
                                SEQUENCE LISTING

<110> Joslin Diabetes Center, Inc.

<120> METHODS OF TREATING DIABETES
  

<130> 10276-094WO2

<150> US 11/653,594       
<151> 2007-01-16  

<150> US 60/624,928       
<151> 2004-11-04  

<160> 16

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 1
aaguggagga gcuguuguac a                                           21

<210> 2
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 2
aagcgacgga acaagaugac a                                           21

<210> 3
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 3
aaaggcugca gguaacuagu u                                           21

<210> 4
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 4
aagaccaaca acuucuaaga g                                           21

<210> 5
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 5
aagcacacag aacuggauau g                                           21

<210> 6
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated siRNA

<400> 6
aaccuucagu gcuaugucuc u                                           21

<210> 7
<211> 4846
<212> DNA
<213> Homo sapiens

<400> 7
atcttggatt ccgcggtagc ggaggcggcg gtcaggcgcc gcttctgggg agtggccttt 60
cttttcccct ccctcccggt tcggtggcgg cggctcctcc cactgggggg gggggtggcg 120
cggcggcggt ggcatctgcg gccatggcgg cgactactgc caaccccgaa atgacatcag 180
atgtaccatc actgggtcca gccattgcct ctggaaactc tggacctgga attcaaggtg 240
gaggagccat tgtccagagg gctattaagc ggcgaccagg gctggatttt gatgatgatg 300
gagaagggaa cagtaaattt ttgaggtgtg atgatgatca gatgtctaac gataaggagc 360
ggtttgccag gtcggatgat gagcagagct ctgcggataa agagagactt gccagggaaa 420
atcacagtga aattgaacgg cggcgacgga acaagatgac agcctacatc acagaactgt 480
cagatatggt acccacctgt agtgccctgg ctcgaaaacc agacaagcta accatcttac 540
gcatggcagt ttctcacatg aagtccttgc ggggaactgg caacacatcc actgatggct 600
cctataagcc gtctttcctc actgatcagg aactgaaaca tttgatcttg gaggcagcag 660
atggctttct gtttattgtc tcatgtgaga caggcagggt ggtgtatgtg tctgactccg 720
tgactcctgt tttgaaccag ccacagtctg aatggtttgg cagcacactc tatgatcagg 780
tgcacccaga tgatgtggat aaacttcgtg agcagctttc cacttcagaa aatgccctga 840
cagggcgtat cctggatcta aagactggaa cagtgaaaaa ggaaggtcag cagtcttcca 900
tgagaatgtg tatgggctca aggagatcgt ttatttgccg aatgaggtgt ggcagtagct 960
ctgtggaccc agtttctgtg aataggctga gctttgtgag gaacagatgc aggaatggac 1020
ttggctctgt aaaggatggg gaacctcact tcgtggtggt ccactgcaca ggctacatca 1080
aggcctggcc cccagcaggt gtttccctcc cagatgatga cccagaggct ggccagggaa 1140
gcaagttttg cctagtggcc attggcagat tgcaggtaac tagttctccc aactgtacag 1200
acatgagtaa tgtttgtcaa ccaacagagt tcatctcccg acacaacatt gagggtatct 1260
tcacttttgt ggatcaccgc tgtgtggcta ctgttggcta ccagccacag gaactcttag 1320
gaaagaatat tgtagaattc tgtcatcctg aagaccagca gcttctaaga gacagcttcc 1380
aacaggtagt gaaattaaaa ggccaagtgc tgtctgtcat gttccggttc cggtctaaga 1440
accaagaatg gctctggatg agaaccagct cctttacttt ccagaaccct tactcagatg 1500
aaattgagta catcatctgt accaacacca atgtgaagaa ctctagccaa gaaccacggc 1560
ctacactctc caacacaatc cagaggccac aactaggtcc cacagctaat ttacccctgg 1620
agatgggctc aggacagctg gcacccaggc agcagcaaca gcaaacagaa ttggacatgg 1680
taccaggaag agatggactg gccagctaca atcattccca ggtggttcag cctgtgacaa 1740
ccacaggacc agaacacagc aagccccttg agaagtcaga tggtttattt gcccaggata 1800
gagatccaag attttcagaa atctatcaca acatcaatgc ggatcagagt aaaggcatct 1860
cctccagcac tgtccctgcc acccaacagc tattctccca gggcaacaca ttccctccta 1920
ccccccggcc ggcagagaat ttcaggaata gtggcctagc ccctcctgta accattgtcc 1980
