                         SEQUENCE LISTING

<110>  Morphotek, Inc.
       Zhou, Yuhong
       Tomkowicz, Brian
       Grasso, Luigi
       Nicolaides, Nicholas
       Sass, Philip M.
 
<120>  METHODS FOR INHIBITING THE BINDING OF ENDOSIALIN TO LIGANDS

<130>  MOR-0727

<150>  US 60/910,362
<151>  2007-04-05

<150>  US 60/980,026
<151>  2007-10-15

<160>  35    

<170>  PatentIn version 3.3

<210>  1
<211>  2660
<212>  DNA
<213>  Mus musculus

<400>  1
gtcaagagca gcggcaggcc cgagccgggc cagtcggggg gcgtcgcgat gctgctgcgc     60

ctgctgctgg cctgggtggc cgcggtgccc gcactgggcc aggtcccctg gacgccggag    120

cctcgagccg cgtgcggccc cagcagctgc tacgcgctct ttccccggcg ccgcacattc    180

ctggaagctt ggcgggcgtg ccgcgaattg gggggcaacc tggccacacc gcggacccca    240

gaggaggccc agcgtgtgga cagcctggtg ggggtcgggc cggccaacgg gctgctatgg    300

attgggttgc agcggcaggc taggcaatgc cagccgcagc gcccactgcg gggcttcata    360

tggaccacgg gagaccagga caccgccttc accaactggg cccagccggc tacggaagga    420

ccctgcccag cccagcgctg tgcagccctt gaggccagcg gagagcatcg ctggctcgaa    480

ggctcgtgca cactggctgt cgatggctac ctctgccagt ttggttttga gggtgcctgc    540

cctgccttgc cgcttgaggt gggtcaggcc ggtcccgctg tctacaccac acccttcaac    600

ctggtttcca gcgagttcga atggctgccc tttggctccg tggcagctgt gcagtgccaa    660

gctggcaggg gagcttctct gctgtgcgtg aaacagcctt caggtggcgt gggctggtcc    720

cagactggcc cgctgtgccc agggactggc tgtggtcctg acaatggggg ttgcgaacat    780

gagtgtgtgg aagaggtgga cggtgctgtg tcctgccgct gcagtgaagg cttccgtcta    840

gcagcagatg ggcacagttg tgaagacccc tgtgcccagg ccccctgtga gcagcagtgt    900

gaacctggag ggccacaagg ctatagctgc cactgtcgcc ttggcttccg gccagctgag    960

gatgatccac accgctgcgt ggacacggat gagtgccaga ttgctggtgt gtgccagcag   1020

atgtgtgtca actatgttgg tggctttgag tgttactgca gcgagggtca cgagcttgag   1080

gcagatggta tcagctgtag ccctgcagga gccatgggtg cccaggcttc ccaggatctc   1140

agagatgagt tgctggatga tggagaagaa ggggaggatg aagaggagcc ctgggaggac   1200

tttgatggca cctggacaga ggaacagggg atcctatggc tggcacctac acatccacct   1260

gactttggcc tgccctatag gcccaacttc ccacaggatg gagagcctca gagattgcac   1320

ctggagccta cctggccacc cccacttagt gcccccaggg gcccctacca ctcctcagtg   1380

gtgtctgcca cacggcccat ggtgatctct gccactcgac ccacactacc ttctgcccac   1440

aagacctctg ttatttcagc tacacgccca cccctgagcc ctgtccaccc acctgccatg   1500

gcccctgcca cacctccagc tgtgttctct gagcaccaga tccccaaaat caaggccaat   1560

tatccagacc tgccttttgg ccacaagcct gggataacct cggccactca cccagcacgg   1620

tctcctccgt accagccccc cattatctca accaactatc cccaagtctt ccctccccac   1680

caggccccta tgtctccaga tacccacact atcacttatt tgcctccagt cccccctcac   1740

cttgatcctg gggataccac ttctaaagcc catcaacacc ctttgctccc agatgctcca   1800

ggtatcagaa cccaggcccc ccagctttct gtctcagctc tccagccccc tcttcctacc   1860

aactccaggt cttctgtcca tgaaactcct gtgcctgctg ccaaccagcc cccagccttc   1920

ccttcttctc ccctcccccc tcagaggccc actaaccaga cctcatctat cagccctaca   1980

cattcctatt ccagagcccc tctagtccca agggaaggag ttcccagtcc caaatcagtg   2040

ccacagctgc cctcggtgcc ctccacagca gctccaacag ccctggcaga gtcaggtctt   2100

gcaggccaaa gccaaaggga tgaccgctgg ctgctggtgg cactcctggt gccaacatgt   2160

gtcttcttgg tggtgctgct tgccctgggc attgtgtact gcactcgctg tggctcccac   2220

gcacccaaca agcggatcac ggactgctat cgctgggtca cacatgctgg gaacaagagc   2280

tcaacagaac ccatgccccc cagaggcagc cttacagggg tacagacctg tagaaccagt   2340

gtgtgatggg gtgcagatgc ccctttgtgg gatagaagaa aaggacttgc tttggacaca   2400

tggctgagac cacaccaagg acttatgggg gctgcccagc tgacagagga ggttctgttc   2460

tttgagccca gcatccatgg caaaggacac accaggactc caggacctca aggggtgggt   2520

gctgggatct tctccaataa atggggtgcc aacctcaccc aaaaaaaaaa aaaaaaaaaa   2580

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2640

aaaaaaaaaa aaaaaaaaaa                                               2660


<210>  2
<211>  765
<212>  PRT
<213>  Mus musculus

<400>  2

Met Leu Leu Arg Leu Leu Leu Ala Trp Val Ala Ala Val Pro Ala Leu 
1               5                   10                  15      


Gly Gln Val Pro Trp Thr Pro Glu Pro Arg Ala Ala Cys Gly Pro Ser 
            20                  25                  30          


Ser Cys Tyr Ala Leu Phe Pro Arg Arg Arg Thr Phe Leu Glu Ala Trp 
        35                  40                  45              


Arg Ala Cys Arg Glu Leu Gly Gly Asn Leu Ala Thr Pro Arg Thr Pro 
    50                  55                  60                  


Glu Glu Ala Gln Arg Val Asp Ser Leu Val Gly Val Gly Pro Ala Asn 
65                  70                  75                  80  


Gly Leu Leu Trp Ile Gly Leu Gln Arg Gln Ala Arg Gln Cys Gln Pro 
                85                  90                  95      


Gln Arg Pro Leu Arg Gly Phe Ile Trp Thr Thr Gly Asp Gln Asp Thr 
            100                 105                 110         


Ala Phe Thr Asn Trp Ala Gln Pro Ala Thr Glu Gly Pro Cys Pro Ala 
        115                 120                 125             


Gln Arg Cys Ala Ala Leu Glu Ala Ser Gly Glu His Arg Trp Leu Glu 
    130                 135                 140                 


Gly Ser Cys Thr Leu Ala Val Asp Gly Tyr Leu Cys Gln Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Ala Cys Pro Ala Leu Pro Leu Glu Val Gly Gln Ala Gly Pro 
                165                 170                 175     


Ala Val Tyr Thr Thr Pro Phe Asn Leu Val Ser Ser Glu Phe Glu Trp 
            180                 185                 190         


Leu Pro Phe Gly Ser Val Ala Ala Val Gln Cys Gln Ala Gly Arg Gly 
        195                 200                 205             


