gln Gln Lys Gly Asp Thr Cys Glu Pro Cys
    265                 270                 275

ggc cgt ggg ttc tac aag tct tcc tct caa gat ctt cag tgc tct cgt     1098
Gly Arg Gly Phe Tyr Lys Ser Ser Ser Gln Asp Leu Gln Cys Ser Arg
280                 285                 290                 295

tgt cca act cac agt ttt tct gat aaa gaa ggc tcc tcc aga tgt gaa     1146
Cys Pro Thr His Ser Phe Ser Asp Lys Glu Gly Ser Ser Arg Cys Glu
                300                 305                 310

tgt gaa gat ggg tat tac agg gct cca tct gac cca cca tac gtt gca     1194
Cys Glu Asp Gly Tyr Tyr Arg Ala Pro Ser Asp Pro Pro Tyr Val Ala
            315                 320                 325

tgc aca agg cct cca tct gca cca cag aac ctc att ttc aac atc aac     1242
Cys Thr Arg Pro Pro Ser Ala Pro Gln Asn Leu Ile Phe Asn Ile Asn
        330                 335                 340

caa acc aca gta agt ttg gaa tgg agt cct cct gca gac aat ggg gga     1290
Gln Thr Thr Val Ser Leu Glu Trp Ser Pro Pro Ala Asp Asn Gly Gly
    345                 350                 355

aga aac gat gtg acc tac aga ata ttg tgt aag cgg tgc agt tgg gag     1338
Arg Asn Asp Val Thr Tyr Arg Ile Leu Cys Lys Arg Cys Ser Trp Glu
360                 365                 370                 375

cag ggc gaa tgt gtt ccc tgt ggg agt aac att gga tac atg ccc cag     1386
Gln Gly Glu Cys Val Pro Cys Gly Ser Asn Ile Gly Tyr Met Pro Gln
                380                 385                 390

cag act gga tta gag gat aac tat gtc act gtc atg gac ctg cta gcc     1434
Gln Thr Gly Leu Glu Asp Asn Tyr Val Thr Val Met Asp Leu Leu Ala
            395                 400                 405

cac gct aat tat act ttt gaa gtt gaa gct gta aat gga gtt tct gac     1482
His Ala Asn Tyr Thr Phe Glu Val Glu Ala Val Asn Gly Val Ser Asp
        410                 415                 420

tta agc cga tcc cag agg ctc ttt gct gct gtc agt atc acc act ggt     1530
Leu Ser Arg Ser Gln Arg Leu Phe Ala Ala Val Ser Ile Thr Thr Gly
    425                 430                 435

caa gca gct ccc tcg caa gtg agc gga gta atg aag gag aga gta ctg     1578
Gln Ala Ala Pro Ser Gln Val Ser Gly Val Met Lys Glu Arg Val Leu
440                 445                 450                 455

cag cgg agt gtc gag ctt tcc tgg cag gaa cca gag cat ccc aat gga     1626
Gln Arg Ser Val Glu Leu Ser Trp Gln Glu Pro Glu His Pro Asn Gly
                460                 465                 470

gtc atc aca gaa tat gaa atc aag tat tac gag aaa gat caa agg gaa     1674
Val Ile Thr Glu Tyr Glu Ile Lys Tyr Tyr Glu Lys Asp Gln Arg Glu
            475                 480                 485

cgg acc tac tca aca gta aaa acc aag tct act tca gcc tcc att aat     1722
Arg Thr Tyr Ser Thr Val Lys Thr Lys Ser Thr Ser Ala Ser Ile Asn
        490                 495                 500

aat ctg aaa cca gga aca gtg tat gtt ttc cag att cgg gct ttt act     1770
Asn Leu Lys Pro Gly Thr Val Tyr Val Phe Gln Ile Arg Ala Phe Thr
    505                 510                 515

gct gct ggt tat gga aat tac agt ccc aga ctt gat gtt gct aca cta     1818
Ala Ala Gly Tyr Gly Asn Tyr Ser Pro Arg Leu Asp Val Ala Thr Leu
520                 525                 530                 535

gag gaa gct aca ggt aaa atg ttt gaa gct aca gct gtc tcc agt gaa     1866
Glu Glu Ala Thr Gly Lys Met Phe Glu Ala Thr Ala Val Ser Ser Glu
                540                 545                 550

cag aat cct gtt att atc att gct gtg gtt gct gta gct ggg acc atc     1914
Gln Asn Pro Val Ile Ile Ile Ala Val Val Ala Val Ala Gly Thr Ile
            555                 560                 565

att ttg gtg ttc atg gtc ttt ggc ttc atc att ggg aga agg cac tgt     1962
Ile Leu Val Phe Met Val Phe Gly Phe Ile Ile Gly Arg Arg His Cys
        570                 575                 580

ggt tat agc aaa gct gac caa gaa ggc gat gaa gag ctt tac ttt cat     2010
Gly Tyr Ser Lys Ala Asp Gln Glu Gly Asp Glu Glu Leu Tyr Phe His
    585                 590                 595

ttt aaa ttt cca ggc acc aaa acc tac att gac cct gaa acc tat gag     2058
Phe Lys Phe Pro Gly Thr Lys Thr Tyr Ile Asp Pro Glu Thr Tyr Glu
600                 605                 610                 615

gac cca aat aga gct gtc cat caa ttc gcc aag gag cta gat gcc tcc     2106
Asp Pro Asn Arg Ala Val His Gln Phe Ala Lys Glu Leu Asp Ala Ser
                620                 625                 630

tgt att aaa att gag cgt gtg att ggt gca gga gaa ttc ggt gaa gtc     2154
Cys Ile Lys Ile Glu Arg Val Ile Gly Ala Gly Glu Phe Gly Glu Val
            635                 640                 645

tgc agt ggc cgt ttg aaa ctt cca ggg aaa aga gat gtt gca gta gcc     2202
Cys Ser Gly Arg Leu Lys Leu Pro Gly Lys Arg Asp Val Ala Val Ala
        650                 655                 660

ata aaa acc ctg aaa gtt ggt tac aca gaa aaa caa agg aga gac ttt     2250
Ile Lys Thr Leu Lys Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe
    665                 670                 675

ttg tgt gaa gca agc atc atg ggg cag ttt gac cac cca aat gtt gtc     2298
Leu Cys Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro Asn Val Val
680                 685                 690                 695

cat ttg gaa ggg gtt gtt aca aga ggg aaa cca gtc atg ata gta ata     2346
His Leu Glu Gly Val Val Thr Arg Gly Lys Pro Val Met Ile Val Ile
                700                 705                 710

gag ttc atg gaa aat gga gcc cta gat gca ttt ctc agg aaa cat gat     2394
Glu Phe Met Glu Asn Gly Ala Leu Asp Ala Phe Leu Arg Lys His Asp
            715                 720                 725

ggg caa ttt aca gtc att cag tta gta gga atg ctg aga gga att gct     2442
Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala
        730                 735                 740

gct gga atg aga tat ttg gct gat atg gga tat gtt cac agg gac ctt     2490
Ala Gly Met Arg Tyr Leu Ala Asp Met Gly Tyr Val His Arg Asp Leu
    745                 750                 755

gca gct cgc aat att ctt gtc aac agc aat ctc gtt tgt aaa gtg tca     2538
Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser
760                 765                 770                 775

gat ttt ggc ctg tcc cga gtt ata gag gat gat cca gaa gct gtc tat     2586
Asp Phe Gly Leu Ser Arg Val Ile Glu Asp Asp Pro Glu Ala Val Tyr
                780                 785                 790

aca act act ggt gga aaa att cca gta agg tgg aca gca ccc gaa gcc     2634
Thr Thr Thr Gly Gly Lys Ile Pro Val Arg Trp Thr Ala Pro Glu Ala
            795                 800                 805

atc cag tac cgg aaa ttc aca tca gcc agt gat gta tgg agc tat gga     2682
Ile Gln Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly
        810                 815                 820

ata gtc atg tgg gaa gtt atg tct tat gga gaa aga cct tat tgg gac     2730
Ile Val Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp
    825                 830                 835

atg tca aat caa gat gtt ata aaa gca ata gaa gaa ggt tat cgt tta     2778
Met Ser Asn Gln Asp Val Ile Lys Ala Ile Glu Glu Gly Tyr Arg Leu
840                 845                 850                 855

cca gca ccc atg gac tgc cca gct ggc ctt cac cag cta atg ttg gat     2826
Pro Ala Pro Met Asp Cys Pro Ala Gly Leu His Gln Leu Met Leu Asp
                860                 865                 870

tgt tgg caa aag gag cgt gct gaa agg cca aaa ttt gaa cag ata gtt     2874
Cys Trp Gln Lys Glu Arg Ala Glu Arg Pro Lys Phe Glu Gln Ile Val
            875                 880                 885

gga att cta gac aaa atg att cga aac cca aat agt ctg aaa act ccc     2922
Gly Ile Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Thr Pro
        890                 895                 900

ctg gga act tgt agt agg cca ata agc cct ctt ctg gat caa aac act     2970
Leu Gly Thr Cys Ser Arg Pro Ile Ser Pro Leu Leu Asp Gln Asn Thr
    905                 910                 915

cct gat ttc act acc ttt tgt tca gtt gga gaa tgg cta caa gct att     3018
Pro Asp Phe Thr Thr Phe Cys Ser Val Gly Glu Trp Leu Gln Ala Ile
920                 925                 930                 935

aag atg gaa aga tat aaa gat aat ttc acg gca gct ggc tac aat tcc     3066
Lys Met Glu Arg Tyr Lys Asp Asn Phe Thr Ala Ala Gly Tyr Asn Ser
                940                 945                 950

ctt gaa tca gta gcc agg atg act att gag gat gtg atg agt tta ggg     3114
Leu Glu Ser Val Ala Arg Met Thr Ile Glu Asp Val Met Ser Leu Gly
            955                 960                 965

atc aca ctg gtt ggt cat caa aag aaa atc atg agc agc att cag act     3162
Ile Thr Leu Val Gly His Gln Lys Lys Ile Met Ser Ser Ile Gln Thr
        970                 975                 980

atg aga gca caa atg cta cat tta cat gga act ggc att caa gtg tga     3210
Met Arg Ala Gln Met Leu His Leu His Gly Thr Gly Ile Gln Val
    985                 990                 995

tatgcatttc tcccttttaa gggagattac agactgcaag agaacagtac tggccttcag   3270

tatatgcata gaatgctgct agaagacaag tgatgtcctg ggtccttcca acagtgaaga   3330

gaagatttaa gaagcaccta tagacttgaa ctcctaagtg ccaccagaat atataaaaag   3390

ggaatttagg atccaccatc ggtggccagg aaaatagcag tgacaataaa caaagtacta   3450

cctgaaaaac atccaaacac cttgagctct ctaacctcct ttttgtctta tagacttttt   3510

aaaatgtaca taaagaattt aagaaagaat atatttgtca aataaaatca tgatcttatt   3570

gttaaaatta atgaaatatt ttccttaaat atgtgatttc agactattcc tttttaaaat   3630

catttgtgtt tattcttcat aaggactttg ttttagaaag ctgtttatag ctttggacct   3690

ttttagtgtt aaatctgtaa cattactaca ctgggtacct ttgaaagaat ctcaaatttc   3750

aaaagaaata gcatgattga agatacatct ctgttagaac attggtatcc tttttgtgcc   3810

attttattct gtttaatcag tgctgttttg atattgtttg ctaattggca ggtagtcaag   3870

aaaatgcaag ttgccaagag ctctgatatt ttttaaaaag aatttttttg taaagatcag   3930

acaacacact atcttttcaa tgaaaaaagc aataatgatc catacatact ataaggcact   3990

tttaacagat tgtttataga gtgattttac tagaaagaat ttaataaact cgaagtttag   4050

gtttatgagt atataaacaa atgaggcact tcatctgaag aatgttggtg aaggcaagtc   4110

tctgaaagca gaactatcca gtgttatcta aaaattaatc tgagcacatc aagatttttt   4170

cattctcgtg acattaggaa atttaggata aatagttgac atatatttta tatcctcttc   4230

tgttgaatgc agtccaaaca tgaaaggaaa taattgtttt atattataac tctgaagcat   4290

gataaagggg cagttcacaa ttttcaccat ttaaacacaa atttgctgca cagaatatca   4350

ccattgcagt tcaaaacaaa acaaaacaaa aagtcttttg tttgtgaaca ctgatgcaag   4410

aaacttgtta aatgaaagga ctctttaccc tagaaggaag aggtgaagga tctggcttgt   4470

ttttaaagct ttatttatta aaccatatta tttgattact gtgttagaat ttcataagca   4530

ataattaaat gtgtctttat agatattgca ggaatgtata catattgtga ttaatgcttt   4590

caaaacttat gaaaatcatg aactacccca gaattgaact gttgtacttc caaagagaat   4650

tgggctgttt ataatgattt taatagagaa agatcccagg gatcggtcat aattggtctt   4710

gtttgataat gtgggcatcc acaaacaaac aaacaaataa cagaaacaaa atctgtaaat   4770

gttcctttgt aaaacttgta aattttattt atactgtctt gttttgtaca cacatttctc   4830

tgtagtgggc tctgaataca ttgaaaatgc actatatttt tctattttac ttgcagagca   4890

tcacaaaaga acaggtattt tcagtgctac ataatgtgtt ttcccacatt taggaccaaa   4950

gacggctata gaaaaactca aatggattgc ttcccaaacc cctccccacc cttttttttt   5010

ggttttaaat cactgtacag tgttatttga tattttaatt tattttttga ttgactagaa   5070

aaatcatttt aatttcacta aaatgttttt tgtccctaag gaaaagtaat ctgtaaaaat   5130

aattttaatt agcataatac agtcacctag acacttccat ttgtaatctt tgtaatagac   5190

tgtaaatata tttttggaac tataaaaaaa aaaaaaaaa                          5229


<210>  10
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile
1               5                   10                  15


Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu
            20                  25                  30


Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile
        35                  40                  45


Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn
    50                  55                  60


Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn
65                  70                  75                  80


Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln
                85                  90                  95


Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu
            100                 105                 110


Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr
        115                 120                 125


Glu Thr Asp Tyr Asp Thr Gly Arg Asn Ile Arg Glu Asn Leu Tyr Val
    130                 135                 140


Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu
145                 150                 155                 160


Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro
                165                 170                 175


Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys
            180                 185                 190


Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile
        195                 200                 205


Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe
    210                 215                 220


Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu
225                 230                 235                 240


Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp
                245                 250                 255


Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys
            260                 265                 270


Gly Asp Thr Cys Glu Pro Cys Gly Arg Gly Phe Tyr Lys Ser Ser Ser
        275                 280                 285


Gln Asp Leu Gln Cys Ser Arg Cys Pro Thr His Ser Phe Ser Asp Lys
    290                 295                 300


Glu Gly Ser Ser Arg Cys Glu Cys Glu Asp Gly Tyr Tyr Arg Ala Pro
305                 310                 315                 320


Ser Asp Pro Pro Tyr Val Ala Cys Thr Arg Pro Pro Ser Ala Pro Gln
                325                 330                 335


Asn Leu Ile Phe Asn Ile Asn Gln Thr Thr Val Ser Leu Glu Trp Ser
            340                 345                 350


Pro Pro Ala Asp Asn Gly Gly Arg Asn Asp Val Thr Tyr Arg Ile Leu
        355                 360                 365


Cys Lys Arg Cys Ser Trp Glu Gln Gly Glu Cys Val Pro Cys Gly Ser
    370                 375                 380


Asn Ile Gly Tyr Met Pro Gln Gln Thr Gly Leu Glu Asp Asn Tyr Val
385                 390                 395                 400


Thr Val Met Asp Leu Leu Ala His Ala Asn Tyr Thr Phe Glu Val Glu
                405                 410                 415


Ala Val Asn Gly Val Ser Asp Leu Ser Arg Ser Gln Arg Leu Phe Ala
            420                 425                 430


Ala Val Ser Ile Thr Thr Gly Gln Ala Ala Pro Ser Gln Val Ser Gly
        435                 440                 445


Val Met Lys Glu Arg Val Leu Gln Arg Ser Val Glu Leu Ser Trp Gln
    450                 455                 460


Glu Pro Glu His Pro Asn Gly Val Ile Thr Glu Tyr Glu Ile Lys Tyr
465                 470                 475                 480


Tyr Glu Lys Asp Gln Arg Glu Arg Thr Tyr Ser Thr Val Lys Thr Lys
                485                 490                 495


Ser Thr Ser Ala Ser Ile Asn Asn Leu Lys Pro Gly Thr Val Tyr Val
            500                 505                 510


Phe Gln Ile Arg Ala Phe Thr Ala Ala Gly Tyr Gly Asn Tyr Ser Pro
        515                 520                 525


Arg Leu Asp Val Ala Thr Leu Glu Glu Ala Thr Gly Lys Met Phe Glu
    530                 535                 540


Ala Thr Ala Val Ser Ser Glu Gln Asn Pro Val Ile Ile Ile Ala Val
545                 550                 555                 560


Val Ala Val Ala Gly Thr Ile Ile Leu Val Phe Met Val Phe Gly Phe
                565                 570                 575


Ile Ile Gly Arg Arg His Cys Gly Tyr Ser Lys Ala Asp Gln Glu Gly
            580                 585                 590


Asp Glu Glu Leu Tyr Phe His Phe Lys Phe Pro Gly Thr Lys Thr Tyr
        595                 600                 605


Ile Asp Pro Glu Thr Tyr Glu Asp Pro Asn Arg Ala Val His Gln Phe
    610                 615                 620


Ala Lys Glu Leu Asp Ala Ser Cys Ile Lys Ile Glu Arg Val Ile Gly
625                 630                 635                 640


Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Gly
                645                 650                 655


Lys Arg Asp Val Ala Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr
            660                 665                 670


Glu Lys Gln Arg Arg Asp Phe Leu Cys Glu Ala Ser Ile Met Gly Gln
        675                 680                 685


Phe Asp His Pro Asn Val Val His Leu Glu Gly Val Val Thr Arg Gly
    690                 695                 700


Lys Pro Val Met Ile Val Ile Glu Phe Met Glu Asn Gly Ala Leu Asp
705                 710                 715                 720


Ala Phe Leu Arg Lys His Asp Gly Gln Phe Thr Val Ile Gln Leu Val
                725                 730                 735


Gly Met Leu Arg Gly Ile Ala Ala Gly Met Arg Tyr Leu Ala Asp Met
            740                 745                 750


Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser
        755                 760                 765


Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Ile Glu
    770                 775                 780


Asp Asp Pro Glu Ala Val Tyr Thr Thr Thr Gly Gly Lys Ile Pro Val
785                 790                 795                 800


Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala
                805                 810                 815


Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr
            820                 825                 830


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Lys Ala
        835                 840                 845


Ile Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Asp Cys Pro Ala Gly
    850                 855                 860


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu Arg Ala Glu Arg
865                 870                 875                 880


Pro Lys Phe Glu Gln Ile Val Gly Ile Leu Asp Lys Met Ile Arg Asn
                885                 890                 895


Pro Asn Ser Leu Lys Thr Pro Leu Gly Thr Cys Ser Arg Pro Ile Ser
            900                 905                 910


Pro Leu Leu Asp Gln Asn Thr Pro Asp Phe Thr Thr Phe Cys Ser Val
        915                 920                 925


Gly Glu Trp Leu Gln Ala Ile Lys Met Glu Arg Tyr Lys Asp Asn Phe
    930                 935                 940


Thr Ala Ala Gly Tyr Asn Ser Leu Glu Ser Val Ala Arg Met Thr Ile
945                 950                 955                 960


Glu Asp Val Met Ser Leu Gly Ile Thr Leu Val Gly His Gln Lys Lys
                965                 970                 975


Ile Met Ser Ser Ile Gln Thr Met Arg Ala Gln Met Leu His Leu His
            980                 985                 990


Gly Thr Gly Ile Gln Val
        995


<210>  11
<211>  4996
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (126)..(3143)

<400>  11
gcgccggggt gtgcgcccgg ccgggtgtgc ggagagcgag ggagcgcgct ccctcccgac     60

gcgcgggccg cagcggccaa gcccgagggt gcgtggcgcc cccgcccgcc cggcccggcc    120

cggcc atg gcc ccc gcc cgg ggc cgc ctg ccc cct gcg ctc tgg gtc gtc    170
      Met Ala Pro Ala Arg Gly Arg Leu Pro Pro Ala Leu Trp Val Val
      1               5                   10                  15

acg gcc gcg gcg gcg gcg gcc acc tgc gtg tcc gcg gcg cgc ggc gaa      218
Thr Ala Ala Ala Ala Ala Ala Thr Cys Val Ser Ala Ala Arg Gly Glu
                20                  25                  30

gtg aat ttg ctg gac acg tcg acc atc cac ggg gac tgg ggc tgg ctc      266
Val Asn Leu Leu Asp Thr Ser Thr Ile His Gly Asp Trp Gly Trp Leu
            35                  40                  45

acg tat ccg gct cat ggg tgg gac tcc atc aac gag gtg gac gag tcc      314
Thr Tyr Pro Ala His Gly Trp Asp Ser Ile Asn Glu Val Asp Glu Ser
        50                  55                  60

ttc cag ccc atc cac acg tac cag gtt tgc aac gtc atg agc ccc aac      362
Phe Gln Pro Ile His Thr Tyr Gln Val Cys Asn Val Met Ser Pro Asn
    65                  70                  75

cag aac aac tgg ctg cgc acg agc tgg gtc ccc cga gac ggc gcc cgg      410
Gln Asn Asn Trp Leu Arg Thr Ser Trp Val Pro Arg Asp Gly Ala Arg
80                  85                  90                  95

cgc gtc tat gct gag atc aag ttt acc ctg cgc gac tgc aac agc atg      458
Arg Val Tyr Ala Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Met
                100                 105                 110

cct ggt gtg ctg ggc acc tgc aag gag acc ttc aac ctc tac tac ctg      506
Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Leu
            115                 120                 125

gag tcg gac cgc gac ctg ggg gcc agc aca caa gaa agc cag ttc ctc      554
Glu Ser Asp Arg Asp Leu Gly Ala Ser Thr Gln Glu Ser Gln Phe Leu
        130                 135                 140

aaa atc gac acc att gcg gcc gac gag agc ttc aca ggt gcc gac ctt      602
Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gly Ala Asp Leu
    145                 150                 155

ggt gtg cgg cgt ctc aag ctc aac acg gag gtg cgc agt gtg ggt ccc      650
Gly Val Arg Arg Leu Lys Leu Asn Thr Glu Val Arg Ser Val Gly Pro
160                 165                 170                 175

ctc agc aag cgc ggc ttc tac ctg gcc ttc cag gac ata ggt gcc tgc      698
Leu Ser Lys Arg Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys
                180                 185                 190

ctg gcc atc ctc tct ctc cgc atc tac tat aag aag tgc cct gcc atg      746
Leu Ala Ile Leu Ser Leu Arg Ile Tyr Tyr Lys Lys Cys Pro Ala Met
            195                 200                 205

gtg cgc aat ctg gct gcc ttc tcg gag gca gtg acg ggg gcc gac tcg      794
Val Arg Asn Leu Ala Ala Phe Ser Glu Ala Val Thr Gly Ala Asp Ser
        210                 215                 220

tcc tca ctg gtg gag gtg agg ggc cag tgc gtg cgg cac tca gag gag      842
Ser Ser Leu Val Glu Val Arg Gly Gln Cys Val Arg His Ser Glu Glu
    225                 230                 235

cgg gac aca ccc aag atg tac tgc agc gcg gag ggc gag tgg ctc gtg      890
Arg Asp Thr Pro Lys Met Tyr Cys Ser Ala Glu Gly Glu Trp Leu Val
240                 245                 250                 255

ccc atc ggc aaa tgc gtg tgc agt gcc ggc tac gag gag cgg cgg gat      938
Pro Ile Gly Lys Cys Val Cys Ser Ala Gly Tyr Glu Glu Arg Arg Asp
                260                 265                 270

gcc tgt gtg gcc tgt gag ctg ggc ttc tac aag tca gcc cct ggg gac      986
Ala Cys Val Ala Cys Glu Leu Gly Phe Tyr Lys Ser Ala Pro Gly Asp
            275                 280                 285

cag ctg tgt gcc cgc tgc cct ccc cac agc cac tcc gca gct cca gcc     1034
Gln Leu Cys Ala Arg Cys Pro Pro His Ser His Ser Ala Ala Pro Ala
        290                 295                 300

