
                                SEQUENCE LISTING

<110> ZymoGenetics, Inc.
      Levin, Steven D.
      Rixon, Mark W.
      Gao, Zeren

<120> SOLUBLE IL-17RA/RC FUSION PROTEINS AND
  RELATED METHODS

<130> 07-06PC

<150> 11/691,000
<151> 2007-03-26

<150> 60/908,554          
<151> 2007-03-28  

<150> 60/983,822          
<151> 2007-10-30  

<160> 190

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2255
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (154)...(2229)

<220> 
<223> Optimized tissue Plasminogen Activator (otPA)
      pre-pro signal sequence and exons 7-10 of human
      IL-17RC, and Fc5
      

<400> 1
aactacccag cacagccccc tccgccccct ctggaggctg aagagggatt ccagcccctg 60
ccacccacag acacgggctg actggggtgt ctgcccccct tggggggggg cagcacaggg 120
cctcaggcct gggtgccacc tggcacctag aag atg cct gtg ccc tgg ttc ttg  174
                                     Met Pro Val Pro Trp Phe Leu
                                      1               5
 
ctg tcc ttg gca ctg ggc cga agc cca gtg gtc ctt tct ctg gag agg   222
Leu Ser Leu Ala Leu Gly Arg Ser Pro Val Val Leu Ser Leu Glu Arg
         10                  15                  20
 
ctt gtg ggg cct cag gac gct acc cac tgc tct ccg ggc ctc tcc tgc   270
Leu Val Gly Pro Gln Asp Ala Thr His Cys Ser Pro Gly Leu Ser Cys
     25                  30                  35
 
cgc ctc tgg gac agt gac ata ctc tgc ctg cct ggg gac atc gtg cct   318
Arg Leu Trp Asp Ser Asp Ile Leu Cys Leu Pro Gly Asp Ile Val Pro
 40                  45                  50                  55
 
gct ccg ggc ccc gtg ctg gcg cct acg cac ctg cag aca gag ctg gtg   366
Ala Pro Gly Pro Val Leu Ala Pro Thr His Leu Gln Thr Glu Leu Val
                 60                  65                  70
 
ctg agg tgc cag aag gag acc gac tgt gac ctc tgt ctg cgt gtg gct   414
Leu Arg Cys Gln Lys Glu Thr Asp Cys Asp Leu Cys Leu Arg Val Ala
             75                  80                  85
 
gtc cac ttg gcc gtg cat ggg cac tgg gaa gag cct gaa gat gag gaa   462
Val His Leu Ala Val His Gly His Trp Glu Glu Pro Glu Asp Glu Glu
         90                  95                 100
 
aag ttt gga gga gca gct gac tca ggg gtg gag gag cct agg aat gcc   510
Lys Phe Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro Arg Asn Ala
    105                 110                 115
 
tct ctc cag gcc caa gtc gtg ctc tcc ttc cag gcc tac cct act gcc   558
Ser Leu Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala
120                 125                 130                 135
 
cgc tgc gtc ctg ctg gag gtg caa gtg cct gct gcc ctt gtg cag ttt   606
Arg Cys Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe
                140                 145                 150
 
ggt cag tct gtg ggc tct gtg gta tat gac tgc ttc gag gct gcc cta   654
Gly Gln Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu
            155                 160                 165
 
ggg agt gag gta cga atc tgg tcc tat act cag ccc agg tac gag aag   702
Gly Ser Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys
        170                 175                 180
 
gaa ctc aac cac aca cag cag ctg cct gcc ctg ccc tgg ctc aac gtg   750
Glu Leu Asn His Thr Gln Gln Leu Pro Ala Leu Pro Trp Leu Asn Val
    185                 190                 195
 
tca gca gat ggt gac aac gtg cat ctg gtt ctg aat gtc tct gag gag   798
Ser Ala Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu
200                 205                 210                 215
 
cag cac ttc ggc ctc tcc ctg tac tgg aat cag gtc cag ggc ccc cca   846
Gln His Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro
                220                 225                 230
 
aaa ccc cgg tgg cac aaa aac ctg act gga ccg cag atc att acc ttg   894
Lys Pro Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu
            235                 240                 245
 
aac cac aca gac ctg gtt ccc tgc ctc tgt att cag gtg tgg cct ctg   942
Asn His Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu
        250                 255                 260
 
gaa cct gac tcc gtt agg acg aac atc tgc ccc ttc agg gag gac ccc   990
Glu Pro Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro
    265                 270                 275
 
cgc gca cac cag aac ctc tgg caa gcc gcc cga ctg cga ctg ctg acc   1038
Arg Ala His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr
280                 285                 290                 295
 
ctg cag agc tgg ctg ctg gac gca ccg tgc tcg ctg ccc gca gaa gcg   1086
Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala
                300                 305                 310
 
gca ctg tgc tgg cgg gct ccg ggt ggg gac ccc tgc cag cca ctg gtc   1134
Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val
            315                 320                 325
 
cca ccg ctt tcc tgg gag aac gtc act gtg gac aag gtt ctc gag ttc   1182
Pro Pro Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe
        330                 335                 340
 
cca ttg ctg aaa ggc cac cct aac ctc tgt gtt cag gtg aac agc tcg   1230
Pro Leu Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser
    345                 350                 355
 
gag aag ctg cag ctg cag gag tgc ttg tgg gct gac tcc ctg ggg cct   1278
Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro
360                 365                 370                 375
 
ctc aaa gac gat gtg cta ctg ttg gag aca cga ggc ccc cag gac aac   1326
Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn
                380                 385                 390
 
aga tcc ctc tgt gcc ttg gaa ccc agt ggc tgt act tca cta ccc agc   1374
Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser
            395                 400                 405
 
aaa gcc tcc acg agg gca gct cgc ctt gga gag tac tta cta caa gac   1422
Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp
        410                 415                 420
 
ctg cag tca ggc cag tgt ctg cag cta tgg gac gat gac ttg gga gcg   1470
Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala
    425                 430                 435
 
cta tgg gcc tgc ccc atg gac aaa tac atc cac aag cgc tgg gcc ctc   1518
Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Lys Arg Trp Ala Leu
440                 445                 450                 455
 
gtg tgg ctg gcc tgc cta ctc ttt gcc gct gcg ctt tcc ctc atc ctc   1566
Val Trp Leu Ala Cys Leu Leu Phe Ala Ala Ala Leu Ser Leu Ile Leu
                460                 465                 470
 
ctt ctc aaa aag gat cac gcg aaa gcg gcc gcc agg ggc cgc gcg gct   1614
Leu Leu Lys Lys Asp His Ala Lys Ala Ala Ala Arg Gly Arg Ala Ala
            475                 480                 485
 
ctg ctc ctc tac tca gcc gat gac tcg ggt ttc gag cgc ctg gtg ggc   1662
Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu Arg Leu Val Gly
        490                 495                 500
 
gcc ctg gcg tcg gcc ctg tgc cag ctg ccg ctg cgc gtg gcc gta gac   1710
Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg Val Ala Val Asp
    505                 510                 515
 
ctg tgg agc cgt cgt gaa ctg agc gcg cag ggg ccc gtg gct tgg ttt   1758
Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro Val Ala Trp Phe
520                 525                 530                 535
 
cac gcg cag cgg cgc cag acc ctg cag gag ggc ggc gtg gtg gtc ttg   1806
His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly Val Val Val Leu
                540                 545                 550
 
ctc ttc tct ccc ggt gcg gtg gcg ctg tgc agc gag tgg cta cag gat   1854
Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu Trp Leu Gln Asp
            555                 560                 565
 
ggg gtg tcc ggg ccc ggg gcg cac ggc ccg cac gac gcc ttc cgc gcc   1902
Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp Ala Phe Arg Ala
        570                 575                 580
 
tcg ctc agc tgc gtg ctg ccc gac ttc ttg cag ggc cgg gcg ccc ggc   1950
Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg Ala Pro Gly
    585                 590                 595
 
agc tac gtg ggg gcc tgc ttc gac agg ctg ctc cac ccg gac gcc gta   1998
Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His Pro Asp Ala Val
600                 605                 610                 615
 
ccc gcc ctt ttc cgc acc gtg ccc gtc ttc aca ctg ccc tcc caa ctg   2046
Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu Pro Ser Gln Leu
                620                 625                 630
 
cca gac ttc ctg ggg gcc ctg cag cag cct cgc gcc ccg cgt tcc ggg   2094
Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala Pro Arg Ser Gly
            635                 640                 645
 
cgg ctc caa gag aga gcg gag caa gtg tcc cgg gcc ctt cag cca gcc   2142
Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala Leu Gln Pro Ala
        650                 655                 660
 
ctg gat agc tac ttc cat ccc ccg ggg act ccc gcg ccg gga cgc ggg   2190
Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala Pro Gly Arg Gly
    665                 670                 675
 
gtg gga cca ggg gcg gga cct ggg gcg ggg gac ggg act taaataaagg    2239
Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly Thr
680                 685                 690
 
cagacgctgt ttttct                                                 2255

<210> 2
<211> 692
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu
        195                 200                 205             
Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp
    210                 215                 220                 
Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr
225                 230                 235                 240 
Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu
                245                 250                 255     
Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile
            260                 265                 270         
Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala
        275                 280                 285             
Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro
    290                 295                 300                 
Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly
305                 310                 315                 320 
Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr
                325                 330                 335     
Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu
            340                 345                 350         
Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu
        355                 360                 365             
Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu
    370                 375                 380                 
Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser
385                 390                 395                 400 
Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu
                405                 410                 415     
Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu
            420                 425                 430         
Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr
        435                 440                 445             
Ile His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala
    450                 455                 460                 
Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Ala
465                 470                 475                 480 
Ala Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser
                485                 490                 495     
Gly Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu
            500                 505                 510         
Pro Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala
        515                 520                 525             
Gln Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln
    530                 535                 540                 
Glu Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu
545                 550                 555                 560 
Cys Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly
                565                 570                 575     
Pro His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe
            580                 585                 590         
Leu Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg
        595                 600                 605             
Leu Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val
    610                 615                 620                 
Phe Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln
625                 630                 635                 640 
Pro Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val
                645                 650                 655     
Ser Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly
            660                 665                 670         
Thr Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala
        675                 680                 685             
Gly Asp Gly Thr
    690         


<210> 3
<211> 432
<212> PRT
<213> Homo sapiens

<400> 3
Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His Cys Ser Pro Gly
 1               5                  10                  15      
Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys Leu Pro Gly Asp
            20                  25                  30          
Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr His Leu Gln Thr
        35                  40                  45              
Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys Asp Leu Cys Leu
    50                  55                  60                  
Arg Val Ala Val His Leu Ala Val His Gly His Trp Glu Glu Pro Glu
65                  70                  75                  80  
Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro
                85                  90                  95      
Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr
            100                 105                 110         
Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu
        115                 120                 125             
Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu
    130                 135                 140                 
Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg
145                 150                 155                 160 
Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro Ala Leu Pro Trp
                165                 170                 175     
Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val Leu Asn Val
            180                 185                 190         
Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln
        195                 200                 205             
Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile
    210                 215                 220                 
Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val
225                 230                 235                 240 
Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg
                245                 250                 255     
Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg
            260                 265                 270         
Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro
        275                 280                 285             
Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln
    290                 295                 300                 
Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val
305                 310                 315                 320 
Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys Val Gln Val
                325                 330                 335     
Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser
            340                 345                 350         
Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro
        355                 360                 365             
Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser
    370                 375                 380                 
Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu
385                 390                 395                 400 
Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp
                405                 410                 415     
Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Lys Arg
            420                 425                 430         


<210> 4
<211> 1753
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (2)...(1726)

<400> 4
g gag gag cct agg aat gcc tct ctc cag gcc caa gtc gtg ctc tcc ttc 49
  Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe
   1               5                   10                  15
 
cag gcc tac cct act gcc cgc tgc gtc ctg ctg gag gtg caa gtg cct   97
Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val Pro
             20                  25                  30
 
gct gcc ctt gtg cag ttt ggt cag tct gtg ggc tct gtg gta tat gac   145
Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr Asp
         35                  40                  45
 
tgc ttc gag gct gcc cta ggg agt gag gta cga atc tgg tcc tat act   193
Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr Thr
     50                  55                  60
 
cag ccc agg tac gag aag gaa ctc aac cac aca cag cag ctg cct gcc   241
Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro Ala
 65                  70                  75                  80
 
ctg ccc tgg ctc aac gtg tca gca gat ggt gac aac gtg cat ctg gtt   289
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
                 85                  90                  95
 
ctg aat gtc tct gag gag cag cac ttc ggc ctc tcc ctg tac tgg aat   337
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
            100                 105                 110
 
cag gtc cag ggc ccc cca aaa ccc cgg tgg cac aaa aac ctg act gga   385
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
        115                 120                 125
 
ccg cag atc att acc ttg aac cac aca gac ctg gtt ccc tgc ctc tgt   433
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
    130                 135                 140
 
att cag gtg tgg cct ctg gaa cct gac tcc gtt agg acg aac atc tgc   481
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
145                 150                 155                 160
 
ccc ttc agg gag gac ccc cgc gca cac cag aac ctc tgg caa gcc gcc   529
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
                165                 170                 175
 
cga ctg cga ctg ctg acc ctg cag agc tgg ctg ctg gac gca ccg tgc   577
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
            180                 185                 190
 
tcg ctg ccc gca gaa gcg gca ctg tgc tgg cgg gct ccg ggt ggg gac   625
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
        195                 200                 205
 
ccc tgc cag cca ctg gtc cca ccg ctt tcc tgg gag aac gtc act gtg   673
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
    210                 215                 220
 
gac gtg aac agc tcg gag aag ctg cag ctg cag gag tgc ttg tgg gct   721
Asp Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala
225                 230                 235                 240
 
gac tcc ctg ggg cct ctc aaa gac gat gtg cta ctg ttg gag aca cga   769
Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg
                245                 250                 255
 
ggc ccc cag gac aac aga tcc ctc tgt gcc ttg gaa ccc agt ggc tgt   817
Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys
            260                 265                 270
 
act tca cta ccc agc aaa gcc tcc acg agg gca gct cgc ctt gga gag   865
Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu
        275                 280                 285
 
tac tta cta caa gac ctg cag tca ggc cag tgt ctg cag cta tgg gac   913
Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp
    290                 295                 300
 
gat gac ttg gga gcg cta tgg gcc tgc ccc atg gac aaa tac atc cac   961
Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His
305                 310                 315                 320
 
aag cgc tgg gcc ctc gtg tgg ctg gcc tgc cta ctc ttt gcc gct gcg   1009
Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala Ala
                325                 330                 335
 
ctt tcc ctc atc ctc ctt ctc aaa aag gat cac gcg aaa ggg tgg ctg   1057
Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly Trp Leu
            340                 345                 350
 
agg ctc ttg aaa cag gac gtc cgc tcg ggg gcg gcc gcc agg ggc cgc   1105
Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg Gly Arg
        355                 360                 365
 
gcg gct ctg ctc ctc tac tca gcc gat gac tcg ggt ttc gag cgc ctg   1153
Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu Arg Leu
    370                 375                 380
 
gtg ggc gcc ctg gcg tcg gcc ctg tgc cag ctg ccg ctg cgc gtg gcc   1201
Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg Val Ala
385                 390                 395                 400
 
gta gac ctg tgg agc cgt cgt gaa ctg agc gcg cag ggg ccc gtg gct   1249
Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro Val Ala
                405                 410                 415
 
tgg ttt cac gcg cag cgg cgc cag acc ctg cag gag ggc ggc gtg gtg   1297
Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly Val Val
            420                 425                 430
 
gtc ttg ctc ttc tct ccc ggt gcg gtg gcg ctg tgc agc gag tgg cta   1345
Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu Trp Leu
        435                 440                 445
 
cag gat ggg gtg tcc ggg ccc ggg gcg cac ggc ccg cac gac gcc ttc   1393
Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp Ala Phe
    450                 455                 460
 
cgc gcc tcg ctc agc tgc gtg ctg ccc gac ttc ttg cag ggc cgg gcg   1441
Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg Ala
465                 470                 475                 480
 
ccc ggc agc tac gtg ggg gcc tgc ttc gac agg ctg ctc cac ccg gac   1489
Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His Pro Asp
                485                 490                 495
 
gcc gta ccc gcc ctt ttc cgc acc gtg ccc gtc ttc aca ctg ccc tcc   1537
Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu Pro Ser
            500                 505                 510
 
caa ctg cca gac ttc ctg ggg gcc ctg cag cag cct cgc gcc ccg cgt   1585
Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala Pro Arg
        515                 520                 525
 
tcc ggg cgg ctc caa gag aga gcg gag caa gtg tcc cgg gcc ctt cag   1633
Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala Leu Gln
    530                 535                 540
 
cca gcc ctg gat agc tac ttc cat ccc ccg ggg act ccc gcg ccg gga   1681
Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala Pro Gly
545                 550                 555                 560
 
cgc ggg gtg gga cca ggg gcg gga cct ggg gcg ggg gac ggg act       1726
Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly Thr
                565                 570                 575
 
taaataaagg cagacgctgt ttttcta                                     1753

<210> 5
<211> 575
<212> PRT
<213> Homo sapiens

<400> 5
Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe
 1               5                  10                  15      
Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val Pro
            20                  25                  30          
Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr Asp
        35                  40                  45              
Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr Thr
    50                  55                  60                  
Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro Ala
65                  70                  75                  80  
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
                85                  90                  95      
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
            100                 105                 110         
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
        115                 120                 125             
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
    130                 135                 140                 
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
145                 150                 155                 160 
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
                165                 170                 175     
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
            180                 185                 190         
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
        195                 200                 205             
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
    210                 215                 220                 
Asp Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala
225                 230                 235                 240 
Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg
                245                 250                 255     
Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys
            260                 265                 270         
Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu
        275                 280                 285             
Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp
    290                 295                 300                 
Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His
305                 310                 315                 320 
Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala Ala
                325                 330                 335     
Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly Trp Leu
            340                 345                 350         
Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg Gly Arg
        355                 360                 365             
Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu Arg Leu
    370                 375                 380                 
Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg Val Ala
385                 390                 395                 400 
Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro Val Ala
                405                 410                 415     
Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly Val Val
            420                 425                 430         
Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu Trp Leu
        435                 440                 445             
Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp Ala Phe
    450                 455                 460                 
Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg Ala
465                 470                 475                 480 
Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His Pro Asp
                485                 490                 495     
Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu Pro Ser
            500                 505                 510         
Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala Pro Arg
        515                 520                 525             
Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala Leu Gln
    530                 535                 540                 
Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala Pro Gly
545                 550                 555                 560 
Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly Thr
                565                 570                 575 


<210> 6
<211> 1725
<212> DNA
<213> Artificial Sequence

<220> 
<223> degenerate sequence

<220> 
<221> misc_feature   
<222> (1)...(1725)
<223> n = A,T,C or G

<400> 6
gargarccnm gnaaygcnws nytncargcn cargtngtny tnwsnttyca rgcntayccn 60
acngcnmgnt gygtnytnyt ngargtncar gtnccngcng cnytngtnca rttyggncar 120
wsngtnggnw sngtngtnta ygaytgytty gargcngcny tnggnwsnga rgtnmgnath 180
tggwsntaya cncarccnmg ntaygaraar garytnaayc ayacncarca rytnccngcn 240
ytnccntggy tnaaygtnws ngcngayggn gayaaygtnc ayytngtnyt naaygtnwsn 300
gargarcarc ayttyggnyt nwsnytntay tggaaycarg tncarggncc nccnaarccn 360
mgntggcaya araayytnac nggnccncar athathacny tnaaycayac ngayytngtn 420
ccntgyytnt gyathcargt ntggccnytn garccngayw sngtnmgnac naayathtgy 480
ccnttymgng argayccnmg ngcncaycar aayytntggc argcngcnmg nytnmgnytn 540
ytnacnytnc arwsntggyt nytngaygcn ccntgywsny tnccngcnga rgcngcnytn 600
tgytggmgng cnccnggngg ngayccntgy carccnytng tnccnccnyt nwsntgggar 660
aaygtnacng tngaygtnaa ywsnwsngar aarytncary tncargartg yytntgggcn 720
gaywsnytng gnccnytnaa rgaygaygtn ytnytnytng aracnmgngg nccncargay 780
aaymgnwsny tntgygcnyt ngarccnwsn ggntgyacnw snytnccnws naargcnwsn 840
acnmgngcng cnmgnytngg ngartayytn ytncargayy tncarwsngg ncartgyytn 900
carytntggg aygaygayyt nggngcnytn tgggcntgyc cnatggayaa rtayathcay 960
aarmgntggg cnytngtntg gytngcntgy ytnytnttyg cngcngcnyt nwsnytnath 1020
ytnytnytna araargayca ygcnaarggn tggytnmgny tnytnaarca rgaygtnmgn 1080
wsnggngcng cngcnmgngg nmgngcngcn ytnytnytnt aywsngcnga ygaywsnggn 1140
ttygarmgny tngtnggngc nytngcnwsn gcnytntgyc arytnccnyt nmgngtngcn 1200
gtngayytnt ggwsnmgnmg ngarytnwsn gcncarggnc cngtngcntg gttycaygcn 1260
carmgnmgnc aracnytnca rgarggnggn gtngtngtny tnytnttyws nccnggngcn 1320
gtngcnytnt gywsngartg gytncargay ggngtnwsng gnccnggngc ncayggnccn 1380
caygaygcnt tymgngcnws nytnwsntgy gtnytnccng ayttyytnca rggnmgngcn 1440
ccnggnwsnt aygtnggngc ntgyttygay mgnytnytnc ayccngaygc ngtnccngcn 1500
ytnttymgna cngtnccngt nttyacnytn ccnwsncary tnccngaytt yytnggngcn 1560
ytncarcarc cnmgngcncc nmgnwsnggn mgnytncarg armgngcnga rcargtnwsn 1620
mgngcnytnc arccngcnyt ngaywsntay ttycayccnc cnggnacncc ngcnccnggn 1680
mgnggngtng gnccnggngc nggnccnggn gcnggngayg gnacn                 1725

<210> 7
<211> 2076
<212> DNA
<213> Artificial Sequence

<220> 
<223> degenerate sequence

<220> 
<221> misc_feature   
<222> (1)...(2076)
<223> n = A,T,C or G

<400> 7
atgccngtnc cntggttyyt nytnwsnytn gcnytnggnm gnwsnccngt ngtnytnwsn 60
ytngarmgny tngtnggncc ncargaygcn acncaytgyw snccnggnyt nwsntgymgn 120
ytntgggayw sngayathyt ntgyytnccn ggngayathg tnccngcncc nggnccngtn 180
ytngcnccna cncayytnca racngarytn gtnytnmgnt gycaraarga racngaytgy 240
gayytntgyy tnmgngtngc ngtncayytn gcngtncayg gncaytggga rgarccngar 300
gaygargara arttyggngg ngcngcngay wsnggngtng argarccnmg naaygcnwsn 360
ytncargcnc argtngtnyt nwsnttycar gcntayccna cngcnmgntg ygtnytnytn 420
gargtncarg tnccngcngc nytngtncar ttyggncarw sngtnggnws ngtngtntay 480
gaytgyttyg argcngcnyt nggnwsngar gtnmgnatht ggwsntayac ncarccnmgn 540
taygaraarg arytnaayca yacncarcar ytnccngcny tnccntggyt naaygtnwsn 600
gcngayggng ayaaygtnca yytngtnytn aaygtnwsng argarcarca yttyggnytn 660
wsnytntayt ggaaycargt ncarggnccn ccnaarccnm gntggcayaa raayytnacn 720
ggnccncara thathacnyt naaycayacn gayytngtnc cntgyytntg yathcargtn 780
tggccnytng arccngayws ngtnmgnacn aayathtgyc cnttymgnga rgayccnmgn 840
gcncaycara ayytntggca rgcngcnmgn ytnmgnytny tnacnytnca rwsntggytn 900
ytngaygcnc cntgywsnyt nccngcngar gcngcnytnt gytggmgngc nccnggnggn 960
gayccntgyc arccnytngt nccnccnytn wsntgggara aygtnacngt ngayaargtn 1020
ytngarttyc cnytnytnaa rggncayccn aayytntgyg tncargtnaa ywsnwsngar 1080
aarytncary tncargartg yytntgggcn gaywsnytng gnccnytnaa rgaygaygtn 1140
ytnytnytng aracnmgngg nccncargay aaymgnwsny tntgygcnyt ngarccnwsn 1200
ggntgyacnw snytnccnws naargcnwsn acnmgngcng cnmgnytngg ngartayytn 1260
ytncargayy tncarwsngg ncartgyytn carytntggg aygaygayyt nggngcnytn 1320
tgggcntgyc cnatggayaa rtayathcay aarmgntggg cnytngtntg gytngcntgy 1380
ytnytnttyg cngcngcnyt nwsnytnath ytnytnytna araargayca ygcnaargcn 1440
gcngcnmgng gnmgngcngc nytnytnytn taywsngcng aygaywsngg nttygarmgn 1500
ytngtnggng cnytngcnws ngcnytntgy carytnccny tnmgngtngc ngtngayytn 1560
tggwsnmgnm gngarytnws ngcncarggn ccngtngcnt ggttycaygc ncarmgnmgn 1620
caracnytnc argarggngg ngtngtngtn ytnytnttyw snccnggngc ngtngcnytn 1680
tgywsngart ggytncarga yggngtnwsn ggnccnggng cncayggncc ncaygaygcn 1740
ttymgngcnw snytnwsntg ygtnytnccn gayttyytnc arggnmgngc nccnggnwsn 1800
taygtnggng cntgyttyga ymgnytnytn cayccngayg cngtnccngc nytnttymgn 1860
acngtnccng tnttyacnyt nccnwsncar ytnccngayt tyytnggngc nytncarcar 1920
ccnmgngcnc cnmgnwsngg nmgnytncar garmgngcng arcargtnws nmgngcnytn 1980
carccngcny tngaywsnta yttycayccn ccnggnacnc cngcnccngg nmgnggngtn 2040
ggnccnggng cnggnccngg ngcnggngay ggnacn                           2076

<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer

<400> 8
cggcgtggtg gtcttgctct t                                           21

<210> 9
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide linker

<400> 9
Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15      


<210> 10
<211> 688
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric Zcytor14 protein

<400> 10
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu
        195                 200                 205             
Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp
    210                 215                 220                 
Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr
225                 230                 235                 240 
Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu
                245                 250                 255     
Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile
            260                 265                 270         
Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala
        275                 280                 285             
Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro
    290                 295                 300                 
Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly
305                 310                 315                 320 
Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr
                325                 330                 335     
Val Asp Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp
            340                 345                 350         
Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr
        355                 360                 365             
Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly
    370                 375                 380                 
Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly
385                 390                 395                 400 
Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp
                405                 410                 415     
Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile
            420                 425                 430         
His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala
        435                 440                 445             
Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly Trp
    450                 455                 460                 
Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg Gly
465                 470                 475                 480 
Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu Arg
                485                 490                 495     
Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg Val
            500                 505                 510         
Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro Val
        515                 520                 525             
Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly Val
    530                 535                 540                 
Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu Trp
545                 550                 555                 560 
Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp Ala
                565                 570                 575     
Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg
            580                 585                 590         
Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His Pro
        595                 600                 605             
Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu Pro
    610                 615                 620                 
Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala Pro
625                 630                 635                 640 
Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala Leu
                645                 650                 655     
Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala Pro
            660                 665                 670         
Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly Thr
        675                 680                 685             


<210> 11
<211> 705
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric Zcytor14 protein

<400> 11
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu
        195                 200                 205             
Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp
    210                 215                 220                 
Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr
225                 230                 235                 240 
Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu
                245                 250                 255     
Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile
            260                 265                 270         
Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala
        275                 280                 285             
Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro
    290                 295                 300                 
Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly
305                 310                 315                 320 
Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr
                325                 330                 335     
Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu
            340                 345                 350         
Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu
        355                 360                 365             
Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu
    370                 375                 380                 
Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser
385                 390                 395                 400 
Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu
                405                 410                 415     
Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu
            420                 425                 430         
Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr
        435                 440                 445             
Ile His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala
    450                 455                 460                 
Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly
465                 470                 475                 480 
Trp Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg
                485                 490                 495     
Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu
            500                 505                 510         
Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg
        515                 520                 525             
Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro
    530                 535                 540                 
Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly
545                 550                 555                 560 
Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu
                565                 570                 575     
Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp
            580                 585                 590         
Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly
        595                 600                 605             
Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His
    610                 615                 620                 
Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu
625                 630                 635                 640 
Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala
                645                 650                 655     
Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala
            660                 665                 670         
Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala
        675                 680                 685             
Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly
    690                 695                 700                 
Thr
705 


<210> 12
<211> 675
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric Zcytor14 protein

<400> 12
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu
        195                 200                 205             
Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp
    210                 215                 220                 
Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr
225                 230                 235                 240 
Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu
                245                 250                 255     
Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile
            260                 265                 270         
Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala
        275                 280                 285             
Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro
    290                 295                 300                 
Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly
305                 310                 315                 320 
Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr
                325                 330                 335     
Val Asp Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp
            340                 345                 350         
Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr
        355                 360                 365             
Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly
    370                 375                 380                 
Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly
385                 390                 395                 400 
Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp
                405                 410                 415     
Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile
            420                 425                 430         
His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala
        435                 440                 445             
Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Ala Ala
    450                 455                 460                 
Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly
465                 470                 475                 480 
Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro
                485                 490                 495     
Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln
            500                 505                 510         
Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu
        515                 520                 525             
Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys
    530                 535                 540                 
Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro
545                 550                 555                 560 
His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu
                565                 570                 575     
Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu
            580                 585                 590         
Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe
        595                 600                 605             
Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro
    610                 615                 620                 
Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser
625                 630                 635                 640 
Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr
                645                 650                 655     
Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly
            660                 665                 670         
Asp Gly Thr
        675 


<210> 13
<211> 1874
<212> DNA
<213> Homo sapiens

<400> 13
gaattccggc aggcacaaac tcatccatcc ccagttgatt ggaagaaaca acgatgactc 60
ctgggaagac ctcattggtg tcactgctac tgctgctgag cctggaggcc atagtgaagg 120
caggaatcac aatcccacga aatccaggat gcccaaattc tgaggacaag aacttccccc 180
ggactgtgat ggtcaacctg aacatccata accggaatac caataccaat cccaaaaggt 240
cctcagatta ctacaaccga tccacctcac cttggaatct ccaccgcaat gaggaccctg 300
agagatatcc ctctgtgatc tgggaggcaa agtgccgcca cttgggctgc atcaacgctg 360
atgggaacgt ggactaccac atgaactctg tccccatcca gcaagagatc ctggtcctgc 420
gcagggagcc tccacactgc cccaactcct tccggctgga gaagatactg gtgtccgtgg 480
gctgcacctg tgtcaccccg attgtccacc atgtggccta agagctctgg ggagcccaca 540
ctccccaaag cagttagact atggagagcc gacccagccc ctcaggaacc ctcatccttc 600
aaagacagcc tcatttcgga ctaaactcat tagagttctt aaggcagttt gtccaattaa 660
agcttcagag gtaacacttg gccaagatat gagatctgaa ttacctttcc ctctttccaa 720
gaaggaaggt ttgactgagt accaatttgc ttcttgttta cttttttaag ggctttaagt 780
tatttatgta tttaatatgc cctgagataa ctttggggta taagattcca ttttaatgaa 840
ttacctactt tattttgttt gtctttttaa agaagataag attctgggct tgggaatttt 900
attatttaaa aggtaaaacc tgtatttatt tgagctattt aaggatctat ttatgtttaa 960
gtatttagaa aaaggtgaaa aagcactatt atcagttctg cctaggtaaa tgtaagatag 1020
aattaaatgg cagtgcaaaa tttctgagtc tttacaacat acggatatag tatttcctcc 1080
tctttgtttt taaaagttat aacatggctg aaaagaaaga ttaaacctac tttcatatgt 1140
attaatttaa attttgcaat ttgttgaggt tttacaagag atacagcaag tctaactctc 1200
tgttccatta aacccttata ataaaatcct tctgtaataa taaagtttca aaagaaaatg 1260
tttatttgtt ctcattaaat gtattttagc aaactcagct cttccctatt gggaagagtt 1320
atgcaaattc tcctataagc aaaacaaagc atgtctttga gtaacaatga cctggaaata 1380
cccaaaattc caagttctcg atttcacatg ccttcaagac tgaacaccga ctaaggtttt 1440
catactatta gccaatgctg tagacagaag cattttgata ggaatagagc aaataagata 1500
atggccctga ggaatggcat gtcattatta aagatcatat ggggaaaatg aaaccctccc 1560
caaaatacaa gaagttctgg gaggagacat tgtcttcaga ctacaatgtc cagtttctcc 1620
cctagactca ggcttccttt ggagattaag gcccctcaga gatcaacaga ccaacatttt 1680
tctcttcctc aagcaacact cctagggcct ggcttctgtc tgatcaaggc accacacaac 1740
ccagaaagga gctgatgggg cagaatgaac tttaagtatg agaaaagttc agcccaagta 1800
aaataaaaac tcaatcacat tcaattccag agtagtttca agtttcacat cgtaaccatt 1860
ttcgcccgga attc                                                   1874

