                         SEQUENCE LISTING

<110>  GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED 
       BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE
       Weinberger, Daniel R
       Huffaker, Stephen J.
       Kleinman, Joel E.
       Lu, Bai
 
<120>  SCHIZOPHRENIA-RELATED ISOFORM OF KCNH1 AND DEVELOPMENT OF 
       ANTIPSYCHOTIC DRUGS

<130>  NIH349.001VPC

<140>  Unknown
<141>  2008-02-28

<150>  US 60/920,220
<151>  2007-03-26

<160>  26    

<170>  PatentIn version 3.3

<210>  1
<211>  3897
<212>  DNA
<213>  Homo sapiens

<400>  1
ccatgggctc aggatgccgg tgcggagggg ccacgtcgcg ccgcagaaca ccttcctgga     60

caccatcatc cgcaagtttg agggccagag ccgtaagttc atcatcgcca acgctcgggt    120

ggagaactgc gccgtcatct actgcaacga cggcttctgc gagctgtgcg gctactcgcg    180

ggccgaggtg atgcagcgac cctgcacctg cgacttcctg cacgggccgc gcacgcagcg    240

ccgcgctgcc gcgcagatcg cgcaggcact gctgggcgcc gaggagcgca aagtggaaat    300

cgccttctac cggaaagatg ggagctgctt cctatgtctg gtggatgtgg tgcccgtgaa    360

gaacgaggat ggggctgtca tcatgttcat cctcaatttc gaggtggtga tggagaagga    420

catggtgggg tccccggctc atgacaccaa ccaccggggc ccccccacca gctggctggc    480

cccaggccgc gccaagacct tccgcctgaa gctgcccgcg ctgctggcgc tgacggcccg    540

ggagtcgtcg gtgcggtcgg gcggcgcggg cggcgcgggc gccccggggg ccgtggtggt    600

ggacgtggac ctgacgcccg cggcacccag cagcgagtcg ctggccctgg acgaagtgac    660

agccatggac aaccacgtgg cagggctcgg gcccgcggag gagcggcgtg cgctggtggg    720

tcccggctct ccgccccgca gcgcgcccgg ccagctccca tcgccccggg cgcacagcct    780

caaccccgac gcctcgggct ccagctgcag cctggcccgg acgcgctccc gagaaagctg    840

cgccagcgtg cgccgcgcct cgtcggccga cgacatcgag gccatgcgcg ccggggtgct    900

gcccccgcca ccgcgccacg ccagcaccgg ggccatgcac ccactgcgca gcggcttgct    960

caactccacc tcggactccg acctcgtgcg ctaccgcacc attagcaaga ttccccaaat   1020

caccctcaac tttgtggacc tcaagggcga ccccttcttg gcttcgccca ccagtgaccg   1080

tgagatcata gcacctaaga taaaggagcg aacccacaat gtcactgaga aggtcaccca   1140

ggtcctgtcc ctgggcgccg acgtgctgcc tgagtacaag ctgcaggcac cgcgcatcca   1200

ccgctggacc atcctgcatt acagcccctt caaggccgtg tgggactggc tcatcctgct   1260

gctggtcatc tacacggctg tcttcacacc ctactcggct gccttcctgc tgaaggagac   1320

ggaagaaggc ccgcctgcta ccgagtgtgg ctacgcctgc cagccgctgg ctgtggtgga   1380

cctcatcgtg gacatcatgt tcattgtgga catcctcatc aacttccgca ccacctacgt   1440

caatgccaac gaggaggtgg tcagccaccc cggccgcatc gccgtccact acttcaaggg   1500

ctggttcctc atcgacatgg tggccgccat ccccttcgac ctgctcatct tcggctctgg   1560

ctctgaggag ctgatcgggc tgctgaagac tgcgcggctg ctgcggctgg tgcgcgtggc   1620

gcggaagctg gatcgctact cagagtacgg cgcggccgtg ctgttcttgc tcatgtgcac   1680

ctttgcgctc atcgcgcact ggctagcctg catctggtac gccatcggca acatggagca   1740

gccacacatg gactcacgca tcggctggct gcacaacctg ggcgaccaga taggcaaacc   1800

ctacaacagc agcggcctgg gcggcccctc catcaaggac aagtatgtga cggcgctcta   1860

cttcaccttc agcagcctca ccagtgtggg cttcggcaac gtctctccca acaccaactc   1920

agagaagatc ttctccatct gcgtcatgct cattggctcc ctcatgtatg ctagcatctt   1980

cggcaacgtg tcggccatca tccagcggct gtactcgggc acagcccgct accacacaca   2040

gatgctgcgg gtgcgggagt tcatccgctt ccaccagatc cccaatcccc tgcgccagcg   2100

cctcgaggag tacttccagc acgcctggtc ctacaccaac ggcatcgaca tgaacgcggt   2160

gctgaagggc ttccctgagt gcctgcaggc tgacatctgc ctgcacctga accgctcact   2220

gctgcagcac tgcaaaccct tccgaggggc caccaagggc tgccttcggg ccctggccat   2280

gaagttcaag accacacatg caccgccagg ggacacactg gtgcatgctg gggacctgct   2340

caccgccctg tacttcatct cccggggctc catcgagatc ctgcggggcg acgtcgtcgt   2400

ggccatcctg gggaagaatg acatctttgg ggagcctctg aacctgtatg caaggcctgg   2460

caagtcgaac ggggatgtgc gggccctcac ctactgtgac ctacacaaga tccatcggga   2520

cgacctgctg gaggtgctgg acatgtaccc tgagttctcc gaccacttct ggtccagcct   2580

ggagatcacc ttcaacctgc gagataccaa catgatcccg ggctcccccg gcagtacgga   2640

gttagagggt ggcttcagtc ggcaacgcaa gcgcaagttg tccttccgca ggcgcacgga   2700

caaggacacg gagcagccag gggaggtgtc ggccttgggg ccgggccggg cgggggcagg   2760

gccgagtagc cggggccggc cgggggggcc gtggggggag agcccgtcca gtggcccctc   2820

cagccctgag agcagtgagg atgagggccc aggccgcagc tccagccccc tccgcctggt   2880

gcccttctcc agccccaggc cccccggaga gccgccgggt ggggagcccc tgatggagga   2940

ctgcgagaag agcagcgaca cttgcaaccc cctgtcaggc gccttctcag gagtgtccaa   3000

cattttcagc ttctgggggg acagtcgggg ccgccagtac caggagctcc ctcgatgccc   3060

cgcccccacc cccagcctcc tcaacatccc cctctccagc ccgggtcggc ggccccgggg   3120

cgacgtggag agcaggctgg atgccctcca gcgccagctc aacaggctgg agacccggct   3180

gagtgcagac atggccactg tcctgcagct gctacagagg cagatgacgc tggtcccgcc   3240

cgcctacagt gctgtgacca ccccggggcc tggccccact tccacatccc cgctgttgcc   3300

cgtcagcccc ctccccaccc tcaccttgga ctcgctttct caggtttccc agttcatggc   3360

gtgtgaggag ctgcccccgg gggccccaga gcttccccaa gaaggcccca cacgacgcct   3420

ctccctaccg ggccagctgg gggccctcac ctcccagccc ctgcacagac acggctcgga   3480

cccgggcagt tagtggggct gcccagtgtg gacacgtggc tcacccaggg atcaaggcgc   3540

tgctgggccg ctccccttgg aggccctgct caggaggccc tgaccgtgga aggggagagg   3600

aactcgaaag cacagctcct cccccagccc ttgggaccat cttctcctgc agtcccctgg   3660

gccccagtga gaggggcagg ggcagggccg gcagtaggtg gggcctgtgg tccccccact   3720

gccctgaggg cattagctgg tctaactgcc cggaggcacc cggccctggg ccttaggcac   3780

