
                                SEQUENCE LISTING

<110> Novartis Vaccines & Diagnostics

<120> APCDD1 INHIBITORS FOR TREATING,
  DIAGNOSING OR DETECTING CANCER
  

<130> 20366-136WO1

<150> US 60/894,806       
<151> 2007-03-14  

<160> 25

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2572
<212> DNA
<213> Homo sapiens

<400> 1
gaaatatgaa gagacgctgc agctgcggtg gcggtggcgg ccactgcagc tcagagcggc 60
gcacgcggcg gccggggcgg gacgcggggc cgggcgcgga gaagtcgggg cgggcggcag 120
agaggccggg acgcggaccg ggccggggcg cccacagccg cccgacggcg cccagagagc 180
gcgcgccccg cagccccgcg cctagcccgc cgggcatggg gcgcgcggca gccgcctgaa 240
gccccggcct ggcccggccg cacccggccg gaggggaggg cagagcgcgc gcccagttgc 300
ccgggcacca aatcggagcg cggcgtgcgg gagggcccag agcaggactg gaaatgtcct 360
ggccgcgccg cctcctgctc agatacctgt tcccggccct cctgcttcac gggctgggag 420
agggttctgc cctccttcat ccagacagca ggtctcatcc taggtcctta gagaaaagtg 480
cctggagggc ttttaaggag tcacagtgcc atcacatgct caaacatctc cacaatggtg 540
caaggatcac agtgcagatg ccacctacaa tcgagggcca ctgggtctcc acaggctgtg 600
aagtaaggtc aggcccagag ttcatcacaa ggtcctacag attctaccac aataacacct 660
tcaaggccta ccaattttat tatggcagca accggtgcac aaatcccact tatactctca 720
tcatccgggg caagatccgc ctccgccagg cctcctggat catccgaggg ggcacggaag 780
ccgactacca gctgcacaac gtccaggtga tctgccacac agaggcggtg gccgagaagc 840
tcggccagca ggtgaaccgc acatgcccgg gcttcctcgc agacgggggt ccctgggtgc 900
aggacgtggc ctatgacctc tggcgagagg agaacggctg tgagtgcacc aaggccgtga 960
actttgccat gcatgaactt cagctcatcc gggtggagaa gcagtacctt caccacaacc 1020
tcgaccacct ggtcgaggag ctcttccttg gtgacattca cactgatgcc acccagagga 1080
tgttctaccg gccctccagt taccagcccc ctctgcagaa tgccaagaac cacgaccatg 1140
cctgcatcgc ctgtcggatc atctatcggt cagacgagca ccaccctccc atcctgcccc 1200
caaaggcaga cctgaccatc ggcctgcacg gggagtgggt gagccagcgc tgtgaggtgc 1260
gccccgaagt cctcttcctc acccgccact tcatcttcca tgacaacaac aacacctggg 1320
agggccacta ctaccactac tcagacccgg tgtgcaagca ccccaccttc tccatctacg 1380
cccggggccg ctacagccgc ggcgtcctct cgtccagggt catgggaggc accgagttcg 1440
tgttcaaagt gaatcacatg aaggtcaccc ccatggatgc ggccacagcc tcactgctca 1500
acgtcttcaa cgggaatgag tgcggggccg agggctcctg gcaggtgggc atccagcagg 1560
atgtgaccca caccaatggc tgcgtggccc tgggcatcaa actacctcac acggagtacg 1620
agatcttcaa aatggaacag gatgcccggg ggcgctatct gctgttcaac ggtcagaggc 1680
ccagcgacgg gtccagccca gacaggccag agaagagagc cacgtcctac cagatgccct 1740
tggtccagtg tgcctcctct tcgccgaggg cagaggacct cgcagaagac agtggaagca 1800
gcctgtatgg ccgggcccct gggaggcaca cctggtccct gctgctggct gcacttgcct 1860
gccttgtccc tctgctgcat tggaacatcc gcagatagaa gttttagaaa gttctatttt 1920
ttccaaacca ggattcctta ctattgacag atttgcttta ccaaaagaaa agacatttat 1980
tcttttgatg cacttgaatg ccagagaact gtccttcttt ttctcctctc cctccctccc 2040
agcccctgag tcatgaacag caaggagtgt ttgaagtttc tgctttgaac tccgtccagc 2100
ctgatccctg gcctgagcaa cttcacaaca gtaattgcac tttaagacag cctagagttc 2160
tggacgagcg tgtttggtag cagggatgaa agctagggcc tcttattttt ttctcttaat 2220
tattattata tttctgagtt aaacttagaa gaaacaacta tcaagctaca acttttcctg 2280
ccattttcct gtggttgcag cctgtcttcc tttgaaattg ttttactctc tgagttttat 2340
atgctggaat ccaatgcaga gttggtttgg gactgtgatc aagacacctt ttattaataa 2400
agaagagaca caggtgtaga tatgtatata caaaaagatg tacggtctgg ccaaaccacc 2460
ttcccagcct ttatgcaaaa aaaggggaga atcaaagctt tcatttcaga aatgttgcgt 2520
ggaaaagtat ctgtaattaa agtttcgaag taatttaaaa aaaaaaaaaa aa         2572

