                         SEQUENCE LISTING

<110>  CEDARS-SINAI MEDICAL CENTER
       ROTTER, Jerome I.
       TAYLOR, Kent D.
       DUBINSKY, Marla
       TARGAN, Stephan R.
 
<120>   METHODS OF USING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE TL1A 
       GENE TO PREDICT OR DIAGNOSE INFLAMMATORY BOWEL DISEASE

<130>  67789-978

<150>  60/891,578
<151>  2007-02-26

<160>  17    

<170>  PatentIn version 3.4

<210>  1
<211>  2011
<212>  DNA
<213>  Homo sapiens

<400>  1
ggaaaaggga aggaggagac tgagtgatta agtcacccac tgtgagagct ggtcttctat     60

ttaatggggg ctctctctgc ccaggagtca gaggtgcctc caggagcagc aggagcatgg    120

ccgaggatct gggactgagc tttggggaaa cagccagtgt ggaaatgctg ccagagcacg    180

gcagctgcag gcccaaggcc aggagcagca gcgcacgctg ggctctcacc tgctgcctgg    240

tgttgctccc cttccttgca ggactcacca catacctgct tgtcagccag ctccgggccc    300

agggagaggc ctgtgtgcag ttccaggctc taaaaggaca ggagtttgca ccttcacatc    360

agcaagttta tgcacctctt agagcagacg gagataagcc aagggcacac ctgacagttg    420

tgagacaaac tcccacacag cactttaaaa atcagttccc agctctgcac tgggaacatg    480

aactaggcct ggccttcacc aagaaccgaa tgaactatac caacaaattc ctgctgatcc    540

cagagtcggg agactacttc atttactccc aggtcacatt ccgtgggatg acctctgagt    600

gcagtgaaat cagacaagca ggccgaccaa acaagccaga ctccatcact gtggtcatca    660

ccaaggtaac agacagctac cctgagccaa cccagctcct catggggacc aagtctgtat    720

gcgaagtagg tagcaactgg ttccagccca tctacctcgg agccatgttc tccttgcaag    780

aaggggacaa gctaatggtg aacgtcagtg acatctcttt ggtggattac acaaaagaag    840

ataaaacctt ctttggagcc ttcttactat aggaggagag caaatatcat tatatgaaag    900

tcctctgcca ccgagttcct aattttcttt gttcaaatgt aattataacc aggggttttc    960

ttggggccgg gagtaggggg cattccacag ggacaacggt ttagctatga aatttggggc   1020

ccaaaatttc acacttcatg tgccttactg atgagagtac taactggaaa aaggctgaag   1080

agagcaaata tattattaag atgggttgga ggattggcga gtttctaaat attaagacac   1140

tgatcactaa atgaatggat gatctactcg ggtcaggatt gaaagagaaa tatttcaaca   1200

ccttcctgct atacaatggt caccagtggt ccagttattg ttcaatttga tcataaattt   1260

gcttcaattc aggagctttg aaggaagtcc aaggaaagct ctagaaaaca gtataaactt   1320

tcagaggcaa aatccttcac caatttttcc acatactttc atgccttgcc taaaaaaaat   1380

gaaaagagag ttggtatgtc tcatgaatgt tcacacagaa ggagttggtt ttcatgtcat   1440

ctacagcata tgagaaaagc tacctttctt ttgattatgt acacagatat ctaaataagg   1500

aagtatgagt ttcacatgta tatcaaaaat acaacagttg cttgtattca gtagagtttt   1560

cttgcccacc tattttgtgc tgggttctac cttaacccag aagacactat gaaaaacaag   1620

acagactcca ctcaaaattt atatgaacac cactagatac ttcctgatca aacatcagtc   1680

aacatactct aaagaataac tccaagtctt ggccaggcgc agtggctcac acctgtaatc   1740

ccaacacttt gggaggccaa ggtgggtgga tcatctaagg ccgggagttc aagaccagcc   1800

tgaccaacgt ggagaaaccc catctctact aaaaatacaa aattagccgg gcgtggtagc   1860

gcatggctgt aatcctggct actcaggagg ccgaggcaga agaattgctt gaactgggga   1920

ggcagaggtt gcggtgagcc cagatcgcgc cattgcactc cagcctgggt aacaagagca   1980

aaactctgtc caaaaaaaaa aaaaaaaaaa a                                  2011


<210>  2
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 
1               5                   10                  15      


Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 
            20                  25                  30          


Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 
        35                  40                  45              


Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 
    50                  55                  60                  


Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
65                  70                  75                  80  


His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
                85                  90                  95      


Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            100                 105                 110         


Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        115                 120                 125             


Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    130                 135                 140                 


Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
145                 150                 155                 160 


Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                165                 170                 175     


Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            180                 185                 190         


Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        195                 200                 205             


Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    210                 215                 220                 


Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
225                 230                 235                 240 


Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250     


<210>  3
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  3
ccccaaattt catagctaaa ccgttgtccc tgtggaatgc cccctactcc cggccccaag     60

aaaacccctg gttataatta catttgaaca aagaaaatta ggaactcggt ggcagaggac    120

tttcatataa tgatatttgc tctcctccta tagtaagaag gctccaaaga aggttttatc    180

ttcttttgtg taatccacca aagagatgtc actgacgttc accattagct tgtccccttc    240

ttgcaaggag aacatggctc cgaggtagat gggctggaac cagttgctac ctacttcgca    300

yacagacttg gtccccatga ggagctgggt tggctcaggg tagctgtctg ttaccttggt    360

gatgaccaca gtgatggagt ctggcttgtt tggtcggcct gcttgtctga tttcactgca    420

ctcagaggtc atcccacgga atgtgacctg ggagtaaatg aagtagtctc ccgactctgg    480

gatcagcagg aatttgttgg tatagttcat tcggttcttg gtgaaggcca ggcctagttc    540

atgttcccag tgcagagctg ggaactgatt tttaaagtgc tgtgtgggag tttgtctcac    600

a                                                                    601


<210>  4
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  4
tcttctgcaa aaccaagggc tgtcatttct attttgcaat tttctcatgg tgtttcaatt     60

ccaggccttg gcatgctgct ctcctggatt ctttcatcag cccctggcag ggtctttgta    120

cttcagtttt ctccttttcc ttgatctatt tcctggcctg ccttcagagg gctttttcta    180

aagcatcact ttatctagat actacactgc ttataaacct tcaatggctc ctcatggctc    240

ttaagaccca gtccaatctc attttgtctt ggcattcaaa gtcctaactt atcccagtct    300

ygctatccat tatttacttc tctctaagcc ctctgtgttc ccagccatga gaggcaacca    360

ctgtgaattg attcaaggta tctgaagaaa cagagttaag tgtagttact ttattgaatt    420

agtagggaca cagagacctg gcccagaaat gggagaatca gaagaaattg ctcctgaaca    480

gagtcttaga ggtcctgcag gtactagcca ggtgataaaa gaggtaatga ctattccaga    540

caaggccaac agcttgcaca acagcaaata cctcaatacc ctgcatctgt gatgtggtgt    600

c                                                                    601


<210>  5
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  5
cctacaacag aaaccaagtt tggtttgagg aaaaaaaaaa aaaaaaaaaa aagaagaaga     60

aggagaagaa gaaagctttc ccaagcatat ttatatacag tatgctcatg tgctccttcc    120

ttcgtttaca gaaggaagtt aggaaagtcc ctgaaggagg agagaaagaa ttcatcaagt    180

cagtgggtgg ggcaaattaa aatatacctg ttccctgcac tggaggctta ccagctgtgc    240

cagtctgggg agtgtgcttc tggaagtgaa agtgagggat gagaggtgtg tggtttgcag    300

rttgggaaac ggaaatcaca tttgcatcag ctctttgcaa agtgctgcct agccctctgt    360

cattttgaac ctcatagaaa ttcattctca gtgtacagat gggaatagca aagttctaaa    420

aggtgaaggc acttgtccta ggtcatccaa ggatgaagac agaggagcta ggaagatgac    480

ctagttctaa atcacggctt ggagttgtaa cctctagcac atgactgccc atgaaaggaa    540

agtatttcca gtctgcattg accattgttt aatcagagta tgaggccaca gatcgaggtg    600

a                                                                    601


<210>  6
<211>  682
<212>  DNA
<213>  Homo sapiens

<400>  6
atgagaggtg tgtggtttgc agattgggaa acggaaatca catttgcatc agctctttgc     60

