                              Sequence Listing

<110> Genentech, Inc.
      Peale Jr., Franklin V.
      Watts, Ryan J.
      Koch, Alexander W.
      Wu, Yan
      Stawicki, Scott
      Carano, Richard
      

<120> ANTI-ROBO4 ANTIBODIES AND USES THEREFOR

<130> P2275R1 WO


<150> US 60/889,214
<151> 2007-02-09

<150> US 60/891,475
<151> 2007-02-23

<160> 187

<210> 1
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 1
 Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala
                   5                  10    

<210> 2
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 2
 Ser Ala Ser Phe Leu Tyr Ser
                   5        

<210> 3
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 3
 Gln Gln Ser Tyr Thr Thr Pro Pro Thr
                   5                

<210> 4
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 4
 Gly Phe Thr Ile Ser Gly Ser Trp Ile His
                   5                  10

<210> 5
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 5
 Ala Val Ile Thr Pro Ala Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 6
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 6
 Ala Arg Ser Asn Arg Tyr Ser Gly Gln Phe Val Pro Ala Tyr Ala
   1               5                  10                  15

 Met Asp Tyr
            

<210> 7
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 7
 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala
                   5                  10    

<210> 8
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 8
 Gly Ala Ser Ser Arg Ala Ser
                   5        

<210> 9
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 9
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 10
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 10
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 11
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 11
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Thr
                  20                  25                  30

 Tyr Cys
        

<210> 12
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 12
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                   5                  10

<210> 13
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 13
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 14
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 14
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                   5                  10            

<210> 15
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 15
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 16
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 16
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 17
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 17
 Gly Phe Thr Ile Asn Gly Tyr Tyr Ile His
                   5                  10

<210> 18
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 18
 Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 19
<211> 17
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 19
 Ala Arg Leu Ile Gly Asn Lys Phe Gly Trp Ser Ser Tyr Gly Met
   1               5                  10                  15

 Asp Tyr
        

<210> 20
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 20
 Gln Gln Ser Arg Ser Asp His Pro Thr
                   5                

<210> 21
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 21
 Gln Gln Ser Trp Ser Tyr Pro Leu Thr
                   5                

<210> 22
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 22
 Gln Gln Ser Tyr Asn Thr Pro Phe Thr
                   5                

<210> 23
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 23
 Gln Gln Tyr Tyr Ser Ser Pro Leu Thr
                   5                

<210> 24
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 24
 Gly Phe Thr Ile Thr Asn Tyr Trp Ile His
                   5                  10

<210> 25
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 25
 Gly Phe Thr Ile Asn Asn Asn Tyr Ile His
                   5                  10

<210> 26
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 26
 Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Ser
                   5                  10

<210> 27
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 27
 Gly Phe Thr Phe Ser Ser Arg Tyr Met Ser
                   5                  10

<210> 28
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 28
 Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser
                   5                  10

<210> 29
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 29
 Gly Gly Ile Tyr Pro Ala Asp Gly Tyr Thr Tyr Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 30
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 30
 Ala Ile Ile Ser Pro Thr Gly Gly Tyr Thr Asp Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 31
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 31
 Ser Thr Ile Tyr Gly Tyr Asp Gly Ser Thr Asn Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 32
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 32
 Ser Gly Ile Tyr Pro Met Gly Gly Thr Thr Tyr Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 33
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 33
 Ser Gly Ile Ser Pro Tyr Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 34
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 34
 Ala Ser Gly Gly Tyr Ser Ser Leu Ala Tyr
                   5                  10

<210> 35
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 35
 Ala Arg Asp Val Asn Val Tyr Ser Ala Arg Trp Trp Asp Tyr Val
   1               5                  10                  15

 Met Asp Tyr
            

<210> 36
<211> 16
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 36
 Ala Arg Met Ser Tyr Asn Trp Ser Ser Pro Gly His Gly Met Asp
   1               5                  10                  15

 Val
    

<210> 37
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 37
 Ala Arg Gly Asn Tyr Tyr Ser Gly Ser Glu Phe Asp Tyr
                   5                  10            

<210> 38
<211> 16
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 38
 Ala Arg Trp Gly Tyr Tyr Met Pro Tyr Gly His Pro Val Met Asp
   1               5                  10                  15

 Val
    

<210> 39
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 39
 Arg Ala Ser Gln Asp Gly Ala Arg Ser Leu Ala
                   5                  10    

<210> 40
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 40
 Arg Ala Ser Gln Asp Gly Ala Ile Tyr Leu Ala
                   5                  10    

<210> 41
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 41
 Ser Ala Ser Phe Leu Ala Ser
                   5        

<210> 42
<211> 6
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 42
 Ser Ala Ser Leu Glu Ser
                   5    

<210> 43
<211> 6
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 43
 Ser Ala Thr Leu Ala Ser
                   5    

<210> 44
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 44
 Ser Ala Ser Phe Leu Tyr Tyr
                   5        

<210> 45
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 45
 Ser Ala Ser Asn Leu Ala Ser
                   5        

<210> 46
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 46
 Ser Ala Ser Thr Leu Ala Ser
                   5        

