
                                SEQUENCE LISTING

<110> Novartis AG

<120> FXDY5 Modulators for Treating,
  Diagnosing, and Detecting Cancer
  

<130> 20366-135WO1

<150> US 60/908,580       
<151> 2007-03-28  

<160> 26

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 890
<212> DNA
<213> Homo sapiens

<400> 1
ctggccacac cctccgcctg gacgcagcag ccaccgccgc gtccctctct ccacgaggct 60
gccggcttag gacccccagc tccgacatgt cgccctctgg tcgcctgtgt cttctcacca 120
tcgttggcct gattctcccc accagaggac agacgttgaa agataccacg tccagttctt 180
cagcagactc aactatcatg gacattcagg tcccgacacg agccccagat gcagtctaca 240
cagaactcca gcccacctct ccaaccccaa cctggcctgc tgatgaaaca ccacaacccc 300
agacccagac ccagcaactg gaaggaacgg atgggcctct agtgacagat ccagagacac 360
acaagagcac caaagcagct catcccactg atgacaccac gacgctctct gagagaccat 420
ccccaagcac agacgtccag acagaccccc agaccctcaa gccatctggt tttcatgagg 480
atgacccctt cttctatgat gaacacaccc tccggaaacg ggggctgttg gtcgcagctg 540
tgctgttcat cacaggcatc atcatcctca ccagtggcaa gtgcaggcag ctgtcccggt 600
tatgccggaa tcgttgcagg tgagtccatc agaaacagga gctgacaacc tgctgggcac 660
ccgaagacca agccccctgc cagctcaccg tgcccagcct cctgcatccc ctcgaagagc 720
ctggccagag agggaagaca cagatgatga agctggagcc agggctgccg gtccgagtct 780
cctacctccc ccaaccctgc ccgcccctga aggctacctg gcgccttggg ggctgtccct 840
caagttatct cctctgctaa gacaaaaagt aaagcactgt ggtctttgcc            890

<210> 2
<211> 178
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Pro Ser Gly Arg Leu Cys Leu Leu Thr Ile Val Gly Leu Ile
 1               5                  10                  15      
Leu Pro Thr Arg Gly Gln Thr Leu Lys Asp Thr Thr Ser Ser Ser Ser
            20                  25                  30          
Ala Asp Ser Thr Ile Met Asp Ile Gln Val Pro Thr Arg Ala Pro Asp
        35                  40                  45              
Ala Val Tyr Thr Glu Leu Gln Pro Thr Ser Pro Thr Pro Thr Trp Pro
    50                  55                  60                  
Ala Asp Glu Thr Pro Gln Pro Gln Thr Gln Thr Gln Gln Leu Glu Gly
65                  70                  75                  80  
Thr Asp Gly Pro Leu Val Thr Asp Pro Glu Thr His Lys Ser Thr Lys
                85                  90                  95      
Ala Ala His Pro Thr Asp Asp Thr Thr Thr Leu Ser Glu Arg Pro Ser
            100                 105                 110         
Pro Ser Thr Asp Val Gln Thr Asp Pro Gln Thr Leu Lys Pro Ser Gly
        115                 120                 125             
Phe His Glu Asp Asp Pro Phe Phe Tyr Asp Glu His Thr Leu Arg Lys
    130                 135                 140                 
Arg Gly Leu Leu Val Ala Ala Val Leu Phe Ile Thr Gly Ile Ile Ile
145                 150                 155                 160 
Leu Thr Ser Gly Lys Cys Arg Gln Leu Ser Arg Leu Cys Arg Asn Arg
                165                 170                 175     
Cys Arg
        


<210> 3
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3
Thr Arg Gly Gln Thr Leu Lys Asp Thr Thr Ser Ser Ser Ser Ala
 1               5                  10                  15  