ctcaaggact tttctgctat ttactgctct tattgttaag gataataatt aaggatcata   3840

tgaataatta atgaagatgc tgatgactat gaataataaa taattatcct gaggaga      3897


<210>  2
<211>  1159
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
    130                 135                 140                 


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
145                 150                 155                 160 


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
                165                 170                 175     


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
            180                 185                 190         


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
        195                 200                 205             


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
    210                 215                 220                 


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
225                 230                 235                 240 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
                245                 250                 255     


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
            260                 265                 270         


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
        275                 280                 285             


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
    290                 295                 300                 


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
305                 310                 315                 320 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
                325                 330                 335     


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
            340                 345                 350         


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
        435                 440                 445             


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
    450                 455                 460                 


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
465                 470                 475                 480 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
                485                 490                 495     


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
            500                 505                 510         


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
        515                 520                 525             


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
    530                 535                 540                 


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
545                 550                 555                 560 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
                565                 570                 575     


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
            580                 585                 590         


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
        595                 600                 605             


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
    610                 615                 620                 


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
625                 630                 635                 640 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
                645                 650                 655     


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
            660                 665                 670         


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
        675                 680                 685             


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
    690                 695                 700                 


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
705                 710                 715                 720 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
                725                 730                 735     


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
            740                 745                 750         


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
        755                 760                 765             


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
    770                 775                 780                 


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
785                 790                 795                 800 


Lys Asn Asp Ile Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly 
                805                 810                 815     


Lys Ser Asn Gly Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys 
            820                 825                 830         


Ile His Arg Asp Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe 
        835                 840                 845             


Ser Asp His Phe Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp 
    850                 855                 860                 