<210> 47
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 47
 Gln Gln Ser Phe Ala Thr Pro Ala Thr
                   5                

<210> 48
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 48
 Gln Gln Ser Arg Ala Ala Leu Pro Thr
                   5                

<210> 49
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 49
 Gln Gln Ser Arg Ala Asn Thr Pro Thr
                   5                

<210> 50
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 50
 Gln Gln Ser Arg Thr Thr Pro Pro Thr
                   5                

<210> 51
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 51
 Gln Gln Pro Phe Asp Leu Pro Met Thr
                   5                

<210> 52
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 52
 Gln Gln Pro Asn Ser Thr Pro Phe Thr
                   5                

<210> 53
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 53
 Gln Gln Ser Arg Phe Asp His Pro Thr
                   5                

<210> 54
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 54
 Gln Gln Ser Tyr His Thr His Ser Thr
                   5                

<210> 55
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 55
 Gln Gln Ser Arg Asp Ile Pro Pro Thr
                   5                

<210> 56
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 56
 Gln Gln Ser Arg Asn Met Pro Ala Thr
                   5                

<210> 57
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 57
 Gln Gln Thr Arg Val Met Pro Ala Thr
                   5                

<210> 58
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 58
 Gln Gln Thr Tyr Thr Ile Pro Pro Thr
                   5                

<210> 59
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 59
 Gln Gln Ser Tyr Ala Tyr Pro Phe Thr
                   5                

<210> 60
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 60
 Gln Gln Ser Tyr Asp Leu Pro Phe Thr
                   5                

<210> 61
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 61
 Gln Gln Ser Tyr Gly Gly Pro Phe Thr
                   5                

<210> 62
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 62
 Gln Gln Ser Tyr Asn Tyr Pro Phe Thr
                   5                

<210> 63
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 63
 Gln Gln Phe Tyr Ser Asp Pro Phe Thr
                   5                

<210> 64
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 64
 Gln Gln Gly Tyr Asn Tyr Pro Phe Thr
                   5                

<210> 65
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 65
 Gly Phe Ser Ile Tyr Ser Tyr Tyr Phe Glu
                   5                  10

<210> 66
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 66
 Gly Phe Thr Leu Asp Gly Tyr Tyr Leu Gln
                   5                  10

<210> 67
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 67
 Gly Phe Ser Ile Asn Gly Tyr Tyr Asn Gln
                   5                  10

<210> 68
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 68
 Gly Arg Ile Tyr Ser Ala Gly Gly His Thr Ala Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 69
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 69
 Gly Phe Ile Tyr Pro Ala Gly Gly Lys Thr Glu Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 70
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 70
 Gly Phe Ile Tyr Pro Ala Gly Gly Ala Thr Ile Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 71
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<400> 71
 Gly Phe Ile Tyr Pro Ala Leu Ser Val Ile Glu Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 72
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 72
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 73
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 73
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 74
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 74
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 75
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 75
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 76
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 76
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser
                  20                  25                  30

 Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Trp Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 77
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 77
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser
                  20                  25                  30

 Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr Asn Thr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 78
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 78
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser
                  20                  25                  30

 Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Tyr Tyr Ser Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 79
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 79
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Phe Ala Thr Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 80
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 80
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Arg Ala Ala Leu Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 81
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 81
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Arg Ser Asp His Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 82
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 82
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Arg Ala Asn Thr Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 83
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 83
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Arg Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 84
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 84
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Pro Phe Asp Leu Pro Met Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 85
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 85
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Pro Asn Ser Thr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 86
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 86
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Arg Phe Asp His Pro Thr Phe Gly Gln Gly Thr Lys Met Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 87
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 87
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Tyr Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr His Thr His Ser Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 88
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 88
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Arg Asp Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 89
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 89
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Arg Asn Met Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 90
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 90
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Thr Arg Val Met Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 91
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 91
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Tyr Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Thr Tyr Thr Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 92
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 92
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Ala Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr Ala Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 93
<211> 107
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 93
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Leu Glu Ser Gly Val Pro Ser Arg
                  50                  55                  60

 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                  65                  70                  75

 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser
                  80                  85                  90

 Tyr Asp Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
                  95                 100                 105

 Lys Arg
        

<210> 94
<211> 107
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 94
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Thr Leu Ala Ser Gly Val Pro Ser Arg
                  50                  55                  60

 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                  65                  70                  75

 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser
                  80                  85                  90

 Tyr Gly Gly Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
                  95                 100                 105

 Lys Arg
        

<210> 95
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 95
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Ala Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr Asn Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 96
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 96
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Gly Ala
                  20                  25                  30

 Arg Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Asn Leu Ala Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Phe Tyr Ser Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 97
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 97
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Gly Ala
                  20                  25                  30

 Ile Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Gly Tyr Asn Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 98
<211> 107
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 98
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys
        

<210> 99
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 99
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 100
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 100
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                   5                  10

<210> 101
<211> 14
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 101
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                   5                  10                

<210> 102
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 102
 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro
   1               5                  10                  15

 Gly Glu Pro Ala Ser Ile Ser Cys
                  20            

<210> 103
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 103
 Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr
   1               5                  10                  15

<210> 104
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 104
 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 105
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 105
 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro
   1               5                  10                  15