agccatcagc ttctgcagga cagatgttgg cccagatttc ccgccactcc aaccccaccc 2040
aaggagcaac cccaacttgg acccctacta cccgctcagg cttttctgcc cagcaggtgg 2100
ctacccaggc tactgctaag actcgtactt cccagtttgg tgtgggcagc tttcagactc 2160
catcctcctt cagctccatg tccctccctg gtgccccaac tgcatcgcct ggtgctgctg 2220
cctaccctag tctcaccaat cgtggatcta actttgctcc tgagactgga cagactgcag 2280
gacaattcca gacacggaca gcagagggtg tgggtgtctg gccacagtgg cagggccagc 2340
agcctcatca tcgttcaagt tctagtgagc aacatgttca acaaccgcca gcacagcaac 2400
ctggccagcc tgaggtcttc caggagatgc tgtccatgct gggagatcag agcaacagct 2460
acaacaatga agaattccct gatctaacta tgtttccccc cttttcagaa tagaactatt 2520
ggggtgagga taaggggtgg gggagaaaaa atcactgttt gtttttaaaa agcaaatctt 2580
tctgtaaaca gaataaaagt tcctctccct tcccttccct cacccctgac atgtaccccc 2640
tttcccttct ggctgttccc ctgctctgtt gcctctctaa ggtaacattt atagaagaaa 2700
tggaatgaat ctccaaggct tttaggactg tctgaaaatt tgaggctggg tgaagttaaa 2760
acacctttcc ttatgtctcc tgacctgaaa ttgtatagtg ttgatttgtg ctgagatcaa 2820
gaggcaggtt agaagaacct gacatccact gtttgccttg gatagtatgg cttgtttttg 2880
gaaagaaatt ctgaagagag tggaggagag gagaaatgtc ctcatatttg aggaccatga 2940
aacattgtag gtatatatgg ggctttagca agtttgagca taggctcttt ttgctgcctg 3000
tgagcagtcc ctctggaaag aaacatgtga gtaagtgaga gagagtgtgt gtgtatgtgt 3060
gtgtgtgtgt gtgtgcgcac acatgcttct gtatttcact ctttctccct attagggagt 3120
tatgcaaaat ttgtccccga ttttaccttt gtctttctgt gtacttttca aagagtccta 3180
aggagttaaa tcttccaggt attttccact tagtattgca gccaaagaat atttaaataa 3240
acgtctttgc tgcgcttgca tccatgccca gccaatatac aactgtaaag caaatataga 3300
aagtcggctg ttgatacgat tgtctgttat cgaacacatt cagtgataaa gctgggttac 3360
tgctgctttt ggtgctctca ccttatctgg aagatctgca aacattacct aaataggctg 3420
gcaagataaa cactttctgg aacccgagac ttggccataa agataatgct gcatttttct 3480
gtcagaatca catatgatgt gtgttctgta gaggttattt ctgcatggaa actcaacttc 3540
ttggattagc cgtcccagtg aaaatcctca ttgttggagt gtaaaccaaa tacgaagccc 3600
tcttgcaaag tagcctcttt catcccatac tcaaaatacc cagtttagca agcaactgag 3660
atttaagtct ctctggccct aagaggtttt tcctctttgc tccctccaat cttgagattg 3720
ggttttgctt tagagtgcaa gtatcataat tccgtatgat agatggggcc tggacaccca 3780
tctcaacagg gtcacttggt aattaacaat agccatataa atgcggatac aggttactac 3840
cctcaccctt taccttcctc aggtaacagt cgtagatacc agcttttttt tttttttttt 3900
taaattggct ttggccagta gctaaagtgc aagactgaat taatgagaag atatattaaa 3960
tgtagtcata ggggactgag gagcaagggt ggccttgaag aggccaaagg aatgtccatt 4020
tgctgagttt cccttcctta tgtctccagt ctggtgccag gtagtggagt aaaaaaggag 4080
acagtttatt tttttattct atgtgcacac ttacagtata catatatatt tatatcacaa 4140
tttacgaaac caaaaagttg agtttccaat ggaacccttg ttttttaata atcgactttt 4200
taaatgtgat caggactata atattgtaca gttattatag ggcttttggg gaaggggagg 4260
atagcgagaa gatgctctgg gggttttgtt tttgcttttc cttcagggtt ttatttttga 4320
ctgttttgtt ttcttgttgg ccatttctgt attgctggca tctgtgctaa gctttacagt 4380
ggcaaaaata atgacatgta gcaaagattt tcaaacaaaa tattttttcc ttttgtaaaa 4440
tttcttgtgt tgtgtgatct tgattgcggc tttatcattc ctttccagtt cataaacaac 4500
aggcacccac aaccagagga atctatagtt taagctccag acatacaaac ataaggcaca 4560
ttgtgtcttt aatttcagga atcagaaatc atagggttct gatcacattg cacgcctccc 4620
ccctcacttg tcctcctgat cctgacacat tctgagtaac atcagcagga atgctctgac 4680
catgaggtgg gggttttggg gtgggcgttg cctgggttct tgggagagag gggaagagtc 4740
gggacttgaa aaccactagg gcacatctgg atgccttccc ccagtatgtc cttttctgga 4800
ttaaaatgag tgaaatttaa actgaaaaaa aaaaaaaaaa aaaaaa                4846