<210> 14
<211> 155
<212> PRT
<213> Homo sapiens

<400> 14
Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser
 1               5                  10                  15      
Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly
            20                  25                  30          
Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn
        35                  40                  45              
Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser
    50                  55                  60                  
Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu
65                  70                  75                  80  
Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His
                85                  90                  95      
Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser
            100                 105                 110         
Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His
        115                 120                 125             
Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys
    130                 135                 140                 
Thr Cys Val Thr Pro Ile Val His His Val Ala
145                 150                 155 


<210> 15
<211> 923
<212> DNA
<213> Homo sapiens

<400> 15
ggcttcagtt actagctagg ctactgagtt tagttctcag tttggcacct tgataccttt 60
aggtgtgagt gttcccattt ccaggtgagg aactgaggtg caaagagaag ccctgatccc 120
ataaaaggac aggaatgctg agttccgcca gaccatgcat ctcttgctag taggtgaggc 180
gagtctctaa ctgattgcag cgtcttctat tttccaggtc aagtacttgc tgctgtcgat 240
attggggctt gcctttctga gtgaggcggc agctcggaaa atccccaaag taggacatac 300
ttttttccaa aagcctgaga gttgcccgcc tgtgccagga ggtagtatga agcttgacat 360
tggcatcatc aatgaaaacc agcgcgtttc catgtcacgt aacatcgaga gccgctccac 420
ctccccctgg aattacactg tcacttggga ccccaaccgg tacccctcgg aagttgtaca 480
ggcccagtgt aggaacttgg gctgcatcaa tgctcaagga aaggaagaca tctccatgaa 540
ttccgttccc atccagcaag agaccctggt cgtccggagg aagcaccaag gctgctctgt 600
ttctttccag ttggagaagg tgctggtgac tgttggctgc acctgcgtca cccctgtcat 660
ccaccatgtg cagtaagagg tgcatatcca ctcagctgaa gaagctgtag aaatgccact 720
ccttacccag tgctctgcaa caagtcctgt ctgaccccca attccctcca cttcacagga 780
ctcttaataa gacctgcacg gatggaaaca taaaatattc acaatgtatg tgtgtatgta 840
ctacacttta tatttgatat ctaaaatgtt aggagaaaaa ttaatatatt cagtgctaat 900
ataataaagt attaataatg tta                                         923

<210> 16
<211> 153
<212> PRT
<213> Homo sapiens

<400> 16
Met Val Lys Tyr Leu Leu Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser
 1               5                  10                  15      
Glu Ala Ala Ala Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln
            20                  25                  30          
Lys Pro Glu Ser Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp
        35                  40                  45              
Ile Gly Ile Ile Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile
    50                  55                  60                  
Glu Ser Arg Ser Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro
65                  70                  75                  80  
Asn Arg Tyr Pro Ser Glu Val Val Gln Ala Gln Cys Arg Asn Leu Gly
                85                  90                  95      
Cys Ile Asn Ala Gln Gly Lys Glu Asp Ile Ser Met Asn Ser Val Pro
            100                 105                 110         
Ile Gln Gln Glu Thr Leu Val Val Arg Arg Lys His Gln Gly Cys Ser
        115                 120                 125             
Val Ser Phe Gln Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys
    130                 135                 140                 
Val Thr Pro Val Ile His His Val Gln
145                 150             


<210> 17
<211> 1172
<212> DNA
<213> Mus musculus

<400> 17
gatccacctc acacgaggca caagtgcacc cagcaccagc tgatcaggac gcgcaaacat 60
gagtccaggg agagcttcat ctgtgtctct gatgctgttg ctgctgctga gcctggcggc 120
tacagtgaag gcagcagcga tcatccctca aagctcagcg tgtccaaaca ctgaggccaa 180
ggacttcctc cagaatgtga aggtcaacct caaagtcttt aactcccttg gcgcaaaagt 240
gagctccaga aggccctcag actacctcaa ccgttccacg tcaccctgga ctctccaccg 300
caatgaagac cctgatagat atccctctgt gatctgggaa gctcagtgcc gccaccagcg 360
ctgtgtcaat gcggagggaa agctggacca ccacatgaat tctgttctca tccagcaaga 420
gatcctggtc ctgaagaggg agcctgagag ctgccccttc actttcaggg tcgagaagat 480
gctggtgggt gtgggctgca cctgcgtggc ctcgattgtc cgccaggcag cctaaacaga 540
gacccgcggc tgacccctaa gaaaccccca cgtttctcag caaacttact tgcattttta 600
aaacagttcg tgctattgat tttcagcaag gaatgtggat tcagaggcag attcagaatt 660
gtctgccctc cacaatgaaa agaaggtgta aaggggtccc aaactgcttc gtgtttgttt 720
ttctgtggac tttaaattat ttgtgtattt acaatatccc aagatagctt tgaagcgtaa 780
cttattttaa tgaagtatct acattattat tatgtttctt tctgaagaag acaaaattca 840
agactcagaa attttattat ttaaaaggta aagcctatat ttatatgagc tatttatgaa 900
tctatttatt tttcttcagt atttgaagta ttaagaacat gattttcaga tctacctagg 960
gaagtcctaa gtaagattaa atattaatgg aaatttcagc tttactattt gtttatttaa 1020
ggttctctcc tctgaatggg gtgaaaacca aacttagttt tatgtttaat aactttttaa 1080
attattgaag attcaaaaaa ttggataatt tagctcccta ctctgtttta aaaaaaaatt 1140
gtaacaatat cactgtaata ataaagtttt gg                               1172

<210> 18
<211> 158
<212> PRT
<213> Mus musculus

<400> 18
Met Ser Pro Gly Arg Ala Ser Ser Val Ser Leu Met Leu Leu Leu Leu
 1               5                  10                  15      
Leu Ser Leu Ala Ala Thr Val Lys Ala Ala Ala Ile Ile Pro Gln Ser
            20                  25                  30          
Ser Ala Cys Pro Asn Thr Glu Ala Lys Asp Phe Leu Gln Asn Val Lys
        35                  40                  45              
Val Asn Leu Lys Val Phe Asn Ser Leu Gly Ala Lys Val Ser Ser Arg
    50                  55                  60                  
Arg Pro Ser Asp Tyr Leu Asn Arg Ser Thr Ser Pro Trp Thr Leu His
65                  70                  75                  80  
Arg Asn Glu Asp Pro Asp Arg Tyr Pro Ser Val Ile Trp Glu Ala Gln
                85                  90                  95      
Cys Arg His Gln Arg Cys Val Asn Ala Glu Gly Lys Leu Asp His His
            100                 105                 110         
Met Asn Ser Val Leu Ile Gln Gln Glu Ile Leu Val Leu Lys Arg Glu
        115                 120                 125             
Pro Glu Ser Cys Pro Phe Thr Phe Arg Val Glu Lys Met Leu Val Gly
    130                 135                 140                 
Val Gly Cys Thr Cys Val Ala Ser Ile Val Arg Gln Ala Ala
145                 150                 155             


<210> 19
<211> 462
<212> DNA
<213> Mus musculus

<400> 19
atggtcaagt ctttgctact gttgatgttg ggacttgcca ttctgaggga ggtagcagct 60
cggaagaacc ccaaagcagg ggttcctgcc ttgcagaagg ctgggaactg tcctcccctg 120
gaggataaca ctgtgagagt tgacattcga atcttcaacc aaaaccaggg catttctgtc 180
ccacgtgaat tccagaaccg ctccagttcc ccatgggatt acaacatcac tcgagacccc 240
caccggttcc cctcagagat cgctgaggcc cagtgcagac actcaggctg catcaatgcc 300
cagggtcagg aagacagcac catgaactcc gtcgccattc agcaagaaat cctggtcctt 360
cggagggagc cccagggctg ttctaattcc ttcaggttgg agaagatgct cctaaaagtt 420
ggctgcacct gtgtcaagcc cattgtccac caagcggcct ga                    462

<210> 20
<211> 153
<212> PRT
<213> Mus musculus

<400> 20
Met Val Lys Ser Leu Leu Leu Leu Met Leu Gly Leu Ala Ile Leu Arg
 1               5                  10                  15      
Glu Val Ala Ala Arg Lys Asn Pro Lys Ala Gly Val Pro Ala Leu Gln
            20                  25                  30          
Lys Ala Gly Asn Cys Pro Pro Leu Glu Asp Asn Thr Val Arg Val Asp
        35                  40                  45              
Ile Arg Ile Phe Asn Gln Asn Gln Gly Ile Ser Val Pro Arg Glu Phe
    50                  55                  60                  
Gln Asn Arg Ser Ser Ser Pro Trp Asp Tyr Asn Ile Thr Arg Asp Pro
65                  70                  75                  80  
His Arg Phe Pro Ser Glu Ile Ala Glu Ala Gln Cys Arg His Ser Gly
                85                  90                  95      
Cys Ile Asn Ala Gln Gly Gln Glu Asp Ser Thr Met Asn Ser Val Ala
            100                 105                 110         
Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Gln Gly Cys Ser
        115                 120                 125             
Asn Ser Phe Arg Leu Glu Lys Met Leu Leu Lys Val Gly Cys Thr Cys
    130                 135                 140                 
Val Lys Pro Ile Val His Gln Ala Ala
145                 150             


<210> 21
<211> 320
<212> PRT
<213> Homo sapien

<400> 21
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu
 1               5                  10                  15      
Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser
            20                  25                  30          
Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu
        35                  40                  45              
Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His
    50                  55                  60                  
Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu
65                  70                  75                  80  
His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile
                85                  90                  95      
Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala
            100                 105                 110         
Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg
        115                 120                 125             
Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe
    130                 135                 140                 
Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr
145                 150                 155                 160 
Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln
                165                 170                 175     
Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val
            180                 185                 190         
Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr
        195                 200                 205             
Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp
    210                 215                 220                 
Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met
225                 230                 235                 240 
Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg
                245                 250                 255     
Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn
            260                 265                 270         
Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser
        275                 280                 285             
Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro
    290                 295                 300                 
Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp
305                 310                 315                 320 


<210> 22
<211> 221
<212> PRT
<213> Homo sapien

<400> 22
Lys Pro Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu
 1               5                  10                  15      
Asn His Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu
            20                  25                  30          
Glu Pro Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro
        35                  40                  45              
Arg Ala His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr
    50                  55                  60                  
Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala
65                  70                  75                  80  
Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val
                85                  90                  95      
Pro Pro Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe
            100                 105                 110         
Pro Leu Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser
        115                 120                 125             
Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro
    130                 135                 140                 
Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn
145                 150                 155                 160 
Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser
                165                 170                 175     
Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp
            180                 185                 190         
Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala
        195                 200                 205             
Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Lys Arg
    210                 215                 220     


<210> 23
<211> 2180
<212> DNA
<213> Homo sapien

<400> 23
aactacccag cacagccccc tccgccccct ctggaggctg aagagggatt ccagcccctg 60
ccacccacag acacgggctg actggggtgt ctgcccccct tggggggggg cagcacaggg 120
cctcaggcct gggtgccacc tggcacctag aagatgcctg tgccctggtt cttgctgtcc 180
ttggcactgg gccgaagccc agtggtcctt tctctggaga ggcttgtggg gcctcaggac 240
gctacccact gctctccggg cctctcctgc cgcctctggg acagtgacat actctgcctg 300
cctggggaca tcgtgcctgc tccgggcccc gtgctggcgc ctacgcacct gcagacagag 360
ctggtgctga ggtgccagaa ggagaccgac tgtgacctct gtctgcgtgt ggctgtccac 420
ttggccgtgc atgcctctct ccaggcccaa gtcgtgctct ccttccaggc ctaccctact 480
gcccgctgcg tcctgctgga ggtgcaagtg cctgctgccc ttgtgcagtt tggtcagtct 540
gtgggctctg tggtatatga ctgcttcgag gctgccctag ggagtgaggt acgaatctgg 600
tcctatactc agcccaggta cgagaaggaa ctcaaccaca cacagcagct gcctgccctg 660
ccctggctca acgtgtcagc agatggtgac aacgtgcatc tggttctgaa tgtctctgag 720
gagcagcact tcggcctctc cctgtactgg aatcaggtcc agggcccccc aaaaccccgg 780
tggcacaaaa acctgactgg accgcagatc attaccttga accacacaga cctggttccc 840
tgcctctgta ttcaggtgtg gcctctggaa cctgactccg ttaggacgaa catctgcccc 900
ttcagggagg acccccgcgc acaccagaac ctctggcaag ccgcccgact gcgactgctg 960
accctgcaga gctggctgct ggacgcaccg tgctcgctgc ccgcagaagc ggcactgtgc 1020
tggcgggctc cgggtgggga cccctgccag ccactggtcc caccgctttc ctgggagaac 1080
gtcactgtgg acaaggttct cgagttccca ttgctgaaag gccaccctaa cctctgtgtt 1140
caggtgaaca gctcggagaa gctgcagctg caggagtgct tgtgggctga ctccctgggg 1200
cctctcaaag acgatgtgct actgttggag acacgaggcc cccaggacaa cagatccctc 1260
tgtgccttgg aacccagtgg ctgtacttca ctacccagca aagcctccac gagggcagct 1320
cgccttggag agtacttact acaagacctg cagtcaggcc agtgtctgca gctatgggac 1380
gatgacttgg gagcgctatg ggcctgcccc atggacaaat acatccacaa gcgctgggcc 1440
ctcgtgtggc tggcctgcct actctttgcc gctgcgcttt ccctcatcct ccttctcaaa 1500
aaggatcacg cgaaagcggc cgccaggggc cgcgcggctc tgctcctcta ctcagccgat 1560
gactcgggtt tcgagcgcct ggtgggcgcc ctggcgtcgg ccctgtgcca gctgccgctg 1620
cgcgtggccg tagacctgtg gagccgtcgt gaactgagcg cgcaggggcc cgtggcttgg 1680
tttcacgcgc agcggcgcca gaccctgcag gagggcggcg tggtggtctt gctcttctct 1740
cccggtgcgg tggcgctgtg cagcgagtgg ctacaggatg gggtgtccgg gcccggggcg 1800
cacggcccgc acgacgcctt ccgcgcctcg ctcagctgcg tgctgcccga cttcttgcag 1860
ggccgggcgc ccggcagcta cgtgggggcc tgcttcgaca ggctgctcca cccggacgcc 1920
gtacccgccc ttttccgcac cgtgcccgtc ttcacactgc cctcccaact gccagacttc 1980
ctgggggccc tgcagcagcc tcgcgccccg cgttccgggc ggctccaaga gagagcggag 2040
caagtgtccc gggcccttca gccagccctg gatagctact tccatccccc ggggactccc 2100
gcgccgggac gcggggtggg accaggggcg ggacctgggg cgggggacgg gacttaaata 2160
aaggcagacg ctgtttttct                                             2180

<210> 24
<211> 667
<212> PRT
<213> Homo sapien

<400> 24
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Ala Ser Leu
                85                  90                  95      
Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala Arg Cys
            100                 105                 110         
Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe Gly Gln
        115                 120                 125             
Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu Gly Ser
    130                 135                 140                 
Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys Glu Leu
145                 150                 155                 160 
Asn His Thr Gln Gln Leu Pro Ala Leu Pro Trp Leu Asn Val Ser Ala
                165                 170                 175     
Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His
            180                 185                 190         
Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro
        195                 200                 205             
Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His
    210                 215                 220                 
Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro
225                 230                 235                 240 
Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala
                245                 250                 255     
His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln
            260                 265                 270         
Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu
        275                 280                 285             
Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro
    290                 295                 300                 
Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu
305                 310                 315                 320 
Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys
                325                 330                 335     
Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys
            340                 345                 350         
Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser
        355                 360                 365             
Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala
    370                 375                 380                 
Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln
385                 390                 395                 400 
Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp
                405                 410                 415     
Ala Cys Pro Met Asp Lys Tyr Ile His Lys Arg Trp Ala Leu Val Trp
            420                 425                 430         
Leu Ala Cys Leu Leu Phe Ala Ala Ala Leu Ser Leu Ile Leu Leu Leu
        435                 440                 445             
Lys Lys Asp His Ala Lys Ala Ala Ala Arg Gly Arg Ala Ala Leu Leu
    450                 455                 460                 
Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu Arg Leu Val Gly Ala Leu
465                 470                 475                 480 
Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg Val Ala Val Asp Leu Trp
                485                 490                 495     
Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro Val Ala Trp Phe His Ala
            500                 505                 510         
Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly Val Val Val Leu Leu Phe
        515                 520                 525             
Ser Pro Gly Ala Val Ala Leu Cys Ser Glu Trp Leu Gln Asp Gly Val
    530                 535                 540                 
Ser Gly Pro Gly Ala His Gly Pro His Asp Ala Phe Arg Ala Ser Leu
545                 550                 555                 560 
Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg Ala Pro Gly Ser Tyr
                565                 570                 575     
Val Gly Ala Cys Phe Asp Arg Leu Leu His Pro Asp Ala Val Pro Ala
            580                 585                 590         
Leu Phe Arg Thr Val Pro Val Phe Thr Leu Pro Ser Gln Leu Pro Asp
        595                 600                 605             
Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala Pro Arg Ser Gly Arg Leu
    610                 615                 620                 
Gln Glu Arg Ala Glu Gln Val Ser Arg Ala Leu Gln Pro Ala Leu Asp
625                 630                 635                 640 
Ser Tyr Phe His Pro Pro Gly Thr Pro Ala Pro Gly Arg Gly Val Gly
                645                 650                 655     
Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly Thr
            660                 665         


<210> 25
<211> 2269
<212> DNA
<213> Mus musculus

<400> 25
aaatcgaaag cactccagct gaaactgggc ctggagtcca ggctcactgg agtggggaag 60
catggctgga gaggaattct agcccttgct ctctcccagg gacacggggc tgattgtcag 120
caggggcgag gggtctgccc ccccttgggg gggcaggacg gggcctcagg cctgggtgct 180
gtccggcacc tggaagatgc ctgtgtcctg gttcctgctg tccttggcac tgggccgaaa 240
ccctgtggtc gtctctctgg agagactgat ggagcctcag gacactgcac gctgctctct 300
aggcctctcc tgccacctct gggatggtga cgtgctctgc ctgcctggaa gcctccagtc 360
tgccccaggc cctgtgctag tgcctacccg cctgcagacg gagctggtgc tgaggtgtcc 420
acagaagaca gattgcgccc tctgtgtccg tgtggtggtc cacttggccg tgcatgggca 480
ctgggcagag cctgaagaag ctggaaagtc tgattcagaa ctccaggagt ctaggaacgc 540
ctctctccag gcccaggtgg tgctctcctt ccaggcctac cccatcgccc gctgtgccct 600
gctggaggtc caggtgcccg ctgacctggt gcagcctggt cagtccgtgg gttctgcggt 660
atttgactgt ttcgaggcta gtcttggggc tgaggtacag atctggtcct acacgaagcc 720
caggtaccag aaagagctca acctcacaca gcagctgcct gtcctgccct ggctcaatgt 780
gtctacagat ggtgacaatg tccttctgac actggatgtc tctgaggagc aggactttag 840
cttcttactg tacctgcgtc cagtcccgga tgctctcaaa tccttgtggt acaaaaacct 900
gactggacct cagaacatta ctttaaacca cacagacctg gttccctgcc tctgcattca 960
ggtgtggtcg ctagagccag actctgagag ggtcgaattc tgccccttcc gggaagatcc 1020
cggtgcacac aggaacctct ggcacatagc caggctgcgg gtactgtccc caggggtatg 1080
gcagctagat gcgccttgct gtctgccggg caaggtaaca ctgtgctggc aggcaccaga 1140
ccagagtccc tgccagccac ttgtgccacc agtgccccag aagaacgcca ctgtgaatga 1200
gccacaagat ttccagttgg tggcaggcca ccccaacctc tgtgtccagg tgagcacctg 1260
ggagaaggtt cagctgcaag cgtgcttgtg ggctgactcc ttggggccct tcaaggatga 1320
tatgctgtta gtggagatga aaaccggcct caacaacaca tcagtctgtg ccttggaacc 1380
cagtggctgt acaccactgc ccagcatggc ctccacgaga gctgctcgcc tgggagagga 1440
gttgctgcaa gacttccgat cacaccagtg tatgcagctg tggaacgatg acaacatggg 1500
atcgctatgg gcctgcccca tggacaagta catccacagg cgctgggtcc tagtatggct 1560
ggcctgccta ctcttggctg cggcgctttt cttcttcctc cttctaaaaa aggaccgcag 1620
gaaagcggcc cgtggctccc gcacggcctt gctcctccac tccgccgacg gagcgggcta 1680
cgagcgtctg gtgggagcac tggcgtccgc gttgagccag atgccactgc gcgtggccgt 1740
ggacctgtgg agccgccgcg agctgagcgc gcacggagcc ctagcctggt tccaccacca 1800
gcgacgccgt atcctgcagg agggtggcgt ggtaatcctt ctcttctcgc ccgcggccgt 1860
ggcgcagtgt cagcagtggc tgcagctcca gacagtggag cccgggccgc atgacgccct 1920
cgccgcctgg ctcagctgcg tgctacccga tttcctgcaa ggccgggcga ccggccgcta 1980
cgtcggggtc tacttcgacg ggctgctgca cccagactct gtgccctccc cgttccgcgt 2040
cgccccgctc ttctccctgc cctcgcagct gccggctttc ctggatgcac tgcagggagg 2100
ctgctccact tccgcggggc gacccgcgga ccgggtggaa cgagtgaccc aggcgctgcg 2160
gtccgccctg gacagctgta cttctagctc ggaagcccca ggctgctgcg aggaatggga 2220
cctgggaccc tgcactacac tagaataaaa gccgatacag tattcctaa             2269

<210> 26
<211> 683
<212> PRT
<213> Mus musculus

<400> 26
Met Pro Val Ser Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Asn Pro
 1               5                  10                  15      
Val Val Val Ser Leu Glu Arg Leu Met Glu Pro Gln Asp Thr Ala Arg
            20                  25                  30          
Cys Ser Leu Gly Leu Ser Cys His Leu Trp Asp Gly Asp Val Leu Cys
        35                  40                  45              
Leu Pro Gly Ser Leu Gln Ser Ala Pro Gly Pro Val Leu Val Pro Thr
    50                  55                  60                  
Arg Leu Gln Thr Glu Leu Val Leu Arg Cys Pro Gln Lys Thr Asp Cys
65                  70                  75                  80  
Ala Leu Cys Val Arg Val Val Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Ala Glu Pro Glu Glu Ala Gly Lys Ser Asp Ser Glu Leu Gln Glu Ser
            100                 105                 110         
Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr
        115                 120                 125             
Pro Ile Ala Arg Cys Ala Leu Leu Glu Val Gln Val Pro Ala Asp Leu
    130                 135                 140                 
Val Gln Pro Gly Gln Ser Val Gly Ser Ala Val Phe Asp Cys Phe Glu
145                 150                 155                 160 
Ala Ser Leu Gly Ala Glu Val Gln Ile Trp Ser Tyr Thr Lys Pro Arg
                165                 170                 175     
Tyr Gln Lys Glu Leu Asn Leu Thr Gln Gln Leu Pro Val Leu Pro Trp
            180                 185                 190         
Leu Asn Val Ser Thr Asp Gly Asp Asn Val Leu Leu Thr Leu Asp Val
        195                 200                 205             
Ser Glu Glu Gln Asp Phe Ser Phe Leu Leu Tyr Leu Arg Pro Val Pro
    210                 215                 220                 
Asp Ala Leu Lys Ser Leu Trp Tyr Lys Asn Leu Thr Gly Pro Gln Asn
225                 230                 235                 240 
Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val
                245                 250                 255     
Trp Ser Leu Glu Pro Asp Ser Glu Arg Val Glu Phe Cys Pro Phe Arg
            260                 265                 270         
Glu Asp Pro Gly Ala His Arg Asn Leu Trp His Ile Ala Arg Leu Arg
        275                 280                 285             
Val Leu Ser Pro Gly Val Trp Gln Leu Asp Ala Pro Cys Cys Leu Pro
    290                 295                 300                 
Gly Lys Val Thr Leu Cys Trp Gln Ala Pro Asp Gln Ser Pro Cys Gln
305                 310                 315                 320 
Pro Leu Val Pro Pro Val Pro Gln Lys Asn Ala Thr Val Asn Glu Pro
                325                 330                 335     
Gln Asp Phe Gln Leu Val Ala Gly His Pro Asn Leu Cys Val Gln Val
            340                 345                 350         
Ser Thr Trp Glu Lys Val Gln Leu Gln Ala Cys Leu Trp Ala Asp Ser
        355                 360                 365             
Leu Gly Pro Phe Lys Asp Asp Met Leu Leu Val Glu Met Lys Thr Gly
    370                 375                 380                 
Leu Asn Asn Thr Ser Val Cys Ala Leu Glu Pro Ser Gly Cys Thr Pro
385                 390                 395                 400 
Leu Pro Ser Met Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Glu Leu
                405                 410                 415     
Leu Gln Asp Phe Arg Ser His Gln Cys Met Gln Leu Trp Asn Asp Asp
            420                 425                 430         
Asn Met Gly Ser Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Arg
        435                 440                 445             
Arg Trp Val Leu Val Trp Leu Ala Cys Leu Leu Leu Ala Ala Ala Leu
    450                 455                 460                 
Phe Phe Phe Leu Leu Leu Lys Lys Asp Arg Arg Lys Ala Ala Arg Gly
465                 470                 475                 480 
Ser Arg Thr Ala Leu Leu Leu His Ser Ala Asp Gly Ala Gly Tyr Glu
                485                 490                 495     
Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Ser Gln Met Pro Leu Arg
            500                 505                 510         
Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala His Gly Ala
        515                 520                 525             
Leu Ala Trp Phe His His Gln Arg Arg Arg Ile Leu Gln Glu Gly Gly
    530                 535                 540                 
Val Val Ile Leu Leu Phe Ser Pro Ala Ala Val Ala Gln Cys Gln Gln
545                 550                 555                 560 
Trp Leu Gln Leu Gln Thr Val Glu Pro Gly Pro His Asp Ala Leu Ala
                565                 570                 575     
Ala Trp Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg Ala Thr
            580                 585                 590         
Gly Arg Tyr Val Gly Val Tyr Phe Asp Gly Leu Leu His Pro Asp Ser
        595                 600                 605             
Val Pro Ser Pro Phe Arg Val Ala Pro Leu Phe Ser Leu Pro Ser Gln
    610                 615                 620                 
Leu Pro Ala Phe Leu Asp Ala Leu Gln Gly Gly Cys Ser Thr Ser Ala
625                 630                 635                 640 
Gly Arg Pro Ala Asp Arg Val Glu Arg Val Thr Gln Ala Leu Arg Ser
                645                 650                 655     
Ala Leu Asp Ser Cys Thr Ser Ser Ser Glu Ala Pro Gly Cys Cys Glu
            660                 665                 670         
Glu Trp Asp Leu Gly Pro Cys Thr Thr Leu Glu
        675                 680             


<210> 27
<211> 449
<212> PRT
<213> Mus musculus

<400> 27
Met Pro Val Ser Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Asn Pro
 1               5                  10                  15      
Val Val Val Ser Leu Glu Arg Leu Met Glu Pro Gln Asp Thr Ala Arg
            20                  25                  30          
Cys Ser Leu Gly Leu Ser Cys His Leu Trp Asp Gly Asp Val Leu Cys
        35                  40                  45              
Leu Pro Gly Ser Leu Gln Ser Ala Pro Gly Pro Val Leu Val Pro Thr
    50                  55                  60                  
Arg Leu Gln Thr Glu Leu Val Leu Arg Cys Pro Gln Lys Thr Asp Cys
65                  70                  75                  80  
Ala Leu Cys Val Arg Val Val Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Ala Glu Pro Glu Glu Ala Gly Lys Ser Asp Ser Glu Leu Gln Glu Ser
            100                 105                 110         
Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr
        115                 120                 125             
Pro Ile Ala Arg Cys Ala Leu Leu Glu Val Gln Val Pro Ala Asp Leu
    130                 135                 140                 
Val Gln Pro Gly Gln Ser Val Gly Ser Ala Val Phe Asp Cys Phe Glu
145                 150                 155                 160 
Ala Ser Leu Gly Ala Glu Val Gln Ile Trp Ser Tyr Thr Lys Pro Arg
                165                 170                 175     
Tyr Gln Lys Glu Leu Asn Leu Thr Gln Gln Leu Pro Val Leu Pro Trp
            180                 185                 190         
Leu Asn Val Ser Thr Asp Gly Asp Asn Val Leu Leu Thr Leu Asp Val
        195                 200                 205             
Ser Glu Glu Gln Asp Phe Ser Phe Leu Leu Tyr Leu Arg Pro Val Pro
    210                 215                 220                 
Asp Ala Leu Lys Ser Leu Trp Tyr Lys Asn Leu Thr Gly Pro Gln Asn
225                 230                 235                 240 
Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val
                245                 250                 255     
Trp Ser Leu Glu Pro Asp Ser Glu Arg Val Glu Phe Cys Pro Phe Arg
            260                 265                 270         
Glu Asp Pro Gly Ala His Arg Asn Leu Trp His Ile Ala Arg Leu Arg
        275                 280                 285             
Val Leu Ser Pro Gly Val Trp Gln Leu Asp Ala Pro Cys Cys Leu Pro
    290                 295                 300                 
Gly Lys Val Thr Leu Cys Trp Gln Ala Pro Asp Gln Ser Pro Cys Gln
305                 310                 315                 320 
Pro Leu Val Pro Pro Val Pro Gln Lys Asn Ala Thr Val Asn Glu Pro
                325                 330                 335     
Gln Asp Phe Gln Leu Val Ala Gly His Pro Asn Leu Cys Val Gln Val
            340                 345                 350         
Ser Thr Trp Glu Lys Val Gln Leu Gln Ala Cys Leu Trp Ala Asp Ser
        355                 360                 365             
Leu Gly Pro Phe Lys Asp Asp Met Leu Leu Val Glu Met Lys Thr Gly
    370                 375                 380                 
Leu Asn Asn Thr Ser Val Cys Ala Leu Glu Pro Ser Gly Cys Thr Pro
385                 390                 395                 400 
Leu Pro Ser Met Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Glu Leu
                405                 410                 415     
Leu Gln Asp Phe Arg Ser His Gln Cys Met Gln Leu Trp Asn Asp Asp
            420                 425                 430         
Asn Met Gly Ser Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Arg
        435                 440                 445             
Arg
    


