                         SEQUENCE LISTING

<110> IMCLONE SYSTEMS, INC.
 
<120> STABLE ANTIBODY FORMULATIONS

<130> 1017.53406-PCT

<140> 
<141> 

<150> 60/919,744
<151> 2007-03-22

<160> 6     

<170> PatentIn version 3.3

<210> 1
<211> 1383
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(1380)

<400> 1
gag gtc cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg tcc       48
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser         
1               5                   10                  15              

tcg gtg aag gtc tcc tgc aag gct tct gga ggc acc ttc agc agc tat       96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr         
            20                  25                  30                  

gct atc agc tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg      144
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met         
        35                  40                  45                      

gga ggg atc atc cct atc ttt ggt aca gca aac tac gca cag aag ttc      192
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe         
    50                  55                  60                          

cag ggc aga gtc acg att acc gcg gac aaa tcc acg agc aca gcc tac      240
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctg agc agc ctg aga tct gag gac acg gcc gtg tat tac tgt      288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys         
                85                  90                  95              

gcg aga gcg cca tta cga ttt ttg gag tgg tcc acc caa gac cac tac      336
Ala Arg Ala Pro Leu Arg Phe Leu Glu Trp Ser Thr Gln Asp His Tyr         
            100                 105                 110                 

tac tac tac tac atg gac gtc tgg ggc aaa ggg acc acg gtc acc gtc      384
Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val         
        115                 120                 125                     

tca agc gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc      432
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser         
    130                 135                 140                         

tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag      480
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys         
145                 150                 155                 160         

gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg      528
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu         
                165                 170                 175             

acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc      576
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu         
            180                 185                 190                 

tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc      624
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr         
        195                 200                 205                     

cag acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg      672
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val         
    210                 215                 220                         

gac aag aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca      720
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro         
225                 230                 235                 240         

ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc      768
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe         
                245                 250                 255             

ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc      816
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val         
            260                 265                 270                 

aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc      864
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe         
        275                 280                 285                     

aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg      912
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro         
    290                 295                 300                         

cgg gag gag cag tac aac agc acg tac cgg gtg gtc agc gtc ctc acc      960
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr         
305                 310                 315                 320         

gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc     1008
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val         
                325                 330                 335             

tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc     1056
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala         
            340                 345                 350                 

aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg     1104
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg         
        355                 360                 365                     

gag gag atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc     1152
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly         
    370                 375                 380                         

ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg     1200
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro         
385                 390                 395                 400         

gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc     1248
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser         
                405                 410                 415             

ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag     1296
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln         
            420                 425                 430                 

ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac     1344
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His         
        435                 440                 445                     

tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa tga                 1383
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                         
    450                 455                 460                         


<210> 2
<211> 460
<212> PRT
<213> Homo sapiens

<400> 2
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          

Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Pro Leu Arg Phe Leu Glu Trp Ser Thr Gln Asp His Tyr 
            100                 105                 110         

Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
        115                 120                 125             

Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 

Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 

Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     

Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         

Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        195                 200                 205             

Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 

Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     

Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         

Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        275                 280                 285             

Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 

Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 

Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     

Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         

Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        355                 360                 365             

Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 

Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 

Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     

Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            420                 425                 430         

Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             

Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460 


<210> 3
<211> 645
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(642)

<400> 3
tct tct gag ctg act cag gac cct gct gtg tct gtg gcc ttg gga cag       48
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln         
1               5                   10                  15              

aca gtc agg atc aca tgc caa gga gac agc ctc aga agc tat tat gca       96
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala         
            20                  25                  30                  

acc tgg tac cag cag aag cca gga cag gcc cct att ctt gtc atc tat      144
Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ile Leu Val Ile Tyr         
        35                  40                  45                      

ggt gaa aat aag cgg ccc tca ggg atc cca gac cga ttc tct ggc tcc      192
Gly Glu Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser         
    50                  55                  60                          

agc tca gga aac aca gct tcc ttg acc atc act ggg gct cag gca gaa      240
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu         
65                  70                  75                  80          

gat gag gct gac tac tat tgt aaa tct cgg gat ggc agt ggt caa cat      288
Asp Glu Ala Asp Tyr Tyr Cys Lys Ser Arg Asp Gly Ser Gly Gln His         
                85                  90                  95              

