                         SEQUENCE LISTING

<110>  Shu-Wha Lin, Chia-Ni Lin, Hua-Lin Wu, Guey-Yueh Shi
 
<120>  RECOMBINANT HUMAN FACTOR IX AND USE THEREOF

<130>  0675-Dr.Lin-PCT

<160>  29    

<170>  PatentIn version 3.4


<210>  1
<211>  415
<212>  PRT
<213>  Homo sapiens

<220>
<221>  Protein
<222>  (1)..(415)
<223>  IX-1
<400>  1

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  2
<211>  415
<212>  PRT
<213>  Homo sapiens

<220>
<221>  Protein
<222>  (1)..(415)
<223>  IX-2 
<400>  2

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Ala Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  3
<211>  415
<212>  PRT
<213>  Homo sapiens

<220>
<221>  Protein
<222>  (1)..(415)
<223>  IX-3
<400>  3

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Ala Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 

<210>  4
<211>  415
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Protein
<222>  (1)..(415)
<223>  IX-4
<400>  4

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Ala Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  5
<211>  415
<212>  PRT
<213>  Homo sapiens

<220>
<221>  Protein
<222>  (1)..(415)
<223>  IX-5
<400>  5

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Ala Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Ala Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  6
<211>  415
<212>  PRT
<213>  Homo sapiens

<220>
<221>  Protein
<222>  (1)..(415)
<223>  IX-6
<400>  6

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Ala Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Ala Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  7
<211>  415
<212>  PRT
<213>  Homo sapiens

<220>
<221>  Protein
<222>  (1)..(415)
<223>  IX-7
<400>  7

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  8
<211>  415
<212>  PRT
<213>  Homo sapiens

<220>
<221>  Protein
<222>  (1)..(415)
<223>  IX-8
<400>  8

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Ala Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  9
<211>  2775
<212>  DNA
<213>  Homo sapiens

<220>
<221>  DNA
<222>  (1)..(2775)
<223>  IX-1
<400>  9
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta     60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt    120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt    180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac    240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat    300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc    360

tttggatttg aaggaaagaa ctgtgaatta gatgcaacat gtaacattaa gaatggcaga    420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga    480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga    540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac    600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca    660

tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg    720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa    780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt    840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt    900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa    960

ctggacgaac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa   1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc   1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc   1140

acatgtcttc gatctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat   1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa   1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa   1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc   1380