Thr Asn Met Ile Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly 
865                 870                 875                 880 


Phe Ser Arg Gln Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp 
                885                 890                 895     


Lys Asp Thr Glu Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg 
            900                 905                 910         


Ala Gly Ala Gly Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly 
        915                 920                 925             


Glu Ser Pro Ser Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu 
    930                 935                 940                 


Gly Pro Gly Arg Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser 
945                 950                 955                 960 


Pro Arg Pro Pro Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp 
                965                 970                 975     


Cys Glu Lys Ser Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser 
            980                 985                 990         


Gly Val Ser Asn Ile Phe Ser Phe  Trp Gly Asp Ser Arg  Gly Arg Gln 
        995                 1000                 1005             


Tyr Gln  Glu Leu Pro Arg Cys  Pro Ala Pro Thr Pro  Ser Leu Leu 
    1010                 1015                 1020             


Asn Ile  Pro Leu Ser Ser Pro  Gly Arg Arg Pro Arg  Gly Asp Val 
    1025                 1030                 1035             


Glu Ser  Arg Leu Asp Ala Leu  Gln Arg Gln Leu Asn  Arg Leu Glu 
    1040                 1045                 1050             


Thr Arg  Leu Ser Ala Asp Met  Ala Thr Val Leu Gln  Leu Leu Gln 
    1055                 1060                 1065             


Arg Gln  Met Thr Leu Val Pro  Pro Ala Tyr Ser Ala  Val Thr Thr 
    1070                 1075                 1080             


Pro Gly  Pro Gly Pro Thr Ser  Thr Ser Pro Leu Leu  Pro Val Ser 
    1085                 1090                 1095             


Pro Leu  Pro Thr Leu Thr Leu  Asp Ser Leu Ser Gln  Val Ser Gln 
    1100                 1105                 1110             


Phe Met  Ala Cys Glu Glu Leu  Pro Pro Gly Ala Pro  Glu Leu Pro 
    1115                 1120                 1125             


Gln Glu  Gly Pro Thr Arg Arg  Leu Ser Leu Pro Gly  Gln Leu Gly 
    1130                 1135                 1140             


Ala Leu  Thr Ser Gln Pro Leu  His Arg His Gly Ser  Asp Pro Gly 
    1145                 1150                 1155             


Ser 
    


<210>  3
<211>  4717
<212>  DNA
<213>  Homo sapiens

<400>  3
ggggcggggg gcggtggggc agcagggggc ccatgtgctc aacagggagc tgagggagac     60