ctg gtg ttc ggc gga ggg acc aag ctg acc gtc cta ggt cag ccc aag      336
Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys         
            100                 105                 110                 

gct gcc ccc tcg gtc act ctg ttc ccg ccc tcc tct gag gag ctt caa      384
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln         
        115                 120                 125                     

gcc aac aag gcc aca ctg gtg tgt ctc ata agt gac ttc tac ccg gga      432
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly         
    130                 135                 140                         

gcc gtg aca gtg gcc tgg aag gca gat agc agc ccc gtc aag gcg gga      480
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly         
145                 150                 155                 160         

gtg gag acc acc aca ccc tcc aaa caa agc aac aac aag tac gcg gcc      528
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala         
                165                 170                 175             

agc agc tat ctg agc ctg acg cct gag cag tgg aag tcc cac aga agc      576
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser         
            180                 185                 190                 

tac agc tgc cag gtc acg cat gaa ggg agc acc gtg gag aag aca gtg      624
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val         
        195                 200                 205                     

gcc cct gca gaa tgc tct tga                                          645
Ala Pro Ala Glu Cys Ser                                                 
    210                                                                 


<210> 4
<211> 214
<212> PRT
<213> Homo sapiens

<400> 4
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          

Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ile Leu Val Ile Tyr 
        35                  40                  45              

Gly Glu Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  

Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Lys Ser Arg Asp Gly Ser Gly Gln His 
                85                  90                  95      

Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         

Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             

Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 

Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 

Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     

Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         

Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             

Ala Pro Ala Glu Cys Ser 
    210                 


<210> 5
<211> 645
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(642)

<400> 5
tct tct gag ctg act cag gac cct gct gtg tct gtg gcc ttg gga cag       48
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln         
1               5                   10                  15              

aca gtc agg atc aca tgc caa gga gac agc ctc aga agc tat tat gca       96
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala         
            20                  25                  30                  

agc tgg tac cag cag aag cca gga cag gcc cct gta ctt gtc atc tat      144
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr         
        35                  40                  45                      

ggt aaa aac aac cgg ccc tca ggg atc cca gac cga ttc tct ggc tcc      192
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser         
    50                  55                  60                          

agc tca gga aac aca gct tcc ttg acc atc act ggg gct cag gcg gaa      240
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu         
65                  70                  75                  80          

gat gag gct gac tat tac tgt aac tcc cgg gac aac agt gat aac cgt      288
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Asn Ser Asp Asn Arg         
                85                  90                  95              

ctg ata ttt ggc ggc ggg acc aag ctg acc gtc ctc agt cag ccc aag      336
Leu Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gln Pro Lys         
            100                 105                 110                 

gct gcc ccc tcg gtc act ctg ttc ccg ccc tcc tct gag gag ctt caa      384
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln         
        115                 120                 125                     

gcc aac aag gcc aca ctg gtg tgt ctc ata agt gac ttc tac ccg gga      432
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly         
    130                 135                 140                         

gcc gtg aca gtg gcc tgg aag gca gat agc agc ccc gtc aag gcg gga      480
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly         
145                 150                 155                 160         

gtg gag acc acc aca ccc tcc aaa caa agc aac aac aag tac gcg gcc      528
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala         
                165                 170                 175             

agc agc tat ctg agc ctg acg cct gag cag tgg aag tcc cac aga agc      576
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser         
            180                 185                 190                 

tac agc tgc cag gtc acg cat gaa ggg agc acc gtg gag aag aca gtg      624
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val         
        195                 200                 205                     

gcc cct gca gaa tgc tct tga                                          645
Ala Pro Ala Glu Cys Ser                                                 
    210                                                                 


<210> 6
<211> 214
<212> PRT
<213> Homo sapiens

<400> 6
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          

Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              

Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  

Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Asn Ser Asp Asn Arg 
                85                  90                  95      

Leu Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gln Pro Lys 
            100                 105                 110         

Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             

Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 

Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 

Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     

Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         

Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             

Ala Pro Ala Glu Cys Ser 
    210                 


 
 

