                              Sequence Listing

<110> GENENTECH, INC.
      CLARK,HILARY
      EATON,DANIEL L.
      FENAUX, JILL
      GONZALEZ, LINO
      GURNEY, AUSTIN L.
      LOYET, KELLY M.
      OUYANG, WENJUN
      WRANIK, BERND

<120> Novel Composition and Methods for the Treatment of 
      Immune Related Diseases

<130> P1996R1P2 WO

<150> US 11/686,135
<151> 2007-03-14

<160> 14

<210> 1
<211> 1066
<212> DNA
<213> Homo sapiens

<400> 1
 cctcggttct atcgattgaa ttcatgaaga cattgcctgc catgcttgga 50

 actgggaaat tattttgggt cttcttctta atcccatatc tggacatctg 100

 gaacatccat gggaaagaat catgtgatgt acagctttat ataaagagac 150

 aatctgaaca ctccatctta gcaggagatc cctttgaact agaatgccct 200

 gtgaaatact gtgctaacag gcctcatgtg acttggtgca agctcaatgg 250

 aacaacatgt gtaaaacttg aagatagaca aacaagttgg aaggaagaga 300

 agaacatttc atttttcatt ctacattttg aaccagtgct tcctaatgac 350

 aatgggtcat accgctgttc tgcaaatttt cagtctaatc tcattgaaag 400

 ccactcaaca actctttatg tgacagatgt aaaaagtgct tcagaacgac 450

 cctccaagga cgaaatggca agcagaccct ggctcctgta tagtttactt 500

 cctttggggg gattgcctct actcatcact acctgtttct gcctgttctg 550

 ctgcctgaga aggcaccaag gaaagcaaaa tgaactctct gacacagcag 600

 gaagggaaat taacctggtt gatgctcacc ttaagagtga gcaaacagaa 650

 gcaagcacca ggcaaaattc ccaagtactg ctatcagaaa ctggaattta 700

 tgataatgac cctgaccttt gtttcagaat gcaggaaggg tctgaagttt 750

 attctaatcc atgcctggaa gaaaacaaac caggcattgt ttatgcttcc 800

 ctgaaccatt ctgtcattgg actgaactca agactggcaa gaaatgtaaa 850

 agaagcacca acagaatatg catccatatg tgtgaggagt taaggatcct 900

 ctagagtcga cctgcagaag cttggccgcc atggcccaac ttgtttattg 950

 cagcttataa gtgttacaaa taaacaaata atatttctca atttgagaat 1000

 ttttacttta gaaatgttca tgttagtgct tgggtctgaa gggtccatag 1050

 gacaaatgat  taaaat 1066

<210> 2
<211> 289
<212> PRT
<213> Homo sapiens

<400> 2
 Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp
   1               5                  10                  15

 Val Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly
                  20                  25                  30

 Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu
                  35                  40                  45

 His Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val
                  50                  55                  60

 Lys Tyr Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn
                  65                  70                  75

 Gly Thr Thr Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys
                  80                  85                  90

 Glu Glu Lys Asn Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val
                  95                 100                 105

 Leu Pro Asn Asp Asn Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln
                 110                 115                 120

 Ser Asn Leu Ile Glu Ser His Ser Thr Thr Leu Tyr Val Thr Asp
                 125                 130                 135

 Val Lys Ser Ala Ser Glu Arg Pro Ser Lys Asp Glu Met Ala Ser
                 140                 145                 150

 Arg Pro Trp Leu Leu Tyr Ser Leu Leu Pro Leu Gly Gly Leu Pro
                 155                 160                 165

 Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys Cys Leu Arg Arg
                 170                 175                 180

 His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala Gly Arg Glu
                 185                 190                 195

 Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr Glu Ala
                 200                 205                 210

 Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly Ile
                 215                 220                 225

 Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser
                 230                 235                 240

 Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile
                 245                 250                 255

 Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Leu Asn Ser Arg
                 260                 265                 270

 Leu Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile
                 275                 280                 285