<210> 28
<211> 222
<212> PRT
<213> Mus musculus

<400> 28
Lys Ser Leu Trp Tyr Lys Asn Leu Thr Gly Pro Gln Asn Ile Thr Leu
 1               5                  10                  15      
Asn His Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Ser Leu
            20                  25                  30          
Glu Pro Asp Ser Glu Arg Val Glu Phe Cys Pro Phe Arg Glu Asp Pro
        35                  40                  45              
Gly Ala His Arg Asn Leu Trp His Ile Ala Arg Leu Arg Val Leu Ser
    50                  55                  60                  
Pro Gly Val Trp Gln Leu Asp Ala Pro Cys Cys Leu Pro Gly Lys Val
65                  70                  75                  80  
Thr Leu Cys Trp Gln Ala Pro Asp Gln Ser Pro Cys Gln Pro Leu Val
                85                  90                  95      
Pro Pro Val Pro Gln Lys Asn Ala Thr Val Asn Glu Pro Gln Asp Phe
            100                 105                 110         
Gln Leu Val Ala Gly His Pro Asn Leu Cys Val Gln Val Ser Thr Trp
        115                 120                 125             
Glu Lys Val Gln Leu Gln Ala Cys Leu Trp Ala Asp Ser Leu Gly Pro
    130                 135                 140                 
Phe Lys Asp Asp Met Leu Leu Val Glu Met Lys Thr Gly Leu Asn Asn
145                 150                 155                 160 
Thr Ser Val Cys Ala Leu Glu Pro Ser Gly Cys Thr Pro Leu Pro Ser
                165                 170                 175     
Met Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Glu Leu Leu Gln Asp
            180                 185                 190         
Phe Arg Ser His Gln Cys Met Gln Leu Trp Asn Asp Asp Asn Met Gly
        195                 200                 205             
Ser Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Arg Arg
    210                 215                 220         


<210> 29
<211> 2287
<212> DNA
<213> Mus musculus

<400> 29
aaatcgaaag cactccagct gaaactgggc ctggagtcca ggctcactgg agtggggaag 60
catggctgga gaggaattct agcccttgct ctctcccagg gacacggggc tgattgtcag 120
caggggcgag gggtctgccc ccccttgggg gggcaggacg gggcctcagg cctgggtgct 180
gtccggcacc tggaagatgc ctgtgtcctg gttcctgctg tccttggcac tgggccgaaa 240
ccctgtggtc gtctctctgg agagactgat ggagcctcag gacactgcac gctgctctct 300
aggcctctcc tgccacctct gggatggtga cgtgctctgc ctgcctggaa gcctccagtc 360
tgccccaggc cctgtgctag tgcctacccg cctgcagacg gagctggtgc tgaggtgtcc 420
acagaagaca gattgcgccc tctgtgtccg tgtggtggtc cacttggccg tgcatgggca 480
ctgggcagag cctgaagaag ctggaaagtc tgattcagaa ctccaggagt ctaggaacgc 540
ctctctccag gcccaggtgg tgctctcctt ccaggcctac cccatcgccc gctgtgccct 600
gctggaggtc caggtgcccg ctgacctggt gcagcctggt cagtccgtgg gttctgcggt 660
atttgactgt ttcgaggcta gtcttggggc tgaggtacag atctggtcct acacgaagcc 720
caggtaccag aaagagctca acctcacaca gcagctgcct gactgcaggg gtcttgaagt 780
ccgggacagc atccagagct gctgggatgg tgacaatgtc cttctgacac tggatgtctc 840
tgaggagcag gactttagct tcttactgta cctgcgtcca gtcccggatg ctctcaaatc 900
cttgtggtac aaaaacctga ctggacctca gaacattact ttaaaccaca cagacctggt 960
tccctgcctc tgcattcagg tgtggtcgct agagccagac tctgagaggg tcgaattctg 1020
ccccttccgg gaagatcccg gtgcacacag gaacctctgg cacatagcca ggctgcgggt 1080
actgtcccca ggggtatggc agctagatgc gccttgctgt ctgccgggca aggtaacact 1140
gtgctggcag gcaccagacc agagtccctg ccagccactt gtgccaccag tgccccagaa 1200
gaacgccact gtgaatgagc cacaagattt ccagttggtg gcaggccacc ccaacctctg 1260
tgtccaggtg agcacctggg agaaggttca gctgcaagcg tgcttgtggg ctgactcctt 1320
ggggcccttc aaggatgata tgctgttagt ggagatgaaa accggcctca acaacacatc 1380
agtctgtgcc ttggaaccca gtggctgtac accactgccc agcatggcct ccacgagagc 1440
tgctcgcctg ggagaggagt tgctgcaaga cttccgatca caccagtgta tgcagctgtg 1500
gaacgatgac aacatgggat cgctatgggc ctgccccatg gacaagtaca tccacaggcg 1560
ctgggtccta gtatggctgg cctgcctact cttggctgcg gcgcttttct tcttcctcct 1620
tctaaaaaag gaccgcagga aagcggcccg tggctcccgc acggccttgc tcctccactc 1680
cgccgacgga gcgggctacg agcgtctggt gggagcactg gcgtccgcgt tgagccagat 1740
gccactgcgc gtggccgtgg acctgtggag ccgccgcgag ctgagcgcgc acggagccct 1800
agcctggttc caccaccagc gacgccgtat cctgcaggag ggtggcgtgg taatccttct 1860
cttctcgccc gcggccgtgg cgcagtgtca gcagtggctg cagctccaga cagtggagcc 1920
cgggccgcat gacgccctcg ccgcctggct cagctgcgtg ctacccgatt tcctgcaagg 1980
ccgggcgacc ggccgctacg tcggggtcta cttcgacggg ctgctgcacc cagactctgt 2040
gccctccccg ttccgcgtcg ccccgctctt ctccctgccc tcgcagctgc cggctttcct 2100
ggatgcactg cagggaggct gctccacttc cgcggggcga cccgcggacc gggtggaacg 2160
agtgacccag gcgctgcggt ccgccctgga cagctgtact tctagctcgg aagccccagg 2220
ctgctgcgag gaatgggacc tgggaccctg cactacacta gaataaaagc cgatacagta 2280
ttcctaa                                                           2287

<210> 30
<211> 689
<212> PRT
<213> Mus musculus

<400> 30
Met Pro Val Ser Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Asn Pro
 1               5                  10                  15      
Val Val Val Ser Leu Glu Arg Leu Met Glu Pro Gln Asp Thr Ala Arg
            20                  25                  30          
Cys Ser Leu Gly Leu Ser Cys His Leu Trp Asp Gly Asp Val Leu Cys
        35                  40                  45              
Leu Pro Gly Ser Leu Gln Ser Ala Pro Gly Pro Val Leu Val Pro Thr
    50                  55                  60                  
Arg Leu Gln Thr Glu Leu Val Leu Arg Cys Pro Gln Lys Thr Asp Cys
65                  70                  75                  80  
Ala Leu Cys Val Arg Val Val Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Ala Glu Pro Glu Glu Ala Gly Lys Ser Asp Ser Glu Leu Gln Glu Ser
            100                 105                 110         
Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr
        115                 120                 125             
Pro Ile Ala Arg Cys Ala Leu Leu Glu Val Gln Val Pro Ala Asp Leu
    130                 135                 140                 
Val Gln Pro Gly Gln Ser Val Gly Ser Ala Val Phe Asp Cys Phe Glu
145                 150                 155                 160 
Ala Ser Leu Gly Ala Glu Val Gln Ile Trp Ser Tyr Thr Lys Pro Arg
                165                 170                 175     
Tyr Gln Lys Glu Leu Asn Leu Thr Gln Gln Leu Pro Asp Cys Arg Gly
            180                 185                 190         
Leu Glu Val Arg Asp Ser Ile Gln Ser Cys Trp Asp Gly Asp Asn Val
        195                 200                 205             
Leu Leu Thr Leu Asp Val Ser Glu Glu Gln Asp Phe Ser Phe Leu Leu
    210                 215                 220                 
Tyr Leu Arg Pro Val Pro Asp Ala Leu Lys Ser Leu Trp Tyr Lys Asn
225                 230                 235                 240 
Leu Thr Gly Pro Gln Asn Ile Thr Leu Asn His Thr Asp Leu Val Pro
                245                 250                 255     
Cys Leu Cys Ile Gln Val Trp Ser Leu Glu Pro Asp Ser Glu Arg Val
            260                 265                 270         
Glu Phe Cys Pro Phe Arg Glu Asp Pro Gly Ala His Arg Asn Leu Trp
        275                 280                 285             
His Ile Ala Arg Leu Arg Val Leu Ser Pro Gly Val Trp Gln Leu Asp
    290                 295                 300                 
Ala Pro Cys Cys Leu Pro Gly Lys Val Thr Leu Cys Trp Gln Ala Pro
305                 310                 315                 320 
Asp Gln Ser Pro Cys Gln Pro Leu Val Pro Pro Val Pro Gln Lys Asn
                325                 330                 335     
Ala Thr Val Asn Glu Pro Gln Asp Phe Gln Leu Val Ala Gly His Pro
            340                 345                 350         
Asn Leu Cys Val Gln Val Ser Thr Trp Glu Lys Val Gln Leu Gln Ala
        355                 360                 365             
Cys Leu Trp Ala Asp Ser Leu Gly Pro Phe Lys Asp Asp Met Leu Leu
    370                 375                 380                 
Val Glu Met Lys Thr Gly Leu Asn Asn Thr Ser Val Cys Ala Leu Glu
385                 390                 395                 400 
Pro Ser Gly Cys Thr Pro Leu Pro Ser Met Ala Ser Thr Arg Ala Ala
                405                 410                 415     
Arg Leu Gly Glu Glu Leu Leu Gln Asp Phe Arg Ser His Gln Cys Met
            420                 425                 430         
Gln Leu Trp Asn Asp Asp Asn Met Gly Ser Leu Trp Ala Cys Pro Met
        435                 440                 445             
Asp Lys Tyr Ile His Arg Arg Trp Val Leu Val Trp Leu Ala Cys Leu
    450                 455                 460                 
Leu Leu Ala Ala Ala Leu Phe Phe Phe Leu Leu Leu Lys Lys Asp Arg
465                 470                 475                 480 
Arg Lys Ala Ala Arg Gly Ser Arg Thr Ala Leu Leu Leu His Ser Ala
                485                 490                 495     
Asp Gly Ala Gly Tyr Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu
            500                 505                 510         
Ser Gln Met Pro Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu
        515                 520                 525             
Leu Ser Ala His Gly Ala Leu Ala Trp Phe His His Gln Arg Arg Arg
    530                 535                 540                 
Ile Leu Gln Glu Gly Gly Val Val Ile Leu Leu Phe Ser Pro Ala Ala
545                 550                 555                 560 
Val Ala Gln Cys Gln Gln Trp Leu Gln Leu Gln Thr Val Glu Pro Gly
                565                 570                 575     
Pro His Asp Ala Leu Ala Ala Trp Leu Ser Cys Val Leu Pro Asp Phe
            580                 585                 590         
Leu Gln Gly Arg Ala Thr Gly Arg Tyr Val Gly Val Tyr Phe Asp Gly
        595                 600                 605             
Leu Leu His Pro Asp Ser Val Pro Ser Pro Phe Arg Val Ala Pro Leu
    610                 615                 620                 
Phe Ser Leu Pro Ser Gln Leu Pro Ala Phe Leu Asp Ala Leu Gln Gly
625                 630                 635                 640 
Gly Cys Ser Thr Ser Ala Gly Arg Pro Ala Asp Arg Val Glu Arg Val
                645                 650                 655     
Thr Gln Ala Leu Arg Ser Ala Leu Asp Ser Cys Thr Ser Ser Ser Glu
            660                 665                 670         
Ala Pro Gly Cys Cys Glu Glu Trp Asp Leu Gly Pro Cys Thr Thr Leu
        675                 680                 685             
Glu
    


<210> 31
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 31
tcccgtcccc cgccccaggt c                                           21

<210> 32
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 32
ctctccatcc ttatctttca tcaac                                       25

<210> 33
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 33
ctctctgctg gctaaacaaa acac                                        24

<210> 34
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 34
ctcatattgc tcaactgtgt gaaaag                                      26

<210> 35
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 35
tagaagccac ctgaacacaa atctg                                       25

<210> 36
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 36
atcttgcgtt gtatgttgaa aatcaatt                                    28

<210> 37
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 37
ttctccacca ggtaaacaag tctac                                       25

<210> 38
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 38
ctctccaggc ccaagtcgtg ctct                                        24

<210> 39
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 39
ttgtcctggg ggcctcgtgt ctcc                                        24

<210> 40
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 40
acgaagccca ggtaccagaa agag                                        24

<210> 41
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 41
aaaagcgccg cagccaagag tagg                                        24

<210> 42
<211> 1293
<212> DNA
<213> Homo sapiens

<400> 42
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 60
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 120
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 180
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 240
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 300
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 360
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 420
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 480
tacgagaagg aactcaacca cacacagcag ctgcctgccc tgccctggct caacgtgtca 540
gcagatggtg acaacgtgca tctggttctg aatgtctctg aggagcagca cttcggcctc 600
tccctgtact ggaatcaggt ccagggcccc ccaaaacccc ggtggcacaa aaacctgact 660
ggaccgcaga tcattacctt gaaccacaca gacctggttc cctgcctctg tattcaggtg 720
tggcctctgg aacctgactc cgttaggacg aacatctgcc ccttcaggga ggacccccgc 780
gcacaccaga acctctggca agccgcccga ctgcgactgc tgaccctgca gagctggctg 840
ctggacgcac cgtgctcgct gcccgcagaa gcggcactgt gctggcgggc tccgggtggg 900
gacccctgcc agccactggt cccaccgctt tcctgggaga acgtcactgt ggacaaggtt 960
ctcgagttcc cattgctgaa aggccaccct aacctctgtg ttcaggtgaa cagctcggag 1020
aagctgcagc tgcaggagtg cttgtgggct gactccctgg ggcctctcaa agacgatgtg 1080
ctactgttgg agacacgagg cccccaggac aacagatccc tctgtgcctt ggaacccagt 1140
ggctgtactt cactacccag caaagcctcc acgagggcag ctcgccttgg agagtactta 1200
ctacaagacc tgcagtcagg ccagtgtctg cagctatggg acgatgactt gggagcgcta 1260
tgggcctgcc ccatggacaa atacatccac aag                              1293

<210> 43
<211> 431
<212> PRT
<213> Homo sapiens

<400> 43
Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His Cys Ser Pro Gly
 1               5                  10                  15      
Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys Leu Pro Gly Asp
            20                  25                  30          
Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr His Leu Gln Thr
        35                  40                  45              
Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys Asp Leu Cys Leu
    50                  55                  60                  
Arg Val Ala Val His Leu Ala Val His Gly His Trp Glu Glu Pro Glu
65                  70                  75                  80  
Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro
                85                  90                  95      
Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr
            100                 105                 110         
Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu
        115                 120                 125             
Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu
    130                 135                 140                 
Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg
145                 150                 155                 160 
Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro Ala Leu Pro Trp
                165                 170                 175     
Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val Leu Asn Val
            180                 185                 190         
Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln
        195                 200                 205             
Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile
    210                 215                 220                 
Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val
225                 230                 235                 240 
Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg
                245                 250                 255     
Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg
            260                 265                 270         
Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro
        275                 280                 285             
Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln
    290                 295                 300                 
Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val
305                 310                 315                 320 
Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys Val Gln Val
                325                 330                 335     
Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser
            340                 345                 350         
Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro
        355                 360                 365             
Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser
    370                 375                 380                 
Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu
385                 390                 395                 400 
Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp
                405                 410                 415     
Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Lys
            420                 425                 430     


<210> 44
<211> 699
<212> DNA
<213> Homo sapiens

<400> 44
gagcccagag ggcccacaat caagccctgt cctccatgca aatgcccagc acctaacctc 60
ttgggtggac catccgtctt catcttccct ccaaagatca aggatgtact catgatctcc 120
ctgagcccca tagtcacatg tgtggtggtg gatgtgagcg aggatgaccc agatgtccag 180
atcagctggt ttgtgaacaa cgtggaagta cacacagctc agacacaaac ccatagagag 240
gattacaaca gtactctccg ggtggtcagt gccctcccca tccagcacca ggactggatg 300
agtggcaagg agttcaaatg caaggtcaac aacaaagacc tcccagcgcc catcgagaga 360
accatctcaa aacccaaagg gtcagtaaga gctccacagg tatatgtctt gcctccacca 420
gaagaagaga tgactaagaa acaggtcact ctgacctgca tggtcacaga cttcatgcct 480
gaagacattt acgtggagtg gaccaacaac gggaaaacag agctaaacta caagaacact 540
gaaccagtcc tggactctga tggttcttac ttcatgtaca gcaagctgag agtggaaaag 600
aagaactggg tggaaagaaa tagctactcc tgttcagtgg tccacgaggg tctgcacaat 660
caccacacga ctaagagctt ctcccggact ccgggtaaa                        699

<210> 45
<211> 233
<212> PRT
<213> Homo sapiens

<400> 45
Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro
 1               5                  10                  15      
Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys
            20                  25                  30          
Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val
        35                  40                  45              
Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe
    50                  55                  60                  
Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu
65                  70                  75                  80  
Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His
                85                  90                  95      
Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys
            100                 105                 110         
Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser
        115                 120                 125             
Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met
    130                 135                 140                 
Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro
145                 150                 155                 160 
Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn
                165                 170                 175     
Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met
            180                 185                 190         
Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser
        195                 200                 205             
Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr
    210                 215                 220                 
Lys Ser Phe Ser Arg Thr Pro Gly Lys
225                 230             


<210> 46
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 46
gtttcgctca gccaggaaat ccatgccgag ttgagacgct tccgtagact ggagaggctt 60
gtggggcct                                                         69

<210> 47
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 47
tgtgggccct ctgggctcct tgtggatgta tttgtc                           36

<210> 48
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 48
gacaaataca tccacaagga gcccagaggg cccaca                           36

<210> 49
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 49
caaccccaga gctgttttaa ggcgcgcctc tagattattt acccggagtc cggga      55

<210> 50
<211> 76
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 50
caaccccaga gctgttttaa ggcgcgcctc tagattattc catgggcatg tattcttcct 60
tgtggatgta tttgtc                                                 76

<210> 51
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> C-terminal his tag

<400> 51
Gly Ser Gly Gly His His His His His His
 1               5                  10  


<210> 52
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> C-terminal FLAG tag

<400> 52
Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys
 1               5                  10  


<210> 53
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glu-Glu tag

<400> 53
Glu Glu Tyr Met Pro Met Glu
 1               5          


<210> 54
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 54
caaccccaga gctgttttaa ggcgcgcctc tagattagtg atggtgatgg tgatgtccac 60
cagatccctt gtggatgtat ttgtc                                       85

<210> 55
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 55
caaccccaga gctgttttaa ggcgcgcctc tagattactt atcatcatca tccttataat 60
cggatccctt gtggatgtat ttgtc                                       85

<210> 56
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 56
acgaagccca ggtaccagaa agag                                        24

<210> 57
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 57
aaaagcgccg cagccaagag tagg                                        24

<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 58
cgtaagcggt ggcggttttc                                             20

<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 59
tgggcagggc acagtcacag                                             20

<210> 60
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 60
acttgccatt ctgagggagg tagc                                        24

<210> 61
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 61
cacaggtgca gccaactttt agga                                        24

<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 62
gtgggccgct ctaggcacca                                             20

<210> 63
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 63
cggttggcct tagggttcag ggggg                                       25

<210> 64
<211> 2127
<212> DNA
<213> Homo sapiens

<400> 64
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt 60
tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagactgga gaggcttgtg 120
gggcctcagg acgctaccca ctgctctccg ggcctctcct gccgcctctg ggacagtgac 180
atactctgcc tgcctgggga catcgtgcct gctccgggcc ccgtgctggc gcctacgcac 240
ctgcagacag agctggtgct gaggtgccag aaggagaccg actgtgacct ctgtctgcgt 300
gtggctgtcc acttggccgt gcatgggcac tgggaagagc ctgaagatga ggaaaagttt 360
ggaggagcag ctgactcagg ggtggaggag cctaggaatg cctctctcca ggcccaagtc 420
gtgctctcct tccaggccta ccctactgcc cgctgcgtcc tgctggaggt gcaagtgcct 480
gctgcccttg tgcagtttgg tcagtctgtg ggctctgtgg tatatgactg cttcgaggct 540
gccctaggga gtgaggtacg aatctggtcc tatactcagc ccaggtacga gaaggaactc 600
aaccacacac agcagctgcc tgccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agggaggacc cccgcgcaca ccagaacctc 900
tggcaagccg cccgactgcg actgctgacc ctgcagagct ggctgctgga cgcaccgtgc 960
tcgctgcccg cagaagcggc actgtgctgg cgggctccgg gtggggaccc ctgccagcca 1020
ctggtcccac cgctttcctg ggagaacgtc actgtggaca aggttctcga gttcccattg 1080
ctgaaaggcc accctaacct ctgtgttcag gtgaacagct cggagaagct gcagctgcag 1140
gagtgcttgt gggctgactc cctggggcct ctcaaagacg atgtgctact gttggagaca 1200
cgaggccccc aggacaacag atccctctgt gccttggaac ccagtggctg tacttcacta 1260
cccagcaaag cctccacgag ggcagctcgc cttggagagt acttactaca agacctgcag 1320
tcaggccagt gtctgcagct atgggacgat gacttgggag cgctatgggc ctgccccatg 1380
gacaaataca tccacaaggg aggaagtggc ggaggaacag gaagtttggt ccctcgtgga 1440
agcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca 1500
gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 1560
acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 1620
gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 1680
taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 1740
aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1800
aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1860
aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1920
gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1980
tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag 2040
gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 2100
agcctctccc tgtctccggg taaataa                                     2127

<210> 65
<211> 708
<212> PRT
<213> Homo sapiens

<400> 65
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His Cys
        35                  40                  45              
Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys Leu
    50                  55                  60                  
Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr His
65                  70                  75                  80  
Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys Asp
                85                  90                  95      
Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp Glu
            100                 105                 110         
Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly Val
        115                 120                 125             
Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe
    130                 135                 140                 
Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val Pro
145                 150                 155                 160 
Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr Asp
                165                 170                 175     
Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr Thr
            180                 185                 190         
Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
    290                 295                 300                 
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
305                 310                 315                 320 
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
                325                 330                 335     
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
            340                 345                 350         
Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys
        355                 360                 365             
Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp
    370                 375                 380                 
Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr
385                 390                 395                 400 
Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly
                405                 410                 415     
Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly
            420                 425                 430         
Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp
        435                 440                 445             
Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile
    450                 455                 460                 
His Lys Gly Gly Ser Gly Gly Gly Thr Gly Ser Leu Val Pro Arg Gly
465                 470                 475                 480 
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
                485                 490                 495     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            500                 505                 510         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        515                 520                 525             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
    530                 535                 540                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
545                 550                 555                 560 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                565                 570                 575     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
            580                 585                 590         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
        595                 600                 605             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
    610                 615                 620                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
625                 630                 635                 640 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                645                 650                 655     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
            660                 665                 670         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
        675                 680                 685             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    690                 695                 700                 
Ser Pro Gly Lys
705             


<210> 66
<211> 1416
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic insert

<400> 66
agccaggaaa tccatgccga gttgagacgc ttccgtagac tggagaggct tgtggggcct 60
caggacgcta cccactgctc tccgggcctc tcctgccgcc tctgggacag tgacatactc 120
tgcctgcctg gggacatcgt gcctgctccg ggccccgtgc tggcgcctac gcacctgcag 180
acagagctgg tgctgaggtg ccagaaggag accgactgtg acctctgtct gcgtgtggct 240
gtccacttgg ccgtgcatgg gcactgggaa gagcctgaag atgaggaaaa gtttggagga 300
gcagctgact caggggtgga ggagcctagg aatgcctctc tccaggccca agtcgtgctc 360
tccttccagg cctaccctac tgcccgctgc gtcctgctgg aggtgcaagt gcctgctgcc 420
cttgtgcagt ttggtcagtc tgtgggctct gtggtatatg actgcttcga ggctgcccta 480
gggagtgagg tacgaatctg gtcctatact cagcccaggt acgagaagga actcaaccac 540
acacagcagc tgcctgccct gccctggctc aacgtgtcag cagatggtga caacgtgcat 600
ctggttctga atgtctctga ggagcagcac ttcggcctct ccctgtactg gaatcaggtc 660
cagggccccc caaaaccccg gtggcacaaa aacctgactg gaccgcagat cattaccttg 720
aaccacacag acctggttcc ctgcctctgt attcaggtgt ggcctctgga acctgactcc 780
gttaggacga acatctgccc cttcagggag gacccccgcg cacaccagaa cctctggcaa 840
gccgcccgac tgcgactgct gaccctgcag agctggctgc tggacgcacc gtgctcgctg 900
cccgcagaag cggcactgtg ctggcgggct ccgggtgggg acccctgcca gccactggtc 960
ccaccgcttt cctgggagaa cgtcactgtg gacaaggttc tcgagttccc attgctgaaa 1020
ggccacccta acctctgtgt tcaggtgaac agctcggaga agctgcagct gcaggagtgc 1080
ttgtgggctg actccctggg gcctctcaaa gacgatgtgc tactgttgga gacacgaggc 1140
ccccaggaca acagatccct ctgtgccttg gaacccagtg gctgtacttc actacccagc 1200
aaagcctcca cgagggcagc tcgccttgga gagtacttac tacaagacct gcagtcaggc 1260
cagtgtctgc agctatggga cgatgacttg ggagcgctat gggcctgccc catggacaaa 1320
tacatccaca agggaggaag tggcggagga acaggaagtt tggtccctcg tggaagcgac 1380
aaaactcaca catgcccacc gtgcccagca cctgaa                           1416

<210> 67
<211> 2154
<212> DNA
<213> homo sapians

<400> 67
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt 60
tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagactgga gaggcttgtg 120
gggcctcagg acgctaccca ctgctctccg ggcctctcct gccgcctctg ggacagtgac 180
atactctgcc tgcctgggga catcgtgcct gctccgggcc ccgtgctggc gcctacgcac 240
ctgcagacag agctggtgct gaggtgccag aaggagaccg actgtgacct ctgtctgcgt 300
gtggctgtcc acttggccgt gcatgggcac tgggaagagc ctgaagatga ggaaaagttt 360
ggaggagcag ctgactcagg ggtggaggag cctaggaatg cctctctcca ggcccaagtc 420
gtgctctcct tccaggccta ccctactgcc cgctgcgtcc tgctggaggt gcaagtgcct 480
gctgcccttg tgcagtttgg tcagtctgtg ggctctgtgg tatatgactg cttcgaggct 540
gccctaggga gtgaggtacg aatctggtcc tatactcagc ccaggtacga gaaggaactc 600
aaccacacac agcagctgcc tgccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agggaggacc cccgcgcaca ccagaacctc 900
tggcaagccg cccgactgcg actgctgacc ctgcagagct ggctgctgga cgcaccgtgc 960
tcgctgcccg cagaagcggc actgtgctgg cgggctccgg gtggggaccc ctgccagcca 1020
ctggtcccac cgctttcctg ggagaacgtc actgtggaca aggttctcga gttcccattg 1080
ctgaaaggcc accctaacct ctgtgttcag gtgaacagct cggagaagct gcagctgcag 1140
gagtgcttgt gggctgactc cctggggcct ctcaaagacg atgtgctact gttggagaca 1200
cgaggccccc aggacaacag atccctctgt gccttggaac ccagtggctg tacttcacta 1260
cccagcaaag cctccacgag ggcagctcgc cttggagagt acttactaca agacctgcag 1320
tcaggccagt gtctgcagct atgggacgat gacttgggag cgctatgggc ctgccccatg 1380
gacaaataca tccacaaggg aggtgggggc tccggcgggg gtggaagcgg tggaggcggg 1440
tcggggggcg gaggtagtga gcccaaatct tcagacaaaa ctcacacatg cccaccgtgc 1500
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 1560
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 1620
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 1680
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 1740
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 1800
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 1860
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 1920
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 1980
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 2040
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 2100
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       2154

<210> 68
<211> 718
<212> PRT
<213> homosapians

<400> 68
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His Cys
        35                  40                  45              
Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys Leu
    50                  55                  60                  
Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr His
65                  70                  75                  80  
Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys Asp
                85                  90                  95      
Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp Glu
            100                 105                 110         
Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly Val
        115                 120                 125             
Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe
    130                 135                 140                 
Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val Pro
145                 150                 155                 160 
Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr Asp
                165                 170                 175     
Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr Thr
            180                 185                 190         
Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
    290                 295                 300                 
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
305                 310                 315                 320 
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
                325                 330                 335     
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
            340                 345                 350         
Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys
        355                 360                 365             
Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp
    370                 375                 380                 
Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr
385                 390                 395                 400 
Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly
                405                 410                 415     
Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly
            420                 425                 430         
Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp
        435                 440                 445             
Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile
    450                 455                 460                 
His Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
465                 470                 475                 480 
Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr
                485                 490                 495     
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
            500                 505                 510         
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
        515                 520                 525             
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
    530                 535                 540                 
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
545                 550                 555                 560 
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
                565                 570                 575     
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
            580                 585                 590         
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
        595                 600                 605             
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
    610                 615                 620                 
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
625                 630                 635                 640 
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                645                 650                 655     
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
            660                 665                 670         
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
        675                 680                 685             
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
    690                 695                 700                 
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
705                 710                 715             


<210> 69
<211> 2052
<212> DNA
<213> homo sapians

<400> 69
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgccc tgccctggct caacgtgtca 600
gcagatggtg acaacgtgca tctggttctg aatgtctctg aggagcagca cttcggcctc 660
tccctgtact ggaatcaggt ccagggcccc ccaaaacccc ggtggcacaa aaacctgact 720
ggaccgcaga tcattacctt gaaccacaca gacctggttc cctgcctctg tattcaggtg 780
tggcctctgg aacctgactc cgttaggacg aacatctgcc ccttcaggga ggacccccgc 840
gcacaccaga acctctggca agccgcccga ctgcgactgc tgaccctgca gagctggctg 900
ctggacgcac cgtgctcgct gcccgcagaa gcggcactgt gctggcgggc tccgggtggg 960
gacccctgcc agccactggt cccaccgctt tcctgggaga acgtcactgt ggacaaggtt 1020
ctcgagttcc cattgctgaa aggccaccct aacctctgtg ttcaggtgaa cagctcggag 1080
aagctgcagc tgcaggagtg cttgtgggct gactccctgg ggcctctcaa agacgatgtg 1140
ctactgttgg agacacgagg cccccaggac aacagatccc tctgtgcctt ggaacccagt 1200
ggctgtactt cactacccag caaagcctcc acgagggcag ctcgccttgg agagtactta 1260
ctacaagacc tgcagtcagg ccagtgtctg cagctatggg acgatgactt gggagcgcta 1320
tgggcctgcc ccatggacaa atacatccac aaggagccca aatcttcaga caaaactcac 1380
acatgcccac cgtgcccagc acctgaagcc gagggggcac cgtcagtctt cctcttcccc 1440
ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 1500
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 1560
cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 1620
gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 1680
aacaaagccc tcccatcctc catcgagaaa accatctcca aagccaaagg gcagccccga 1740
gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1800
ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1860
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc 1920
ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1980
tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 2040
ccgggtaaat aa                                                     2052

<210> 70
<211> 683
<212> PRT
<213> homo sapians

<400> 70
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu
        195                 200                 205             
Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp
    210                 215                 220                 
Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr
225                 230                 235                 240 
Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu
                245                 250                 255     
Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile
            260                 265                 270         
Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala
        275                 280                 285             
Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro
    290                 295                 300                 
Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly
305                 310                 315                 320 
Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr
                325                 330                 335     
Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu
            340                 345                 350         
Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu
        355                 360                 365             
Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu
    370                 375                 380                 
Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser
385                 390                 395                 400 
Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu
                405                 410                 415     
Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu
            420                 425                 430         
Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr
        435                 440                 445             
Ile His Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
    450                 455                 460                 
Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro
465                 470                 475                 480 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
                485                 490                 495     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
            500                 505                 510         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
        515                 520                 525             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
    530                 535                 540                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
545                 550                 555                 560 
Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
                565                 570                 575     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
            580                 585                 590         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
        595                 600                 605             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
    610                 615                 620                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
625                 630                 635                 640 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                645                 650                 655     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
            660                 665                 670         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        675                 680             


<210> 71
<211> 2130
<212> DNA
<213> Artificial Sequence

<220> 
<223> Murine signal peptide and exons 1-6 of murine
      IL-17RA, exons 8-16 of human IL-17RC, linker and
      Fc10