<210> 4
<211> 29
<212> PRT
<213> Homo sapiens

<400> 4
Leu Gln Pro Thr Ser Pro Thr Pro Thr Trp Pro Ala Asp Glu Thr Pro
 1               5                  10                  15      
Gln Pro Gln Thr Gln Thr Gln Gln Leu Glu Gly Thr Asp
            20                  25                  


<210> 5
<211> 9
<212> PRT
<213> Homo sapiens

<400> 5
Pro Glu Thr His Lys Ser Thr Lys Ala
 1               5                  


<210> 6
<211> 26
<212> PRT
<213> Homo sapiens

<400> 6
Pro Thr Asp Asp Thr Thr Thr Leu Ser Glu Arg Pro Ser Pro Ser Thr
 1               5                  10                  15      
Asp Val Gln Thr Asp Pro Gln Thr Leu Lys
            20                  25      


<210> 7
<211> 9
<212> PRT
<213> Homo sapiens

<400> 7
Ser Gly Phe His Glu Asp Asp Pro Phe
 1               5                  


<210> 8
<211> 537
<212> DNA
<213> Homo sapiens

<400> 8
atgtcgccct ctggtcgcct gtgtcttctc accatcgttg gcctgattct ccccaccaga 60
ggacagacgt tgaaagatac cacgtccagt tcttcagcag actcaactat catggacatt 120
caggtcccga cacgagcccc agatgcagtc tacacagaac tccagcccac ctctccaacc 180
ccaacctggc ctgctgatga aacaccacaa ccccagaccc agacccagca actggaagga 240
acggatgggc ctctagtgac agatccagag acacacaaga gcaccaaagc agctcatccc 300
actgatgaca ccacgacgct ctctgagaga ccatccccaa gcacagacgt ccagacagac 360
ccccagaccc tcaagccatc tggttttcat gaggatgacc ccttcttcta tgatgaacac 420
accctccgga aacgggggct gttggtcgca gctgtgctgt tcatcacagg catcatcatc 480
ctcaccagtg gcaagtgcag gcagctgtcc cggttatgcc ggaatcgttg caggtga    537

<210> 9
<211> 1631
<212> DNA
<213> Homo sapiens

<400> 9
ctggccacac cctccgcctg gacgcagcag ccaccgccgc gtccctctct ccacgaggct 60
gccggcttag gacccccagc tccgacgtaa gtccctctcg cgcgccacct ccatccgctg 120
cccctctgcc cacgggccgg gctcaggtgg gtaggggttt gaccccttcc gctcctctcc 180
gccccccatc cacgcccaca tctctctgcc tcctctcctg ggctacagtg ggccgctctg 240
cctcgctccc gcccgcctgc ctcagtctcc ccagctctct gccacccccc tcggaccagt 300
gcctcttagg tctctccagc gcgccatccc tgcaaggcgg cccctgacac caactcactt 360
tttcctctga gcgcgggagg cgttactcac tcttcctcct tcccctcctc gccgactccc 420
gggctctggg cccctggggg agggaagagg cctcctatct actcctctgc cccagtcccc 480
tccttgcgtc agtcccagtg agggataagc gcctggcgga aggcgcaggg aggtgtttct 540
ctgcttcagg agtgcccgcc ggcccttgca gctgctggaa gacccattta tctcatgctt 600
cttgttttct ttggggacct gcaggggaag gaagcagggt gacggtttgg tatccccacc 660
taagaccctc ccctttcccc tgaggccagc cgtcagcccc tggcaggggg tcttggaagc 720
cagaggtttt tgctcagggc agggaaaggg ctgcaggatc cccgggggct gccggaggtc 780
ggtctcactg acatcatggc tgaccccagc atcgcctggt cccacagatg tcgccctctg 840
gtcgcctgtg tcttctcacc atcgttggcc tgattctccc caccagagga cagacgttga 900
aagataccac gtccagttct tcagcagact caactatcat ggacattcag gtcccgacac 960
gagccccaga tgcagtctac acagaactcc agcccacctc tccaacccca acctggcctg 1020
ctgatgaaac accacaaccc cagacccaga cccagcaact ggaaggaacg gatgggcctc 1080
tagtgacaga tccagagaca cacaagagca ccaaagcagc tcatcccact gatgacacca 1140
cgacgctctc tgagagacca tccccaagca cagacgtcca gacagacccc cagaccctca 1200
agccatctgg ttttcatgag gatgacccct tcttctatga tgaacacacc ctccggaaac 1260
gggggctgtt ggtcgcagct gtgctgttca tcacaggcat catcatcctc accagtggca 1320
agtgcaggca gctgtcccgg ttatgccgga atcgttgcag gtgagtccat cagaaacagg 1380
agctgacaac ctgctgggca cccgaagacc aagccccctg ccagctcacc gtgcccagcc 1440
tcctgcatcc cctcgaagag cctggccaga gagggaagac acagatgatg aagctggagc 1500
cagggctgcc ggtccgagtc tcctacctcc cccaaccctg cccgcccctg aaggctacct 1560
ggcgccttgg gggctgtccc tcaagttatc tcctctgcta agacaaaaag taaagcactg 1620
tggtctttgc c                                                      1631