<210> 8
<211> 789
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Ala Thr Thr Ala Asn Pro Glu Met Thr Ser Asp Val Pro Ser
 1               5                  10                  15      
Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly
            20                  25                  30          
Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp
        35                  40                  45              
Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp
    50                  55                  60                  
Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Ser Asp Asp Glu
65                  70                  75                  80  
Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala Arg Glu Asn His Ser Glu
                85                  90                  95      
Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Ala Tyr Ile Thr Glu Leu
            100                 105                 110         
Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys
        115                 120                 125             
Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly
    130                 135                 140                 
Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr Lys Pro Ser Phe Leu Thr
145                 150                 155                 160 
Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu
                165                 170                 175     
Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp Ser
            180                 185                 190         
Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Thr
        195                 200                 205             
Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln
    210                 215                 220                 
Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg Ile Leu Asp Leu Lys
225                 230                 235                 240 
Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys
                245                 250                 255     
Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser Ser
            260                 265                 270         
Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn Arg
        275                 280                 285             
Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe Val
    290                 295                 300                 
Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val
305                 310                 315                 320 
Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe Cys
                325                 330                 335     
Leu Val Ala Ile Gly Arg Leu Gln Val Thr Ser Ser Pro Asn Cys Thr
            340                 345                 350         
Asp Met Ser Asn Val Cys Gln Pro Thr Glu Phe Ile Ser Arg His Asn
        355                 360                 365             
Ile Glu Gly Ile Phe Thr Phe Val Asp His Arg Cys Val Ala Thr Val
    370                 375                 380                 
Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe Cys
385                 390                 395                 400 
His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val Val
                405                 410                 415     
Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ser Lys
            420                 425                 430         
Asn Gln Glu Trp Leu Trp Met Arg Thr Ser Ser Phe Thr Phe Gln Asn
        435                 440                 445             
Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Thr Asn Thr Asn Val
    450                 455                 460                 
Lys Asn Ser Ser Gln Glu Pro Arg Pro Thr Leu Ser Asn Thr Ile Gln
465                 470                 475                 480 
Arg Pro Gln Leu Gly Pro Thr Ala Asn Leu Pro Leu Glu Met Gly Ser
                485                 490                 495     
Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Thr Glu Leu Asp Met
            500                 505                 510         
Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln Val Val
        515                 520                 525             
Gln Pro Val Thr Thr Thr Gly Pro Glu His Ser Lys Pro Leu Glu Lys
    530                 535                 540                 
Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser Glu Ile
545                 550                 555                 560 
Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser Ser Thr
                565                 570                 575     
Val Pro Ala Thr Gln Gln Leu Phe Ser Gln Gly Asn Thr Phe Pro Pro
            580                 585                 590         
Thr Pro Arg Pro Ala Glu Asn Phe Arg Asn Ser Gly Leu Ala Pro Pro
        595                 600                 605             
Val Thr Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu Ala Gln
    610                 615                 620                 
Ile Ser Arg His Ser Asn Pro Thr Gln Gly Ala Thr Pro Thr Trp Thr
625                 630                 635                 640 
Pro Thr Thr Arg Ser Gly Phe Ser Ala Gln Gln Val Ala Thr Gln Ala
                645                 650                 655     
Thr Ala Lys Thr Arg Thr Ser Gln Phe Gly Val Gly Ser Phe Gln Thr
            660                 665                 670         
Pro Ser Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Thr Ala Ser
        675                 680                 685             
Pro Gly Ala Ala Ala Tyr Pro Ser Leu Thr Asn Arg Gly Ser Asn Phe
    690                 695                 700                 
Ala Pro Glu Thr Gly Gln Thr Ala Gly Gln Phe Gln Thr Arg Thr Ala
705                 710                 715                 720 
Glu Gly Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro His His
                725                 730                 735     
Arg Ser Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala Gln Gln
            740                 745                 750         
Pro Gly Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly Asp
        755                 760                 765             
Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Thr Met Phe
    770                 775                 780                 
Pro Pro Phe Ser Glu
785                 