Ala Ser Leu Leu Cys Val Lys Gln Pro Ser Gly Gly Val Gly Trp Ser 
    210                 215                 220                 


Gln Thr Gly Pro Leu Cys Pro Gly Thr Gly Cys Gly Pro Asp Asn Gly 
225                 230                 235                 240 


Gly Cys Glu His Glu Cys Val Glu Glu Val Asp Gly Ala Val Ser Cys 
                245                 250                 255     


Arg Cys Ser Glu Gly Phe Arg Leu Ala Ala Asp Gly His Ser Cys Glu 
            260                 265                 270         


Asp Pro Cys Ala Gln Ala Pro Cys Glu Gln Gln Cys Glu Pro Gly Gly 
        275                 280                 285             


Pro Gln Gly Tyr Ser Cys His Cys Arg Leu Gly Phe Arg Pro Ala Glu 
    290                 295                 300                 


Asp Asp Pro His Arg Cys Val Asp Thr Asp Glu Cys Gln Ile Ala Gly 
305                 310                 315                 320 


Val Cys Gln Gln Met Cys Val Asn Tyr Val Gly Gly Phe Glu Cys Tyr 
                325                 330                 335     


Cys Ser Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser Cys Ser Pro 
            340                 345                 350         


Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu Arg Asp Glu Leu 
        355                 360                 365             


Leu Asp Asp Gly Glu Glu Gly Glu Asp Glu Glu Glu Pro Trp Glu Asp 
    370                 375                 380                 


Phe Asp Gly Thr Trp Thr Glu Glu Gln Gly Ile Leu Trp Leu Ala Pro 
385                 390                 395                 400 


Thr His Pro Pro Asp Phe Gly Leu Pro Tyr Arg Pro Asn Phe Pro Gln 
                405                 410                 415     


Asp Gly Glu Pro Gln Arg Leu His Leu Glu Pro Thr Trp Pro Pro Pro 
            420                 425                 430         


Leu Ser Ala Pro Arg Gly Pro Tyr His Ser Ser Val Val Ser Ala Thr 
        435                 440                 445             


Arg Pro Met Val Ile Ser Ala Thr Arg Pro Thr Leu Pro Ser Ala His 
    450                 455                 460                 


Lys Thr Ser Val Ile Ser Ala Thr Arg Pro Pro Leu Ser Pro Val His 
465                 470                 475                 480 


Pro Pro Ala Met Ala Pro Ala Thr Pro Pro Ala Val Phe Ser Glu His 
                485                 490                 495     


Gln Ile Pro Lys Ile Lys Ala Asn Tyr Pro Asp Leu Pro Phe Gly His 
            500                 505                 510         


Lys Pro Gly Ile Thr Ser Ala Thr His Pro Ala Arg Ser Pro Pro Tyr 
        515                 520                 525             


Gln Pro Pro Ile Ile Ser Thr Asn Tyr Pro Gln Val Phe Pro Pro His 
    530                 535                 540                 


Gln Ala Pro Met Ser Pro Asp Thr His Thr Ile Thr Tyr Leu Pro Pro 
545                 550                 555                 560 


Val Pro Pro His Leu Asp Pro Gly Asp Thr Thr Ser Lys Ala His Gln 
                565                 570                 575     


His Pro Leu Leu Pro Asp Ala Pro Gly Ile Arg Thr Gln Ala Pro Gln 
            580                 585                 590         


Leu Ser Val Ser Ala Leu Gln Pro Pro Leu Pro Thr Asn Ser Arg Ser 
        595                 600                 605             


Ser Val His Glu Thr Pro Val Pro Ala Ala Asn Gln Pro Pro Ala Phe 
    610                 615                 620                 


Pro Ser Ser Pro Leu Pro Pro Gln Arg Pro Thr Asn Gln Thr Ser Ser 
625                 630                 635                 640 


Ile Ser Pro Thr His Ser Tyr Ser Arg Ala Pro Leu Val Pro Arg Glu 
                645                 650                 655     


Gly Val Pro Ser Pro Lys Ser Val Pro Gln Leu Pro Ser Val Pro Ser 
            660                 665                 670         


Thr Ala Ala Pro Thr Ala Leu Ala Glu Ser Gly Leu Ala Gly Gln Ser 
        675                 680                 685             


Gln Arg Asp Asp Arg Trp Leu Leu Val Ala Leu Leu Val Pro Thr Cys 
    690                 695                 700                 


Val Phe Leu Val Val Leu Leu Ala Leu Gly Ile Val Tyr Cys Thr Arg 
705                 710                 715                 720 


Cys Gly Ser His Ala Pro Asn Lys Arg Ile Thr Asp Cys Tyr Arg Trp 
                725                 730                 735     


Val Thr His Ala Gly Asn Lys Ser Ser Thr Glu Pro Met Pro Pro Arg 
            740                 745                 750         


Gly Ser Leu Thr Gly Val Gln Thr Cys Arg Thr Ser Val 
        755                 760                 765 


<210>  3
<211>  2576
<212>  DNA
<213>  Homo sapiens

<400>  3
agtccggggg catcgcgatg ctgctgcgcc tgttgctggc ctgggcggcc gcagggccca     60