caggggtgct tggcttaggg gactgacctc atctggtaca gggcctttgg tggacagaga    120

gagactggaa aagaaaaagt caaggatcga ggggaacgcg aggcgaggtg aagatgaaag    180

atctagaagc agtgcttctt agactctttg gtgaaggatc agtgtttttt aatgctaata    240

tgttataggc tggtacatct gtgaaataca agagcacatg cgtggatttt gtggtgatgc    300

caaattgctg taaagttttt gaaattcttg ctctcaacgt ctgtccttat cttgtgtgct    360

gacacaacgg ctggtgctaa tctagagaga acagagagac agatagtaac agctaaccgt    420

ctgtagtgtg cggcatacgc caggcattgc ctaagcgctc agcatgtgct gacttggtta    480

atctttataa ctcatgagaa aagaattata tacattatgt gtatcacaac atcactgtgt    540

accccataaa tatgtacaat tattgtgtca attaaaaagt taaaaaattt taaaaagaaa    600

aaattattat tcttcccatt ttatagatgg aaaaaatgag gcacaaggat gttaaataat    660

ttaggaaaaa agcataagtg attaagcagc agatccgggc tatgaaccca gagatcgtag    720

gcctaaagtc tgtgggctta agcactgtgc tacagcgcct cgcttgaggg aaaggcagag    780

gtgctgggag gatatgagga aatgagatag ggaggaaatg agatcaaaga tggcagaaga    840

aaggatcata gccagcgtga gaaaaagtgc agccgggaaa gagctagata aatcatatag    900

gcagagagag gggtagggga gcctggcagc aacaagctgg ggtagacaga ttgaggggag    960

ccataagggc ggcaggcaca tggccgggtg ggggatcagg acgggagatc ccggagagga   1020

agggccatac ggggaggcag aagtggacgg gcccacttgg gttccagggt ccatcctgcg   1080

tggctttctg ctctgcccac tgagtgggtg ccaagggggc tatgtcctcc cactctgcag   1140

ggagctgctt cctatgtctg gtggatgtgg tgcccgtgaa gaacgaggat ggggctgtca   1200

tcatgttcat cctcaatttc gaggtggtga tggagaagga catggtgggg tccccggctc   1260

atgacaccaa ccaccggggc ccccccacca gctggctggc cccaggccgc gccaagacct   1320

tccgcctgaa gctgcccgcg ctgctggcgc tgacggcccg ggagtcgtcg gtgcggtcgg   1380

gcggcgcggg cggcgcgggc gccccggggg ccgtggtggt ggacgtggac ctgacgcccg   1440

cggcacccag cagcgagtcg ctggccctgg acgaagtgac agccatggac aaccacgtgg   1500

cagggctcgg gcccgcggag gagcggcgtg cgctggtggg tcccggctct ccgccccgca   1560

gcgcgcccgg ccagctccca tcgccccggg cgcacagcct caaccccgac gcctcgggct   1620

ccagctgcag cctggcccgg acgcgctccc gagaaagctg cgccagcgtg cgccgcgcct   1680

cgtcggccga cgacatcgag gccatgcgcg ccggggtgct gcccccgcca ccgcgccacg   1740

ccagcaccgg ggccatgcac ccactgcgca gcggcttgct caactccacc tcggactccg   1800

acctcgtgcg ctaccgcacc attagcaaga ttccccaaat caccctcaac tttgtggacc   1860

tcaagggcga ccccttcttg gcttcgccca ccagtgaccg tgagatcata gcacctaaga   1920

taaaggagcg aacccacaat gtcactgaga aggtcaccca ggtcctgtcc ctgggcgccg   1980

acgtgctgcc tgagtacaag ctgcaggcac cgcgcatcca ccgctggacc atcctgcatt   2040

acagcccctt caaggccgtg tgggactggc tcatcctgct gctggtcatc tacacggctg   2100

tcttcacacc ctactcggct gccttcctgc tgaaggagac ggaagaaggc ccgcctgcta   2160

ccgagtgtgg ctacgcctgc cagccgctgg ctgtggtgga cctcatcgtg gacatcatgt   2220

tcattgtgga catcctcatc aacttccgca ccacctacgt caatgccaac gaggaggtgg   2280

tcagccaccc cggccgcatc gccgtccact acttcaaggg ctggttcctc atcgacatgg   2340

tggccgccat ccccttcgac ctgctcatct tcggctctgg ctctgaggag ctgatcgggc   2400

tgctgaagac tgcgcggctg ctgcggctgg tgcgcgtggc gcggaagctg gatcgctact   2460

cagagtacgg cgcggccgtg ctgttcttgc tcatgtgcac ctttgcgctc atcgcgcact   2520

ggctagcctg catctggtac gccatcggca acatggagca gccacacatg gactcacgca   2580

tcggctggct gcacaacctg ggcgaccaga taggcaaacc ctacaacagc agcggcctgg   2640

gcggcccctc catcaaggac aagtatgtga cggcgctcta cttcaccttc agcagcctca   2700

ccagtgtggg cttcggcaac gtctctccca acaccaactc agagaagatc ttctccatct   2760

gcgtcatgct cattggctcc ctcatgtatg ctagcatctt cggcaacgtg tcggccatca   2820

tccagcggct gtactcgggc acagcccgct accacacaca gatgctgcgg gtgcgggagt   2880

tcatccgctt ccaccagatc cccaatcccc tgcgccagcg cctcgaggag tacttccagc   2940

acgcctggtc ctacaccaac ggcatcgaca tgaacgcggt gctgaagggc ttccctgagt   3000

gcctgcaggc tgacatctgc ctgcacctga accgctcact gctgcagcac tgcaaaccct   3060

tccgaggggc caccaagggc tgccttcggg ccctggccat gaagttcaag accacacatg   3120

caccgccagg ggacacactg gtgcatgctg gggacctgct caccgccctg tacttcatct   3180

cccggggctc catcgagatc ctgcggggcg acgtcgtcgt ggccatcctg gggaagaatg   3240

acatctttgg ggagcctctg aacctgtatg caaggcctgg caagtcgaac ggggatgtgc   3300

gggccctcac ctactgtgac ctacacaaga tccatcggga cgacctgctg gaggtgctgg   3360

acatgtaccc tgagttctcc gaccacttct ggtccagcct ggagatcacc ttcaacctgc   3420

gagataccaa catgatcccg ggctcccccg gcagtacgga gttagagggt ggcttcagtc   3480

ggcaacgcaa gcgcaagttg tccttccgca ggcgcacgga caaggacacg gagcagccag   3540

gggaggtgtc ggccttgggg ccgggccggg cgggggcagg gccgagtagc cggggccggc   3600

cgggggggcc gtggggggag agcccgtcca gtggcccctc cagccctgag agcagtgagg   3660

atgagggccc aggccgcagc tccagccccc tccgcctggt gcccttctcc agccccaggc   3720

cccccggaga gccgccgggt ggggagcccc tgatggagga ctgcgagaag agcagcgaca   3780

cttgcaaccc cctgtcaggc gccttctcag gagtgtccaa cattttcagc ttctgggggg   3840

acagtcgggg ccgccagtac caggagctcc ctcgatgccc cgcccccacc cccagcctcc   3900

tcaacatccc cctctccagc ccgggtcggc ggccccgggg cgacgtggag agcaggctgg   3960

atgccctcca gcgccagctc aacaggctgg agacccggct gagtgcagac atggccactg   4020

tcctgcagct gctacagagg cagatgacgc tggtcccgcc cgcctacagt gctgtgacca   4080

ccccggggcc tggccccact tccacatccc cgctgttgcc cgtcagcccc ctccccaccc   4140

tcaccttgga ctcgctttct caggtttccc agttcatggc gtgtgaggag ctgcccccgg   4200

gggccccaga gcttccccaa gaaggcccca cacgacgcct ctccctaccg ggccagctgg   4260

gggccctcac ctcccagccc ctgcacagac acggctcgga cccgggcagt tagtggggct   4320

gcccagtgtg gacacgtggc tcacccaggg atcaaggcgc tgctgggccg ctccccttgg   4380

aggccctgct caggaggccc tgaccgtgga aggggagagg aactcgaaag cacagctcct   4440

cccccagccc ttgggaccat cttctcctgc agtcccctgg gccccagtga gaggggcagg   4500

ggcagggccg gcagtaggtg gggcctgtgg tccccccact gccctgaggg cattagctgg   4560

tctaactgcc cggaggcacc cggccctggg ccttaggcac ctcaaggact tttctgctat   4620

ttactgctct tattgttaag gataataatt aaggatcata tgaataatta atgaagatgc   4680

tgatgactat gaataataaa taattatcct gaggaga                            4717


<210>  4
<211>  1063
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ser His Ser Ala Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
1               5                   10                  15      


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
            20                  25                  30          


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
        35                  40                  45              


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
    50                  55                  60                  


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
65                  70                  75                  80  


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
                85                  90                  95      


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
            100                 105                 110         


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
        115                 120                 125             