aaagtgctgc ctagccctct gtcattttga acctcataga aattcattct cagtgtacag    120

atgggaatag caaagttcta aaaggtgaag gcacttgtcc taggtcatcc aaggatgaag    180

acagaggagc taggaagatg acctagttct aaatcacggc ttggagttgt aacctctagc    240

acatgactgc ccatgaaagg aaagtatttc cagtctgcat tgaccattgt ttaatcagag    300

taygaggcca cagatcgagg tgactgtctg tgagggtaga acattaacca ctactccctg    360

attagtctaa agttaattga tcatgtgatg tgctttgcct gcagttgggt gtgggggcca    420

caacatgtaa taaaagatta tatttattaa gtgcttactt tgtgccaatc actgctctaa    480

gttaaataca tcaataaaat tattcaatcc tgagataaat tttgtgacaa taaagctatc    540

attctcattt tacacataag aaaataaagc acagacggca agtggtagag ccaggattgg    600

gactcaggca ggctggctgc tggcttcttc accatcacac ttcaccatag gtactgctgg    660

atcatgcatg ttcataaata cc                                             682


<210>  7
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  7
aatgtctttg tatcagaagg aaactgtctg aaggtcagcc ccctctccac tcctgaaaag     60

gcataattca gagttggcat ttttagtttt gcttttctat ttccaaatat gaaacagaca    120

aggagtcagg agacccatca cgaacttgct atgtgacttc aggctgttca ctcccctgtc    180

tctggtctcc aggaaaacaa gagggctgag aatccaccca gatccatggt ttttgtgtat    240

ctggggagtg ggctattcca ttgaaatgtg tgttttgatg atcatggcta agtgggactt    300

yagtgactca aaccctgtgt tcagatgaag cctgctcaga tttctcctat aagcgtagaa    360

gaaatgaggg ttttggaggc ccaggctggg gtctcactgg acagtcttga gaggtgggag    420

tgaatgtgaa ctctggagca cattggtttc cacgtgtccc tctgttgtgt aaccccaggc    480

aaatcatgga gcctccttag gcctcagagt cctcatggac tacaacagga tgacagaact    540

acttgttatg aagaataagt gacatgatgc tcataaagtc ctgggtacat tctgtaattc    600

a                                                                    601


<210>  8
<211>  4485
<212>  DNA
<213>  Homo sapiens

<400>  8
gtagacagat ccaggctcac cagtcctgtg ccactgggct tttggcgttc tgcacaaggc     60