acttaatgaa agatggattt ccaaggttaa ttcattggaa ttgaaaatta acagggcctc   1440

tcactaacta atcactttcc catcttttgt tagatttgaa tatatacatt ctatgatcat   1500

tgctttttct ctttacaggg gagaatttca tattttacct gagcaaattg attagaaaat   1560

ggaaccacta gaggaatata atgtgttagg aaattacagt catttctaag ggcccagccc   1620

ttgacaaaat tgtgaagtta aattctccac tctgtccatc agatactatg gttctccact   1680

atggcaacta actcactcaa ttttccctcc ttagcagcat tccatcttcc cgatcttctt   1740

tgcttctcca accaaaacat caatgtttat tagttctgta tacagtacag gatctttggt   1800

ctactctatc acaaggccag taccacactc atgaagaaag aacacaggag tagctgagag   1860

gctaaaactc atcaaaaaca ctactccttt tcctctaccc tattcctcaa tcttttacct   1920

tttccaaatc ccaatcccca aatcagtttt tctctttctt actccctctc tcccttttac   1980

cctccatggt cgttaaagga gagatgggga gcatcattct gttatacttc tgtacacagt   2040

tatacatgtc tatcaaaccc agacttgctt ccatagtgga gacttgcttt tcagaacata   2100

gggatgaagt aaggtgcctg aaaagtttgg gggaaaagtt tctttcagag agttaagtta   2160

ttttatatat ataatatata tataaaatat ataatataca atataaatat atagtgtgtg   2220

tgtgtatgcg tgtgtgtaga cacacacgca tacacacata taatggaagc aataagccat   2280

tctaagagct tgtatggtta tggaggtctg actaggcatg atttcacgaa ggcaagattg   2340

gcatatcatt gtaactaaaa aagctgacat tgacccagac atattgtact ctttctaaaa   2400

ataataataa taatgctaac agaaagaaga gaaccgttcg tttgcaatct acagctagta   2460

gagactttga ggaagaattc aacagtgtgt cttcagcagt gttcagagcc aagcaagaag   2520

ttgaagttgc ctagaccaga ggacataagt atcatgtctc ctttaactag cataccccga   2580

agtggagaag ggtgcagcag gctcaaaggc ataagtcatt ccaatcagcc aactaagttg   2640

tccttttctg gtttcgtgtt caccatggaa cattttgatt atagttaatc cttctatctt   2700

gaatcttcta gagagttgct gaccaactga cgtatgtttc cctttgtgaa ttaataaact   2760

ggtgttctgg ttcat                                                    2775


<210>  10
<211>  2775
<212>  DNA
<213>  Homo sapiens


<220>
<221>  DNA
<222>  (1)..(2775)
<223>  IX-2
<400>  10
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta     60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt    120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt    180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac    240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat    300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc    360

tttggatttg aaggaaagaa ctgtgaatta gatgtaacat gtaacattaa gaatggcaga    420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga    480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga    540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac    600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca    660

tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg    720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa    780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt    840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt    900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa    960

ctggacgcac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa   1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc   1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc   1140

acatgtcttc gatctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat   1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa   1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa   1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc   1380

acttaatgaa agatggattt ccaaggttaa ttcattggaa ttgaaaatta acagggcctc   1440

tcactaacta atcactttcc catcttttgt tagatttgaa tatatacatt ctatgatcat   1500

tgctttttct ctttacaggg gagaatttca tattttacct gagcaaattg attagaaaat   1560

ggaaccacta gaggaatata atgtgttagg aaattacagt catttctaag ggcccagccc   1620

ttgacaaaat tgtgaagtta aattctccac tctgtccatc agatactatg gttctccact   1680

atggcaacta actcactcaa ttttccctcc ttagcagcat tccatcttcc cgatcttctt   1740

tgcttctcca accaaaacat caatgtttat tagttctgta tacagtacag gatctttggt   1800

ctactctatc acaaggccag taccacactc atgaagaaag aacacaggag tagctgagag   1860

gctaaaactc atcaaaaaca ctactccttt tcctctaccc tattcctcaa tcttttacct   1920

tttccaaatc ccaatcccca aatcagtttt tctctttctt actccctctc tcccttttac   1980

cctccatggt cgttaaagga gagatgggga gcatcattct gttatacttc tgtacacagt   2040

tatacatgtc tatcaaaccc agacttgctt ccatagtgga gacttgcttt tcagaacata   2100

gggatgaagt aaggtgcctg aaaagtttgg gggaaaagtt tctttcagag agttaagtta   2160

ttttatatat ataatatata tataaaatat ataatataca atataaatat atagtgtgtg   2220

tgtgtatgcg tgtgtgtaga cacacacgca tacacacata taatggaagc aataagccat   2280

tctaagagct tgtatggtta tggaggtctg actaggcatg atttcacgaa ggcaagattg   2340

gcatatcatt gtaactaaaa aagctgacat tgacccagac atattgtact ctttctaaaa   2400

ataataataa taatgctaac agaaagaaga gaaccgttcg tttgcaatct acagctagta   2460

gagactttga ggaagaattc aacagtgtgt cttcagcagt gttcagagcc aagcaagaag   2520

ttgaagttgc ctagaccaga ggacataagt atcatgtctc ctttaactag cataccccga   2580

agtggagaag ggtgcagcag gctcaaaggc ataagtcatt ccaatcagcc aactaagttg   2640

tccttttctg gtttcgtgtt caccatggaa cattttgatt atagttaatc cttctatctt   2700

gaatcttcta gagagttgct gaccaactga cgtatgtttc cctttgtgaa ttaataaact   2760

ggtgttctgg ttcat                                                    2775


<210>  11
<211>  2775
<212>  DNA
<213>  Homo sapiens


<220>
<221>  DNA
<222>  (1)..(2775)
<223>  IX-3
<400>  11
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta     60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt    120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt    180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac    240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat    300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc    360

tttggatttg aaggaaagaa ctgtgaatta gatgcaacat gtaacattaa gaatggcaga    420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga    480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga    540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac    600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca    660

tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg    720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa    780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt    840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt    900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa    960

ctggacgcac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa   1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc   1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc   1140

acatgtcttc gatctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat   1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa   1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa   1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc   1380

acttaatgaa agatggattt ccaaggttaa ttcattggaa ttgaaaatta acagggcctc   1440

tcactaacta atcactttcc catcttttgt tagatttgaa tatatacatt ctatgatcat   1500

tgctttttct ctttacaggg gagaatttca tattttacct gagcaaattg attagaaaat   1560

ggaaccacta gaggaatata atgtgttagg aaattacagt catttctaag ggcccagccc   1620

ttgacaaaat tgtgaagtta aattctccac tctgtccatc agatactatg gttctccact   1680

atggcaacta actcactcaa ttttccctcc ttagcagcat tccatcttcc cgatcttctt   1740

tgcttctcca accaaaacat caatgtttat tagttctgta tacagtacag gatctttggt   1800

ctactctatc acaaggccag taccacactc atgaagaaag aacacaggag tagctgagag   1860

gctaaaactc atcaaaaaca ctactccttt tcctctaccc tattcctcaa tcttttacct   1920

tttccaaatc ccaatcccca aatcagtttt tctctttctt actccctctc tcccttttac   1980

cctccatggt cgttaaagga gagatgggga gcatcattct gttatacttc tgtacacagt   2040

tatacatgtc tatcaaaccc agacttgctt ccatagtgga gacttgcttt tcagaacata   2100

gggatgaagt aaggtgcctg aaaagtttgg gggaaaagtt tctttcagag agttaagtta   2160

ttttatatat ataatatata tataaaatat ataatataca atataaatat atagtgtgtg   2220

tgtgtatgcg tgtgtgtaga cacacacgca tacacacata taatggaagc aataagccat   2280

tctaagagct tgtatggtta tggaggtctg actaggcatg atttcacgaa ggcaagattg   2340

gcatatcatt gtaactaaaa aagctgacat tgacccagac atattgtact ctttctaaaa   2400

ataataataa taatgctaac agaaagaaga gaaccgttcg tttgcaatct acagctagta   2460

gagactttga ggaagaattc aacagtgtgt cttcagcagt gttcagagcc aagcaagaag   2520

ttgaagttgc ctagaccaga ggacataagt atcatgtctc ctttaactag cataccccga   2580

agtggagaag ggtgcagcag gctcaaaggc ataagtcatt ccaatcagcc aactaagttg   2640

tccttttctg gtttcgtgtt caccatggaa cattttgatt atagttaatc cttctatctt   2700

gaatcttcta gagagttgct gaccaactga cgtatgtttc cctttgtgaa ttaataaact   2760

ggtgttctgg ttcat                                                    2775


<210>  12
<211>  2775
<212>  DNA
<213>  Homo sapiens


<220>
<221>  DNA
<222>  (1)..(2775)
<223>  IX-4
<400>  12
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta     60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt    120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt    180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac    240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat    300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc    360

tttggatttg aaggaaagaa ctgtgaatta gatgcaacat gtaacattaa gaatggcaga    420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga    480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga    540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac    600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca    660

tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg    720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa    780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt    840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt    900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa    960

ctggacgaac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa   1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc   1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc   1140

acatgtcttg catctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat   1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa   1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa   1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc   1380