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
    130                 135                 140                 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
145                 150                 155                 160 


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
                165                 170                 175     


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
            180                 185                 190         


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
        195                 200                 205             


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
    210                 215                 220                 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
225                 230                 235                 240 


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
                245                 250                 255     


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
            260                 265                 270         


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
        275                 280                 285             


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
    290                 295                 300                 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
305                 310                 315                 320 


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
                325                 330                 335     


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
            340                 345                 350         


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
        355                 360                 365             


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
    370                 375                 380                 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
385                 390                 395                 400 


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
                405                 410                 415     


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
            420                 425                 430         


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
        435                 440                 445             


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
    450                 455                 460                 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
465                 470                 475                 480 


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
                485                 490                 495     


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
            500                 505                 510         


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
        515                 520                 525             


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
    530                 535                 540                 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
545                 550                 555                 560 


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
                565                 570                 575     


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
            580                 585                 590         


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
        595                 600                 605             


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
    610                 615                 620                 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
625                 630                 635                 640 


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
                645                 650                 655     


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
            660                 665                 670         


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
        675                 680                 685             


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
    690                 695                 700                 


Lys Asn Asp Ile Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly 
705                 710                 715                 720 


Lys Ser Asn Gly Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys 
                725                 730                 735     


Ile His Arg Asp Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe 
            740                 745                 750         


Ser Asp His Phe Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp 
        755                 760                 765             


Thr Asn Met Ile Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly 
    770                 775                 780                 


Phe Ser Arg Gln Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp 
785                 790                 795                 800 


Lys Asp Thr Glu Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg 
                805                 810                 815     


Ala Gly Ala Gly Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly 
            820                 825                 830         


Glu Ser Pro Ser Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu 
        835                 840                 845             


Gly Pro Gly Arg Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser 
    850                 855                 860                 


Pro Arg Pro Pro Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp 
865                 870                 875                 880 


Cys Glu Lys Ser Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser 
                885                 890                 895     


Gly Val Ser Asn Ile Phe Ser Phe Trp Gly Asp Ser Arg Gly Arg Gln 
            900                 905                 910         


Tyr Gln Glu Leu Pro Arg Cys Pro Ala Pro Thr Pro Ser Leu Leu Asn 
        915                 920                 925             


Ile Pro Leu Ser Ser Pro Gly Arg Arg Pro Arg Gly Asp Val Glu Ser 
    930                 935                 940                 


Arg Leu Asp Ala Leu Gln Arg Gln Leu Asn Arg Leu Glu Thr Arg Leu 
945                 950                 955                 960 


Ser Ala Asp Met Ala Thr Val Leu Gln Leu Leu Gln Arg Gln Met Thr 
                965                 970                 975     


Leu Val Pro Pro Ala Tyr Ser Ala Val Thr Thr Pro Gly Pro Gly Pro 
            980                 985                 990         