 Cys Val Arg Ser
                

<210> 3
<211> 1049
<212> DNA
<213> Homo sapiens

<400> 3
 gccgcagcaa tggcgctgag ttcctctgct ggagttcatc ctgctagctg 50

 ggttcccgag ctgccggtct gagcctgagg catggagcct cctggagact 100

 gggggcctcc tccctggaga tccaccccca gaaccgacgt cttgaggctg 150

 gtgctgtatc tcaccttcct gggagccccc tgctacgccc cagctctgcc 200

 gtcctgcaag gaggacgagt acccagtggg ctccgagtgc tgccccaagt 250

 gcagtccagg ttatcgtgtg aaggaggcct gcggggagct gacgggcaca 300

 gtgtgtgaac cctgccctcc aggcacctac attgcccacc tcaatggcct 350

 aagcaagtgt ctgcagtgcc aaatgtgtga cccagccatg ggcctgcgcg 400

 cgagccggaa ctgctccagg acagagaacg ccgtgtgtgg ctgcagccca 450

 ggccacttct gcatcgtcca ggacggggac cactgcgccg cgtgccgcgc 500

 ttacgccacc tccagcccgg gccagagggt gcagaaggga ggcaccgaga 550

 gtcaggacac cctgtgtcag aactgccccc cggggacctt ctctcccaat 600

 gggaccctgg aggaatgtca gcaccagacc aagtgcagct ggctggtgac 650

 gaaggccgga gctgggacca gcagctccca ctgggtatgg tggtttctct 700

 cagggagcct cgtcatcgtc attgtttgct ccacagttgg cctaatcata 750

 tgtgtgaaaa gaagaaagcc aaggggtgat gtagtcaagg tgatcgtctc 800

 cgtccagcgg aaaagacagg aggcagaagg tgaggccaca gtcattgagg 850

 ccctgcaggc ccctccggac gtcaccacgg tggccgtgga ggagacaata 900

 ccctcattca cggggaggag cccaaaccac tgacccacag actctgcacc 950

 ccgacgccag agatacctgg agcgacggct gctgaaagag gctgtccacc 1000

 tggcgaaacc accggagccc ggaggcttgg gggctccgcc  ctgggctgg 1049

<210> 4
<211> 283
<212> PRT
<213> Homo sapiens

<400> 4
 Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr
   1               5                  10                  15

 Pro Arg Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu
                  20                  25                  30

 Gly Ala Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp
                  35                  40                  45

 Glu Tyr Pro Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly
                  50                  55                  60

 Tyr Arg Val Lys Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys
                  65                  70                  75

 Glu Pro Cys Pro Pro Gly Thr Tyr Ile Ala His Leu Asn Gly Leu
                  80                  85                  90

 Ser Lys Cys Leu Gln Cys Gln Met Cys Asp Pro Ala Met Gly Leu
                  95                 100                 105

 Arg Ala Ser Arg Asn Cys Ser Arg Thr Glu Asn Ala Val Cys Gly
                 110                 115                 120

 Cys Ser Pro Gly His Phe Cys Ile Val Gln Asp Gly Asp His Cys
                 125                 130                 135

 Ala Ala Cys Arg Ala Tyr Ala Thr Ser Ser Pro Gly Gln Arg Val
                 140                 145                 150

 Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr Leu Cys Gln Asn Cys
                 155                 160                 165

 Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu Glu Glu Cys Gln
                 170                 175                 180

 His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala Gly Ala Gly
                 185                 190                 195

 Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly Ser Leu
                 200                 205                 210

 Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys Val
                 215                 220                 225

 Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser
                 230                 235                 240

 Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile
                 245                 250                 255

 Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu
                 260                 265                 270

 Glu Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His
                 275                 280            