<210> 9
<211> 3958
<212> DNA
<213> Homo sapiens

<400> 9
gtgctgcctc gtctgagggg acaggaggat caccctcttc gtcgcttcgg ccagtgtgtc 60
gggctgggcc ctgacaagcc acctgaggag aggctcggag ccgggcccgg accccggcga 120
ttgccgcccg cttctctcta gtctcacgag gggtttcccg cctcgcaccc ccacctctgg 180
acttgccttt ccttctcttc tccgcgtgtg gagggagcca gcgcttaggc cggagcgagc 240
ctgggggccg cccgccgtga agacatcgcg gggaccgatt caccatggag ggcgccggcg 300
gcgcgaacga caagaaaaag ataagttctg aacgtcgaaa agaaaagtct cgagatgcag 360
ccagatctcg gcgaagtaaa gaatctgaag ttttttatga gcttgctcat cagttgccac 420
ttccacataa tgtgagttcg catcttgata aggcctctgt gatgaggctt accatcagct 480
atttgcgtgt gaggaaactt ctggatgctg gtgatttgga tattgaagat gacatgaaag 540
cacagatgaa ttgcttttat ttgaaagcct tggatggttt tgttatggtt ctcacagatg 600
atggtgacat gatttacatt tctgataatg tgaacaaata catgggatta actcagtttg 660
aactaactgg acacagtgtg tttgatttta ctcatccatg tgaccatgag gaaatgagag 720
aaatgcttac acacagaaat ggccttgtga aaaagggtaa agaacaaaac acacagcgaa 780
gcttttttct cagaatgaag tgtaccctaa ctagccgagg aagaactatg aacataaagt 840
ctgcaacatg gaaggtattg cactgcacag gccacattca cgtatatgat accaacagta 900
accaacctca gtgtgggtat aagaaaccac ctatgacctg cttggtgctg atttgtgaac 960
ccattcctca cccatcaaat attgaaattc ctttagatag caagactttc ctcagtcgac 1020
acagcctgga tatgaaattt tcttattgtg atgaaagaat taccgaattg atgggatatg 1080
agccagaaga acttttaggc cgctcaattt atgaatatta tcatgctttg gactctgatc 1140
atctgaccaa aactcatcat gatatgttta ctaaaggaca agtcaccaca ggacagtaca 1200
ggatgcttgc caaaagaggt ggatatgtct gggttgaaac tcaagcaact gtcatatata 1260
acaccaagaa ttctcaacca cagtgcattg tatgtgtgaa ttacgttgtg agtggtatta 1320
ttcagcacga cttgattttc tcccttcaac aaacagaatg tgtccttaaa ccggttgaat 1380
cttcagatat gaaaatgact cagctattca ccaaagttga atcagaagat acaagtagcc 1440
tctttgacaa acttaagaag gaacctgatg ctttaacttt gctggcccca gccgctggag 1500
acacaatcat atctttagat tttggcagca acgacacaga aactgatgac cagcaacttg 1560
aggaagtacc attatataat gatgtaatgc tcccctcacc caacgaaaaa ttacagaata 1620
taaatttggc aatgtctcca ttacccaccg ctgaaacgcc aaagccactt cgaagtagtg 1680
ctgaccctgc actcaatcaa gaagttgcat taaaattaga accaaatcca gagtcactgg 1740
aactttcttt taccatgccc cagattcagg atcagacacc tagtccttcc gatggaagca 1800
ctagacaaag ttcacctgag cctaatagtc ccagtgaata ttgtttttat gtggatagtg 1860
atatggtcaa tgaattcaag ttggaattgg tagaaaaact ttttgctgaa gacacagaag 1920
caaagaaccc attttctact caggacacag atttagactt ggagatgtta gctccctata 1980
tcccaatgga tgatgacttc cagttacgtt ccttcgatca gttgtcacca ttagaaagca 2040
gttccgcaag ccctgaaagc gcaagtcctc aaagcacagt tacagtattc cagcagactc 2100
aaatacaaga acctactgct aatgccacca ctaccactgc caccactgat gaattaaaaa 2160
cagtgacaaa agaccgtatg gaagacatta aaatattgat tgcatctcca tctcctaccc 2220
acatacataa agaaactact agtgccacat catcaccata tagagatact caaagtcgga 2280
cagcctcacc aaacagagca ggaaaaggag tcatagaaca gacagaaaaa tctcatccaa 2340
gaagccctaa cgtgttatct gtcgctttga gtcaaagaac tacagttcct gaggaagaac 2400
taaatccaaa gatactagct ttgcagaatg ctcagagaaa gcgaaaaatg gaacatgatg 2460
gttcactttt tcaagcagta ggaattggaa cattattaca gcagccagac gatcatgcag 2520
ctactacatc actttcttgg aaacgtgtaa aaggatgcaa atctagtgaa cagaatggaa 2580
tggagcaaaa gacaattatt ttaataccct ctgatttagc atgtagactg ctggggcaat 2640
caatggatga aagtggatta ccacagctga ccagttatga ttgtgaagtt aatgctccta 2700
tacaaggcag cagaaaccta ctgcagggtg aagaattact cagagctttg gatcaagtta 2760
actgagcttt ttcttaattt cattcctttt tttggacact ggtggctcac tacctaaagc 2820
agtctattta tattttctac atctaatttt agaagcctgg ctacaatact gcacaaactt 2880
ggttagttca atttttgatc ccctttctac ttaatttaca ttaatgctct tttttagtat 2940
gttctttaat gctggatcac agacagctca ttttctcagt tttttggtat ttaaaccatt 3000
gcattgcagt agcatcattt taaaaaatgc acctttttat ttatttattt ttggctaggg 3060
agtttatccc tttttcgaat tatttttaag aagatgccaa tataattttt gtaagaaggc 3120
agtaaccttt catcatgatc ataggcagtt gaaaaatttt tacacctttt ttttcacatt 3180
ttacataaat aataatgctt tgccagcagt acgtggtagc cacaattgca caatatattt 3240
tcttaaaaaa taccagcagt tactcatgga atatattctg cgtttataaa actagttttt 3300
aagaagaaat tttttttggc ctatgaaatt gttaaacctg gaacatgaca ttgttaatca 3360
tataataatg attcttaaat gctgtatggt ttattattta aatgggtaaa gccatttaca 3420
taatatagaa agatatgcat atatctagaa ggtatgtggc atttatttgg ataaaattct 3480
caattcagag aaatcatctg atgtttctat agtcactttg ccagctcaaa agaaaacaat 3540
accctatgta gttgtggaag tttatgctaa tattgtgtaa ctgatattaa acctaaatgt 3600
tctgcctacc ctgttggtat aaagatattt tgagcagact gtaaacaaga aaaaaaaaat 3660
catgcattct tagcaaaatt gcctagtatg ttaatttgct caaaatacaa tgtttgattt 3720
tatgcacttt gtcgctatta acatcctttt tttcatgtag atttcaataa ttgagtaatt 3780
ttagaagcat tattttagga atatatagtt gtcacagtaa atatcttgtt ttttctatgt 3840
acattgtaca aatttttcat tccttttgct ctttgtggtt ggatctaaca ctaactgtat 3900
tgttttgtta catcaaataa acatcttctg tggaccagga aaaaaaaaaa aaaaaaaa   3958