ctacccgcag atgccatgcc tgctccccca gcctaatggg ctttgatggg ggaagagggt    120

ggttcagcct ctcacgatga ggaggaaaga gcaagtgtcc tcctcggaca ttctccgggt    180

tgtgaaatgt gctcgcagga ggcttttcag gcacagagga gccagctggt cgagctgctg    240

gtctcagggt ccctggaagg cttcgagagt gtcctggact ggctgctgtc ctgggaggtc    300

ctctcctggg aggactacga gggcttccac ctcctgggcc agcctctctc ccacttggcc    360

aggcgccttc tggacaccgt ctggaataag ggtacttggg cctgtcagaa gctcatcgcg    420

gctgcccaag aagcccaggc cgacagccag tcccccaagc tgcatggctg ctgggacccc    480

cactcgctcc acccagcccg agacctgcag agtcaccggc cagccattgt caggaggctc    540

cacagccatg tggagaacat gctggacctg gcatgggagc ggggtttcgt cagccagtat    600

gaatgtgatg aaatcaggtt gccgatcttc acaccgtccc agagggcaag aaggctgctt    660

gatcttgcca cggtgaaagc gaatggattg gctgccttcc ttctacaaca tgttcaggaa    720

ttaccagtcc cattggccct gcctttggaa gctgccacat gcaagaagta tatggccaag    780

ctgaggacca cggtgtctgc tcagtctcgc ttcctcagta cctatgatgg agcagagacg    840

ctctgcctgg aggacatata cacagagaat gtcctggagg tctgggcaga tgtgggcatg    900

gctggacccc cgcagaagag cccagccacc ctgggcctgg aggagctctt cagcacccct    960

ggccacctca atgacgatgc ggacactgtg ctggtggtgg gtgaggcggg cagtggcaag   1020

agcacgctcc tgcagcggct gcacttgctg tgggctgcag ggcaagactt ccaggaattt   1080

ctctttgtct tcccattcag ctgccggcag ctgcagtgca tggccaaacc actctctgtg   1140

cggactctac tctttgagca ctgctgttgg cctgatgttg gtcaagaaga catcttccag   1200

ttactccttg accaccctga ccgtgtcctg ttaacctttg atggctttga cgagttcaag   1260

ttcaggttca cggatcgtga acgccactgc tccccgaccg accccacctc tgtccagacc   1320

ctgctcttca accttctgca gggcaacctg ctgaagaatg cccgcaaggt ggtgaccagc   1380

cgtccggccg ctgtgtcggc gttcctcagg aagtacatcc gcaccgagtt caacctcaag   1440

ggcttctctg aacagggcat cgagctgtac ctgaggaagc gccatcatga gcccggggtg   1500

gcggaccgcc tcatccgcct gctccaagag acctcagccc tgcacggttt gtgccacctg   1560

cctgtcttct catggatggt gtccaaatgc caccaggaac tgttgctgca ggaggggggg   1620

tccccaaaga ccactacaga tatgtacctg ctgattctgc agcattttct gctgcatgcc   1680

acccccccag actcagcttc ccaaggtctg ggacccagtc ttcttcgggg ccgcctcccc   1740

accctcctgc acctgggcag actggctctg tggggcctgg gcatgtgctg ctacgtgttc   1800

tcagcccagc agctccaggc agcacaggtc agccctgatg acatttctct tggcttcctg   1860

gtgcgtgcca aaggtgtcgt gccagggagt acggcgcccc tggaattcct tcacatcact   1920

ttccagtgct tctttgccgc gttctacctg gcactcagtg ctgatgtgcc accagctttg   1980

ctcagacacc tcttcaattg tggcaggcca ggcaactcac caatggccag gctcctgccc   2040

acgatgtgca tccaggcctc ggagggaaag gacagcagcg tggcagcttt gctgcagaag   2100

gccgagccgc acaaccttca gatcacagca gccttcctgg cagggctgtt gtcccgggag   2160

cactggggcc tgctggctga gtgccagaca tctgagaagg ccctgctccg gcgccaggcc   2220

tgtgcccgct ggtgtctggc ccgcagcctc cgcaagcact tccactccat cccgccagct   2280

gcaccgggtg aggccaagag cgtgcatgcc atgcccgggt tcatctggct catccggagc   2340

ctgtacgaga tgcaggagga gcggctggct cggaaggctg cacgtggcct gaatgttggg   2400

cacctcaagt tgacattttg cagtgtgggc cccactgagt gtgctgccct ggcctttgtg   2460

ctgcagcacc tccggcggcc cgtggccctg cagctggact acaactctgt gggtgacatt   2520

ggcgtggagc agctgctgcc ttgccttggt gtctgcaagg ctctgtattt gcgcgataac   2580

aatatctcag accgaggcat ctgcaagctc attgaatgtg ctcttcactg cgagcaattg   2640

cagaagttag ctctattcaa caacaaattg actgacggct gtgcacactc catggctaag   2700

ctccttgcat gcaggcagaa cttcttggca ttgaggctgg ggaataacta catcactgcc   2760

gcgggagccc aagtgctggc cgaggggctc cgaggcaaca cctccttgca gttcctggga   2820

ttctggggca acagagtggg tgacgagggg gcccaggccc tggctgaagc cttgggtgat   2880

caccagagct tgaggtggct cagcctggtg gggaacaaca ttggcagtgt gggtgcccaa   2940

gccttggcac tgatgctggc aaagaacgtc atgctagaag aactctgcct ggaggagaac   3000

catctccagg atgaaggtgt atgttctctc gcagaaggac tgaagaaaaa ttcaagtttg   3060

aaaatcctga agttgtccaa taactgcatc acctacctag gggcagaagc cctcctgcag   3120

gcccttgaaa ggaatgacac catcctggaa gtctggctcc gagggaacac tttctctcta   3180

gaggaggttg acaagctcgg ctgcagggac accagactct tgctttgaag tctccgggag   3240

gatgttcgtc tcagtttgtt tgtgagcagg ctgtgagttt gggccccaga ggctgggtga   3300

catgtgttgg cagcctcttc aaaatgagcc ctgtcctgcc taaggctgaa cttgttttct   3360

gggaacacca taggtcacct ttattctggc agaggaggga gcatcagtgc cctccaggat   3420

agacttttcc caagcctact tttgccattg acttcttccc aagattcaat cccaggatgt   3480

acaaggacag cccctcctcc atagtatggg actggcctct gctgatcctc ccaggcttcc   3540