<210> 5
<211> 1159
<212> DNA
<213> Homo sapiens

<400> 5
 ggtttcctct gaggttgaag gacccaggcg tgtcagccct gctccagaca 50

 ccttgggcat ggaggagagt gtcgtacggc cctcagtgtt tgtggtggat 100

 ggacagaccg acatcccatt cacgaggctg ggacgaagcc accggagaca 150

 gtcgtgcagt gtggcccggg tgggtctggg tctcttgctg ttgctgatgg 200

 gggccgggct ggccgtccaa ggctggttcc tcctgcagct gcactggcgt 250

 ctaggagaga tggtcacccg cctgcctgac ggacctgcag gctcctggga 300

 gcagctgata caagagcgaa ggtctcacga ggtcaaccca gcagcgcatc 350

 tcacaggggc caactccagc ttgaccggca gcggggggcc gctgttatgg 400

 gagactcagc tgggcctggc cttcctgagg ggcctcagct accacgatgg 450

 ggcccttgtg gtcaccaaag ctggctacta ctacatctac tccaaggtgc 500

 agctgggcgg tgtgggctgc ccgctgggcc tggccagcac catcacccac 550

 ggcctctaca agcgcacacc ccgctacccc gaggagctgg agctgttggt 600

 cagccagcag tcaccctgcg gacgggccac cagcagctcc cgggtctggt 650

 gggacagcag cttcctgggt ggtgtggtac acctggaggc tggggaggag 700

 gtggtcgtcc gtgtgctgga tgaacgcctg gttcgactgc gtgatggtac 750

 ccggtcttac ttcggggctt tcatggtgtg aaggaaggag cgtggtgcat 800

 tggacatggg tctgacacgt ggagaactca gagggtgcct caggggaaag 850

 aaaactcacg aagcagaggc tgggcgtggt ggctctcgcc tgtaatccca 900

 gcactttggg aggccaaggc aggcggatca cctgaggtca ggagttcgag 950

 accagcctgg ctaacatggc aaaaccccat ctctactaaa aatacaaaaa 1000

 ttagccggac gtggtggtgc ctgcctgtaa tccagctact caggaggctg 1050

 aggcaggata attttgctta aacccgggag gcggaggttg cagtgagccg 1100

 agatcacacc actgcactcc aacctgggaa acgcagtgag actgtgcctc 1150

 aaaaaaaag 1159

<210> 6
<211> 240
<212> PRT
<213> Homo sapiens

<400> 6
 Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly
   1               5                  10                  15

 Gln Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg
                  20                  25                  30

 Gln Ser Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu
                  35                  40                  45

 Leu Met Gly Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln
                  50                  55                  60

 Leu His Trp Arg Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly
                  65                  70                  75

 Pro Ala Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg Arg Ser His
                  80                  85                  90

 Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu
                  95                 100                 105

 Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu
                 110                 115                 120

 Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val
                 125                 130                 135

 Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly
                 140                 145                 150

 Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly
                 155                 160                 165

 Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu
                 170                 175                 180

 Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg
                 185                 190                 195

 Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu
                 200                 205                 210

 Ala Gly Glu Glu Val Val Val Arg Val Leu Asp Glu Arg Leu Val
                 215                 220                 225

 Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val
                 230                 235                 240

<210> 7
<211> 726
<212> DNA
<213> Homo sapiens

<400> 7
 atgaagacat tgcctgccat gcttggaact gggaaattat tttgggtctt 50

 cttcttaatc ccatatctgg acatctggaa catccatggg aaagaatcat 100

 gtgatgtaca gctttatata aagagacaat ctgaacactc catcttagca 150

 ggagatccct ttgaactaga atgccctgtg aaatactgtg ctaacaggcc 200

 tcatgtgact tggtgcaagc tcaatggaac aacatgtgta aaacttgaag 250

 atagacaaac aagttggaag gaagagaaga acatttcatt tttcattcta 300

 cattttgaac cagtgcttcc taatgacaat gggtcatacc gctgttctgc 350

 aaattttcag tctaatctca ttgaaagcca ctcaacaact ctttatgtga 400

 caggaaagca aaatgaactc tctgacacag caggaaggga aattaacctg 450

 gttgatgctc accttaagag tgagcaaaca gaagcaagca ccaggcaaaa 500

 ttcccaagta ctgctatcag aaactggaat ttatgataat gaccctgacc 550

 tttgtttcag gatgcaggaa gggtctgaag tttattctaa tccatgcctg 600

 gaagaaaaca aaccaggcat tgtttatgct tccctgaacc attctgtcat 650

 tggactgaac tcaagactgg caagaaatgt aaaagaagca ccaacagaat 700

 atgcatccat atgtgtgagg  agttaa 726

<210> 8
<211> 241
<212> PRT
<213> Homo sapiens

<400> 8
 Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp
   1               5                  10                  15

 Val Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly
                  20                  25                  30

 Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu
                  35                  40                  45

 His Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val
                  50                  55                  60

 Lys Tyr Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn
                  65                  70                  75

 Gly Thr Thr Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys
                  80                  85                  90

 Glu Glu Lys Asn Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val
                  95                 100                 105

 Leu Pro Asn Asp Asn Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln
                 110                 115                 120

 Ser Asn Leu Ile Glu Ser His Ser Thr Thr Leu Tyr Val Thr Gly
                 125                 130                 135

 Lys Gln Asn Glu Leu Ser Asp Thr Ala Gly Arg Glu Ile Asn Leu
                 140                 145                 150

 Val Asp Ala His Leu Lys Ser Glu Gln Thr Glu Ala Ser Thr Arg
                 155                 160                 165

 Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly Ile Tyr Asp Asn
                 170                 175                 180

 Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser Glu Val Tyr
                 185                 190                 195

 Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val Tyr Ala
                 200                 205                 210

 Ser Leu Asn His Ser Val Ile Gly Leu Asn Ser Arg Leu Ala Arg
                 215                 220                 225

 Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg
                 230                 235                 240

 Ser
    

<210> 9
<211> 888
<212> DNA
<213> Homo sapiens

<400> 9
 atgaagacat tgcctgccat gcttggaact gggaaattat tttgggtctt 50

 cttcttaatc ccatatctgg acatctggaa catccatggg aaagaatcat 100

 gtgatgtaca gctttatata aagagacaat ctgaacactc catcttagca 150

 ggagatccct ttgaactaga atgccctgtg aaatactgtg ctaacaggcc 200

 tcatgtgact tggtgcaagc tcaatggaac aacatgtgta aaacttgaag 250

 atagacaaac aagttggaag gaagagaaga acatttcatt tttcattcta 300

 cattttgaac cagtgcttcc taatgacaat gggtcatacc gctgttctgc 350

 aaattttcag tctaatctca ttgaaagcca ctcaacaact ctttatgtga 400

 cagcatttac taacattcca gatgtaaaaa gtgcctcaga acgaccctcc 450

 aaggacgaaa tggcaagcag accctggctc ctgtatagtt tacttccttt 500

 ggggggattg cctctactca tcactacctg tttctgcctg ttctgctgcc 550

 tgagaaggca ccaaggaaag caaaatgaac tctctgacac agcaggaagg 600

 gaaattaacc tggttgatgc tcaccttaag agtgagcaaa cagaagcaag 650

 caccaggcaa aattcccaag tactgctatc agaaactgga atttatgata 700

 atgaccctga cctttgtttc aggatgcagg aagggtctga agtttattct 750

 aatccatgcc tggaagaaaa caaaccaggc attgtttatg cttccctgaa 800

 ccattctgtc attggactga actcaagact ggcaagaaat gtaaaagaag 850

 caccaacaga atatgcatcc atatgtgtga  ggagttaa 888

<210> 10
<211> 295
<212> PRT
<213> Homo sapiens

<400> 10
 Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp
   1               5                  10                  15

 Val Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly
                  20                  25                  30

 Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu
                  35                  40                  45

 His Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val
                  50                  55                  60

 Lys Tyr Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn
                  65                  70                  75

 Gly Thr Thr Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys
                  80                  85                  90

 Glu Glu Lys Asn Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val
                  95                 100                 105

 Leu Pro Asn Asp Asn Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln
                 110                 115                 120

 Ser Asn Leu Ile Glu Ser His Ser Thr Thr Leu Tyr Val Thr Ala
                 125                 130                 135

 Phe Thr Asn Ile Pro Asp Val Lys Ser Ala Ser Glu Arg Pro Ser
                 140                 145                 150

 Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Ser Leu Leu
                 155                 160                 165

 Pro Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu
                 170                 175                 180

 Phe Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser
                 185                 190                 195

 Asp Thr Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys
                 200                 205                 210

 Ser Glu Gln Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu
                 215                 220                 225

 Leu Ser Glu Thr Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe
                 230                 235                 240

 Arg Met Gln Glu Gly Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu
                 245                 250                 255

 Glu Asn Lys Pro Gly Ile Val Tyr Ala Ser Leu Asn His Ser Val
                 260                 265                 270

 Ile Gly Leu Asn Ser Arg Leu Ala Arg Asn Val Lys Glu Ala Pro
                 275                 280                 285

 Thr Glu Tyr Ala Ser Ile Cys Val Arg Ser
                 290                 295

<210> 11
<211> 30
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic oligonucleotide

<400> 11
 ttgaattcat gaagacattg cctgccatgc 30

<210> 12
<211> 38
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic oligonucleotide