<210> 10
<211> 825
<212> PRT
<213> Homo sapiens

<400> 10
Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu
 1               5                  10                  15      
Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys
            20                  25                  30          
Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His
        35                  40                  45              
Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile
    50                  55                  60                  
Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile
65                  70                  75                  80  
Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu
                85                  90                  95      
Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile
            100                 105                 110         
Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr
        115                 120                 125             
Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met
    130                 135                 140                 
Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu
145                 150                 155                 160 
Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr
                165                 170                 175     
Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu
            180                 185                 190         
His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro
        195                 200                 205             
Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys
    210                 215                 220                 
Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys
225                 230                 235                 240 
Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp
                245                 250                 255     
Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly
            260                 265                 270         
Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr
        275                 280                 285             
Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln
    290                 295                 300                 
Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln
305                 310                 315                 320 
Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val
                325                 330                 335     
Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe
            340                 345                 350         
Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp
        355                 360                 365             
Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser
    370                 375                 380                 
Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu
385                 390                 395                 400 
Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn
                405                 410                 415     
Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn
            420                 425                 430         
Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu
        435                 440                 445             
Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser
    450                 455                 460                 
Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro
465                 470                 475                 480 
Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp
                485                 490                 495     
Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu
            500                 505                 510         
Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val
        515                 520                 525             
Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr
    530                 535                 540                 
Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu
545                 550                 555                 560 
Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser
                565                 570                 575     
Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser
            580                 585                 590         
Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln
        595                 600                 605             
Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu
    610                 615                 620                 
Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala
625                 630                 635                 640 
Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser
                645                 650                 655     
Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala
            660                 665                 670         
Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro
        675                 680                 685             
Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu
    690                 695                 700                 
Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg
705                 710                 715                 720 
Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Gly Thr
                725                 730                 735     
Leu Leu Gln Gln Pro Asp Asp His Ala Ala Thr Thr Ser Leu Ser Trp
            740                 745                 750         
Lys Arg Val Lys Gly Cys Lys Ser Ser Glu Gln Asn Gly Met Glu Gln
        755                 760                 765             
Lys Thr Ile Ile Leu Ile Pro Ser Asp Leu Ala Cys Arg Leu Leu Gly
    770                 775                 780                 
Gln Ser Met Asp Glu Ser Gly Leu Pro Gln Leu Thr Ser Tyr Cys Glu
785                 790                 795                 800 
Val Asn Ala Pro Ile Gln Gly Ser Arg Asn Leu Leu Gln Gly Glu Glu
                805                 810                 815     
Leu Leu Arg Ala Leu Asp Gln Val Asn
            820                 825 