acttaatgaa agatggattt ccaaggttaa ttcattggaa ttgaaaatta acagggcctc   1440

tcactaacta atcactttcc catcttttgt tagatttgaa tatatacatt ctatgatcat   1500

tgctttttct ctttacaggg gagaatttca tattttacct gagcaaattg attagaaaat   1560

ggaaccacta gaggaatata atgtgttagg aaattacagt catttctaag ggcccagccc   1620

ttgacaaaat tgtgaagtta aattctccac tctgtccatc agatactatg gttctccact   1680

atggcaacta actcactcaa ttttccctcc ttagcagcat tccatcttcc cgatcttctt   1740

tgcttctcca accaaaacat caatgtttat tagttctgta tacagtacag gatctttggt   1800

ctactctatc acaaggccag taccacactc atgaagaaag aacacaggag tagctgagag   1860

gctaaaactc atcaaaaaca ctactccttt tcctctaccc tattcctcaa tcttttacct   1920

tttccaaatc ccaatcccca aatcagtttt tctctttctt actccctctc tcccttttac   1980

cctccatggt cgttaaagga gagatgggga gcatcattct gttatacttc tgtacacagt   2040

tatacatgtc tatcaaaccc agacttgctt ccatagtgga gacttgcttt tcagaacata   2100

gggatgaagt aaggtgcctg aaaagtttgg gggaaaagtt tctttcagag agttaagtta   2160

ttttatatat ataatatata tataaaatat ataatataca atataaatat atagtgtgtg   2220

tgtgtatgcg tgtgtgtaga cacacacgca tacacacata taatggaagc aataagccat   2280

tctaagagct tgtatggtta tggaggtctg actaggcatg atttcacgaa ggcaagattg   2340

gcatatcatt gtaactaaaa aagctgacat tgacccagac atattgtact ctttctaaaa   2400

ataataataa taatgctaac agaaagaaga gaaccgttcg tttgcaatct acagctagta   2460

gagactttga ggaagaattc aacagtgtgt cttcagcagt gttcagagcc aagcaagaag   2520

ttgaagttgc ctagaccaga ggacataagt atcatgtctc ctttaactag cataccccga   2580

agtggagaag ggtgcagcag gctcaaaggc ataagtcatt ccaatcagcc aactaagttg   2640

tccttttctg gtttcgtgtt caccatggaa cattttgatt atagttaatc cttctatctt   2700

gaatcttcta gagagttgct gaccaactga cgtatgtttc cctttgtgaa ttaataaact   2760

ggtgttctgg ttcat                                                    2775


<210>  13
<211>  2775
<212>  DNA
<213>  Homo sapiens


<220>
<221>  DNA
<222>  (1)..(2775)
<223>  IX-5
<400>  13
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta     60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt    120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt    180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac    240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat    300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc    360

tttggatttg aaggaaagaa ctgtgaatta gatgtaacat gtaacattaa gaatggcaga    420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga    480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga    540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac    600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca    660

tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg    720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa    780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt    840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt    900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa    960

ctggacgcac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa   1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc   1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc   1140

acatgtcttg catctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat   1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa   1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa   1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc   1380

