                         SEQUENCE LISTING

<110>  KIM, MANBOK
       RANCOURT, DERRICK E.
       ZUR NIEDEN, NICOLE
       JOHNSTON, RANDAL N.
 
<120>  ATTENUATED REOVIRUSES FOR SELECTION OF CELL POPULATIONS

<130>  UNTI:015WO

<140>  UNKNOWN
<141>  2008-03-13

<150>  60/906,710
<151>  2007-03-13


<160>  3     

<170>  PatentIn version 3.3

<210>  1
<211>  455
<212>  PRT
<213>  Mammalian orthoreovirus 2

<400>  1

Met Asp Pro Arg Leu Arg Glu Glu Val Val Arg Leu Ile Ile Ala Leu 
1               5                   10                  15      


Thr Ser Asp Asn Gly Ala Ser Leu Ser Lys Gly Leu Glu Ser Arg Val 
            20                  25                  30          


Ser Ala Leu Glu Lys Thr Ser Gln Ile His Ser Asp Thr Ile Leu Arg 
        35                  40                  45              


Ile Thr Gln Gly Leu Asp Asp Ala Asn Lys Arg Ile Ile Ala Leu Glu 
    50                  55                  60                  


Gln Ser Arg Asp Asp Leu Val Ala Ser Val Ser Asp Ala Gln Leu Ala 
65                  70                  75                  80  


Ile Ser Arg Leu Glu Ser Ser Ile Gly Ala Leu Gln Thr Val Val Asn 
                85                  90                  95      


Gly Leu Asp Ser Ser Val Thr Gln Leu Gly Ala Arg Val Gly Gln Leu 
            100                 105                 110         


Glu Thr Gly Leu Ala Asp Val Arg Val Asp His Asp Asn Leu Val Ala 
        115                 120                 125             


Arg Val Asp Thr Ala Glu Arg Asn Ile Gly Ser Leu Thr Thr Glu Leu 
    130                 135                 140                 


Ser Thr Leu Thr Leu Arg Val Thr Ser Ile Gln Ala Asp Phe Glu Ser 
145                 150                 155                 160 


Arg Ile Ser Thr Leu Glu Arg Thr Ala Val Thr Ser Ala Gly Ala Pro 
                165                 170                 175     


Leu Ser Ile Arg Asn Asn Arg Met Thr Met Gly Leu Asn Asp Gly Leu 
            180                 185                 190         


Thr Leu Ser Gly Asn Asn Leu Ala Ile Arg Leu Pro Gly Asn Thr Gly 
        195                 200                 205             


Leu Asn Ile Gln Asn Gly Gly Leu Gln Phe Arg Phe Asn Thr Asp Gln 
    210                 215                 220                 


Phe Gln Ile Val Asn Asn Asn Leu Thr Leu Lys Thr Thr Val Phe Asp 
225                 230                 235                 240 


Ser Ile Asn Ser Arg Ile Gly Ala Thr Glu Gln Ser Tyr Val Ala Ser 
                245                 250                 255     


Ala Val Thr Pro Leu Arg Leu Asn Ser Ser Thr Lys Val Leu Asp Met 
            260                 265                 270         


Leu Ile Asp Ser Ser Thr Leu Glu Ile Asn Ser Ser Gly Gln Leu Thr 
        275                 280                 285             


Val Arg Ser Thr Ser Pro Asn Leu Arg Tyr Pro Ile Ala Asp Val Ser 
    290                 295                 300                 


Gly Gly Ile Gly Met Ser Pro Asn Tyr Arg Phe Arg Gln Ser Met Trp 
305                 310                 315                 320 


Ile Gly Ile Val Ser Tyr Ser Gly Ser Gly Leu Asn Trp Arg Val Gln 
                325                 330                 335     


Val Asn Ser Asp Ile Phe Ile Val Asp Asp Tyr Ile His Ile Cys Leu 
            340                 345                 350         


Pro Ala Phe Asp Gly Phe Ser Ile Ala Asp Gly Gly Asp Leu Ser Leu 
        355                 360                 365             


Asn Phe Val Thr Gly Leu Leu Pro Pro Leu Leu Thr Gly Asp Thr Glu 
    370                 375                 380                 


Pro Ala Phe His Asn Asp Val Val Thr Tyr Gly Ala Gln Thr Val Ala 
385                 390                 395                 400 


Ile Gly Leu Ser Ser Gly Gly Ala Pro Gln Tyr Met Ser Lys Asn Leu 
                405                 410                 415     


Trp Val Glu Gln Trp Gln Asp Gly Val Leu Arg Leu Arg Val Glu Gly 
            420                 425                 430         