<210> 2
<211> 514
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu
 1               5                  10                  15      
Leu Leu His Gly Leu Gly Glu Gly Ser Ala Leu Leu His Pro Asp Ser
            20                  25                  30          
Arg Ser His Pro Arg Ser Leu Glu Lys Ser Ala Trp Arg Ala Phe Lys
        35                  40                  45              
Glu Ser Gln Cys His His Met Leu Lys His Leu His Asn Gly Ala Arg
    50                  55                  60                  
Ile Thr Val Gln Met Pro Pro Thr Ile Glu Gly His Trp Val Ser Thr
65                  70                  75                  80  
Gly Cys Glu Val Arg Ser Gly Pro Glu Phe Ile Thr Arg Ser Tyr Arg
                85                  90                  95      
Phe Tyr His Asn Asn Thr Phe Lys Ala Tyr Gln Phe Tyr Tyr Gly Ser
            100                 105                 110         
Asn Arg Cys Thr Asn Pro Thr Tyr Thr Leu Ile Ile Arg Gly Lys Ile
        115                 120                 125             
Arg Leu Arg Gln Ala Ser Trp Ile Ile Arg Gly Gly Thr Glu Ala Asp
    130                 135                 140                 
Tyr Gln Leu His Asn Val Gln Val Ile Cys His Thr Glu Ala Val Ala
145                 150                 155                 160 
Glu Lys Leu Gly Gln Gln Val Asn Arg Thr Cys Pro Gly Phe Leu Ala
                165                 170                 175     
Asp Gly Gly Pro Trp Val Gln Asp Val Ala Tyr Asp Leu Trp Arg Glu
            180                 185                 190         
Glu Asn Gly Cys Glu Cys Thr Lys Ala Val Asn Phe Ala Met His Glu
        195                 200                 205             
Leu Gln Leu Ile Arg Val Glu Lys Gln Tyr Leu His His Asn Leu Asp
    210                 215                 220                 
His Leu Val Glu Glu Leu Phe Leu Gly Asp Ile His Thr Asp Ala Thr
225                 230                 235                 240 
Gln Arg Met Phe Tyr Arg Pro Ser Ser Tyr Gln Pro Pro Leu Gln Asn
                245                 250                 255     
Ala Lys Asn His Asp His Ala Cys Ile Ala Cys Arg Ile Ile Tyr Arg
            260                 265                 270         
Ser Asp Glu His His Pro Pro Ile Leu Pro Pro Lys Ala Asp Leu Thr
        275                 280                 285             
Ile Gly Leu His Gly Glu Trp Val Ser Gln Arg Cys Glu Val Arg Pro
    290                 295                 300                 
Glu Val Leu Phe Leu Thr Arg His Phe Ile Phe His Asp Asn Asn Asn
305                 310                 315                 320 
Thr Trp Glu Gly His Tyr Tyr His Tyr Ser Asp Pro Val Cys Lys His
                325                 330                 335     
Pro Thr Phe Ser Ile Tyr Ala Arg Gly Arg Tyr Ser Arg Gly Val Leu
            340                 345                 350         
Ser Ser Arg Val Met Gly Gly Thr Glu Phe Val Phe Lys Val Asn His
        355                 360                 365             
Met Lys Val Thr Pro Met Asp Ala Ala Thr Ala Ser Leu Leu Asn Val
    370                 375                 380                 
Phe Asn Gly Asn Glu Cys Gly Ala Glu Gly Ser Trp Gln Val Gly Ile
385                 390                 395                 400 
Gln Gln Asp Val Thr His Thr Asn Gly Cys Val Ala Leu Gly Ile Lys
                405                 410                 415     
Leu Pro His Thr Glu Tyr Glu Ile Phe Lys Met Glu Gln Asp Ala Arg
            420                 425                 430         
Gly Arg Tyr Leu Leu Phe Asn Gly Gln Arg Pro Ser Asp Gly Ser Ser
        435                 440                 445             
Pro Asp Arg Pro Glu Lys Arg Ala Thr Ser Tyr Gln Met Pro Leu Val
    450                 455                 460                 
Gln Cys Ala Ser Ser Ser Pro Arg Ala Glu Asp Leu Ala Glu Asp Ser
465                 470                 475                 480 
Gly Ser Ser Leu Tyr Gly Arg Ala Pro Gly Arg His Thr Trp Ser Leu
                485                 490                 495     
Leu Leu Ala Ala Leu Ala Cys Leu Val Pro Leu Leu His Trp Asn Ile
            500                 505                 510         
Arg Arg
        