 Gly Glu Arg Ala Thr Leu Ser Cys
                  20            

<210> 106
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 106
 Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
   1               5                  10                  15

<210> 107
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 107
 Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 108
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 108
 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Glu Arg Ala Thr Ile Asn Cys
                  20            

<210> 109
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 109
 Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 110
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 110
 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 111
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 111
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

<210> 112
<211> 14
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 112
 Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
                   5                  10                

<210> 113
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 113
 Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met
   1               5                  10                  15

 Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ala Arg
        

<210> 114
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 114
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser
                  20                  25

<210> 115
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 115
 Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
                   5                  10            

<210> 116
<211> 31
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 116
 Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met
   1               5                  10                  15

 Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ala
    

<210> 117
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 117
 Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met
   1               5                  10                  15

 Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 118
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 118
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser
                  20                  25                  30

<210> 119
<211> 14
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 119
 Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly
                   5                  10                

<210> 120
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 120
 Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
   1               5                  10                  15

 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ala Arg
        

<210> 121
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 121
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
                  20                  25

<210> 122
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 122
 Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
                   5                  10            

<210> 123
<211> 31
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 123
 Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
   1               5                  10                  15

 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ala
    

<210> 124
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 124
 Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
   1               5                  10                  15

 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 125
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 125
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

<210> 126
<211> 14
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 126
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
                   5                  10                

<210> 127
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 127
 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ala Arg
        

<210> 128
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 128
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 129
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 129
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                   5                  10            

<210> 130
<211> 31
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 130
 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ala
    

<210> 131
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 131
 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 132
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 132
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys
                  20                  25                  30

<210> 133
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 133
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ser Arg
        

<210> 134
<211> 31
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 134
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ser
    

<210> 135
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 135
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ala Arg
        

<210> 136
<211> 31
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 136
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ala
    

<210> 137
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain framework region

<400> 137
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 138
<211> 1007
<212> PRT
<213> Homo sapiens

<400> 138
 Met Gly Ser Gly Gly Asp Ser Leu Leu Gly Gly Arg Gly Ser Leu
   1               5                  10                  15

 Pro Leu Leu Leu Leu Leu Ile Met Gly Gly Met Ala Gln Asp Ser
                  20                  25                  30

 Pro Pro Gln Ile Leu Val His Pro Gln Asp Gln Leu Phe Gln Gly
                  35                  40                  45

 Pro Gly Pro Ala Arg Met Ser Cys Arg Ala Ser Gly Gln Pro Pro
                  50                  55                  60

 Pro Thr Ile Arg Trp Leu Leu Asn Gly Gln Pro Leu Ser Met Val
                  65                  70                  75

 Pro Pro Asp Pro His His Leu Leu Pro Asp Gly Thr Leu Leu Leu
                  80                  85                  90

 Leu Gln Pro Pro Ala Arg Gly His Ala His Asp Gly Gln Ala Leu
                  95                 100                 105

 Ser Thr Asp Leu Gly Val Tyr Thr Cys Glu Ala Ser Asn Arg Leu
                 110                 115                 120

 Gly Thr Ala Val Ser Arg Gly Ala Arg Leu Ser Val Ala Val Leu
                 125                 130                 135

 Arg Glu Asp Phe Gln Ile Gln Pro Arg Asp Met Val Ala Val Val
                 140                 145                 150

 Gly Glu Gln Phe Thr Leu Glu Cys Gly Pro Pro Trp Gly His Pro
                 155                 160                 165

 Glu Pro Thr Val Ser Trp Trp Lys Asp Gly Lys Pro Leu Ala Leu
                 170                 175                 180

 Gln Pro Gly Arg His Thr Val Ser Gly Gly Ser Leu Leu Met Ala
                 185                 190                 195

 Arg Ala Glu Lys Ser Asp Glu Gly Thr Tyr Met Cys Val Ala Thr
                 200                 205                 210

 Asn Ser Ala Gly His Arg Glu Ser Arg Ala Ala Arg Val Ser Ile
                 215                 220                 225

 Gln Glu Pro Gln Asp Tyr Thr Glu Pro Val Glu Leu Leu Ala Val
                 230                 235                 240

 Arg Ile Gln Leu Glu Asn Val Thr Leu Leu Asn Pro Asp Pro Ala
                 245                 250                 255

 Glu Gly Pro Lys Pro Arg Pro Ala Val Trp Leu Ser Trp Lys Val
                 260                 265                 270

 Ser Gly Pro Ala Ala Pro Ala Gln Ser Tyr Thr Ala Leu Phe Arg
                 275                 280                 285

 Thr Gln Thr Ala Pro Gly Gly Gln Gly Ala Pro Trp Ala Glu Glu
                 290                 295                 300

 Leu Leu Ala Gly Trp Gln Ser Ala Glu Leu Gly Gly Leu His Trp
                 305                 310                 315

 Gly Gln Asp Tyr Glu Phe Lys Val Arg Pro Ser Ser Gly Arg Ala
                 320                 325                 330

 Arg Gly Pro Asp Ser Asn Val Leu Leu Leu Arg Leu Pro Glu Lys
                 335                 340                 345