<210> 11
<211> 3812
<212> DNA
<213> Homo sapiens

<400> 11
gtgctgcctc gtctgagggg acaggaggat caccctcttc gtcgcttcgg ccagtgtgtc 60
gggctgggcc ctgacaagcc acctgaggag aggctcggag ccgggcccgg accccggcga 120
ttgccgcccg cttctctcta gtctcacgag gggtttcccg cctcgcaccc ccacctctgg 180
acttgccttt ccttctcttc tccgcgtgtg gagggagcca gcgcttaggc cggagcgagc 240
ctgggggccg cccgccgtga agacatcgcg gggaccgatt caccatggag ggcgccggcg 300
gcgcgaacga caagaaaaag ataagttctg aacgtcgaaa agaaaagtct cgagatgcag 360
ccagatctcg gcgaagtaaa gaatctgaag ttttttatga gcttgctcat cagttgccac 420
ttccacataa tgtgagttcg catcttgata aggcctctgt gatgaggctt accatcagct 480
atttgcgtgt gaggaaactt ctggatgctg gtgatttgga tattgaagat gacatgaaag 540
cacagatgaa ttgcttttat ttgaaagcct tggatggttt tgttatggtt ctcacagatg 600
atggtgacat gatttacatt tctgataatg tgaacaaata catgggatta actcagtttg 660
aactaactgg acacagtgtg tttgatttta ctcatccatg tgaccatgag gaaatgagag 720
aaatgcttac acacagaaat ggccttgtga aaaagggtaa agaacaaaac acacagcgaa 780
gcttttttct cagaatgaag tgtaccctaa ctagccgagg aagaactatg aacataaagt 840
ctgcaacatg gaaggtattg cactgcacag gccacattca cgtatatgat accaacagta 900
accaacctca gtgtgggtat aagaaaccac ctatgacctg cttggtgctg atttgtgaac 960
ccattcctca cccatcaaat attgaaattc ctttagatag caagactttc ctcagtcgac 1020
acagcctgga tatgaaattt tcttattgtg atgaaagaat taccgaattg atgggatatg 1080
agccagaaga acttttaggc cgctcaattt atgaatatta tcatgctttg gactctgatc 1140
atctgaccaa aactcatcat gatatgttta ctaaaggaca agtcaccaca ggacagtaca 1200
ggatgcttgc caaaagaggt ggatatgtct gggttgaaac tcaagcaact gtcatatata 1260
acaccaagaa ttctcaacca cagtgcattg tatgtgtgaa ttacgttgtg agtggtatta 1320
ttcagcacga cttgattttc tcccttcaac aaacagaatg tgtccttaaa ccggttgaat 1380
cttcagatat gaaaatgact cagctattca ccaaagttga atcagaagat acaagtagcc 1440
tctttgacaa acttaagaag gaacctgatg ctttaacttt gctggcccca gccgctggag 1500
acacaatcat atctttagat tttggcagca acgacacaga aactgatgac cagcaacttg 1560
aggaagtacc attatataat gatgtaatgc tcccctcacc caacgaaaaa ttacagaata 1620
taaatttggc aatgtctcca ttacccaccg ctgaaacgcc aaagccactt cgaagtagtg 1680
ctgaccctgc actcaatcaa gaagttgcat taaaattaga accaaatcca gagtcactgg 1740
aactttcttt taccatgccc cagattcagg atcagacacc tagtccttcc gatggaagca 1800
ctagacaaag ttcacctgag cctaatagtc ccagtgaata ttgtttttat gtggatagtg 1860
atatggtcaa tgaattcaag ttggaattgg tagaaaaact ttttgctgaa gacacagaag 1920
caaagaaccc attttctact caggacacag atttagactt ggagatgtta gctccctata 1980
tcccaatgga tgatgacttc cagttacgtt ccttcgatca gttgtcacca ttagaaagca 2040
gttccgcaag ccctgaaagc gcaagtcctc aaagcacagt tacagtattc cagcagactc 2100
aaatacaaga acctactgct aatgccacca ctaccactgc caccactgat gaattaaaaa 2160
cagtgacaaa agaccgtatg gaagacatta aaatattgat tgcatctcca tctcctaccc 2220
acatacataa agaaactact agtgccacat catcaccata tagagatact caaagtcgga 2280
cagcctcacc aaacagagca ggaaaaggag tcatagaaca gacagaaaaa tctcatccaa 2340
gaagccctaa cgtgttatct gtcgctttga gtcaaagaac tacagttcct gaggaagaac 2400
taaatccaaa gatactagct ttgcagaatg ctcagagaaa gcgaaaaatg gaacatgatg 2460
gttcactttt tcaagcagta ggaattattt agcatgtaga ctgctggggc aatcaatgga 2520
tgaaagtgga ttaccacagc tgaccagtta tgattgtgaa gttaatgctc ctatacaagg 2580
cagcagaaac ctactgcagg gtgaagaatt actcagagct ttggatcaag ttaactgagc 2640
tttttcttaa tttcattcct ttttttggac actggtggct cactacctaa agcagtctat 2700
ttatattttc tacatctaat tttagaagcc tggctacaat actgcacaaa cttggttagt 2760
tcaatttttg atcccctttc tacttaattt acattaatgc tcttttttag tatgttcttt 2820
aatgctggat cacagacagc tcattttctc agttttttgg tatttaaacc attgcattgc 2880
agtagcatca ttttaaaaaa tgcacctttt tatttattta tttttggcta gggagtttat 2940
ccctttttcg aattattttt aagaagatgc caatataatt tttgtaagaa ggcagtaacc 3000
tttcatcatg atcataggca gttgaaaaat ttttacacct tttttttcac attttacata 3060
aataataatg ctttgccagc agtacgtggt agccacaatt gcacaatata ttttcttaaa 3120
aaataccagc agttactcat ggaatatatt ctgcgtttat aaaactagtt tttaagaaga 3180
aatttttttt ggcctatgaa attgttaaac ctggaacatg acattgttaa tcatataata 3240
atgattctta aatgctgtat ggtttattat ttaaatgggt aaagccattt acataatata 3300
gaaagatatg catatatcta gaaggtatgt ggcatttatt tggataaaat tctcaattca 3360
gagaaatcat ctgatgtttc tatagtcact ttgccagctc aaaagaaaac aataccctat 3420
gtagttgtgg aagtttatgc taatattgtg taactgatat taaacctaaa tgttctgcct 3480
accctgttgg tataaagata ttttgagcag actgtaaaca agaaaaaaaa aatcatgcat 3540
tcttagcaaa attgcctagt atgttaattt gctcaaaata caatgtttga ttttatgcac 3600
tttgtcgcta ttaacatcct ttttttcatg tagatttcaa taattgagta attttagaag 3660
cattatttta ggaatatata gttgtcacag taaatatctt gttttttcta tgtacattgt 3720
acaaattttt cattcctttt gctctttgtg gttggatcta acactaactg tattgttttg 3780
ttacatcaaa taaacatctt ctgtggacca gg                               3812