Gly Gly Ser Ile Thr His Ser Asn Ser Lys Trp Pro Ala Met Thr Val 
        435                 440                 445             


Ser Tyr Pro Arg Ser Phe Thr 
    450                 455 


<210>  2
<211>  462
<212>  PRT
<213>  Mammalian orthoreovirus 2

<400>  2

Met Ser Asp Leu Val Gln Leu Ile Arg Arg Glu Ile Leu Leu Leu Thr 
1               5                   10                  15      


Gly Asn Gly Glu Ser Ala Asn Ser Lys His Glu Ile Glu Glu Ile Lys 
            20                  25                  30          


Lys Gln Ile Lys Asp Ile Ser Ala Asp Val Asn Arg Ile Ser Asn Ile 
        35                  40                  45              


Val Asp Ser Ile Gln Gly Gln Leu Gly Gly Leu Ser Val Arg Val Ser 
    50                  55                  60                  


Ala Ile Glu Ser Gly Val Ser Glu Asn Gly Asn Arg Ile Asp Arg Leu 
65                  70                  75                  80  


Glu Arg Asp Val Ser Gly Ile Ser Ala Ser Val Ser Gly Ile Asp Ser 
                85                  90                  95      


Arg Leu Ser Glu Leu Gly Asp Arg Val Asn Val Ala Glu Gln Arg Ile 
            100                 105                 110         


Gly Gln Leu Asp Thr Val Thr Asp Asn Leu Leu Glu Arg Ala Ser Arg 
        115                 120                 125             


Leu Glu Thr Glu Val Ser Ala Ile Thr Asn Asp Leu Gly Ser Leu Asn 
    130                 135                 140                 


Thr Arg Val Thr Thr Glu Leu Asn Asp Val Arg Gln Thr Ile Ala Ala 
145                 150                 155                 160 


Ile Asp Thr Arg Leu Thr Thr Leu Glu Thr Asp Ala Val Thr Ser Val 
                165                 170                 175     


Gly Gln Gly Leu Gln Lys Thr Gly Asn Ser Ile Lys Val Ile Val Gly 
            180                 185                 190         


Thr Gly Met Trp Phe Asp Arg Asn Asn Val Leu Gln Leu Phe Val Ser 
        195                 200                 205             


Asn Gln Gln Lys Gly Leu Gly Phe Ile Asp Asn Gly Met Val Val Lys 
    210                 215                 220                 


Ile Asp Thr Gln Tyr Phe Ser Phe Asp Ser Asn Gly Asn Ile Thr Leu 
225                 230                 235                 240 


Asn Asn Asn Ile Ser Gly Leu Pro Ala Arg Thr Gly Ser Leu Glu Ala 
                245                 250                 255     


Ser Arg Ile Asp Val Val Ala Pro Pro Leu Val Ile Gln Ser Thr Gly 
            260                 265                 270         


Ser Thr Arg Leu Leu Arg Leu Met Tyr Glu Ala Val Asp Phe Val Val 
        275                 280                 285             


Thr Asn Asn Val Leu Thr Leu Arg Asn Arg Ser Val Thr Pro Thr Phe 
    290                 295                 300                 


Lys Phe Pro Leu Glu Leu Asn Ser Ala Asp Asn Ser Val Ser Ile His 
305                 310                 315                 320 


Arg Asn Tyr Arg Ile Arg Leu Gly Gln Trp Ser Gly Gln Leu Glu Tyr 
                325                 330                 335     


His Thr Pro Ser Leu Arg Trp Asn Ala Pro Val Thr Val Asn Leu Met 
            340                 345                 350         


Arg Val Asp Asp Trp Leu Ile Leu Ser Phe Thr Arg Phe Ser Thr Ser 
        355                 360                 365             


Gly Ile Leu Ala Ser Gly Lys Phe Val Leu Asn Phe Val Thr Gly Leu 
    370                 375                 380                 


Ser Pro Gly Trp Ala Thr Gly Ser Thr Glu Pro Ser Thr Thr Thr Asn 
385                 390                 395                 400 


Pro Leu Ser Thr Thr Phe Ala Ala Ile Gln Phe Ile Asn Gly Ser Ser 
                405                 410                 415     


Arg Val Asp Ala Phe Arg Ile Leu Gly Val Ala Glu Trp Asn Ala Gly 
            420                 425                 430         


Glu Leu Glu Ile Thr Asn Tyr Gly Gly Thr Tyr Thr Ala His Thr Asn 
        435                 440                 445             