<210> 3
<211> 468
<212> PRT
<213> Homo sapiens

<400> 3
Ala Leu Leu His Pro Asp Ser Arg Ser His Pro Arg Ser Leu Glu Lys
 1               5                  10                  15      
Ser Ala Trp Arg Ala Phe Lys Glu Ser Gln Cys His His Met Leu Lys
            20                  25                  30          
His Leu His Asn Gly Ala Arg Ile Thr Val Gln Met Pro Pro Thr Ile
        35                  40                  45              
Glu Gly His Trp Val Ser Thr Gly Cys Glu Val Arg Ser Gly Pro Glu
    50                  55                  60                  
Phe Ile Thr Arg Ser Tyr Arg Phe Tyr His Asn Asn Thr Phe Lys Ala
65                  70                  75                  80  
Tyr Gln Phe Tyr Tyr Gly Ser Asn Arg Cys Thr Asn Pro Thr Tyr Thr
                85                  90                  95      
Leu Ile Ile Arg Gly Lys Ile Arg Leu Arg Gln Ala Ser Trp Ile Ile
            100                 105                 110         
Arg Gly Gly Thr Glu Ala Asp Tyr Gln Leu His Asn Val Gln Val Ile
        115                 120                 125             
Cys His Thr Glu Ala Val Ala Glu Lys Leu Gly Gln Gln Val Asn Arg
    130                 135                 140                 
Thr Cys Pro Gly Phe Leu Ala Asp Gly Gly Pro Trp Val Gln Asp Val
145                 150                 155                 160 
Ala Tyr Asp Leu Trp Arg Glu Glu Asn Gly Cys Glu Cys Thr Lys Ala
                165                 170                 175     
Val Asn Phe Ala Met His Glu Leu Gln Leu Ile Arg Val Glu Lys Gln
            180                 185                 190         
Tyr Leu His His Asn Leu Asp His Leu Val Glu Glu Leu Phe Leu Gly
        195                 200                 205             
Asp Ile His Thr Asp Ala Thr Gln Arg Met Phe Tyr Arg Pro Ser Ser
    210                 215                 220                 
Tyr Gln Pro Pro Leu Gln Asn Ala Lys Asn His Asp His Ala Cys Ile
225                 230                 235                 240 
Ala Cys Arg Ile Ile Tyr Arg Ser Asp Glu His His Pro Pro Ile Leu
                245                 250                 255     
Pro Pro Lys Ala Asp Leu Thr Ile Gly Leu His Gly Glu Trp Val Ser
            260                 265                 270         
Gln Arg Cys Glu Val Arg Pro Glu Val Leu Phe Leu Thr Arg His Phe
        275                 280                 285             
Ile Phe His Asp Asn Asn Asn Thr Trp Glu Gly His Tyr Tyr His Tyr
    290                 295                 300                 
Ser Asp Pro Val Cys Lys His Pro Thr Phe Ser Ile Tyr Ala Arg Gly
305                 310                 315                 320 
Arg Tyr Ser Arg Gly Val Leu Ser Ser Arg Val Met Gly Gly Thr Glu
                325                 330                 335     
Phe Val Phe Lys Val Asn His Met Lys Val Thr Pro Met Asp Ala Ala
            340                 345                 350         
Thr Ala Ser Leu Leu Asn Val Phe Asn Gly Asn Glu Cys Gly Ala Glu
        355                 360                 365             
Gly Ser Trp Gln Val Gly Ile Gln Gln Asp Val Thr His Thr Asn Gly
    370                 375                 380                 
Cys Val Ala Leu Gly Ile Lys Leu Pro His Thr Glu Tyr Glu Ile Phe
385                 390                 395                 400 
Lys Met Glu Gln Asp Ala Arg Gly Arg Tyr Leu Leu Phe Asn Gly Gln
                405                 410                 415     
Arg Pro Ser Asp Gly Ser Ser Pro Asp Arg Pro Glu Lys Arg Ala Thr
            420                 425                 430         
Ser Tyr Gln Met Pro Leu Val Gln Cys Ala Ser Ser Ser Pro Arg Ala
        435                 440                 445             
Glu Asp Leu Ala Glu Asp Ser Gly Ser Ser Leu Tyr Gly Arg Ala Pro
    450                 455                 460                 
Gly Arg His Thr
465             