cactgggcca ggacccctgg gctgctgagc cccgtgccgc ctgcggcccc agcagctgct    120

acgctctctt cccacggcgc cgcaccttcc tggaggcctg gcgggcctgc cgcgagctgg    180

ggggcgacct ggccactcct cggacccccg aggaggccca gcgtgtggac agcctggtgg    240

gtgcgggccc agccagccgg ctgctgtgga tcgggctgca gcggcaggcc cggcaatgcc    300

agctgcagcg cccactgcgc ggcttcacgt ggaccacagg ggaccaggac acggctttca    360

ccaactgggc ccagccagcc tctggaggcc cctgcccggc ccagcgctgt gtggccctgg    420

aggcaagtgg cgagcaccgc tggctggagg gctcgtgcac gctggctgtc gacggctacc    480

tgtgccagtt tggcttcgag ggcgcctgcc cggcgctgca agatgaggcg ggccaggccg    540

gcccagccgt gtataccacg cccttccacc tggtctccac agagtttgag tggctgccct    600

tcggctctgt ggccgctgtg cagtgccagg ctggcagggg agcctctctg ctctgcgtga    660

agcagcctga gggaggtgtg ggctggtcac gggctgggcc cctgtgcctg gggactggct    720

gcagccctga caacgggggc tgcgaacacg aatgtgtgga ggaggtggat ggtcacgtgt    780

cctgccgctg cactgagggc ttccggctgg cagcagacgg gcgcagttgc gaggacccct    840

gtgcccaggc tccgtgcgag cagcagtgtg agcccggtgg gccacaaggc tacagctgcc    900

actgtcgcct gggtttccgg ccagcggagg atgatccgca ccgctgtgtg gacacagatg    960

agtgccagat tgccggtgtg tgccagcaga tgtgtgtcaa ctacgttggt ggcttcgagt   1020

gttattgtag cgagggacat gagctggagg ctgatggcat cagctgcagc cctgcagggg   1080

ccatgggtgc ccaggcttcc caggacctcg gagatgagtt gctggatgac ggggaggatg   1140

aggaagatga agacgaggcc tggaaggcct tcaacggtgg ctggacggag atgcctggga   1200

tcctgtggat ggagcctacg cagccgcctg actttgccct ggcctataga ccgagcttcc   1260

cagaggacag agagccacag ataccctacc cggagcccac ctggccaccc ccgctcagtg   1320

cccccagggt cccctaccac tcctcagtgc tctccgtcac ccggcctgtg gtggtctctg   1380

ccacgcatcc cacactgcct tctgcccacc agcctcctgt gatccctgcc acacacccag   1440

ctttgtcccg tgaccaccag atccccgtga tcgcagccaa ctatccagat ctgccttctg   1500

cctaccaacc cggtattctc tctgtctctc attcagcaca gcctcctgcc caccagcccc   1560

ctatgatctc aaccaaatat ccggagctct tccctgccca ccagtccccc atgtttccag   1620

acacccgggt cgctggcacc cagaccacca ctcatttgcc tggaatccca cctaaccatg   1680

cccctctggt caccaccctc ggtgcccagc taccccctca agccccagat gcccttgtcc   1740

tcagaaccca ggccacccag cttcccatta tcccaactgc ccagccctct ctgaccacca   1800

cctccaggtc ccctgtgtct cctgcccatc aaatctctgt gcctgctgcc acccagcccg   1860

cagccctccc caccctcctg ccctctcaga gccccactaa ccagacctca cccatcagcc   1920

ctacacatcc ccattccaaa gccccccaaa tcccaaggga agatggcccc agtcccaagt   1980

tggccctgtg gctgccctca ccagctccca cagcagcccc aacagccctg ggggaggctg   2040

gtcttgccga gcacagccag agggatgacc ggtggctgct ggtggcactc ctggtgccaa   2100

cgtgtgtctt tttggtggtc ctgcttgcac tgggcatcgt gtactgcacc cgctgtggcc   2160

cccatgcacc caacaagcgc atcactgact gctatcgctg ggtcatccat gctgggagca   2220

agagcccaac agaacccatg ccccccaggg gcagcctcac aggggtgcag acctgcagaa   2280

ccagcgtgtg atggggtgca gacccccctc atggagtatg gggcgctgga cacatggccg   2340

gggctgcacc agggacccat gggggctgcc cagctggaca gatggcttcc tgctccccag   2400

gcccagccag ggtcctctct caaccactag acttggctct caggaactct gcttcctggc   2460

ccagcgctcg tgaccaagga tacaccaaag cccttaagac ctcagggggc gggtgctggg   2520

gtcttctcca ataaatgggg tgtcaacctt acccaaggaa aaaaaaaaaa aaaaaa       2576


<210>  4
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Leu Arg Leu Leu Leu Ala Trp Ala Ala Ala Gly Pro Thr Leu 
1               5                   10                  15      


Gly Gln Asp Pro Trp Ala Ala Glu Pro Arg Ala Ala Cys Gly Pro Ser 
            20                  25                  30          


Ser Cys Tyr Ala Leu Phe Pro Arg Arg Arg Thr Phe Leu Glu Ala Trp 
        35                  40                  45              


Arg Ala Cys Arg Glu Leu Gly Gly Asp Leu Ala Thr Pro Arg Thr Pro 
    50                  55                  60                  


Glu Glu Ala Gln Arg Val Asp Ser Leu Val Gly Ala Gly Pro Ala Ser 
65                  70                  75                  80  


Arg Leu Leu Trp Ile Gly Leu Gln Arg Gln Ala Arg Gln Cys Gln Leu 
                85                  90                  95      


Gln Arg Pro Leu Arg Gly Phe Thr Trp Thr Thr Gly Asp Gln Asp Thr 
            100                 105                 110         


Ala Phe Thr Asn Trp Ala Gln Pro Ala Ser Gly Gly Pro Cys Pro Ala 
        115                 120                 125             


Gln Arg Cys Val Ala Leu Glu Ala Ser Gly Glu His Arg Trp Leu Glu 
    130                 135                 140                 


Gly Ser Cys Thr Leu Ala Val Asp Gly Tyr Leu Cys Gln Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Ala Cys Pro Ala Leu Gln Asp Glu Ala Gly Gln Ala Gly Pro 
                165                 170                 175     


Ala Val Tyr Thr Thr Pro Phe His Leu Val Ser Thr Glu Phe Glu Trp 
            180                 185                 190         


Leu Pro Phe Gly Ser Val Ala Ala Val Gln Cys Gln Ala Gly Arg Gly 
        195                 200                 205             


Ala Ser Leu Leu Cys Val Lys Gln Pro Glu Gly Gly Val Gly Trp Ser 
    210                 215                 220                 


Arg Ala Gly Pro Leu Cys Leu Gly Thr Gly Cys Ser Pro Asp Asn Gly 
225                 230                 235                 240 


Gly Cys Glu His Glu Cys Val Glu Glu Val Asp Gly His Val Ser Cys 
                245                 250                 255     


Arg Cys Thr Glu Gly Phe Arg Leu Ala Ala Asp Gly Arg Ser Cys Glu 
            260                 265                 270         


Asp Pro Cys Ala Gln Ala Pro Cys Glu Gln Gln Cys Glu Pro Gly Gly 
        275                 280                 285             


Pro Gln Gly Tyr Ser Cys His Cys Arg Leu Gly Phe Arg Pro Ala Glu 
    290                 295                 300                 


Asp Asp Pro His Arg Cys Val Asp Thr Asp Glu Cys Gln Ile Ala Gly 
305                 310                 315                 320 


Val Cys Gln Gln Met Cys Val Asn Tyr Val Gly Gly Phe Glu Cys Tyr 
                325                 330                 335     


Cys Ser Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser Cys Ser Pro 
            340                 345                 350         


Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu Gly Asp Glu Leu 
        355                 360                 365             


Leu Asp Asp Gly Glu Asp Glu Glu Asp Glu Asp Glu Ala Trp Lys Ala 
    370                 375                 380                 


Phe Asn Gly Gly Trp Thr Glu Met Pro Gly Ile Leu Trp Met Glu Pro 
385                 390                 395                 400 


Thr Gln Pro Pro Asp Phe Ala Leu Ala Tyr Arg Pro Ser Phe Pro Glu 
                405                 410                 415     


Asp Arg Glu Pro Gln Ile Pro Tyr Pro Glu Pro Thr Trp Pro Pro Pro 
            420                 425                 430         


Leu Ser Ala Pro Arg Val Pro Tyr His Ser Ser Val Leu Ser Val Thr 
        435                 440                 445             


Arg Pro Val Val Val Ser Ala Thr His Pro Thr Leu Pro Ser Ala His 
    450                 455                 460                 


Gln Pro Pro Val Ile Pro Ala Thr His Pro Ala Leu Ser Arg Asp His 
465                 470                 475                 480 


Gln Ile Pro Val Ile Ala Ala Asn Tyr Pro Asp Leu Pro Ser Ala Tyr 
                485                 490                 495     


Gln Pro Gly Ile Leu Ser Val Ser His Ser Ala Gln Pro Pro Ala His 
            500                 505                 510         


Gln Pro Pro Met Ile Ser Thr Lys Tyr Pro Glu Leu Phe Pro Ala His 
        515                 520                 525             


Gln Ser Pro Met Phe Pro Asp Thr Arg Val Ala Gly Thr Gln Thr Thr 
    530                 535                 540                 


Thr His Leu Pro Gly Ile Pro Pro Asn His Ala Pro Leu Val Thr Thr 
545                 550                 555                 560 


Leu Gly Ala Gln Leu Pro Pro Gln Ala Pro Asp Ala Leu Val Leu Arg 
                565                 570                 575     