<210> 10
<211> 145
<212> PRT
<213> Homo sapiens

<400> 10
Met Ser Pro Ser Gly Arg Leu Cys Leu Leu Thr Ile Val Gly Leu Ile
 1               5                  10                  15      
Leu Pro Thr Arg Gly Gln Thr Leu Lys Asp Thr Thr Ser Ser Ser Ser
            20                  25                  30          
Ala Asp Ser Thr Ile Met Asp Ile Gln Val Pro Thr Arg Ala Pro Asp
        35                  40                  45              
Ala Val Tyr Thr Glu Leu Gln Pro Thr Ser Pro Thr Pro Thr Trp Pro
    50                  55                  60                  
Ala Asp Glu Thr Pro Gln Pro Gln Thr Gln Thr Gln Gln Leu Glu Gly
65                  70                  75                  80  
Thr Asp Gly Pro Leu Val Thr Asp Pro Glu Thr His Lys Ser Thr Lys
                85                  90                  95      
Ala Ala His Pro Thr Asp Asp Thr Thr Thr Leu Ser Glu Arg Pro Ser
            100                 105                 110         
Pro Ser Thr Asp Val Gln Thr Asp Pro Gln Thr Leu Lys Pro Ser Gly
        115                 120                 125             
Phe His Glu Asp Asp Pro Phe Phe Tyr Asp Glu His Thr Leu Arg Lys
    130                 135                 140                 
Arg
145 


<210> 11
<211> 21
<212> PRT
<213> Homo sapiens

<400> 11
Met Ser Pro Ser Gly Arg Leu Cys Leu Leu Thr Ile Val Gly Leu Ile
 1               5                  10                  15      
Leu Pro Thr Arg Gly
            20      


<210> 12
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 12
ggtgagaaga cacaggcgac caga                                        24

<210> 13
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 13
ttgagtctgc tgaagaactg gacgt                                       25

<210> 14
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 14
gtgtcgggac ctgaatgtcc atgat                                       25

<210> 15
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 15
gagaggtggg ctggagttct gtgta                                       25

<210> 16
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 16
atccgttcct tccagttgct gggt                                        24

<210> 17
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 17
gcgtcgtggt gtcatcagtg ggat                                        24

<210> 18
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 18
ggatgatgat gcctgtgatg aacag                                       25

<210> 19
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 19
tgatggactc acctgcaacg attcc                                       25

<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 20
cccggttatg ccggaatcgt t                                           21

<210> 21
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 21
ctcaactatc atggacattc a                                           21

<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 22
gaggacagac gttgaaagat a                                           21

<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 23
ccagatgcag tctacacaga a                                           21

<210> 24
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 24
caggcatcat catcctcacc a                                           21

<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 25
caggtgagtc catcagaaac a                                           21

<210> 26
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 26
gagggaagac acagatgatg a                                           21