<400> 71
atggcgattc ggcgctgctg gccacgggtc gtccccgggc ccgcgctggg atggctgctt 60
ctgctgctga acgttctggc cccgggccgc gcctccccgc gcctcctcga cttcccggct 120
ccggtctgcg cgcaggaggg gctgagctgc agagtcaaga atagtacttg tctggatgac 180
agctggatcc accccaaaaa cctgaccccg tcttccccaa aaaacatcta tatcaatctt 240
agtgtttcct ctacccagca cggagaatta gtccctgtgt tgcatgttga gtggaccctg 300
cagacagatg ccagcatcct gtacctcgag ggtgcagagc tgtccgtcct gcagctgaac 360
accaatgagc ggctgtgtgt caagttccag tttctgtcca tgctgcagca tcaccgtaag 420
cggtggcggt tttccttcag ccactttgtg gtagatcctg gccaggagta tgaagtgact 480
gttcaccacc tgccgaagcc catccctgat ggggacccaa accacaaatc caagatcatc 540
tttgtgcctg actgtgagga cagcaagatg aagatgacta cctcatgcgt gagctcagcc 600
ctgccctggc tcaacgtgtc agcagatggt gacaacgtgc atctggttct gaatgtctct 660
gaggagcagc acttcggcct ctccctgtac tggaatcagg tccagggccc cccaaaaccc 720
cggtggcaca aaaacctgac tggaccgcag atcattacct tgaaccacac agacctggtt 780
ccctgcctct gtattcaggt gtggcctctg gaacctgact ccgttaggac gaacatctgc 840
cccttcaggg aggacccccg cgcacaccag aacctctggc aagccgcccg actgcgactg 900
ctgaccctgc agagctggct gctggacgca ccgtgctcgc tgcccgcaga agcggcactg 960
tgctggcggg ctccgggtgg ggacccctgc cagccactgg tcccaccgct ttcctgggag 1020
aacgtcactg tggacaaggt tctcgagttc ccattgctga aaggccaccc taacctctgt 1080
gttcaggtga acagctcgga gaagctgcag ctgcaggagt gcttgtgggc tgactccctg 1140
gggcctctca aagacgatgt gctactgttg gagacacgag gcccccagga caacagatcc 1200
ctctgtgcct tggaacccag tggctgtact tcactaccca gcaaagcctc cacgagggca 1260
gctcgccttg gagagtactt actacaagac ctgcagtcag gccagtgtct gcagctatgg 1320
gacgatgact tgggagcgct atgggcctgc cccatggaca aatacatcca caagggaggt 1380
gggggctccg gcgggggtgg aagcggtgga ggcgggtcgg ggggcggagg tagtgagccc 1440
aaatcttcag acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 1500
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 1560
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 1620
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 1680
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 1740
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 1800
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 1860
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 1920
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 1980
ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 2040
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 2100
cagaagagcc tctccctgtc tccgggtaaa                                  2130

<210> 72
<211> 710
<212> PRT
<213> Artificial Sequence

<220> 
<223> Murine signal peptide and exons 1-6 of murine
      IL-17RA, exons 8-16 of human IL-17RC, linker and
      Fc10

<400> 72
Met Ala Ile Arg Arg Cys Trp Pro Arg Val Val Pro Gly Pro Ala Leu
 1               5                  10                  15      
Gly Trp Leu Leu Leu Leu Leu Asn Val Leu Ala Pro Gly Arg Ala Ser
            20                  25                  30          
Pro Arg Leu Leu Asp Phe Pro Ala Pro Val Cys Ala Gln Glu Gly Leu
        35                  40                  45              
Ser Cys Arg Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His
    50                  55                  60                  
Pro Lys Asn Leu Thr Pro Ser Ser Pro Lys Asn Ile Tyr Ile Asn Leu
65                  70                  75                  80  
Ser Val Ser Ser Thr Gln His Gly Glu Leu Val Pro Val Leu His Val
                85                  90                  95      
Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala
            100                 105                 110         
Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Lys
        115                 120                 125             
Phe Gln Phe Leu Ser Met Leu Gln His His Arg Lys Arg Trp Arg Phe
    130                 135                 140                 
Ser Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val Thr
145                 150                 155                 160 
Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Lys
                165                 170                 175     
Ser Lys Ile Ile Phe Val Pro Asp Cys Glu Asp Ser Lys Met Lys Met
            180                 185                 190         
Thr Thr Ser Cys Val Ser Ser Ala Leu Pro Trp Leu Asn Val Ser Ala
        195                 200                 205             
Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His
    210                 215                 220                 
Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro
225                 230                 235                 240 
Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His
                245                 250                 255     
Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro
            260                 265                 270         
Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala
        275                 280                 285             
His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln
    290                 295                 300                 
Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu
305                 310                 315                 320 
Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro
                325                 330                 335     
Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu
            340                 345                 350         
Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys
        355                 360                 365             
Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys
    370                 375                 380                 
Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser
385                 390                 395                 400 
Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala
                405                 410                 415     
Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln
            420                 425                 430         
Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp
        435                 440                 445             
Ala Cys Pro Met Asp Lys Tyr Ile His Lys Gly Gly Gly Gly Ser Gly
    450                 455                 460                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro
465                 470                 475                 480 
Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
                485                 490                 495     
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
            500                 505                 510         
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
        515                 520                 525             
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
    530                 535                 540                 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
545                 550                 555                 560 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
                565                 570                 575     
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
            580                 585                 590         
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
        595                 600                 605             
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
    610                 615                 620                 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
625                 630                 635                 640 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
                645                 650                 655     
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
            660                 665                 670         
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
        675                 680                 685             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
    690                 695                 700                 
Ser Leu Ser Pro Gly Lys
705                 710 


<210> 73
<211> 1638
<212> DNA
<213> Artificial Sequence

<220> 
<223> otPA (optimized tissue Plasminogen Activator)
      signal peptide and exons 8-16 of human IL-17RC,
      linker and Fc10

<400> 73
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt 60
tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagagccct gccctggctc 120
aacgtgtcag cagatggtga caacgtgcat ctggttctga atgtctctga ggagcagcac 180
ttcggcctct ccctgtactg gaatcaggtc cagggccccc caaaaccccg gtggcacaaa 240
aacctgactg gaccgcagat cattaccttg aaccacacag acctggttcc ctgcctctgt 300
attcaggtgt ggcctctgga acctgactcc gttaggacga acatctgccc cttcagggag 360
gacccccgcg cacaccagaa cctctggcaa gccgcccgac tgcgactgct gaccctgcag 420
agctggctgc tggacgcacc gtgctcgctg cccgcagaag cggcactgtg ctggcgggct 480
ccgggtgggg acccctgcca gccactggtc ccaccgcttt cctgggagaa cgtcactgtg 540
gacaaggttc tcgagttccc attgctgaaa ggccacccta acctctgtgt tcaggtgaac 600
agctcggaga agctgcagct gcaggagtgc ttgtgggctg actccctggg gcctctcaaa 660
gacgatgtgc tactgttgga gacacgaggc ccccaggaca acagatccct ctgtgccttg 720
gaacccagtg gctgtacttc actacccagc aaagcctcca cgagggcagc tcgccttgga 780
gagtacttac tacaagacct gcagtcaggc cagtgtctgc agctatggga cgatgacttg 840
ggagcgctat gggcctgccc catggacaaa tacatccaca agggaggtgg gggctccggc 900
gggggtggaa gcggtggagg cgggtcgggg ggcggaggta gtgagcccaa atcttcagac 960
aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc 1020
ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1080
gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1140
gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 1200
gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1260
aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1320
cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac 1380
caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1440
gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1500
ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac 1560
gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 1620
tccctgtctc cgggtaaa                                               1638

<210> 74
<211> 546
<212> PRT
<213> Artificial Sequence

<220> 
<223> otPA (optimized tissue Plasminogen Activator)
      signal peptide and exons 8-16 of human IL-17RC,
      linker and Fc10

<400> 74
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn
        35                  40                  45              
Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser
    50                  55                  60                  
Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys
65                  70                  75                  80  
Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val
                85                  90                  95      
Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg
            100                 105                 110         
Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu
        115                 120                 125             
Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu
    130                 135                 140                 
Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala
145                 150                 155                 160 
Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu
                165                 170                 175     
Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His
            180                 185                 190         
Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln
        195                 200                 205             
Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu
    210                 215                 220                 
Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu
225                 230                 235                 240 
Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala
                245                 250                 255     
Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys
            260                 265                 270         
Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met
        275                 280                 285             
Asp Lys Tyr Ile His Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    290                 295                 300                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp
305                 310                 315                 320 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
                325                 330                 335     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
            340                 345                 350         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
        355                 360                 365             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
    370                 375                 380                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
385                 390                 395                 400 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
                405                 410                 415     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
            420                 425                 430         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
        435                 440                 445             
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
    450                 455                 460                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
465                 470                 475                 480 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
                485                 490                 495     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
            500                 505                 510         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
        515                 520                 525             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
    530                 535                 540                 
Gly Lys
545     


<210> 75
<211> 622
<212> DNA
<213> homo sapians

<400> 75
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg gg                                          622

<210> 76
<211> 207
<212> PRT
<213> homo sapians

<400> 76
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp
        195                 200                 205         


<210> 77
<211> 1318
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-7 of human
      IL-17RC, and Fc5

<400> 77
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg gggagcccaa atcttcagac aaaactcaca catgcccacc 660
gtgcccagca cctgaagccg agggggcacc gtcagtcttc ctcttccccc caaaacccaa 720
ggacaccctc atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca 780
cgaagaccct gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa 840
gacaaagccg cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt 900
cctgcaccag gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct 960
cccatcctcc atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt 1020
gtacaccctg cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct 1080
ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga 1140
gaacaactac aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag 1200
caagctcacc gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat 1260
gcatgaggct ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa   1318

<210> 78
<211> 439
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-7 of human
      IL-17RC, and Fc5

<400> 78
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Glu
        195                 200                 205             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
    210                 215                 220                 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
225                 230                 235                 240 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
                245                 250                 255     
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
            260                 265                 270         
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
        275                 280                 285             
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
    290                 295                 300                 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
305                 310                 315                 320 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
                325                 330                 335     
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
            340                 345                 350         
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
        355                 360                 365             
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
    370                 375                 380                 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
385                 390                 395                 400 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
                405                 410                 415     
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
            420                 425                 430         
Leu Ser Leu Ser Pro Gly Lys
        435                 


<210> 79
<211> 762
<212> DNA
<213> homo sapians

<400> 79
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tg                    762

<210> 80
<211> 254
<212> PRT
<213> homo sapians

<400> 80
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu
                245                 250                 


<210> 81
<211> 1458
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-8 of human
      IL-17RC, and Fc5

<400> 81
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tggagcccaa atcttcagac 780
aaaactcaca catgcccacc gtgcccagca cctgaagccg agggggcacc gtcagtcttc 840
ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 900
gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 960
gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 1020
gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1080
aaggtctcca acaaagccct cccatcctcc atcgagaaaa ccatctccaa agccaaaggg 1140
cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac 1200
caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1260
gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1320
ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac 1380
gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 1440
tccctgtctc cgggtaaa                                               1458

<210> 82
<211> 486
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-8 of human
      IL-17RC, and Fc5

<400> 82
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Glu Pro
                245                 250                 255     
Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
            260                 265                 270         
Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        275                 280                 285             
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    290                 295                 300                 
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
305                 310                 315                 320 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
                325                 330                 335     
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
            340                 345                 350         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
        355                 360                 365             
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
    370                 375                 380                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
385                 390                 395                 400 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                405                 410                 415     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            420                 425                 430         
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        435                 440                 445             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    450                 455                 460                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
465                 470                 475                 480 
Ser Leu Ser Pro Gly Lys
                485     


<210> 83
<211> 822
<212> DNA
<213> homo sapians

<400> 83
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc ag                    822

<210> 84
<211> 274
<212> PRT
<213> homo sapians

<400> 84
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln
        


<210> 85
<211> 1518
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-9 of human
      IL-17RC, and Fc5

<400> 85
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggagcccaa atcttcagac 840
aaaactcaca catgcccacc gtgcccagca cctgaagccg agggggcacc gtcagtcttc 900
ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 960
gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1020
gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 1080
gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1140
aaggtctcca acaaagccct cccatcctcc atcgagaaaa ccatctccaa agccaaaggg 1200
cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac 1260
caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1320
gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1380
ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac 1440
gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 1500
tccctgtctc cgggtaaa                                               1518

<210> 86
<211> 506
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-9 of human
      IL-17RC, and Fc5

<400> 86
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
        275                 280                 285             
Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
    290                 295                 300                 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
305                 310                 315                 320 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
                325                 330                 335     
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
            340                 345                 350         
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
        355                 360                 365             
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
    370                 375                 380                 
Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
385                 390                 395                 400 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
                405                 410                 415     
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
            420                 425                 430         
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
        435                 440                 445             
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
    450                 455                 460                 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
465                 470                 475                 480 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
                485                 490                 495     
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            500                 505     


<210> 87
<211> 873
<212> DNA
<213> homo sapians

<400> 87
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agg                              873

<210> 88
<211> 291
<212> PRT
<213> homo sapians

<400> 88
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg
    290     


<210> 89
<211> 1569
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-10 of human
      IL-17RC, and Fc5

<400> 89
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agggagccca aatcttcaga caaaactcac 900
acatgcccac cgtgcccagc acctgaagcc gagggggcac cgtcagtctt cctcttcccc 960
ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 1020
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 1080
cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 1140
gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 1200
aacaaagccc tcccatcctc catcgagaaa accatctcca aagccaaagg gcagccccga 1260
gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1320
ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1380
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc 1440
ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1500
tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1560
ccgggtaaa                                                         1569

<210> 90
<211> 523
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-10 of human
      IL-17RC, and Fc5

<400> 90
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
    290                 295                 300                 
Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro
305                 310                 315                 320 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
                325                 330                 335     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
            340                 345                 350         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
        355                 360                 365             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
    370                 375                 380                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
385                 390                 395                 400 
Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
                405                 410                 415     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
            420                 425                 430         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
        435                 440                 445             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
    450                 455                 460                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
465                 470                 475                 480 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                485                 490                 495     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
            500                 505                 510         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        515                 520             


<210> 91
<211> 1059
<212> DNA
<213> homo sapians

<400> 91
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agggaggacc cccgcgcaca ccagaacctc 900
tggcaagccg cccgactgcg actgctgacc ctgcagagct ggctgctgga cgcaccgtgc 960
tcgctgcccg cagaagcggc actgtgctgg cgggctccgg gtggggaccc ctgccagcca 1020
ctggtcccac cgctttcctg ggagaacgtc actgtggac                        1059

<210> 92
<211> 353
<212> PRT
<213> homo sapians

<400> 92
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
    290                 295                 300                 
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
305                 310                 315                 320 
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
                325                 330                 335     
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
            340                 345                 350         
Asp
    


<210> 93
<211> 1755
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-11 of human
      IL-17RC, and Fc5

<400> 93
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agggaggacc cccgcgcaca ccagaacctc 900
tggcaagccg cccgactgcg actgctgacc ctgcagagct ggctgctgga cgcaccgtgc 960
tcgctgcccg cagaagcggc actgtgctgg cgggctccgg gtggggaccc ctgccagcca 1020
ctggtcccac cgctttcctg ggagaacgtc actgtggacg agcccaaatc ttcagacaaa 1080
actcacacat gcccaccgtg cccagcacct gaagccgagg gggcaccgtc agtcttcctc 1140
ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 1200
gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg 1260
gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg 1320
gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag 1380
gtctccaaca aagccctccc atcctccatc gagaaaacca tctccaaagc caaagggcag 1440
ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 1500
gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag 1560
agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 1620
tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 1680
ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc 1740
ctgtctccgg gtaaa                                                  1755

<210> 94
<211> 585
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-11 of human
      IL-17RC, and Fc5

<400> 94
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
    290                 295                 300                 
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
305                 310                 315                 320 
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
                325                 330                 335     
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
            340                 345                 350         
Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
        355                 360                 365             
Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys
    370                 375                 380                 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
385                 390                 395                 400 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
                405                 410                 415     
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
            420                 425                 430         
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
        435                 440                 445             
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
    450                 455                 460                 
Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
465                 470                 475                 480 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
                485                 490                 495     
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
            500                 505                 510         
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
        515                 520                 525             
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
    530                 535                 540                 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
545                 550                 555                 560 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                565                 570                 575     
Lys Ser Leu Ser Leu Ser Pro Gly Lys
            580                 585 


<210> 95
<211> 303
<212> DNA
<213> homo sapians

<400> 95
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
gactccctgg ggcctctcaa agacgatgtg ctactgttgg agacacgagg cccccaggac 120
aacagatccc tctgtgcctt ggaacccagt ggctgtactt cactacccag caaagcctcc 180
acgagggcag ctcgccttgg agagtactta ctacaagacc tgcagtcagg ccagtgtctg 240
cagctatggg acgatgactt gggagcgcta tgggcctgcc ccatggacaa atacatccac 300
aag                                                               303

<210> 96
<211> 101
<212> PRT
<213> homo sapians

<400> 96
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu
            20                  25                  30          
Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu
        35                  40                  45              
Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala
    50                  55                  60                  
Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu
65                  70                  75                  80  
Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp
                85                  90                  95      
Lys Tyr Ile His Lys
            100     


<210> 97
<211> 999
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 14-16 of human
      IL-17RC, and Fc5

<400> 97
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
gactccctgg ggcctctcaa agacgatgtg ctactgttgg agacacgagg cccccaggac 120
aacagatccc tctgtgcctt ggaacccagt ggctgtactt cactacccag caaagcctcc 180
acgagggcag ctcgccttgg agagtactta ctacaagacc tgcagtcagg ccagtgtctg 240
cagctatggg acgatgactt gggagcgcta tgggcctgcc ccatggacaa atacatccac 300
aaggagccca aatcttcaga caaaactcac acatgcccac cgtgcccagc acctgaagcc 360
gagggggcac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc 420
cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag 480
ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag 540
cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg 600
aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccatcctc catcgagaaa 660
accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 720
cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc 780
agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg 840
cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag 900
agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac 960
cactacacgc agaagagcct ctccctgtct ccgggtaaa                        999

<210> 98
<211> 333
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 14-16 of human
      IL-17RC, and Fc5

<400> 98
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu
            20                  25                  30          
Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu
        35                  40                  45              
Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala
    50                  55                  60                  
Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu
65                  70                  75                  80  
Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp
                85                  90                  95      
Lys Tyr Ile His Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys
            100                 105                 110         
Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu
        115                 120                 125             
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
    130                 135                 140                 
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
145                 150                 155                 160 
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
                165                 170                 175     
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
            180                 185                 190         
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
        195                 200                 205             
Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
    210                 215                 220                 
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
225                 230                 235                 240 
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
                245                 250                 255     
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
            260                 265                 270         
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
        275                 280                 285             
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
    290                 295                 300                 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
305                 310                 315                 320 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330             


<210> 99
<211> 585
<212> DNA
<213> homo sapians

<400> 99
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
gaggaccccc gcgcacacca gaacctctgg caagccgccc gactgcgact gctgaccctg 120
cagagctggc tgctggacgc accgtgctcg ctgcccgcag aagcggcact gtgctggcgg 180
gctccgggtg gggacccctg ccagccactg gtcccaccgc tttcctggga gaacgtcact 240
gtggacaagg ttctcgagtt cccattgctg aaaggccacc ctaacctctg tgttcaggtg 300
aacagctcgg agaagctgca gctgcaggag tgcttgtggg ctgactccct ggggcctctc 360
aaagacgatg tgctactgtt ggagacacga ggcccccagg acaacagatc cctctgtgcc 420
ttggaaccca gtggctgtac ttcactaccc agcaaagcct ccacgagggc agctcgcctt 480
ggagagtact tactacaaga cctgcagtca ggccagtgtc tgcagctatg ggacgatgac 540
ttgggagcgc tatgggcctg ccccatggac aaatacatcc acaag                 585

<210> 100
<211> 195
<212> PRT
<213> homo sapians

<400> 100
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala
            20                  25                  30          
Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro
        35                  40                  45              
Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly
    50                  55                  60                  
Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr
65                  70                  75                  80  
Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu
                85                  90                  95      
Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu
            100                 105                 110         
Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu
        115                 120                 125             
Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser
    130                 135                 140                 
Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu
145                 150                 155                 160 
Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu
                165                 170                 175     
Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr
            180                 185                 190         
Ile His Lys
        195 


<210> 101
<211> 1281
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 11-16 of human
      IL-17RC, and Fc5

<400> 101
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
gaggaccccc gcgcacacca gaacctctgg caagccgccc gactgcgact gctgaccctg 120
cagagctggc tgctggacgc accgtgctcg ctgcccgcag aagcggcact gtgctggcgg 180
gctccgggtg gggacccctg ccagccactg gtcccaccgc tttcctggga gaacgtcact 240
gtggacaagg ttctcgagtt cccattgctg aaaggccacc ctaacctctg tgttcaggtg 300
aacagctcgg agaagctgca gctgcaggag tgcttgtggg ctgactccct ggggcctctc 360
aaagacgatg tgctactgtt ggagacacga ggcccccagg acaacagatc cctctgtgcc 420
ttggaaccca gtggctgtac ttcactaccc agcaaagcct ccacgagggc agctcgcctt 480
ggagagtact tactacaaga cctgcagtca ggccagtgtc tgcagctatg ggacgatgac 540
ttgggagcgc tatgggcctg ccccatggac aaatacatcc acaaggagcc caaatcttca 600
gacaaaactc acacatgccc accgtgccca gcacctgaag ccgagggggc accgtcagtc 660
ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 720
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 780
ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 840
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 900
tgcaaggtct ccaacaaagc cctcccatcc tccatcgaga aaaccatctc caaagccaaa 960
gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag 1020
aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1080
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1140
gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg 1200
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 1260
ctctccctgt ctccgggtaa a                                           1281

<210> 102
<211> 427
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 11-16 of human
      IL-17RC, and Fc5

<400> 102
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala
            20                  25                  30          
Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro
        35                  40                  45              
Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly
    50                  55                  60                  
Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr
65                  70                  75                  80  
Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu
                85                  90                  95      
Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu
            100                 105                 110         
Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu
        115                 120                 125             
Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser
    130                 135                 140                 
Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu
145                 150                 155                 160 
Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu
                165                 170                 175     
Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr
            180                 185                 190         
Ile His Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
        195                 200                 205             
Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro
    210                 215                 220                 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
225                 230                 235                 240 
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
                245                 250                 255     
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
            260                 265                 270         
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
        275                 280                 285             
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
    290                 295                 300                 
Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
305                 310                 315                 320 
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
                325                 330                 335     
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            340                 345                 350         
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        355                 360                 365             
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    370                 375                 380                 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
385                 390                 395                 400 
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                405                 410                 415     
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            420                 425         


<210> 103
<211> 882
<212> DNA
<213> homo sapians

<400> 103
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
gactgcaggg ggctcgaagt ctggaacagc atcccgagct gctgggccct gccctggctc 120
aacgtgtcag cagatggtga caacgtgcat ctggttctga atgtctctga ggagcagcac 180
ttcggcctct ccctgtactg gaatcaggtc cagggccccc caaaaccccg gtggcacaaa 240
aacctgactg gaccgcagat cattaccttg aaccacacag acctggttcc ctgcctctgt 300
attcaggtgt ggcctctgga acctgactcc gttaggacga acatctgccc cttcagggag 360
gacccccgcg cacaccagaa cctctggcaa gccgcccgac tgcgactgct gaccctgcag 420
agctggctgc tggacgcacc gtgctcgctg cccgcagaag cggcactgtg ctggcgggct 480
ccgggtgggg acccctgcca gccactggtc ccaccgcttt cctgggagaa cgtcactgtg 540
gacaaggttc tcgagttccc attgctgaaa ggccacccta acctctgtgt tcaggtgaac 600
agctcggaga agctgcagct gcaggagtgc ttgtgggctg actccctggg gcctctcaaa 660
gacgatgtgc tactgttgga gacacgaggc ccccaggaca acagatccct ctgtgccttg 720
gaacccagtg gctgtacttc actacccagc aaagcctcca cgagggcagc tcgccttgga 780
gagtacttac tacaagacct gcagtcaggc cagtgtctgc agctatggga cgatgacttg 840
ggagcgctat gggcctgccc catggacaaa tacatccaca ag                    882

<210> 104
<211> 294
<212> PRT
<213> homo sapians

<400> 104
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro
            20                  25                  30          
Ser Cys Trp Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn
        35                  40                  45              
Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser
    50                  55                  60                  
Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys
65                  70                  75                  80  
Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val
                85                  90                  95      
Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg
            100                 105                 110         
Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu
        115                 120                 125             
Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu
    130                 135                 140                 
Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala
145                 150                 155                 160 
Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu
                165                 170                 175     
Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His
            180                 185                 190         
Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln
        195                 200                 205             
Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu
    210                 215                 220                 
Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu
225                 230                 235                 240 
Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala
                245                 250                 255     
Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys
            260                 265                 270         
Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met
        275                 280                 285             
Asp Lys Tyr Ile His Lys
    290                 


<210> 105
<211> 1578
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 7-16 of human
      IL-17RC, and Fc5

<400> 105
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
gactgcaggg ggctcgaagt ctggaacagc atcccgagct gctgggccct gccctggctc 120
aacgtgtcag cagatggtga caacgtgcat ctggttctga atgtctctga ggagcagcac 180
ttcggcctct ccctgtactg gaatcaggtc cagggccccc caaaaccccg gtggcacaaa 240
aacctgactg gaccgcagat cattaccttg aaccacacag acctggttcc ctgcctctgt 300
attcaggtgt ggcctctgga acctgactcc gttaggacga acatctgccc cttcagggag 360
gacccccgcg cacaccagaa cctctggcaa gccgcccgac tgcgactgct gaccctgcag 420
agctggctgc tggacgcacc gtgctcgctg cccgcagaag cggcactgtg ctggcgggct 480
ccgggtgggg acccctgcca gccactggtc ccaccgcttt cctgggagaa cgtcactgtg 540
gacaaggttc tcgagttccc attgctgaaa ggccacccta acctctgtgt tcaggtgaac 600
agctcggaga agctgcagct gcaggagtgc ttgtgggctg actccctggg gcctctcaaa 660
gacgatgtgc tactgttgga gacacgaggc ccccaggaca acagatccct ctgtgccttg 720
gaacccagtg gctgtacttc actacccagc aaagcctcca cgagggcagc tcgccttgga 780
gagtacttac tacaagacct gcagtcaggc cagtgtctgc agctatggga cgatgacttg 840
ggagcgctat gggcctgccc catggacaaa tacatccaca aggagcccaa atcttcagac 900
aaaactcaca catgcccacc gtgcccagca cctgaagccg agggggcacc gtcagtcttc 960
ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1020
gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1080
gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 1140
gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1200
aaggtctcca acaaagccct cccatcctcc atcgagaaaa ccatctccaa agccaaaggg 1260
cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac 1320
caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1380
gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1440
ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac 1500
gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 1560
tccctgtctc cgggtaaa                                               1578

<210> 106
<211> 526
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 7-16 of human
      IL-17RC, and Fc5

<400> 106
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro
            20                  25                  30          
Ser Cys Trp Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn
        35                  40                  45              
Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser
    50                  55                  60                  
Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys
65                  70                  75                  80  
Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val
                85                  90                  95      
Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg
            100                 105                 110         
Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu
        115                 120                 125             
Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu
    130                 135                 140                 
Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala
145                 150                 155                 160 
Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu
                165                 170                 175     
Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His
            180                 185                 190         
Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln
        195                 200                 205             
Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu
    210                 215                 220                 
Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu
225                 230                 235                 240 
Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala
                245                 250                 255     
Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys
            260                 265                 270         
Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met
        275                 280                 285             
Asp Lys Tyr Ile His Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr
    290                 295                 300                 
Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe
305                 310                 315                 320 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
                325                 330                 335     
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
            340                 345                 350         
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
        355                 360                 365             
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
    370                 375                 380                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
385                 390                 395                 400 
Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser
                405                 410                 415     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
            420                 425                 430         
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
        435                 440                 445             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
    450                 455                 460                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
465                 470                 475                 480 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                485                 490                 495     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
            500                 505                 510         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        515                 520                 525     


<210> 107
<211> 864
<212> DNA
<213> homo sapians

<400> 107
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggactccctg gggcctctca aagacgatgt gctactgttg 660
gagacacgag gcccccagga caacagatcc ctctgtgcct tggaacccag tggctgtact 720
tcactaccca gcaaagcctc cacgagggca gctcgccttg gagagtactt actacaagac 780
ctgcagtcag gccagtgtct gcagctatgg gacgatgact tgggagcgct atgggcctgc 840
cccatggaca aatacatcca caag                                        864

<210> 108
<211> 288
<212> PRT
<213> homo sapians

<400> 108
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Asp
        195                 200                 205             
Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg Gly
    210                 215                 220                 
Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr
225                 230                 235                 240 
Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr
                245                 250                 255     
Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp
            260                 265                 270         
Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Lys
        275                 280                 285             


<210> 109
<211> 1560
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-7 and 14-16 of
      human IL-17RC, and Fc5

<400> 109
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggactccctg gggcctctca aagacgatgt gctactgttg 660
gagacacgag gcccccagga caacagatcc ctctgtgcct tggaacccag tggctgtact 720
tcactaccca gcaaagcctc cacgagggca gctcgccttg gagagtactt actacaagac 780
ctgcagtcag gccagtgtct gcagctatgg gacgatgact tgggagcgct atgggcctgc 840
cccatggaca aatacatcca caaggagccc aaatcttcag acaaaactca cacatgccca 900
ccgtgcccag cacctgaagc cgagggggca ccgtcagtct tcctcttccc cccaaaaccc 960
aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 1020
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 1080
aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 1140
gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 1200
ctcccatcct ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 1260
gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc 1320
ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 1380
gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac 1440
agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg 1500
atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa 1560


<210> 110
<211> 520
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-7 and 14-16 of
      human IL-17RC, and Fc5

<400> 110
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Asp
        195                 200                 205             
Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg Gly
    210                 215                 220                 
Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr
225                 230                 235                 240 
Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr
                245                 250                 255     
Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp
            260                 265                 270         
Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Lys
        275                 280                 285             
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
    290                 295                 300                 
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
305                 310                 315                 320 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                325                 330                 335     
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
            340                 345                 350         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
        355                 360                 365             
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
    370                 375                 380                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
385                 390                 395                 400 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
                405                 410                 415     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
            420                 425                 430         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
        435                 440                 445             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
    450                 455                 460                 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
465                 470                 475                 480 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
                485                 490                 495     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
            500                 505                 510         
Ser Leu Ser Leu Ser Pro Gly Lys
        515                 520 


<210> 111
<211> 1146
<212> DNA
<213> homo sapians

<400> 111
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggaggacccc cgcgcacacc agaacctctg gcaagccgcc 660
cgactgcgac tgctgaccct gcagagctgg ctgctggacg caccgtgctc gctgcccgca 720
gaagcggcac tgtgctggcg ggctccgggt ggggacccct gccagccact ggtcccaccg 780
ctttcctggg agaacgtcac tgtggacaag gttctcgagt tcccattgct gaaaggccac 840
cctaacctct gtgttcaggt gaacagctcg gagaagctgc agctgcagga gtgcttgtgg 900
gctgactccc tggggcctct caaagacgat gtgctactgt tggagacacg aggcccccag 960
gacaacagat ccctctgtgc cttggaaccc agtggctgta cttcactacc cagcaaagcc 1020
tccacgaggg cagctcgcct tggagagtac ttactacaag acctgcagtc aggccagtgt 1080
ctgcagctat gggacgatga cttgggagcg ctatgggcct gccccatgga caaatacatc 1140
cacaag                                                            1146

<210> 112
<211> 382
<212> PRT
<213> homo sapians

<400> 112
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Glu
        195                 200                 205             
Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu
    210                 215                 220                 
Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala
225                 230                 235                 240 
Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro
                245                 250                 255     
Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu
            260                 265                 270         
Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn
        275                 280                 285             
Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu
    290                 295                 300                 
Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln
305                 310                 315                 320 
Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu
                325                 330                 335     
Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu
            340                 345                 350         
Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu
        355                 360                 365             
Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Lys
    370                 375                 380         


<210> 113
<211> 1842
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-7 and 11-16 of
      human IL-17RC, and Fc5