 Val Pro Ser Ala Pro Pro Gln Glu Val Thr Leu Lys Pro Gly Asn
                 350                 355                 360

 Gly Thr Val Phe Val Ser Trp Val Pro Pro Pro Ala Glu Asn His
                 365                 370                 375

 Asn Gly Ile Ile Arg Gly Tyr Gln Val Trp Ser Leu Gly Asn Thr
                 380                 385                 390

 Ser Leu Pro Pro Ala Asn Trp Thr Val Val Gly Glu Gln Thr Gln
                 395                 400                 405

 Leu Glu Ile Ala Thr His Met Pro Gly Ser Tyr Cys Val Gln Val
                 410                 415                 420

 Ala Ala Val Thr Gly Ala Gly Ala Gly Glu Pro Ser Arg Pro Val
                 425                 430                 435

 Cys Leu Leu Leu Glu Gln Ala Met Glu Arg Ala Thr Gln Glu Pro
                 440                 445                 450

 Ser Glu His Gly Pro Trp Thr Leu Glu Gln Leu Arg Ala Thr Leu
                 455                 460                 465

 Lys Arg Pro Glu Val Ile Ala Thr Cys Gly Val Ala Leu Trp Leu
                 470                 475                 480

 Leu Leu Leu Gly Thr Ala Val Cys Ile His Arg Arg Arg Arg Ala
                 485                 490                 495

 Arg Val His Leu Gly Pro Gly Leu Tyr Arg Tyr Thr Ser Glu Asp
                 500                 505                 510

 Ala Ile Leu Lys His Arg Met Asp His Ser Asp Ser Gln Trp Leu
                 515                 520                 525

 Ala Asp Thr Trp Arg Ser Thr Ser Gly Ser Arg Asp Leu Ser Ser
                 530                 535                 540

 Ser Ser Ser Leu Ser Ser Arg Leu Gly Ala Asp Ala Arg Asp Pro
                 545                 550                 555

 Leu Asp Cys Arg Arg Ser Leu Leu Ser Trp Asp Ser Arg Ser Pro
                 560                 565                 570

 Gly Val Pro Leu Leu Pro Asp Thr Ser Thr Phe Tyr Gly Ser Leu
                 575                 580                 585

 Ile Ala Glu Leu Pro Ser Ser Thr Pro Ala Arg Pro Ser Pro Gln
                 590                 595                 600

 Val Pro Ala Val Arg Arg Leu Pro Pro Gln Leu Ala Gln Leu Ser
                 605                 610                 615

 Ser Pro Cys Ser Ser Ser Asp Ser Leu Cys Ser Arg Arg Gly Leu
                 620                 625                 630

 Ser Ser Pro Arg Leu Ser Leu Ala Pro Ala Glu Ala Trp Lys Ala
                 635                 640                 645

 Lys Lys Lys Gln Glu Leu Gln His Ala Asn Ser Ser Pro Leu Leu
                 650                 655                 660

 Arg Gly Ser His Ser Leu Glu Leu Arg Ala Cys Glu Leu Gly Asn
                 665                 670                 675

 Arg Gly Ser Lys Asn Leu Ser Gln Ser Pro Gly Ala Val Pro Gln
                 680                 685                 690

 Ala Leu Val Ala Trp Arg Ala Leu Gly Pro Lys Leu Leu Ser Ser
                 695                 700                 705

 Ser Asn Glu Leu Val Thr Arg His Leu Pro Pro Ala Pro Leu Phe
                 710                 715                 720

 Pro His Glu Thr Pro Pro Thr Gln Ser Gln Gln Thr Gln Pro Pro
                 725                 730                 735

 Val Ala Pro Gln Ala Pro Ser Ser Ile Leu Leu Pro Ala Ala Pro
                 740                 745                 750

 Ile Pro Ile Leu Ser Pro Cys Ser Pro Pro Ser Pro Gln Ala Ser
                 755                 760                 765

 Ser Leu Ser Gly Pro Ser Pro Ala Ser Ser Arg Leu Ser Ser Ser
                 770                 775                 780

 Ser Leu Ser Ser Leu Gly Glu Asp Gln Asp Ser Val Leu Thr Pro
                 785                 790                 795

 Glu Glu Val Ala Leu Cys Leu Glu Leu Ser Glu Gly Glu Glu Thr
                 800                 805                 810

 Pro Arg Asn Ser Val Ser Pro Met Pro Arg Ala Pro Ser Pro Pro
                 815                 820                 825

 Thr Thr Tyr Gly Tyr Ile Ser Val Pro Thr Ala Ser Glu Phe Thr
                 830                 835                 840

 Asp Met Gly Arg Thr Gly Gly Gly Val Gly Pro Lys Gly Gly Val
                 845                 850                 855

 Leu Leu Cys Pro Pro Arg Pro Cys Leu Thr Pro Thr Pro Ser Glu
                 860                 865                 870

 Gly Ser Leu Ala Asn Gly Trp Gly Ser Ala Ser Glu Asp Asn Ala
                 875                 880                 885

 Ala Ser Ala Arg Ala Ser Leu Val Ser Ser Ser Asp Gly Ser Phe
                 890                 895                 900

