                         SEQUENCE LISTING

<110>  Komalavilas, Padmini
       Flynn, Charles R
       Thresher, Jeffery
       Lopes, Luciana B
       Furnish, Elizabeth
       Brophy, Colleen
 
<120>  Methods for treating airway smooth muscle disorders in subjects 
       desensitized to B-adrenergic receptor agonist therapy

<130>  07-038-PCT

<150>  60/897,104
<151>  2007-01-24

<160>  47    

<170>  PatentIn version 3.4

<210>  1
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1

Trp Leu Arg Arg 
1               


<210>  2
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is absent or comprises a transduction domain

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is absent or W

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is absent or L

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  X is absent or R

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is selected from the group consisting of S, T, Y, D, E, 
       hydroxylysine, hydroxyproline, phosphoserine analogs and 
       phosphotyrosine analogs

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is absent, G, or D

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is absent, L or K

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is absent, S, T or K

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is absent or comprises a transduction domain

<400>  2

Xaa Xaa Xaa Xaa Xaa Ala Xaa Ala Pro Leu Pro Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  3
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is S, T, Y, D E, a phosphoserine mimic, or a phosphotyrosine 
       mimic

<400>  3

Ala Xaa Ala Pro Leu Pro 
1               5       


<210>  4
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  Residues are optionally absent

<400>  4

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  5
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  6
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Ala Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10          


<210>  7
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

Asp Ala Ala Thr Ala Thr Arg Gly Arg Ser Ala Ala Ser Arg Pro Thr 
1               5                   10                  15      


Glu Arg Pro Arg Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Pro 
            20                  25                  30          


Val Glu 
        


<210>  8
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  8

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Leu Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  9
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  9

Pro Leu Ser Ser Ile Phe Ser Arg Ile Gly Asp Pro 
1               5                   10          


<210>  10
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  11
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  11

Ala Ala Val Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10          


<210>  12
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Val Thr Val Leu Ala Leu Gly Ala Leu Ala Gly Val Gly Val Gly 
1               5                   10                  15  


<210>  13
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro 
            20      


<210>  14
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Leu Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  15
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  15

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  16
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  17
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  17

Lys Ala Phe Ala Lys Leu Ala Ala Arg Leu Tyr Arg Lys Ala Gly Cys 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Lys Ala Phe Ala Lys Leu Ala Ala Arg Leu Tyr Arg Ala Ala Gly Cys 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  19

Ala Ala Phe Ala Lys Leu Ala Ala Arg Leu Tyr Arg Lys Ala Gly Cys 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  20

Lys Ala Phe Ala Ala Leu Ala Ala Arg Leu Tyr Arg Lys Ala Gly Cys 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  21

Lys Ala Phe Ala Lys Leu Ala Ala Gln Leu Tyr Arg Lys Ala Gly Cys 
1               5                   10                  15      


<210>  22
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  22

Ala Gly Gly Gly Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10                  15      


<210>  23
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  23

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  24
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  24

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  25

Trp Leu Arg Arg Ile Lys Ala 
1               5           


<210>  26
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  26

Trp Leu Arg Arg Ile Lys Ala Trp Leu Arg Arg Ile Lys Ala 
1               5                   10                  


<210>  27
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  27

Trp Leu Arg Arg Ile Lys Ala Trp Leu Arg Arg Ile Lys Ala Trp Leu 
1               5                   10                  15      


Arg Arg Ile Lys Ala 
            20      


<210>  28
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  S is phosphorylated

<400>  28

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala Trp Leu Arg Arg Ala 
1               5                   10                  15      


Ser Ala Pro Leu Pro Gly Leu Lys 
            20                  


<210>  29
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  S is phosphorylated

<400>  29

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Trp Leu Arg Arg Ala 
1               5                   10                  15      


Ser Ala Pro Leu Pro Gly Leu Lys 
            20                  


<210>  30
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  S is phosphorylated

<400>  30

Trp Leu Arg Arg Ile Lys Ala Trp Leu Arg Arg Ala Ser Ala Pro Leu 
1               5                   10                  15      


Pro Gly Leu Lys 
            20  


<210>  31
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  S is phosphorylated

<400>  31

Trp Leu Arg Arg Ile Lys Ala Trp Leu Arg Arg Ile Lys Ala Trp Leu 
1               5                   10                  15      


Arg Arg Ala Ser Ala Pro Leu Pro Gly Leu Lys 
            20                  25          


<210>  32
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  S is phosphorylated

<400>  32

Trp Leu Arg Arg Ile Lys Ala Trp Leu Arg Arg Ile Lys Ala Trp Leu 
1               5                   10                  15      


Arg Arg Ile Lys Ala Trp Leu Arg Arg Ala Ser Ala Pro Leu Pro Gly 
            20                  25                  30          


Leu Lys 
        


<210>  33
<211>  162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is absent or a transduction domain

<220>
<221>  MISC_FEATURE
<222>  (2)..(15)
<223>  residues are optionally absent

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is selected from the group consisting of S, T, Y, D, E, 
       hydroxylysine, hydroxyproline, phosphoserine analogs and 
       phosphotyrosine analogs

<220>
<221>  MISC_FEATURE
<222>  (22)..(161)
<223>  Residues are optionally absent

<220>
<221>  MISC_FEATURE
<222>  (162)..(162)
<223>  X is absent or a transduction domain

<400>  33

Xaa Met Glu Ile Pro Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala 
1               5                   10                  15      


Xaa Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln 
            20                  25                  30          


Arg Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro 
        35                  40                  45              


Thr Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro 
    50                  55                  60                  


Val Ala Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp 
65                  70                  75                  80  