<400> 113
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggaggacccc cgcgcacacc agaacctctg gcaagccgcc 660
cgactgcgac tgctgaccct gcagagctgg ctgctggacg caccgtgctc gctgcccgca 720
gaagcggcac tgtgctggcg ggctccgggt ggggacccct gccagccact ggtcccaccg 780
ctttcctggg agaacgtcac tgtggacaag gttctcgagt tcccattgct gaaaggccac 840
cctaacctct gtgttcaggt gaacagctcg gagaagctgc agctgcagga gtgcttgtgg 900
gctgactccc tggggcctct caaagacgat gtgctactgt tggagacacg aggcccccag 960
gacaacagat ccctctgtgc cttggaaccc agtggctgta cttcactacc cagcaaagcc 1020
tccacgaggg cagctcgcct tggagagtac ttactacaag acctgcagtc aggccagtgt 1080
ctgcagctat gggacgatga cttgggagcg ctatgggcct gccccatgga caaatacatc 1140
cacaaggagc ccaaatcttc agacaaaact cacacatgcc caccgtgccc agcacctgaa 1200
gccgaggggg caccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc 1260
tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc 1320
aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag 1380
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg 1440
ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccatc ctccatcgag 1500
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca 1560
tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat 1620
cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc 1680
acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac 1740
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac 1800
aaccactaca cgcagaagag cctctccctg tctccgggta aa                    1842

<210> 114
<211> 614
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-7 and 11-16 of
      human IL-17RC, and Fc5

<400> 114
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Glu
        195                 200                 205             
Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu
    210                 215                 220                 
Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala
225                 230                 235                 240 
Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro
                245                 250                 255     
Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu
            260                 265                 270         
Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn
        275                 280                 285             
Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu
    290                 295                 300                 
Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln
305                 310                 315                 320 
Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu
                325                 330                 335     
Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu
            340                 345                 350         
Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu
        355                 360                 365             
Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Lys Glu Pro
    370                 375                 380                 
Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
385                 390                 395                 400 
Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                405                 410                 415     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            420                 425                 430         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        435                 440                 445             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    450                 455                 460                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
465                 470                 475                 480 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                485                 490                 495     
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            500                 505                 510         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
        515                 520                 525             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    530                 535                 540                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
545                 550                 555                 560 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                565                 570                 575     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            580                 585                 590         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        595                 600                 605             
Ser Leu Ser Pro Gly Lys
    610                 


<210> 115
<211> 1524
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-13 of human
      IL-17RC, and exons 7-9 of human IL-17RA

<400> 115
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agggaggacc cccgcgcaca ccagaacctc 900
tggcaagccg cccgactgcg actgctgacc ctgcagagct ggctgctgga cgcaccgtgc 960
tcgctgcccg cagaagcggc actgtgctgg cgggctccgg gtggggaccc ctgccagcca 1020
ctggtcccac cgctttcctg ggagaacgtc actgtggaca aggttctcga gttcccattg 1080
ctgaaaggcc accctaacct ctgtgttcag gtgaacagct cggagaagct gcagctgcag 1140
gagtgcttgt gggctggcag cctttgggat cccaacatca ctgtggagac cttggacaca 1200
cagcatctgc gagtggactt caccctgtgg aatgaatcca ccccctacca ggtcctgctg 1260
gaaagtttct ccgactcaga gaaccacagc tgctttgatg tcgttaaaca aatatttgcg 1320
cccaggcaag aagaattcca tcagcgagct aatgtcacat tcactctaag caagtttcac 1380
tggtgctgcc atcaccacgt gcaggtccag cccttcttca gcagctgcct aaatgactgt 1440
ttgagacacg ctgtgactgt gccctgccca gtaatctcaa ataccacagt tcccaagcca 1500
gttgcagact acattcccct gtgg                                        1524

<210> 116
<211> 508
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-13 of human
      IL-17RC, and exons 7-9 of human IL-17RA

<400> 116
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
    290                 295                 300                 
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
305                 310                 315                 320 
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
                325                 330                 335     
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
            340                 345                 350         
Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys
        355                 360                 365             
Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp
    370                 375                 380                 
Ala Gly Ser Leu Trp Asp Pro Asn Ile Thr Val Glu Thr Leu Asp Thr
385                 390                 395                 400 
Gln His Leu Arg Val Asp Phe Thr Leu Trp Asn Glu Ser Thr Pro Tyr
                405                 410                 415     
Gln Val Leu Leu Glu Ser Phe Ser Asp Ser Glu Asn His Ser Cys Phe
            420                 425                 430         
Asp Val Val Lys Gln Ile Phe Ala Pro Arg Gln Glu Glu Phe His Gln
        435                 440                 445             
Arg Ala Asn Val Thr Phe Thr Leu Ser Lys Phe His Trp Cys Cys His
    450                 455                 460                 
His His Val Gln Val Gln Pro Phe Phe Ser Ser Cys Leu Asn Asp Cys
465                 470                 475                 480 
Leu Arg His Ala Val Thr Val Pro Cys Pro Val Ile Ser Asn Thr Thr
                485                 490                 495     
Val Pro Lys Pro Val Ala Asp Tyr Ile Pro Leu Trp
            500                 505             


<210> 117
<211> 2220
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-13 of human
      IL-17RC, and exons 7-9 of human IL-17RA, and Fc5

<400> 117
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agggaggacc cccgcgcaca ccagaacctc 900
tggcaagccg cccgactgcg actgctgacc ctgcagagct ggctgctgga cgcaccgtgc 960
tcgctgcccg cagaagcggc actgtgctgg cgggctccgg gtggggaccc ctgccagcca 1020
ctggtcccac cgctttcctg ggagaacgtc actgtggaca aggttctcga gttcccattg 1080
ctgaaaggcc accctaacct ctgtgttcag gtgaacagct cggagaagct gcagctgcag 1140
gagtgcttgt gggctggcag cctttgggat cccaacatca ctgtggagac cttggacaca 1200
cagcatctgc gagtggactt caccctgtgg aatgaatcca ccccctacca ggtcctgctg 1260
gaaagtttct ccgactcaga gaaccacagc tgctttgatg tcgttaaaca aatatttgcg 1320
cccaggcaag aagaattcca tcagcgagct aatgtcacat tcactctaag caagtttcac 1380
tggtgctgcc atcaccacgt gcaggtccag cccttcttca gcagctgcct aaatgactgt 1440
ttgagacacg ctgtgactgt gccctgccca gtaatctcaa ataccacagt tcccaagcca 1500
gttgcagact acattcccct gtgggagccc aaatcttcag acaaaactca cacatgccca 1560
ccgtgcccag cacctgaagc cgagggggca ccgtcagtct tcctcttccc cccaaaaccc 1620
aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 1680
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 1740
aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 1800
gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 1860
ctcccatcct ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 1920
gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc 1980
ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 2040
gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac 2100
agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg 2160
atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa 2220


<210> 118
<211> 740
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal peptide and exons 1-13 of human
      IL-17RC, and exons 7-9 of human IL-17RA, and Fc5

<400> 118
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
    290                 295                 300                 
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
305                 310                 315                 320 
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
                325                 330                 335     
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
            340                 345                 350         
Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys
        355                 360                 365             
Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp
    370                 375                 380                 
Ala Gly Ser Leu Trp Asp Pro Asn Ile Thr Val Glu Thr Leu Asp Thr
385                 390                 395                 400 
Gln His Leu Arg Val Asp Phe Thr Leu Trp Asn Glu Ser Thr Pro Tyr
                405                 410                 415     
Gln Val Leu Leu Glu Ser Phe Ser Asp Ser Glu Asn His Ser Cys Phe
            420                 425                 430         
Asp Val Val Lys Gln Ile Phe Ala Pro Arg Gln Glu Glu Phe His Gln
        435                 440                 445             
Arg Ala Asn Val Thr Phe Thr Leu Ser Lys Phe His Trp Cys Cys His
    450                 455                 460                 
His His Val Gln Val Gln Pro Phe Phe Ser Ser Cys Leu Asn Asp Cys
465                 470                 475                 480 
Leu Arg His Ala Val Thr Val Pro Cys Pro Val Ile Ser Asn Thr Thr
                485                 490                 495     
Val Pro Lys Pro Val Ala Asp Tyr Ile Pro Leu Trp Glu Pro Lys Ser
            500                 505                 510         
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu
        515                 520                 525             
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
    530                 535                 540                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
545                 550                 555                 560 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                565                 570                 575     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            580                 585                 590         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        595                 600                 605             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser
    610                 615                 620                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
625                 630                 635                 640 
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
                645                 650                 655     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            660                 665                 670         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        675                 680                 685             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
    690                 695                 700                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
705                 710                 715                 720 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                725                 730                 735     
Ser Pro Gly Lys
            740 


<210> 119
<211> 1500
<212> DNA
<213> Artificial Sequence

<220> 
<223> Murine IL-17RA signal peptide and exons 1-6 of
      murine  IL-17RA, exons 8-13 of human IL-17RC, and
      exons 7-9 of murine Il-17RA

<400> 119
atggcgattc ggcgctgctg gccacgggtc gtccccgggc ccgcgctggg atggctgctt 60
ctgctgctga acgttctggc cccgggccgc gcctccccgc gcctcctcga cttcccggct 120
ccggtctgcg cgcaggaggg gctgagctgc agagtcaaga atagtacttg tctggatgac 180
agctggatcc accccaaaaa cctgaccccg tcttccccaa aaaacatcta tatcaatctt 240
agtgtttcct ctacccagca cggagaatta gtccctgtgt tgcatgttga gtggaccctg 300
cagacagatg ccagcatcct gtacctcgag ggtgcagagc tgtccgtcct gcagctgaac 360
accaatgagc ggctgtgtgt caagttccag tttctgtcca tgctgcagca tcaccgtaag 420
cggtggcggt tttccttcag ccactttgtg gtagatcctg gccaggagta tgaagtgact 480
gttcaccacc tgccgaagcc catccctgat ggggacccaa accacaaatc caagatcatc 540
tttgtgcctg actgtgagga cagcaagatg aagatgacta cctcatgcgt gagctcagcc 600
ctgccctggc tcaacgtgtc agcagatggt gacaacgtgc atctggttct gaatgtctct 660
gaggagcagc acttcggcct ctccctgtac tggaatcagg tccagggccc cccaaaaccc 720
cggtggcaca aaaacctgac tggaccgcag atcattacct tgaaccacac agacctggtt 780
ccctgcctct gtattcaggt gtggcctctg gaacctgact ccgttaggac gaacatctgc 840
cccttcaggg aggacccccg cgcacaccag aacctctggc aagccgcccg actgcgactg 900
ctgaccctgc agagctggct gctggacgca ccgtgctcgc tgcccgcaga agcggcactg 960
tgctggcggg ctccgggtgg ggacccctgc cagccactgg tcccaccgct ttcctgggag 1020
aacgtcactg tggacaaggt tctcgagttc ccattgctga aaggccaccc taacctctgt 1080
gttcaggtga acagctcgga gaagctgcag ctgcaggagt gcttgtgggc tggcagcctt 1140
tgggatccca acatcactgt ggagaccttg gacacacagc atctgcgagt ggacttcacc 1200
ctgtggaatg aatccacccc ctaccaggtc ctgctggaaa gtttctccga ctcagagaac 1260
cacagctgct ttgatgtcgt taaacaaata tttgcgccca ggcaagaaga attccatcag 1320
cgagctaatg tcacattcac tctaagcaag tttcactggt gctgccatca ccacgtgcag 1380
gtccagccct tcttcagcag ctgcctaaat gactgtttga gacacgctgt gactgtgccc 1440
tgcccagtaa tctcaaatac cacagttccc aagccagttg cagactacat tcccctgtgg 1500


<210> 120
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> Murine IL-17RA signal peptide and exons 1-6 of
      murine  IL-17RA, exons 8-13 of human IL-17RC, and
      exons 7-9 of murine Il-17RA

<400> 120
Met Ala Ile Arg Arg Cys Trp Pro Arg Val Val Pro Gly Pro Ala Leu
 1               5                  10                  15      
Gly Trp Leu Leu Leu Leu Leu Asn Val Leu Ala Pro Gly Arg Ala Ser
            20                  25                  30          
Pro Arg Leu Leu Asp Phe Pro Ala Pro Val Cys Ala Gln Glu Gly Leu
        35                  40                  45              
Ser Cys Arg Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His
    50                  55                  60                  
Pro Lys Asn Leu Thr Pro Ser Ser Pro Lys Asn Ile Tyr Ile Asn Leu
65                  70                  75                  80  
Ser Val Ser Ser Thr Gln His Gly Glu Leu Val Pro Val Leu His Val
                85                  90                  95      
Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala
            100                 105                 110         
Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Lys
        115                 120                 125             
Phe Gln Phe Leu Ser Met Leu Gln His His Arg Lys Arg Trp Arg Phe
    130                 135                 140                 
Ser Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val Thr
145                 150                 155                 160 
Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Lys
                165                 170                 175     
Ser Lys Ile Ile Phe Val Pro Asp Cys Glu Asp Ser Lys Met Lys Met
            180                 185                 190         
Thr Thr Ser Cys Val Ser Ser Ala Leu Pro Trp Leu Asn Val Ser Ala
        195                 200                 205             
Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His
    210                 215                 220                 
Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro
225                 230                 235                 240 
Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His
                245                 250                 255     
Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro
            260                 265                 270         
Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala
        275                 280                 285             
His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln
    290                 295                 300                 
Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu
305                 310                 315                 320 
Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro
                325                 330                 335     
Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu
            340                 345                 350         
Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys
        355                 360                 365             
Leu Gln Leu Gln Glu Cys Leu Trp Ala Gly Ser Leu Trp Asp Pro Asn
    370                 375                 380                 
Ile Thr Val Glu Thr Leu Asp Thr Gln His Leu Arg Val Asp Phe Thr
385                 390                 395                 400 
Leu Trp Asn Glu Ser Thr Pro Tyr Gln Val Leu Leu Glu Ser Phe Ser
                405                 410                 415     
Asp Ser Glu Asn His Ser Cys Phe Asp Val Val Lys Gln Ile Phe Ala
            420                 425                 430         
Pro Arg Gln Glu Glu Phe His Gln Arg Ala Asn Val Thr Phe Thr Leu
        435                 440                 445             
Ser Lys Phe His Trp Cys Cys His His His Val Gln Val Gln Pro Phe
    450                 455                 460                 
Phe Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ala Val Thr Val Pro
465                 470                 475                 480 
Cys Pro Val Ile Ser Asn Thr Thr Val Pro Lys Pro Val Ala Asp Tyr
                485                 490                 495     
Ile Pro Leu Trp
            500 


<210> 121
<211> 2196
<212> DNA
<213> Artificial Sequence

<220> 
<223> Murine IL-17RA signal peptide and exons 1-6 of
      murine  IL-17RA, exons 8-13 of human IL-17RC, and
      exons 7-9 of murine Il-17RA and Fc5

<400> 121
atggcgattc ggcgctgctg gccacgggtc gtccccgggc ccgcgctggg atggctgctt 60
ctgctgctga acgttctggc cccgggccgc gcctccccgc gcctcctcga cttcccggct 120
ccggtctgcg cgcaggaggg gctgagctgc agagtcaaga atagtacttg tctggatgac 180
agctggatcc accccaaaaa cctgaccccg tcttccccaa aaaacatcta tatcaatctt 240
agtgtttcct ctacccagca cggagaatta gtccctgtgt tgcatgttga gtggaccctg 300
cagacagatg ccagcatcct gtacctcgag ggtgcagagc tgtccgtcct gcagctgaac 360
accaatgagc ggctgtgtgt caagttccag tttctgtcca tgctgcagca tcaccgtaag 420
cggtggcggt tttccttcag ccactttgtg gtagatcctg gccaggagta tgaagtgact 480
gttcaccacc tgccgaagcc catccctgat ggggacccaa accacaaatc caagatcatc 540
tttgtgcctg actgtgagga cagcaagatg aagatgacta cctcatgcgt gagctcagcc 600
ctgccctggc tcaacgtgtc agcagatggt gacaacgtgc atctggttct gaatgtctct 660
gaggagcagc acttcggcct ctccctgtac tggaatcagg tccagggccc cccaaaaccc 720
cggtggcaca aaaacctgac tggaccgcag atcattacct tgaaccacac agacctggtt 780
ccctgcctct gtattcaggt gtggcctctg gaacctgact ccgttaggac gaacatctgc 840
cccttcaggg aggacccccg cgcacaccag aacctctggc aagccgcccg actgcgactg 900
ctgaccctgc agagctggct gctggacgca ccgtgctcgc tgcccgcaga agcggcactg 960
tgctggcggg ctccgggtgg ggacccctgc cagccactgg tcccaccgct ttcctgggag 1020
aacgtcactg tggacaaggt tctcgagttc ccattgctga aaggccaccc taacctctgt 1080
gttcaggtga acagctcgga gaagctgcag ctgcaggagt gcttgtgggc tggcagcctt 1140
tgggatccca acatcactgt ggagaccttg gacacacagc atctgcgagt ggacttcacc 1200
ctgtggaatg aatccacccc ctaccaggtc ctgctggaaa gtttctccga ctcagagaac 1260
cacagctgct ttgatgtcgt taaacaaata tttgcgccca ggcaagaaga attccatcag 1320
cgagctaatg tcacattcac tctaagcaag tttcactggt gctgccatca ccacgtgcag 1380
gtccagccct tcttcagcag ctgcctaaat gactgtttga gacacgctgt gactgtgccc 1440
tgcccagtaa tctcaaatac cacagttccc aagccagttg cagactacat tcccctgtgg 1500
gagcccaaat cttcagacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgag 1560
ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 1620
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 1680
aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 1740
tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 1800
ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc catcctccat cgagaaaacc 1860
atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1920
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 1980
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 2040
cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc 2100
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 2160
tacacgcaga agagcctctc cctgtctccg ggtaaa                           2196

<210> 122
<211> 2196
<212> PRT
<213> Artificial Sequence

<220> 
<223> Murine IL-17RA signal peptide and exons 1-6 of
      murine  IL-17RA, exons 8-13 of human IL-17RC, and
      exons 7-9 of murine Il-17RA and Fc5

<400> 122
Ala Thr Gly Gly Cys Gly Ala Thr Thr Cys Gly Gly Cys Gly Cys Thr
 1               5                  10                  15      
Gly Cys Thr Gly Gly Cys Cys Ala Cys Gly Gly Gly Thr Cys Gly Thr
            20                  25                  30          
Cys Cys Cys Cys Gly Gly Gly Cys Cys Cys Gly Cys Gly Cys Thr Gly
        35                  40                  45              
Gly Gly Ala Thr Gly Gly Cys Thr Gly Cys Thr Thr Cys Thr Gly Cys
    50                  55                  60                  
Thr Gly Cys Thr Gly Ala Ala Cys Gly Thr Thr Cys Thr Gly Gly Cys
65                  70                  75                  80  
Cys Cys Cys Gly Gly Gly Cys Cys Gly Cys Gly Cys Cys Thr Cys Cys
                85                  90                  95      
Cys Cys Gly Cys Gly Cys Cys Thr Cys Cys Thr Cys Gly Ala Cys Thr
            100                 105                 110         
Thr Cys Cys Cys Gly Gly Cys Thr Cys Cys Gly Gly Thr Cys Thr Gly
        115                 120                 125             
Cys Gly Cys Gly Cys Ala Gly Gly Ala Gly Gly Gly Gly Cys Thr Gly
    130                 135                 140                 
Ala Gly Cys Thr Gly Cys Ala Gly Ala Gly Thr Cys Ala Ala Gly Ala
145                 150                 155                 160 
Ala Thr Ala Gly Thr Ala Cys Thr Thr Gly Thr Cys Thr Gly Gly Ala
                165                 170                 175     
Thr Gly Ala Cys Ala Gly Cys Thr Gly Gly Ala Thr Cys Cys Ala Cys
            180                 185                 190         
Cys Cys Cys Ala Ala Ala Ala Ala Cys Cys Thr Gly Ala Cys Cys Cys
        195                 200                 205             
Cys Gly Thr Cys Thr Thr Cys Cys Cys Cys Ala Ala Ala Ala Ala Ala
    210                 215                 220                 
Cys Ala Thr Cys Thr Ala Thr Ala Thr Cys Ala Ala Thr Cys Thr Thr
225                 230                 235                 240 
Ala Gly Thr Gly Thr Thr Thr Cys Cys Thr Cys Thr Ala Cys Cys Cys
                245                 250                 255     
Ala Gly Cys Ala Cys Gly Gly Ala Gly Ala Ala Thr Thr Ala Gly Thr
            260                 265                 270         
Cys Cys Cys Thr Gly Thr Gly Thr Thr Gly Cys Ala Thr Gly Thr Thr
        275                 280                 285             
Gly Ala Gly Thr Gly Gly Ala Cys Cys Cys Thr Gly Cys Ala Gly Ala
    290                 295                 300                 
Cys Ala Gly Ala Thr Gly Cys Cys Ala Gly Cys Ala Thr Cys Cys Thr
305                 310                 315                 320 
Gly Thr Ala Cys Cys Thr Cys Gly Ala Gly Gly Gly Thr Gly Cys Ala
                325                 330                 335     
Gly Ala Gly Cys Thr Gly Thr Cys Cys Gly Thr Cys Cys Thr Gly Cys
            340                 345                 350         
Ala Gly Cys Thr Gly Ala Ala Cys Ala Cys Cys Ala Ala Thr Gly Ala
        355                 360                 365             
Gly Cys Gly Gly Cys Thr Gly Thr Gly Thr Gly Thr Cys Ala Ala Gly
    370                 375                 380                 
Thr Thr Cys Cys Ala Gly Thr Thr Thr Cys Thr Gly Thr Cys Cys Ala
385                 390                 395                 400 
Thr Gly Cys Thr Gly Cys Ala Gly Cys Ala Thr Cys Ala Cys Cys Gly
                405                 410                 415     
Thr Ala Ala Gly Cys Gly Gly Thr Gly Gly Cys Gly Gly Thr Thr Thr
            420                 425                 430         
Thr Cys Cys Thr Thr Cys Ala Gly Cys Cys Ala Cys Thr Thr Thr Gly
        435                 440                 445             
Thr Gly Gly Thr Ala Gly Ala Thr Cys Cys Thr Gly Gly Cys Cys Ala
    450                 455                 460                 
Gly Gly Ala Gly Thr Ala Thr Gly Ala Ala Gly Thr Gly Ala Cys Thr
465                 470                 475                 480 
Gly Thr Thr Cys Ala Cys Cys Ala Cys Cys Thr Gly Cys Cys Gly Ala
                485                 490                 495     
Ala Gly Cys Cys Cys Ala Thr Cys Cys Cys Thr Gly Ala Thr Gly Gly
            500                 505                 510         
Gly Gly Ala Cys Cys Cys Ala Ala Ala Cys Cys Ala Cys Ala Ala Ala
        515                 520                 525             
Thr Cys Cys Ala Ala Gly Ala Thr Cys Ala Thr Cys Thr Thr Thr Gly
    530                 535                 540                 
Thr Gly Cys Cys Thr Gly Ala Cys Thr Gly Thr Gly Ala Gly Gly Ala
545                 550                 555                 560 
Cys Ala Gly Cys Ala Ala Gly Ala Thr Gly Ala Ala Gly Ala Thr Gly
                565                 570                 575     
Ala Cys Thr Ala Cys Cys Thr Cys Ala Thr Gly Cys Gly Thr Gly Ala
            580                 585                 590         
Gly Cys Thr Cys Ala Gly Cys Cys Cys Thr Gly Cys Cys Cys Thr Gly
        595                 600                 605             
Gly Cys Thr Cys Ala Ala Cys Gly Thr Gly Thr Cys Ala Gly Cys Ala
    610                 615                 620                 
Gly Ala Thr Gly Gly Thr Gly Ala Cys Ala Ala Cys Gly Thr Gly Cys
625                 630                 635                 640 
Ala Thr Cys Thr Gly Gly Thr Thr Cys Thr Gly Ala Ala Thr Gly Thr
                645                 650                 655     
Cys Thr Cys Thr Gly Ala Gly Gly Ala Gly Cys Ala Gly Cys Ala Cys
            660                 665                 670         
Thr Thr Cys Gly Gly Cys Cys Thr Cys Thr Cys Cys Cys Thr Gly Thr
        675                 680                 685             
Ala Cys Thr Gly Gly Ala Ala Thr Cys Ala Gly Gly Thr Cys Cys Ala
    690                 695                 700                 
Gly Gly Gly Cys Cys Cys Cys Cys Cys Ala Ala Ala Ala Cys Cys Cys
705                 710                 715                 720 
Cys Gly Gly Thr Gly Gly Cys Ala Cys Ala Ala Ala Ala Ala Cys Cys
                725                 730                 735     
Thr Gly Ala Cys Thr Gly Gly Ala Cys Cys Gly Cys Ala Gly Ala Thr
            740                 745                 750         
Cys Ala Thr Thr Ala Cys Cys Thr Thr Gly Ala Ala Cys Cys Ala Cys
        755                 760                 765             
Ala Cys Ala Gly Ala Cys Cys Thr Gly Gly Thr Thr Cys Cys Cys Thr
    770                 775                 780                 
Gly Cys Cys Thr Cys Thr Gly Thr Ala Thr Thr Cys Ala Gly Gly Thr
785                 790                 795                 800 
Gly Thr Gly Gly Cys Cys Thr Cys Thr Gly Gly Ala Ala Cys Cys Thr
                805                 810                 815     
Gly Ala Cys Thr Cys Cys Gly Thr Thr Ala Gly Gly Ala Cys Gly Ala
            820                 825                 830         
Ala Cys Ala Thr Cys Thr Gly Cys Cys Cys Cys Thr Thr Cys Ala Gly
        835                 840                 845             
Gly Gly Ala Gly Gly Ala Cys Cys Cys Cys Cys Gly Cys Gly Cys Ala
    850                 855                 860                 
Cys Ala Cys Cys Ala Gly Ala Ala Cys Cys Thr Cys Thr Gly Gly Cys
865                 870                 875                 880 
Ala Ala Gly Cys Cys Gly Cys Cys Cys Gly Ala Cys Thr Gly Cys Gly
                885                 890                 895     
Ala Cys Thr Gly Cys Thr Gly Ala Cys Cys Cys Thr Gly Cys Ala Gly
            900                 905                 910         
Ala Gly Cys Thr Gly Gly Cys Thr Gly Cys Thr Gly Gly Ala Cys Gly
        915                 920                 925             
Cys Ala Cys Cys Gly Thr Gly Cys Thr Cys Gly Cys Thr Gly Cys Cys
    930                 935                 940                 
Cys Gly Cys Ala Gly Ala Ala Gly Cys Gly Gly Cys Ala Cys Thr Gly
945                 950                 955                 960 
Thr Gly Cys Thr Gly Gly Cys Gly Gly Gly Cys Thr Cys Cys Gly Gly
                965                 970                 975     
Gly Thr Gly Gly Gly Gly Ala Cys Cys Cys Cys Thr Gly Cys Cys Ala
            980                 985                 990         
Gly Cys Cys Ala Cys Thr Gly Gly Thr Cys Cys Cys Ala Cys Cys Gly
        995                 1000                1005            
Cys Thr Thr Thr Cys Cys Thr Gly Gly Gly Ala Gly Ala Ala Cys Gly
    1010                1015                1020                
Thr Cys Ala Cys Thr Gly Thr Gly Gly Ala Cys Ala Ala Gly Gly Thr
1025                1030                1035                1040
Thr Cys Thr Cys Gly Ala Gly Thr Thr Cys Cys Cys Ala Thr Thr Gly
                1045                1050                1055    
Cys Thr Gly Ala Ala Ala Gly Gly Cys Cys Ala Cys Cys Cys Thr Ala
            1060                1065                1070        
Ala Cys Cys Thr Cys Thr Gly Thr Gly Thr Thr Cys Ala Gly Gly Thr
        1075                1080                1085            
Gly Ala Ala Cys Ala Gly Cys Thr Cys Gly Gly Ala Gly Ala Ala Gly
    1090                1095                1100                
Cys Thr Gly Cys Ala Gly Cys Thr Gly Cys Ala Gly Gly Ala Gly Thr
1105                1110                1115                1120
Gly Cys Thr Thr Gly Thr Gly Gly Gly Cys Thr Gly Gly Cys Ala Gly
                1125                1130                1135    
Cys Cys Thr Thr Thr Gly Gly Gly Ala Thr Cys Cys Cys Ala Ala Cys
            1140                1145                1150        
Ala Thr Cys Ala Cys Thr Gly Thr Gly Gly Ala Gly Ala Cys Cys Thr
        1155                1160                1165            
Thr Gly Gly Ala Cys Ala Cys Ala Cys Ala Gly Cys Ala Thr Cys Thr
    1170                1175                1180                
Gly Cys Gly Ala Gly Thr Gly Gly Ala Cys Thr Thr Cys Ala Cys Cys
1185                1190                1195                1200
Cys Thr Gly Thr Gly Gly Ala Ala Thr Gly Ala Ala Thr Cys Cys Ala
                1205                1210                1215    
Cys Cys Cys Cys Cys Thr Ala Cys Cys Ala Gly Gly Thr Cys Cys Thr
            1220                1225                1230        
Gly Cys Thr Gly Gly Ala Ala Ala Gly Thr Thr Thr Cys Thr Cys Cys
        1235                1240                1245            
Gly Ala Cys Thr Cys Ala Gly Ala Gly Ala Ala Cys Cys Ala Cys Ala
    1250                1255                1260                
Gly Cys Thr Gly Cys Thr Thr Thr Gly Ala Thr Gly Thr Cys Gly Thr
1265                1270                1275                1280
Thr Ala Ala Ala Cys Ala Ala Ala Thr Ala Thr Thr Thr Gly Cys Gly
                1285                1290                1295    
Cys Cys Cys Ala Gly Gly Cys Ala Ala Gly Ala Ala Gly Ala Ala Thr
            1300                1305                1310        
Thr Cys Cys Ala Thr Cys Ala Gly Cys Gly Ala Gly Cys Thr Ala Ala
        1315                1320                1325            
Thr Gly Thr Cys Ala Cys Ala Thr Thr Cys Ala Cys Thr Cys Thr Ala
    1330                1335                1340                
Ala Gly Cys Ala Ala Gly Thr Thr Thr Cys Ala Cys Thr Gly Gly Thr
1345                1350                1355                1360
Gly Cys Thr Gly Cys Cys Ala Thr Cys Ala Cys Cys Ala Cys Gly Thr
                1365                1370                1375    
Gly Cys Ala Gly Gly Thr Cys Cys Ala Gly Cys Cys Cys Thr Thr Cys
            1380                1385                1390        
Thr Thr Cys Ala Gly Cys Ala Gly Cys Thr Gly Cys Cys Thr Ala Ala
        1395                1400                1405            
Ala Thr Gly Ala Cys Thr Gly Thr Thr Thr Gly Ala Gly Ala Cys Ala
    1410                1415                1420                
Cys Gly Cys Thr Gly Thr Gly Ala Cys Thr Gly Thr Gly Cys Cys Cys
1425                1430                1435                1440
Thr Gly Cys Cys Cys Ala Gly Thr Ala Ala Thr Cys Thr Cys Ala Ala
                1445                1450                1455    
Ala Thr Ala Cys Cys Ala Cys Ala Gly Thr Thr Cys Cys Cys Ala Ala
            1460                1465                1470        
Gly Cys Cys Ala Gly Thr Thr Gly Cys Ala Gly Ala Cys Thr Ala Cys
        1475                1480                1485            
Ala Thr Thr Cys Cys Cys Cys Thr Gly Thr Gly Gly Gly Ala Gly Cys
    1490                1495                1500                
Cys Cys Ala Ala Ala Thr Cys Thr Thr Cys Ala Gly Ala Cys Ala Ala
1505                1510                1515                1520
Ala Ala Cys Thr Cys Ala Cys Ala Cys Ala Thr Gly Cys Cys Cys Ala
                1525                1530                1535    
Cys Cys Gly Thr Gly Cys Cys Cys Ala Gly Cys Ala Cys Cys Thr Gly
            1540                1545                1550        
Ala Ala Gly Cys Cys Gly Ala Gly Gly Gly Gly Gly Cys Ala Cys Cys
        1555                1560                1565            
Gly Thr Cys Ala Gly Thr Cys Thr Thr Cys Cys Thr Cys Thr Thr Cys
    1570                1575                1580                
Cys Cys Cys Cys Cys Ala Ala Ala Ala Cys Cys Cys Ala Ala Gly Gly
1585                1590                1595                1600
Ala Cys Ala Cys Cys Cys Thr Cys Ala Thr Gly Ala Thr Cys Thr Cys
                1605                1610                1615    
Cys Cys Gly Gly Ala Cys Cys Cys Cys Thr Gly Ala Gly Gly Thr Cys
            1620                1625                1630        
Ala Cys Ala Thr Gly Cys Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly
        1635                1640                1645            
Ala Cys Gly Thr Gly Ala Gly Cys Cys Ala Cys Gly Ala Ala Gly Ala
    1650                1655                1660                
Cys Cys Cys Thr Gly Ala Gly Gly Thr Cys Ala Ala Gly Thr Thr Cys
1665                1670                1675                1680
Ala Ala Cys Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly
                1685                1690                1695    
Gly Cys Gly Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala Thr Ala Ala
            1700                1705                1710        
Thr Gly Cys Cys Ala Ala Gly Ala Cys Ala Ala Ala Gly Cys Cys Gly
        1715                1720                1725            
Cys Gly Gly Gly Ala Gly Gly Ala Gly Cys Ala Gly Thr Ala Cys Ala
    1730                1735                1740                
Ala Cys Ala Gly Cys Ala Cys Gly Thr Ala Cys Cys Gly Thr Gly Thr
1745                1750                1755                1760
Gly Gly Thr Cys Ala Gly Cys Gly Thr Cys Cys Thr Cys Ala Cys Cys
                1765                1770                1775    
Gly Thr Cys Cys Thr Gly Cys Ala Cys Cys Ala Gly Gly Ala Cys Thr
            1780                1785                1790        
Gly Gly Cys Thr Gly Ala Ala Thr Gly Gly Cys Ala Ala Gly Gly Ala
        1795                1800                1805            
Gly Thr Ala Cys Ala Ala Gly Thr Gly Cys Ala Ala Gly Gly Thr Cys
    1810                1815                1820                
Thr Cys Cys Ala Ala Cys Ala Ala Ala Gly Cys Cys Cys Thr Cys Cys
1825                1830                1835                1840
Cys Ala Thr Cys Cys Thr Cys Cys Ala Thr Cys Gly Ala Gly Ala Ala
                1845                1850                1855    
Ala Ala Cys Cys Ala Thr Cys Thr Cys Cys Ala Ala Ala Gly Cys Cys
            1860                1865                1870        
Ala Ala Ala Gly Gly Gly Cys Ala Gly Cys Cys Cys Cys Gly Ala Gly
        1875                1880                1885            
Ala Ala Cys Cys Ala Cys Ala Gly Gly Thr Gly Thr Ala Cys Ala Cys
    1890                1895                1900                
Cys Cys Thr Gly Cys Cys Cys Cys Cys Ala Thr Cys Cys Cys Gly Gly
1905                1910                1915                1920
Gly Ala Thr Gly Ala Gly Cys Thr Gly Ala Cys Cys Ala Ala Gly Ala
                1925                1930                1935    
Ala Cys Cys Ala Gly Gly Thr Cys Ala Gly Cys Cys Thr Gly Ala Cys
            1940                1945                1950        
Cys Thr Gly Cys Cys Thr Gly Gly Thr Cys Ala Ala Ala Gly Gly Cys
        1955                1960                1965            
Thr Thr Cys Thr Ala Thr Cys Cys Cys Ala Gly Cys Gly Ala Cys Ala
    1970                1975                1980                
Thr Cys Gly Cys Cys Gly Thr Gly Gly Ala Gly Thr Gly Gly Gly Ala
1985                1990                1995                2000
Gly Ala Gly Cys Ala Ala Thr Gly Gly Gly Cys Ala Gly Cys Cys Gly
                2005                2010                2015    
Gly Ala Gly Ala Ala Cys Ala Ala Cys Thr Ala Cys Ala Ala Gly Ala
            2020                2025                2030        
Cys Cys Ala Cys Gly Cys Cys Thr Cys Cys Cys Gly Thr Gly Cys Thr
        2035                2040                2045            
Gly Gly Ala Cys Thr Cys Cys Gly Ala Cys Gly Gly Cys Thr Cys Cys
    2050                2055                2060                
Thr Thr Cys Thr Thr Cys Cys Thr Cys Thr Ala Cys Ala Gly Cys Ala
2065                2070                2075                2080
Ala Gly Cys Thr Cys Ala Cys Cys Gly Thr Gly Gly Ala Cys Ala Ala
                2085                2090                2095    
Gly Ala Gly Cys Ala Gly Gly Thr Gly Gly Cys Ala Gly Cys Ala Gly
            2100                2105                2110        
Gly Gly Gly Ala Ala Cys Gly Thr Cys Thr Thr Cys Thr Cys Ala Thr
        2115                2120                2125            
Gly Cys Thr Cys Cys Gly Thr Gly Ala Thr Gly Cys Ala Thr Gly Ala
    2130                2135                2140                
Gly Gly Cys Thr Cys Thr Gly Cys Ala Cys Ala Ala Cys Cys Ala Cys
2145                2150                2155                2160
Thr Ala Cys Ala Cys Gly Cys Ala Gly Ala Ala Gly Ala Gly Cys Cys
                2165                2170                2175    
Thr Cys Thr Cys Cys Cys Thr Gly Thr Cys Thr Cys Cys Gly Gly Gly
            2180                2185                2190        
Thr Ala Ala Ala
        2195    