 Leu Ala Asp Ala His Phe Ala Arg Ala Leu Ala Val Ala Val Asp
                 905                 910                 915

 Ser Phe Gly Phe Gly Leu Glu Pro Arg Glu Ala Asp Cys Val Phe
                 920                 925                 930

 Ile Asp Ala Ser Ser Pro Pro Ser Pro Arg Asp Glu Ile Phe Leu
                 935                 940                 945

 Thr Pro Asn Leu Ser Leu Pro Leu Trp Glu Trp Arg Pro Asp Trp
                 950                 955                 960

 Leu Glu Asp Met Glu Val Ser His Thr Gln Arg Leu Gly Arg Gly
                 965                 970                 975

 Met Pro Pro Trp Pro Pro Asp Ser Gln Ile Ser Ser Gln Arg Ser
                 980                 985                 990

 Gln Leu His Cys Arg Met Pro Lys Ala Gly Ala Ser Pro Val Asp
                 995                1000                1005

 Tyr Ser
        

<210> 139
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 139
 Phe Gly Gln Gly Thr Lys Met Glu Ile Lys Arg
                   5                  10    

<210> 140
<211> 125
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 140
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser
                  20                  25                  30

 Gly Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Val Ile Thr Pro Ala Gly Gly Tyr Thr Tyr Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asn Arg Tyr Ser Gly Gln
                  95                 100                 105

 Phe Val Pro Ala Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu
                 110                 115                 120

 Val Thr Val Ser Ser
                 125

<210> 141
<211> 117
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 141
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr
                  20                  25                  30

 Asn Tyr Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Gly Ile Tyr Pro Ala Asp Gly Tyr Thr Tyr Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Ser Gly Gly Tyr Ser Ser Leu Ala
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115        

<210> 142
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 142
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 143
<211> 125
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 143
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Asn Asn Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Ile Ile Ser Pro Thr Gly Gly Tyr Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Asp Val Asn Val Tyr Ser Ala
                  95                 100                 105

 Arg Trp Trp Asp Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Leu
                 110                 115                 120

 Val Thr Val Ser Ser
                 125

<210> 144
<211> 123
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 144
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ser Thr Ile Tyr Gly Tyr Asp Gly Ser Thr Asn Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Met Ser Tyr Asn Trp Ser Ser
                  95                 100                 105

 Pro Gly His Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr
                 110                 115                 120

 Val Ser Ser
            

<210> 145
<211> 120
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 145
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Ser Arg Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ser Gly Ile Tyr Pro Met Gly Gly Thr Thr Tyr Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asn Tyr Tyr Ser Gly Ser
                  95                 100                 105

 Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                 120

<210> 146
<211> 123
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 146
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ser Gly Ile Ser Pro Tyr Gly Gly Tyr Thr Tyr Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Tyr Tyr Met Pro Tyr
                  95                 100                 105

 Gly His Pro Val Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr
                 110                 115                 120

 Val Ser Ser
            

<210> 147
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 147
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ile Tyr
                  20                  25                  30

 Ser Tyr Tyr Phe Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Arg Ile Tyr Ser Ala Gly Gly His Thr Ala Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 148
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 148
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 149
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 149
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 150
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 150
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 151
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 151
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 152
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 152
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp
                  20                  25                  30

 Gly Tyr Tyr Leu Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Lys Thr Glu Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 153
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 153
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Asn Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Ala Thr Ile Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 154
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 154
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 155
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 155
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Leu Ser Val Ile Glu Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 156
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 156
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 157
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 157
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 158
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 158
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 159
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 159
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 160
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 160
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 161
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 161
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 162
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 162
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 163
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 163
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 164
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 164
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 165
<211> 124
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain variable region

<400> 165
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser
                

<210> 166
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 166
 Phe Gly Gln Gly Thr Lys Met Glu Ile Lys
                   5                  10

<210> 167
<211> 107
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 167
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys
        

<210> 168
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 168
 Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 169
<211> 454
<212> PRT
<213> Artificial sequence

<220>
<223> antibody heavy chain

<400> 169
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn
                  20                  25                  30

 Gly Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Phe Ile Tyr Pro Ala Gly Gly Asp Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ile Gly Asn Lys Phe Gly
                  95                 100                 105

 Trp Ser Ser Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
                 110                 115                 120

 Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu
                 125                 130                 135

 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
                 140                 145                 150

 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
                 155                 160                 165

 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                 170                 175                 180

 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
                 185                 190                 195

 Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
                 200                 205                 210

 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
                 215                 220                 225

 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
                 230                 235                 240

 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                 245                 250                 255

 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                 260                 265                 270

 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
                 275                 280                 285

 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                 290                 295                 300

 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                 305                 310                 315

 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
                 320                 325                 330

 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
                 335                 340                 345

 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
                 350                 355                 360

 Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
                 365                 370                 375

 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
                 380                 385                 390

 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
                 395                 400                 405

 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                 410                 415                 420

 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                 425                 430                 435

 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                 440                 445                 450

 Ser Pro Gly Lys
                

<210> 170
<211> 214
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain

<400> 170
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Thr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
                 110                 115                 120

 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
                 125                 130                 135

 Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val
                 140                 145                 150

 Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu
                 155                 160                 165

 Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr
                 170                 175                 180

 Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu
                 185                 190                 195

 Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn
                 200                 205                 210

 Arg Gly Glu Cys
                

<210> 171
<211> 214
<212> PRT
<213> Artificial sequence

<220>
<223> His-tagged Robo4

<400> 171
 Gln Asp Ser Pro Pro Gln Ile Leu Val His Pro Gln Asp Gln Leu
   1               5                  10                  15

 Phe Gln Gly Pro Gly Pro Ala Arg Met Ser Cys Gln Ala Ser Gly
                  20                  25                  30

 Gln Pro Pro Pro Thr Ile Arg Trp Leu Leu Asn Gly Gln Pro Leu
                  35                  40                  45

 Ser Met Val Pro Pro Asp Pro His His Leu Leu Pro Asp Gly Thr
                  50                  55                  60

 Leu Leu Leu Leu Gln Pro Pro Ala Arg Gly His Ala His Asp Gly
                  65                  70                  75

 Gln Ala Leu Ser Thr Asp Leu Gly Val Tyr Thr Cys Glu Ala Ser
                  80                  85                  90

 Asn Arg Leu Gly Thr Ala Val Ser Arg Gly Ala Arg Leu Ser Val
                  95                 100                 105

 Ala Val Leu Arg Glu Asp Phe Gln Ile Gln Pro Arg Asp Met Val
                 110                 115                 120

 Ala Val Val Gly Glu Gln Phe Thr Leu Glu Cys Gly Pro Pro Trp
                 125                 130                 135

 Gly His Pro Glu Pro Thr Val Ser Trp Trp Lys Asp Gly Lys Pro
                 140                 145                 150

 Leu Ala Leu Gln Pro Gly Arg His Thr Val Ser Gly Gly Ser Leu
                 155                 160                 165

 Leu Met Ala Arg Ala Glu Lys Ser Asp Glu Gly Thr Tyr Met Cys
                 170                 175                 180

 Val Ala Thr Asn Ser Ala Gly His Arg Glu Ser Arg Ala Ala Arg
                 185                 190                 195

 Val Ser Ile Gln Glu Pro Gln Asp Tyr Arg Ala His His His His
                 200                 205                 210

 His His His His
                

<210> 172
<211> 243
<212> PRT
<213> Artificial sequence

<220>
<223> His-tagged Robo4

<400> 172
 Met Gly Ser Gly Gly Thr Gly Leu Leu Gly Thr Glu Trp Pro Leu
   1               5                  10                  15

 Pro Leu Leu Leu Leu Phe Ile Met Gly Gly Glu Ala Leu Asp Ser
                  20                  25                  30

 Pro Pro Gln Ile Leu Val His Pro Gln Asp Gln Leu Leu Gln Gly
                  35                  40                  45

 Ser Gly Pro Ala Lys Met Arg Cys Arg Ser Ser Gly Gln Pro Pro
                  50                  55                  60

 Pro Thr Ile Arg Trp Leu Leu Asn Gly Gln Pro Leu Ser Met Ala
                  65                  70                  75

 Thr Pro Asp Leu His Tyr Leu Leu Pro Asp Gly Thr Leu Leu Leu
                  80                  85                  90

 His Arg Pro Ser Val Gln Gly Arg Pro Gln Asp Asp Gln Asn Ile
                  95                 100                 105

 Leu Ser Ala Ile Leu Gly Val Tyr Thr Cys Glu Ala Ser Asn Arg
                 110                 115                 120

 Leu Gly Thr Ala Val Ser Arg Gly Ala Arg Leu Ser Val Ala Val
                 125                 130                 135

 Leu Gln Glu Asp Phe Gln Ile Gln Pro Arg Asp Thr Val Ala Val
                 140                 145                 150

 Val Gly Glu Ser Leu Val Leu Glu Cys Gly Pro Pro Trp Gly Tyr
                 155                 160                 165

 Pro Lys Pro Ser Val Ser Trp Trp Lys Asp Gly Lys Pro Leu Val
                 170                 175                 180

 Leu Gln Pro Gly Arg Arg Thr Val Ser Gly Asp Ser Leu Met Val
                 185                 190                 195

 Ser Arg Ala Glu Lys Asn Asp Ser Gly Thr Tyr Met Cys Met Ala
                 200                 205                 210

 Thr Asn Asn Ala Gly Gln Arg Glu Ser Arg Ala Ala Arg Val Ser
                 215                 220                 225

 Ile Gln Glu Ser Gln Asp His Arg Arg Ala His His His His His
                 230                 235                 240

 His His His
            

<210> 173
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> antibody light chain framework region

<400> 173
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 174
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 5
<223> X1 is D or S

<220>
<221> Xaa
<222> 6
<223> X2 is V, I or G

<220>
<221> Xaa
<222> 7
<223> X3 is S or A

<220>
<221> Xaa
<222> 8
<223> X4 is T, S, R, or I

<220>
<221> Xaa
<222> 9
<223> X5 is A, Y or S

<220>
<221> Xaa
<222> 10
<223> X6 is V or L

<400> 174
 Arg Ala Ser Gln Xaa Xaa Xaa Xaa Xaa Xaa Ala
                   5                  10    