acttaatgaa agatggattt ccaaggttaa ttcattggaa ttgaaaatta acagggcctc   1440

tcactaacta atcactttcc catcttttgt tagatttgaa tatatacatt ctatgatcat   1500

tgctttttct ctttacaggg gagaatttca tattttacct gagcaaattg attagaaaat   1560

ggaaccacta gaggaatata atgtgttagg aaattacagt catttctaag ggcccagccc   1620

ttgacaaaat tgtgaagtta aattctccac tctgtccatc agatactatg gttctccact   1680

atggcaacta actcactcaa ttttccctcc ttagcagcat tccatcttcc cgatcttctt   1740

tgcttctcca accaaaacat caatgtttat tagttctgta tacagtacag gatctttggt   1800

ctactctatc acaaggccag taccacactc atgaagaaag aacacaggag tagctgagag   1860

gctaaaactc atcaaaaaca ctactccttt tcctctaccc tattcctcaa tcttttacct   1920

tttccaaatc ccaatcccca aatcagtttt tctctttctt actccctctc tcccttttac   1980

cctccatggt cgttaaagga gagatgggga gcatcattct gttatacttc tgtacacagt   2040

tatacatgtc tatcaaaccc agacttgctt ccatagtgga gacttgcttt tcagaacata   2100

gggatgaagt aaggtgcctg aaaagtttgg gggaaaagtt tctttcagag agttaagtta   2160

ttttatatat ataatatata tataaaatat ataatataca atataaatat atagtgtgtg   2220

tgtgtatgcg tgtgtgtaga cacacacgca tacacacata taatggaagc aataagccat   2280

tctaagagct tgtatggtta tggaggtctg actaggcatg atttcacgaa ggcaagattg   2340

gcatatcatt gtaactaaaa aagctgacat tgacccagac atattgtact ctttctaaaa   2400

ataataataa taatgctaac agaaagaaga gaaccgttcg tttgcaatct acagctagta   2460

gagactttga ggaagaattc aacagtgtgt cttcagcagt gttcagagcc aagcaagaag   2520

ttgaagttgc ctagaccaga ggacataagt atcatgtctc ctttaactag cataccccga   2580

agtggagaag ggtgcagcag gctcaaaggc ataagtcatt ccaatcagcc aactaagttg   2640

tccttttctg gtttcgtgtt caccatggaa cattttgatt atagttaatc cttctatctt   2700

gaatcttcta gagagttgct gaccaactga cgtatgtttc cctttgtgaa ttaataaact   2760

ggtgttctgg ttcat                                                    2775


<210>  14
<211>  2775
<212>  DNA
<213>  Homo sapiens


<220>
<221>  DNA
<222>  (1)..(2775)
<223>  IX-6
<400>  14
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta     60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt    120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt    180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac    240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat    300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc    360

tttggatttg aaggaaagaa ctgtgaatta gatgcaacat gtaacattaa gaatggcaga    420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga    480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga    540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac    600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca    660

tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg    720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa    780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt    840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt    900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa    960

ctggacgcac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa   1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc   1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc   1140

acatgtcttg catctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat   1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa   1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa   1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc   1380

acttaatgaa agatggattt ccaaggttaa ttcattggaa ttgaaaatta acagggcctc   1440

tcactaacta atcactttcc catcttttgt tagatttgaa tatatacatt ctatgatcat   1500

tgctttttct ctttacaggg gagaatttca tattttacct gagcaaattg attagaaaat   1560

ggaaccacta gaggaatata atgtgttagg aaattacagt catttctaag ggcccagccc   1620

ttgacaaaat tgtgaagtta aattctccac tctgtccatc agatactatg gttctccact   1680

atggcaacta actcactcaa ttttccctcc ttagcagcat tccatcttcc cgatcttctt   1740

tgcttctcca accaaaacat caatgtttat tagttctgta tacagtacag gatctttggt   1800

ctactctatc acaaggccag taccacactc atgaagaaag aacacaggag tagctgagag   1860

gctaaaactc atcaaaaaca ctactccttt tcctctaccc tattcctcaa tcttttacct   1920

tttccaaatc ccaatcccca aatcagtttt tctctttctt actccctctc tcccttttac   1980

cctccatggt cgttaaagga gagatgggga gcatcattct gttatacttc tgtacacagt   2040

tatacatgtc tatcaaaccc agacttgctt ccatagtgga gacttgcttt tcagaacata   2100

gggatgaagt aaggtgcctg aaaagtttgg gggaaaagtt tctttcagag agttaagtta   2160

ttttatatat ataatatata tataaaatat ataatataca atataaatat atagtgtgtg   2220

tgtgtatgcg tgtgtgtaga cacacacgca tacacacata taatggaagc aataagccat   2280

tctaagagct tgtatggtta tggaggtctg actaggcatg atttcacgaa ggcaagattg   2340

gcatatcatt gtaactaaaa aagctgacat tgacccagac atattgtact ctttctaaaa   2400

ataataataa taatgctaac agaaagaaga gaaccgttcg tttgcaatct acagctagta   2460

gagactttga ggaagaattc aacagtgtgt cttcagcagt gttcagagcc aagcaagaag   2520

ttgaagttgc ctagaccaga ggacataagt atcatgtctc ctttaactag cataccccga   2580

agtggagaag ggtgcagcag gctcaaaggc ataagtcatt ccaatcagcc aactaagttg   2640

tccttttctg gtttcgtgtt caccatggaa cattttgatt atagttaatc cttctatctt   2700

gaatcttcta gagagttgct gaccaactga cgtatgtttc cctttgtgaa ttaataaact   2760

ggtgttctgg ttcat                                                    2775


<210>  15
<211>  2775
<212>  DNA
<213>  Homo sapiens


<220>
<221>  DNA
<222>  (1)..(2775)
<223>  IX-7
<400>  15
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta     60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt    120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt    180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac    240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat    300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc    360

tttggatttg aaggaaagaa ctgtgaatta gatgtaacat gtaacattaa gaatggcaga    420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga    480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga    540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac    600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca    660

tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg    720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa    780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt    840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt    900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa    960