Thr Gln Ala Thr Gln Leu Pro Ile Ile Pro Thr Ala Gln Pro Ser Leu 
            580                 585                 590         


Thr Thr Thr Ser Arg Ser Pro Val Ser Pro Ala His Gln Ile Ser Val 
        595                 600                 605             


Pro Ala Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln 
    610                 615                 620                 


Ser Pro Thr Asn Gln Thr Ser Pro Ile Ser Pro Thr His Pro His Ser 
625                 630                 635                 640 


Lys Ala Pro Gln Ile Pro Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala 
                645                 650                 655     


Leu Trp Leu Pro Ser Pro Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly 
            660                 665                 670         


Glu Ala Gly Leu Ala Glu His Ser Gln Arg Asp Asp Arg Trp Leu Leu 
        675                 680                 685             


Val Ala Leu Leu Val Pro Thr Cys Val Phe Leu Val Val Leu Leu Ala 
    690                 695                 700                 


Leu Gly Ile Val Tyr Cys Thr Arg Cys Gly Pro His Ala Pro Asn Lys 
705                 710                 715                 720 


Arg Ile Thr Asp Cys Tyr Arg Trp Val Ile His Ala Gly Ser Lys Ser 
                725                 730                 735     


Pro Thr Glu Pro Met Pro Pro Arg Gly Ser Leu Thr Gly Val Gln Thr 
            740                 745                 750         


Cys Arg Thr Ser Val 
        755         


<210>  5
<211>  2397
<212>  DNA
<213>  Rattus rattus

<400>  5
atgctgctgc gcctgctgct ggcctgggcg gccgcggtgc ccgcactggg ccaggccccc     60

tggacgccgg agcctagagc cgcctgcggc cccagcagct gctacgctct ctttccccgg    120

cgccgcacat tcctggaggc ttggcggtcg tgccgcgaat tggggggcaa cctggccaca    180

ccgaggaccc cggaggaggc ccgacgtgtg gacagcctgg tgggcgtcgg acccgccaac    240

gggctgctat ggattgggtt gcagcggcag gctcggcaat gccagccaca gcgcccactg    300

cggggcttca tatggaccac gggagaccag gacaccgcct tcactaactg ggcccagccg    360

gctacggaag gaccctgccc ggcccagcgc tgtgctgccc ttgaggccag cggagaacat    420

cgctggctcg aaggctcgtg cacactggct gtcgatggct acctctgcca gtttggtttt    480

gagggtgcct gtcctgcctt gccgcttgag gtgggccaag ccggtccagc tatctacacc    540

acacccttca acctggtttc cagtgagttc gaatggctac cctttggctc cgtggcagct    600

gtgcagtgcc aagctggcag gggaacgtct ctgttgtgtg tgaaacaacc ttcaggtggc    660

gttggctggt cccagactgg cccactgtgt ccagggactg gctgtggtcc tgacaatggg    720

ggttgcgaac atgaatgtgt ggaagagttg gatggcggta tgtcctgccg ctgcagtgaa    780

ggcttccgtc tagcagcaga tgggcacagt tgtgaagacc cttgtgccca ggccccctgt    840

gagcagcagt gtgagcctgg tgggccacaa ggctacagct gccactgtcg cctaggcttc    900

cggccagctg aggatgagcc acaccgctgc gtggacacgg atgagtgcca gattgctggt    960

gtgtgccagc agatgtgtgt caactatgtt ggtggctttg agtgttactg cagggagggt   1020

catgagcttg aggcagatgg tatcagttgt agccctgcag gagctatggg tgcccaggct   1080

tcccaggatc ttagagacga gttgctggat gatggagaag aaggggagga tgaagaggag   1140

ccctgggagg acttcgatgg cacctggaca gaggagcagg ggaccctatg gatggcacct   1200

acacatccgc ctgactttgg cctgccctat aggcccaact tcccacagga tggagagcct   1260

cagagattgc acctggagcc tacctggcca cccccactta gcgcccccag gggcccctac   1320

cactcctcag tggtgtctgc cacacggccc atggtaatct ctgccactcg acccacacaa   1380

ccttctgccc gaaagacctc tgttatttca gccacacacc taccccttaa ccctgtccac   1440

ccacctgccc tagcccctac cacacctcca gccgtgctcc ctgagcacca gatccccaaa   1500

atcaaggcca gttatccaga cttgcctttt ggccacaagc ctgggataac ctcagccact   1560

cacccagcac agcctcctcc tcaccagccc cccatcatct caacgaaata tccccaagtc   1620

ttccctcccc agcaggcccc tatgtctcca gacacccaca ctatcactaa tttgcctcta   1680

atcccatctc accttgaccc tggggatacc acttcccaag ccggtcacca tcctttgctc   1740

ccagatgttc caggtatcag aacccaggct ccccaggttt ctgtctcagc tctccagccc   1800

tctctgccta ccaactccag gtcttctgtc catgaacccc ctgtgcctac tgccaaccag   1860

cccccagcct tcccttctcc cctgccccct cagagcccca ttaaccagac ctcatctatc   1920

agccctacac actcctattc cagagcccct caggtcccaa gggaaggagc tcccagtccc   1980

aaatcagtgc caaggctgca ctcagtggcc cccacagcag ctccaacagc cctggcagag   2040

ttgggtcttg caggccaaag ccagagagat gaccgatggc tgctggtggc actcttggta   2100

ccaacgtgtg tcttcttggt ggtcctgctc gcattgggca ttgtgtactg cactcgctgt   2160

ggctcccata cgcccaacaa gcgtatcact gactgctatc gctgggtcac gcatgctggg   2220

aacaagagct caacagaacc catgcccccc agatggacag agaaggttct gttccttgaa   2280

cccagcattc atggcaaagg acacactgaa ggactccagg acctcaaggg gtgggtgctg   2340

ggatcttctc caataaatgg cgtgccaacc tcacccaaag tccgtgatcc ccgctga      2397


<210>  6
<211>  798
<212>  PRT
<213>  Rattus rattus

<400>  6

Met Leu Leu Arg Leu Leu Leu Ala Trp Ala Ala Ala Val Pro Ala Leu 
1               5                   10                  15      


Gly Gln Ala Pro Trp Thr Pro Glu Pro Arg Ala Ala Cys Gly Pro Ser 
            20                  25                  30          


Ser Cys Tyr Ala Leu Phe Pro Arg Arg Arg Thr Phe Leu Glu Ala Trp 
        35                  40                  45              


Arg Ser Cys Arg Glu Leu Gly Gly Asn Leu Ala Thr Pro Arg Thr Pro 
    50                  55                  60                  


Glu Glu Ala Arg Arg Val Asp Ser Leu Val Gly Val Gly Pro Ala Asn 
65                  70                  75                  80  


Gly Leu Leu Trp Ile Gly Leu Gln Arg Gln Ala Arg Gln Cys Gln Pro 
                85                  90                  95      


Gln Arg Pro Leu Arg Gly Phe Ile Trp Thr Thr Gly Asp Gln Asp Thr 
            100                 105                 110         


Ala Phe Thr Asn Trp Ala Gln Pro Ala Thr Glu Gly Pro Cys Pro Ala 
        115                 120                 125             


Gln Arg Cys Ala Ala Leu Glu Ala Ser Gly Glu His Arg Trp Leu Glu 
    130                 135                 140                 