Thr Ser Thr Ser Pro Leu Leu Pro  Val Ser Pro Leu Pro  Thr Leu Thr 
        995                 1000                 1005             


Leu Asp  Ser Leu Ser Gln Val  Ser Gln Phe Met Ala  Cys Glu Glu 
    1010                 1015                 1020             


Leu Pro  Pro Gly Ala Pro Glu  Leu Pro Gln Glu Gly  Pro Thr Arg 
    1025                 1030                 1035             


Arg Leu  Ser Leu Pro Gly Gln  Leu Gly Ala Leu Thr  Ser Gln Pro 
    1040                 1045                 1050             


Leu His  Arg His Gly Ser Asp  Pro Gly Ser 
    1055                 1060             


<210>  5
<211>  1058
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Ser Cys Phe Leu Cys Leu Val Asp Val Val Pro Val Lys Asn 
1               5                   10                  15      


Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn Phe Glu Val Val Met 
            20                  25                  30          


Glu Lys Asp Met Val Gly Ser Pro Ala His Asp Thr Asn His Arg Gly 
        35                  40                  45              


Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala Lys Thr Phe Arg Leu 
    50                  55                  60                  


Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg Glu Ser Ser Val Arg 
65                  70                  75                  80  


Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly Ala Val Val Val Asp 
                85                  90                  95      


Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu Ser Leu Ala Leu Asp 
            100                 105                 110         


Glu Val Thr Ala Met Asp Asn His Val Ala Gly Leu Gly Pro Ala Glu 
        115                 120                 125             


Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro Pro Arg Ser Ala Pro 
    130                 135                 140                 


Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu Asn Pro Asp Ala Ser 
145                 150                 155                 160 


Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser Arg Glu Ser Cys Ala 
                165                 170                 175     


Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile Glu Ala Met Arg Ala 
            180                 185                 190         


Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser Thr Gly Ala Met His 
        195                 200                 205             


Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser Asp Ser Asp Leu Val 
    210                 215                 220                 


Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile Thr Leu Asn Phe Val 
225                 230                 235                 240 


Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro Thr Ser Asp Arg Glu 
                245                 250                 255     


Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His Asn Val Thr Glu Lys 
            260                 265                 270         


Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr Lys 
        275                 280                 285             


Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile Leu His Tyr Ser Pro 
    290                 295                 300                 


Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr Thr 
305                 310                 315                 320 


Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu Leu Lys Glu Thr Glu 
                325                 330                 335     


Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala Cys Gln Pro Leu Ala 
            340                 345                 350         


Val Val Asp Leu Ile Val Asp Ile Met Phe Ile Val Asp Ile Leu Ile 
        355                 360                 365             


Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu Glu Val Val Ser His 
    370                 375                 380                 


Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly Trp Phe Leu Ile Asp 
385                 390                 395                 400 


Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile Phe Gly Ser Gly Ser 
                405                 410                 415     


Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg Leu Leu Arg Leu Val 
            420                 425                 430         


Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu Tyr Gly Ala Ala Val 
        435                 440                 445             


Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile Ala His Trp Leu Ala 
    450                 455                 460                 


Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln Pro His Met Asp Ser 
465                 470                 475                 480 


Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln Ile Gly Lys Pro Tyr 
                485                 490                 495     


Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys Asp Lys Tyr Val Thr 
            500                 505                 510         


Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser Val Gly Phe Gly Asn 
        515                 520                 525             


Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe Ser Ile Cys Val Met 
    530                 535                 540                 


Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe Gly Asn Val Ser Ala 
545                 550                 555                 560 


Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg Tyr His Thr Gln Met 
                565                 570                 575     


Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln Ile Pro Asn Pro Leu 
            580                 585                 590         


Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala Trp Ser Tyr Thr Asn 
        595                 600                 605             


Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe Pro Glu Cys Leu Gln 
    610                 615                 620                 


Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu Leu Gln His Cys Lys 
625                 630                 635                 640 


Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg Ala Leu Ala Met Lys 
                645                 650                 655     


Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr Leu Val His Ala Gly 
            660                 665                 670         


Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg Gly Ser Ile Glu Ile 
        675                 680                 685             


Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly Lys Asn Asp Ile Phe 
    690                 695                 700                 


Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly Lys Ser Asn Gly Asp 
705                 710                 715                 720 


Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys Ile His Arg Asp Asp 
                725                 730                 735     


Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe Ser Asp His Phe Trp 
            740                 745                 750         


Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp Thr Asn Met Ile Pro 
        755                 760                 765             


Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly Phe Ser Arg Gln Arg 
    770                 775                 780                 


Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp Lys Asp Thr Glu Gln 
785                 790                 795                 800 


Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg Ala Gly Ala Gly Pro 
                805                 810                 815     


Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly Glu Ser Pro Ser Ser 
            820                 825                 830         


Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu Gly Pro Gly Arg Ser 
        835                 840                 845             


Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser Pro Arg Pro Pro Gly 
    850                 855                 860                 


Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp Cys Glu Lys Ser Ser 
865                 870                 875                 880 


Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser Gly Val Ser Asn Ile 
                885                 890                 895     


Phe Ser Phe Trp Gly Asp Ser Arg Gly Arg Gln Tyr Gln Glu Leu Pro 
            900                 905                 910         


Arg Cys Pro Ala Pro Thr Pro Ser Leu Leu Asn Ile Pro Leu Ser Ser 
        915                 920                 925             


Pro Gly Arg Arg Pro Arg Gly Asp Val Glu Ser Arg Leu Asp Ala Leu 
    930                 935                 940                 


Gln Arg Gln Leu Asn Arg Leu Glu Thr Arg Leu Ser Ala Asp Met Ala 
945                 950                 955                 960 


Thr Val Leu Gln Leu Leu Gln Arg Gln Met Thr Leu Val Pro Pro Ala 
                965                 970                 975     


Tyr Ser Ala Val Thr Thr Pro Gly Pro Gly Pro Thr Ser Thr Ser Pro 
            980                 985                 990         


Leu Leu Pro Val Ser Pro Leu Pro  Thr Leu Thr Leu Asp  Ser Leu Ser 
        995                 1000                 1005             


Gln Val  Ser Gln Phe Met Ala  Cys Glu Glu Leu Pro  Pro Gly Ala 
    1010                 1015                 1020             


Pro Glu  Leu Pro Gln Glu Gly  Pro Thr Arg Arg Leu  Ser Leu Pro 
    1025                 1030                 1035             


Gly Gln  Leu Gly Ala Leu Thr  Ser Gln Pro Leu His  Arg His Gly 
    1040                 1045                 1050             


Ser Asp  Pro Gly Ser 
    1055             


<210>  6
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys 
    130                 135 


<210>  7
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu His Val Ala Phe Gly Ser Glu Asp Ile Glu Asn Thr Leu Ala 
1               5                   10                  15      


Lys Met Asp Asp Gly Gln Leu Asp Gly Leu Ala Phe Gly Ala Ile Gln 
            20                  25                  30          


Leu Asp Gly Asp Gly Asn Ile Leu Gln Tyr Asn Ala Ala Glu Gly Asp 
        35                  40                  45              


Ile Thr Gly Arg Asp Pro Lys Gln Val Ile Gly Lys Asn Phe Phe Lys 
    50                  55                  60                  


Asp Val Ala Pro Cys Thr Asp Ser Pro Glu Phe Tyr Gly Lys Phe Lys 
65                  70                  75                  80  


Glu Gly Val Ala Ser Gly Asn Leu Asn Thr Met Phe Glu Tyr Thr Phe 
                85                  90                  95      


Asp Tyr Gln Met Thr Pro Thr Lys Val Lys Val His Met Lys Lys Ala 
            100                 105                 110         


Leu Ser Gly Asp Ser Tyr Trp Val Phe Val Lys Arg Val 
        115                 120                 125 


<210>  8
<211>  403
<212>  DNA
<213>  Homo sapiens

<400>  8
ggggagcctg gcagcaacaa gctggggtag acagattgag gggagccata agggcggcag     60

gcacatggcc gggtggggga tcaggacggg agatcccgga gaggaagggc catacgggga    120

ggcagaagtg gacgggccca cttgggttcc agggtccatc ctgcgtggct ttctgctctg    180

cccactgagt gggtgccaag ggggctatgt cctcccactc tgcagggagc tgcttcctat    240

gtctggtgga tgtggtgccc gtgaagaacg aggatggggc tgtcatcatg ttcatcctca    300

atttcgaggt ggtgatggag aaggacatgg tggggtcccc ggctcatgac accaaccacc    360

ggggcccccc caccagctgg ctggccccag gtaagtgtac ttg                      403


<210>  9
<211>  377
<212>  DNA
<213>  Rhesus

<400>  9
tagcaacaag ctggggcaga cagattgagg ggagccataa gggtggcagg cacatggccg     60

ggtgggggat caggatggga gatcctggag aggaagggcc atatggggag gcagaagtgg    120

aagggtccgc ttgggctcca ggctttctgc tctgcccact gagagggtgc caaggggact    180

atgttctccc actccacagg gagctgcttc ctatgtctgg tggatgtggt gcccgtgaag    240

aacgaggatg gggctgtcat catgttcatc ctcaatttcg aggtggtgat ggagaaggac    300

atggtggggt ccccggctca tgacaccaat caccggggcc cccccaccag ctggctggcc    360

tcaggtaagt gtacttg                                                   377


<210>  10
<211>  430
<212>  DNA
<213>  Mus musculus

<400>  10
caggagaaac agggaaagaa ggctgagaga tgagatgagc agtgagggag gaagtgtgga     60