<400> 12
 ttggatcctt aactcctcac acatatggat  gcatattc 38

<210> 13
<211> 946
<212> DNA
<213> Mus musculus

<400> 13
 gctggaatga agacagtgcc tgccatgctt gggactcctc ggttatttag 50

 ggaattcttc atcctccatc tgggcctctg gagcatcctt tgtgagaaag 100

 ctactaagag gaatgatgaa gagtgtgaag tgcaacttaa tattaagagg 150

 aattccaaac actctgcctg gacaggagag ctatttaaaa ttgaatgtcc 200

 tgtgaaatac tgtgttcata gacctcatgt gacttggtgt aagcacaatg 250

 gaacaatctg ggtacccctt gaagtcggtc ctcagctata cactagttgg 300

 gaagaaaatc gatcagttcc ggtttttgtt ctccatttta aaccaataca 350

 tctcagtgat aacgggtcgt atagctgttc tacaaacttc aattctcaag 400

 ttattaatag ccattcagta accatccatg tgagagaaag gactcaaaac 450

 tcttcagaac acccactaat aatatctgac atcccagatg ccaccaatgc 500

 ctcaggacca tccaccatgg aagagaggcc aggcaggact tggctgcttt 550

 acaccttgct tcctttgggg gcattgcttc tgctccttgc ctgtgtctgc 600

 ctgctctgct ttctgaaaag gatccaaggg aaagaaaaga agccttctga 650

 cttggcagga agggacacta acctggttga tattccagcc agttccagga 700

 caaatcacca agcactgcca tcaggaactg gaatttatga taatgatccc 750

 tggtctagca tgcaggatga atctgaattg acaattagct tgcaatcaga 800

 gagaaacaac cagggcattg tttatgcttc tttgaaccat tgtgttattg 850

 gaaggaatcc aagacaggaa aacaacatgc aggaggcacc cacagaatat 900

 gcatccattt gtgtgagaag ttaaacctgc cactgtctag  agcggg 946

<210> 14
<211> 305
<212> PRT
<213> Mus musculus

<400> 14
 Met Lys Thr Val Pro Ala Met Leu Gly Thr Pro Arg Leu Phe Arg
   1               5                  10                  15

 Glu Phe Phe Ile Leu His Leu Gly Leu Trp Ser Ile Leu Cys Glu
                  20                  25                  30

 Lys Ala Thr Lys Arg Asn Asp Glu Glu Cys Glu Val Gln Leu Asn
                  35                  40                  45

 Ile Lys Arg Asn Ser Lys His Ser Ala Trp Thr Gly Glu Leu Phe
                  50                  55                  60

 Lys Ile Glu Cys Pro Val Lys Tyr Cys Val His Arg Pro His Val
                  65                  70                  75

 Thr Trp Cys Lys His Asn Gly Thr Ile Trp Val Pro Leu Glu Val
                  80                  85                  90

 Gly Pro Gln Leu Tyr Thr Ser Trp Glu Glu Asn Arg Ser Val Pro
                  95                 100                 105

 Val Phe Val Leu His Phe Lys Pro Ile His Leu Ser Asp Asn Gly
                 110                 115                 120

 Ser Tyr Ser Cys Ser Thr Asn Phe Asn Ser Gln Val Ile Asn Ser
                 125                 130                 135

 His Ser Val Thr Ile His Val Arg Glu Arg Thr Gln Asn Ser Ser
                 140                 145                 150

 Glu His Pro Leu Ile Ile Ser Asp Ile Pro Asp Ala Thr Asn Ala
                 155                 160                 165

 Ser Gly Pro Ser Thr Met Glu Glu Arg Pro Gly Arg Thr Trp Leu
                 170                 175                 180

 Leu Tyr Thr Leu Leu Pro Leu Gly Ala Leu Leu Leu Leu Leu Ala
                 185                 190                 195

 Cys Val Cys Leu Leu Cys Phe Leu Lys Arg Ile Gln Gly Lys Glu
                 200                 205                 210

 Lys Lys Pro Ser Asp Leu Ala Gly Arg Asp Thr Asn Leu Val Asp
                 215                 220                 225

 Ile Pro Ala Ser Ser Arg Thr Asn His Gln Ala Leu Pro Ser Gly
                 230                 235                 240

 Thr Gly Ile Tyr Asp Asn Asp Pro Trp Ser Ser Met Gln Asp Glu
                 245                 250                 255

 Ser Glu Leu Thr Ile Ser Leu Gln Ser Glu Arg Asn Asn Gln Gly
                 260                 265                 270

 Ile Val Tyr Ala Ser Leu Asn His Cys Val Ile Gly Arg Asn Pro
                 275                 280                 285

 Arg Gln Glu Asn Asn Met Gln Glu Ala Pro Thr Glu Tyr Ala Ser
                 290                 295                 300

 Ile Cys Val Arg Ser
                 305