Gly Ser Cys Thr Leu Ala Val Asp Gly Tyr Leu Cys Gln Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Ala Cys Pro Ala Leu Pro Leu Glu Val Gly Gln Ala Gly Pro 
                165                 170                 175     


Ala Ile Tyr Thr Thr Pro Phe Asn Leu Val Ser Ser Glu Phe Glu Trp 
            180                 185                 190         


Leu Pro Phe Gly Ser Val Ala Ala Val Gln Cys Gln Ala Gly Arg Gly 
        195                 200                 205             


Thr Ser Leu Leu Cys Val Lys Gln Pro Ser Gly Gly Val Gly Trp Ser 
    210                 215                 220                 


Gln Thr Gly Pro Leu Cys Pro Gly Thr Gly Cys Gly Pro Asp Asn Gly 
225                 230                 235                 240 


Gly Cys Glu His Glu Cys Val Glu Glu Leu Asp Gly Gly Met Ser Cys 
                245                 250                 255     


Arg Cys Ser Glu Gly Phe Arg Leu Ala Ala Asp Gly His Ser Cys Glu 
            260                 265                 270         


Asp Pro Cys Ala Gln Ala Pro Cys Glu Gln Gln Cys Glu Pro Gly Gly 
        275                 280                 285             


Pro Gln Gly Tyr Ser Cys His Cys Arg Leu Gly Phe Arg Pro Ala Glu 
    290                 295                 300                 


Asp Glu Pro His Arg Cys Val Asp Thr Asp Glu Cys Gln Ile Ala Gly 
305                 310                 315                 320 


Val Cys Gln Gln Met Cys Val Asn Tyr Val Gly Gly Phe Glu Cys Tyr 
                325                 330                 335     


Cys Arg Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser Cys Ser Pro 
            340                 345                 350         


Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu Arg Asp Glu Leu 
        355                 360                 365             


Leu Asp Asp Gly Glu Glu Gly Glu Asp Glu Glu Glu Pro Trp Glu Asp 
    370                 375                 380                 


Phe Asp Gly Thr Trp Thr Glu Glu Gln Gly Thr Leu Trp Met Ala Pro 
385                 390                 395                 400 


Thr His Pro Pro Asp Phe Gly Leu Pro Tyr Arg Pro Asn Phe Pro Gln 
                405                 410                 415     


Asp Gly Glu Pro Gln Arg Leu His Leu Glu Pro Thr Trp Pro Pro Pro 
            420                 425                 430         


Leu Ser Ala Pro Arg Gly Pro Tyr His Ser Ser Val Val Ser Ala Thr 
        435                 440                 445             


Arg Pro Met Val Ile Ser Ala Thr Arg Pro Thr Gln Pro Ser Ala Arg 
    450                 455                 460                 


Lys Thr Ser Val Ile Ser Ala Thr His Leu Pro Leu Asn Pro Val His 
465                 470                 475                 480 


Pro Pro Ala Leu Ala Pro Thr Thr Pro Pro Ala Val Leu Pro Glu His 
                485                 490                 495     


Gln Ile Pro Lys Ile Lys Ala Ser Tyr Pro Asp Leu Pro Phe Gly His 
            500                 505                 510         


Lys Pro Gly Ile Thr Ser Ala Thr His Pro Ala Gln Pro Pro Pro His 
        515                 520                 525             


Gln Pro Pro Ile Ile Ser Thr Lys Tyr Pro Gln Val Phe Pro Pro Gln 
    530                 535                 540                 


Gln Ala Pro Met Ser Pro Asp Thr His Thr Ile Thr Asn Leu Pro Leu 
545                 550                 555                 560 


Ile Pro Ser His Leu Asp Pro Gly Asp Thr Thr Ser Gln Ala Gly His 
                565                 570                 575     


His Pro Leu Leu Pro Asp Val Pro Gly Ile Arg Thr Gln Ala Pro Gln 
            580                 585                 590         


Val Ser Val Ser Ala Leu Gln Pro Ser Leu Pro Thr Asn Ser Arg Ser 
        595                 600                 605             


Ser Val His Glu Pro Pro Val Pro Thr Ala Asn Gln Pro Pro Ala Phe 
    610                 615                 620                 


Pro Ser Pro Leu Pro Pro Gln Ser Pro Ile Asn Gln Thr Ser Ser Ile 
625                 630                 635                 640 


Ser Pro Thr His Ser Tyr Ser Arg Ala Pro Gln Val Pro Arg Glu Gly 
                645                 650                 655     


Ala Pro Ser Pro Lys Ser Val Pro Arg Leu His Ser Val Ala Pro Thr 
            660                 665                 670         


Ala Ala Pro Thr Ala Leu Ala Glu Leu Gly Leu Ala Gly Gln Ser Gln 
        675                 680                 685             


Arg Asp Asp Arg Trp Leu Leu Val Ala Leu Leu Val Pro Thr Cys Val 
    690                 695                 700                 


Phe Leu Val Val Leu Leu Ala Leu Gly Ile Val Tyr Cys Thr Arg Cys 
705                 710                 715                 720 


Gly Ser His Thr Pro Asn Lys Arg Ile Thr Asp Cys Tyr Arg Trp Val 
                725                 730                 735     


Thr His Ala Gly Asn Lys Ser Ser Thr Glu Pro Met Pro Pro Arg Trp 
            740                 745                 750         


Thr Glu Lys Val Leu Phe Leu Glu Pro Ser Ile His Gly Lys Gly His 
        755                 760                 765             


Thr Glu Gly Leu Gln Asp Leu Lys Gly Trp Val Leu Gly Ser Ser Pro 
    770                 775                 780                 


Ile Asn Gly Val Pro Thr Ser Pro Lys Val Arg Asp Pro Arg 
785                 790                 795             


<210>  7
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence encoding light chain of antibodies M4 and 
       M4.1 with leader sequence

<400>  7
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt ccactccgac     60

atccagatga cccagagccc aagcagcctg agcgccagcg tgggtgacag agtgaccatc    120

acctgtagag ccagccagaa tgtgggtact gctgtagcct ggctacagca gaccccaggt    180

aaggctccaa agctgctgat ctactcggca tcgaatcggt acactggtgt gccaagcaga    240

ttcagcggta gcggtagcgg taccgactac accttcacca tcagcagcct ccagccagag    300

gacatcgcca cctactactg ccagcaatat accaactatc ccatgtacac gttcggccaa    360

gggaccaagg tgcaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag    540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg    600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc    660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttaa                    705


<210>  8
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence encoding heavy chain of antibody M4 with 
       leader sequence

<400>  8
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt ccactcccag     60

gtccaactgc aggagagcgg tccaggtctt gtgagaccta gccagaccct gagcctgacc    120

tgcaccgcgt ctggctacac cttcactgac tatgttatac actgggtgaa acagccacct    180

ggacgaggtc ttgagtggat tggatatatt aatccttatg atgatgatac tacctacaac    240

cagaagttca agggcagagt gacaatgctg gtagacacca gctccaacac agcctacctg    300

agactcagca gcgtgacagc cgaggacacc gcggtctatt attgtgcaag aagggggaat    360

tcctatgatg gttactttga ctactctatg gactactggg gatccgggac cccggtcacc    420

gtctcctcag cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc    480

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg    540

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta    600

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc    660

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa    720

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc    780

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc    840

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag    900

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag    960

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg   1020

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa   1080

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc   1140

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc   1200

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg   1260

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag   1320

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac   1380

cactacacgc agaagagcct ctccctgtct cccgggaaat ga                      1422


<210>  9
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of light chain of antibodies M4 and M4.1 with
       leader sequence