ctggctggca gtctggcaca gccagctgca gggttagagc agggtcagga gttgcagatg    120

tgggctattg ggctgtggta gaggctgatg ggcccttttg ggtttagagg tccttcctgg    180

ccattttgtg tcatgcacac ttggggagga gaatctgggg tcaccatggc caatgccttt    240

cctactctgc agggagctgc ttcctgtgtc tggtggatgt ggtacccgtg aagaatgaag    300

atggggctgt gatcatgttc atcctcaact ttgaagtagt gatggagaag gacatggtag    360

ggtccccggc tcatgacacc aaccacaggg gcccctctac cagctggcta gcttctggta    420

agtgcagcca                                                           430


<210>  11
<211>  426
<212>  DNA
<213>  Rattus norvecicus

<400>  11
aggagaaact gggaaagaag gctgagggat gagatgggtg gtgagggagg aagtgtggac     60

tggctgcagt ctggcctagc caggtgcagg ggtcagagca gggctgggaa ttgtagatgt    120

gggctgttgg ggtgtggtag aagttgatgg gcccttctgg gttcagaggt ccttcctggt    180

cactttgtgt cctgcccact tggggagaag gatctggtgt caccatggcc catgcctttc    240

ccttgcaggg agctgcttcc tgtgtttggt ggatgtggtg cccgtgaaga atgaggatgg    300

ggctgtcatc atgtttatcc tcaactttga agtggtgatg gagaaggaca tggtagggtc    360

gccagctcat gacaccaatc acagggggcc ctctaccagc tggctagctt ctggtaagtg    420

cagtca                                                               426


<210>  12
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Ser His Ser Ala Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
1               5                   10                  15      


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
            20                  25                  30          


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
        35                  40                  45              


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Lys Cys 
    50                  55                  60                  


Thr 
65  


<210>  13
<211>  65
<212>  PRT
<213>  Rhesus

<400>  13

Met Phe Ser His Ser Thr Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
1               5                   10                  15      


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
            20                  25                  30          


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
        35                  40                  45              


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Ser Gly Lys Cys 
    50                  55                  60                  


Thr 
65  


<210>  14
<211>  84
<212>  PRT
<213>  Mus musculus

<400>  14

Leu Ala Ile Leu Cys His Ala His Leu Gly Arg Arg Ile Trp Gly His 
1               5                   10                  15      


His Gly Gln Cys Leu Ser Tyr Ser Ala Gly Ser Cys Phe Leu Cys Leu 
            20                  25                  30          


Val Asp Val Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe 
        35                  40                  45              


Ile Leu Asn Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro 
    50                  55                  60                  


Ala His Asp Thr Asn His Arg Gly Pro Ser Thr Ser Trp Leu Ala Ser 
65                  70                  75                  80  


Gly Lys Cys Ser 
                


<210>  15
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Leu Gly Ile Val Asp Val Gly Cys Trp Gly Val Val Glu Val Asp Gly 
1               5                   10                  15      


Pro Phe Trp Val Gln Arg Ser Phe Leu Val Thr Leu Cys Pro Ala His 
            20                  25                  30          


Leu Gly Arg Arg Ile Trp Cys His His Gly Pro Cys Leu Ser Leu Ala 
        35                  40                  45              


Gly Ser Cys Phe Leu Cys Leu Val Asp Val Val Pro Val Lys Asn Glu 
    50                  55                  60                  


Asp Gly Ala Val Ile Met Phe Ile Leu Asn Phe Glu Val Val Met Glu 
65                  70                  75                  80  


Lys Asp Met Val Gly Ser Pro Ala His Asp Thr Asn His Arg Gly Pro 
                85                  90                  95      


Ser Thr Ser Trp Leu Ala Ser Gly Lys Cys Ser 
            100                 105         


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal peptide

<400>  16

Met Ser Ser His Ala Ser 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  N-terminal peptide

<400>  17

Met Phe Ser His Ser Thr 
1               5       


<210>  18
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  18
catgagaaaa gaattatata cattatgtgt atcacaacat c                         41


<210>  19
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  19
gcctcatttt ttccatctat aaaatgggaa                                      30


<210>  20
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  20
actgtgtacc ccataaatat gta                                             23


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  21
tgtgggttcg ctcctttatc                                                 20


<210>  22
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  22
catggcctcg atgtcgtc                                                   18


<210>  23
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  23
atgatgacag ccccatcct                                                  19


<210>  24
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  24
catacgggga ggcagaagt                                                  19


<210>  25
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  25
catacgggga ggcagaagt                                                  19


<210>  26
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  26
cttcttgggg aagctctgg                                                  19