<210> 12
<211> 735
<212> PRT
<213> Homo sapiens

<400> 12
Met Glu Gly Ala Gly Gly Ala Asn Asp Lys Lys Lys Ile Ser Ser Glu
 1               5                  10                  15      
Arg Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Lys
            20                  25                  30          
Glu Ser Glu Val Phe Tyr Glu Leu Ala His Gln Leu Pro Leu Pro His
        35                  40                  45              
Asn Val Ser Ser His Leu Asp Lys Ala Ser Val Met Arg Leu Thr Ile
    50                  55                  60                  
Ser Tyr Leu Arg Val Arg Lys Leu Leu Asp Ala Gly Asp Leu Asp Ile
65                  70                  75                  80  
Glu Asp Asp Met Lys Ala Gln Met Asn Cys Phe Tyr Leu Lys Ala Leu
                85                  90                  95      
Asp Gly Phe Val Met Val Leu Thr Asp Asp Gly Asp Met Ile Tyr Ile
            100                 105                 110         
Ser Asp Asn Val Asn Lys Tyr Met Gly Leu Thr Gln Phe Glu Leu Thr
        115                 120                 125             
Gly His Ser Val Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Met
    130                 135                 140                 
Arg Glu Met Leu Thr His Arg Asn Gly Leu Val Lys Lys Gly Lys Glu
145                 150                 155                 160 
Gln Asn Thr Gln Arg Ser Phe Phe Leu Arg Met Lys Cys Thr Leu Thr
                165                 170                 175     
Ser Arg Gly Arg Thr Met Asn Ile Lys Ser Ala Thr Trp Lys Val Leu
            180                 185                 190         
His Cys Thr Gly His Ile His Val Tyr Asp Thr Asn Ser Asn Gln Pro
        195                 200                 205             
Gln Cys Gly Tyr Lys Lys Pro Pro Met Thr Cys Leu Val Leu Ile Cys
    210                 215                 220                 
Glu Pro Ile Pro His Pro Ser Asn Ile Glu Ile Pro Leu Asp Ser Lys
225                 230                 235                 240 
Thr Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Ser Tyr Cys Asp
                245                 250                 255     
Glu Arg Ile Thr Glu Leu Met Gly Tyr Glu Pro Glu Glu Leu Leu Gly
            260                 265                 270         
Arg Ser Ile Tyr Glu Tyr Tyr His Ala Leu Asp Ser Asp His Leu Thr
        275                 280                 285             
Lys Thr His His Asp Met Phe Thr Lys Gly Gln Val Thr Thr Gly Gln
    290                 295                 300                 
Tyr Arg Met Leu Ala Lys Arg Gly Gly Tyr Val Trp Val Glu Thr Gln
305                 310                 315                 320 
Ala Thr Val Ile Tyr Asn Thr Lys Asn Ser Gln Pro Gln Cys Ile Val
                325                 330                 335     
Cys Val Asn Tyr Val Val Ser Gly Ile Ile Gln His Asp Leu Ile Phe
            340                 345                 350         
Ser Leu Gln Gln Thr Glu Cys Val Leu Lys Pro Val Glu Ser Ser Asp
        355                 360                 365             
Met Lys Met Thr Gln Leu Phe Thr Lys Val Glu Ser Glu Asp Thr Ser
    370                 375                 380                 
Ser Leu Phe Asp Lys Leu Lys Lys Glu Pro Asp Ala Leu Thr Leu Leu
385                 390                 395                 400 
Ala Pro Ala Ala Gly Asp Thr Ile Ile Ser Leu Asp Phe Gly Ser Asn
                405                 410                 415     
Asp Thr Glu Thr Asp Asp Gln Gln Leu Glu Glu Val Pro Leu Tyr Asn
            420                 425                 430         
Asp Val Met Leu Pro Ser Pro Asn Glu Lys Leu Gln Asn Ile Asn Leu
        435                 440                 445             
Ala Met Ser Pro Leu Pro Thr Ala Glu Thr Pro Lys Pro Leu Arg Ser
    450                 455                 460                 
Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys Leu Glu Pro
465                 470                 475                 480 
Asn Pro Glu Ser Leu Glu Leu Ser Phe Thr Met Pro Gln Ile Gln Asp
                485                 490                 495     
Gln Thr Pro Ser Pro Ser Asp Gly Ser Thr Arg Gln Ser Ser Pro Glu
            500                 505                 510         
Pro Asn Ser Pro Ser Glu Tyr Cys Phe Tyr Val Asp Ser Asp Met Val
        515                 520                 525             
Asn Glu Phe Lys Leu Glu Leu Val Glu Lys Leu Phe Ala Glu Asp Thr
    530                 535                 540                 
Glu Ala Lys Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu
545                 550                 555                 560 
Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser
                565                 570                 575     
Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser
            580                 585                 590         
Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Gln Thr Gln Ile Gln
        595                 600                 605             
Glu Pro Thr Ala Asn Ala Thr Thr Thr Thr Ala Thr Thr Asp Glu Leu
    610                 615                 620                 
Lys Thr Val Thr Lys Asp Arg Met Glu Asp Ile Lys Ile Leu Ile Ala
625                 630                 635                 640 
Ser Pro Ser Pro Thr His Ile His Lys Glu Thr Thr Ser Ala Thr Ser
                645                 650                 655     
Ser Pro Tyr Arg Asp Thr Gln Ser Arg Thr Ala Ser Pro Asn Arg Ala
            660                 665                 670         
Gly Lys Gly Val Ile Glu Gln Thr Glu Lys Ser His Pro Arg Ser Pro
        675                 680                 685             
Asn Val Leu Ser Val Ala Leu Ser Gln Arg Thr Thr Val Pro Glu Glu
    690                 695                 700                 
Glu Leu Asn Pro Lys Ile Leu Ala Leu Gln Asn Ala Gln Arg Lys Arg
705                 710                 715                 720 
Lys Met Glu His Asp Gly Ser Leu Phe Gln Ala Val Gly Ile Ile
                725                 730                 735 