ctggacgaac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa   1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc   1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc   1140

acatgtcttc gatctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat   1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa   1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa   1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc   1380

acttaatgaa agatggattt ccaaggttaa ttcattggaa ttgaaaatta acagggcctc   1440

tcactaacta atcactttcc catcttttgt tagatttgaa tatatacatt ctatgatcat   1500

tgctttttct ctttacaggg gagaatttca tattttacct gagcaaattg attagaaaat   1560

ggaaccacta gaggaatata atgtgttagg aaattacagt catttctaag ggcccagccc   1620

ttgacaaaat tgtgaagtta aattctccac tctgtccatc agatactatg gttctccact   1680

atggcaacta actcactcaa ttttccctcc ttagcagcat tccatcttcc cgatcttctt   1740

tgcttctcca accaaaacat caatgtttat tagttctgta tacagtacag gatctttggt   1800

ctactctatc acaaggccag taccacactc atgaagaaag aacacaggag tagctgagag   1860

gctaaaactc atcaaaaaca ctactccttt tcctctaccc tattcctcaa tcttttacct   1920

tttccaaatc ccaatcccca aatcagtttt tctctttctt actccctctc tcccttttac   1980

cctccatggt cgttaaagga gagatgggga gcatcattct gttatacttc tgtacacagt   2040

tatacatgtc tatcaaaccc agacttgctt ccatagtgga gacttgcttt tcagaacata   2100

gggatgaagt aaggtgcctg aaaagtttgg gggaaaagtt tctttcagag agttaagtta   2160

ttttatatat ataatatata tataaaatat ataatataca atataaatat atagtgtgtg   2220

tgtgtatgcg tgtgtgtaga cacacacgca tacacacata taatggaagc aataagccat   2280

tctaagagct tgtatggtta tggaggtctg actaggcatg atttcacgaa ggcaagattg   2340

gcatatcatt gtaactaaaa aagctgacat tgacccagac atattgtact ctttctaaaa   2400

ataataataa taatgctaac agaaagaaga gaaccgttcg tttgcaatct acagctagta   2460

gagactttga ggaagaattc aacagtgtgt cttcagcagt gttcagagcc aagcaagaag   2520

ttgaagttgc ctagaccaga ggacataagt atcatgtctc ctttaactag cataccccga   2580

agtggagaag ggtgcagcag gctcaaaggc ataagtcatt ccaatcagcc aactaagttg   2640

tccttttctg gtttcgtgtt caccatggaa cattttgatt atagttaatc cttctatctt   2700

gaatcttcta gagagttgct gaccaactga cgtatgtttc cctttgtgaa ttaataaact   2760

ggtgttctgg ttcat                                                    2775


<210>  16
<211>  2775
<212>  DNA
<213>  Homo sapiens


<220>
<221>  DNA
<222>  (1)..(2775)
<223>  IX-8
<400>  16
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta     60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt    120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt    180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac    240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat    300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc    360

tttggatttg aaggaaagaa ctgtgaatta gatgtaacat gtaacattaa gaatggcaga    420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga    480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga    540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac    600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca    660

tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg    720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa    780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt    840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt    900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa    960

ctggacgaac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa   1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc   1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc   1140

acatgtcttg catctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat   1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa   1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa   1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc   1380