<210> 123
<211> 1272
<212> DNA
<213> Artificial Sequence

<220> 
<223>  IL-17RC signal peptide and exons 1-6 of human
      IL-17RC, and Fc5

<400> 123
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgagc ccaaatcttc agacaaaact 600
cacacatgcc caccgtgccc agcacctgaa gccgaggggg caccgtcagt cttcctcttc 660
cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 720
gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 780
gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 840
agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc 900
tccaacaaag ccctcccatc ctccatcgag aaaaccatct ccaaagccaa agggcagccc 960
cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc 1020
agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 1080
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1140
ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 1200
tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 1260
tctccgggta aa                                                     1272

<210> 124
<211> 424
<212> PRT
<213> Artificial Sequence

<220> 
<223>  IL-17RC signal peptide and exons 1-6 of human
      IL-17RC, and Fc5

<400> 124
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
        195                 200                 205             
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
    210                 215                 220                 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
225                 230                 235                 240 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
                245                 250                 255     
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
            260                 265                 270         
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
        275                 280                 285             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
    290                 295                 300                 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
305                 310                 315                 320 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
                325                 330                 335     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
            340                 345                 350         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
        355                 360                 365             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
    370                 375                 380                 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
385                 390                 395                 400 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                405                 410                 415     
Ser Leu Ser Leu Ser Pro Gly Lys
            420                 


<210> 125
<211> 1794
<212> DNA
<213> Artificial Sequence

<220> 
<223>  IL-17RC signal peptide and exons 1-6 and 11-16 of
      human IL-17RC, and Fc5

<400> 125
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgacc cccgcgcaca ccagaacctc 600
tggcaagccg cccgactgcg actgctgacc ctgcagagct ggctgctgga cgcaccgtgc 660
tcgctgcccg cagaagcggc actgtgctgg cgggctccgg gtggggaccc ctgccagcca 720
ctggtcccac cgctttcctg ggagaacgtc actgtggaca aggttctcga gttcccattg 780
ctgaaaggcc accctaacct ctgtgttcag gtgaacagct cggagaagct gcagctgcag 840
gagtgcttgt gggctgactc cctggggcct ctcaaagacg atgtgctact gttggagaca 900
cgaggccccc aggacaacag atccctctgt gccttggaac ccagtggctg tacttcacta 960
cccagcaaag cctccacgag ggcagctcgc cttggagagt acttactaca agacctgcag 1020
tcaggccagt gtctgcagct atgggacgat gacttgggag cgctatgggc ctgccccatg 1080
gacaaataca tccacaagga gcccaaatct tcagacaaaa ctcacacatg cccaccgtgc 1140
ccagcacctg aagccgaggg ggcaccgtca gtcttcctct tccccccaaa acccaaggac 1200
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 1260
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 1320
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 1380
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 1440
tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 1500
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 1560
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 1620
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 1680
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 1740
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       1794

<210> 126
<211> 598
<212> PRT
<213> Artificial Sequence

<220> 
<223>  IL-17RC signal peptide and exons 1-6 and 11-16 of
      human IL-17RC, and Fc5

<400> 126
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu
        195                 200                 205             
Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala
    210                 215                 220                 
Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro
225                 230                 235                 240 
Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu
                245                 250                 255     
Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn
            260                 265                 270         
Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu
        275                 280                 285             
Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln
    290                 295                 300                 
Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu
305                 310                 315                 320 
Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu
                325                 330                 335     
Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu
            340                 345                 350         
Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Lys Glu Pro
        355                 360                 365             
Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
    370                 375                 380                 
Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
385                 390                 395                 400 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                405                 410                 415     
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            420                 425                 430         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        435                 440                 445             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    450                 455                 460                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
465                 470                 475                 480 
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                485                 490                 495     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            500                 505                 510         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        515                 520                 525             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    530                 535                 540                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
545                 550                 555                 560 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                565                 570                 575     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            580                 585                 590         
Ser Leu Ser Pro Gly Lys
        595             


<210> 127
<211> 1515
<212> DNA
<213> Artificial Sequence

<220> 
<223>  IL-17RC signal peptide and exons 1-6 and 14-16 of
      human IL-17RC, and Fc5

<400> 127
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact ccctggggcc tctcaaagac 600
gatgtgctac tgttggagac acgaggcccc caggacaaca gatccctctg tgccttggaa 660
cccagtggct gtacttcact acccagcaaa gcctccacga gggcagctcg ccttggagag 720
tacttactac aagacctgca gtcaggccag tgtctgcagc tatgggacga tgacttggga 780
gcgctatggg cctgccccat ggacaaatac atccacaagg agcccaaatc ttcagacaaa 840
actcacacat gcccaccgtg cccagcacct gaagccgagg gggcaccgtc agtcttcctc 900
ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 960
gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg 1020
gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg 1080
gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag 1140
gtctccaaca aagccctccc atcctccatc gagaaaacca tctccaaagc caaagggcag 1200
ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 1260
gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag 1320
agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 1380
tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 1440
ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc 1500
ctgtctccgg gtaaa                                                  1515

<210> 128
<211> 505
<212> PRT
<213> Artificial Sequence

<220> 
<223>  IL-17RC signal peptide and exons 1-6 and 14-16 of
      human IL-17RC, and Fc5

<400> 128
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg
        195                 200                 205             
Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys
    210                 215                 220                 
Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu
225                 230                 235                 240 
Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp
                245                 250                 255     
Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His
            260                 265                 270         
Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
        275                 280                 285             
Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys
    290                 295                 300                 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
305                 310                 315                 320 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
                325                 330                 335     
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
            340                 345                 350         
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
        355                 360                 365             
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
    370                 375                 380                 
Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
385                 390                 395                 400 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
                405                 410                 415     
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
            420                 425                 430         
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
        435                 440                 445             
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
    450                 455                 460                 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
465                 470                 475                 480 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                485                 490                 495     
Lys Ser Leu Ser Leu Ser Pro Gly Lys
            500                 505 


<210> 129
<211> 1335
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized tissue Plasminogen Activator (otPA)
      pre-pro signal sequence and exons 8-13 of human
      IL-17RC, and Fc5
      

<400> 129
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt 60
tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagagccct gccctggctc 120
aacgtgtcag cagatggtga caacgtgcat ctggttctga atgtctctga ggagcagcac 180
ttcggcctct ccctgtactg gaatcaggtc cagggccccc caaaaccccg gtggcacaaa 240
aacctgactg gaccgcagat cattaccttg aaccacacag acctggttcc ctgcctctgt 300
attcaggtgt ggcctctgga acctgactcc gttaggacga acatctgccc cttcagggag 360
gacccccgcg cacaccagaa cctctggcaa gccgcccgac tgcgactgct gaccctgcag 420
agctggctgc tggacgcacc gtgctcgctg cccgcagaag cggcactgtg ctggcgggct 480
ccgggtgggg acccctgcca gccactggtc ccaccgcttt cctgggagaa cgtcactgtg 540
gacaaggttc tcgagttccc attgctgaaa ggccacccta acctctgtgt tcaggtgaac 600
agctcggaga agctgcagct gcaggagtgc ttgtgggctg agcccaaatc ttcagacaaa 660
actcacacat gcccaccgtg cccagcacct gaagccgagg gggcaccgtc agtcttcctc 720
ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 780
gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg 840
gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg 900
gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag 960
gtctccaaca aagccctccc atcctccatc gagaaaacca tctccaaagc caaagggcag 1020
ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 1080
gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag 1140
agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 1200
tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 1260
ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc 1320
ctgtctccgg gtaaa                                                  1335

<210> 130
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> Optimized tissue Plasminogen Activator (otPA)
      pre-pro signal sequence and exons 8-13 of human
      IL-17RC, and Fc5
      

<400> 130
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn
        35                  40                  45              
Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser
    50                  55                  60                  
Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys
65                  70                  75                  80  
Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val
                85                  90                  95      
Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg
            100                 105                 110         
Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu
        115                 120                 125             
Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu
    130                 135                 140                 
Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala
145                 150                 155                 160 
Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu
                165                 170                 175     
Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His
            180                 185                 190         
Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln
        195                 200                 205             
Glu Cys Leu Trp Ala Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        275                 280                 285             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305                 310                 315                 320 
Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 


<210> 131
<211> 1299
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized tissue Plasminogen Activator (otPA)
      pre-pro signal sequence and exons 8-10 and 14-16
      of human IL-17RC, and Fc5
      

<400> 131
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt 60
tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagagccct gccctggctc 120
aacgtgtcag cagatggtga caacgtgcat ctggttctga atgtctctga ggagcagcac 180
ttcggcctct ccctgtactg gaatcaggtc cagggccccc caaaaccccg gtggcacaaa 240
aacctgactg gaccgcagat cattaccttg aaccacacag acctggttcc ctgcctctgt 300
attcaggtgt ggcctctgga acctgactcc gttaggacga acatctgccc cttcagggag 360
gactccctgg ggcctctcaa agacgatgtg ctactgttgg agacacgagg cccccaggac 420
aacagatccc tctgtgcctt ggaacccagt ggctgtactt cactacccag caaagcctcc 480
acgagggcag ctcgccttgg agagtactta ctacaagacc tgcagtcagg ccagtgtctg 540
cagctatggg acgatgactt gggagcgcta tgggcctgcc ccatggacaa atacatccac 600
aaggagccca aatcttcaga caaaactcac acatgcccac cgtgcccagc acctgaagcc 660
gagggggcac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc 720
cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag 780
ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag 840
cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg 900
aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccatcctc catcgagaaa 960
accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 1020
cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc 1080
agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg 1140
cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag 1200
agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac 1260
cactacacgc agaagagcct ctccctgtct ccgggtaaa                        1299

<210> 132
<211> 433
<212> PRT
<213> Artificial Sequence

<220> 
<223> Optimized tissue Plasminogen Activator (otPA)
      pre-pro signal sequence and exons 8-10 and 14-16
      of human IL-17RC, and Fc5
      

<400> 132
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn
        35                  40                  45              
Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser
    50                  55                  60                  
Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys
65                  70                  75                  80  
Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val
                85                  90                  95      
Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg
            100                 105                 110         
Thr Asn Ile Cys Pro Phe Arg Glu Asp Ser Leu Gly Pro Leu Lys Asp
        115                 120                 125             
Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu
    130                 135                 140                 
Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser
145                 150                 155                 160 
Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser
                165                 170                 175     
Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala
            180                 185                 190         
Cys Pro Met Asp Lys Tyr Ile His Lys Glu Pro Lys Ser Ser Asp Lys
        195                 200                 205             
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro
    210                 215                 220                 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
225                 230                 235                 240 
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                245                 250                 255     
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
            260                 265                 270         
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
        275                 280                 285             
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
    290                 295                 300                 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys
305                 310                 315                 320 
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
                325                 330                 335     
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
            340                 345                 350         
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
        355                 360                 365             
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
    370                 375                 380                 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
385                 390                 395                 400 
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                405                 410                 415     
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
            420                 425                 430         
Lys
    


<210> 133
<211> 1056
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized tissue Plasminogen Activator (otPA)
      pre-pro signal sequence and exons 8-10 of human
      IL-17RC, and Fc5
      

<400> 133
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt 60
tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagagccct gccctggctc 120
aacgtgtcag cagatggtga caacgtgcat ctggttctga atgtctctga ggagcagcac 180
ttcggcctct ccctgtactg gaatcaggtc cagggccccc caaaaccccg gtggcacaaa 240
aacctgactg gaccgcagat cattaccttg aaccacacag acctggttcc ctgcctctgt 300
attcaggtgt ggcctctgga acctgactcc gttaggacga acatctgccc cttcagggag 360
gagcccaaat cttcagacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgag 420
ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 480
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 540
aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 600
tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 660
ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc catcctccat cgagaaaacc 720
atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 780
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 840
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 900
cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc 960
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 1020
tacacgcaga agagcctctc cctgtctccg ggtaaa                           1056

<210> 134
<211> 352
<212> PRT
<213> Artificial Sequence

<220> 
<223> Optimized tissue Plasminogen Activator (otPA)
      pre-pro signal sequence and exons 8-10 of human
      IL-17RC, and Fc5
      

<400> 134
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn
        35                  40                  45              
Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser
    50                  55                  60                  
Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys
65                  70                  75                  80  
Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val
                85                  90                  95      
Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg
            100                 105                 110         
Thr Asn Ile Cys Pro Phe Arg Glu Glu Pro Lys Ser Ser Asp Lys Thr
        115                 120                 125             
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser
    130                 135                 140                 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
145                 150                 155                 160 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
                165                 170                 175     
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
            180                 185                 190         
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
        195                 200                 205             
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
    210                 215                 220                 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr
225                 230                 235                 240 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
                245                 250                 255     
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
            260                 265                 270         
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
        275                 280                 285             
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
    290                 295                 300                 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
305                 310                 315                 320 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
                325                 330                 335     
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            340                 345                 350         


<210> 135
<211> 1080
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized tissue Plasminogen Activator (otPA)
      pre-pro signal sequence and exons 11-13 of human
      IL-17RC, and Fc5
      

<400> 135
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt 60
tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagagaccc ccgcgcacac 120
cagaacctct ggcaagccgc ccgactgcga ctgctgaccc tgcagagctg gctgctggac 180
gcaccgtgct cgctgcccgc agaagcggca ctgtgctggc gggctccggg tggggacccc 240
tgccagccac tggtcccacc gctttcctgg gagaacgtca ctgtggacaa ggttctcgag 300
ttcccattgc tgaaaggcca ccctaacctc tgtgttcagg tgaacagctc ggagaagctg 360
cagctgcagg agtgcttgtg ggctgagccc aaatcttcag acaaaactca cacatgccca 420
ccgtgcccag cacctgaagc cgagggggca ccgtcagtct tcctcttccc cccaaaaccc 480
aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 540
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 600
aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 660
gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 720
ctcccatcct ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 780
gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc 840
ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 900
gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac 960
agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg 1020
atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa 1080


<210> 136
<211> 360
<212> PRT
<213> Artificial Sequence

<220> 
<223> Optimized tissue Plasminogen Activator (otPA)
      pre-pro signal sequence and exons 11-13 of human
      IL-17RC, and Fc5
      

<400> 136
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala Arg
        35                  40                  45              
Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys Ser
    50                  55                  60                  
Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp Pro
65                  70                  75                  80  
Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val Asp
                85                  90                  95      
Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys Val
            100                 105                 110         
Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala
        115                 120                 125             
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
    130                 135                 140                 
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
145                 150                 155                 160 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                165                 170                 175     
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
            180                 185                 190         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
        195                 200                 205             
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
    210                 215                 220                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
225                 230                 235                 240 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
                245                 250                 255     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
            260                 265                 270         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
        275                 280                 285             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
    290                 295                 300                 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
305                 310                 315                 320 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
                325                 330                 335     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
            340                 345                 350         
Ser Leu Ser Leu Ser Pro Gly Lys
        355                 360 


<210> 137
<211> 1164
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized tissue Plasminogen Activator (otPA)
      pre-pro signal sequence and exons 7-10 of human
      IL-17RC, and Fc5
      

<400> 137
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt 60
tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagaggcag cctgtgggac 120
cccaacatca ccgtggagac cctggaggcc caccagctgc gtgtgagctt caccctgtgg 180
aacgaatcta cccattacca gatcctgctg accagttttc cgcacatgga gaaccacagt 240
tgctttgagc acatgcacca catacctgcg cccagaccag aagagttcca ccagcgatcc 300
aacgtcacac tcactctacg caaccttaaa gggtgctgtc gccaccaagt gcagatccag 360
cccttcttca gcagctgcct caatgactgc ctcagacact ccgcgactgt ttcctgccca 420
gaaatgccag acactccaga accaattccg gactacatgc ccctgtggga gcccaaatct 480
tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgaggg ggcaccgtca 540
gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 600
acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 660
gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 720
taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 780
aagtgcaagg tctccaacaa agccctccca tcctccatcg agaaaaccat ctccaaagcc 840
aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 900
aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 960
gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1020
tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag 1080
gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1140
agcctctccc tgtctccggg taaa                                        1164

<210> 138
<211> 388
<212> PRT
<213> Artificial Sequence

<220> 
<223> Optimized tissue Plasminogen Activator (otPA)
      pre-pro signal sequence and exons 7-10 of human
      IL-17RC, and Fc5
      

<400> 138
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg Gly Ser Leu Trp Asp Pro Asn Ile Thr Val Glu Thr Leu
        35                  40                  45              
Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp Asn Glu Ser Thr
    50                  55                  60                  
His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met Glu Asn His Ser
65                  70                  75                  80  
Cys Phe Glu His Met His His Ile Pro Ala Pro Arg Pro Glu Glu Phe
                85                  90                  95      
His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn Leu Lys Gly Cys
            100                 105                 110         
Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser Ser Cys Leu Asn
        115                 120                 125             
Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro Glu Met Pro Asp
    130                 135                 140                 
Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp Glu Pro Lys Ser
145                 150                 155                 160 
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu
                165                 170                 175     
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            180                 185                 190         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        195                 200                 205             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
    210                 215                 220                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
225                 230                 235                 240 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                245                 250                 255     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser
            260                 265                 270         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
        275                 280                 285             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
    290                 295                 300                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
305                 310                 315                 320 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                325                 330                 335     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
            340                 345                 350         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
        355                 360                 365             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    370                 375                 380                 
Ser Pro Gly Lys
385             


<210> 139
<211> 2433
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RA signal sequence and exons 1-10 of IL-17RA
      and exons 8-16 of human IL-17RC, and Fc5
      

<400> 139
atgggggccg cacgcagccc gccgtccgct gtcccggggc ccctgctggg gctgctcctg 60
ctgctcctgg gcgtgctggc cccgggtggc gcctccctgc gactcctgga ccaccgggcg 120
ctggtctgct cccagccggg gctaaactgc acggtcaaga atagtacctg cctggatgac 180
agctggattc accctcgaaa cctgaccccc tcctccccaa aggacctgca gatccagctg 240
cactttgccc acacccaaca aggagacctg ttccccgtgg ctcacatcga atggacactg 300
cagacagacg ccagcatcct gtacctcgag ggtgcagagt tatctgtcct gcagctgaac 360
accaatgaac gtttgtgcgt caggtttgag tttctgtcca aactgaggca tcaccacagg 420
cggtggcgtt ttaccttcag ccactttgtg gttgaccctg accaggaata tgaggtgacc 480
gttcaccacc tgcccaagcc catccctgat ggggacccaa accaccagtc caagaatttc 540
cttgtgcctg actgtgagca cgccaggatg aaggtaacca cgccatgcat gagctcaggc 600
agcctgtggg accccaacat caccgtggag accctggagg cccaccagct gcgtgtgagc 660
ttcaccctgt ggaacgaatc tacccattac cagatcctgc tgaccagttt tccgcacatg 720
gagaaccaca gttgctttga gcacatgcac cacatacctg cgcccagacc agaagagttc 780
caccagcgat ccaacgtcac actcactcta cgcaacctta aagggtgctg tcgccaccaa 840
gtgcagatcc agcccttctt cagcagctgc ctcaatgact gcctcagaca ctccgcgact 900
gtttcctgcc cagaaatgcc agacactcca gaaccaattc cggactacat gcccctgtgg 960
gccctgccct ggctcaacgt gtcagcagat ggtgacaacg tgcatctggt tctgaatgtc 1020
tctgaggagc agcacttcgg cctctccctg tactggaatc aggtccaggg ccccccaaaa 1080
ccccggtggc acaaaaacct gactggaccg cagatcatta ccttgaacca cacagacctg 1140
gttccctgcc tctgtattca ggtgtggcct ctggaacctg actccgttag gacgaacatc 1200
tgccccttca gggaggaccc ccgcgcacac cagaacctct ggcaagccgc ccgactgcga 1260
ctgctgaccc tgcagagctg gctgctggac gcaccgtgct cgctgcccgc agaagcggca 1320
ctgtgctggc gggctccggg tggggacccc tgccagccac tggtcccacc gctttcctgg 1380
gagaacgtca ctgtggacaa ggttctcgag ttcccattgc tgaaaggcca ccctaacctc 1440
tgtgttcagg tgaacagctc ggagaagctg cagctgcagg agtgcttgtg ggctgactcc 1500
ctggggcctc tcaaagacga tgtgctactg ttggagacac gaggccccca ggacaacaga 1560
tccctctgtg ccttggaacc cagtggctgt acttcactac ccagcaaagc ctccacgagg 1620
gcagctcgcc ttggagagta cttactacaa gacctgcagt caggccagtg tctgcagcta 1680
tgggacgatg acttgggagc gctatgggcc tgccccatgg acaaatacat ccacaaggag 1740
cccaaatctt cagacaaaac tcacacatgc ccaccgtgcc cagcacctga agccgagggg 1800
gcaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc 1860
cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac 1920
tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac 1980
aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc 2040
aaggagtaca agtgcaaggt ctccaacaaa gccctcccat cctccatcga gaaaaccatc 2100
tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat 2160
gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac 2220
atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc 2280
gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg 2340
tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac 2400
acgcagaaga gcctctccct gtctccgggt aaa                              2433

<210> 140
<211> 811
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RA signal sequence and exons 1-10 of IL-17RA
      and exons 8-16 of human IL-17RC, and Fc5
      

<400> 140
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu
 1               5                  10                  15      
Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser
            20                  25                  30          
Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu
        35                  40                  45              
Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His
    50                  55                  60                  
Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu
65                  70                  75                  80  
His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile
                85                  90                  95      
Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala
            100                 105                 110         
Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg
        115                 120                 125             
Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe
    130                 135                 140                 
Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr
145                 150                 155                 160 
Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln
                165                 170                 175     
Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val
            180                 185                 190         
Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr
        195                 200                 205             
Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp
    210                 215                 220                 
Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met
225                 230                 235                 240 
Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg
                245                 250                 255     
Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn
            260                 265                 270         
Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser
        275                 280                 285             
Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro
    290                 295                 300                 
Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp
305                 310                 315                 320 
Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu
                325                 330                 335     
Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp
            340                 345                 350         
Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr
        355                 360                 365             
Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu
    370                 375                 380                 
Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile
385                 390                 395                 400 
Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala
                405                 410                 415     
Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro
            420                 425                 430         
Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly
        435                 440                 445             
Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr
    450                 455                 460                 
Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu
465                 470                 475                 480 
Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu
                485                 490                 495     
Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu
            500                 505                 510         
Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser
        515                 520                 525             
Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu
    530                 535                 540                 
Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu
545                 550                 555                 560 
Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr
                565                 570                 575     
Ile His Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
            580                 585                 590         
Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro
        595                 600                 605             
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
    610                 615                 620                 
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
625                 630                 635                 640 
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                645                 650                 655     
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
            660                 665                 670         
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
        675                 680                 685             
Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
    690                 695                 700                 
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
705                 710                 715                 720 
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                725                 730                 735     
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
            740                 745                 750         
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
        755                 760                 765             
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
    770                 775                 780                 
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
785                 790                 795                 800 
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                805                 810     


<210> 141
<211> 2190
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RA signal sequence and exons 1-6 of IL-17RA
      and exons 8-13 of human IL-17RC and exons 7-10 of
      IL-17RA, and Fc5
      

<400> 141
atgggggccg cacgcagccc gccgtccgct gtcccggggc ccctgctggg gctgctcctg 60
ctgctcctgg gcgtgctggc cccgggtggc gcctccctgc gactcctgga ccaccgggcg 120
ctggtctgct cccagccggg gctaaactgc acggtcaaga atagtacctg cctggatgac 180
agctggattc accctcgaaa cctgaccccc tcctccccaa aggacctgca gatccagctg 240
cactttgccc acacccaaca aggagacctg ttccccgtgg ctcacatcga atggacactg 300
cagacagacg ccagcatcct gtacctcgag ggtgcagagt tatctgtcct gcagctgaac 360
accaatgaac gtttgtgcgt caggtttgag tttctgtcca aactgaggca tcaccacagg 420
cggtggcgtt ttaccttcag ccactttgtg gttgaccctg accaggaata tgaggtgacc 480
gttcaccacc tgcccaagcc catccctgat ggggacccaa accaccagtc caagaatttc 540
cttgtgcctg actgtgagca cgccaggatg aaggtaacca cgccatgcat gagctcagcc 600
ctgccctggc tcaacgtgtc agcagatggt gacaacgtgc atctggttct gaatgtctct 660
gaggagcagc acttcggcct ctccctgtac tggaatcagg tccagggccc cccaaaaccc 720
cggtggcaca aaaacctgac tggaccgcag atcattacct tgaaccacac agacctggtt 780
ccctgcctct gtattcaggt gtggcctctg gaacctgact ccgttaggac gaacatctgc 840
cccttcaggg aggacccccg cgcacaccag aacctctggc aagccgcccg actgcgactg 900
ctgaccctgc agagctggct gctggacgca ccgtgctcgc tgcccgcaga agcggcactg 960
tgctggcggg ctccgggtgg ggacccctgc cagccactgg tcccaccgct ttcctgggag 1020
aacgtcactg tggacaaggt tctcgagttc ccattgctga aaggccaccc taacctctgt 1080
gttcaggtga acagctcgga gaagctgcag ctgcaggagt gcttgtgggc tggcagcctg 1140
tgggacccca acatcaccgt ggagaccctg gaggcccacc agctgcgtgt gagcttcacc 1200
ctgtggaacg aatctaccca ttaccagatc ctgctgacca gttttccgca catggagaac 1260
cacagttgct ttgagcacat gcaccacata cctgcgccca gaccagaaga gttccaccag 1320
cgatccaacg tcacactcac tctacgcaac cttaaagggt gctgtcgcca ccaagtgcag 1380
atccagccct tcttcagcag ctgcctcaat gactgcctca gacactccgc gactgtttcc 1440
tgcccagaaa tgccagacac tccagaacca attccggact acatgcccct gtgggagccc 1500
aaatcttcag acaaaactca cacatgccca ccgtgcccag cacctgaagc cgagggggca 1560
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 1620
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 1680
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 1740
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 1800
gagtacaagt gcaaggtctc caacaaagcc ctcccatcct ccatcgagaa aaccatctcc 1860
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 1920
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 1980
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 2040
ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 2100
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 2160
cagaagagcc tctccctgtc tccgggtaaa                                  2190

<210> 142
<211> 730
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RA signal sequence and exons 1-6 of IL-17RA
      and exons 8-13 of human IL-17RC and exons 7-10 of
      IL-17RA, and Fc5
      