<210> 4
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu
 1               5                  10                  15      
Leu Leu His Gly Leu Gly Glu Gly Ser
            20                  25  


<210> 5
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 5
gcucaaacau cuccacaauu u                                           21

<210> 6
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 6
auuguggaga uguuugaccu u                                           21

<210> 7
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 7
cuucaaggcc uaccaauuuu u                                           21

<210> 8
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 8
aaauugguag gccuugaagu u                                           21

<210> 9
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 9
caaacuaccu cacacggagu u                                           21

<210> 10
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 10
cuccguguga gguaguuugu u                                           21

<210> 11
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 11
gcccagaguu caucacaagu u                                           21

<210> 12
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 12
cuugugauga acucugggcu u                                           21

<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 13
ggucucaucc uagguccuut t                                           21

<210> 14
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 14
aaggaccuag gaugagaacc tg                                          22

<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 15
gggcuuuuaa ggagucacat t                                           21

<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 16
ugugacuccu uaaaagccct c                                           21

<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 17
gguguagaua uguauauact t                                           21

<210> 18
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 18
guauauacau aucuacacct g                                           21

<210> 19
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 19
ucacuuugaa cacgaacucg gugcc                                       25

<210> 20
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 20
uuacuucaca gccuguggag accca                                       25

<210> 21
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 21
uaagugggau uugugcaccg guugc                                       25

<210> 22
<211> 16
<212> PRT
<213> Homo sapiens

<400> 22
Pro Ser Ser Tyr Gln Pro Pro Leu Gln Asn Ala Lys Asn His Asp His
 1               5                  10                  15      


<210> 23
<211> 20
<212> PRT
<213> Homo sapiens

<400> 23
Gln Arg Pro Ser Asp Gly Ser Ser Pro Asp Arg Pro Glu Lys Arg Ala
 1               5                  10                  15      
Thr Ser Tyr Gln
            20  


<210> 24
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 24
gtcgaggagc tcttccttgg tgacatt                                     27

<210> 25
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 25
tggtgctcgt ctgaccgata gatgat                                      26