gcc caa gcc tgc cac tgt gac ctc agc tac tac cgt gca gcc ctg gac     1082
Ala Gln Ala Cys His Cys Asp Leu Ser Tyr Tyr Arg Ala Ala Leu Asp
    305                 310                 315

ccg ccg tcc tca gcc tgc acc cgg cca ccc tcg gca cca gtg aac ctg     1130
Pro Pro Ser Ser Ala Cys Thr Arg Pro Pro Ser Ala Pro Val Asn Leu
320                 325                 330                 335

atc tcc agt gtg aat ggg aca tca gtg act ctg gag tgg gcc cct ccc     1178
Ile Ser Ser Val Asn Gly Thr Ser Val Thr Leu Glu Trp Ala Pro Pro
                340                 345                 350

ctg gac cca ggt ggc cgc agt gac atc acc tac aat gcc gtg tgc cgc     1226
Leu Asp Pro Gly Gly Arg Ser Asp Ile Thr Tyr Asn Ala Val Cys Arg
            355                 360                 365

cgc tgc ccc tgg gca ctg agc cgc tgc gag gca tgt ggg agc ggc acc     1274
Arg Cys Pro Trp Ala Leu Ser Arg Cys Glu Ala Cys Gly Ser Gly Thr
        370                 375                 380

cgc ttt gtg ccc cag cag aca agc ctg gtg cag gcc agc ctg ctg gtg     1322
Arg Phe Val Pro Gln Gln Thr Ser Leu Val Gln Ala Ser Leu Leu Val
    385                 390                 395

gcc aac ctg ctg gcc cac atg aac tac tcc ttc tgg atc gag gcc gtc     1370
Ala Asn Leu Leu Ala His Met Asn Tyr Ser Phe Trp Ile Glu Ala Val
400                 405                 410                 415

aat ggc gtg tcc gac ctg agc ccc gag ccc cgc cgg gcc gct gtg gtc     1418
Asn Gly Val Ser Asp Leu Ser Pro Glu Pro Arg Arg Ala Ala Val Val
                420                 425                 430

aac atc acc acg aac cag gca gcc ccg tcc cag gtg gtg gtg atc cgt     1466
Asn Ile Thr Thr Asn Gln Ala Ala Pro Ser Gln Val Val Val Ile Arg
            435                 440                 445

caa gag cgg gcg ggg cag acc agc gtc tcg ctg ctg tgg cag gag ccc     1514
Gln Glu Arg Ala Gly Gln Thr Ser Val Ser Leu Leu Trp Gln Glu Pro
        450                 455                 460

gag cag ccg aac ggc atc atc ctg gag tat gag atc aag tac tac gag     1562
Glu Gln Pro Asn Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Tyr Glu
    465                 470                 475

aag gac aag gag atg cag agc tac tcc acc ctc aag gcc gtc acc acc     1610
Lys Asp Lys Glu Met Gln Ser Tyr Ser Thr Leu Lys Ala Val Thr Thr
480                 485                 490                 495

aga gcc acc gtc tcc ggc ctc aag ccg ggc acc cgc tac gtg ttc cag     1658
Arg Ala Thr Val Ser Gly Leu Lys Pro Gly Thr Arg Tyr Val Phe Gln
                500                 505                 510

gtc cga gcc cgc acc tca gca ggc tgt ggc cgc ttc agc cag gcc atg     1706
Val Arg Ala Arg Thr Ser Ala Gly Cys Gly Arg Phe Ser Gln Ala Met
            515                 520                 525

gag gtg gag acc ggg aaa ccc cgg ccc cgc tat gac acc agg acc att     1754
Glu Val Glu Thr Gly Lys Pro Arg Pro Arg Tyr Asp Thr Arg Thr Ile
        530                 535                 540

gtc tgg atc tgc ctg acg ctc atc acg ggc ctg gtg gtg ctt ctg ctc     1802
Val Trp Ile Cys Leu Thr Leu Ile Thr Gly Leu Val Val Leu Leu Leu
    545                 550                 555

ctg ctc atc tgc aag aag agg cac tgt ggc tac agc aag gcc ttc cag     1850
Leu Leu Ile Cys Lys Lys Arg His Cys Gly Tyr Ser Lys Ala Phe Gln
560                 565                 570                 575

gac tcg gac gag gag aag atg cac tat cag aat gga cag gca ccc cca     1898
Asp Ser Asp Glu Glu Lys Met His Tyr Gln Asn Gly Gln Ala Pro Pro
                580                 585                 590

cct gtc ttc ctg cct ctg cat cac ccc ccg gga aag ctc cca gag ccc     1946
Pro Val Phe Leu Pro Leu His His Pro Pro Gly Lys Leu Pro Glu Pro
            595                 600                 605

cag ttc tat gcg gaa ccc cac acc tac gag gag cca ggc cgg gcg ggc     1994
Gln Phe Tyr Ala Glu Pro His Thr Tyr Glu Glu Pro Gly Arg Ala Gly
        610                 615                 620

cgc agt ttc act cgg gag atc gag gcc tct agg atc cac atc gag aaa     2042
Arg Ser Phe Thr Arg Glu Ile Glu Ala Ser Arg Ile His Ile Glu Lys
    625                 630                 635

atc atc ggc tct gga gac tcc ggg gaa gtc tgc tac ggg agg ctg cgg     2090
Ile Ile Gly Ser Gly Asp Ser Gly Glu Val Cys Tyr Gly Arg Leu Arg
640                 645                 650                 655

gtg cca ggg cag cgg gat gtg ccc gtg gcc atc aag gcc ctc aaa gcc     2138
Val Pro Gly Gln Arg Asp Val Pro Val Ala Ile Lys Ala Leu Lys Ala
                660                 665                 670

ggc tac acg gag aga cag agg cgg gac ttc ctg agc gag gcg tcc atc     2186
Gly Tyr Thr Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile
            675                 680                 685

atg ggg caa ttc gac cat ccc aac atc atc cgc ctc gag ggt gtc gtc     2234
Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val
        690                 695                 700

acc cgt ggc cgc ctg gca atg att gtg act gag tac atg gag aac ggc     2282
Thr Arg Gly Arg Leu Ala Met Ile Val Thr Glu Tyr Met Glu Asn Gly
    705                 710                 715

tct ctg gac acc ttc ctg agg acc cac gac ggg cag ttc acc atc atg     2330
Ser Leu Asp Thr Phe Leu Arg Thr His Asp Gly Gln Phe Thr Ile Met
720                 725                 730                 735

cag ctg gtg ggc atg ctg aga gga gtg ggt gcc ggc atg cgc tac ctc     2378
Gln Leu Val Gly Met Leu Arg Gly Val Gly Ala Gly Met Arg Tyr Leu
                740                 745                 750

tca gac ctg ggc tat gtc cac cga gac ctg gcc gcc cgc aac gtc ctg     2426
Ser Asp Leu Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Val Leu
            755                 760                 765

gtt gac agc aac ctg gtc tgc aag gtg tct gac ttc ggg ctc tca cgg     2474
Val Asp Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg
        770                 775                 780

gtg ctg gag gac gac ccg gat gct gcc tac acc acc acg ggc ggg aag     2522
Val Leu Glu Asp Asp Pro Asp Ala Ala Tyr Thr Thr Thr Gly Gly Lys
    785                 790                 795

atc ccc atc cgc tgg acg gcc cca gag gcc atc gcc ttc cgc acc ttc     2570
Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Thr Phe
800                 805                 810                 815

tcc tcg gcc agc gac gtg tgg agc ttc ggc gtg gtc atg tgg gag gtg     2618
Ser Ser Ala Ser Asp Val Trp Ser Phe Gly Val Val Met Trp Glu Val
                820                 825                 830

ctg gcc tat ggg gag cgg ccc tac tgg aac atg acc aac cgg gat gtc     2666
Leu Ala Tyr Gly Glu Arg Pro Tyr Trp Asn Met Thr Asn Arg Asp Val
            835                 840                 845

atc agc tct gtg gag gag ggg tac cgc ctg ccc gca ccc atg ggc tgc     2714
Ile Ser Ser Val Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Gly Cys
        850                 855                 860

ccc cac gcc ctg cac cag ctc atg ctc gac tgt tgg cac aag gac cgg     2762
Pro His Ala Leu His Gln Leu Met Leu Asp Cys Trp His Lys Asp Arg
    865                 870                 875

gcg cag cgg cct cgc ttc tcc cag att gtc agt gtc ctc gat gcg ctc     2810
Ala Gln Arg Pro Arg Phe Ser Gln Ile Val Ser Val Leu Asp Ala Leu
880                 885                 890                 895

atc cgc agc cct gag agt ctc agg gcc acc gcc aca gtc agc agg tgc     2858
Ile Arg Ser Pro Glu Ser Leu Arg Ala Thr Ala Thr Val Ser Arg Cys
                900                 905                 910

cca ccc cct gcc ttc gtc cgg agc tgc ttt gac ctc cga ggg ggc agc     2906
Pro Pro Pro Ala Phe Val Arg Ser Cys Phe Asp Leu Arg Gly Gly Ser
            915                 920                 925

ggt ggc ggt ggg ggc ctc acc gtg ggg gac tgg ctg gac tcc atc cgc     2954
Gly Gly Gly Gly Gly Leu Thr Val Gly Asp Trp Leu Asp Ser Ile Arg
        930                 935                 940

atg ggc cgg tac cga gac cac ttc gct gcg ggc gga tac tcc tct ctg     3002
Met Gly Arg Tyr Arg Asp His Phe Ala Ala Gly Gly Tyr Ser Ser Leu
    945                 950                 955

ggc atg gtg cta cgc atg aac gcc cag gac gtg cgc gcc ctg ggc atc     3050
Gly Met Val Leu Arg Met Asn Ala Gln Asp Val Arg Ala Leu Gly Ile
960                 965                 970                 975

acc ctc atg ggc cac cag aag aag atc ctg ggc agc att cag acc atg     3098
Thr Leu Met Gly His Gln Lys Lys Ile Leu Gly Ser Ile Gln Thr Met
                980                 985                 990

cgg gcc cag ctg acc agc acc cag ggg  ccc cgc cgg cac ctc  tga       3143
Arg Ala Gln Leu Thr Ser Thr Gln Gly  Pro Arg Arg His Leu
            995                 1000                 1005

tgtacagcca gcagggccca ggcagccacc aagcccaccc caggtcatgc cagcggcaga   3203

ggacgtgagg ggctggcagc aggcagggcg gccccaggcc tctgccctcc tctcaggtgc   3263

tggaggagct gaaggcttcg ccacaggacc tggagttatc aggggtcagg cgcctgggaa   3323

ggggcctttg gtggccaccc tggtgaggac acctgtcccc cagggcaggc accttctctt   3383

ttccagagcc tggggcctcc acgtcacaga gtccaacagg gacatcactc gcctgcctct   3443

gtgtgcgtgc atgtgtgtgt gtggtggggg gtgttctcac aaggtcatgg gatctcatgt   3503

gaacagtgtg tgatcaagtg tgtccacccc ttcgggtctc agcatggacg tgtgcatgtt   3563

atgagcgtgt gcttatccgt taaggctgga ggcacatgtg ggtgatggtg gatgatgtgt   3623

catgaatgag gaggtgtgtg agcagggaac tcagtgtgac accgccaggt ccagcaccca   3683

tgggggcggg ggagaggctc acccctacgt ccccccacac ctggaggctg gagccagggg   3743

ccacttctga actgcaccag caccaggccc accctcgtct ctgcctgggt gagcccaccc   3803

cggctgtatc tcaggtctgg gtcctccctc tagccgagga ggccacctgc agcctccacc   3863

cggctctcac cgctgcttca acaggaaaac agggttcccg gtcagtccgg ctggccgcct   3923

tcatggaggc atcatggcag agcacatgag atgtcctcag ctgggcttgg ctgcctggcc   3983

agggccgggg gctcagcagc ctcctctagc ctctgatgcc ttccctccac ggcccaggtc   4043

tcctcactca aagtcccttc gccaaccttt caatgcccag ccctgacacc tgccctttgt   4103

cccccaggcc taggatcagg gaccagagga tcctatcttc tcagcaccca gcccacccct   4163

tcctgtagca tatggggaga ctaaggcctg gagagagggg tgatgccccg tcccaggttg   4223

cactgcaacc aagtgtcaga gtcggggctc cggcctcctg ccaaggctct tgtccccata   4283

caccatccca caagggcgct gggggtggaa gtgccctgga agcccctccc ctctcacact   4343

gacctccccc cttacggccc accagggtat gtaaatatct cttttctacc atgtcagaat   4403

attttttcct cactcctgac aatgcaaaaa tggtcttcaa agcacataaa aagcacccag   4463

ggtgagaaag ccccatcccg ggggccgttg gcaggcaggg aagcaggaac cccaccgtgt   4523

gccccctgcc agccccagag ggagtggcga gcccagctgc ccagccctgc cccccctccc   4583

catagccagc acagctatcc cgcggggaca ccagcactga gccccctctc cctcctgcaa   4643

taattcgggg agtctcagcc ccatccaggt gccgcggcca gctctctaca cctctatata   4703

ttatattact atatagccga gctgttcttc cttcctatgg aagtcggaaa catggtcaga   4763

acacgatctg ggggggggat cctgtcttcc tccccacccc accccactct tacccaattt   4823

ctgggctctg gatcctcaca gtcatggagg caccgtgggc ctggcacttg caaaagtgtg   4883

gcccctcact ctagtgtgtg gtccctctca gggtcctggg gatctgcctc tctgtggtct   4943

ccatcctgac tcttgaactt acccacaata agaataaatt ctgcctcatc ttt          4996


<210>  12
<211>  1005
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Pro Ala Arg Gly Arg Leu Pro Pro Ala Leu Trp Val Val Thr
1               5                   10                  15


Ala Ala Ala Ala Ala Ala Thr Cys Val Ser Ala Ala Arg Gly Glu Val
            20                  25                  30


Asn Leu Leu Asp Thr Ser Thr Ile His Gly Asp Trp Gly Trp Leu Thr
        35                  40                  45


Tyr Pro Ala His Gly Trp Asp Ser Ile Asn Glu Val Asp Glu Ser Phe
    50                  55                  60


Gln Pro Ile His Thr Tyr Gln Val Cys Asn Val Met Ser Pro Asn Gln
65                  70                  75                  80


Asn Asn Trp Leu Arg Thr Ser Trp Val Pro Arg Asp Gly Ala Arg Arg
                85                  90                  95


Val Tyr Ala Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Met Pro
            100                 105                 110


Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Leu Glu
        115                 120                 125


Ser Asp Arg Asp Leu Gly Ala Ser Thr Gln Glu Ser Gln Phe Leu Lys
    130                 135                 140


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gly Ala Asp Leu Gly
145                 150                 155                 160


Val Arg Arg Leu Lys Leu Asn Thr Glu Val Arg Ser Val Gly Pro Leu
                165                 170                 175


Ser Lys Arg Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Leu
            180                 185                 190


Ala Ile Leu Ser Leu Arg Ile Tyr Tyr Lys Lys Cys Pro Ala Met Val
        195                 200                 205


Arg Asn Leu Ala Ala Phe Ser Glu Ala Val Thr Gly Ala Asp Ser Ser
    210                 215                 220


Ser Leu Val Glu Val Arg Gly Gln Cys Val Arg His Ser Glu Glu Arg
225                 230                 235                 240


Asp Thr Pro Lys Met Tyr Cys Ser Ala Glu Gly Glu Trp Leu Val Pro
                245                 250                 255


Ile Gly Lys Cys Val Cys Ser Ala Gly Tyr Glu Glu Arg Arg Asp Ala
            260                 265                 270


Cys Val Ala Cys Glu Leu Gly Phe Tyr Lys Ser Ala Pro Gly Asp Gln
        275                 280                 285


Leu Cys Ala Arg Cys Pro Pro His Ser His Ser Ala Ala Pro Ala Ala
    290                 295                 300


Gln Ala Cys His Cys Asp Leu Ser Tyr Tyr Arg Ala Ala Leu Asp Pro
305                 310                 315                 320


Pro Ser Ser Ala Cys Thr Arg Pro Pro Ser Ala Pro Val Asn Leu Ile
                325                 330                 335


Ser Ser Val Asn Gly Thr Ser Val Thr Leu Glu Trp Ala Pro Pro Leu
            340                 345                 350


Asp Pro Gly Gly Arg Ser Asp Ile Thr Tyr Asn Ala Val Cys Arg Arg
        355                 360                 365


Cys Pro Trp Ala Leu Ser Arg Cys Glu Ala Cys Gly Ser Gly Thr Arg
    370                 375                 380


Phe Val Pro Gln Gln Thr Ser Leu Val Gln Ala Ser Leu Leu Val Ala
385                 390                 395                 400


Asn Leu Leu Ala His Met Asn Tyr Ser Phe Trp Ile Glu Ala Val Asn
                405                 410                 415


Gly Val Ser Asp Leu Ser Pro Glu Pro Arg Arg Ala Ala Val Val Asn
            420                 425                 430


Ile Thr Thr Asn Gln Ala Ala Pro Ser Gln Val Val Val Ile Arg Gln
        435                 440                 445


Glu Arg Ala Gly Gln Thr Ser Val Ser Leu Leu Trp Gln Glu Pro Glu
    450                 455                 460


Gln Pro Asn Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Tyr Glu Lys
465                 470                 475                 480


Asp Lys Glu Met Gln Ser Tyr Ser Thr Leu Lys Ala Val Thr Thr Arg
                485                 490                 495


Ala Thr Val Ser Gly Leu Lys Pro Gly Thr Arg Tyr Val Phe Gln Val
            500                 505                 510


Arg Ala Arg Thr Ser Ala Gly Cys Gly Arg Phe Ser Gln Ala Met Glu
        515                 520                 525


Val Glu Thr Gly Lys Pro Arg Pro Arg Tyr Asp Thr Arg Thr Ile Val
    530                 535                 540


Trp Ile Cys Leu Thr Leu Ile Thr Gly Leu Val Val Leu Leu Leu Leu
545                 550                 555                 560


Leu Ile Cys Lys Lys Arg His Cys Gly Tyr Ser Lys Ala Phe Gln Asp
                565                 570                 575


Ser Asp Glu Glu Lys Met His Tyr Gln Asn Gly Gln Ala Pro Pro Pro
            580                 585                 590


Val Phe Leu Pro Leu His His Pro Pro Gly Lys Leu Pro Glu Pro Gln
        595                 600                 605


Phe Tyr Ala Glu Pro His Thr Tyr Glu Glu Pro Gly Arg Ala Gly Arg
    610                 615                 620


Ser Phe Thr Arg Glu Ile Glu Ala Ser Arg Ile His Ile Glu Lys Ile
625                 630                 635                 640


Ile Gly Ser Gly Asp Ser Gly Glu Val Cys Tyr Gly Arg Leu Arg Val
                645                 650                 655


Pro Gly Gln Arg Asp Val Pro Val Ala Ile Lys Ala Leu Lys Ala Gly
            660                 665                 670


Tyr Thr Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met
        675                 680                 685


Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr
    690                 695                 700


Arg Gly Arg Leu Ala Met Ile Val Thr Glu Tyr Met Glu Asn Gly Ser
705                 710                 715                 720


Leu Asp Thr Phe Leu Arg Thr His Asp Gly Gln Phe Thr Ile Met Gln
                725                 730                 735


Leu Val Gly Met Leu Arg Gly Val Gly Ala Gly Met Arg Tyr Leu Ser
            740                 745                 750


Asp Leu Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val
        755                 760                 765


Asp Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val
    770                 775                 780


Leu Glu Asp Asp Pro Asp Ala Ala Tyr Thr Thr Thr Gly Gly Lys Ile
785                 790                 795                 800


Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Thr Phe Ser
                805                 810                 815


Ser Ala Ser Asp Val Trp Ser Phe Gly Val Val Met Trp Glu Val Leu
            820                 825                 830


Ala Tyr Gly Glu Arg Pro Tyr Trp Asn Met Thr Asn Arg Asp Val Ile
        835                 840                 845


Ser Ser Val Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Gly Cys Pro
    850                 855                 860


His Ala Leu His Gln Leu Met Leu Asp Cys Trp His Lys Asp Arg Ala
865                 870                 875                 880


Gln Arg Pro Arg Phe Ser Gln Ile Val Ser Val Leu Asp Ala Leu Ile
                885                 890                 895


Arg Ser Pro Glu Ser Leu Arg Ala Thr Ala Thr Val Ser Arg Cys Pro
            900                 905                 910


Pro Pro Ala Phe Val Arg Ser Cys Phe Asp Leu Arg Gly Gly Ser Gly
        915                 920                 925


Gly Gly Gly Gly Leu Thr Val Gly Asp Trp Leu Asp Ser Ile Arg Met
    930                 935                 940


Gly Arg Tyr Arg Asp His Phe Ala Ala Gly Gly Tyr Ser Ser Leu Gly
945                 950                 955                 960


Met Val Leu Arg Met Asn Ala Gln Asp Val Arg Ala Leu Gly Ile Thr
                965                 970                 975


Leu Met Gly His Gln Lys Lys Ile Leu Gly Ser Ile Gln Thr Met Arg
            980                 985                 990


Ala Gln Leu Thr Ser Thr Gln Gly  Pro Arg Arg His Leu
        995                 1000                 1005


<210>  13
<211>  4536
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (221)..(3175)