Val Lys His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu 
                85                  90                  95      


His Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly 
            100                 105                 110         


Phe Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val 
        115                 120                 125             


Asp Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser 
    130                 135                 140                 


Ile Gln Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala 
145                 150                 155                 160 


Lys Xaa 
        


<210>  34
<211>  160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  34

Met Glu Ile Pro Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala Ser 
1               5                   10                  15      


Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln Arg 
            20                  25                  30          


Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro Thr 
        35                  40                  45              


Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro Val 
    50                  55                  60                  


Ala Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp Val 
65                  70                  75                  80  


Lys His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu His 
                85                  90                  95      


Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly Phe 
            100                 105                 110         


Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val Asp 
        115                 120                 125             


Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser Ile 
    130                 135                 140                 


Gln Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala Lys 
145                 150                 155                 160 


<210>  35
<211>  162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is absent or transduction domain

<220>
<221>  MISC_FEATURE
<222>  (162)..(162)
<223>  X is absent or transduction domain

<400>  35

Xaa Met Glu Ile Pro Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala 
1               5                   10                  15      


Ser Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln 
            20                  25                  30          


Arg Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro 
        35                  40                  45              


Thr Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro 
    50                  55                  60                  


Val Ala Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp 
65                  70                  75                  80  


Val Lys His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu 
                85                  90                  95      


His Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly 
            100                 105                 110         


Phe Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val 
        115                 120                 125             


Asp Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser 
    130                 135                 140                 


Ile Gln Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala 
145                 150                 155                 160 


Lys Xaa 
        


<210>  36
<211>  160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  36

Met Glu Ile Pro Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala Asp 
1               5                   10                  15      


Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln Arg 
            20                  25                  30          


Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro Thr 
        35                  40                  45              


Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro Val 
    50                  55                  60                  


Ala Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp Val 
65                  70                  75                  80  


Lys His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu His 
                85                  90                  95      


Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly Phe 
            100                 105                 110         


Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val Asp 
        115                 120                 125             


Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser Ile 
    130                 135                 140                 


Gln Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala Lys 
145                 150                 155                 160 


<210>  37
<211>  162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is absent or a transduction domain

<220>
<221>  MISC_FEATURE
<222>  (162)..(162)
<223>  X is absent or a transduction domain

<400>  37

Xaa Met Glu Ile Pro Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala 
1               5                   10                  15      


Asp Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln 
            20                  25                  30          


Arg Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro 
        35                  40                  45              


Thr Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro 
    50                  55                  60                  


Val Ala Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp 
65                  70                  75                  80  


Val Lys His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu 
                85                  90                  95      


His Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly 
            100                 105                 110         


Phe Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val 
        115                 120                 125             


Asp Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser 
    130                 135                 140                 


Ile Gln Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala 
145                 150                 155                 160 


Lys Xaa 
        


<210>  38
<211>  160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  38

Met Glu Ile Pro Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala Glu 
1               5                   10                  15      


Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln Arg 
            20                  25                  30          


Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro Thr 
        35                  40                  45              


Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro Val 
    50                  55                  60                  


Ala Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp Val 
65                  70                  75                  80  


Lys His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu His 
                85                  90                  95      


Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly Phe 
            100                 105                 110         


Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val Asp 
        115                 120                 125             


Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser Ile 
    130                 135                 140                 


Gln Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala Lys 
145                 150                 155                 160 


<210>  39
<211>  162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is absent or transducation domain

<220>
<221>  MISC_FEATURE
<222>  (162)..(162)
<223>  X is absent or transducation domain

<400>  39

Xaa Met Glu Ile Pro Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala 
1               5                   10                  15      


Glu Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln 
            20                  25                  30          


Arg Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro 
        35                  40                  45              


Thr Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro 
    50                  55                  60                  


Val Ala Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp 
65                  70                  75                  80  


Val Lys His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu 
                85                  90                  95      


His Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly 
            100                 105                 110         


Phe Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val 
        115                 120                 125             


Asp Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser 
    130                 135                 140                 


Ile Gln Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala 
145                 150                 155                 160 


Lys Xaa 
        


<210>  40
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  S is optionally phosphorylated

<400>  40

Trp Leu Arg Arg Ala Ser Ala Pro Leu Pro Gly Leu Lys 
1               5                   10              


<210>  41
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is absent or transduction domain

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  S is optionally phosphorylated

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is absent or transduction domain

<400>  41

Xaa Trp Leu Arg Arg Ala Ser Ala Pro Leu Pro Gly Leu Lys Xaa 
1               5                   10                  15  


<210>  42
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  42

Trp Leu Arg Arg Ala Asp Ala Pro Leu Pro Gly Leu Lys 
1               5                   10              


<210>  43
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is absent or a transduction domain

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is absent or a transduction domain

<400>  43

Xaa Trp Leu Arg Arg Ala Asp Ala Pro Leu Pro Gly Leu Lys Xaa 
1               5                   10                  15  


<210>  44
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  44

Trp Leu Arg Arg Ala Glu Ala Pro Leu Pro Gly Leu Lys 
1               5                   10              


<210>  45
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is absent or a transduction domain

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is absent or a transduction domain

<400>  45

Xaa Trp Leu Arg Arg Ala Glu Ala Pro Leu Pro Gly Leu Lys Xaa 
1               5                   10                  15  


<210>  46
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  46

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala Trp Leu Arg Arg Ala 
1               5                   10                  15      


Ala Ala Pro Leu Pro Gly Leu Lys 
            20                  


<210>  47
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  S is optionally phosphorylated

<400>  47

Trp Leu Arg Arg Ala Ser Ala Pro Leu Pro Gly Leu Lys 
1               5                   10              