<400>  9

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val 
        35                  40                  45              


Gly Thr Ala Val Ala Trp Leu Gln Gln Thr Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Asn 
            100                 105                 110         


Tyr Pro Met Tyr Thr Phe Gly Gln Gly Thr Lys Val Gln Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  10
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence encoding light chain of antibodies M4 and 
       M4.1 without leader sequence

<400>  10
gacatccaga tgacccagag cccaagcagc ctgagcgcca gcgtgggtga cagagtgacc     60

atcacctgta gagccagcca gaatgtgggt actgctgtag cctggctaca gcagacccca    120

ggtaaggctc caaagctgct gatctactcg gcatcgaatc ggtacactgg tgtgccaagc    180

agattcagcg gtagcggtag cggtaccgac tacaccttca ccatcagcag cctccagcca    240

gaggacatcg ccacctacta ctgccagcaa tataccaact atcccatgta cacgttcggc    300

caagggacca aggtgcaaat caaacgaact gtggctgcac catctgtctt catcttcccg    360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc    420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc    480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg    540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag    600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttaa                 648


<210>  11
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of light chain of antibodies M4 and M4.1 
       without leader sequence

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Leu Gln Gln Thr Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Asn Tyr Pro Met 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Gln Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  12
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence encoding CDR1 of light chain of antibodies 
       M4 and M4.1

<400>  12
agagccagcc agaatgtggg tactgctgta gcc                                  33


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of CDR1 of light chain of antibodies M4 and 
       M4.1

<400>  13

Arg Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence encoding CDR2 of light chain of antibodies M4
       and M4.1

<400>  14
tcggcatcga atcggtacac t                                               21


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of CDR2 of light chain of antibodies M4 and 
       M4.1

<400>  15

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  16
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence encoding CDR3 of light chain of antibodies M4
       and M4.1

<400>  16
cagcaatata ccaactatcc catgtacacg                                      30


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of CDR3 of light chain of antibodies M4 and 
       M4.1

<400>  17

Gln Gln Tyr Thr Asn Tyr Pro Met Tyr Thr 
1               5                   10  


<210>  18
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence encoding variable domain of light chain of 
       antibodies M4 and M4.1

<400>  18
gacatccaga tgacccagag cccaagcagc ctgagcgcca gcgtgggtga cagagtgacc     60

atcacctgta gagccagcca gaatgtgggt actgctgtag cctggctaca gcagacccca    120

ggtaaggctc caaagctgct gatctactcg gcatcgaatc ggtacactgg tgtgccaagc    180

agattcagcg gtagcggtag cggtaccgac tacaccttca ccatcagcag cctccagcca    240

gaggacatcg ccacctacta ctgccagcaa tataccaact atcccatgta cacg          294


<210>  19
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of variable domain of light chain of 
       antibodies M4 and M4.1

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Leu Gln Gln Thr Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Asn Tyr Pro Met 
                85                  90                  95      


Tyr Thr 
        


<210>  20
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of heavy chain of antibody M4 plus leader 
       sequence

<400>  20

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Val Ile His Trp Val Lys Gln Pro Pro Gly Arg Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asp Asp Asp Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Val Thr Met Leu Val Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Arg Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Gly Asn Ser Tyr Asp Gly Tyr Phe Asp Tyr 
        115                 120                 125             


Ser Met Asp Tyr Trp Gly Ser Gly Thr Pro Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  21
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence encoding heavy chain of antibody M4 without 
       leader sequence

<400>  21
caggtccaac tgcaggagag cggtccaggt cttgtgagac ctagccagac cctgagcctg     60

acctgcaccg cgtctggcta caccttcact gactatgtta tacactgggt gaaacagcca    120

cctggacgag gtcttgagtg gattggatat attaatcctt atgatgatga tactacctac    180

aaccagaagt tcaagggcag agtgacaatg ctggtagaca ccagctccaa cacagcctac    240

ctgagactca gcagcgtgac agccgaggac accgcggtct attattgtgc aagaaggggg    300

aattcctatg atggttactt tgactactct atggactact ggggatccgg gaccccggtc    360

accgtctcct cagcctccac caagggccca tcggtcttcc ccctggcacc ctcctccaag    420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg    480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc    540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg    600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag    660

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa    720

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc    780

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc    840

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag    900

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg    960

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag   1020

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca   1080

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat   1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc   1200

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac   1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac   1320

aaccactaca cgcagaagag cctctccctg tctcccggga aatga                   1365


<210>  22
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of heavy chain of antibody M4 without leader 
       sequence

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asp Asp Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Leu Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asn Ser Tyr Asp Gly Tyr Phe Asp Tyr Ser Met Asp 
            100                 105                 110         


Tyr Trp Gly Ser Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  23
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence encoding heavy chain of antibody M4.1 with 
       leader sequence

<400>  23
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt ccactcccag     60

gtccaactgc aggagagcgg tccaggtctt gtgagaccta gccagaccct gagcctgacc    120

tgcaccgcgt ctggctacac cttcactgac tatgttatac actgggtgaa acagccacct    180

ggacgaggtc ttgagtggat tggatatatt aatccttatg atgatgatac tacctacaac    240

cagaagttca agggcagagt gacaatgctg gtagacacca gctccaacac agcctacctg    300

agactcagca gcgtgacagc cgaggacacc gcggtctatt attgtgcaag aagggggaat    360

tcctatgatg gttactttga ctactctatg gactactggg gatccgggac cccggtcacc    420

gtctcctcag cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc    480

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg    540

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta    600

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc    660

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa    720

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc    780

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc    840

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag    900

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag    960

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg   1020

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa   1080

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc   1140

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc   1200

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg   1260

cctcccgtgc tggactccga cggcttcttc ttcctctaca gcaagctcac cgtggacaag   1320

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac   1380

cactacacgc agaagagcct ctccctgtct cccgggaaat ga                      1422


<210>  24
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of heavy chain of antibody M4.1 with leader 
       sequence

<400>  24

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Val Ile His Trp Val Lys Gln Pro Pro Gly Arg Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asp Asp Asp Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Val Thr Met Leu Val Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Arg Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Gly Asn Ser Tyr Asp Gly Tyr Phe Asp Tyr 
        115                 120                 125             


Ser Met Asp Tyr Trp Gly Ser Gly Thr Pro Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Phe Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  25
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence encoding heavy chain of antibody M4.1 without
       leader sequence

<400>  25
caggtccaac tgcaggagag cggtccaggt cttgtgagac ctagccagac cctgagcctg     60

acctgcaccg cgtctggcta caccttcact gactatgtta tacactgggt gaaacagcca    120

cctggacgag gtcttgagtg gattggatat attaatcctt atgatgatga tactacctac    180

aaccagaagt tcaagggcag agtgacaatg ctggtagaca ccagctccaa cacagcctac    240

ctgagactca gcagcgtgac agccgaggac accgcggtct attattgtgc aagaaggggg    300

aattcctatg atggttactt tgactactct atggactact ggggatccgg gaccccggtc    360

accgtctcct cagcctccac caagggccca tcggtcttcc ccctggcacc ctcctccaag    420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg    480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc    540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg    600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag    660