<400>  13
gaattccaca tgcacaccca cacccacgcg cgcccgcacc gccccacgcg cacacactcc     60

tgcccacgcc cacgcagcgc tccgggaagt ccggtccggg cgagagcgcg aaaggatacc    120

gagaagccac ccgcggagag cgcagcggcg ccctgggacg cggcgctctc ccggcgctgc    180

tgcctcggct tggtctcggc ctgcgggccg tcggccggcg atg gcc ctg gat tat      235
                                            Met Ala Leu Asp Tyr
                                            1               5

cta cta ctg ctc ctc ctg gca tcc gca gtg gct gcg atg gaa gaa acg      283
Leu Leu Leu Leu Leu Leu Ala Ser Ala Val Ala Ala Met Glu Glu Thr
                10                  15                  20

tta atg gac acc aga acg gct act gca gag ctg ggc tgg acg gcc aat      331
Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu Gly Trp Thr Ala Asn
            25                  30                  35

cct gcg tcc ggg tgg gaa gaa gtc agt ggc tac gat gaa aac ctg aac      379
Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr Asp Glu Asn Leu Asn
        40                  45                  50

acc atc cgc acc tac cag gtg tgc aat gtc ttc gag ccc aac cag aac      427
Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe Glu Pro Asn Gln Asn
    55                  60                  65

aat tgg ctg ctc acc acc ttc atc aac cgg cgg ggg gcc cat cgc atc      475
Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg Gly Ala His Arg Ile
70                  75                  80                  85

tac aca gag atg cgc ttc act gtg aga gac tgc agc agc ctc cct aat      523
Tyr Thr Glu Met Arg Phe Thr Val Arg Asp Cys Ser Ser Leu Pro Asn
                90                  95                  100

gtc cca gga tcc tgc aag gag acc ttc aac ttg tat tac tat gag act      571
Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu Thr
            105                 110                 115

gac tct gtc att gcc acc aag aag tca gcc ttc tgg tct gag gcc ccc      619
Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe Trp Ser Glu Ala Pro
        120                 125                 130

tac ctc aaa gta gac acc att gct gca gat gag agc ttc tcc cag gtg      667
Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu Ser Phe Ser Gln Val
    135                 140                 145

gac ttt ggg gga agg ctg atg aag gta aac aca gaa gtc agg agc ttt      715
Asp Phe Gly Gly Arg Leu Met Lys Val Asn Thr Glu Val Arg Ser Phe
150                 155                 160                 165

ggg cct ctt act cgg aat ggt ttt tac ctc gct ttt cag gat tat gga      763
Gly Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala Phe Gln Asp Tyr Gly
                170                 175                 180

gcc tgt atg tct ctt ctt tct gtc cgt gtc ttc ttc aaa aag tgt ccc      811
Ala Cys Met Ser Leu Leu Ser Val Arg Val Phe Phe Lys Lys Cys Pro
            185                 190                 195

agc att gtg caa aat ttt gca gtg ttt cca gag act atg aca ggg gca      859
Ser Ile Val Gln Asn Phe Ala Val Phe Pro Glu Thr Met Thr Gly Ala
        200                 205                 210

gag agc aca tct ctg gtg att gct cgg ggc aca tgc atc ccc aac gca      907
Glu Ser Thr Ser Leu Val Ile Ala Arg Gly Thr Cys Ile Pro Asn Ala
    215                 220                 225

gag gaa gtg gac gtg ccc atc aaa ctc tac tgc aac ggg gat ggg gaa      955
Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys Asn Gly Asp Gly Glu
230                 235                 240                 245

tgg atg gtg cct att ggg cga tgc acc tgc aag cct ggc tat gag cct     1003
Trp Met Val Pro Ile Gly Arg Cys Thr Cys Lys Pro Gly Tyr Glu Pro
                250                 255                 260

gag aac agc gtg gca tgc aag gct tgc cct gca ggg aca ttc aag gcc     1051
Glu Asn Ser Val Ala Cys Lys Ala Cys Pro Ala Gly Thr Phe Lys Ala
            265                 270                 275

agc cag gaa gct gaa ggc tgc tcc cac tgc ccc tcc aac agc cgc tcc     1099
Ser Gln Glu Ala Glu Gly Cys Ser His Cys Pro Ser Asn Ser Arg Ser
        280                 285                 290

cct gca gag gcg tct ccc atc tgc acc tgt cgg acc ggt tat tac cga     1147
Pro Ala Glu Ala Ser Pro Ile Cys Thr Cys Arg Thr Gly Tyr Tyr Arg
    295                 300                 305

gcg gac ttt gac cct cca gaa gtg gca tgc act agc gtc cca tca ggt     1195
Ala Asp Phe Asp Pro Pro Glu Val Ala Cys Thr Ser Val Pro Ser Gly
310                 315                 320                 325

ccc cgc aat gtt atc tcc atc gtc aat gag acg tcc atc att ctg gag     1243
Pro Arg Asn Val Ile Ser Ile Val Asn Glu Thr Ser Ile Ile Leu Glu
                330                 335                 340

tgg cac cct cca agg gag aca ggt ggg cgg gat gat gtg acc tac aac     1291
Trp His Pro Pro Arg Glu Thr Gly Gly Arg Asp Asp Val Thr Tyr Asn
            345                 350                 355

atc atc tgc aaa aag tgc cgg gca gac cgc cgg agc tgc tcc cgc tgt     1339
Ile Ile Cys Lys Lys Cys Arg Ala Asp Arg Arg Ser Cys Ser Arg Cys
        360                 365                 370

gac gac aat gtg gag ttt gtg ccc agg cag ctg ggc ctg acg gag tgc     1387
Asp Asp Asn Val Glu Phe Val Pro Arg Gln Leu Gly Leu Thr Glu Cys
    375                 380                 385

cgc gtc tcc atc agc agc ctg tgg gcc cac acc ccc tac acc ttt gac     1435
Arg Val Ser Ile Ser Ser Leu Trp Ala His Thr Pro Tyr Thr Phe Asp
390                 395                 400                 405

atc cag gcc atc aat gga gtc tcc agc aag agt ccc ttc ccc cca cag     1483
Ile Gln Ala Ile Asn Gly Val Ser Ser Lys Ser Pro Phe Pro Pro Gln
                410                 415                 420

cac gtc tct gtc aac atc acc aca aac caa gcc gcc ccc tcc acc gtt     1531
His Val Ser Val Asn Ile Thr Thr Asn Gln Ala Ala Pro Ser Thr Val
            425                 430                 435

ccc atc atg cac caa gtc agt gcc act atg agg agc atc acc ttg tca     1579
Pro Ile Met His Gln Val Ser Ala Thr Met Arg Ser Ile Thr Leu Ser
        440                 445                 450

tgg cca cag ccg gag cag ccc aat ggc atc atc ctg gac tat gag atc     1627
Trp Pro Gln Pro Glu Gln Pro Asn Gly Ile Ile Leu Asp Tyr Glu Ile
    455                 460                 465

cgg tac tat gag aag gaa cac aat gag ttc aac tcc tcc atg gcc agg     1675
Arg Tyr Tyr Glu Lys Glu His Asn Glu Phe Asn Ser Ser Met Ala Arg
470                 475                 480                 485

agt cag acc aac aca gca agg att gat ggg ctg cgg cct ggc atg gta     1723
Ser Gln Thr Asn Thr Ala Arg Ile Asp Gly Leu Arg Pro Gly Met Val
                490                 495                 500

tat gtg gta cag gtg cgt gcc cgc act gtt gct ggc tac ggc aag ttc     1771
Tyr Val Val Gln Val Arg Ala Arg Thr Val Ala Gly Tyr Gly Lys Phe
            505                 510                 515

agt ggc aag atg tgc ttc cag act ctg act gac gat gat tac aag tca     1819
Ser Gly Lys Met Cys Phe Gln Thr Leu Thr Asp Asp Asp Tyr Lys Ser
        520                 525                 530

gag ctg agg gag cag ctg ccc ctg att gct ggc tcg gca gcg gcc ggg     1867
Glu Leu Arg Glu Gln Leu Pro Leu Ile Ala Gly Ser Ala Ala Ala Gly
    535                 540                 545

gtc gtg ttc gtt gtg tcc ttg gtg gcc atc tct atc gtc tgt agc agg     1915
Val Val Phe Val Val Ser Leu Val Ala Ile Ser Ile Val Cys Ser Arg
550                 555                 560                 565

aaa cgg gct tat agc aaa gag gct gtg tac agc gat aag ctc cag cat     1963
Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser Asp Lys Leu Gln His
                570                 575                 580

tac agc aca ggc cga ggc tcc cca ggg atg aag atc tac att gac ccc     2011
Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys Ile Tyr Ile Asp Pro
            585                 590                 595

ttc act tac gag gat ccc aac gaa gct gtc cgg gag ttt gcc aag gag     2059
Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys Glu
        600                 605                 610

att gat gta tct ttt gtg aaa att gaa gag gtc atc gga gca ggg gag     2107
Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val Ile Gly Ala Gly Glu
    615                 620                 625

ttt gga gaa gtg tac aag ggg cgt ttg aaa ctg cca ggc aag agg gaa     2155
Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu Pro Gly Lys Arg Glu
630                 635                 640                 645

atc tac gtg gcc atc aag acc ctg aag gca ggg tac tcg gag aag cag     2203
Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Ser Glu Lys Gln
                650                 655                 660

cgt cgg gac ttt ctg agt gag gcg agc atc atg ggc cag ttc gac cat     2251
Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Asp His
            665                 670                 675

cct aac atc att cgc ctg gag ggt gtg gtc acc aag agt cgg cct gtc     2299
Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Ser Arg Pro Val
        680                 685                 690

atg atc atc aca gag ttc atg gag aat ggt gca ttg gat tct ttc ctc     2347
Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ser Phe Leu
    695                 700                 705

agg caa aat gac ggg cag ttc acc gtg atc cag ctt gtg ggt atg ctc     2395
Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu
710                 715                 720                 725

agg ggc atc gct gct ggc atg aag tac ctg gct gag atg aat tat gtg     2443
Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Glu Met Asn Tyr Val
                730                 735                 740

cat cgg gac ctg gct gct agg aac att ctg gtc aac agt aac ctg gtg     2491
His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val
            745                 750                 755

tgc aag gtg tcc gac ttt ggc ctc tcc cgc tac ctc cag gat gac acc     2539
Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr Leu Gln Asp Asp Thr
        760                 765                 770

tca gat ccc acc tac acc agc tcc ttg gga ggg aag atc cct gtg aga     2587
Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile Pro Val Arg
    775                 780                 785

tgg aca gct cca gag gcc atc gcc tac cgc aag ttc act tca gcc agc     2635
Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr Ser Ala Ser
790                 795                 800                 805

gac gtt tgg agc tat ggg atc gtc atg tgg gaa gtc atg tca ttt gga     2683
Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Phe Gly
                810                 815                 820

gag aga ccc tat tgg gat atg tcc aac caa gat gtc atc aat gcc atc     2731
Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Asn Ala Ile
            825                 830                 835

gag cag gac tac cgg ctg ccc cca ccc atg gac tgt cca gct gct cta     2779
Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro Ala Ala Leu
        840                 845                 850

cac cag ctc atg ctg gac tgt tgg cag aag gac cgg aac agc cgg ccc     2827
His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Ser Arg Pro
    855                 860                 865

cgg ttt gcg gag att gtc aac acc cta gat aag atg atc cgg aac ccg     2875
Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys Met Ile Arg Asn Pro
870                 875                 880                 885

gca agt ctc aag act gtg gca acc atc acc gcc gtg cct tcc cag ccc     2923
Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala Val Pro Ser Gln Pro
                890                 895                 900

ctg ctc gac cgc tcc atc cca gac ttc acg gcc ttt acc acc gtg gat     2971
Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala Phe Thr Thr Val Asp
            905                 910                 915

gac tgg ctc agc gcc atc aaa atg gtc cag tac agg gac agc ttc ctc     3019
Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr Arg Asp Ser Phe Leu
        920                 925                 930

act gct ggc ttc acc tcc ctc cag ctg gtc acc cag atg aca tca gaa     3067
Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr Gln Met Thr Ser Glu
    935                 940                 945

gac ctc ctg aga ata ggc atc acc ttg gca ggc cat cag aag aag atc     3115
Asp Leu Leu Arg Ile Gly Ile Thr Leu Ala Gly His Gln Lys Lys Ile
950                 955                 960                 965

ctg aac agc att cat tct atg agg gtc cag ata agt cag tca cca acg     3163
Leu Asn Ser Ile His Ser Met Arg Val Gln Ile Ser Gln Ser Pro Thr
                970                 975                 980

gca atg gca tga gaactcttgt ttcttgggga aggagaggag ggaaaaggac         3215
Ala Met Ala


cagggtcaag ggggaccaga ggttgaccac tgtggaatgt actggagaga ctggcttctc   3275

agctgaggaa tgcatttcca tcagtgaaga atcaaccgga cctgttgcta gcaggcaatc   3335

tccatttctc agtgacagaa gcatgtttga gatgccgtgg gaaaccaaat atataataat   3395

aaaaatataa aaaggtgatg ttcaacagaa gtgaagacaa aacaatatgc atcaggagaa   3455

caagagtaaa cccagctccc actctcagtg ggctgcagtt gcccaaccac aggaagaaag   3515

ggaaggaggt agagggaaga aacagaagca gtgttccatt ttcttcctca ccaatgacat   3575

tcttttcttt tctcctttcg tactcctccc tgagagtccc ctcccttctc ccacactcgt   3635

ttccctttgc tcatgactcc tgtagggaag tttcttcaaa caaaacccag ctcctgagtc   3695

tccagatgtt gttctgtcag ttgccaaagg actttgctga ccactgcatg gggatccaac   3755

caattcaatt aatgtcttca tattgaagaa gagatgtacc ttcaattgaa aacctcgttt   3815

ttcttttgtt tgcattttct gcaaaaagga aaaagaaacc acaaattggg gaaaaaaaaa   3875

gaagaaaaac ctgtttccgt gtgcaaaagc acacatatgt atgtctgtgt tataaaatga   3935

ctgtgcttgt tcgtaacaga tgcaaacaag aaagaagaac tgggaagtct ttgtccctag   3995

gaaatccaaa ggggctggaa tatggtgttg gtttggcttt ctggttggcc caatcggcct   4055

attggctcaa tgggaagaga ggagagggag aaaaataaaa tgaaaggaaa aaaaaaagtt   4115

tgcaaattca gacaggaaac aggtgagtgg tttgaattgg atgcagtgtg ggccatcctg   4175

gaatgatact gactgattaa ttattcctga taacatctca agaaaaggag aaggaaagtg   4235

tttctggaga atgttctttc acatcactgg aatctgcaat tcaagaagtg acaagggaga   4295

attcttgctt tacctatgga ctggcttaag ccgtgtggca tccgaggaat gtttcaaatg   4355

tgtctgtgtt tctctttaca ttccttgttg tacctcattg ttcaattcac ttttgtaaat   4415

tccacctaac atttaattat tttaaatttc tccttttacc ttaatctcct tgctaatttt   4475

atctgtctaa ttaaaaagag cagaagcatg tctgggttta cgtaaaaaaa aaaaaaaaaa   4535

a                                                                   4536


<210>  14
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Leu Asp Tyr Leu Leu Leu Leu Leu Leu Ala Ser Ala Val Ala
1               5                   10                  15


Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu
            20                  25                  30


Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr
        35                  40                  45


Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe
    50                  55                  60


Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg
65                  70                  75                  80


Gly Ala His Arg Ile Tyr Thr Glu Met Arg Phe Thr Val Arg Asp Cys
                85                  90                  95


Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu
            100                 105                 110


Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe
        115                 120                 125


Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu
    130                 135                 140


Ser Phe Ser Gln Val Asp Phe Gly Gly Arg Leu Met Lys Val Asn Thr
145                 150                 155                 160


Glu Val Arg Ser Phe Gly Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala
                165                 170                 175


Phe Gln Asp Tyr Gly Ala Cys Met Ser Leu Leu Ser Val Arg Val Phe
            180                 185                 190


Phe Lys Lys Cys Pro Ser Ile Val Gln Asn Phe Ala Val Phe Pro Glu
        195                 200                 205


Thr Met Thr Gly Ala Glu Ser Thr Ser Leu Val Ile Ala Arg Gly Thr
    210                 215                 220


Cys Ile Pro Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys
225                 230                 235                 240


Asn Gly Asp Gly Glu Trp Met Val Pro Ile Gly Arg Cys Thr Cys Lys
                245                 250                 255


Pro Gly Tyr Glu Pro Glu Asn Ser Val Ala Cys Lys Ala Cys Pro Ala
            260                 265                 270


Gly Thr Phe Lys Ala Ser Gln Glu Ala Glu Gly Cys Ser His Cys Pro
        275                 280                 285


Ser Asn Ser Arg Ser Pro Ala Glu Ala Ser Pro Ile Cys Thr Cys Arg
    290                 295                 300


Thr Gly Tyr Tyr Arg Ala Asp Phe Asp Pro Pro Glu Val Ala Cys Thr
305                 310                 315                 320


Ser Val Pro Ser Gly Pro Arg Asn Val Ile Ser Ile Val Asn Glu Thr
                325                 330                 335


Ser Ile Ile Leu Glu Trp His Pro Pro Arg Glu Thr Gly Gly Arg Asp
            340                 345                 350


Asp Val Thr Tyr Asn Ile Ile Cys Lys Lys Cys Arg Ala Asp Arg Arg
        355                 360                 365


Ser Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro Arg Gln Leu
    370                 375                 380


Gly Leu Thr Glu Cys Arg Val Ser Ile Ser Ser Leu Trp Ala His Thr
385                 390                 395                 400


Pro Tyr Thr Phe Asp Ile Gln Ala Ile Asn Gly Val Ser Ser Lys Ser
                405                 410                 415


Pro Phe Pro Pro Gln His Val Ser Val Asn Ile Thr Thr Asn Gln Ala
            420                 425                 430


Ala Pro Ser Thr Val Pro Ile Met His Gln Val Ser Ala Thr Met Arg
        435                 440                 445


Ser Ile Thr Leu Ser Trp Pro Gln Pro Glu Gln Pro Asn Gly Ile Ile
    450                 455                 460


Leu Asp Tyr Glu Ile Arg Tyr Tyr Glu Lys Glu His Asn Glu Phe Asn
465                 470                 475                 480


Ser Ser Met Ala Arg Ser Gln Thr Asn Thr Ala Arg Ile Asp Gly Leu
                485                 490                 495


Arg Pro Gly Met Val Tyr Val Val Gln Val Arg Ala Arg Thr Val Ala
            500                 505                 510


Gly Tyr Gly Lys Phe Ser Gly Lys Met Cys Phe Gln Thr Leu Thr Asp
        515                 520                 525


Asp Asp Tyr Lys Ser Glu Leu Arg Glu Gln Leu Pro Leu Ile Ala Gly
    530                 535                 540


Ser Ala Ala Ala Gly Val Val Phe Val Val Ser Leu Val Ala Ile Ser
545                 550                 555                 560


Ile Val Cys Ser Arg Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser
                565                 570                 575


Asp Lys Leu Gln His Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys
            580                 585                 590


Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg
        595                 600                 605


Glu Phe Ala Lys Glu Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val
    610                 615                 620


Ile Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu
625                 630                 635                 640


Pro Gly Lys Arg Glu Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly
                645                 650                 655


Tyr Ser Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met
            660                 665                 670


Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr
        675                 680                 685


Lys Ser Arg Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala
    690                 695                 700


Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln
705                 710                 715                 720


Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala
                725                 730                 735


Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val
            740                 745                 750


Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr
        755                 760                 765


Leu Gln Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly
    770                 775                 780


Lys Ile Pro Val Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys
785                 790                 795                 800


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu
                805                 810                 815


Val Met Ser Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp
            820                 825                 830


Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp
        835                 840                 845


Cys Pro Ala Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp
    850                 855                 860


Arg Asn Ser Arg Pro Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys
865                 870                 875                 880


Met Ile Arg Asn Pro Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala
                885                 890                 895


Val Pro Ser Gln Pro Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala
            900                 905                 910


Phe Thr Thr Val Asp Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr
        915                 920                 925


Arg Asp Ser Phe Leu Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr
    930                 935                 940


Gln Met Thr Ser Glu Asp Leu Leu Arg Ile Gly Ile Thr Leu Ala Gly
945                 950                 955                 960


His Gln Lys Lys Ile Leu Asn Ser Ile His Ser Met Arg Val Gln Ile
                965                 970                 975


Ser Gln Ser Pro Thr Ala Met Ala
            980


<210>  15
<211>  4869
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (146)..(3109)

<400>  15
cattctgctg gctgcgcggt ggcggcggct gtgtgtgcgc cgcgccttgc cgccccccct     60

ggccccccga gcccggggcg cgcgctcccg cccgggccgt ccgggccccg cggcgccgcg    120

gcccgaggcc ccgggaagcg cagcc atg gct ctg cgg agg ctg ggg gcc gcg      172
                            Met Ala Leu Arg Arg Leu Gly Ala Ala
                            1               5

ctg ctg ctg ctg ccg ctg ctc gcc gcc gtg gaa gaa acg cta atg gac      220
Leu Leu Leu Leu Pro Leu Leu Ala Ala Val Glu Glu Thr Leu Met Asp
10                  15                  20                  25

tcc act aca gcg act gct gag ctg ggc tgg atg gtg cat cct cca tca      268
Ser Thr Thr Ala Thr Ala Glu Leu Gly Trp Met Val His Pro Pro Ser
                30                  35                  40

ggg tgg gaa gag gtg agt ggc tac gat gag aac atg aac acg atc cgc      316
Gly Trp Glu Glu Val Ser Gly Tyr Asp Glu Asn Met Asn Thr Ile Arg
            45                  50                  55

acg tac cag gtg tgc aac gtg ttt gag tca agc cag aac aac tgg cta      364
Thr Tyr Gln Val Cys Asn Val Phe Glu Ser Ser Gln Asn Asn Trp Leu
        60                  65                  70

cgg acc aag ttt atc cgg cgc cgt ggc gcc cac cgc atc cac gtg gag      412
Arg Thr Lys Phe Ile Arg Arg Arg Gly Ala His Arg Ile His Val Glu
    75                  80                  85

atg aag ttt tcg gtg cgt gac tgc agc agc atc ccc agc gtg cct ggc      460
Met Lys Phe Ser Val Arg Asp Cys Ser Ser Ile Pro Ser Val Pro Gly
90                  95                  100                 105

tcc tgc aag gag acc ttc aac ctc tat tac tat gag gct gac ttt gac      508
Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp
                110                 115                 120

tcg gcc acc aag acc ttc ccc aac tgg atg gag aat cca tgg gtg aag      556
Ser Ala Thr Lys Thr Phe Pro Asn Trp Met Glu Asn Pro Trp Val Lys
            125                 130                 135

gtg gat acc att gca gcc gac gag agc ttc tcc cag gtg gac ctg ggt      604
Val Asp Thr Ile Ala Ala Asp Glu Ser Phe Ser Gln Val Asp Leu Gly
        140                 145                 150

ggc cgc gtc atg aaa atc aac acc gag gtg cgg agc ttc gga cct gtg      652
Gly Arg Val Met Lys Ile Asn Thr Glu Val Arg Ser Phe Gly Pro Val
    155                 160                 165

tcc cgc agc ggc ttc tac ctg gcc ttc cag gac tat ggc ggc tgc atg      700
Ser Arg Ser Gly Phe Tyr Leu Ala Phe Gln Asp Tyr Gly Gly Cys Met
170                 175                 180                 185

tcc ctc atc gcc gtg cgt gtc ttc tac cgc aag tgc ccc cgc atc atc      748
Ser Leu Ile Ala Val Arg Val Phe Tyr Arg Lys Cys Pro Arg Ile Ile
                190                 195                 200

cag aat ggc gcc atc ttc cag gaa acc ctg tcg ggg gct gag agc aca      796
Gln Asn Gly Ala Ile Phe Gln Glu Thr Leu Ser Gly Ala Glu Ser Thr
            205                 210                 215

tcg ctg gtg gct gcc cgg ggc agc tgc atc gcc aat gcg gaa gag gtg      844
Ser Leu Val Ala Ala Arg Gly Ser Cys Ile Ala Asn Ala Glu Glu Val
        220                 225                 230

gat gta ccc atc aag ctc tac tgt aac ggg gac ggc gag tgg ctg gtg      892
Asp Val Pro Ile Lys Leu Tyr Cys Asn Gly Asp Gly Glu Trp Leu Val
    235                 240                 245

ccc atc ggg cgc tgc atg tgc aaa gca ggc ttc gag gcc gtt gag aat      940
Pro Ile Gly Arg Cys Met Cys Lys Ala Gly Phe Glu Ala Val Glu Asn
250                 255                 260                 265

ggc acc gtc tgc cga ggt tgt cca tct ggg act ttc aag gcc aac caa      988
Gly Thr Val Cys Arg Gly Cys Pro Ser Gly Thr Phe Lys Ala Asn Gln
                270                 275                 280

ggg gat gag gcc tgt acc cac tgt ccc atc aac agc cgg acc act tct     1036
Gly Asp Glu Ala Cys Thr His Cys Pro Ile Asn Ser Arg Thr Thr Ser
            285                 290                 295

gaa ggg gcc acc aac tgt gtc tgc cgc aat ggc tac tac aga gca gac     1084
Glu Gly Ala Thr Asn Cys Val Cys Arg Asn Gly Tyr Tyr Arg Ala Asp
        300                 305                 310

ctg gac ccc ctg gac atg ccc tgc aca acc atc ccc tcc gcg ccc cag     1132
Leu Asp Pro Leu Asp Met Pro Cys Thr Thr Ile Pro Ser Ala Pro Gln
    315                 320                 325

gct gtg att tcc agt gtc aat gag acc tcc ctc atg ctg gag tgg acc     1180
Ala Val Ile Ser Ser Val Asn Glu Thr Ser Leu Met Leu Glu Trp Thr
330                 335                 340                 345

cct ccc cgc gac tcc gga ggc cga gag gac ctc gtc tac aac atc atc     1228
Pro Pro Arg Asp Ser Gly Gly Arg Glu Asp Leu Val Tyr Asn Ile Ile
                350                 355                 360

tgc aag agc tgt ggc tcg ggc cgg ggt gcc tgc acc cgc tgc ggg gac     1276
Cys Lys Ser Cys Gly Ser Gly Arg Gly Ala Cys Thr Arg Cys Gly Asp
            365                 370                 375

aat gta cag tac gca cca cgc cag cta ggc ctg acc gag cca cgc att     1324
Asn Val Gln Tyr Ala Pro Arg Gln Leu Gly Leu Thr Glu Pro Arg Ile
        380                 385                 390

tac atc agt gac ctg ctg gcc cac acc cag tac acc ttc gag atc cag     1372
Tyr Ile Ser Asp Leu Leu Ala His Thr Gln Tyr Thr Phe Glu Ile Gln
    395                 400                 405

gct gtg aac ggc gtt act gac cag agc ccc ttc tcg cct cag ttc gcc     1420
Ala Val Asn Gly Val Thr Asp Gln Ser Pro Phe Ser Pro Gln Phe Ala
410                 415                 420                 425

tct gtg aac atc acc acc aac cag gca gct cca tcg gca gtg tcc atc     1468
Ser Val Asn Ile Thr Thr Asn Gln Ala Ala Pro Ser Ala Val Ser Ile
                430                 435                 440

atg cat cag gtg agc cgc acc gtg gac agc att acc ctg tcg tgg tcc     1516
Met His Gln Val Ser Arg Thr Val Asp Ser Ile Thr Leu Ser Trp Ser
            445                 450                 455

cag ccg gac cag ccc aat ggc gtg atc ctg gac tat gag ctg cag tac     1564
Gln Pro Asp Gln Pro Asn Gly Val Ile Leu Asp Tyr Glu Leu Gln Tyr
        460                 465                 470