gtgtgggtca gtggggccca tggatgtgct tgttaactga gtgccttttg gtggagaggc   3600

ccggcctctc acaaaagacc ccttaccact gctctgatga agaggagtac acagaacaca   3660

taattcagga agcagctttc cccatgtctc gactcatcca tccaggccat tccccgtctc   3720

tggttcctcc cctcctcctg gactcctgca cacgctcctt cctctgaggc tgaaattcag   3780

aatattagtg acctcagctt tgatatttca cttacagcac ccccaaccct ggcacccagg   3840

gtgggaaggg ctacacctta gcctgccctc ctttccggtg tttaagacat ttttggaagg   3900

ggacacgtga cagccgtttg ttccccaaga cattctaggt ttgcaagaaa aatatgacca   3960

cactccagct gggatcacat gtggactttt atttccagtg aaatcagtta ctcttcagtt   4020

aagcctttgg aaacagctcg actttaaaaa gctccaaatg cagctttaaa aaattaatct   4080

gggccagaat ttcaaacggc ctcactaggc ttctggttga tgcctgtgaa ctgaactctg   4140

acaacagact tctgaaatag acccacaaga ggcagttcca tttcatttgt gccagaatgc   4200

tttaggatgt acagttatgg attgaaagtt tacaggaaaa aaaattaggc cgttccttca   4260

aagcaaatgt cttcctggat tattcaaaat gatgtatgtt gaagcctttg taaattgtca   4320

gatgctgtgc aaatgttatt attttaaaca ttatgatgtg tgaaaactgg ttaatattta   4380

taggtcactt tgttttactg tcttaagttt atactcttat agacaacatg gccgtgaact   4440

ttatgctgta aataatcaga ggggaataaa ctgttgagtc aaaac                   4485


<210>  9
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  9
cttcacatca ctttccagtg cttctttgcc gcgttctacc tggcactcag tgctgatgtg     60

ccaccagctt tgctcagaca cctcttcaat tgtggcaggc caggcaactc accaatggcc    120

aggctcctgc ccacgatgtg catccaggcc tcggagggaa aggacagcag cgtggcagct    180

ttgctgcaga aggccgagcc gcacaacctt cagatcacag cagccttcct ggcagggctg    240

ttgtcccggg agcactgggg cctgctggct gagtgccaga catctgagaa ggccctgctc    300

yggcgccagg cctgtgcccg ctggtgtctg gcccgcagcc tccgcaagca cttccactcc    360

atcccgccag ctgcaccggg tgaggccaag agcgtgcatg ccatgcccgg gttcatctgg    420

ctcatccgga gcctgtacga gatgcaggag gagcggctgg ctcggaaggc tgcacgtggc    480

ctgaatgttg ggcacctcaa gttgacattt tgcagtgtgg gccccactga gtgtgctgcc    540

ctggcctttg tgctgcagca cctccggcgg cccgtggccc tgcagctgga ctacaactct    600

g                                                                    601


<210>  10
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  10
ctcttgtcag tgagttcctg tccttaaggg ttagggctgg gtagccctct actattctct     60

aagtctgtaa tgtaaagcca ctgaaaactc ttgggttaag tttggccatc ccacccaaaa    120

gatggaggca ggtccacttt gctgggacca ggagccccag tgaggccact ctgggattga    180

gtggtcctgc ccctctggct gggactgcag agggaggagg actgttagtt catgtctaga    240

acacatatca ggtactcact gacactgtct gttgactctt ttggcctttt cagattctgg    300

sgcaacagag tgggtgacga gggggcccag gccctggctg aagccttggg tgatcaccag    360

agcttgaggt ggctcaggta agcttcagag tctatcctgc agttttcttg gggagatcag    420

gtgaagaggg aggagctggg gccagttctg aaggtctttg aactttattt ctaccccaca    480

atgttaggca atggagtaag gaaaaaagac cattggattt caagagagga cactcgagtc    540

tttctgggtg acttggaaat gtcccttgtc ctctcagggt tttgatacag tatctgtaaa    600

t                                                                    601


<210>  11
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (142)..(142)
<223>  n is a, c, g, or t

<400>  11
gactggctaa ctcctgcagt ctctttaact ggacagtttc aagaggaaaa ccaagaatcc     60

ttgaagctca ccattgtatc ttcttttcca ggttgtccaa taactgcatc acctacctag    120

gggcagaagc cctcctgcag gncccttgaa aggaatgaca ccatcctgga agtctggtaa    180

ggcccctggg caggcctgtt ttagctctcc gaacctcagt ttttctatct gtaaaatggg    240

gtgacgggag agaggaatgg cagaattttg aggatccctt ctgattctga cattcagtga    300

gaatgattct gcatgtgaag gatctgattc                                     330


<210>  12
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  12
cttccttgca ggactcacca c                                               21


<210>  13
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  13
gctgatgtga aggtgcaaac tc                                              22


<210>  14
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  14
acctgcttgt cagccagctc cgg                                             23


<210>  15
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  15
gactacctca tgaagatcct cacc                                            24


<210>  16
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  16
tctccttaat gtcacgcacg att                                             23


<210>  17
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  17
cggctacagc ttcaccacca cggc                                            24