acttaatgaa agatggattt ccaaggttaa ttcattggaa ttgaaaatta acagggcctc   1440

tcactaacta atcactttcc catcttttgt tagatttgaa tatatacatt ctatgatcat   1500

tgctttttct ctttacaggg gagaatttca tattttacct gagcaaattg attagaaaat   1560

ggaaccacta gaggaatata atgtgttagg aaattacagt catttctaag ggcccagccc   1620

ttgacaaaat tgtgaagtta aattctccac tctgtccatc agatactatg gttctccact   1680

atggcaacta actcactcaa ttttccctcc ttagcagcat tccatcttcc cgatcttctt   1740

tgcttctcca accaaaacat caatgtttat tagttctgta tacagtacag gatctttggt   1800

ctactctatc acaaggccag taccacactc atgaagaaag aacacaggag tagctgagag   1860

gctaaaactc atcaaaaaca ctactccttt tcctctaccc tattcctcaa tcttttacct   1920

tttccaaatc ccaatcccca aatcagtttt tctctttctt actccctctc tcccttttac   1980

cctccatggt cgttaaagga gagatgggga gcatcattct gttatacttc tgtacacagt   2040

tatacatgtc tatcaaaccc agacttgctt ccatagtgga gacttgcttt tcagaacata   2100

gggatgaagt aaggtgcctg aaaagtttgg gggaaaagtt tctttcagag agttaagtta   2160

ttttatatat ataatatata tataaaatat ataatataca atataaatat atagtgtgtg   2220

tgtgtatgcg tgtgtgtaga cacacacgca tacacacata taatggaagc aataagccat   2280

tctaagagct tgtatggtta tggaggtctg actaggcatg atttcacgaa ggcaagattg   2340

gcatatcatt gtaactaaaa aagctgacat tgacccagac atattgtact ctttctaaaa   2400

ataataataa taatgctaac agaaagaaga gaaccgttcg tttgcaatct acagctagta   2460

gagactttga ggaagaattc aacagtgtgt cttcagcagt gttcagagcc aagcaagaag   2520

ttgaagttgc ctagaccaga ggacataagt atcatgtctc ctttaactag cataccccga   2580

agtggagaag ggtgcagcag gctcaaaggc ataagtcatt ccaatcagcc aactaagttg   2640

tccttttctg gtttcgtgtt caccatggaa cattttgatt atagttaatc cttctatctt   2700

gaatcttcta gagagttgct gaccaactga cgtatgtttc cctttgtgaa ttaataaact   2760

ggtgttctgg ttcat                                                    2775

<210>  17
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  forward PCR primer IX86

<220>
<221>  primer
<222>  (1)..(21)

<400>  17
gtgaattaga tgcaacatgt a                                               21


<210>  18
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223> reverse PCR IX86T7


<220>
<221>  primer
<222>  (1)..(24)

<400>  18
tgttacatgt tgcatctaat tcac                                            24


<210>  19
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  forward PCR primer IX277


<220>
<221>  primer
<222>  (1)..(22)

<400>  19
gaactggacg cacccttagt gc                                              22


<210>  20
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  reverse PCR primer IX277-2


<220>
<221>  primer
<222>  (1)..(22)

<400>  20
ctaagggtgc gtccagttcc ag                                              22


<210>  21
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  forward PCR primer IX338


<220>
<221>  primer
<222>  (1)..(20)

<400>  21
catgtcttgc atctacaaag                                                 20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  reverse PCR primer IX338D


<220>
<221>  primer
<222>  (1)..(20)

<400>  22
ctttgtagat gcaagacatg                                                 20


<210>  23
<211>  415
<212>  PRT
<213>  Homo sapiens

<220>
<221>  Protein
<222>  (1)..(415)
<223>  E213A
<400>  23

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             
Ser Ile Val Asn Ala Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  24
<211>  415
<212>  PRT
<213>  Homo sapiens

<220>
<221>  Protein
<222>  (1)..(415)
<223>  K228A
<400>  24

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 
Thr Gly Val Ala Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  25
<211>  415
<212>  PRT
<213>  Homo sapiens

<220>
<221>  Protein
<222>  (1)..(415)
<223>  E240A
<400>  25

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Ala 
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  26
<211>  415
<212>  PRT
<213>  Homo sapiens

<220>
<221>  Protein
<222>  (1)..(415)
<223>  K247A
<400>  26

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Ala Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         
Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 

<210>  27
<211>  415
<212>  PRT
<213>  Homo sapiens

<220>
<221>  Protein
<222>  (1)..(415)
<223>  D276A
<400>  27

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      
Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          
Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              
Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  
Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  
Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      
Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         
Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             
Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 
Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 
Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     
Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         
Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             
Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 
Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 
Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     
His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         
Leu Glu Leu Ala Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             
Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 
Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 
Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     
Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         
Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             
His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 
Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 
Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 

                                    

<210>  28
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  forward factor IX specific primer

<220>
<221>  primer
<222>  (1)..(19)

<400>  28
ggaagcagtatgttgatgg                                              19

<210>  29
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  reverse factor IX specific primer

<220>
<221>  primer
<222>  (1)..(20)

<400>  29
tggttcacaggacttctggt                                                    20
 