tat gag aag gag ctc agt gag tac aac gcc aca gcc ata aaa agc ccc     1612
Tyr Glu Lys Glu Leu Ser Glu Tyr Asn Ala Thr Ala Ile Lys Ser Pro
    475                 480                 485

acc aac acg gtc acc gtg cag ggc ctc aaa gcc ggc gcc atc tat gtc     1660
Thr Asn Thr Val Thr Val Gln Gly Leu Lys Ala Gly Ala Ile Tyr Val
490                 495                 500                 505

ttc cag gtg cgg gca cgc acc gtg gca ggc tac ggg cgc tac agc ggc     1708
Phe Gln Val Arg Ala Arg Thr Val Ala Gly Tyr Gly Arg Tyr Ser Gly
                510                 515                 520

aag atg tac ttc cag acc atg aca gaa gcc gag tac cag aca agc atc     1756
Lys Met Tyr Phe Gln Thr Met Thr Glu Ala Glu Tyr Gln Thr Ser Ile
            525                 530                 535

cag gag aag ttg cca ctc atc atc ggc tcc tcg gcc gct ggc ctg gtc     1804
Gln Glu Lys Leu Pro Leu Ile Ile Gly Ser Ser Ala Ala Gly Leu Val
        540                 545                 550

ttc ctc att gct gtg gtt gtc atc gcc atc gtg tgt aac aga aga cgg     1852
Phe Leu Ile Ala Val Val Val Ile Ala Ile Val Cys Asn Arg Arg Arg
    555                 560                 565

ggg ttt gag cgt gct gac tcg gag tac acg gac aag ctg caa cac tac     1900
Gly Phe Glu Arg Ala Asp Ser Glu Tyr Thr Asp Lys Leu Gln His Tyr
570                 575                 580                 585

acc agt ggc cac atg acc cca ggc atg aag atc tac atc gat cct ttc     1948
Thr Ser Gly His Met Thr Pro Gly Met Lys Ile Tyr Ile Asp Pro Phe
                590                 595                 600

acc tac gag gac ccc aac gag gca gtg cgg gag ttt gcc aag gaa att     1996
Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys Glu Ile
            605                 610                 615

gac atc tcc tgt gtc aaa att gag cag gtg atc gga gca ggg gag ttt     2044
Asp Ile Ser Cys Val Lys Ile Glu Gln Val Ile Gly Ala Gly Glu Phe
        620                 625                 630

ggc gag gtc tgc agt ggc cac ctg aag ctg cca ggc aag aga gag atc     2092
Gly Glu Val Cys Ser Gly His Leu Lys Leu Pro Gly Lys Arg Glu Ile
    635                 640                 645

ttt gtg gcc atc aag acg ctc aag tcg ggc tac acg gag aag cag cgc     2140
Phe Val Ala Ile Lys Thr Leu Lys Ser Gly Tyr Thr Glu Lys Gln Arg
650                 655                 660                 665

cgg gac ttc ctg agc gaa gcc tcc atc atg ggc cag ttc gac cat ccc     2188
Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro
                670                 675                 680

aac gtc atc cac ctg gag ggt gtc gtg acc aag agc aca cct gtg atg     2236
Asn Val Ile His Leu Glu Gly Val Val Thr Lys Ser Thr Pro Val Met
            685                 690                 695

atc atc acc gag ttc atg gag aat ggc tcc ctg gac tcc ttt ctc cgg     2284
Ile Ile Thr Glu Phe Met Glu Asn Gly Ser Leu Asp Ser Phe Leu Arg
        700                 705                 710

caa aac gat ggg cag ttc aca gtc atc cag ctg gtg ggc atg ctt cgg     2332
Gln Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu Arg
    715                 720                 725

ggc atc gca gct ggc atg aag tac ctg gca gac atg aac tat gtt cac     2380
Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asp Met Asn Tyr Val His
730                 735                 740                 745

cgt gac ctg gct gcc cgc aac atc ctc gtc aac agc aac ctg gtc tgc     2428
Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val Cys
                750                 755                 760

aag gtg tcg gac ttt ggg ctc tca cgc ttt cta gag gac gat acc tca     2476
Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Asp Asp Thr Ser
            765                 770                 775

gac ccc acc tac acc agt gcc ctg ggc gga aag atc ccc atc cgc tgg     2524
Asp Pro Thr Tyr Thr Ser Ala Leu Gly Gly Lys Ile Pro Ile Arg Trp
        780                 785                 790

aca gcc ccg gaa gcc atc cag tac cgg aag ttc acc tcg gcc agt gat     2572
Thr Ala Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala Ser Asp
    795                 800                 805

gtg tgg agc tac ggc att gtc atg tgg gag gtg atg tcc tat ggg gag     2620
Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr Gly Glu
810                 815                 820                 825

cgg ccc tac tgg gac atg acc aac cag gat gta atc aat gcc att gag     2668
Arg Pro Tyr Trp Asp Met Thr Asn Gln Asp Val Ile Asn Ala Ile Glu
                830                 835                 840

cag gac tat cgg ctg cca ccg ccc atg gac tgc ccg agc gcc ctg cac     2716
Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro Ser Ala Leu His
            845                 850                 855

caa ctc atg ctg gac tgt tgg cag aag gac cgc aac cac cgg ccc aag     2764
Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn His Arg Pro Lys
        860                 865                 870

ttc ggc caa att gtc aac acg cta gac aag atg atc cgc aat ccc aac     2812
Phe Gly Gln Ile Val Asn Thr Leu Asp Lys Met Ile Arg Asn Pro Asn
    875                 880                 885

agc ctc aaa gcc atg gcg ccc ctc tcc tct ggc atc aac ctg ccg ctg     2860
Ser Leu Lys Ala Met Ala Pro Leu Ser Ser Gly Ile Asn Leu Pro Leu
890                 895                 900                 905

ctg gac cgc acg atc ccc gac tac acc agc ttt aac acg gtg gac gag     2908
Leu Asp Arg Thr Ile Pro Asp Tyr Thr Ser Phe Asn Thr Val Asp Glu
                910                 915                 920

tgg ctg gag gcc atc aag atg ggg cag tac aag gag agc ttc gcc aat     2956
Trp Leu Glu Ala Ile Lys Met Gly Gln Tyr Lys Glu Ser Phe Ala Asn
            925                 930                 935

gcc ggc ttc acc tcc ttt gac gtc gtg tct cag atg atg atg gag gac     3004
Ala Gly Phe Thr Ser Phe Asp Val Val Ser Gln Met Met Met Glu Asp
        940                 945                 950

att ctc cgg gtt ggg gtc act ttg gct ggc cac cag aaa aaa atc ctg     3052
Ile Leu Arg Val Gly Val Thr Leu Ala Gly His Gln Lys Lys Ile Leu
    955                 960                 965

aac agt atc cag gtg atg cgg gcg cag atg aac cag att cag tct gtg     3100
Asn Ser Ile Gln Val Met Arg Ala Gln Met Asn Gln Ile Gln Ser Val
970                 975                 980                 985

gag gtt tga cattcacctg cctcggctca cctcttcctc caagccccgc             3149
Glu Val


cccctctgcc ccacgtgccg gccctcctgg tgctctatcc actgcagggc cagccactcg   3209

ccaggaggcc acgggccacg ggaagaacca agcggtgcca gccacgagac gtcaccaaga   3269

aaacatgcaa ctcaaacgac ggaaaaaaaa agggaatggg aaaaaagaaa acagatcctg   3329

ggagggggcg ggaaatacaa ggaatatttt ttaaagagga ttctcataag gaaagcaatg   3389

actgttcttg cgggggataa aaaagggctt gggagattca tgcgatgtgt ccaatcggag   3449

acaaaagcag tttctctcca actccctctg ggaaggtgac ctggccagag ccaagaaaca   3509

ctttcagaaa aacaaatgtg aaggggagag acaggggccg cccttggctc ctgtccctgc   3569

tgctcctcta ggcctcactc aacaaccaag cgcctggagg acgggacaga tggacagaca   3629

gccaccctga gaacccctct gggaaaatct attcctgcca ccactgggca aacagaagaa   3689

tttttctgtc tttggagagt attttagaaa ctccaatgaa agacactgtt tctcctgttg   3749

gctcacaggg ctgaaagggg cttttgtcct cctgggtcag ggagaacgcg gggaccccag   3809

aaaggtcagc cttcctgagg atgggcaacc cccaggtctg cagctccagg tacatatcac   3869

gcgcacagcc tggcagcctg gccctcctgg tgcccactcc cgccagcccc tgcctcgagg   3929

actgatactg cagtgactgc cgtcagctcc gactgccgct gagaagggtt gatcctgcat   3989

ctgggtttgt ttacagcaat tcctggactc gggggtattt tggtcacagg gtggttttgg   4049

tttagggggt ttgtttgttg ggttgttttt tgttttttgg ttttttttaa tgacaatgaa   4109

gtgacacttt gacatttcct accttttgag gacttgatcc ttctccagga agaaggtgct   4169

ttctgcttac tgacttaggc aatacaccaa gggcgagatt ttatatgcac atttctggat   4229

ttttttatac ggttttcatt gacactcttc cctcctccca cctgccacca ggcctcacca   4289

aagcccactg ccatggggcc atctgggcca ttcagagact ggagtgagat ttgggtgtgg   4349

agggggaggc gccaaggtgg aggagcttcc cactccagga ctgttgatga aagggacaga   4409

ttgaggagga agtgggctct gaggctgcag ggctggaagt ccttgcccac ttcccactct   4469

cctgccccaa tctatctagt acttcccagg caaataggcc cctttgaggc tcctgagtgc   4529

cctcagatgg tcaaaaccca gttttccctc tgggagccta aaccaggctg catcggaggc   4589

caggacccgg atcattcact gtgataccct gccctccaga gggtgcgctc agagacacgg   4649

gcaagcatgc ctcttccctt ccctggagag aaagtgtgtg atttctctcc cacctccttc   4709

cccccaccag acctttgctg ggcctaaagg tcttggccat ggggacgccc tcagtctagg   4769

gatctggcca cagactccct cctgtgaacc aacacagaca cccaagcaga gcaatcagtt   4829

agtgaattga atggaaataa acgctttagt tataatatga                         4869


<210>  16
<211>  987
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu
1               5                   10                  15


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu
            20                  25                  30


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly
        35                  40                  45


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val
    50                  55                  60


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg
65                  70                  75                  80


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp
                85                  90                  95


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn
            100                 105                 110


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro
        115                 120                 125


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp
    130                 135                 140


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn
145                 150                 155                 160


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu
                165                 170                 175


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val
            180                 185                 190


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln
        195                 200                 205


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly
    210                 215                 220


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr
225                 230                 235                 240


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys
                245                 250                 255


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys
            260                 265                 270


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His
        275                 280                 285


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val
    290                 295                 300


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro
305                 310                 315                 320


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn
                325                 330                 335


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly
            340                 345                 350


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly
        355                 360                 365


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg
    370                 375                 380


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala
385                 390                 395                 400


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp
                405                 410                 415


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn
            420                 425                 430


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr
        435                 440                 445


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly
    450                 455                 460


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu
465                 470                 475                 480


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln
                485                 490                 495


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr
            500                 505                 510


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met
        515                 520                 525


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile
    530                 535                 540


Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val
545                 550                 555                 560


Ile Ala Ile Val Cys Asn Arg Arg Arg Gly Phe Glu Arg Ala Asp Ser
                565                 570                 575


Glu Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro
            580                 585                 590


Gly Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu
        595                 600                 605


Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile
    610                 615                 620


Glu Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His
625                 630                 635                 640


Leu Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu
                645                 650                 655


Lys Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala
            660                 665                 670


Ser Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly
        675                 680                 685


Val Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu
    690                 695                 700


Asn Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr
705                 710                 715                 720


Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys
                725                 730                 735


Tyr Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn
            740                 745                 750


Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu
        755                 760                 765


Ser Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala
    770                 775                 780


Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln
785                 790                 795                 800


Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val
                805                 810                 815


Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr
            820                 825                 830


Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro
        835                 840                 845


Pro Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp
    850                 855                 860


Gln Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr
865                 870                 875                 880


Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro
                885                 890                 895


Leu Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp
            900                 905                 910


Tyr Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met
        915                 920                 925


Gly Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp
    930                 935                 940


Val Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr
945                 950                 955                 960


Leu Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg
                965                 970                 975


Ala Gln Met Asn Gln Ile Gln Ser Val Glu Val
            980                 985


<210>  17
<211>  4234
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (438)..(3434)

<400>  17
cgtgagcggc gcagcaagat cccagctcgg accccggacg gcgcgcgccc ccgaagcccc     60

ggatcccagt cgggcccgca gctgaccgcc agattactgt gcatcccgaa tcacgaccac    120

ctgcaccctc ctgccccggc ccgcccccca agtcctcagg cacccagctc cccggcgccc    180

cggatcctcc tggaccggtc cgtccagatt cccgcgggac cgacctgtcc gcatccccag    240

gaccgccggg ctcggtgcac cgcctcggtc ccggagccgc ccgcctggat tgcattccct    300

cctctcctgg atctcctggg acccgacgcg agcctgcccc ggagcccgcc gagcgcaccc    360

tctctcgggt gcctgcagcc ccgccggcgc ggcccggccc ggcgcggccc ggctcggctc    420

ctagagctgc cacggcc atg gcc aga gcc cgc ccg ccg ccg ccg ccg tcg       470
                   Met Ala Arg Ala Arg Pro Pro Pro Pro Pro Ser
                   1               5                   10

ccg ccg ccg ggg ctt ctg ccg ctg ctc cct ccg ctg ctg ctg ctg ccg      518
Pro Pro Pro Gly Leu Leu Pro Leu Leu Pro Pro Leu Leu Leu Leu Pro
            15                  20                  25

ctg ctg ctg ctg ccc gcc ggc tgc cgg gcg ctg gaa gag acc ctc atg      566
Leu Leu Leu Leu Pro Ala Gly Cys Arg Ala Leu Glu Glu Thr Leu Met
        30                  35                  40

gac aca aaa tgg gta aca tct gag ttg gcg tgg aca tct cat cca gaa      614
Asp Thr Lys Trp Val Thr Ser Glu Leu Ala Trp Thr Ser His Pro Glu
    45                  50                  55

agt ggg tgg gaa gag gtg agt ggc tac gat gag gcc atg aat ccc atc      662
Ser Gly Trp Glu Glu Val Ser Gly Tyr Asp Glu Ala Met Asn Pro Ile
60                  65                  70                  75

cgc aca tac cag gtg tgt aat gtg cgc gag tca agc cag aac aac tgg      710
Arg Thr Tyr Gln Val Cys Asn Val Arg Glu Ser Ser Gln Asn Asn Trp
                80                  85                  90

ctt cgc acg ggg ttc atc tgg cgg cgg gat gtg cag cgg gtc tac gtg      758
Leu Arg Thr Gly Phe Ile Trp Arg Arg Asp Val Gln Arg Val Tyr Val
            95                  100                 105

gag ctc aag ttc act gtg cgt gac tgc aac agc atc ccc aac atc ccc      806
Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Ile Pro Asn Ile Pro
        110                 115                 120

ggc tcc tgc aag gag acc ttc aac ctc ttc tac tac gag gct gac agc      854
Gly Ser Cys Lys Glu Thr Phe Asn Leu Phe Tyr Tyr Glu Ala Asp Ser
    125                 130                 135

gat gtg gcc tca gcc tcc tcc ccc ttc tgg atg gag aac ccc tac gtg      902
Asp Val Ala Ser Ala Ser Ser Pro Phe Trp Met Glu Asn Pro Tyr Val
140                 145                 150                 155

aaa gtg gac acc att gca ccc gat gag agc ttc tcg cgg ctg gat gcc      950
Lys Val Asp Thr Ile Ala Pro Asp Glu Ser Phe Ser Arg Leu Asp Ala
                160                 165                 170

ggc cgt gtc aac acc aag gtg cgc agc ttt ggg cca ctt tcc aag gct      998
Gly Arg Val Asn Thr Lys Val Arg Ser Phe Gly Pro Leu Ser Lys Ala
            175                 180                 185

ggc ttc tac ctg gcc ttc cag gac cag ggc gcc tgc atg tcg ctc atc     1046
Gly Phe Tyr Leu Ala Phe Gln Asp Gln Gly Ala Cys Met Ser Leu Ile
        190                 195                 200

tcc gtg cgc gcc ttc tac aag aag tgt gca tcc acc acc gca ggc ttc     1094
Ser Val Arg Ala Phe Tyr Lys Lys Cys Ala Ser Thr Thr Ala Gly Phe
    205                 210                 215

gca ctc ttc ccc gag acc ctc act ggg gcg gag ccc acc tcg ctg gtc     1142
Ala Leu Phe Pro Glu Thr Leu Thr Gly Ala Glu Pro Thr Ser Leu Val
220                 225                 230                 235

att gct cct ggc acc tgc atc cct aac gcc gtg gag gtg tcg gtg cca     1190
Ile Ala Pro Gly Thr Cys Ile Pro Asn Ala Val Glu Val Ser Val Pro
                240                 245                 250

ctc aag ctc tac tgc aac ggc gat ggg gag tgg atg gtg cct gtg ggt     1238
Leu Lys Leu Tyr Cys Asn Gly Asp Gly Glu Trp Met Val Pro Val Gly
            255                 260                 265

gcc tgc acc tgt gcc acc ggc cat gag cca gct gcc aag gag tcc cag     1286
Ala Cys Thr Cys Ala Thr Gly His Glu Pro Ala Ala Lys Glu Ser Gln
        270                 275                 280

tgc cgc ccc tgt ccc cct ggg agc tac aag gcg aag cag gga gag ggg     1334
Cys Arg Pro Cys Pro Pro Gly Ser Tyr Lys Ala Lys Gln Gly Glu Gly
    285                 290                 295

ccc tgc ctc cca tgt ccc ccc aac agc cgt acc acc tcc cca gcc gcc     1382
Pro Cys Leu Pro Cys Pro Pro Asn Ser Arg Thr Thr Ser Pro Ala Ala
300                 305                 310                 315

agc atc tgc acc tgc cac aat aac ttc tac cgt gca gac tcg gac tct     1430
Ser Ile Cys Thr Cys His Asn Asn Phe Tyr Arg Ala Asp Ser Asp Ser
                320                 325                 330

gcg gac agt gcc tgt acc acc gtg cca tct cca ccc cga ggt gtg atc     1478
Ala Asp Ser Ala Cys Thr Thr Val Pro Ser Pro Pro Arg Gly Val Ile
            335                 340                 345

tcc aat gtg aat gaa acc tca ctg atc ctc gag tgg agt gag ccc cgg     1526
Ser Asn Val Asn Glu Thr Ser Leu Ile Leu Glu Trp Ser Glu Pro Arg
        350                 355                 360

gac ctg ggt ggc cgg gat gac ctc ctg tac aat gtc atc tgc aag aag     1574
Asp Leu Gly Gly Arg Asp Asp Leu Leu Tyr Asn Val Ile Cys Lys Lys
    365                 370                 375

tgc cat ggg gct gga ggg gcc tca gcc tgc tca cgc tgt gat gac aac     1622
Cys His Gly Ala Gly Gly Ala Ser Ala Cys Ser Arg Cys Asp Asp Asn
380                 385                 390                 395

gtg gag ttt gtg cct cgg cag ctg ggc ctg acg gag cgc cgg gtc cac     1670
Val Glu Phe Val Pro Arg Gln Leu Gly Leu Thr Glu Arg Arg Val His
                400                 405                 410

atc agc cat ctg ctg gcc cac acg cgc tac acc ttt gag gtg cag gcg     1718
Ile Ser His Leu Leu Ala His Thr Arg Tyr Thr Phe Glu Val Gln Ala
            415                 420                 425

gtc aac ggt gtc tcg ggc aag agc cct ctg ccg cct cgt tat gcg gcc     1766
Val Asn Gly Val Ser Gly Lys Ser Pro Leu Pro Pro Arg Tyr Ala Ala
        430                 435                 440

gtg aat atc acc aca aac cag gct gcc ccg tct gaa gtg ccc aca cta     1814
Val Asn Ile Thr Thr Asn Gln Ala Ala Pro Ser Glu Val Pro Thr Leu
    445                 450                 455

cgc ctg cac agc agc tca ggc agc agc ctc acc cta tcc tgg gca ccc     1862
Arg Leu His Ser Ser Ser Gly Ser Ser Leu Thr Leu Ser Trp Ala Pro
460                 465                 470                 475

cca gag cgg ccc aac gga gtc atc ctg gac tac gag atg aag tac ttt     1910
Pro Glu Arg Pro Asn Gly Val Ile Leu Asp Tyr Glu Met Lys Tyr Phe
                480                 485                 490

gag aag agc gag ggc atc gcc tcc aca gtg acc agc cag atg aac tcc     1958
Glu Lys Ser Glu Gly Ile Ala Ser Thr Val Thr Ser Gln Met Asn Ser
            495                 500                 505

gtg cag ctg gac ggg ctt cgg cct gac gcc cgc tat gtg gtc cag gtc     2006
Val Gln Leu Asp Gly Leu Arg Pro Asp Ala Arg Tyr Val Val Gln Val
        510                 515                 520

cgt gcc cgc aca gta gct ggc tat ggg cag tac agc cgc cct gcc gag     2054
Arg Ala Arg Thr Val Ala Gly Tyr Gly Gln Tyr Ser Arg Pro Ala Glu
    525                 530                 535

ttt gag acc aca agt gag aga ggc tct ggg gcc cag cag ctc cag gag     2102
Phe Glu Thr Thr Ser Glu Arg Gly Ser Gly Ala Gln Gln Leu Gln Glu
540                 545                 550                 555

cag ctt ccc ctc atc gtg ggc tcc gct aca gct ggg ctt gtc ttc gtg     2150
Gln Leu Pro Leu Ile Val Gly Ser Ala Thr Ala Gly Leu Val Phe Val
                560                 565                 570

gtg gct gtc gtg gtc atc gct atc gtc tgc ctc agg aag cag cga cac     2198
Val Ala Val Val Val Ile Ala Ile Val Cys Leu Arg Lys Gln Arg His
            575                 580                 585

ggc tct gat tcg gag tac acg gag aag ctg cag cag tac att gct cct     2246
Gly Ser Asp Ser Glu Tyr Thr Glu Lys Leu Gln Gln Tyr Ile Ala Pro
        590                 595                 600

gga atg aag gtt tat att gac cct ttt acc tac gag gac cct aat gag     2294
Gly Met Lys Val Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu
    605                 610                 615

gct gtt cgg gag ttt gcc aag gag atc gac gtg tcc tgc gtc aag atc     2342
Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Val Ser Cys Val Lys Ile
620                 625                 630                 635

gag gag gtg atc gga gct ggg gaa ttt ggg gaa gtg tgc cgt ggt cga     2390
Glu Glu Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Arg Gly Arg
                640                 645                 650

ctg aaa cag cct ggc cgc cga gag gtg ttt gtg gcc atc aag acg ctg     2438
Leu Lys Gln Pro Gly Arg Arg Glu Val Phe Val Ala Ile Lys Thr Leu
            655                 660                 665

aag gtg ggc tac acc gag agg cag cgg cgg gac ttc cta agc gag gcc     2486
Lys Val Gly Tyr Thr Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala
        670                 675                 680

tcc atc atg ggt cag ttt gat cac ccc aat ata atc cgg ctc gag ggc     2534
Ser Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly
    685                 690                 695

gtg gtc acc aaa agt cgg cca gtt atg atc ctc act gag ttc atg gaa     2582
Val Val Thr Lys Ser Arg Pro Val Met Ile Leu Thr Glu Phe Met Glu
700                 705                 710                 715

aac tgc gcc ctg gac tcc ttc ctc cgg ctc aac gat ggg cag ttc acg     2630
Asn Cys Ala Leu Asp Ser Phe Leu Arg Leu Asn Asp Gly Gln Phe Thr
                720                 725                 730

gtc atc cag ctg gtg ggc atg ttg cgg ggc att gct gcc ggc atg aag     2678
Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys
            735                 740                 745

tac ctg tcc gag atg aac tat gtg cac cgc gac ctg gct gct cgc aac     2726
Tyr Leu Ser Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn
        750                 755                 760

atc ctt gtc aac agc aac ctg gtc tgc aaa gtc tca gac ttt ggc ctc     2774
Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu
    765                 770                 775

tcc cgc ttc ctg gag gat gac ccc tcc gat cct acc tac acc agt tcc     2822
Ser Arg Phe Leu Glu Asp Asp Pro Ser Asp Pro Thr Tyr Thr Ser Ser
780                 785                 790                 795