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa    720

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc    780

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc    840

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag    900

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg    960

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag   1020

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca   1080

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat   1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc   1200

acgcctcccg tgctggactc cgacggcttc ttcttcctct acagcaagct caccgtggac   1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac   1320

aaccactaca cgcagaagag cctctccctg tctcccggga aatga                   1365


<210>  26
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of heavy chain of antibody M4.1 without 
       leader sequence

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asp Asp Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Leu Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asn Ser Tyr Asp Gly Tyr Phe Asp Tyr Ser Met Asp 
            100                 105                 110         


Tyr Trp Gly Ser Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Phe Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  27
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence encoding CDR1 of heavy chain of antibodies M4
       and M4.1

<400>  27
ggctacacct tcactgacta tgttatacac                                      30


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of CDR1 of heavy chain of antibodies M4 and 
       M4.1

<400>  28

Gly Tyr Thr Phe Thr Asp Tyr Val Ile His 
1               5                   10  


<210>  29
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence encoding CDR2 of heavy chain of antibodies M4
       and M4.1

<400>  29
tatattaatc cttatgatga tgatactacc tacaaccaga agttcaaggg c              51


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of CDR2 of heavy chain of antibodies M4 and 
       M4.1

<400>  30

Tyr Ile Asn Pro Tyr Asp Asp Asp Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence encoding CDR3 of heavy chain of Antibodies M4
       and M4.1

<400>  31
gcaagaaggg ggaattccta tgatggttac tttgactact ctatggacta c              51


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of heavy chain CDR3 of antibodies M4 and M4.1

<400>  32

Ala Arg Arg Gly Asn Ser Tyr Asp Gly Tyr Phe Asp Tyr Ser Met Asp 
1               5                   10                  15      


Tyr 
    


<210>  33
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence encoding variable domain of heavy chain of 
       antibodies M4 and M4.1

<400>  33
caggtccaac tgcaggagag cggtccaggt cttgtgagac ctagccagac cctgagcctg     60

acctgcaccg cgtctggcta caccttcact gactatgtta tacactgggt gaaacagcca    120

cctggacgag gtcttgagtg gattggatat attaatcctt atgatgatga tactacctac    180

aaccagaagt tcaagggcag agtgacaatg ctggtagaca ccagctccaa cacagcctac    240

ctgagactca gcagcgtgac agccgaggac accgcggtct attattgtgc aagaaggggg    300

aattcctatg atggttactt tgactactct atggactac                           339


<210>  34
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of variable domain of heavy chain of 
       antibodies M4 and M4.1

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asp Asp Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Leu Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asn Ser Tyr Asp Gly Tyr Phe Asp Tyr Ser Met Asp 
            100                 105                 110         


Tyr 
    


<210>  35
<211>  2477
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Glu Val Pro Gln Leu  Thr Asp Leu Ser Phe  Val Asp Ile 
    1265                 1270                 1275             


Thr Asp  Ser Ser Ile Gly Leu  Arg Trp Thr Pro Leu  Asn Ser Ser 
    1280                 1285                 1290             


Thr Ile  Ile Gly Tyr Arg Ile  Thr Val Val Ala Ala  Gly Glu Gly 
    1295                 1300                 1305             


Ile Pro  Ile Phe Glu Asp Phe  Val Asp Ser Ser Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Thr Val  Thr Gly Leu Glu Pro  Gly Ile Asp Tyr Asp  Ile Ser Val 
    1325                 1330                 1335             


Ile Thr  Leu Ile Asn Gly Gly  Glu Ser Ala Pro Thr  Thr Leu Thr 
    1340                 1345                 1350             


Gln Gln  Thr Ala Val Pro Pro  Pro Thr Asp Leu Arg  Phe Thr Asn 
    1355                 1360                 1365             


Ile Gly  Pro Asp Thr Met Arg  Val Thr Trp Ala Pro  Pro Pro Ser 
    1370                 1375                 1380             


Ile Asp  Leu Thr Asn Phe Leu  Val Arg Tyr Ser Pro  Val Lys Asn 
    1385                 1390                 1395             


Glu Glu  Asp Val Ala Glu Leu  Ser Ile Ser Pro Ser  Asp Asn Ala 
    1400                 1405                 1410             


Val Val  Leu Thr Asn Leu Leu  Pro Gly Thr Glu Tyr  Val Val Ser 
    1415                 1420                 1425             


Val Ser  Ser Val Tyr Glu Gln  His Glu Ser Thr Pro  Leu Arg Gly 
    1430                 1435                 1440             


Arg Gln  Lys Thr Gly Leu Asp  Ser Pro Thr Gly Ile  Asp Phe Ser 
    1445                 1450                 1455             


Asp Ile  Thr Ala Asn Ser Phe  Thr Val His Trp Ile  Ala Pro Arg 
    1460                 1465                 1470             


Ala Thr  Ile Thr Gly Tyr Arg  Ile Arg His His Pro  Glu His Phe 
    1475                 1480                 1485             


Ser Gly  Arg Pro Arg Glu Asp  Arg Val Pro His Ser  Arg Asn Ser 
    1490                 1495                 1500             


Ile Thr  Leu Thr Asn Leu Thr  Pro Gly Thr Glu Tyr  Val Val Ser 
    1505                 1510                 1515             


Ile Val  Ala Leu Asn Gly Arg  Glu Glu Ser Pro Leu  Leu Ile Gly 
    1520                 1525                 1530             


Gln Gln  Ser Thr Val Ser Asp  Val Pro Arg Asp Leu  Glu Val Val 
    1535                 1540                 1545             


Ala Ala  Thr Pro Thr Ser Leu  Leu Ile Ser Trp Asp  Ala Pro Ala 
    1550                 1555                 1560             


Val Thr  Val Arg Tyr Tyr Arg  Ile Thr Tyr Gly Glu  Thr Gly Gly 
    1565                 1570                 1575             


Asn Ser  Pro Val Gln Glu Phe  Thr Val Pro Gly Ser  Lys Ser Thr 
    1580                 1585                 1590             


Ala Thr  Ile Ser Gly Leu Lys  Pro Gly Val Asp Tyr  Thr Ile Thr 
    1595                 1600                 1605             


Val Tyr  Ala Val Thr Gly Arg  Gly Asp Ser Pro Ala  Ser Ser Lys 
    1610                 1615                 1620             


Pro Ile  Ser Ile Asn Tyr Arg  Thr Glu Ile Asp Lys  Pro Ser Gln 
    1625                 1630                 1635             


Met Gln  Val Thr Asp Val Gln  Asp Asn Ser Ile Ser  Val Lys Trp 
    1640                 1645                 1650             


Leu Pro  Ser Ser Ser Pro Val  Thr Gly Tyr Arg Val  Thr Thr Thr 
    1655                 1660                 1665             


Pro Lys  Asn Gly Pro Gly Pro  Thr Lys Thr Lys Thr  Ala Gly Pro 
    1670                 1675                 1680             


Asp Gln  Thr Glu Met Thr Ile  Glu Gly Leu Gln Pro  Thr Val Glu 
    1685                 1690                 1695             


Tyr Val  Val Ser Val Tyr Ala  Gln Asn Pro Ser Gly  Glu Ser Gln 
    1700                 1705                 1710             


Pro Leu  Val Gln Thr Ala Val  Thr Asn Ile Asp Arg  Pro Lys Gly 
    1715                 1720                 1725             


Leu Ala  Phe Thr Asp Val Asp  Val Asp Ser Ile Lys  Ile Ala Trp 
    1730                 1735                 1740             


Glu Ser  Pro Gln Gly Gln Val  Ser Arg Tyr Arg Val  Thr Tyr Ser 
    1745                 1750                 1755             