<400> 142
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu
 1               5                  10                  15      
Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser
            20                  25                  30          
Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu
        35                  40                  45              
Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His
    50                  55                  60                  
Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu
65                  70                  75                  80  
His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile
                85                  90                  95      
Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala
            100                 105                 110         
Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg
        115                 120                 125             
Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe
    130                 135                 140                 
Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr
145                 150                 155                 160 
Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln
                165                 170                 175     
Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val
            180                 185                 190         
Thr Thr Pro Cys Met Ser Ser Ala Leu Pro Trp Leu Asn Val Ser Ala
        195                 200                 205             
Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His
    210                 215                 220                 
Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro
225                 230                 235                 240 
Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His
                245                 250                 255     
Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro
            260                 265                 270         
Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala
        275                 280                 285             
His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln
    290                 295                 300                 
Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu
305                 310                 315                 320 
Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro
                325                 330                 335     
Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu
            340                 345                 350         
Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys
        355                 360                 365             
Leu Gln Leu Gln Glu Cys Leu Trp Ala Gly Ser Leu Trp Asp Pro Asn
    370                 375                 380                 
Ile Thr Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr
385                 390                 395                 400 
Leu Trp Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro
                405                 410                 415     
His Met Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala
            420                 425                 430         
Pro Arg Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu
        435                 440                 445             
Arg Asn Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe
    450                 455                 460                 
Phe Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser
465                 470                 475                 480 
Cys Pro Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro
                485                 490                 495     
Leu Trp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
            500                 505                 510         
Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
        515                 520                 525             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    530                 535                 540                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
545                 550                 555                 560 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                565                 570                 575     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            580                 585                 590         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        595                 600                 605             
Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    610                 615                 620                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
625                 630                 635                 640 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                645                 650                 655     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            660                 665                 670         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        675                 680                 685             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    690                 695                 700                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
705                 710                 715                 720 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                725                 730 


<210> 143
<211> 2124
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RA signal sequence and exons 1-3 of IL-17RA
      and exons 4-16 of human IL-17RC  and Fc5
      

<400> 143
atgggggccg cacgcagccc gccgtccgct gtcccggggc ccctgctggg gctgctcctg 60
ctgctcctgg gcgtgctggc cccgggtggc gcctccctgc gactcctgga ccaccgggcg 120
ctggtctgct cccagccggg gctaaactgc acggtcaaga atagtacctg cctggatgac 180
agctggattc accctcgaaa cctgaccccc tcctccccaa aggacctgca gatccagctg 240
cactttgccc acacccaaca aggagacctg ttccccgtgg ctcacatcga atggacactg 300
cagacagacg ggcactggga agagcctgaa gatgaggaaa agtttggagg agcagctgac 360
tcaggggtgg aggagcctag gaatgcctct ctccaggccc aagtcgtgct ctccttccag 420
gcctacccta ctgcccgctg cgtcctgctg gaggtgcaag tgcctgctgc ccttgtgcag 480
tttggtcagt ctgtgggctc tgtggtatat gactgcttcg aggctgccct agggagtgag 540
gtacgaatct ggtcctatac tcagcccagg tacgagaagg aactcaacca cacacagcag 600
ctgcctgact gcagggggct cgaagtctgg aattccatcc cgagctgctg ggccctgccc 660
tggctcaacg tgtcagcaga tggtgacaac gtgcatctgg ttctgaatgt ctctgaggag 720
cagcacttcg gcctctccct gtactggaat caggtccagg gccccccaaa accccggtgg 780
cacaaaaacc tgactggacc gcagatcatt accttgaacc acacagacct ggttccctgc 840
ctctgtattc aggtgtggcc tctggaacct gactccgtta ggacgaacat ctgccccttc 900
agggaggacc cccgcgcaca ccagaacctc tggcaagccg cccgactgcg actgctgacc 960
ctgcagagct ggctgctgga cgcaccgtgc tcgctgcccg cagaagcggc actgtgctgg 1020
cgggctccgg gtggggaccc ctgccagcca ctggtcccac cgctttcctg ggagaacgtc 1080
actgtggaca aggttctcga gttcccattg ctgaaaggcc accctaacct ctgtgttcag 1140
gtgaacagct cggagaagct gcagctgcag gagtgcttgt gggctgactc cctggggcct 1200
ctcaaagacg atgtgctact gttggagaca cgaggccccc aggacaacag atccctctgt 1260
gccttggaac ccagtggctg tacttcacta cccagcaaag cctccacgag ggcagctcgc 1320
cttggagagt acttactaca agacctgcag tcaggccagt gtctgcagct atgggacgat 1380
gacttgggag cgctatgggc ctgccccatg gacaaataca tccacaagga gcccaaatct 1440
tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgaggg ggcaccgtca 1500
gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 1560
acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 1620
gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 1680
taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 1740
aagtgcaagg tctccaacaa agccctccca tcctccatcg agaaaaccat ctccaaagcc 1800
aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1860
aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1920
gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1980
tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag 2040
gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 2100
agcctctccc tgtctccggg taaa                                        2124

<210> 144
<211> 708
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RA signal sequence and exons 1-3 of IL-17RA
      and exons 4-16 of human IL-17RC and Fc5
      

<400> 144
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu
 1               5                  10                  15      
Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser
            20                  25                  30          
Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu
        35                  40                  45              
Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His
    50                  55                  60                  
Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu
65                  70                  75                  80  
His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile
                85                  90                  95      
Glu Trp Thr Leu Gln Thr Asp Gly His Trp Glu Glu Pro Glu Asp Glu
            100                 105                 110         
Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro Arg Asn
        115                 120                 125             
Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr
    130                 135                 140                 
Ala Arg Cys Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln
145                 150                 155                 160 
Phe Gly Gln Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala
                165                 170                 175     
Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu
            180                 185                 190         
Lys Glu Leu Asn His Thr Gln Gln Leu Pro Asp Cys Arg Gly Leu Glu
        195                 200                 205             
Val Trp Asn Ser Ile Pro Ser Cys Trp Ala Leu Pro Trp Leu Asn Val
    210                 215                 220                 
Ser Ala Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu
225                 230                 235                 240 
Gln His Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro
                245                 250                 255     
Lys Pro Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu
            260                 265                 270         
Asn His Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu
        275                 280                 285             
Glu Pro Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro
    290                 295                 300                 
Arg Ala His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr
305                 310                 315                 320 
Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala
                325                 330                 335     
Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val
            340                 345                 350         
Pro Pro Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe
        355                 360                 365             
Pro Leu Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser
    370                 375                 380                 
Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro
385                 390                 395                 400 
Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn
                405                 410                 415     
Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser
            420                 425                 430         
Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp
        435                 440                 445             
Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala
    450                 455                 460                 
Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Lys Glu Pro Lys Ser
465                 470                 475                 480 
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu
                485                 490                 495     
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            500                 505                 510         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        515                 520                 525             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
    530                 535                 540                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
545                 550                 555                 560 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                565                 570                 575     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser
            580                 585                 590         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
        595                 600                 605             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
    610                 615                 620                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
625                 630                 635                 640 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                645                 650                 655     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
            660                 665                 670         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
        675                 680                 685             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    690                 695                 700                 
Ser Pro Gly Lys
705             


<210> 145
<211> 2127
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RA signal sequence and exon 1 of IL-17RA and
      exons 2-16 of human IL-17RC and Fc5
      

<400> 145
atgggggccg cacgcagccc gccgtccgct gtcccggggc ccctgctggg gctgctcctg 60
ctgctcctgg gcgtgctggc cccgggtggc gcctccctgc gactcctgga ccaccgggcg 120
ctggtctgct cccagccggg cctctcctgc cgcctctggg acagtgacat actctgcctg 180
cctggggaca tcgtgcctgc tccgggcccc gtgctggcgc ctacgcacct gcagacagag 240
ctggtgctga ggtgccagaa ggagaccgac tgtgacctct gtctgcgtgt ggctgtccac 300
ttggccgtgc atgggcactg ggaagagcct gaagatgagg aaaagtttgg aggagcagct 360
gactcagggg tggaggagcc taggaatgcc tctctccagg cccaagtcgt gctctccttc 420
caggcctacc ctactgcccg ctgcgtcctg ctggaggtgc aagtgcctgc tgcccttgtg 480
cagtttggtc agtctgtggg ctctgtggta tatgactgct tcgaggctgc cctagggagt 540
gaggtacgaa tctggtccta tactcagccc aggtacgaga aggaactcaa ccacacacag 600
cagctgcctg actgcagggg gctcgaagtc tggaattcca tcccgagctg ctgggccctg 660
ccctggctca acgtgtcagc agatggtgac aacgtgcatc tggttctgaa tgtctctgag 720
gagcagcact tcggcctctc cctgtactgg aatcaggtcc agggcccccc aaaaccccgg 780
tggcacaaaa acctgactgg accgcagatc attaccttga accacacaga cctggttccc 840
tgcctctgta ttcaggtgtg gcctctggaa cctgactccg ttaggacgaa catctgcccc 900
ttcagggagg acccccgcgc acaccagaac ctctggcaag ccgcccgact gcgactgctg 960
accctgcaga gctggctgct ggacgcaccg tgctcgctgc ccgcagaagc ggcactgtgc 1020
tggcgggctc cgggtgggga cccctgccag ccactggtcc caccgctttc ctgggagaac 1080
gtcactgtgg acaaggttct cgagttccca ttgctgaaag gccaccctaa cctctgtgtt 1140
caggtgaaca gctcggagaa gctgcagctg caggagtgct tgtgggctga ctccctgggg 1200
cctctcaaag acgatgtgct actgttggag acacgaggcc cccaggacaa cagatccctc 1260
tgtgccttgg aacccagtgg ctgtacttca ctacccagca aagcctccac gagggcagct 1320
cgccttggag agtacttact acaagacctg cagtcaggcc agtgtctgca gctatgggac 1380
gatgacttgg gagcgctatg ggcctgcccc atggacaaat acatccacaa ggagcccaaa 1440
tcttcagaca aaactcacac atgcccaccg tgcccagcac ctgaagccga gggggcaccg 1500
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1560
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1620
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1680
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1740
tacaagtgca aggtctccaa caaagccctc ccatcctcca tcgagaaaac catctccaaa 1800
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1860
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1920
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1980
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 2040
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2100
aagagcctct ccctgtctcc gggtaaa                                     2127

<210> 146
<211> 709
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RA signal sequence and exon 1 of IL-17RA and
      exons 2-16 of human IL-17RC and Fc5
      

<400> 146
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu
 1               5                  10                  15      
Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser
            20                  25                  30          
Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu
        35                  40                  45              
Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys Leu Pro Gly Asp Ile
    50                  55                  60                  
Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr His Leu Gln Thr Glu
65                  70                  75                  80  
Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys Asp Leu Cys Leu Arg
                85                  90                  95      
Val Ala Val His Leu Ala Val His Gly His Trp Glu Glu Pro Glu Asp
            100                 105                 110         
Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro Arg
        115                 120                 125             
Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro
    130                 135                 140                 
Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val
145                 150                 155                 160 
Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala
                165                 170                 175     
Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr
            180                 185                 190         
Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro Asp Cys Arg Gly Leu
        195                 200                 205             
Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala Leu Pro Trp Leu Asn
    210                 215                 220                 
Val Ser Ala Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu
225                 230                 235                 240 
Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro
                245                 250                 255     
Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr
            260                 265                 270         
Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro
        275                 280                 285             
Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp
    290                 295                 300                 
Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu
305                 310                 315                 320 
Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu
                325                 330                 335     
Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu
            340                 345                 350         
Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu
        355                 360                 365             
Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser
    370                 375                 380                 
Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly
385                 390                 395                 400 
Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp
                405                 410                 415     
Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro
            420                 425                 430         
Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln
        435                 440                 445             
Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly
    450                 455                 460                 
Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His Lys Glu Pro Lys
465                 470                 475                 480 
Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala
                485                 490                 495     
Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            500                 505                 510         
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        515                 520                 525             
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
    530                 535                 540                 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
545                 550                 555                 560 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                565                 570                 575     
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser
            580                 585                 590         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        595                 600                 605             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
    610                 615                 620                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
625                 630                 635                 640 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                645                 650                 655     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
            660                 665                 670         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
        675                 680                 685             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    690                 695                 700                 
Leu Ser Pro Gly Lys
705                 


<210> 147
<211> 2094
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal sequence and exons 1-16 of
      IL-17RCx4 with Cys194Ser and Cys202Ser
      substitutions and exons 2-16 of human IL-17RC and
      Fc5
      

<400> 147
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact ccagggggct cgaagtctgg 600
aattccatcc cgagctcctg ggccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agggaggacc cccgcgcaca ccagaacctc 900
tggcaagccg cccgactgcg actgctgacc ctgcagagct ggctgctgga cgcaccgtgc 960
tcgctgcccg cagaagcggc actgtgctgg cgggctccgg gtggggaccc ctgccagcca 1020
ctggtcccac cgctttcctg ggagaacgtc actgtggaca aggttctcga gttcccattg 1080
ctgaaaggcc accctaacct ctgtgttcag gtgaacagct cggagaagct gcagctgcag 1140
gagtgcttgt gggctgactc cctggggcct ctcaaagacg atgtgctact gttggagaca 1200
cgaggccccc aggacaacag atccctctgt gccttggaac ccagtggctg tacttcacta 1260
cccagcaaag cctccacgag ggcagctcgc cttggagagt acttactaca agacctgcag 1320
tcaggccagt gtctgcagct atgggacgat gacttgggag cgctatgggc ctgccccatg 1380
gacaaataca tccacaagga gcccaaatct tcagacaaaa ctcacacatg cccaccgtgc 1440
ccagcacctg aagccgaggg ggcaccgtca gtcttcctct tccccccaaa acccaaggac 1500
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 1560
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 1620
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 1680
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 1740
tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 1800
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 1860
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 1920
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 1980
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 2040
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       2094

<210> 148
<211> 698
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal sequence and exons 1-16 of
      IL-17RCx4 with Cys194Ser and Cys202Ser
      substitutions and exons 2-16 of human IL-17RC and
      Fc5
      

<400> 148
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Ser Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Ser Trp Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
    290                 295                 300                 
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
305                 310                 315                 320 
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
                325                 330                 335     
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
            340                 345                 350         
Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys
        355                 360                 365             
Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp
    370                 375                 380                 
Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr
385                 390                 395                 400 
Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly
                405                 410                 415     
Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly
            420                 425                 430         
Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp
        435                 440                 445             
Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile
    450                 455                 460                 
His Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
465                 470                 475                 480 
Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
                485                 490                 495     
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            500                 505                 510         
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
        515                 520                 525             
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
    530                 535                 540                 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
545                 550                 555                 560 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                565                 570                 575     
Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
            580                 585                 590         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
        595                 600                 605             
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    610                 615                 620                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
625                 630                 635                 640 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                645                 650                 655     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
            660                 665                 670         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
        675                 680                 685             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    690                 695             


<210> 149
<211> 2061
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RC signal sequence and exons 1-6 and 8-16 of
      IL-17RC with GlyGlyGlySer linker between exons 6
      and 8, and Fc5
      

<400> 149
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctggag gaggatccgc cctgccctgg 600
ctcaacgtgt cagcagatgg tgacaacgtg catctggttc tgaatgtctc tgaggagcag 660
cacttcggcc tctccctgta ctggaatcag gtccagggcc ccccaaaacc ccggtggcac 720
aaaaacctga ctggaccgca gatcattacc ttgaaccaca cagacctggt tccctgcctc 780
tgtattcagg tgtggcctct ggaacctgac tccgttagga cgaacatctg ccccttcagg 840
gaggaccccc gcgcacacca gaacctctgg caagccgccc gactgcgact gctgaccctg 900
cagagctggc tgctggacgc accgtgctcg ctgcccgcag aagcggcact gtgctggcgg 960
gctccgggtg gggacccctg ccagccactg gtcccaccgc tttcctggga gaacgtcact 1020
gtggacaagg ttctcgagtt cccattgctg aaaggccacc ctaacctctg tgttcaggtg 1080
aacagctcgg agaagctgca gctgcaggag tgcttgtggg ctgactccct ggggcctctc 1140
aaagacgatg tgctactgtt ggagacacga ggcccccagg acaacagatc cctctgtgcc 1200
ttggaaccca gtggctgtac ttcactaccc agcaaagcct ccacgagggc agctcgcctt 1260
ggagagtact tactacaaga cctgcagtca ggccagtgtc tgcagctatg ggacgatgac 1320
ttgggagcgc tatgggcctg ccccatggac aaatacatcc acaaggagcc caaatcttca 1380
gacaaaactc acacatgccc accgtgccca gcacctgaag ccgagggggc accgtcagtc 1440
ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1500
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1560
ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1620
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1680
tgcaaggtct ccaacaaagc cctcccatcc tccatcgaga aaaccatctc caaagccaaa 1740
gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag 1800
aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1860
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1920
gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg 1980
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2040
ctctccctgt ctccgggtaa a                                           2061

<210> 150
<211> 687
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RC signal sequence and exons 1-6 and 8-16 of
      IL-17RC with GlyGlyGlySer linker between exons 6
      and 8, and Fc5
      

<400> 150
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Gly Gly Gly Ser Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp
        195                 200                 205             
Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu
    210                 215                 220                 
Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His
225                 230                 235                 240 
Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu
                245                 250                 255     
Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val
            260                 265                 270         
Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn
        275                 280                 285             
Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu
    290                 295                 300                 
Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg
305                 310                 315                 320 
Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp
                325                 330                 335     
Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly
            340                 345                 350         
His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu
        355                 360                 365             
Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val
    370                 375                 380                 
Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala
385                 390                 395                 400 
Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg
                405                 410                 415     
Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln
            420                 425                 430         
Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro
        435                 440                 445             
Met Asp Lys Tyr Ile His Lys Glu Pro Lys Ser Ser Asp Lys Thr His
    450                 455                 460                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val
465                 470                 475                 480 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                485                 490                 495     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
            500                 505                 510         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        515                 520                 525             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
    530                 535                 540                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
545                 550                 555                 560 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile
                565                 570                 575     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            580                 585                 590         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        595                 600                 605             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    610                 615                 620                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
625                 630                 635                 640 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
                645                 650                 655     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            660                 665                 670         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        675                 680                 685         


<210> 151
<211> 2094
<212> DNA
<213> Artificial Sequence

<220> 
<223> otPA pre-pro signal sequence and exons 1-6 and
      8-16 of IL-17RC with a Leu21Ala substitution, and
      Fc5
      

<400> 151
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt 60
tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagagcaga gaggcttgtg 120
gggcctcagg acgctaccca ctgctctccg ggcctctcct gccgcctctg ggacagtgac 180
atactctgcc tgcctgggga catcgtgcct gctccgggcc ccgtgctggc gcctacgcac 240
ctgcagacag agctggtgct gaggtgccag aaggagaccg actgtgacct ctgtctgcgt 300
gtggctgtcc acttggccgt gcatgggcac tgggaagagc ctgaagatga ggaaaagttt 360
ggaggagcag ctgactcagg ggtggaggag cctaggaatg cctctctcca ggcccaagtc 420
gtgctctcct tccaggccta ccctactgcc cgctgcgtcc tgctggaggt gcaagtgcct 480
gctgcccttg tgcagtttgg tcagtctgtg ggctctgtgg tatatgactg cttcgaggct 540
gccctaggga gtgaggtacg aatctggtcc tatactcagc ccaggtacga gaaggaactc 600
aaccacacac agcagctgcc tgccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agggaggacc cccgcgcaca ccagaacctc 900
tggcaagccg cccgactgcg actgctgacc ctgcagagct ggctgctgga cgcaccgtgc 960
tcgctgcccg cagaagcggc actgtgctgg cgggctccgg gtggggaccc ctgccagcca 1020
ctggtcccac cgctttcctg ggagaacgtc actgtggaca aggttctcga gttcccattg 1080
ctgaaaggcc accctaacct ctgtgttcag gtgaacagct cggagaagct gcagctgcag 1140
gagtgcttgt gggctgactc cctggggcct ctcaaagacg atgtgctact gttggagaca 1200
cgaggccccc aggacaacag atccctctgt gccttggaac ccagtggctg tacttcacta 1260
cccagcaaag cctccacgag ggcagctcgc cttggagagt acttactaca agacctgcag 1320
tcaggccagt gtctgcagct atgggacgat gacttgggag cgctatgggc ctgccccatg 1380
gacaaataca tccacaagga gcccaaatct tcagacaaaa ctcacacatg cccaccgtgc 1440
ccagcacctg aagccgaggg ggcaccgtca gtcttcctct tccccccaaa acccaaggac 1500
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 1560
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 1620
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 1680
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 1740
tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 1800
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 1860
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 1920
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 1980
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 2040
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       2094

<210> 152
<211> 698
<212> PRT
<213> Artificial Sequence

<220> 
<223> otPA pre-pro signal sequence and exons 1-6 and
      8-16 of IL-17RC with a Leu21Ala substitution, and
      Fc5
      

<400> 152
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg Ala Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His Cys
        35                  40                  45              
Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys Leu
    50                  55                  60                  
Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr His
65                  70                  75                  80  
Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys Asp
                85                  90                  95      
Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp Glu
            100                 105                 110         
Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly Val
        115                 120                 125             
Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe
    130                 135                 140                 
Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val Pro
145                 150                 155                 160 
Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr Asp
                165                 170                 175     
Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr Thr
            180                 185                 190         
Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
    290                 295                 300                 
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
305                 310                 315                 320 
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
                325                 330                 335     
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
            340                 345                 350         
Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys
        355                 360                 365             
Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp
    370                 375                 380                 
Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr
385                 390                 395                 400 
Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly
                405                 410                 415     
Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly
            420                 425                 430         
Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp
        435                 440                 445             
Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile
    450                 455                 460                 
His Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
465                 470                 475                 480 
Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
                485                 490                 495     
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            500                 505                 510         
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
        515                 520                 525             
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
    530                 535                 540                 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
545                 550                 555                 560 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                565                 570                 575     
Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
            580                 585                 590         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
        595                 600                 605             
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    610                 615                 620                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
625                 630                 635                 640 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                645                 650                 655     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
            660                 665                 670         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
        675                 680                 685             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    690                 695             


<210> 153
<211> 2097
<212> DNA
<213> Artificial Sequence

<220> 
<223> Exons 1-6 and 8-16 of IL17RC with Ser215Thr and
      Ser228Thr substitutions
      

<400> 153
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt 60
tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagactgga gaggcttgtg 120
gggcctcagg acgctaccca ctgctctccg ggcctctcct gccgcctctg ggacagtgac 180
atactctgcc tgcctgggga catcgtgcct gctccgggcc ccgtgctggc gcctacgcac 240
ctgcagacag agctggtgct gaggtgccag aaggagaccg actgtgacct ctgtctgcgt 300
gtggctgtcc acttggccgt gcatgggcac tgggaagagc ctgaagatga ggaaaagttt 360
ggaggagcag ctgactcagg ggtggaggag cctaggaatg cctctctcca ggcccaagtc 420
gtgctctcct tccaggccta ccctactgcc cgctgcgtcc tgctggaggt gcaagtgcct 480
gctgcccttg tgcagtttgg tcagtctgtg ggctctgtgg tatatgactg cttcgaggct 540
gccctaggga gtgaggtacg aatctggtcc tatactcagc ccaggtacga gaaggaactc 600
aaccacacac agcagctgcc tgccctgccc tggctcaacg tgacagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt cacagaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agggaggacc cccgcgcaca ccagaacctc 900
tggcaagccg cccgactgcg actgctgacc ctgcagagct ggctgctgga cgcaccgtgc 960
tcgctgcccg cagaagcggc actgtgctgg cgggctccgg gtggggaccc ctgccagcca 1020
ctggtcccac cgctttcctg ggagaacgtc actgtggaca aggttctcga gttcccattg 1080
ctgaaaggcc accctaacct ctgtgttcag gtgaacagct cggagaagct gcagctgcag 1140
gagtgcttgt gggctgactc cctggggcct ctcaaagacg atgtgctact gttggagaca 1200
cgaggccccc aggacaacag atccctctgt gccttggaac ccagtggctg tacttcacta 1260
cccagcaaag cctccacgag ggcagctcgc cttggagagt acttactaca agacctgcag 1320
tcaggccagt gtctgcagct atgggacgat gacttgggag cgctatgggc ctgccccatg 1380
gacaaataca tccacaagga gcccaaatct tcagacaaaa ctcacacatg cccaccgtgc 1440
ccagcacctg aagccgaggg ggcaccgtca gtcttcctct tccccccaaa acccaaggac 1500
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 1560
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 1620
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 1680
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 1740
tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 1800
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 1860
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 1920
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 1980
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 2040
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaataa    2097

<210> 154
<211> 698
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exons 1-6 and 8-16 of IL17RC with Ser215Thr and
      Ser228Thr substitutions and Fc5
      

<400> 154
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His Cys
        35                  40                  45              
Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys Leu
    50                  55                  60                  
Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr His
65                  70                  75                  80  
Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys Asp
                85                  90                  95      
Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp Glu
            100                 105                 110         
Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly Val
        115                 120                 125             
Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser Phe
    130                 135                 140                 
Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val Pro
145                 150                 155                 160 
Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr Asp
                165                 170                 175     
Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr Thr
            180                 185                 190         
Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Thr Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Thr Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
    290                 295                 300                 
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
305                 310                 315                 320 
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
                325                 330                 335     
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
            340                 345                 350         
Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys
        355                 360                 365             
Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp
    370                 375                 380                 
Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr
385                 390                 395                 400 
Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly
                405                 410                 415     
Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly
            420                 425                 430         
Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp
        435                 440                 445             
Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile
    450                 455                 460                 
His Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
465                 470                 475                 480 
Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
                485                 490                 495     
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            500                 505                 510         
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
        515                 520                 525             
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
    530                 535                 540                 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
545                 550                 555                 560 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                565                 570                 575     
Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
            580                 585                 590         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
        595                 600                 605             
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    610                 615                 620                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
625                 630                 635                 640 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                645                 650                 655     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
            660                 665                 670         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
        675                 680                 685             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    690                 695             


<210> 155
<211> 2094
<212> DNA
<213> Artificial Sequence

<220> 
<223> Exons 1-6 and 8-16 of IL17RC with Ser to Thr
      substitutions and at residues 120, 215, 228, 374,
      and 408 and Fc5
      

<400> 155
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt 60
tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagactgga gaggcttgtg 120
gggcctcagg acgctaccca ctgctctccg ggcctctcct gccgcctctg ggacagtgac 180
atactctgcc tgcctgggga catcgtgcct gctccgggcc ccgtgctggc gcctacgcac 240
ctgcagacag agctggtgct gaggtgccag aaggagaccg actgtgacct ctgtctgcgt 300
gtggctgtcc acttggccgt gcatgggcac tgggaagagc ctgaagatga ggaaaagttt 360
ggaggagcag ctgactcagg ggtggaggag cctaggaatg ccacactcca ggcccaagtc 420
gtgctctcct tccaggccta ccctactgcc cgctgcgtcc tgctggaggt gcaagtgcct 480
gctgcccttg tgcagtttgg tcagtctgtg ggctctgtgg tatatgactg cttcgaggct 540
gccctaggga gtgaggtacg aatctggtcc tatactcagc ccaggtacga gaaggaactc 600
aaccacacac agcagctgcc tgccctgccc tggctcaacg tgacagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt cacagaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agggaggacc cccgcgcaca ccagaacctc 900
tggcaagccg cccgactgcg actgctgacc ctgcagagct ggctgctgga cgcaccgtgc 960
tcgctgcccg cagaagcggc actgtgctgg cgggctccgg gtggggaccc ctgccagcca 1020
ctggtcccac cgctttcctg ggagaacgtc actgtggaca aggttctcga gttcccattg 1080
ctgaaaggcc accctaacct ctgtgttcag gtgaacagca cagagaagct gcagctgcag 1140
gagtgcttgt gggctgactc cctggggcct ctcaaagacg atgtgctact gttggagaca 1200
cgaggccccc aggacaacag aacactctgt gccttggaac ccagtggctg tacttcacta 1260
cccagcaaag cctccacgag ggcagctcgc cttggagagt acttactaca agacctgcag 1320
tcaggccagt gtctgcagct atgggacgat gacttgggag cgctatgggc ctgccccatg 1380
gacaaataca tccacaagga gcccaaatct tcagacaaaa ctcacacatg cccaccgtgc 1440
ccagcacctg aagccgaggg ggcaccgtca gtcttcctct tccccccaaa acccaaggac 1500
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 1560
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 1620
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 1680
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 1740
tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 1800
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 1860
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 1920
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 1980
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 2040
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       2094

<210> 156
<211> 698
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exons 1-6 and 8-16 of IL17RC with Ser to Thr
      substitutions at residues 120, 215, 228, 374, and
      408 and Fc5
      

<400> 156
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His Cys
        35                  40                  45              
Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys Leu
    50                  55                  60                  
Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr His
65                  70                  75                  80  
Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys Asp
                85                  90                  95      
Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp Glu
            100                 105                 110         
Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly Val
        115                 120                 125             
Glu Glu Pro Arg Asn Ala Thr Leu Gln Ala Gln Val Val Leu Ser Phe
    130                 135                 140                 
Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val Pro
145                 150                 155                 160 
Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr Asp
                165                 170                 175     
Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr Thr
            180                 185                 190         
Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Thr Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Thr Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
    290                 295                 300                 
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
305                 310                 315                 320 
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
                325                 330                 335     
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
            340                 345                 350         
Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys
        355                 360                 365             
Val Gln Val Asn Ser Thr Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp
    370                 375                 380                 
Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr
385                 390                 395                 400 
Arg Gly Pro Gln Asp Asn Arg Thr Leu Cys Ala Leu Glu Pro Ser Gly
                405                 410                 415     
Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly
            420                 425                 430         
Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp
        435                 440                 445             
Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile
    450                 455                 460                 
His Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
465                 470                 475                 480 
Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro
                485                 490                 495     
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            500                 505                 510         
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
        515                 520                 525             
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
    530                 535                 540                 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
545                 550                 555                 560 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                565                 570                 575     
Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
            580                 585                 590         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
        595                 600                 605             
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    610                 615                 620                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
625                 630                 635                 640 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                645                 650                 655     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
            660                 665                 670         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
        675                 680                 685             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    690                 695             


<210> 157
<211> 2070
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-17RA signal peptide and exons 1-6 of IL-17RA
      and exons 8-16 of IL-17RC and Fc5
      

<400> 157
atgggggccg cacgcagccc gccgtccgct gtcccggggc ccctgctggg gctgctcctg 60
ctgctcctgg gcgtgctggc cccgggtggc gcctccctgc gactcctgga ccaccgggcg 120
ctggtctgct cccagccggg gctaaactgc acggtcaaga atagtacctg cctggatgac 180
agctggattc accctcgaaa cctgaccccc tcctccccaa aggacctgca gatccagctg 240
cactttgccc acacccaaca aggagacctg ttccccgtgg ctcacatcga atggacactg 300
cagacagacg ccagcatcct gtacctcgag ggtgcagagt tatctgtcct gcagctgaac 360
accaatgaac gtttgtgcgt caggtttgag tttctgtcca aactgaggca tcaccacagg 420
cggtggcgtt ttaccttcag ccactttgtg gttgaccctg accaggaata tgaggtgacc 480
gttcaccacc tgcccaagcc catccctgat ggggacccaa accaccagtc caagaatttc 540
cttgtgcctg actgtgagca cgccaggatg aaggtaacca cgccatgcat gagctcagcc 600
ctgccctggc tcaacgtgtc agcagatggt gacaacgtgc atctggttct gaatgtctct 660
gaggagcagc acttcggcct ctccctgtac tggaatcagg tccagggccc cccaaaaccc 720
cggtggcaca aaaacctgac tggaccgcag atcattacct tgaaccacac agacctggtt 780
ccctgcctct gtattcaggt gtggcctctg gaacctgact ccgttaggac gaacatctgc 840
cccttcaggg aggacccccg cgcacaccag aacctctggc aagccgcccg actgcgactg 900
ctgaccctgc agagctggct gctggacgca ccgtgctcgc tgcccgcaga agcggcactg 960
tgctggcggg ctccgggtgg ggacccctgc cagccactgg tcccaccgct ttcctgggag 1020
aacgtcactg tggacaaggt tctcgagttc ccattgctga aaggccaccc taacctctgt 1080
gttcaggtga acagctcgga gaagctgcag ctgcaggagt gcttgtgggc tgactccctg 1140
gggcctctca aagacgatgt gctactgttg gagacacgag gcccccagga caacagatcc 1200
ctctgtgcct tggaacccag tggctgtact tcactaccca gcaaagcctc cacgagggca 1260
gctcgccttg gagagtactt actacaagac ctgcagtcag gccagtgtct gcagctatgg 1320
gacgatgact tgggagcgct atgggcctgc cccatggaca aatacatcca caaggagccc 1380
aaatcttcag acaaaactca cacatgccca ccgtgcccag cacctgaagc cgagggggca 1440
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 1500
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 1560
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 1620
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 1680
gagtacaagt gcaaggtctc caacaaagcc ctcccatcct ccatcgagaa aaccatctcc 1740
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 1800
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 1860
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 1920
ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 1980
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 2040
cagaagagcc tctccctgtc tccgggtaaa                                  2070

