                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF CHICAGO
 
<120>  COMBINATION THERAPY FOR TREATING CANCER

<130>  092234-9114-WO00

<140>  New International Application
<141>  2008-02-08

<150>  US 60/888,823
<151>  2007-02-08

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  1

Met Glu Ser Val Val Gln Pro Ser Val Phe Val Val Asp Gly Gln Thr 
1               5                   10                  15      


Asp Ile Pro Phe Arg Arg Leu Glu Gln Asn His Arg Arg Arg Arg Cys 
            20                  25                  30          


Gly Thr Val Gln Val Ser Leu Ala Leu Val Leu Leu Leu Gly Ala Gly 
        35                  40                  45              


Leu Ala Thr Gln Gly Trp Phe Leu Leu Arg Leu His Gln Arg Leu Gly 
    50                  55                  60                  


Asp Ile Val Ala His Leu Pro Asp Gly Gly Lys Gly Ser Trp Glu Lys 
65                  70                  75                  80  


Leu Ile Gln Asp Gln Arg Ser His Gln Ala Asn Pro Ala Ala His Leu 
                85                  90                  95      


Thr Gly Ala Asn Ala Ser Leu Ile Gly Ile Gly Gly Pro Leu Leu Trp 
            100                 105                 110         


Glu Thr Arg Leu Gly Leu Ala Phe Leu Arg Gly Leu Thr Tyr His Asp 
        115                 120                 125             


Gly Ala Leu Val Thr Met Glu Pro Gly Tyr Tyr Tyr Val Tyr Ser Lys 
    130                 135                 140                 


Val Gln Leu Ser Gly Val Gly Cys Pro Gln Gly Leu Ala Asn Gly Leu 
145                 150                 155                 160 


Pro Ile Thr His Gly Leu Tyr Lys Arg Thr Ser Arg Tyr Pro Lys Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Arg Arg Ser Pro Cys Gly Arg Ala Asn Ser 
            180                 185                 190         


Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu 
        195                 200                 205             


Glu Ala Gly Glu Glu Val Val Val Arg Val Pro Gly Asn Arg Leu Val 
    210                 215                 220                 


Arg Pro Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 


<210>  2
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  3
<211>  235
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  mouse mutant-LIGHT

<400>  3

Met Glu Ser Val Val Gln Pro Ser Val Phe Val Val Asp Gly Gln Thr 
1               5                   10                  15      


Asp Ile Pro Phe Arg Arg Leu Glu Gln Asn His Arg Arg Arg Arg Cys 
            20                  25                  30          


Gly Thr Val Gln Val Ser Leu Ala Leu Val Leu Leu Leu Gly Ala Gly 
        35                  40                  45              


Leu Ala Thr Gln Gly Trp Phe Leu Leu Arg Leu His Gln Arg Leu Gly 
    50                  55                  60                  


Asp Ile Val Ala His Leu Pro Asp Gly Gly Lys Gly Ser Trp Gln Asp 
65                  70                  75                  80  


Gln Arg Ser His Gln Ala Asn Pro Ala Ala His Leu Thr Gly Ala Asn 
                85                  90                  95      


Ala Ser Leu Ile Gly Ile Gly Gly Pro Leu Leu Trp Glu Thr Arg Leu 
            100                 105                 110         


Gly Leu Ala Phe Leu Arg Gly Leu Thr Tyr His Asp Gly Ala Leu Val 
        115                 120                 125             


Thr Met Glu Pro Gly Tyr Tyr Tyr Val Tyr Ser Lys Val Gln Leu Ser 
    130                 135                 140                 


Gly Val Gly Cys Pro Gln Gly Leu Ala Asn Gly Leu Pro Ile Thr His 
145                 150                 155                 160 


Gly Leu Tyr Lys Arg Thr Ser Arg Tyr Pro Lys Glu Leu Glu Leu Leu 
                165                 170                 175     


Val Ser Arg Arg Ser Pro Cys Gly Arg Ala Asn Ser Ser Arg Val Trp 
            180                 185                 190         


Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu 
        195                 200                 205             


Glu Val Val Val Arg Val Pro Gly Asn Arg Leu Val Arg Pro Arg Asp 
    210                 215                 220                 


Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235 


<210>  4
<211>  236
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  human mutant-LIGHT

<400>  4

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly 
                85                  90                  95      


Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
            100                 105                 110         


Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
        115                 120                 125             


Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
    130                 135                 140                 


Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
145                 150                 155                 160 


Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
                165                 170                 175     


Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
            180                 185                 190         


Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
        195                 200                 205             


Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
    210                 215                 220                 


Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235     