<210> 175
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 1
<223> X1 is S or G

<220>
<221> Xaa
<222> 3
<223> X2 is T or S

<220>
<221> Xaa
<222> 4
<223> X3 is F, S, L, N, or T

<220>
<221> Xaa
<222> 5
<223> X4 is L, R, E, or A

<220>
<221> Xaa
<222> 6
<223> X5 is Y, A, or S

<220>
<221> Xaa
<222> 7
<223> X6 is S or Y

<400> 175
 Xaa Ala Xaa Xaa Xaa Xaa Xaa
                   5        

<210> 176
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 3
<223> X1 is S, Y, P, T, F or G

<220>
<221> Xaa
<222> 4
<223> X2 is Y, W, F, R or N

<220>
<221> Xaa
<222> 5
<223> X3 is T, S, N, A, D, F,  H, V or G

<220>
<221> Xaa
<222> 6
<223> X4 is T, Y, S, A, D, N, L, I, M, Y or G

<220>
<221> Xaa
<222> 7
<223> X5 is P, L, H, or T

<220>
<221> Xaa
<222> 8
<223> X6 is P, L, F, A, M or S

<400> 176
 Gln Gln Xaa Xaa Xaa Xaa Xaa Xaa Thr
                   5                

<210> 177
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 2
<223> X1 is F or Y

<220>
<221> Xaa
<222> 3
<223> X2 is T or S

<220>
<221> Xaa
<222> 4
<223> X3 is I, F, or L

<220>
<221> Xaa
<222> 5
<223> X4 is S, N, T, Y, D, or K

<220>
<221> Xaa
<222> 6
<223> X5 is G, N, or S

<220>
<221> Xaa
<222> 7
<223> X6 is S, Y, N or R

<220>
<221> Xaa
<222> 8
<223> X7 is W, Y or A

<220>
<221> Xaa
<222> 9
<223> X8 is I, M, F, L or N

<220>
<221> Xaa
<222> 10
<223> X9 is H, S, E or Q

<400> 177
 Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                   5                  10

<210> 178
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 1
<223> X1 is A, G or S

<220>
<221> Xaa
<222> 2
<223> X2 is V, F, G, I, T or R

<220>
<221> Xaa
<222> 4
<223> X3 is T, Y or S

<220>
<221> Xaa
<222> 5
<223> X4 is P, G or S

<220>
<221> Xaa
<222> 6
<223> X5 is A, T, Y, or M

<220>
<221> Xaa
<222> 7
<223> X6 is G, D, or L

<220>
<221> Xaa
<222> 8
<223> X7 is G or S

<220>
<221> Xaa
<222> 9
<223> X8 is Y, D, S, T, H, K, A or V

<220>
<221> Xaa
<222> 10
<223> X9 is T or I

<220>
<221> Xaa
<222> 11
<223> X10 is Y, D, N, A, E, or I

<400> 178
 Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 179
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 2
<223> X1 is R or S

<220>
<221> Xaa
<222> 3
<223> X2 is S, L, G, D, M or W

<220>
<221> Xaa
<222> 4
<223> X3 is N, I, G, V, or S

<220>
<221> Xaa
<222> 5
<223> X4 is R, G, Y or N

<220>
<221> Xaa
<222> 6
<223> X5 is Y, N, S, or V

<220>
<221> Xaa
<222> 7
<223> X6 is S, K, Y, W, or M

<220>
<221> Xaa
<222> 8
<223> X7 is G, F, S, P or a deletion

<220>
<221> Xaa
<222> 9
<223> X8 is Q, G, A, S, Y or a deletion

<220>
<221> Xaa
<222> 10
<223> X9 is F, W, R, P, E, G or a deletion

<220>
<221> Xaa
<222> 11
<223> X10 is V, S, W, G, H, or a deletion

<220>
<221> Xaa
<222> 12
<223> X11 is P, S, W, H, or a deletion

<220>
<221> Xaa
<222> 13
<223> X12 is A, Y, D, G, V, or a deletion

<220>
<221> Xaa
<222> 14
<223> X13 is Y, G or a deletion

<220>
<221> Xaa
<222> 15
<223> X14 is A, V or a deletion

<220>
<221> Xaa
<222> 16
<223> X15 is M, L, or F

<220>
<221> Xaa
<222> 17
<223> X16 is D or A

<220>
<221> Xaa
<222> 18
<223> X17 is Y or V

<400> 179
 Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
   1               5                  10                  15

 Xaa Xaa Xaa
            

<210> 180
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 2
<223> X1 is F or Y

<220>
<221> Xaa
<222> 3
<223> X2 is T or S

<220>
<221> Xaa
<222> 4
<223> X3 is I, F, or L

<220>
<221> Xaa
<222> 5
<223> X4 is S, T, Y, D, or K

<220>
<221> Xaa
<222> 6
<223> X5 is G, N, or S

<220>
<221> Xaa
<222> 7
<223> X6 is S, N or R

<220>
<221> Xaa
<222> 8
<223> X7 is W or A

<220>
<221> Xaa
<222> 9
<223> X8 is I, M, F, L or N

<220>
<221> Xaa
<222> 10
<223> X9 is H, S, E or Q

<400> 180
 Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                   5                  10