ctg ggc ggg aag atc ccc atc cgc tgg act gcc cca gag gcc ata gcc     2870
Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala
                800                 805                 810

tat cgg aag ttc act tct gct agt gat gtc tgg agc tac gga att gtc     2918
Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val
            815                 820                 825

atg tgg gag gtc atg agc tat gga gag cga ccc tac tgg gac atg agc     2966
Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser
        830                 835                 840

aac cag gat gtc atc aat gcc gtg gag cag gat tac cgg ctg cca cca     3014
Asn Gln Asp Val Ile Asn Ala Val Glu Gln Asp Tyr Arg Leu Pro Pro
    845                 850                 855

ccc atg gac tgt ccc aca gca ctg cac cag ctc atg ctg gac tgc tgg     3062
Pro Met Asp Cys Pro Thr Ala Leu His Gln Leu Met Leu Asp Cys Trp
860                 865                 870                 875

gtg cgg gac cgg aac ctc agg ccc aaa ttc tcc cag att gtc aat acc     3110
Val Arg Asp Arg Asn Leu Arg Pro Lys Phe Ser Gln Ile Val Asn Thr
                880                 885                 890

ctg gac aag ctc atc cgc aat gct gcc agc ctc aag gtc att gcc agc     3158
Leu Asp Lys Leu Ile Arg Asn Ala Ala Ser Leu Lys Val Ile Ala Ser
            895                 900                 905

gct cag tct ggc atg tca cag ccc ctc ctg gac cgc acg gtc cca gat     3206
Ala Gln Ser Gly Met Ser Gln Pro Leu Leu Asp Arg Thr Val Pro Asp
        910                 915                 920

tac aca acc ttc acg aca gtt ggt gat tgg ctg gat gcc atc aag atg     3254
Tyr Thr Thr Phe Thr Thr Val Gly Asp Trp Leu Asp Ala Ile Lys Met
    925                 930                 935

ggg cgg tac aag gag agc ttc gtc agt gcg ggg ttt gca tct ttt gac     3302
Gly Arg Tyr Lys Glu Ser Phe Val Ser Ala Gly Phe Ala Ser Phe Asp
940                 945                 950                 955

ctg gtg gcc cag atg acg gca gaa gac ctg ctc cgt att ggg gtc acc     3350
Leu Val Ala Gln Met Thr Ala Glu Asp Leu Leu Arg Ile Gly Val Thr
                960                 965                 970

ctg gcc ggc cac cag aag aag atc ctg agc agt atc cag gac atg cgg     3398
Leu Ala Gly His Gln Lys Lys Ile Leu Ser Ser Ile Gln Asp Met Arg
            975                 980                 985

ctg cag atg aac cag acg ctg cct gtg cag gtc tga caccggctcc          3444
Leu Gln Met Asn Gln Thr Leu Pro Val Gln Val
        990                 995

cacggggacc ctgaggaccg tgcagggatg ccaagcagcc ggctggactt tcggactctt   3504

ggacttttgg atgcctggcc ttaggctgtg gcccagaagc tggaagtttg ggaaaggccc   3564

aagctgggac ttctccaggc ctgtgttccc tccccaggaa gtgcgcccca aacctcttca   3624

tattgaagat ggattaggag agggggtgat gacccctccc caagcccctc agggcccaga   3684

ccttcctgct ctccagcagg ggatccccac aacctcacac ttgtctgttc ttcagtgctg   3744

gaggtcctgg cagggtcagg ctggggtaag ccggggttcc acagggccca gccctggcag   3804

gggtctggcc ccccaggtag gcggagagca gtccctccct caggaactgg aggaggggac   3864

tccaggaatg gggaaatgtg acaccaccat cctgaagcca gcttgcacct ccagtttgca   3924

cagggatttg ttctgggggc tgagggccct gtccccaccc ccgcccttgg tgctgtcata   3984

aaagggcagg caggggcagg ctgaggagtt gccctttgcc ccccagagac tgactctcag   4044

agccagagat gggatgtgtg agtgtgtgtg tgtgtgtgtg tgtgtgcgcg cgcgcgcgcg   4104

tgtgtgtgtg cacgcactgg cctgcacaga gagcatgggt gagcgtgtaa aagcttggcc   4164

ctgtgcccta caatggggcc agctgggccg acagcagaat aaaggcaata agatgaaaaa   4224

aaaaaaaaaa                                                          4234


<210>  18
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Arg Ala Arg Pro Pro Pro Pro Pro Ser Pro Pro Pro Gly Leu
1               5                   10                  15


Leu Pro Leu Leu Pro Pro Leu Leu Leu Leu Pro Leu Leu Leu Leu Pro
            20                  25                  30


Ala Gly Cys Arg Ala Leu Glu Glu Thr Leu Met Asp Thr Lys Trp Val
        35                  40                  45


Thr Ser Glu Leu Ala Trp Thr Ser His Pro Glu Ser Gly Trp Glu Glu
    50                  55                  60


Val Ser Gly Tyr Asp Glu Ala Met Asn Pro Ile Arg Thr Tyr Gln Val
65                  70                  75                  80


Cys Asn Val Arg Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Gly Phe
                85                  90                  95


Ile Trp Arg Arg Asp Val Gln Arg Val Tyr Val Glu Leu Lys Phe Thr
            100                 105                 110


Val Arg Asp Cys Asn Ser Ile Pro Asn Ile Pro Gly Ser Cys Lys Glu
        115                 120                 125


Thr Phe Asn Leu Phe Tyr Tyr Glu Ala Asp Ser Asp Val Ala Ser Ala
    130                 135                 140


Ser Ser Pro Phe Trp Met Glu Asn Pro Tyr Val Lys Val Asp Thr Ile
145                 150                 155                 160


Ala Pro Asp Glu Ser Phe Ser Arg Leu Asp Ala Gly Arg Val Asn Thr
                165                 170                 175


Lys Val Arg Ser Phe Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu Ala
            180                 185                 190


Phe Gln Asp Gln Gly Ala Cys Met Ser Leu Ile Ser Val Arg Ala Phe
        195                 200                 205


Tyr Lys Lys Cys Ala Ser Thr Thr Ala Gly Phe Ala Leu Phe Pro Glu
    210                 215                 220


Thr Leu Thr Gly Ala Glu Pro Thr Ser Leu Val Ile Ala Pro Gly Thr
225                 230                 235                 240


Cys Ile Pro Asn Ala Val Glu Val Ser Val Pro Leu Lys Leu Tyr Cys
                245                 250                 255


Asn Gly Asp Gly Glu Trp Met Val Pro Val Gly Ala Cys Thr Cys Ala
            260                 265                 270


Thr Gly His Glu Pro Ala Ala Lys Glu Ser Gln Cys Arg Pro Cys Pro
        275                 280                 285


Pro Gly Ser Tyr Lys Ala Lys Gln Gly Glu Gly Pro Cys Leu Pro Cys
    290                 295                 300


Pro Pro Asn Ser Arg Thr Thr Ser Pro Ala Ala Ser Ile Cys Thr Cys
305                 310                 315                 320


His Asn Asn Phe Tyr Arg Ala Asp Ser Asp Ser Ala Asp Ser Ala Cys
                325                 330                 335


Thr Thr Val Pro Ser Pro Pro Arg Gly Val Ile Ser Asn Val Asn Glu
            340                 345                 350


Thr Ser Leu Ile Leu Glu Trp Ser Glu Pro Arg Asp Leu Gly Gly Arg
        355                 360                 365


Asp Asp Leu Leu Tyr Asn Val Ile Cys Lys Lys Cys His Gly Ala Gly
    370                 375                 380


Gly Ala Ser Ala Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro
385                 390                 395                 400


Arg Gln Leu Gly Leu Thr Glu Arg Arg Val His Ile Ser His Leu Leu
                405                 410                 415


Ala His Thr Arg Tyr Thr Phe Glu Val Gln Ala Val Asn Gly Val Ser
            420                 425                 430


Gly Lys Ser Pro Leu Pro Pro Arg Tyr Ala Ala Val Asn Ile Thr Thr
        435                 440                 445


Asn Gln Ala Ala Pro Ser Glu Val Pro Thr Leu Arg Leu His Ser Ser
    450                 455                 460


Ser Gly Ser Ser Leu Thr Leu Ser Trp Ala Pro Pro Glu Arg Pro Asn
465                 470                 475                 480


Gly Val Ile Leu Asp Tyr Glu Met Lys Tyr Phe Glu Lys Ser Glu Gly
                485                 490                 495


Ile Ala Ser Thr Val Thr Ser Gln Met Asn Ser Val Gln Leu Asp Gly
            500                 505                 510


Leu Arg Pro Asp Ala Arg Tyr Val Val Gln Val Arg Ala Arg Thr Val
        515                 520                 525


Ala Gly Tyr Gly Gln Tyr Ser Arg Pro Ala Glu Phe Glu Thr Thr Ser
    530                 535                 540


Glu Arg Gly Ser Gly Ala Gln Gln Leu Gln Glu Gln Leu Pro Leu Ile
545                 550                 555                 560


Val Gly Ser Ala Thr Ala Gly Leu Val Phe Val Val Ala Val Val Val
                565                 570                 575


Ile Ala Ile Val Cys Leu Arg Lys Gln Arg His Gly Ser Asp Ser Glu
            580                 585                 590


Tyr Thr Glu Lys Leu Gln Gln Tyr Ile Ala Pro Gly Met Lys Val Tyr
        595                 600                 605


Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe
    610                 615                 620


Ala Lys Glu Ile Asp Val Ser Cys Val Lys Ile Glu Glu Val Ile Gly
625                 630                 635                 640


Ala Gly Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Gln Pro Gly
                645                 650                 655


Arg Arg Glu Val Phe Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr
            660                 665                 670


Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln
        675                 680                 685


Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Ser
    690                 695                 700


Arg Pro Val Met Ile Leu Thr Glu Phe Met Glu Asn Cys Ala Leu Asp
705                 710                 715                 720


Ser Phe Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val
                725                 730                 735


Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ser Glu Met
            740                 745                 750


Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser
        755                 760                 765


Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu
    770                 775                 780


Asp Asp Pro Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile
785                 790                 795                 800


Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr
                805                 810                 815


Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met
            820                 825                 830


Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile
        835                 840                 845


Asn Ala Val Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro
    850                 855                 860


Thr Ala Leu His Gln Leu Met Leu Asp Cys Trp Val Arg Asp Arg Asn
865                 870                 875                 880


Leu Arg Pro Lys Phe Ser Gln Ile Val Asn Thr Leu Asp Lys Leu Ile
                885                 890                 895


Arg Asn Ala Ala Ser Leu Lys Val Ile Ala Ser Ala Gln Ser Gly Met
            900                 905                 910


Ser Gln Pro Leu Leu Asp Arg Thr Val Pro Asp Tyr Thr Thr Phe Thr
        915                 920                 925


Thr Val Gly Asp Trp Leu Asp Ala Ile Lys Met Gly Arg Tyr Lys Glu
    930                 935                 940


Ser Phe Val Ser Ala Gly Phe Ala Ser Phe Asp Leu Val Ala Gln Met
945                 950                 955                 960


Thr Ala Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln
                965                 970                 975


Lys Lys Ile Leu Ser Ser Ile Gln Asp Met Arg Leu Gln Met Asn Gln
            980                 985                 990


Thr Leu Pro Val Gln Val
        995


<210>  19
<211>  4369
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (492)..(3455)

<400>  19
ttccagcgca gctcagcccc tgcccggccc ggcccgcccg gctccgcgcc gcagtctccc     60

tccctcccgc tccgtccccg ctcgggctcc caccatcccc gcccgcgagg agagcactcg    120

gcccggcggc gcgagcagag ccactccagg gaggggggga gaccgcgagc ggccggctca    180

gcccccgcca cccggggcgg gaccccgagg ccccggaggg accccaactc cagccacgtc    240

ttgctgcgcg cccgcccggc gcggccactg ccagcacgct ccgggcccgc cgcccgcgcg    300

cgcggcacag acgcggggcc acacttggcg ccgccgcccg gtgccccgca cgctcgcatg    360

ggcccgcgct gagggccccg acgaggagtc ccgcgcggag tatcggcgtc cacccgccca    420

gggagagtca gacctggggg ggcgagggcc ccccaaactc agttcggatc ctacccgagt    480

gaggcggcgc c atg gag ctc cgg gtg ctg ctc tgc tgg gct tcg ttg gcc     530
             Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala
             1               5                   10

gca gct ttg gaa gag acc ctg ctg aac aca aaa ttg gaa act gct gat      578
Ala Ala Leu Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp
    15                  20                  25

ctg aag tgg gtg aca ttc cct cag gtg gac ggg cag tgg gag gaa ctg      626
Leu Lys Trp Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu
30                  35                  40                  45

agc ggc ctg gat gag gaa cag cac agc gtg cgc acc tac gaa gtg tgt      674
Ser Gly Leu Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys
                50                  55                  60

gac gtg cag cgt gcc ccg ggc cag gcc cac tgg ctt cgc aca ggt tgg      722
Asp Val Gln Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp
            65                  70                  75

gtc cca cgg cgg ggc gcc gtc cac gtg tac gcc acg ctg cgc ttc acc      770
Val Pro Arg Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr
        80                  85                  90

atg ctc gag tgc ctg tcc ctg cct cgg gct ggg cgc tcc tgc aag gag      818
Met Leu Glu Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu
    95                  100                 105

acc ttc acc gtc ttc tac tat gag agc gat gcg gac acg gcc acg gcc      866
Thr Phe Thr Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala
110                 115                 120                 125

ctc acg cca gcc tgg atg gag aac ccc tac atc aag gtg gac acg gtg      914
Leu Thr Pro Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val
                130                 135                 140

gcc gcg gag cat ctc acc cgg aag cgc cct ggg gcc gag gcc acc ggg      962
Ala Ala Glu His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly
            145                 150                 155

aag gtg aat gtc aag acg ctg cgt ctg gga ccg ctc agc aag gct ggc     1010
Lys Val Asn Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly
        160                 165                 170

ttc tac ctg gcc ttc cag gac cag ggt gcc tgc atg gcc ctg cta tcc     1058
Phe Tyr Leu Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser
    175                 180                 185

ctg cac ctc ttc tac aaa aag tgc gcc cag ctg act gtg aac ctg act     1106
Leu His Leu Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr
190                 195                 200                 205

cga ttc ccg gag act gtg cct cgg gag ctg gtt gtg ccc gtg gcc ggt     1154
Arg Phe Pro Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly
                210                 215                 220

agc tgc gtg gtg gat gcc gtc ccc gcc cct ggc ccc agc ccc agc ctc     1202
Ser Cys Val Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu
            225                 230                 235

tac tgc cgt gag gat ggc cag tgg gcc gaa cag ccg gtc acg ggc tgc     1250
Tyr Cys Arg Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys
        240                 245                 250

agc tgt gct ccg ggg ttc gag gca gct gag ggg aac acc aag tgc cga     1298
Ser Cys Ala Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg
    255                 260                 265

gcc tgt gcc cag ggc acc ttc aag ccc ctg tca gga gaa ggg tcc tgc     1346
Ala Cys Ala Gln Gly Thr Phe Lys Pro Leu Ser Gly Glu Gly Ser Cys
270                 275                 280                 285

cag cca tgc cca gcc aat agc cac tct aac acc att gga tca gcc gtc     1394
Gln Pro Cys Pro Ala Asn Ser His Ser Asn Thr Ile Gly Ser Ala Val
                290                 295                 300

tgc cag tgc cgc gtc ggg tac ttc cgg gca cgc aca gac ccc cgg ggt     1442
Cys Gln Cys Arg Val Gly Tyr Phe Arg Ala Arg Thr Asp Pro Arg Gly
            305                 310                 315

gca ccc tgc acc acc cct cct tcg gct ccg cgg agc gtg gtt tcc cgc     1490
Ala Pro Cys Thr Thr Pro Pro Ser Ala Pro Arg Ser Val Val Ser Arg
        320                 325                 330

ctg aac ggc tcc tcc ctg cac ctg gaa tgg agt gcc ccc ctg gag tct     1538
Leu Asn Gly Ser Ser Leu His Leu Glu Trp Ser Ala Pro Leu Glu Ser
    335                 340                 345

ggt ggc cga gag gac ctc acc tac gcc ctc cgc tgc cgg gag tgc cga     1586
Gly Gly Arg Glu Asp Leu Thr Tyr Ala Leu Arg Cys Arg Glu Cys Arg
350                 355                 360                 365

ccc gga ggc tcc tgt gcg ccc tgc ggg gga gac ctg act ttt gac ccc     1634
Pro Gly Gly Ser Cys Ala Pro Cys Gly Gly Asp Leu Thr Phe Asp Pro
                370                 375                 380

ggc ccc cgg gac ctg gtg gag ccc tgg gtg gtg gtt cga ggg cta cgt     1682
Gly Pro Arg Asp Leu Val Glu Pro Trp Val Val Val Arg Gly Leu Arg
            385                 390                 395

cct gac ttc acc tat acc ttt gag gtc act gca ttg aac ggg gta tcc     1730
Pro Asp Phe Thr Tyr Thr Phe Glu Val Thr Ala Leu Asn Gly Val Ser
        400                 405                 410

tcc tta gcc acg ggg ccc gtc cca ttt gag cct gtc aat gtc acc act     1778
Ser Leu Ala Thr Gly Pro Val Pro Phe Glu Pro Val Asn Val Thr Thr
    415                 420                 425

gac cga gag gta cct cct gca gtg tct gac atc cgg gtg acg cgg tcc     1826
Asp Arg Glu Val Pro Pro Ala Val Ser Asp Ile Arg Val Thr Arg Ser
430                 435                 440                 445

tca ccc agc agc ttg agc ctg gcc tgg gct gtt ccc cgg gca ccc agt     1874
Ser Pro Ser Ser Leu Ser Leu Ala Trp Ala Val Pro Arg Ala Pro Ser
                450                 455                 460

ggg gct gtg ctg gac tac gag gtc aaa tac cat gag aag ggc gcc gag     1922
Gly Ala Val Leu Asp Tyr Glu Val Lys Tyr His Glu Lys Gly Ala Glu
            465                 470                 475

ggt ccc agc agc gtg cgg ttc ctg aag acg tca gaa aac cgg gca gag     1970
Gly Pro Ser Ser Val Arg Phe Leu Lys Thr Ser Glu Asn Arg Ala Glu
        480                 485                 490

ctg cgg ggg ctg aag cgg gga gcc agc tac ctg gtg cag gta cgg gcg     2018
Leu Arg Gly Leu Lys Arg Gly Ala Ser Tyr Leu Val Gln Val Arg Ala
    495                 500                 505

cgc tct gag gcc ggc tac ggg ccc ttc ggc cag gaa cat cac agc cag     2066
Arg Ser Glu Ala Gly Tyr Gly Pro Phe Gly Gln Glu His His Ser Gln
510                 515                 520                 525

acc caa ctg gat gag agc gag ggc tgg cgg gag cag ctg gcc ctg att     2114
Thr Gln Leu Asp Glu Ser Glu Gly Trp Arg Glu Gln Leu Ala Leu Ile
                530                 535                 540

gcg ggc acg gca gtc gtg ggt gtg gtc ctg gtc ctg gtg gtc att gtg     2162
Ala Gly Thr Ala Val Val Gly Val Val Leu Val Leu Val Val Ile Val
            545                 550                 555

gtc gca gtt ctc tgc ctc agg aag cag agc aat ggg aga gaa gca gaa     2210
Val Ala Val Leu Cys Leu Arg Lys Gln Ser Asn Gly Arg Glu Ala Glu
        560                 565                 570

tat tcg gac aaa cac gga cag tat ctc atc gga cat ggt act aag gtc     2258
Tyr Ser Asp Lys His Gly Gln Tyr Leu Ile Gly His Gly Thr Lys Val
    575                 580                 585

tac atc gac ccc ttc act tat gaa gac cct aat gag gct gtg agg gaa     2306
Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu
590                 595                 600                 605

ttt gca aaa gag atc gat gtc tcc tac gtc aag att gaa gag gtg att     2354
Phe Ala Lys Glu Ile Asp Val Ser Tyr Val Lys Ile Glu Glu Val Ile
                610                 615                 620

ggt gca ggt gag ttt ggc gag gtg tgc cgg ggg cgg ctc aag gcc cca     2402
Gly Ala Gly Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Ala Pro
            625                 630                 635

ggg aag aag gag agc tgt gtg gca atc aag acc ctg aag ggt ggc tac     2450
Gly Lys Lys Glu Ser Cys Val Ala Ile Lys Thr Leu Lys Gly Gly Tyr
        640                 645                 650

acg gag cgg cag cgg cgt gag ttt ctg agc gag gcc tcc atc atg ggc     2498
Thr Glu Arg Gln Arg Arg Glu Phe Leu Ser Glu Ala Ser Ile Met Gly
    655                 660                 665

cag ttc gag cac ccc aat atc atc cgc ctg gag ggc gtg gtc acc aac     2546
Gln Phe Glu His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Asn
670                 675                 680                 685

agc atg ccc gtc atg att ctc aca gag ttc atg gag aac ggc gcc ctg     2594
Ser Met Pro Val Met Ile Leu Thr Glu Phe Met Glu Asn Gly Ala Leu
                690                 695                 700

gac tcc ttc ctg cgg cta aac gac gga cag ttc aca gtc atc cag ctc     2642
Asp Ser Phe Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu
            705                 710                 715

gtg ggc atg ctg cgg ggc atc gcc tcg ggc atg cgg tac ctt gcc gag     2690
Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met Arg Tyr Leu Ala Glu
        720                 725                 730

atg agc tac gtc cac cga gac ctg gct gct cgc aac atc cta gtc aac     2738
Met Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn
    735                 740                 745

agc aac ctc gtc tgc aaa gtg tct gac ttt ggc ctt tcc cga ttc ctg     2786
Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu
750                 755                 760                 765

gag gag aac tct tcc gat ccc acc tac acg agc tcc ctg gga gga aag     2834
Glu Glu Asn Ser Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys
                770                 775                 780

att ccc atc cga tgg act gcc ccg gag gcc att gcc ttc cgg aag ttc     2882
Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Lys Phe
            785                 790                 795

act tcc gcc agt gat gcc tgg agt tac ggg att gtg atg tgg gag gtg     2930
Thr Ser Ala Ser Asp Ala Trp Ser Tyr Gly Ile Val Met Trp Glu Val
        800                 805                 810

atg tca ttt ggg gag agg ccg tac tgg gac atg agc aat cag gac gtg     2978
Met Ser Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val
    815                 820                 825

atc aat gcc att gaa cag gac tac cgg ctg ccc ccg ccc cca gac tgt     3026
Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Pro Asp Cys
830                 835                 840                 845

ccc acc tcc ctc cac cag ctc atg ctg gac tgt tgg cag aaa gac cgg     3074
Pro Thr Ser Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg
                850                 855                 860

aat gcc cgg ccc cgc ttc ccc cag gtg gtc agc gcc ctg gac aag atg     3122
Asn Ala Arg Pro Arg Phe Pro Gln Val Val Ser Ala Leu Asp Lys Met
            865                 870                 875

atc cgg aac ccc gcc agc ctc aaa atc gtg gcc cgg gag aat ggc ggg     3170
Ile Arg Asn Pro Ala Ser Leu Lys Ile Val Ala Arg Glu Asn Gly Gly
        880                 885                 890

gcc tca cac cct ctc ctg gac cag cgg cag cct cac tac tca gct ttt     3218
Ala Ser His Pro Leu Leu Asp Gln Arg Gln Pro His Tyr Ser Ala Phe
    895                 900                 905

ggc tct gtg ggc gag tgg ctt cgg gcc atc aaa atg gga aga tac gaa     3266
Gly Ser Val Gly Glu Trp Leu Arg Ala Ile Lys Met Gly Arg Tyr Glu
910                 915                 920                 925

gaa agt ttc gca gcc gct ggc ttt ggc tcc ttc gag ctg gtc agc cag     3314
Glu Ser Phe Ala Ala Ala Gly Phe Gly Ser Phe Glu Leu Val Ser Gln
                930                 935                 940

atc tct gct gag gac ctg ctc cga atc gga gtc act ctg gcg gga cac     3362
Ile Ser Ala Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His
            945                 950                 955

cag aag aaa atc ttg gcc agt gtc cag cac atg aag tcc cag gcc aag     3410
Gln Lys Lys Ile Leu Ala Ser Val Gln His Met Lys Ser Gln Ala Lys
        960                 965                 970

ccg gga acc ccg ggt ggg aca gga gga ccg gcc ccg cag tac tga         3455
Pro Gly Thr Pro Gly Gly Thr Gly Gly Pro Ala Pro Gln Tyr
    975                 980                 985

cctgcaggaa ctccccaccc cagggacacc gcctccccat tttccggggc agagtgggga   3515

ctcacagagg cccccagccc tgtgccccgc tggattgcac tttgagcccg tggggtgagg   3575

agttggcaat ttggagagac aggatttggg ggttctgcca taataggagg ggaaaatcac   3635

cccccagcca cctcggggaa ctccagacca agggtgaggg cgcctttccc tcaggactgg   3695

gtgtgaccag aggaaaagga agtgcccaac atctcccagc ctccccaggt gcccccctca   3755

ccttgatggg tgcgttcccg cagaccaaag agagtgtgac tcccttgcca gctccagagt   3815

gggggggctg tcccaggggg caagaagggg tgtcagggcc cagtgacaaa atcattgggg   3875

tttgtagtcc caacttgctg ctgtcaccac caaactcaat catttttttc ccttgtaaat   3935

gcccctcccc cagctgctgc cttcatattg aaggtttttg agttttgttt ttggtcttaa   3995

tttttctccc cgttcccttt ttgtttcttc gttttgtttt tctaccgtcc ttgtcataac   4055

tttgtgttgg agggaacctg tttcactatg gcctcctttg cccaagttga aacaggggcc   4115

catcatcatg tctgtttcca gaacagtgcc ttggtcatcc cacatccccg gaccccgcct   4175

gggaccccca agctgtgtcc tatgaagggg tgtggggtga ggtagtgaaa agggcggtag   4235

ttggtggtgg aacccagaaa cggacgccgg tgcttggagg ggttcttaaa ttatatttaa   4295

aaaagtaact ttttgtataa ataaaagaaa atgggacgtg tcccagctcc aggggtaaaa   4355

aaaaaaaaaa aaaa                                                     4369


<210>  20
<211>  987
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu
1               5                   10                  15


Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp
            20                  25                  30


Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu
        35                  40                  45


Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln
    50                  55                  60


Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg
65                  70                  75                  80


Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu
                85                  90                  95


Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr
            100                 105                 110


Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro
        115                 120                 125


Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu
    130                 135                 140


His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn
145                 150                 155                 160


Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu
                165                 170                 175


Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu
            180                 185                 190


Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro
        195                 200                 205


Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val
    210                 215                 220


Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg
225                 230                 235                 240


Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala
                245                 250                 255


Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Ala Cys Ala
            260                 265                 270


Gln Gly Thr Phe Lys Pro Leu Ser Gly Glu Gly Ser Cys Gln Pro Cys
        275                 280                 285


Pro Ala Asn Ser His Ser Asn Thr Ile Gly Ser Ala Val Cys Gln Cys
    290                 295                 300


Arg Val Gly Tyr Phe Arg Ala Arg Thr Asp Pro Arg Gly Ala Pro Cys
305                 310                 315                 320


Thr Thr Pro Pro Ser Ala Pro Arg Ser Val Val Ser Arg Leu Asn Gly
                325                 330                 335


Ser Ser Leu His Leu Glu Trp Ser Ala Pro Leu Glu Ser Gly Gly Arg
            340                 345                 350


Glu Asp Leu Thr Tyr Ala Leu Arg Cys Arg Glu Cys Arg Pro Gly Gly
        355                 360                 365


Ser Cys Ala Pro Cys Gly Gly Asp Leu Thr Phe Asp Pro Gly Pro Arg
    370                 375                 380


Asp Leu Val Glu Pro Trp Val Val Val Arg Gly Leu Arg Pro Asp Phe
385                 390                 395                 400


Thr Tyr Thr Phe Glu Val Thr Ala Leu Asn Gly Val Ser Ser Leu Ala
                405                 410                 415


Thr Gly Pro Val Pro Phe Glu Pro Val Asn Val Thr Thr Asp Arg Glu
            420                 425                 430


Val Pro Pro Ala Val Ser Asp Ile Arg Val Thr Arg Ser Ser Pro Ser
        435                 440                 445


Ser Leu Ser Leu Ala Trp Ala Val Pro Arg Ala Pro Ser Gly Ala Val
    450                 455                 460


Leu Asp Tyr Glu Val Lys Tyr His Glu Lys Gly Ala Glu Gly Pro Ser
465                 470                 475                 480


Ser Val Arg Phe Leu Lys Thr Ser Glu Asn Arg Ala Glu Leu Arg Gly
                485                 490                 495


Leu Lys Arg Gly Ala Ser Tyr Leu Val Gln Val Arg Ala Arg Ser Glu
            500                 505                 510


Ala Gly Tyr Gly Pro Phe Gly Gln Glu His His Ser Gln Thr Gln Leu
        515                 520                 525


Asp Glu Ser Glu Gly Trp Arg Glu Gln Leu Ala Leu Ile Ala Gly Thr
    530                 535                 540


Ala Val Val Gly Val Val Leu Val Leu Val Val Ile Val Val Ala Val
545                 550                 555                 560


Leu Cys Leu Arg Lys Gln Ser Asn Gly Arg Glu Ala Glu Tyr Ser Asp
                565                 570                 575


Lys His Gly Gln Tyr Leu Ile Gly His Gly Thr Lys Val Tyr Ile Asp
            580                 585                 590


Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys
        595                 600                 605


Glu Ile Asp Val Ser Tyr Val Lys Ile Glu Glu Val Ile Gly Ala Gly
    610                 615                 620


Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Ala Pro Gly Lys Lys
625                 630                 635                 640


Glu Ser Cys Val Ala Ile Lys Thr Leu Lys Gly Gly Tyr Thr Glu Arg
                645                 650                 655


Gln Arg Arg Glu Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Glu
            660                 665                 670


His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Asn Ser Met Pro
        675                 680                 685


Val Met Ile Leu Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ser Phe
    690                 695                 700


Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met
705                 710                 715                 720


Leu Arg Gly Ile Ala Ser Gly Met Arg Tyr Leu Ala Glu Met Ser Tyr
                725                 730                 735


Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu
            740                 745                 750


Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Glu Asn
        755                 760                 765


Ser Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile Pro Ile
    770                 775                 780


Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala
785                 790                 795                 800


Ser Asp Ala Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Phe
                805                 810                 815


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Asn Ala
            820                 825                 830


Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Pro Asp Cys Pro Thr Ser
        835                 840                 845


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Ala Arg
    850                 855                 860


Pro Arg Phe Pro Gln Val Val Ser Ala Leu Asp Lys Met Ile Arg Asn
865                 870                 875                 880


Pro Ala Ser Leu Lys Ile Val Ala Arg Glu Asn Gly Gly Ala Ser His
                885                 890                 895


Pro Leu Leu Asp Gln Arg Gln Pro His Tyr Ser Ala Phe Gly Ser Val
            900                 905                 910


Gly Glu Trp Leu Arg Ala Ile Lys Met Gly Arg Tyr Glu Glu Ser Phe
        915                 920                 925


Ala Ala Ala Gly Phe Gly Ser Phe Glu Leu Val Ser Gln Ile Ser Ala
    930                 935                 940


Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln Lys Lys
945                 950                 955                 960


Ile Leu Ala Ser Val Gln His Met Lys Ser Gln Ala Lys Pro Gly Thr
                965                 970                 975


Pro Gly Gly Thr Gly Gly Pro Ala Pro Gln Tyr
            980                 985


<210>  21
<211>  4059
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (833)..(3853)

<400>  21
ggggcgggcc gggccggctt gggaggggac gcggaggggg cgggccgggc tgcgttcgct     60

ccagccgcgg ctctacagca gcgggcggcg ggacccggga cccagcttgg cgacggcgat    120

ctcgacgcgg gcccccagga tctcccggcg ccccacctct ggagcagccc ctgccgccag    180

cgtcaggtcc accccggaat cccagggact ctcggcgccg aacggacccg ggccgggtgc    240

aacggggtcc ccggactgga gaagacgcgg gtggcaccgt gcgagctcca ggagccccgg    300

gtccactgcg aggcctcggg gggcgcagac ctgcagagac tgcggccaac gggaagaaat    360

aaagggatta tagtccaccc aattcacaga cttctgagac tcagacacga ggagagatag    420

agaaccgcca atctctagat caacaagcaa aggaggtgcc aagcctgttt gtcttcattg    480

tgacactgga gtctagatgc tgggaagtcc aagatcaggg tgccggcatg gtcagttcct    540

ggcgaagcct ctcttctagg tttcagactg ccctcttctt tgttgtgtcc tcgaatggca    600

gaaaaagggg tggctgttgg aggaagggag gagagtaaat gaagagaaag aactggaata    660

accccttgca gaaaaaaaaa aaaagggaag caagcttagc tgtacaccct gagtcttgca    720

aaagctgcag ccccacccag gagcagggtg gtggctgggg cgatggtgga cgccctgaag    780

atgtcccatg gctactgaag gggctgccca gttagggaac agagtggcgg gc atg gtg    838
                                                          Met Val
                                                          1

tgt agc cta tgg gtg ctg ctc ctg gtg tct tca gtt ctg gct ctg gaa      886
Cys Ser Leu Trp Val Leu Leu Leu Val Ser Ser Val Leu Ala Leu Glu
        5                   10                  15

gag gta ttg ctg gac acc acc gga gag aca tct gag att ggc tgg ctc      934
Glu Val Leu Leu Asp Thr Thr Gly Glu Thr Ser Glu Ile Gly Trp Leu
    20                  25                  30

acc tac cca cca ggg ggg tgg gac gag gtg agt gtt ctg gac gac cag      982
Thr Tyr Pro Pro Gly Gly Trp Asp Glu Val Ser Val Leu Asp Asp Gln
35                  40                  45                  50

cga cgc ctg act cgg acc ttt gag gca tgt cat gtg gca ggg gcc cct     1030
Arg Arg Leu Thr Arg Thr Phe Glu Ala Cys His Val Ala Gly Ala Pro
                55                  60                  65

cca ggc acc ggg cag gac aat tgg ttg cag aca cac ttt gtg gag cgg     1078
Pro Gly Thr Gly Gln Asp Asn Trp Leu Gln Thr His Phe Val Glu Arg
            70                  75                  80

cgc ggg gcc cag agg gcg cac att cga ctc cac ttc tct gtg cgg gca     1126
Arg Gly Ala Gln Arg Ala His Ile Arg Leu His Phe Ser Val Arg Ala
        85                  90                  95

tgc tcc agc ctg ggt gtg agc ggc ggc acc tgc cgg gag acc ttc acc     1174
Cys Ser Ser Leu Gly Val Ser Gly Gly Thr Cys Arg Glu Thr Phe Thr
    100                 105                 110

ctt tac tac cgt cag gct gag gag ccc gac agc cct gac agc gtt tcc     1222
Leu Tyr Tyr Arg Gln Ala Glu Glu Pro Asp Ser Pro Asp Ser Val Ser
115                 120                 125                 130

tcc tgg cac ctc aaa cgc tgg acc aag gtg gac aca att gca gca gac     1270
Ser Trp His Leu Lys Arg Trp Thr Lys Val Asp Thr Ile Ala Ala Asp
                135                 140                 145

gag agc ttt ccc tcc tcc tcc tcc tcc tcc tcc tct tct tcc tct gca     1318
Glu Ser Phe Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala
            150                 155                 160

gcg tgg gct gtg gga ccc cac ggg gct ggg cag cgg gct gga ctg caa     1366
Ala Trp Ala Val Gly Pro His Gly Ala Gly Gln Arg Ala Gly Leu Gln
        165                 170                 175

ctg aac gtc aaa gag cgg agc ttt ggg cct ctc acc caa cgc ggc ttc     1414
Leu Asn Val Lys Glu Arg Ser Phe Gly Pro Leu Thr Gln Arg Gly Phe
    180                 185                 190

tac gtg gcc ttc cag gac acg ggg gcc tgc ctg gcc ctg gtc gct gtc     1462
Tyr Val Ala Phe Gln Asp Thr Gly Ala Cys Leu Ala Leu Val Ala Val
195                 200                 205                 210

agg ctc ttc tcc tac acc tgc cct gcc gtg ctc cga tcc ttt gct tcc     1510
Arg Leu Phe Ser Tyr Thr Cys Pro Ala Val Leu Arg Ser Phe Ala Ser
                215                 220                 225

ttt cca gag acg cag gcc agt ggg gct ggg ggg gcc tcc ctg gtg gca     1558
Phe Pro Glu Thr Gln Ala Ser Gly Ala Gly Gly Ala Ser Leu Val Ala
            230                 235                 240

gct gtg ggc acc tgt gtg gct cat gca gag cca gag gag gat gga gta     1606
Ala Val Gly Thr Cys Val Ala His Ala Glu Pro Glu Glu Asp Gly Val
        245                 250                 255

ggg ggc cag gca gga ggc agc ccc ccc agg ctg cac tgc aac ggg gag     1654
Gly Gly Gln Ala Gly Gly Ser Pro Pro Arg Leu His Cys Asn Gly Glu
    260                 265                 270

ggc aag tgg atg gta gct gtc ggg ggc tgc cgc tgc cag cct gga tac     1702
Gly Lys Trp Met Val Ala Val Gly Gly Cys Arg Cys Gln Pro Gly Tyr
275                 280                 285                 290

caa cca gca cga gga gac aag gcc tgc caa gcc tgc cca cgg ggg ctc     1750
Gln Pro Ala Arg Gly Asp Lys Ala Cys Gln Ala Cys Pro Arg Gly Leu
                295                 300                 305

tat aag tct tct gct ggg aat gct ccc tgc tca cca tgc cct gcc cgc     1798
Tyr Lys Ser Ser Ala Gly Asn Ala Pro Cys Ser Pro Cys Pro Ala Arg
            310                 315                 320

agt cac gct ccc aac cca gca gcc ccc gtt tgc ccc tgc ctg gag ggc     1846
Ser His Ala Pro Asn Pro Ala Ala Pro Val Cys Pro Cys Leu Glu Gly
        325                 330                 335

ttc tac cgg gcc agt tcc gac cca cca gag gcc ccc tgc act ggt cct     1894
Phe Tyr Arg Ala Ser Ser Asp Pro Pro Glu Ala Pro Cys Thr Gly Pro
    340                 345                 350

cca tcg gct ccc cag gag ctt tgg ttt gag gtg caa ggc tca gca ctc     1942
Pro Ser Ala Pro Gln Glu Leu Trp Phe Glu Val Gln Gly Ser Ala Leu
355                 360                 365                 370

atg cta cac tgg cgc ctg cct cgg gag ctg ggg ggt cga ggg gac ctg     1990
Met Leu His Trp Arg Leu Pro Arg Glu Leu Gly Gly Arg Gly Asp Leu
                375                 380                 385

ctc ttc aat gtc gtg tgc aag gag tgt gaa ggc cgc cag gaa cct gcc     2038
Leu Phe Asn Val Val Cys Lys Glu Cys Glu Gly Arg Gln Glu Pro Ala
            390                 395                 400

agc ggt ggt ggg ggc act tgt cac cgc tgc agg gat gag gtc cac ttc     2086
Ser Gly Gly Gly Gly Thr Cys His Arg Cys Arg Asp Glu Val His Phe
        405                 410                 415

gac cct cgc cag aga ggc ctg act gag agc cga gtg tta gtg ggg gga     2134
Asp Pro Arg Gln Arg Gly Leu Thr Glu Ser Arg Val Leu Val Gly Gly
    420                 425                 430

ctc cgg gca cac gta ccc tac atc tta gag gtg cag gct gtt aat ggg     2182
Leu Arg Ala His Val Pro Tyr Ile Leu Glu Val Gln Ala Val Asn Gly
435                 440                 445                 450

gtg tct gag ctc agc cct gac cct cct cag gct gca gcc atc aat gtc     2230
Val Ser Glu Leu Ser Pro Asp Pro Pro Gln Ala Ala Ala Ile Asn Val
                455                 460                 465

agc acc agc cat gaa gtg ccc tct gct gtc cct gtg gtg cac cag gtg     2278
Ser Thr Ser His Glu Val Pro Ser Ala Val Pro Val Val His Gln Val
            470                 475                 480

agc cgg gca tcc aac agc atc acg gtg tcc tgg ccg cag ccc gac cag     2326
Ser Arg Ala Ser Asn Ser Ile Thr Val Ser Trp Pro Gln Pro Asp Gln
        485                 490                 495

acc aat ggg aac atc ctg gac tat cag ctc cgc tac tat gac cag gca     2374
Thr Asn Gly Asn Ile Leu Asp Tyr Gln Leu Arg Tyr Tyr Asp Gln Ala
    500                 505                 510

gaa gac gaa tcc cac tcc ttc acc ctg acc agc gag acc aac act gcc     2422
Glu Asp Glu Ser His Ser Phe Thr Leu Thr Ser Glu Thr Asn Thr Ala
515                 520                 525                 530

acc gtg aca cag ctg agc cct ggc cac atc tat ggt ttc cag gtg cgg     2470
Thr Val Thr Gln Leu Ser Pro Gly His Ile Tyr Gly Phe Gln Val Arg
                535                 540                 545

gcc cgg act gct gcc ggc cac ggc ccc tac ggg ggc aaa gtc tat ttc     2518
Ala Arg Thr Ala Ala Gly His Gly Pro Tyr Gly Gly Lys Val Tyr Phe
            550                 555                 560

cag aca ctt cct caa ggg gag ctg tct tcc cag ctt ccg gaa aga ctc     2566
Gln Thr Leu Pro Gln Gly Glu Leu Ser Ser Gln Leu Pro Glu Arg Leu
        565                 570                 575

tcc ttg gtg atc ggc tcc atc ctg ggg gct ttg gcc ttc ctc ctg ctg     2614
Ser Leu Val Ile Gly Ser Ile Leu Gly Ala Leu Ala Phe Leu Leu Leu
    580                 585                 590

gca gcc atc acc gtg ctg gcg gtc gtc ttc cag cgg aag cgg cgt ggg     2662
Ala Ala Ile Thr Val Leu Ala Val Val Phe Gln Arg Lys Arg Arg Gly
595                 600                 605                 610

act ggc tac acg gag cag ctg cag caa tac agc agc cca gga ctc ggg     2710
Thr Gly Tyr Thr Glu Gln Leu Gln Gln Tyr Ser Ser Pro Gly Leu Gly
                615                 620                 625

gtg aag tat tac atc gac ccc tcc acc tac gag gac ccc tgt cag gcc     2758
Val Lys Tyr Tyr Ile Asp Pro Ser Thr Tyr Glu Asp Pro Cys Gln Ala
            630                 635                 640

atc cga gaa ctt gcc cgg gaa gtc gat cct gct tat atc aag att gag     2806
Ile Arg Glu Leu Ala Arg Glu Val Asp Pro Ala Tyr Ile Lys Ile Glu
        645                 650                 655

gag gtc att ggg aca ggc tct ttt gga gaa gtg cgc cag ggc cgc ctg     2854
Glu Val Ile Gly Thr Gly Ser Phe Gly Glu Val Arg Gln Gly Arg Leu
    660                 665                 670

cag cca cgg gga cgg agg gag cag act gtg gcc atc cag gcc ctg tgg     2902
Gln Pro Arg Gly Arg Arg Glu Gln Thr Val Ala Ile Gln Ala Leu Trp
675                 680                 685                 690

gcc ggg ggc gcc gaa agc ctg cag atg acc ttc ctg ggc cgg gcc gca     2950
Ala Gly Gly Ala Glu Ser Leu Gln Met Thr Phe Leu Gly Arg Ala Ala
                695                 700                 705

gtg ctg ggt cag ttc cag cac ccc aac atc ctg cgg ctg gag ggc gtg     2998
Val Leu Gly Gln Phe Gln His Pro Asn Ile Leu Arg Leu Glu Gly Val
            710                 715                 720

gtc acc aag agc cga ccc ctc atg gtg ctg acg gag ttc atg gag ctt     3046
Val Thr Lys Ser Arg Pro Leu Met Val Leu Thr Glu Phe Met Glu Leu
        725                 730                 735

ggc ccc ctg gac agc ttc ctc agg cag cgg gag ggc cag ttc agc agc     3094
Gly Pro Leu Asp Ser Phe Leu Arg Gln Arg Glu Gly Gln Phe Ser Ser
    740                 745                 750

ctg cag ctg gtg gcc atg cag cgg gga gtg gct gct gcc atg cag tac     3142
Leu Gln Leu Val Ala Met Gln Arg Gly Val Ala Ala Ala Met Gln Tyr
755                 760                 765                 770

ctg tcc agc ttt gcc ttc gtc cat cgc tcg ctg tct gcc cac agc gtg     3190
Leu Ser Ser Phe Ala Phe Val His Arg Ser Leu Ser Ala His Ser Val
                775                 780                 785

ctg gtg aat agc cac ttg gtg tgc aag gtg gcc cgt ctt ggc cac agt     3238
Leu Val Asn Ser His Leu Val Cys Lys Val Ala Arg Leu Gly His Ser
            790                 795                 800

cct cag ggc cca agt tgt ttg ctt cgc tgg gca gcc cca gag gtc att     3286
Pro Gln Gly Pro Ser Cys Leu Leu Arg Trp Ala Ala Pro Glu Val Ile
        805                 810                 815

gca cat gga aag cat aca aca tcc agt gat gtc tgg agc ttt ggg ata     3334
Ala His Gly Lys His Thr Thr Ser Ser Asp Val Trp Ser Phe Gly Ile
    820                 825                 830

ctc atg tgg gaa gtg atg agt tat gga gaa cgg cct tac tgg gac atg     3382
Leu Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met
835                 840                 845                 850

agt gag cag gag gta cta aat gca ata gag cag gag ttc cgg ctg ccc     3430
Ser Glu Gln Glu Val Leu Asn Ala Ile Glu Gln Glu Phe Arg Leu Pro
                855                 860                 865

ccg cct cca ggc tgt cct cct gga tta cat cta ctt atg ttg gac act     3478
Pro Pro Pro Gly Cys Pro Pro Gly Leu His Leu Leu Met Leu Asp Thr
            870                 875                 880

tgg cag aag gac cgt gcc cgg cgg cct cat ttt gac cag ctg gtg gct     3526
Trp Gln Lys Asp Arg Ala Arg Arg Pro His Phe Asp Gln Leu Val Ala
        885                 890                 895

gca ttt gac aag atg atc cgc aag cca gat acc ctg cag gct ggc ggg     3574
Ala Phe Asp Lys Met Ile Arg Lys Pro Asp Thr Leu Gln Ala Gly Gly
    900                 905                 910

gac cca ggg gaa agg cct tcc cag gcc ctt ctg acc cct gtg gcc ctg     3622
Asp Pro Gly Glu Arg Pro Ser Gln Ala Leu Leu Thr Pro Val Ala Leu
915                 920                 925                 930

gac ttt cct tgt ctg gac tca ccc cag gcc tgg ctt tca gcc att gga     3670
Asp Phe Pro Cys Leu Asp Ser Pro Gln Ala Trp Leu Ser Ala Ile Gly
                935                 940                 945

ctg gag tgc tac cag gac aac ttc tcc aag ttt ggc ctc tgt acc ttc     3718
Leu Glu Cys Tyr Gln Asp Asn Phe Ser Lys Phe Gly Leu Cys Thr Phe
            950                 955                 960

agt gat gtg gct cag ctc agc cta gaa gac ctg cct gcc ctg ggc atc     3766
Ser Asp Val Ala Gln Leu Ser Leu Glu Asp Leu Pro Ala Leu Gly Ile
        965                 970                 975

acc ctg gct ggc cac cag aag aag ctg ctg cac cac atc cag ctc ctt     3814
Thr Leu Ala Gly His Gln Lys Lys Leu Leu His His Ile Gln Leu Leu
    980                 985                 990

cag caa cac ctg agg cag  cag ggc tca gtg gag  gtc tga gaatgacgat    3863
Gln Gln His Leu Arg Gln  Gln Gly Ser Val Glu  Val
995                 1000                 1005

acccgtgact cagccctgga cactggtccg agaagggaca tgtgggacgt gagccgggct   3923

ccaacagcct ctgtgagaga tgccccacac caaacccaac cctcccgatg gctgcattcc   3983

ctggtcctcc gcctctccac cagccccctc ctcattaaag ggaaagaagg gaatttgcaa   4043

aaaaaaaaaa aaaaaa                                                   4059


<210>  22
<211>  1006
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Val Cys Ser Leu Trp Val Leu Leu Leu Val Ser Ser Val Leu Ala
1               5                   10                  15


Leu Glu Glu Val Leu Leu Asp Thr Thr Gly Glu Thr Ser Glu Ile Gly
            20                  25                  30