Ser Pro  Glu Asp Gly Ile His  Glu Leu Phe Pro Ala  Pro Asp Gly 
    1760                 1765                 1770             


Glu Glu  Asp Thr Ala Glu Leu  Gln Gly Leu Arg Pro  Gly Ser Glu 
    1775                 1780                 1785             


Tyr Thr  Val Ser Val Val Ala  Leu His Asp Asp Met  Glu Ser Gln 
    1790                 1795                 1800             


Pro Leu  Ile Gly Thr Gln Ser  Thr Ala Ile Pro Ala  Pro Thr Asp 
    1805                 1810                 1815             


Leu Lys  Phe Thr Gln Val Thr  Pro Thr Ser Leu Ser  Ala Gln Trp 
    1820                 1825                 1830             


Thr Pro  Pro Asn Val Gln Leu  Thr Gly Tyr Arg Val  Arg Val Thr 
    1835                 1840                 1845             


Pro Lys  Glu Lys Thr Gly Pro  Met Lys Glu Ile Asn  Leu Ala Pro 
    1850                 1855                 1860             


Asp Ser  Ser Ser Val Val Val  Ser Gly Leu Met Val  Ala Thr Lys 
    1865                 1870                 1875             


Tyr Glu  Val Ser Val Tyr Ala  Leu Lys Asp Thr Leu  Thr Ser Arg 
    1880                 1885                 1890             


Pro Ala  Gln Gly Val Val Thr  Thr Leu Glu Asn Val  Ser Pro Pro 
    1895                 1900                 1905             


Arg Arg  Ala Arg Val Thr Asp  Ala Thr Glu Thr Thr  Ile Thr Ile 
    1910                 1915                 1920             


Ser Trp  Arg Thr Lys Thr Glu  Thr Ile Thr Gly Phe  Gln Val Asp 
    1925                 1930                 1935             


Ala Val  Pro Ala Asn Gly Gln  Thr Pro Ile Gln Arg  Thr Ile Lys 
    1940                 1945                 1950             


Pro Asp  Val Arg Ser Tyr Thr  Ile Thr Gly Leu Gln  Pro Gly Thr 
    1955                 1960                 1965             


Asp Tyr  Lys Ile Tyr Leu Tyr  Thr Leu Asn Asp Asn  Ala Arg Ser 
    1970                 1975                 1980             


Ser Pro  Val Val Ile Asp Ala  Ser Thr Ala Ile Asp  Ala Pro Ser 
    1985                 1990                 1995             


Asn Leu  Arg Phe Leu Ala Thr  Thr Pro Asn Ser Leu  Leu Val Ser 
    2000                 2005                 2010             


Trp Gln  Pro Pro Arg Ala Arg  Ile Thr Gly Tyr Ile  Ile Lys Tyr 
    2015                 2020                 2025             


Glu Lys  Pro Gly Ser Pro Pro  Arg Glu Val Val Pro  Arg Pro Arg 
    2030                 2035                 2040             


Pro Gly  Val Thr Glu Ala Thr  Ile Thr Gly Leu Glu  Pro Gly Thr 
    2045                 2050                 2055             


Glu Tyr  Thr Ile Tyr Val Ile  Ala Leu Lys Asn Asn  Gln Lys Ser 
    2060                 2065                 2070             


Glu Pro  Leu Ile Gly Arg Lys  Lys Thr Asp Glu Leu  Pro Gln Leu 
    2075                 2080                 2085             


Val Thr  Leu Pro His Pro Asn  Leu His Gly Pro Glu  Ile Leu Asp 
    2090                 2095                 2100             


Val Pro  Ser Thr Val Gln Lys  Thr Pro Phe Val Thr  His Pro Gly 
    2105                 2110                 2115             


Tyr Asp  Thr Gly Asn Gly Ile  Gln Leu Pro Gly Thr  Ser Gly Gln 
    2120                 2125                 2130             


Gln Pro  Ser Val Gly Gln Gln  Met Ile Phe Glu Glu  His Gly Phe 
    2135                 2140                 2145             


Arg Arg  Thr Thr Pro Pro Thr  Thr Ala Thr Pro Ile  Arg His Arg 
    2150                 2155                 2160             


Pro Arg  Pro Tyr Pro Pro Asn  Val Gly Glu Glu Ile  Gln Ile Gly 
    2165                 2170                 2175             


His Ile  Pro Arg Glu Asp Val  Asp Tyr His Leu Tyr  Pro His Gly 
    2180                 2185                 2190             


Pro Gly  Leu Asn Pro Asn Ala  Ser Thr Gly Gln Glu  Ala Leu Ser 
    2195                 2200                 2205             


Gln Thr  Thr Ile Ser Trp Ala  Pro Phe Gln Asp Thr  Ser Glu Tyr 
    2210                 2215                 2220             


Ile Ile  Ser Cys His Pro Val  Gly Thr Asp Glu Glu  Pro Leu Gln 
    2225                 2230                 2235             


Phe Arg  Val Pro Gly Thr Ser  Thr Ser Ala Thr Leu  Thr Gly Leu 
    2240                 2245                 2250             


Thr Arg  Gly Ala Thr Tyr Asn  Ile Ile Val Glu Ala  Leu Lys Asp 
    2255                 2260                 2265             


Gln Gln  Arg His Lys Val Arg  Glu Glu Val Val Thr  Val Gly Asn 
    2270                 2275                 2280             


Ser Val  Asn Glu Gly Leu Asn  Gln Pro Thr Asp Asp  Ser Cys Phe 
    2285                 2290                 2295             


Asp Pro  Tyr Thr Val Ser His  Tyr Ala Val Gly Asp  Glu Trp Glu 
    2300                 2305                 2310             


Arg Met  Ser Glu Ser Gly Phe  Lys Leu Leu Cys Gln  Cys Leu Gly 
    2315                 2320                 2325             


Phe Gly  Ser Gly His Phe Arg  Cys Asp Ser Ser Arg  Trp Cys His 
    2330                 2335                 2340             


Asp Asn  Gly Val Asn Tyr Lys  Ile Gly Glu Lys Trp  Asp Arg Gln 
    2345                 2350                 2355             


Gly Glu  Asn Gly Gln Met Met  Ser Cys Thr Cys Leu  Gly Asn Gly 
    2360                 2365                 2370             


Lys Gly  Glu Phe Lys Cys Asp  Pro His Glu Ala Thr  Cys Tyr Asp 
    2375                 2380                 2385             


Asp Gly  Lys Thr Tyr His Val  Gly Glu Gln Trp Gln  Lys Glu Tyr 
    2390                 2395                 2400             


Leu Gly  Ala Ile Cys Ser Cys  Thr Cys Phe Gly Gly  Gln Arg Gly 
    2405                 2410                 2415             


Trp Arg  Cys Asp Asn Cys Arg  Arg Pro Gly Gly Glu  Pro Ser Pro 
    2420                 2425                 2430             


Glu Gly  Thr Thr Gly Gln Ser  Tyr Asn Gln Tyr Ser  Gln Arg Tyr 
    2435                 2440                 2445             


His Gln  Arg Thr Asn Thr Asn  Val Asn Cys Pro Ile  Glu Cys Phe 
    2450                 2455                 2460             


Met Pro  Leu Asp Val Gln Ala  Asp Arg Glu Asp Ser  Arg Glu 
    2465                 2470                 2475         