<210> 158
<211> 690
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-17RA signal peptide and exons 1-6 of IL-17RA
      and exons 8-16 of IL-17RC and Fc5
      

<400> 158
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu
 1               5                  10                  15      
Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser
            20                  25                  30          
Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu
        35                  40                  45              
Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His
    50                  55                  60                  
Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu
65                  70                  75                  80  
His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile
                85                  90                  95      
Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala
            100                 105                 110         
Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg
        115                 120                 125             
Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe
    130                 135                 140                 
Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr
145                 150                 155                 160 
Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln
                165                 170                 175     
Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val
            180                 185                 190         
Thr Thr Pro Cys Met Ser Ser Ala Leu Pro Trp Leu Asn Val Ser Ala
        195                 200                 205             
Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His
    210                 215                 220                 
Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro
225                 230                 235                 240 
Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His
                245                 250                 255     
Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro
            260                 265                 270         
Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala
        275                 280                 285             
His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln
    290                 295                 300                 
Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu
305                 310                 315                 320 
Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro
                325                 330                 335     
Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu
            340                 345                 350         
Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys
        355                 360                 365             
Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys
    370                 375                 380                 
Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser
385                 390                 395                 400 
Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala
                405                 410                 415     
Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln
            420                 425                 430         
Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp
        435                 440                 445             
Ala Cys Pro Met Asp Lys Tyr Ile His Lys Glu Pro Lys Ser Ser Asp
    450                 455                 460                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala
465                 470                 475                 480 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                485                 490                 495     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            500                 505                 510         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        515                 520                 525             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    530                 535                 540                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
545                 550                 555                 560 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu
                565                 570                 575     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            580                 585                 590         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
        595                 600                 605             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    610                 615                 620                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
625                 630                 635                 640 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                645                 650                 655     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
            660                 665                 670         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
        675                 680                 685             
Gly Lys
    690 


<210> 159
<211> 252
<212> DNA
<213> Artificial Sequence

<220> 
<223> Domain 1
      

<400> 159
gccctgccct ggctcaacgt gtcagcagat ggtgacaacg tgcatctggt tctgaatgtc 60
tctgaggagc agcacttcgg cctctccctg tactggaatc aggtccaggg ccccccaaaa 120
ccccggtggc acaaaaacct gactggaccg cagatcatta ccttgaacca cacagacctg 180
gttccctgcc tctgtattca ggtgtggcct ctggaacctg actccgttag gacgaacatc 240
tgccccttca gg                                                     252

<210> 160
<211> 84
<212> PRT
<213> Artificial Sequence

<220> 
<223> Domain 1
      

<400> 160
Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu
 1               5                  10                  15      
Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp
            20                  25                  30          
Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr
        35                  40                  45              
Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu
    50                  55                  60                  
Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile
65                  70                  75                  80  
Cys Pro Phe Arg
                


<210> 161
<211> 282
<212> DNA
<213> Artificial Sequence

<220> 
<223> Domain 2
      

<400> 161
gaggaccccc gcgcacacca gaacctctgg caagccgccc gactgcgact gctgaccctg 60
cagagctggc tgctggacgc accgtgctcg ctgcccgcag aagcggcact gtgctggcgg 120
gctccgggtg gggacccctg ccagccactg gtcccaccgc tttcctggga gaacgtcact 180
gtggacaagg ttctcgagtt cccattgctg aaaggccacc ctaacctctg tgttcaggtg 240
aacagctcgg agaagctgca gctgcaggag tgcttgtggg ct                    282

<210> 162
<211> 94
<212> PRT
<213> Artificial Sequence

<220> 
<223> Domain 2
      

<400> 162
Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg
 1               5                  10                  15      
Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro
            20                  25                  30          
Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln
        35                  40                  45              
Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val
    50                  55                  60                  
Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys Val Gln Val
65                  70                  75                  80  
Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala
                85                  90                  


<210> 163
<211> 231
<212> DNA
<213> Artificial Sequence

<220> 
<223> Domain 3
      

<400> 163
gactccctgg ggcctctcaa agacgatgtg ctactgttgg agacacgagg cccccaggac 60
aacagatccc tctgtgcctt ggaacccagt ggctgtactt cactacccag caaagcctcc 120
acgagggcag ctcgccttgg agagtactta ctacaagacc tgcagtcagg ccagtgtctg 180
cagctatggg acgatgactt gggagcgcta tgggcctgcc ccatggacaa a          231

<210> 164
<211> 77
<212> PRT
<213> Artificial Sequence

<220> 
<223> Domain 3
      

<400> 164
Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg
 1               5                  10                  15      
Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys
            20                  25                  30          
Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu
        35                  40                  45              
Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp
    50                  55                  60                  
Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys
65                  70                  75          


<210> 165
<211> 2124
<212> DNA
<213> homo sapians

<400> 165
atgcctgtgc cctggttctt gctgtccttg gcactgggcc gaagcccagt ggtcctttct 60
ctggagaggc ttgtggggcc tcaggacgct acccactgct ctccgggcct ctcctgccgc 120
ctctgggaca gtgacatact ctgcctgcct ggggacatcg tgcctgctcc gggccccgtg 180
ctggcgccta cgcacctgca gacagagctg gtgctgaggt gccagaagga gaccgactgt 240
gacctctgtc tgcgtgtggc tgtccacttg gccgtgcatg ggcactggga agagcctgaa 300
gatgaggaaa agtttggagg agcagctgac tcaggggtgg aggagcctag gaatgcctct 360
ctccaggccc aagtcgtgct ctccttccag gcctacccta ctgcccgctg cgtcctgctg 420
gaggtgcaag tgcctgctgc ccttgtgcag tttggtcagt ctgtgggctc tgtggtatat 480
gactgcttcg aggctgccct agggagtgag gtacgaatct ggtcctatac tcagcccagg 540
tacgagaagg aactcaacca cacacagcag ctgcctgact gcagggggct cgaagtctgg 600
aacagcatcc cgagctgctg ggccctgccc tggctcaacg tgtcagcaga tggtgacaac 660
gtgcatctgg ttctgaatgt ctctgaggag cagcacttcg gcctctccct gtactggaat 720
caggtccagg gccccccaaa accccggtgg cacaaaaacc tgactggacc gcagatcatt 780
accttgaacc acacagacct ggttccctgc ctctgtattc aggtgtggcc tctggaacct 840
gactccgtta ggacgaacat ctgccccttc agggaggacc cccgcgcaca ccagaacctc 900
tggcaagccg cccgactgcg actgctgacc ctgcagagct ggctgctgga cgcaccgtgc 960
tcgctgcccg cagaagcggc actgtgctgg cgggctccgg gtggggaccc ctgccagcca 1020
ctggtcccac cgctttcctg ggagaacgtc actgtggaca aggttctcga gttcccattg 1080
ctgaaaggcc accctaacct ctgtgttcag gtgaacagct cggagaagct gcagctgcag 1140
gagtgcttgt gggctgactc cctggggcct ctcaaagacg atgtgctact gttggagaca 1200
cgaggccccc aggacaacag atccctctgt gccttggaac ccagtggctg tacttcacta 1260
cccagcaaag cctccacgag ggcagctcgc cttggagagt acttactaca agacctgcag 1320
tcaggccagt gtctgcagct atgggacgat gacttgggag cgctatgggc ctgccccatg 1380
gacaaataca tccacaagcg ctgggccctc gtgtggctgg cctgcctact ctttgccgct 1440
gcgctttccc tcatcctcct tctcaaaaag gatcacgcga aagcggccgc caggggccgc 1500
gcggctctgc tcctctactc agccgatgac tcgggtttcg agcgcctggt gggcgccctg 1560
gcgtcggccc tgtgccagct gccgctgcgc gtggccgtag acctgtggag ccgtcgtgaa 1620
ctgagcgcgc aggggcccgt ggcttggttt cacgcgcagc ggcgccagac cctgcaggag 1680
ggcggcgtgg tggtcttgct cttctctccc ggtgcggtgg cgctgtgcag cgagtggcta 1740
caggatgggg tgtccgggcc cggggcgcac ggcccgcacg acgccttccg cgcctcgctc 1800
agctgcgtgc tgcccgactt cttgcagggc cgggcgcccg gcagctacgt gggggcctgc 1860
ttcgacaggc tgctccaccc ggacgccgta cccgcccttt tccgcaccgt gcccgtcttc 1920
acactgccct cccaactgcc agacttcctg ggggccctgc agcagcctcg cgccccgcgt 1980
tccgggcggc tccaagagag agcggagcaa gtgtcccggg cccttcagcc agccctggat 2040
agctacttcc atcccccggg gactcccgcg ccgggacgcg gggtgggacc aggggcggga 2100
cctggggcgg gggacgggac ttaa                                        2124

<210> 166
<211> 707
<212> PRT
<213> homo sapians

<400> 166
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro
 1               5                  10                  15      
Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His
            20                  25                  30          
Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys
        35                  40                  45              
Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr
    50                  55                  60                  
His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys
65                  70                  75                  80  
Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp
                85                  90                  95      
Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly
            100                 105                 110         
Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser
        115                 120                 125             
Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val
    130                 135                 140                 
Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr
145                 150                 155                 160 
Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr
                165                 170                 175     
Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro
            180                 185                 190         
Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala
        195                 200                 205             
Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val
    210                 215                 220                 
Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn
225                 230                 235                 240 
Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly
                245                 250                 255     
Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys
            260                 265                 270         
Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys
        275                 280                 285             
Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala
    290                 295                 300                 
Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys
305                 310                 315                 320 
Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp
                325                 330                 335     
Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val
            340                 345                 350         
Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys
        355                 360                 365             
Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp
    370                 375                 380                 
Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr
385                 390                 395                 400 
Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly
                405                 410                 415     
Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly
            420                 425                 430         
Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp
        435                 440                 445             
Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile
    450                 455                 460                 
His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala
465                 470                 475                 480 
Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Ala Ala
                485                 490                 495     
Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly
            500                 505                 510         
Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro
        515                 520                 525             
Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln
    530                 535                 540                 
Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu
545                 550                 555                 560 
Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys
                565                 570                 575     
Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro
            580                 585                 590         
His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu
        595                 600                 605             
Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu
    610                 615                 620                 
Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe
625                 630                 635                 640 
Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro
                645                 650                 655     
Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser
            660                 665                 670         
Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr
        675                 680                 685             
Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly
    690                 695                 700                 
Asp Gly Thr
705         


<210> 167
<211> 3120
<212> DNA
<213> homo sapians

<400> 167
ggggccgagc cctccgcgac gccacccggg ccatgggggc cgcacgcagc ccgccgtccg 60
ctgtcccggg gcccctgctg gggctgctcc tgctgctcct gggcgtgctg gccccgggtg 120
gcgcctccct gcgactcctg gaccaccggg cgctggtctg ctcccagccg gggctaaact 180
gcacggtcaa gaatagtacc tgcctggatg acagctggat tcaccctcga aacctgaccc 240
cctcctcccc aaaggacctg cagatccagc tgcactttgc ccacacccaa caaggagacc 300
tgttccccgt ggctcacatc gaatggacac tgcagacaga cgccagcatc ctgtacctcg 360
agggtgcaga gttatctgtc ctgcagctga acaccaatga acgtttgtgc gtcaggtttg 420
agtttctgtc caaactgagg catcaccaca ggcggtggcg ttttaccttc agccactttg 480
tggttgaccc tgaccaggaa tatgaggtga ccgttcacca cctgcccaag cccatccctg 540
atggggaccc aaaccaccag tccaagaatt tccttgtgcc tgactgtgag cacgccagga 600
tgaaggtaac cacgccatgc atgagctcag gcagcctgtg ggaccccaac atcaccgtgg 660
agaccctgga ggcccaccag ctgcgtgtga gcttcaccct gtggaacgaa tctacccatt 720
accagatcct gctgaccagt tttccgcaca tggagaacca cagttgcttt gagcacatgc 780
accacatacc tgcgcccaga ccagaagagt tccaccagcg atccaacgtc acactcactc 840
tacgcaacct taaagggtgc tgtcgccacc aagtgcagat ccagcccttc ttcagcagct 900
gcctcaatga ctgcctcaga cactccgcga ctgtttcctg cccagaaatg ccagacactc 960
cagaaccaat tccggactac atgcccctgt gggtgtactg gttcatcacg ggcatctcca 1020
tcctgctggt gggctccgtc atcctgctca tcgtctgcat gacctggagg ctagctgggc 1080
ctggaagtga aaaatacagt gatgacacca aatacaccga tggcctgcct gcggctgacc 1140
tgatcccccc accgctgaag cccaggaagg tctggatcat ctactcagcc gaccaccccc 1200
tctacgtgga cgtggtcctg aaattcgccc agttcctgct caccgcctgc ggcacggaag 1260
tggccctgga cctgctggaa gagcaggcca tctcggaggc aggagtcatg acctgggtgg 1320
gccgtcagaa gcaggagatg gtggagagca actctaagat catcgtcctg tgctcccgcg 1380
gcacgcgcgc caagtggcag gcgctcctgg gccggggggc gcctgtgcgg ctgcgctgcg 1440
accacggaaa gcccgtgggg gacctgttca ctgcagccat gaacatgatc ctcccggact 1500
tcaagaggcc agcctgcttc ggcacctacg tagtctgcta cttcagcgag gtcagctgtg 1560
acggcgacgt ccccgacctg ttcggcgcgg cgccgcggta cccgctcatg gacaggttcg 1620
aggaggtgta cttccgcatc caggacctgg agatgttcca gccgggccgc atgcaccgcg 1680
taggggagct gtcgggggac aactacctgc ggagcccggg cggcaggcag ctccgcgccg 1740
ccctggacag gttccgggac tggcaggtcc gctgtcccga ctggttcgaa tgtgagaacc 1800
tctactcagc agatgaccag gatgccccgt ccctggacga agaggtgttt gaggagccac 1860
tgctgcctcc gggaaccggc atcgtgaagc gggcgcccct ggtgcgcgag cctggctccc 1920
aggcctgcct ggccatagac ccgctggtcg gggaggaagg aggagcagca gtggcaaagc 1980
tggaacctca cctgcagccc cggggtcagc cagcgccgca gcccctccac accctggtgc 2040
tcgccgcaga ggagggggcc ctggtggccg cggtggagcc tgggcccctg gctgacggtg 2100
ccgcagtccg gctggcactg gcgggggagg gcgaggcctg cccgctgctg ggcagcccgg 2160
gcgctgggcg aaatagcgtc ctcttcctcc ccgtggaccc cgaggactcg ccccttggca 2220
gcagcacccc catggcgtct cctgacctcc ttccagagga cgtgagggag cacctcgaag 2280
gcttgatgct ctcgctcttc gagcagagtc tgagctgcca ggcccagggg ggctgcagta 2340
gacccgccat ggtcctcaca gacccacaca cgccctacga ggaggagcag cggcagtcag 2400
tgcagtctga ccagggctac atctccagga gctccccgca gccccccgag ggactcacgg 2460
aaatggagga agaggaggaa gaggagcagg acccagggaa gccggccctg ccactctctc 2520
ccgaggacct ggagagcctg aggagcctcc agcggcagct gcttttccgc cagctgcaga 2580
agaactcggg ctgggacacg atggggtcag agtcagaggg gcccagtgca tgagggcggc 2640
tccccaggga ccgcccagat cccagctttg agagaggagt gtgtgtgcac gtattcatct 2700
gtgtgtacat gtctgcatgt gtatatgttc gtgtgtgaaa tgtaggcttt aaaatgtaaa 2760
tgtctggatt ttaatcccag gcatccctcc taacttttct ttgtgcagcg gtctggttat 2820
cgtctatccc caggggaatc cacacagccc gctcccagga gctaatggta gagcgtcctt 2880
gaggctccat tattcgttca ttcagcattt attgtgcacc tactatgtgg cgggcatttg 2940
ggataccaag ataaattgca tgcggcatgg ccccagccat gaaggaactt aaccgctagt 3000
gccgaggaca cgttaaacga acaggatggg ccgggcacgg tggctcacgc ctgtaatccc 3060
agcacactgg gaggccgagg caggtggatc actctgaggt caggagtttg agccagcctg 3120


<210> 168
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> human growth hormone signal peptide
      

<220> 
<221> CDS            
<222> (1)...(78)

<400> 168
atg gct aca ggc tcc cgg acg tcc ctg ctc ctg gct ttt ggc ctg ctc   48
Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu
 1               5                   10                  15
 
tgc ctg ccc tgg ctt caa gag ggc agt gcc                           78
Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala
             20                  25
 

<210> 169
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> human growth hormone signal peptide

<400> 169
Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu
 1               5                  10                  15      
Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala
            20                  25      


<210> 170
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> Mouse Immunoglobulin Heavy Chain Variable Region
      (VH 26-10) Signal Peptide
      

<220> 
<221> CDS            
<222> (1)...(57)

<400> 170
atg gga tgg agc tgg atc ttt ctc ttt ctt ctg tca gga act gca ggt   48
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly
 1               5                   10                  15
 
gtc ctc tct                                                       57
Val Leu Ser

 

<210> 171
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse Immunoglobulin Heavy Chain Variable Region
      (VH 26-10) Signal Peptide
      

<400> 171
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly
 1               5                  10                  15      
Val Leu Ser
            


<210> 172
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Human CD33 Signal Peptide
      

<220> 
<221> CDS            
<222> (1)...(48)

<400> 172
atg ccg ctg ctg cta ctg ctg ccc ctg ctg tgg gca ggg gcc ctg gct   48
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala
 1               5                   10                  15
 


<210> 173
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human CD33 Signal Peptide

<400> 173
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala
 1               5                  10                  15      


<210> 174
<211> 696
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fc10 immunoglobulin heavy chain constant region

<220> 
<221> CDS            
<222> (1)...(696)

<400> 174
gag ccc aaa tct tca gac aaa act cac aca tgc cca ccg tgc cca gca   48
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                   10                  15
 
cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc   96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
             20                  25                  30
 
aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg   144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
         35                  40                  45
 
gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg   192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
     50                  55                  60
 
gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag   240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
 65                  70                  75                  80
 
tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag   288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                 85                  90                  95
 
gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc   336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110
 
ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc   384
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125
 
cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc   432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140
 
aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc   480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160
 
gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac   528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175
 
aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac   576
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190
 
agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc   624
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205
 
tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag   672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220
 
agc ctc tcc ctg tct ccg ggt aaa                                   696
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230
 

<210> 175
<211> 232
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc10 immunoglobulin heavy chain constant region

<400> 175
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         


<210> 176
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> linker

<220> 
<221> CDS            
<222> (1)...(60)

<400> 176
gga ggt ggg ggc tcc ggc ggg ggt gga agc ggt gga ggc ggg tcg ggg   48
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
 1               5                   10                  15
 
ggc gga ggt agt                                                   60
Gly Gly Gly Ser
             20
 

<210> 177
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker

<400> 177
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
 1               5                  10                  15      
Gly Gly Gly Ser
            20  


<210> 178
<211> 35
<212> PRT
<213> Artificial Sequence

<220> 
<223> pre-pro signal sequence from otPA

<400> 178
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg
        35  


<210> 179
<211> 696
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fc5 immunoglobulin heavy chain constant region

<220> 
<221> CDS            
<222> (1)...(696)

<400> 179
gag ccc aaa tct tca gac aaa act cac aca tgc cca ccg tgc cca gca   48
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                   10                  15
 
cct gaa gcc gag ggg gca ccg tca gtc ttc ctc ttc ccc cca aaa ccc   96
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
             20                  25                  30
 
aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg   144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
         35                  40                  45
 
gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg   192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
     50                  55                  60
 
gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag   240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
 65                  70                  75                  80
 
tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag   288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                 85                  90                  95
 
gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc   336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110
 
ctc cca tcc tcc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc   384
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125
 
cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc   432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140
 
aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc   480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160
 
gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac   528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175
 
aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac   576
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190
 
agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc   624
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205
 
tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag   672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220
 
agc ctc tcc ctg tct ccg ggt aaa                                   696
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230
 

<210> 180
<211> 232
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc5 immunoglobulin heavy chain constant region

<400> 180
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         


<210> 181
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Murine Il-17RA signal peptide

<400> 181
Met Ala Ile Arg Arg Cys Trp Pro Arg Val Val Pro Gly Pro Ala Leu
 1               5                  10                  15      
Gly Trp Leu Leu Leu Leu Leu Asn Val Leu Ala Pro Gly Arg Ala
            20                  25                  30      


<210> 182
<211> 1974
<212> DNA
<213> Artificial Sequence

<220> 
<221> CDS            
<222> (1)...(1974)

<220> 
<223> Exons 1-6 of IL-17RA with an N-terminal Serine
      deletion, exons 8-16 of IL-17RC and Fc5

<400> 182
ctg cga ctc ctg gac cac cgg gcg ctg gtc tgc tcc cag ccg ggg cta   48
Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu
 1               5                   10                  15
 
aac tgc acg gtc aag aat agt acc tgc ctg gat gac agc tgg att cac   96
Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His
             20                  25                  30
 
cct cga aac ctg acc ccc tcc tcc cca aag gac ctg cag atc cag ctg   144
Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu
         35                  40                  45
 
cac ttt gcc cac acc caa caa gga gac ctg ttc ccc gtg gct cac atc   192
His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile
     50                  55                  60
 
gaa tgg aca ctg cag aca gac gcc agc atc ctg tac ctc gag ggt gca   240
Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala
 65                  70                  75                  80
 
gag tta tct gtc ctg cag ctg aac acc aat gaa cgt ttg tgc gtc agg   288
Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg
                 85                  90                  95
 
ttt gag ttt ctg tcc aaa ctg agg cat cac cac agg cgg tgg cgt ttt   336
Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe
            100                 105                 110
 
acc ttc agc cac ttt gtg gtt gac cct gac cag gaa tat gag gtg acc   384
Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr
        115                 120                 125
 
gtt cac cac ctg ccc aag ccc atc cct gat ggg gac cca aac cac cag   432
Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln
    130                 135                 140
 
tcc aag aat ttc ctt gtg cct gac tgt gag cac gcc agg atg aag gta   480
Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val
145                 150                 155                 160
 
acc acg cca tgc atg agc tca gcc ctg ccc tgg ctc aac gtg tca gca   528
Thr Thr Pro Cys Met Ser Ser Ala Leu Pro Trp Leu Asn Val Ser Ala
                165                 170                 175
 
gat ggt gac aac gtg cat ctg gtt ctg aat gtc tct gag gag cag cac   576
Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His
            180                 185                 190
 
ttc ggc ctc tcc ctg tac tgg aat cag gtc cag ggc ccc cca aaa ccc   624
Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro
        195                 200                 205
 
cgg tgg cac aaa aac ctg act gga ccg cag atc att acc ttg aac cac   672
Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His
    210                 215                 220
 
aca gac ctg gtt ccc tgc ctc tgt att cag gtg tgg cct ctg gaa cct   720
Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro
225                 230                 235                 240
 
gac tcc gtt agg acg aac atc tgc ccc ttc agg gag gac ccc cgc gca   768
Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala
                245                 250                 255
 
cac cag aac ctc tgg caa gcc gcc cga ctg cga ctg ctg acc ctg cag   816
His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln
            260                 265                 270
 
agc tgg ctg ctg gac gca ccg tgc tcg ctg ccc gca gaa gcg gca ctg   864
Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu
        275                 280                 285
 
tgc tgg cgg gct ccg ggt ggg gac ccc tgc cag cca ctg gtc cca ccg   912
Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro
    290                 295                 300
 
ctt tcc tgg gag aac gtc act gtg gac aag gtt ctc gag ttc cca ttg   960
Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu
305                 310                 315                 320
 
ctg aaa ggc cac cct aac ctc tgt gtt cag gtg aac agc tcg gag aag   1008
Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys
                325                 330                 335
 
ctg cag ctg cag gag tgc ttg tgg gct gac tcc ctg ggg cct ctc aaa   1056
Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys
            340                 345                 350
 
gac gat gtg cta ctg ttg gag aca cga ggc ccc cag gac aac aga tcc   1104
Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser
        355                 360                 365
 
ctc tgt gcc ttg gaa ccc agt ggc tgt act tca cta ccc agc aaa gcc   1152
Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala
    370                 375                 380
 
tcc acg agg gca gct cgc ctt gga gag tac tta cta caa gac ctg cag   1200
Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln
385                 390                 395                 400
 
tca ggc cag tgt ctg cag cta tgg gac gat gac ttg gga gcg cta tgg   1248
Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp
                405                 410                 415
 
gcc tgc ccc atg gac aaa tac atc cac aag gag ccc aaa tct tca gac   1296
Ala Cys Pro Met Asp Lys Tyr Ile His Lys Glu Pro Lys Ser Ser Asp
            420                 425                 430
 
aaa act cac aca tgc cca ccg tgc cca gca cct gaa gcc gag ggg gca   1344
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala
        435                 440                 445
 
ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc   1392
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
    450                 455                 460
 
tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa   1440
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
465                 470                 475                 480
 
gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat   1488
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                485                 490                 495
 
aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt   1536
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
            500                 505                 510
 
gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag   1584
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
        515                 520                 525
 
gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca tcc tcc atc gag   1632
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu
    530                 535                 540
 
aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac   1680
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
545                 550                 555                 560
 
acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc agc ctg   1728
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
                565                 570                 575
 
acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg   1776
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
            580                 585                 590
 
gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg   1824
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
        595                 600                 605
 
ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac   1872
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
    610                 615                 620
 
aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat   1920
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
625                 630                 635                 640
 
gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg   1968
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                645                 650                 655
 
ggt aaa                                                           1974
Gly Lys

 

<210> 183
<211> 658
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exons 1-6 of IL-17RA with an N-terminal Serine
      deletion, exons 8-16 of IL-17RC and Fc5

<400> 183
Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu
 1               5                  10                  15      
Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His
            20                  25                  30          
Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu
        35                  40                  45              
His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile
    50                  55                  60                  
Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala
65                  70                  75                  80  
Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg
                85                  90                  95      
Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe
            100                 105                 110         
Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr
        115                 120                 125             
Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln
    130                 135                 140                 
Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val
145                 150                 155                 160 
Thr Thr Pro Cys Met Ser Ser Ala Leu Pro Trp Leu Asn Val Ser Ala
                165                 170                 175     
Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His
            180                 185                 190         
Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro
        195                 200                 205             
Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His
    210                 215                 220                 
Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro
225                 230                 235                 240 
Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala
                245                 250                 255     
His Gln Asn Leu Trp Gln Ala Ala Arg Leu Arg Leu Leu Thr Leu Gln
            260                 265                 270         
Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu
        275                 280                 285             
Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro
    290                 295                 300                 
Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu
305                 310                 315                 320 
Leu Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys
                325                 330                 335     
Leu Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys
            340                 345                 350         
Asp Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser
        355                 360                 365             
Leu Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala
    370                 375                 380                 
Ser Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln
385                 390                 395                 400 
Ser Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp
                405                 410                 415     
Ala Cys Pro Met Asp Lys Tyr Ile His Lys Glu Pro Lys Ser Ser Asp
            420                 425                 430         
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala
        435                 440                 445             
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
    450                 455                 460                 
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
465                 470                 475                 480 
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                485                 490                 495     
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
            500                 505                 510         
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
        515                 520                 525             
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu
    530                 535                 540                 
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
545                 550                 555                 560 
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
                565                 570                 575     
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
            580                 585                 590         
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
        595                 600                 605             
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
    610                 615                 620                 
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
625                 630                 635                 640 
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                645                 650                 655     
Gly Lys
        


<210> 184
<211> 96
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (1)...(96)

<400> 184
atg ggg gcc gca cgc agc ccg ccg tcc gct gtc ccg ggg ccc ctg ctg   48
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu
 1               5                   10                  15
 
ggg ctg ctc ctg ctg ctc ctg ggc gtg ctg gcc ccg ggt ggc gcc tcc   96
Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser
             20                  25                  30
 


<210> 185
<211> 32
<212> PRT
<213> Homo sapiens

<400> 185
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu
 1               5                  10                  15      
Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser
            20                  25                  30          


<210> 186
<211> 492
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL17A CH6 coding sequence

<400> 186
atgactcctg ggaagacctc attggtgtca ctgctactgc tgctgagcct ggaggccata 60
gtgaaggcag gaatcacaat cccacgaaat ccaggatgcc caaattctga ggacaagaac 120
ttcccccgga ctgtgatggt caacctgaac atccataacc ggaataccaa taccaatccc 180
aaaaggtcct cagattacta caaccgatcc acctcacctt ggaatctcca ccgcaatgag 240
gaccctgaga gatatccctc tgtgatctgg gaggcaaagt gccgccactt gggctgcatc 300
aacgctgatg ggaacgtgga ctaccacatg aactctgtcc ccatccagca agagatcctg 360
gtcctgcgca gggagcctcc acactgcccc aactccttcc ggctggagaa gatactggtg 420
tccgtgggct gcacctgtgt caccccgatt gtccaccatg tggcctccgg acaccatcac 480
catcatcatt aa                                                     492

<210> 187
<211> 163
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL17A-CH6

<400> 187
Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser
 1               5                  10                  15      
Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly
            20                  25                  30          
Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn
        35                  40                  45              
Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser
    50                  55                  60                  
Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu
65                  70                  75                  80  
Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His
                85                  90                  95      
Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser
            100                 105                 110         
Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His
        115                 120                 125             
Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys
    130                 135                 140                 
Thr Cys Val Thr Pro Ile Val His His Val Ala Ser Gly His His His
145                 150                 155                 160 
His His His
            


<210> 188
<211> 519
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL17F-CEE coding sequence

<400> 188
atgacagtga agaccctgca tggcccagcc atggtcaagt acttgctgct gtcgatattg 60
gggcttgcct ttctgagtga ggcggcagct cggaaaatcc ccaaagtagg acatactttt 120
ttccaaaagc ctgagagttg cccgcctgtg ccaggaggta gtatgaagct tgacattggc 180
atcatcaatg aaaaccagcg cgtttccatg tcacgtaaca tcgagagccg ctccacctcc 240
ccctggaatt acactgtcac ttgggacccc aaccggtacc cctcggaagt tgtacaggcc 300
cagtgtagga acttgggctg catcaatgct caaggaaagg aagacatctc catgaattcc 360
gttcccatcc agcaagagac cctggtcgtc cggaggaagc accaaggctg ctctgtttct 420
ttccagttgg agaaggtgct ggtgactgtt ggctgcacct gcgtcacccc tgtcatccac 480
catgtgcagt ccggagaaga atatatgccc atggaataa                        519

<210> 189
<211> 172
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL17F-CEE

<400> 189
Met Thr Val Lys Thr Leu His Gly Pro Ala Met Val Lys Tyr Leu Leu
 1               5                  10                  15      
Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser Glu Ala Ala Ala Arg Lys
            20                  25                  30          
Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro
        35                  40                  45              
Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu
    50                  55                  60                  
Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser
65                  70                  75                  80  
Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu
                85                  90                  95      
Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly
            100                 105                 110         
Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu
        115                 120                 125             
Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu
    130                 135                 140                 
Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His
145                 150                 155                 160 
His Val Gln Ser Gly Glu Glu Tyr Met Pro Met Glu
                165                 170         


<210> 190
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> EE tag

<400> 190
Glu Glu Tyr Met Pro Met Glu
 1               5          