<210> 181
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 1
<223> X1 is A or S

<220>
<221> Xaa
<222> 2
<223> X2 is V, G, I, T, or R

<220>
<221> Xaa
<222> 4
<223> X3 is T or S

<220>
<221> Xaa
<222> 5
<223> X4 is P, G, or S

<220>
<221> Xaa
<222> 6
<223> X5 is A, T, Y, or M

<220>
<221> Xaa
<222> 7
<223> X6 is G, D, or L

<220>
<221> Xaa
<222> 8
<223> X7 is G or S

<220>
<221> Xaa
<222> 9
<223> X8 is Y, S, T, H, K, A or V

<220>
<221> Xaa
<222> 10
<223> X9 is T or I

<220>
<221> Xaa
<222> 11
<223> X10 is Y, N, A, E, or I

<400> 181
 Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 182
<211> 16
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 1
<223> X1 is S, G, D, M or W

<220>
<221> Xaa
<222> 2
<223> X2 is N, G, V, or S

<220>
<221> Xaa
<222> 3
<223> X3 is R, Y, or N

<220>
<221> Xaa
<222> 4
<223> X4 is Y, S, or V

<220>
<221> Xaa
<222> 5
<223> X5 is S, Y, W, or M

<220>
<221> Xaa
<222> 6
<223> X6 is G, S, P, or a deletion

<220>
<221> Xaa
<222> 7
<223> X7 is Q, A, S, Y, or a deletion

<220>
<221> Xaa
<222> 8
<223> X8 is F, R, P, E, G, or a deletion

<220>
<221> Xaa
<222> 9
<223> X9 is V, W, G, H, or a deletion

<220>
<221> Xaa
<222> 10
<223> X10 is P, W, G, H, or a deletion

<220>
<221> Xaa
<222> 11
<223> X11 is A, D, G, V, or a deletion

<220>
<221> Xaa
<222> 12
<223> X12 is Y or a deletion

<220>
<221> Xaa
<222> 13
<223> X13 is A or V

<220>
<221> Xaa
<222> 14
<223> X14 is M, L, or F

<220>
<221> Xaa
<222> 16
<223> X15 is Y or V

<400> 182
 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp
   1               5                  10                  15

 Xaa
    

<210> 183
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 6
<223> X1 is V or G

<220>
<221> Xaa
<222> 7
<223> X2 is S or A

<220>
<221> Xaa
<222> 8
<223> X3 is T, R, or I

<220>
<221> Xaa
<222> 9
<223> X4 is A, S, or Y

<220>
<221> Xaa
<222> 10
<223> X5 is V or L

<400> 183
 Arg Ala Ser Gln Asp Xaa Xaa Xaa Xaa Xaa Ala
                   5                  10    

<210> 184
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 3
<223> X1 is S or T

<220>
<221> Xaa
<222> 4
<223> X2 is F, L, N or T

<220>
<221> Xaa
<222> 5
<223> X3 is L, E, or A

<220>
<221> Xaa
<222> 6
<223> X4 is Y, A, or S

<220>
<221> Xaa
<222> 7
<223> X5 is S, Y or a deletion

<400> 184
 Ser Ala Xaa Xaa Xaa Xaa Xaa
                   5        

<210> 185
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 3
<223> X1 is S, P, T, F, or G

<220>
<221> Xaa
<222> 4
<223> X2 is Y, F, R, or N

<220>
<221> Xaa
<222> 5
<223> X3 is T, A, S, D, F, H, N, V, or G

<220>
<221> Xaa
<222> 6
<223> X4 is T, A, D, N, L, I, M, Y, or G

<220>
<221> Xaa
<222> 7
<223> X5 is P, L, H, or T

<220>
<221> Xaa
<222> 8
<223> X6 is P, A, M, F, or S

<400> 185
 Gln Gln Xaa Xaa Xaa Xaa Xaa Xaa Thr
                   5                

<210> 186
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 3
<223> X1 is T or S

<220>
<221> Xaa
<222> 4
<223> X2 is I or L

<220>
<221> Xaa
<222> 5
<223> X3 is N, Y, D, or K

<220>
<221> Xaa
<222> 9
<223> X4 is I, F, L or N

<220>
<221> Xaa
<222> 10
<223> X5 is H, E, or Q

<400> 186
 Gly Phe Xaa Xaa Xaa Gly Tyr Tyr Xaa Xaa
                   5                  10

<210> 187
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> antibody hypervariable region

<220>
<221> Xaa
<222> 2
<223> X1 is F or R

<220>
<221> Xaa
<222> 5
<223> X2 is P or S

<220>
<221> Xaa
<222> 7
<223> X3 is G or L

<220>
<221> Xaa
<222> 9
<223> X4 is D, H, K, A, or V

<220>
<221> Xaa
<222> 11
<223> X5 is D, A, E or I

<400> 187
 Gly Xaa Ile Tyr Xaa Ala Xaa Gly Xaa Thr Xaa Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