Val Asp Trp Ala Pro Met Thr Ile Met Tyr Pro Cys Leu Gly 
    450                 455                 460         


<210>  3
<211>  470
<212>  PRT
<213>  Mammalian orthoreovirus 2

<400>  3

Met Asp Ala Ser Leu Ile Thr Glu Ile Arg Lys Ile Val Leu Gln Leu 
1               5                   10                  15      


Ser Val Ser Ser Asn Gly Ser Gln Ser Lys Glu Ile Glu Glu Ile Lys 
            20                  25                  30          


Lys Gln Val Gln Val Asn Val Asp Asp Ile Arg Ala Ala Asn Ile Lys 
        35                  40                  45              


Leu Asp Gly Leu Gly Arg Gln Ile Ala Asp Ile Ser Asn Ser Ile Ser 
    50                  55                  60                  


Thr Ile Glu Ser Arg Leu Gly Glu Met Asp Asn Arg Leu Val Gly Ile 
65                  70                  75                  80  


Ser Ser Gln Val Thr Gln Leu Ser Asn Ser Val Ser Gln Asn Thr Gln 
                85                  90                  95      


Ser Ile Ser Ser Leu Gly Asp Arg Ile Asn Ala Val Glu Pro Arg Val 
            100                 105                 110         


Asp Ser Leu Asp Thr Val Thr Ser Asn Leu Thr Gly Arg Thr Ser Thr 
        115                 120                 125             


Leu Glu Ala Asp Val Gly Ser Leu Arg Thr Glu Leu Ala Ala Leu Thr 
    130                 135                 140                 


Thr Arg Val Thr Thr Glu Val Thr Arg Leu Asp Gly Leu Ile Asn Ser 
145                 150                 155                 160 


Gly Gln Asn Ser Ile Gly Glu Leu Ser Thr Arg Leu Ser Asn Val Glu 
                165                 170                 175     


Thr Ser Met Val Thr Thr Ala Gly Arg Gly Leu Gln Lys Asn Gly Asn 
            180                 185                 190         


Thr Leu Asn Val Ile Val Gly Asn Gly Met Trp Phe Asn Ser Ser Asn 
        195                 200                 205             


Gln Leu Gln Leu Asp Leu Ser Gly Gln Ser Lys Gly Val Gly Phe Val 
    210                 215                 220                 


Gly Thr Gly Met Val Val Lys Ile Asp Thr Asn Tyr Phe Ala Tyr Asn 
225                 230                 235                 240 


Ser Asn Gly Glu Ile Thr Leu Val Ser Gln Ile Asn Glu Leu Pro Ser 
                245                 250                 255     


Arg Val Ser Thr Leu Glu Ser Ala Lys Ile Asp Ser Val Leu Pro Pro 
            260                 265                 270         


Leu Thr Val Arg Glu Ala Ser Gly Val Arg Thr Leu Ser Phe Gly Tyr 
        275                 280                 285             


Asp Thr Ser Asp Phe Thr Ile Ile Asn Ser Val Leu Ser Leu Arg Ser 
    290                 295                 300                 


Arg Leu Thr Leu Pro Thr Tyr Arg Tyr Pro Leu Glu Leu Asp Thr Ala 
305                 310                 315                 320 


Asn Asn Arg Val Gln Val Ala Asp Arg Phe Gly Met Arg Thr Gly Thr 
                325                 330                 335     


Trp Thr Gly Gln Leu Gln Tyr Gln His Pro Gln Leu Ser Trp Arg Ala 
            340                 345                 350         


Asn Val Thr Leu Asn Leu Met Lys Val Asp Asp Trp Leu Val Leu Ser 
        355                 360                 365             


Phe Ser Gln Met Thr Thr Asn Ser Ile Met Ala Asp Gly Lys Phe Val 
    370                 375                 380                 


Ile Asn Phe Val Ser Gly Leu Ser Ser Gly Trp Gln Thr Gly Asp Thr 
385                 390                 395                 400 


Glu Pro Ser Ser Thr Ile Asp Pro Trp Ser Thr Thr Phe Ala Ala Val 
                405                 410                 415     


Gln Phe Leu Asn Asn Gly Gln Arg Ile Asp Ala Phe Arg Ile Met Gly 
            420                 425                 430         


Val Ser Glu Trp Thr Asp Gly Glu Leu Glu Ile Lys Asn Tyr Gly Gly 
        435                 440                 445             


Thr Tyr Thr Gly His Thr Gln Val Tyr Trp Ala Pro Trp Thr Ile Met 
    450                 455                 460                 


Tyr Pro Cys Asn Val Arg 
465                 470 