Trp Leu Thr Tyr Pro Pro Gly Gly Trp Asp Glu Val Ser Val Leu Asp
        35                  40                  45


Asp Gln Arg Arg Leu Thr Arg Thr Phe Glu Ala Cys His Val Ala Gly
    50                  55                  60


Ala Pro Pro Gly Thr Gly Gln Asp Asn Trp Leu Gln Thr His Phe Val
65                  70                  75                  80


Glu Arg Arg Gly Ala Gln Arg Ala His Ile Arg Leu His Phe Ser Val
                85                  90                  95


Arg Ala Cys Ser Ser Leu Gly Val Ser Gly Gly Thr Cys Arg Glu Thr
            100                 105                 110


Phe Thr Leu Tyr Tyr Arg Gln Ala Glu Glu Pro Asp Ser Pro Asp Ser
        115                 120                 125


Val Ser Ser Trp His Leu Lys Arg Trp Thr Lys Val Asp Thr Ile Ala
    130                 135                 140


Ala Asp Glu Ser Phe Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
145                 150                 155                 160


Ser Ala Ala Trp Ala Val Gly Pro His Gly Ala Gly Gln Arg Ala Gly
                165                 170                 175


Leu Gln Leu Asn Val Lys Glu Arg Ser Phe Gly Pro Leu Thr Gln Arg
            180                 185                 190


Gly Phe Tyr Val Ala Phe Gln Asp Thr Gly Ala Cys Leu Ala Leu Val
        195                 200                 205


Ala Val Arg Leu Phe Ser Tyr Thr Cys Pro Ala Val Leu Arg Ser Phe
    210                 215                 220


Ala Ser Phe Pro Glu Thr Gln Ala Ser Gly Ala Gly Gly Ala Ser Leu
225                 230                 235                 240


Val Ala Ala Val Gly Thr Cys Val Ala His Ala Glu Pro Glu Glu Asp
                245                 250                 255


Gly Val Gly Gly Gln Ala Gly Gly Ser Pro Pro Arg Leu His Cys Asn
            260                 265                 270


Gly Glu Gly Lys Trp Met Val Ala Val Gly Gly Cys Arg Cys Gln Pro
        275                 280                 285


Gly Tyr Gln Pro Ala Arg Gly Asp Lys Ala Cys Gln Ala Cys Pro Arg
    290                 295                 300


Gly Leu Tyr Lys Ser Ser Ala Gly Asn Ala Pro Cys Ser Pro Cys Pro
305                 310                 315                 320


Ala Arg Ser His Ala Pro Asn Pro Ala Ala Pro Val Cys Pro Cys Leu
                325                 330                 335


Glu Gly Phe Tyr Arg Ala Ser Ser Asp Pro Pro Glu Ala Pro Cys Thr
            340                 345                 350


Gly Pro Pro Ser Ala Pro Gln Glu Leu Trp Phe Glu Val Gln Gly Ser
        355                 360                 365


Ala Leu Met Leu His Trp Arg Leu Pro Arg Glu Leu Gly Gly Arg Gly
    370                 375                 380


Asp Leu Leu Phe Asn Val Val Cys Lys Glu Cys Glu Gly Arg Gln Glu
385                 390                 395                 400


Pro Ala Ser Gly Gly Gly Gly Thr Cys His Arg Cys Arg Asp Glu Val
                405                 410                 415


His Phe Asp Pro Arg Gln Arg Gly Leu Thr Glu Ser Arg Val Leu Val
            420                 425                 430


Gly Gly Leu Arg Ala His Val Pro Tyr Ile Leu Glu Val Gln Ala Val
        435                 440                 445


Asn Gly Val Ser Glu Leu Ser Pro Asp Pro Pro Gln Ala Ala Ala Ile
    450                 455                 460


Asn Val Ser Thr Ser His Glu Val Pro Ser Ala Val Pro Val Val His
465                 470                 475                 480


Gln Val Ser Arg Ala Ser Asn Ser Ile Thr Val Ser Trp Pro Gln Pro
                485                 490                 495


Asp Gln Thr Asn Gly Asn Ile Leu Asp Tyr Gln Leu Arg Tyr Tyr Asp
            500                 505                 510


Gln Ala Glu Asp Glu Ser His Ser Phe Thr Leu Thr Ser Glu Thr Asn
        515                 520                 525


Thr Ala Thr Val Thr Gln Leu Ser Pro Gly His Ile Tyr Gly Phe Gln
    530                 535                 540


Val Arg Ala Arg Thr Ala Ala Gly His Gly Pro Tyr Gly Gly Lys Val
545                 550                 555                 560


Tyr Phe Gln Thr Leu Pro Gln Gly Glu Leu Ser Ser Gln Leu Pro Glu
                565                 570                 575


Arg Leu Ser Leu Val Ile Gly Ser Ile Leu Gly Ala Leu Ala Phe Leu
            580                 585                 590


Leu Leu Ala Ala Ile Thr Val Leu Ala Val Val Phe Gln Arg Lys Arg
        595                 600                 605


Arg Gly Thr Gly Tyr Thr Glu Gln Leu Gln Gln Tyr Ser Ser Pro Gly
    610                 615                 620


Leu Gly Val Lys Tyr Tyr Ile Asp Pro Ser Thr Tyr Glu Asp Pro Cys
625                 630                 635                 640


Gln Ala Ile Arg Glu Leu Ala Arg Glu Val Asp Pro Ala Tyr Ile Lys
                645                 650                 655


Ile Glu Glu Val Ile Gly Thr Gly Ser Phe Gly Glu Val Arg Gln Gly
            660                 665                 670


Arg Leu Gln Pro Arg Gly Arg Arg Glu Gln Thr Val Ala Ile Gln Ala
        675                 680                 685


Leu Trp Ala Gly Gly Ala Glu Ser Leu Gln Met Thr Phe Leu Gly Arg
    690                 695                 700


Ala Ala Val Leu Gly Gln Phe Gln His Pro Asn Ile Leu Arg Leu Glu
705                 710                 715                 720


Gly Val Val Thr Lys Ser Arg Pro Leu Met Val Leu Thr Glu Phe Met
                725                 730                 735


Glu Leu Gly Pro Leu Asp Ser Phe Leu Arg Gln Arg Glu Gly Gln Phe
            740                 745                 750


Ser Ser Leu Gln Leu Val Ala Met Gln Arg Gly Val Ala Ala Ala Met
        755                 760                 765


Gln Tyr Leu Ser Ser Phe Ala Phe Val His Arg Ser Leu Ser Ala His
    770                 775                 780


Ser Val Leu Val Asn Ser His Leu Val Cys Lys Val Ala Arg Leu Gly
785                 790                 795                 800


His Ser Pro Gln Gly Pro Ser Cys Leu Leu Arg Trp Ala Ala Pro Glu
                805                 810                 815


Val Ile Ala His Gly Lys His Thr Thr Ser Ser Asp Val Trp Ser Phe
            820                 825                 830


Gly Ile Leu Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp
        835                 840                 845


Asp Met Ser Glu Gln Glu Val Leu Asn Ala Ile Glu Gln Glu Phe Arg
    850                 855                 860


Leu Pro Pro Pro Pro Gly Cys Pro Pro Gly Leu His Leu Leu Met Leu
865                 870                 875                 880


Asp Thr Trp Gln Lys Asp Arg Ala Arg Arg Pro His Phe Asp Gln Leu
                885                 890                 895


Val Ala Ala Phe Asp Lys Met Ile Arg Lys Pro Asp Thr Leu Gln Ala
            900                 905                 910


Gly Gly Asp Pro Gly Glu Arg Pro Ser Gln Ala Leu Leu Thr Pro Val
        915                 920                 925


Ala Leu Asp Phe Pro Cys Leu Asp Ser Pro Gln Ala Trp Leu Ser Ala
    930                 935                 940


Ile Gly Leu Glu Cys Tyr Gln Asp Asn Phe Ser Lys Phe Gly Leu Cys
945                 950                 955                 960


Thr Phe Ser Asp Val Ala Gln Leu Ser Leu Glu Asp Leu Pro Ala Leu
                965                 970                 975


Gly Ile Thr Leu Ala Gly His Gln Lys Lys Leu Leu His His Ile Gln
            980                 985                 990


Leu Leu Gln Gln His Leu Arg Gln  Gln Gly Ser Val Glu  Val
        995                 1000                 1005


<210>  23
<211>  5084
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (22)..(2952)

<400>  23
gatcccatcg cagctaccgc g atg aga ggc gct cgc ggc gcc tgg gat ttt       51
                        Met Arg Gly Ala Arg Gly Ala Trp Asp Phe
                        1               5                   10

ctc tgc gtt ctg ctc cta ctg ctt cgc gtc cag aca ggc tct tct caa       99
Leu Cys Val Leu Leu Leu Leu Leu Arg Val Gln Thr Gly Ser Ser Gln
                15                  20                  25

cca tct gtg agt cca ggg gaa ccg tct cca cca tcc atc cat cca gga      147
Pro Ser Val Ser Pro Gly Glu Pro Ser Pro Pro Ser Ile His Pro Gly
            30                  35                  40

aaa tca gac tta ata gtc cgc gtg ggc gac gag att agg ctg tta tgc      195
Lys Ser Asp Leu Ile Val Arg Val Gly Asp Glu Ile Arg Leu Leu Cys
        45                  50                  55

act gat ccg ggc ttt gtc aaa tgg act ttt gag atc ctg gat gaa acg      243
Thr Asp Pro Gly Phe Val Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr
    60                  65                  70

aat gag aat aag cag aat gaa tgg atc acg gaa aag gca gaa gcc acc      291
Asn Glu Asn Lys Gln Asn Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr
75                  80                  85                  90

aac acc ggc aaa tac acg tgc acc aac aaa cac ggc tta agc aat tcc      339
Asn Thr Gly Lys Tyr Thr Cys Thr Asn Lys His Gly Leu Ser Asn Ser
                95                  100                 105

att tat gtg ttt gtt aga gat cct gcc aag ctt ttc ctt gtt gac cgc      387
Ile Tyr Val Phe Val Arg Asp Pro Ala Lys Leu Phe Leu Val Asp Arg
            110                 115                 120

tcc ttg tat ggg aaa gaa gac aac gac acg ctg gtc cgc tgt cct ctc      435
Ser Leu Tyr Gly Lys Glu Asp Asn Asp Thr Leu Val Arg Cys Pro Leu
        125                 130                 135

aca gac cca gaa gtg acc aat tat tcc ctc aag ggg tgc cag ggg aag      483
Thr Asp Pro Glu Val Thr Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys
    140                 145                 150

cct ctt ccc aag gac ttg agg ttt att cct gac ccc aag gcg ggc atc      531
Pro Leu Pro Lys Asp Leu Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile
155                 160                 165                 170

atg atc aaa agt gtg aaa cgc gcc tac cat cgg ctc tgt ctg cat tgt      579
Met Ile Lys Ser Val Lys Arg Ala Tyr His Arg Leu Cys Leu His Cys
                175                 180                 185

tct gtg gac cag gag ggc aag tca gtg ctg tcg gaa aaa ttc atc ctg      627
Ser Val Asp Gln Glu Gly Lys Ser Val Leu Ser Glu Lys Phe Ile Leu
            190                 195                 200

aaa gtg agg cca gcc ttc aaa gct gtg cct gtt gtg tct gtg tcc aaa      675
Lys Val Arg Pro Ala Phe Lys Ala Val Pro Val Val Ser Val Ser Lys
        205                 210                 215

gca agc tat ctt ctt agg gaa ggg gaa gaa ttc aca gtg acg tgc aca      723
Ala Ser Tyr Leu Leu Arg Glu Gly Glu Glu Phe Thr Val Thr Cys Thr
    220                 225                 230

ata aaa gat gtg tct agt tct gtg tac tca acg tgg aaa aga gaa aac      771
Ile Lys Asp Val Ser Ser Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn
235                 240                 245                 250

agt cag act aaa cta cag gag aaa tat aat agc tgg cat cac ggt gac      819
Ser Gln Thr Lys Leu Gln Glu Lys Tyr Asn Ser Trp His His Gly Asp
                255                 260                 265

ttc aat tat gaa cgt cag gca acg ttg act atc agt tca gcg aga gtt      867
Phe Asn Tyr Glu Arg Gln Ala Thr Leu Thr Ile Ser Ser Ala Arg Val
            270                 275                 280

aat gat tct gga gtg ttc atg tgt tat gcc aat aat act ttt gga tca      915
Asn Asp Ser Gly Val Phe Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser
        285                 290                 295

gca aat gtc aca aca acc ttg gaa gta gta gat aaa gga ttc att aat      963
Ala Asn Val Thr Thr Thr Leu Glu Val Val Asp Lys Gly Phe Ile Asn
    300                 305                 310

atc ttc ccc atg ata aac act aca gta ttt gta aac gat gga gaa aat     1011
Ile Phe Pro Met Ile Asn Thr Thr Val Phe Val Asn Asp Gly Glu Asn
315                 320                 325                 330

gta gat ttg att gtt gaa tat gaa gca ttc ccc aaa cct gaa cac cag     1059
Val Asp Leu Ile Val Glu Tyr Glu Ala Phe Pro Lys Pro Glu His Gln
                335                 340                 345

cag tgg atc tat atg aac aga acc ttc act gat aaa tgg gaa gat tat     1107
Gln Trp Ile Tyr Met Asn Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr
            350                 355                 360

ccc aag tct gag aat gaa agt aat atc aga tac gta agt gaa ctt cat     1155
Pro Lys Ser Glu Asn Glu Ser Asn Ile Arg Tyr Val Ser Glu Leu His
        365                 370                 375

cta acg aga tta aaa ggc acc gaa gga ggc act tac aca ttc cta gtg     1203
Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val
    380                 385                 390

tcc aat tct gac gtc aat gct gcc ata gca ttt aat gtt tat gtg aat     1251
Ser Asn Ser Asp Val Asn Ala Ala Ile Ala Phe Asn Val Tyr Val Asn
395                 400                 405                 410

aca aaa cca gaa atc ctg act tac gac agg ctc gtg aat ggc atg ctc     1299
Thr Lys Pro Glu Ile Leu Thr Tyr Asp Arg Leu Val Asn Gly Met Leu
                415                 420                 425

caa tgt gtg gca gca gga ttc cca gag ccc aca ata gat tgg tat ttt     1347
Gln Cys Val Ala Ala Gly Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe
            430                 435                 440

tgt cca gga act gag cag aga tgc tct gct tct gta ctg cca gtg gat     1395
Cys Pro Gly Thr Glu Gln Arg Cys Ser Ala Ser Val Leu Pro Val Asp
        445                 450                 455

gtg cag aca cta aac tca tct ggg cca ccg ttt gga aag cta gtg gtt     1443
Val Gln Thr Leu Asn Ser Ser Gly Pro Pro Phe Gly Lys Leu Val Val
    460                 465                 470

cag agt tct ata gat tct agt gca ttc aag cac aat ggc acg gtt gaa     1491
Gln Ser Ser Ile Asp Ser Ser Ala Phe Lys His Asn Gly Thr Val Glu
475                 480                 485                 490

tgt aag gct tac aac gat gtg ggc aag act tct gcc tat ttt aac ttt     1539
Cys Lys Ala Tyr Asn Asp Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe
                495                 500                 505

gca ttt aaa ggt aac aac aaa gag caa atc cat ccc cac acc ctg ttc     1587
Ala Phe Lys Gly Asn Asn Lys Glu Gln Ile His Pro His Thr Leu Phe
            510                 515                 520

act cct ttg ctg att ggt ttc gta atc gta gct ggc atg atg tgc att     1635
Thr Pro Leu Leu Ile Gly Phe Val Ile Val Ala Gly Met Met Cys Ile
        525                 530                 535

att gtg atg att ctg acc tac aaa tat tta cag aaa ccc atg tat gaa     1683
Ile Val Met Ile Leu Thr Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu
    540                 545                 550

gta cag tgg aag gtt gtt gag gag ata aat gga aac aat tat gtt tac     1731
Val Gln Trp Lys Val Val Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr
555                 560                 565                 570

ata gac cca aca caa ctt cct tat gat cac aaa tgg gag ttt ccc aga     1779
Ile Asp Pro Thr Gln Leu Pro Tyr Asp His Lys Trp Glu Phe Pro Arg
                575                 580                 585

aac agg ctg agt ttt ggg aaa acc ctg ggt gct gga gct ttc ggg aag     1827
Asn Arg Leu Ser Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys
            590                 595                 600

gtt gtt gag gca act gct tat ggc tta att aag tca gat gcg gcc atg     1875
Val Val Glu Ala Thr Ala Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met
        605                 610                 615

act gtc gct gta aag atg ctc aag ccg agt gcc cat ttg aca gaa cgg     1923
Thr Val Ala Val Lys Met Leu Lys Pro Ser Ala His Leu Thr Glu Arg
    620                 625                 630

gaa gcc ctc atg tct gaa ctc aaa gtc ctg agt tac ctt ggt aat cac     1971
Glu Ala Leu Met Ser Glu Leu Lys Val Leu Ser Tyr Leu Gly Asn His
635                 640                 645                 650

atg aat att gtg aat cta ctt gga gcc tgc acc att gga ggg ccc acc     2019
Met Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr
                655                 660                 665

ctg gtc att aca gaa tat tgt tgc tat ggt gat ctt ttg aat ttt ttg     2067
Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu
            670                 675                 680

aga aga aaa cgt gat tca ttt att tgt tca aag cag gaa gat cat gca     2115
Arg Arg Lys Arg Asp Ser Phe Ile Cys Ser Lys Gln Glu Asp His Ala
        685                 690                 695

gaa gct gca ctt tat aag aat ctt ctg cat tca aag gag tct tcc tgc     2163
Glu Ala Ala Leu Tyr Lys Asn Leu Leu His Ser Lys Glu Ser Ser Cys
    700                 705                 710

agc gat agt act aat gag tac atg gac atg aaa cct gga gtt tct tat     2211
Ser Asp Ser Thr Asn Glu Tyr Met Asp Met Lys Pro Gly Val Ser Tyr
715                 720                 725                 730

gtt gtc cca acc aag gcc gac aaa agg aga tct gtg aga ata ggc tca     2259
Val Val Pro Thr Lys Ala Asp Lys Arg Arg Ser Val Arg Ile Gly Ser
                735                 740                 745

tac ata gaa aga gat gtg act ccc gcc atc atg gag gat gac gag ttg     2307
Tyr Ile Glu Arg Asp Val Thr Pro Ala Ile Met Glu Asp Asp Glu Leu
            750                 755                 760

gcc cta gac tta gaa gac ttg ctg agc ttt tct tac cag gtg gca aag     2355
Ala Leu Asp Leu Glu Asp Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys
        765                 770                 775

ggc atg gct ttc ctc gcc tcc aag aat tgt att cac aga gac ttg gca     2403
Gly Met Ala Phe Leu Ala Ser Lys Asn Cys Ile His Arg Asp Leu Ala
    780                 785                 790

gcc aga aat atc ctc ctt act cat ggt cgg atc aca aag att tgt gat     2451
Ala Arg Asn Ile Leu Leu Thr His Gly Arg Ile Thr Lys Ile Cys Asp
795                 800                 805                 810

ttt ggt cta gcc aga gac atc aag aat gat tct aat tat gtg gtt aaa     2499
Phe Gly Leu Ala Arg Asp Ile Lys Asn Asp Ser Asn Tyr Val Val Lys
                815                 820                 825

gga aac gct cga cta cct gtg aag tgg atg gca cct gaa agc att ttc     2547
Gly Asn Ala Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe
            830                 835                 840

aac tgt gta tac acg ttt gaa agt gac gtc tgg tcc tat ggg att ttt     2595
Asn Cys Val Tyr Thr Phe Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe
        845                 850                 855

ctt tgg gag ctg ttc tct tta gga agc agc ccc tat cct gga atg ccg     2643
Leu Trp Glu Leu Phe Ser Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro
    860                 865                 870

gtc gat tct aag ttc tac aag atg atc aag gaa ggc ttc cgg atg ctc     2691
Val Asp Ser Lys Phe Tyr Lys Met Ile Lys Glu Gly Phe Arg Met Leu
875                 880                 885                 890

agc cct gaa cac gca cct gct gaa atg tat gac ata atg aag act tgc     2739
Ser Pro Glu His Ala Pro Ala Glu Met Tyr Asp Ile Met Lys Thr Cys
                895                 900                 905

tgg gat gca gat ccc cta aaa aga cca aca ttc aag caa att gtt cag     2787
Trp Asp Ala Asp Pro Leu Lys Arg Pro Thr Phe Lys Gln Ile Val Gln
            910                 915                 920

cta att gag aag cag att tca gag agc acc aat cat att tac tcc aac     2835
Leu Ile Glu Lys Gln Ile Ser Glu Ser Thr Asn His Ile Tyr Ser Asn
        925                 930                 935

tta gca aac tgc agc ccc aac cga cag aag ccc gtg gta gac cat tct     2883
Leu Ala Asn Cys Ser Pro Asn Arg Gln Lys Pro Val Val Asp His Ser
    940                 945                 950

gtg cgg atc aat tct gtc ggc agc acc gct tcc tcc tcc cag cct ctg     2931
Val Arg Ile Asn Ser Val Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu
955                 960                 965                 970

ctt gtg cac gac gat gtc tga gcagaatcag tgtttgggtc acccctccag        2982
Leu Val His Asp Asp Val
                975

gaatgatctc ttcttttggc ttccatgatg gttattttct tttctttcaa cttgcatcca   3042

actccaggat agtgggcacc ccactgcaat cctgtctttc tgagcacact ttagtggccg   3102

atgatttttg tcatcagcca ccatcctatt gcaaaggttc caactgtata tattcccaat   3162

agcaacgtag cttctaccat gaacagaaaa cattctgatt tggaaaaaga gagggaggta   3222

tggactgggg gccagagtcc tttccaaggc ttctccaatt ctgcccaaaa atatggttga   3282

tagtttacct gaataaatgg tagtaatcac agttggcctt cagaaccatc catagtagta   3342

tgatgataca agattagaag ctgaaaacct aagtccttta tgtggaaaac agaacatcat   3402

tagaacaaag gacagagtat gaacacctgg gcttaagaaa tctagtattt catgctggga   3462

atgagacata ggccatgaaa aaaatgatcc ccaagtgtga acaaaagatg ctcttctgtg   3522

gaccactgca tgagctttta tactaccgac ctggttttta aatagagttt gctattagag   3582

cattgaattg gagagaaggc ctccctagcc agcacttgta tatacgcatc tataaattgt   3642

ccgtgttcat acatttgagg ggaaaacacc ataaggtttc gtttctgtat acaaccctgg   3702

cattatgtcc actgtgtata gaagtagatt aagagccata taagtttgaa ggaaacagtt   3762

aataccattt tttaaggaaa caatataacc acaaagcaca gtttgaacaa aatctcctct   3822

tttagctgat gaacttattc tgtagattct gtggaacaag cctatcagct tcagaatggc   3882

attgtactca atggatttga tgctgtttga caaagttact gattcactgc atggctccca   3942

caggagtggg aaaacactgc catcttagtt tggattctta tgtagcagga aataaagtat   4002

aggtttagcc tccttcgcag gcatgtcctg gacaccgggc cagtatctat atatgtgtat   4062

gtacgtttgt atgtgtgtag acaaatattt ggaggggtat ttttgccctg agtccaagag   4122

ggtcctttag tacctgaaaa gtaacttggc tttcattatt agtactgctc ttgtttcttt   4182

tcacatagct gtctagagta gcttaccaga agcttccata gtggtgcaga ggaagtggaa   4242

ggcatcagtc cctatgtatt tgcagttcac ctgcacttaa ggcactctgt tatttagact   4302

catcttactg tacctgttcc ttagaccttc cataatgcta ctgtctcact gaaacattta   4362

aattttaccc tttagactgt agcctggata ttattcttgt agtttacctc tttaaaaaca   4422

aaacaaaaca aaacaaaaaa ctccccttcc tcactgccca atataaaagg caaatgtgta   4482

catggcagag tttgtgtgtt gtcttgaaag attcaggtat gttgccttta tggtttcccc   4542

cttctacatt tcttagacta catttagaga actgtggccg ttatctggaa gtaaccattt   4602

gcactggagt tctatgctct cgcacctttc caaagttaac agattttggg gttgtgttgt   4662

cacccaagag attgttgttt gccatacttt gtctgaaaaa ttcctttgtg tttctattga   4722

cttcaatgat agtaagaaaa gtggttgtta gttatagatg tctaggtact tcaggggcac   4782

ttcattgaga gttttgtctt gccatacttt gtctgaaaaa ttcctttgtg tttctattga   4842

cttcaatgat agtaagaaaa gtggttgtta gttatagatg tctaggtact tcaggggcac   4902

ttcattgaga gttttgtcaa tgtcttttga atattcccaa gcccatgagt ccttgaaaat   4962

attttttata tatacagtaa ctttatgtgt aaatacataa gcggcgtaag tttaaaggat   5022

gttggtgttc cacgtgtttt attcctgtat gttgtccaat tgttgacagt tctgaagaat   5082

tc                                                                  5084


<210>  24
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu
1               5                   10                  15


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly
            20                  25                  30


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val
        35                  40                  45


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val
    50                  55                  60


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn
65                  70                  75                  80


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr
                85                  90                  95


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg
            100                 105                 110


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu
        115                 120                 125


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr
    130                 135                 140


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu
145                 150                 155                 160


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys
                165                 170                 175


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly
            180                 185                 190


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe
        195                 200                 205


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg
    210                 215                 220


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser
225                 230                 235                 240


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln
                245                 250                 255


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln
            260                 265                 270


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe
        275                 280                 285


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr
    290                 295                 300


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn
305                 310                 315                 320


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu
                325                 330                 335


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn
            340                 345                 350


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu
        355                 360                 365


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly
    370                 375                 380


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn
385                 390                 395                 400


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu
                405                 410                 415


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly
            420                 425                 430


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln
        435                 440                 445


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser
    450                 455                 460


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser
465                 470                 475                 480


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp
                485                 490                 495


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn
            500                 505                 510


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly
        515                 520                 525


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr
    530                 535                 540


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val
545                 550                 555                 560


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu
                565                 570                 575


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly
            580                 585                 590


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala
        595                 600                 605


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met
    610                 615                 620


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu
625                 630                 635                 640


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu
                645                 650                 655


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr
            660                 665                 670


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser
        675                 680                 685


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys
    690                 695                 700


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu
705                 710                 715                 720


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala
                725                 730                 735


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val
            740                 745                 750


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp
        755                 760                 765


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala
    770                 775                 780


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu
785                 790                 795                 800


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp
                805                 810                 815


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro
            820                 825                 830


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe
        835                 840                 845


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser
    850                 855                 860


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr
865                 870                 875                 880


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro
                885                 890                 895


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu
            900                 905                 910


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile
        915                 920                 925


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro
    930                 935                 940


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val
945                 950                 955                 960


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val
                965                 970                 975


<210>  25
<211>  6222
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Inventor: MIYAKE, Masato; FUJITA, Yoshiji

<220>
<221>  CDS
<222>  (908)..(5770)

<400>  25
gggggcggca gcggtggtag cagctggtac ctcccgccgc ctctgttcgg agggtcgcgg     60

ggcaccgagg tgctttccgg ccgccctctg gtcggccacc caaagccgcg ggcgctgatg    120

atgggtgagg agggggcggc aagatttcgg gcgcccctgc cctgaacgcc ctcagctgct    180

gccgccgggg ccgctccagt gcctgcgaac tctgaggagc cgaggcgccg gtgagagcaa    240

ggacgctgca aacttgcgca gcgcgggggc tgggattcac gcccagaagt tcagcaggca    300

gacagtccga agccttcccg cagcggagag atagcttgag ggtgcgcaag acggcagcct    360

ccgccctcgg ttcccgccca gaccgggcag aagagcttgg aggagccaaa aggaacgcaa    420

aaggcggcca ggacagcgtg cagcagctgg gagccgccgt tctcagcctt aaaagttgca    480

gagattggag gctgccccga gaggggacag accccagctc cgactgcggg gggcaggaga    540

ggacggtacc caactgccac ctcccttcaa ccatagtagt tcctctgtac cgagcgcagc    600

gagctacaga cgggggcgcg gcactcggcg cggagagcgg gaggctcaag gtcccagcca    660

gtgagcccag tgtgcttgag tgtctctgga ctcgcccctg agcttccagg tctgtttcat    720

ttagactcct gctcgcctcc gtgcagttgg gggaaagcaa gagacttgcg cgcacgcaca    780

gtcctctgga gatcaggtgg aaggagccgc tgggtaccaa ggactgttca gagcctcttc    840

ccatctcggg gagagcgaag ggtgaggctg ggcccggaga gcagtgtaaa cggcctcctc    900

cggcggg atg gga gcc atc ggg ctc ctg tgg ctc ctg ccg ctg ctg ctt      949
        Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu
        1               5                   10

tcc acg gca gct gtg ggc tcc ggg atg ggg acc ggc cag cgc gcg ggc      997
Ser Thr Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly
15                  20                  25                  30

tcc cca gct gcg ggg ccg ccg ctg cag ccc cgg gag cca ctc agc tac     1045
Ser Pro Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr
                35                  40                  45

tcg cgc ctg cag agg aag agt ctg gca gtt gac ttc gtg gtg ccc tcg     1093
Ser Arg Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser
            50                  55                  60

ctc ttc cgt gtc tac gcc cgg gac cta ctg ctg cca cca tcc tcc tcg     1141
Leu Phe Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser
        65                  70                  75

gag ctg aag gct ggc agg ccc gag gcc cgc ggc tcg cta gct ctg gac     1189
Glu Leu Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp
    80                  85                  90

tgc gcc ccg ctg ctc agg ttg ctg ggg ccg gcg ccg ggg gtc tcc tgg     1237
Cys Ala Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp
95                  100                 105                 110

acc gcc ggt tca cca gcc ccg gca gag gcc cgg acg ctg tcc agg gtg     1285
Thr Ala Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val
                115                 120                 125

ctg aag ggc ggc tcc gtg cgc aag ctc cgg cgt gcc aag cag ttg gtg     1333
Leu Lys Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val
            130                 135                 140

ctg gag ctg ggc gag gag gcg atc ttg gag ggt tgc gtc ggg ccc ccc     1381
Leu Glu Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro
        145                 150                 155

ggg gag gcg gct gtg ggg ctg ctc cag ttc aat ctc agc gag ctg ttc     1429
Gly Glu Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe
    160                 165                 170

agt tgg tgg att cgc caa ggc gaa ggg cga ctg agg atc cgc ctg atg     1477
Ser Trp Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met
175                 180                 185                 190

ccc gag aag aag gcg tcg gaa gtg ggc aga gag gga agg ctg tcc gcg     1525
Pro Glu Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala
                195                 200                 205

gca att cgc gcc tcc cag ccc cgc ctt ctc ttc cag atc ttc ggg act     1573
Ala Ile Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr
            210                 215                 220

ggt cat agc tcc ttg gaa tca cca aca aac atg cct tct cct tct cct     1621
Gly His Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro
        225                 230                 235

gat tat ttt aca tgg aat ctc acc tgg ata atg aaa gac tcc ttc cct     1669
Asp Tyr Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro
    240                 245                 250

ttc ctg tct cat cgc agc cga tat ggt ctg gag tgc agc ttt gac ttc     1717
Phe Leu Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe
255                 260                 265                 270

ccc tgt gag ctg gag tat tcc cct cca ctg cat gac ctc agg aac cag     1765
Pro Cys Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln
                275                 280                 285

agc tgg tcc tgg cgc cgc atc ccc tcc gag gag gcc tcc cag atg gac     1813
Ser Trp Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp
            290                 295                 300

ttg ctg gat ggg cct ggg gca gag cgt tct aag gag atg ccc aga ggc     1861
Leu Leu Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly
        305                 310                 315

tcc ttt ctc ctt ctc aac acc tca gct gac tcc aag cac acc atc ctg     1909
Ser Phe Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu
    320                 325                 330

agt ccg tgg atg agg agc agc agt gag cac tgc aca ctg gcc gtc tcg     1957
Ser Pro Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser
335                 340                 345                 350

gtg cac agg cac ctg cag ccc tct gga agg tac att gcc cag ctg ctg     2005
Val His Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu
                355                 360                 365

ccc cac aac gag gct gca aga gag atc ctc ctg atg ccc act cca ggg     2053
Pro His Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly
            370                 375                 380

aag cat ggt tgg aca gtg ctc cag gga aga atc ggg cgt cca gac aac     2101
Lys His Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn
        385                 390                 395

cca ttt cga gtg gcc ctg gaa tac atc tcc agt gga aac cgc agc ttg     2149
Pro Phe Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu
    400                 405                 410

tct gca gtg gac ttc ttt gcc ctg aag aac tgc agt gaa gga aca tcc     2197
Ser Ala Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser
415                 420                 425                 430

cca ggc tcc aag atg gcc ctg cag agc tcc ttc act tgt tgg aat ggg     2245
Pro Gly Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly
                435                 440                 445

aca gtc ctc cag ctt ggg cag gcc tgt gac ttc cac cag gac tgt gcc     2293
Thr Val Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala
            450                 455                 460

cag gga gaa gat gag agc cag atg tgc cgg aaa ctg cct gtg ggt ttt     2341
Gln Gly Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe
        465                 470                 475

tac tgc aac ttt gaa gat ggc ttc tgt ggc tgg acc caa ggc aca ctg     2389
Tyr Cys Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu
    480                 485                 490

tca ccc cac act cct caa tgg cag gtc agg acc cta aag gat gcc cgg     2437
Ser Pro His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg
495                 500                 505                 510

ttc cag gac cac caa gac cat gct cta ttg ctc agt acc act gat gtc     2485
Phe Gln Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val
                515                 520                 525

ccc gct tct gaa agt gct aca gtg acc agt gct acg ttt cct gca ccg     2533
Pro Ala Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro
            530                 535                 540

atc aag agc tct cca tgt gag ctc cga atg tcc tgg ctc att cgt gga     2581
Ile Lys Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly
        545                 550                 555

gtc ttg agg gga aac gtg tcc ttg gtg cta gtg gag aac aaa acc ggg     2629
Val Leu Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly
    560                 565                 570

aag gag caa ggc agg atg gtc tgg cat gtc gcc gcc tat gaa ggc ttg     2677
Lys Glu Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu
575                 580                 585                 590

agc ctg tgg cag tgg atg gtg ttg cct ctc ctc gat gtg tct gac agg     2725
Ser Leu Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg
                595                 600                 605

ttc tgg ctg cag atg gtc gca tgg tgg gga caa gga tcc aga gcc atc     2773
Phe Trp Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile
            610                 615                 620

gtg gct ttt gac aat atc tcc atc agc ctg gac tgc tac ctc acc att     2821
Val Ala Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile
        625                 630                 635

agc gga gag gac aag atc ctg cag aat aca gca ccc aaa tca aga aac     2869
Ser Gly Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn
    640                 645                 650

ctg ttt gag aga aac cca aac aag gag ctg aaa ccc ggg gaa aat tca     2917
Leu Phe Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser
655                 660                 665                 670

cca aga cag acc ccc atc ttt gac cct aca gtt cat tgg ctg ttc acc     2965
Pro Arg Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr
                675                 680                 685

aca tgt ggg gcc agc ggg ccc cat ggc ccc acc cag gca cag tgc aac     3013
Thr Cys Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn
            690                 695                 700

aac gcc tac cag aac tcc aac ctg agc gtg gag gtg ggg agc gag ggc     3061
Asn Ala Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly
        705                 710                 715

ccc ctg aaa ggc atc cag atc tgg aag gtg cca gcc acc gac acc tac     3109
Pro Leu Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr
    720                 725                 730

agc atc tcg ggc tac gga gct gct ggc ggg aaa ggc ggg aag aac acc     3157
Ser Ile Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr
735                 740                 745                 750

atg atg cgg tcc cac ggc gtg tct gtg ctg ggc atc ttc aac ctg gag     3205
Met Met Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu
                755                 760                 765

aag gat gac atg ctg tac atc ctg gtt ggg cag cag gga gag gac gcc     3253
Lys Asp Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala
            770                 775                 780

tgc ccc agt aca aac cag tta atc cag aaa gtc tgc att gga gag aac     3301
Cys Pro Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn
        785                 790                 795

aat gtg ata gaa gaa gaa atc cgt gtg aac aga agc gtg cat gag tgg     3349
Asn Val Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp
    800                 805                 810

gca gga ggc gga gga gga ggg ggt gga gcc acc tac gta ttt aag atg     3397
Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met
815                 820                 825                 830

aag gat gga gtg ccg gtg ccc ctg atc att gca gcc gga ggt ggt ggc     3445
Lys Asp Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly
                835                 840                 845

agg gcc tac ggg gcc aag aca gac acg ttc cac cca gag aga ctg gag     3493
Arg Ala Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu
            850                 855                 860

aat aac tcc tcg gtt cta ggg cta aac ggc aat tcc gga gcc gca ggt     3541
Asn Asn Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly
        865                 870                 875

ggt gga ggt ggc tgg aat gat aac act tcc ttg ctc tgg gcc gga aaa     3589
Gly Gly Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys
    880                 885                 890

tct ttg cag gag ggt gcc acc gga gga cat tcc tgc ccc cag gcc atg     3637
Ser Leu Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met
895                 900                 905                 910

aag aag tgg ggg tgg gag aca aga ggg ggt ttc gga ggg ggt gga ggg     3685
Lys Lys Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly
                915                 920                 925

ggg tgc tcc tca ggt gga gga ggc gga gga tat ata ggc ggc aat gca     3733
Gly Cys Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala
            930                 935                 940

gcc tca aac aat gac ccc gaa atg gat ggg gaa gat ggg gtt tcc ttc     3781
Ala Ser Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe
        945                 950                 955

atc agt cca ctg ggc atc ctg tac acc cca gct tta aaa gtg atg gaa     3829
Ile Ser Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu
    960                 965                 970

ggc cac ggg gaa gtg aat att aag cat tat cta aac tgc agt cac tgt     3877
Gly His Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys
975                 980                 985                 990

gag gta gac gaa tgt cac atg gac cct gaa  agc cac aag gtc atc  tgc   3925
Glu Val Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys
                995                 1000                 1005

ttc tgt gac cac  ggg acg gtg ctg gct  gag gat ggc gtc tcc  tgc      3970
Phe Cys Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys
            1010                 1015                 1020

att gtg tca ccc  acc ccg gag cca cac  ctg cca ctc tcg ctg  atc      4015
Ile Val Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile
            1025                 1030                 1035

ctc tct gtg gtg  acc tct gcc ctc gtg  gcc gcc ctg gtc ctg  gct      4060
Leu Ser Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala
            1040                 1045                 1050

ttc tcc ggc atc  atg att gtg tac cgc  cgg aag cac cag gag  ctg      4105
Phe Ser Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu
            1055                 1060                 1065

caa gcc atg cag  atg gag ctg cag agc  cct gag tac aag ctg  agc      4150
Gln Ala Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser
            1070                 1075                 1080

aag ctc cgc acc  tcg acc atc atg acc  gac tac aac ccc aac  tac      4195
Lys Leu Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr
            1085                 1090                 1095

tgc ttt gct ggc  aag acc tcc tcc atc  agt gac ctg aag gag  gtg      4240
Cys Phe Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val
            1100                 1105                 1110

ccg cgg aaa aac  atc acc ctc att cgg  ggt ctg ggc cat ggc  gcc      4285
Pro Arg Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala
            1115                 1120                 1125

ttt ggg gag gtg  tat gaa ggc cag gtg  tcc gga atg ccc aac  gac      4330
Phe Gly Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp
            1130                 1135                 1140

cca agc ccc ctg  caa gtg gct gtg aag  acg ctg cct gaa gtg  tgc      4375
Pro Ser Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys
            1145                 1150                 1155

tct gaa cag gac  gaa ctg gat ttc ctc  atg gaa gcc ctg atc  atc      4420
Ser Glu Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile
            1160                 1165                 1170

agc aaa ttc aac  cac cag aac att gtt  cgc tgc att ggg gtg  agc      4465
Ser Lys Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser
            1175                 1180                 1185

ctg caa tcc ctg  ccc cgg ttc atc ctg  ctg gag ctc atg gcg  ggg      4510
Leu Gln Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly
            1190                 1195                 1200

gga gac ctc aag  tcc ttc ctc cga gag  acc cgc cct cgc ccg  agc      4555
Gly Asp Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser
            1205                 1210                 1215

cag ccc tcc tcc  ctg gcc atg ctg gac  ctt ctg cac gtg gct  cgg      4600
Gln Pro Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg
            1220                 1225                 1230

gac att gcc tgt  ggc tgt cag tat ttg  gag gaa aac cac ttc  atc      4645
Asp Ile Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile
            1235                 1240                 1245

cac cga gac att  gct gcc aga aac tgc  ctc ttg acc tgt cca  ggc      4690
His Arg Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly
            1250                 1255                 1260

cct gga aga gtg  gcc aag att gga gac  ttc ggg atg gcc cga  gac      4735
Pro Gly Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp
            1265                 1270                 1275

atc tac agg gcg  agc tac tat aga aag  gga ggc tgt gcc atg  ctg      4780
Ile Tyr Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu
            1280                 1285                 1290

cca gtt aag tgg  atg ccc cca gag gcc  ttc atg gaa gga ata  ttc      4825
Pro Val Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe
            1295                 1300                 1305

act tct aaa aca  gac aca tgg tcc ttt  gga gtg ctg cta tgg  gaa      4870
Thr Ser Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu
            1310                 1315                 1320

atc ttt tct ctt  gga tat atg cca tac  ccc agc aaa agc aac  cag      4915
Ile Phe Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln
            1325                 1330                 1335

gaa gtt ctg gag  ttt gtc acc agt gga  ggc cgg atg gac cca  ccc      4960
Glu Val Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro
            1340                 1345                 1350

aag aac tgc cct  ggg cct gta tac cgg  ata atg act cag tgc  tgg      5005
Lys Asn Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp
            1355                 1360                 1365

caa cat cag cct  gaa gac agg ccc aac  ttt gcc atc att ttg  gag      5050
Gln His Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu
            1370                 1375                 1380

agg att gaa tac  tgc acc cag gac ccg  gat gta atc aac acc  gct      5095
Arg Ile Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala
            1385                 1390                 1395

ttg ccg ata gaa  tat ggt cca ctt gtg  gaa gag gaa gag aaa  gtg      5140
Leu Pro Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val
            1400                 1405                 1410

cct gtg agg ccc  aag gac cct gag ggg  gtt cct cct ctc ctg  gtc      5185
Pro Val Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val
            1415                 1420                 1425

tct caa cag gca  aaa cgg gag gag gag  cgc agc cca gct gcc  cca      5230
Ser Gln Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro
            1430                 1435                 1440

cca cct ctg cct  acc acc tcc tct ggc  aag gct gca aag aaa  ccc      5275
Pro Pro Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro
            1445                 1450                 1455

aca gct gca gag  atc tct gtt cga gtc  cct aga ggg ccg gcc  gtg      5320
Thr Ala Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val
            1460                 1465                 1470

gaa ggg gga cac  gtg aat atg gca ttc  tct cag tcc aac cct  cct      5365
Glu Gly Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro
            1475                 1480                 1485

tcg gag ttg cac  aag gtc cac gga tcc  aga aac aag ccc acc  agc      5410
Ser Glu Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser
            1490                 1495                 1500

ttg tgg aac cca  acg tac ggc tcc tgg  ttt aca gag aaa ccc  acc      5455
Leu Trp Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr
            1505                 1510                 1515

aaa aag aat aat  cct ata gca aag aag  gag cca cac gac agg  ggt      5500
Lys Lys Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly
            1520                 1525                 1530

aac ctg ggg ctg  gag gga agc tgt act  gtc cca cct aac gtt  gca      5545
Asn Leu Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala
            1535                 1540                 1545

act ggg aga ctt  ccg ggg gcc tca ctg  ctc cta gag ccc tct  tcg      5590
Thr Gly Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser
            1550                 1555                 1560

ctg act gcc aat  atg aag gag gta cct  ctg ttc agg cta cgt  cac      5635
Leu Thr Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His
            1565                 1570                 1575

ttc cct tgt ggg  aat gtc aat tac ggc  tac cag caa cag ggc  ttg      5680
Phe Pro Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu
            1580                 1585                 1590

ccc tta gaa gcc  gct act gcc cct gga  gct ggt cat tac gag  gat      5725
Pro Leu Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp
            1595                 1600                 1605

acc att ctg aaa  agc aag aat agc atg  aac cag cct ggg ccc  tga      5770
Thr Ile Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro
            1610                 1615                 1620

gctcggtcgc acactcactt ctcttccttg ggatccctaa gaccgtggag gagagagagg   5830

caatggctcc ttcacaaacc agagaccaaa tgtcacgttt tgttttgtgc caacctattt   5890

tgaagtacca ccaaaaaagc tgtattttga aaatgcttta gaaaggtttt gagcatgggt   5950

tcatcctatt ctttcgaaag aagaaaatat cataaaaatg agtgataaat acaaggccca   6010

gatgtggttg cataaggttt ttatgcatgt ttgttgtata cttccttatg cttctttcaa   6070

attgtgtgtg ctctgcttca atgtagtcag aattagctgc ttctatgttt catagttggg   6130

gtcatagatg tttccttgcc ttgttgatgt ggacatgagc catttgaggg gagagggaac   6190

ggaaataaag gagttatttg taatgactaa aa                                 6222


<210>  26
<211>  1620
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr
1               5                   10                  15


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro
            20                  25                  30


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg
        35                  40                  45


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe
    50                  55                  60


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu
65                  70                  75                  80


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala
                85                  90                  95


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala
            100                 105                 110


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys
        115                 120                 125


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu
    130                 135                 140


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu
145                 150                 155                 160


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp
                165                 170                 175


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu
            180                 185                 190


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile
        195                 200                 205


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His
    210                 215                 220


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr
225                 230                 235                 240


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu
                245                 250                 255


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys
            260                 265                 270


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp
        275                 280                 285


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu
    290                 295                 300


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe
305                 310                 315                 320


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro
                325                 330                 335


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His
            340                 345                 350


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His
        355                 360                 365


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His
    370                 375                 380


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe
385                 390                 395                 400


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala
                405                 410                 415


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly
            420                 425                 430


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val
        435                 440                 445


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly
    450                 455                 460


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys
465                 470                 475                 480


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro
                485                 490                 495


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln
            500                 505                 510


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala
        515                 520                 525


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys
    530                 535                 540


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu
545                 550                 555                 560


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu
                565                 570                 575


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu
            580                 585                 590


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp
        595                 600                 605


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala
    610                 615                 620


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly
625                 630                 635                 640


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe
                645                 650                 655


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg
            660                 665                 670


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys
        675                 680                 685


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala
    690                 695                 700


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu
705                 710                 715                 720


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile
                725                 730                 735


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met
            740                 745                 750


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp
        755                 760                 765


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro
    770                 775                 780


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val
785                 790                 795                 800


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly
                805                 810                 815


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp
            820                 825                 830


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala
        835                 840                 845


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn
    850                 855                 860


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly
865                 870                 875                 880


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu
                885                 890                 895


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys
            900                 905                 910


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys
        915                 920                 925


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser
    930                 935                 940


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser
945                 950                 955                 960


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His
                965                 970                 975


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val
            980                 985                 990


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys
        995                 1000                 1005


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val
    1010                 1015                 1020


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser
    1025                 1030                 1035


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser
    1040                 1045                 1050


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala
    1055                 1060                 1065


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu
    1070                 1075                 1080


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe
    1085                 1090                 1095


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg
    1100                 1105                 1110


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly
    1115                 1120                 1125


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser
    1130                 1135                 1140


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu
    1145                 1150                 1155


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys
    1160                 1165                 1170


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln
    1175                 1180                 1185


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp
    1190                 1195                 1200


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro
    1205                 1210                 1215


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile
    1220                 1225                 1230


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg
    1235                 1240                 1245


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly
    1250                 1255                 1260


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr
    1265                 1270                 1275


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val
    1280                 1285                 1290


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser
    1295                 1300                 1305


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe
    1310                 1315                 1320


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val
    1325                 1330                 1335


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn
    1340                 1345                 1350


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His
    1355                 1360                 1365


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile
    1370                 1375                 1380


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro
    1385                 1390                 1395


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val
    1400                 1405                 1410


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln
    1415                 1420                 1425


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro
    1430                 1435                 1440


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala
    1445                 1450                 1455


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly
    1460                 1465                 1470


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu
    1475                 1480                 1485


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp
    1490                 1495                 1500


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys
    1505                 1510                 1515


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu
    1520                 1525                 1530


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly
    1535                 1540                 1545


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr
    1550                 1555                 1560


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro
    1565                 1570                 1575


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu
    1580                 1585                 1590


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile
    1595                 1600                 1605


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro
    1610                 1615                 1620