<210> 13
<211> 5186
<212> DNA
<213> Homo sapiens

<400> 13
gccacacggg tccggtgccc gctgcgcttc cgccccagcg ctcctgaggc ggccgtacaa 60
tcctcggcag tgtcctgaga ctgtatggtc agctcagccc ggcctccgac tccttccgac 120
tcccagcatt cgagccactt ttttttttct ttgaaaactc agaaaagtga ctccttttcc 180
agggaaaaag gaacttgggt tcccttctct ccgtcctctt ttcgggtctg acagcctcca 240
cccactcctt ccccggaccc cgcctccgcg cgcaggttcc tcccagtcac ctttctccac 300
ccccgccccc gcacctagcc cgccgcgcgc caccttccac ctgactgcgc ggggcgctcg 360
ggacctgcgc gcacctcgga ccttcaccac ccgcccgggc cgcggggagc ggacgagggc 420
cacagccccc cacccgccag ggagcccagg tgctcggcgt ctgaacgtct caaagggcca 480
cagcgacaat gacagctgac aaggagaaga aaaggagtag ctcggagagg aggaaggaga 540
agtcccggga tgctgcgcgg tgccggcgga gcaaggagac ggaggtgttc tatgagctgg 600
cccatgagct gcctctgccc cacagtgtga gctcccatct ggacaaggcc tccatcatgc 660
gactggcaat cagcttcctg cgaacacaca agctcctctc ctcagtttgc tctgaaaacg 720
agtccgaagc cgaagctgac cagcagatgg acaacttgta cctgaaagcc ttggagggtt 780
tcattgccgt ggtgacccaa gatggcgaca tgatctttct gtcagaaaac atcagcaagt 840
tcatgggact tacacaggtg gagctaacag gacatagtat ctttgacttc actcatccct 900
gcgaccatga ggagattcgt gagaacctga gtctcaaaaa tggctctggt tttgggaaaa 960
aaagcaaaga catgtccaca gagcgggact tcttcatgag gatgaagtgc acggtcacca 1020
acagaggccg tactgtcaac ctcaagtcag ccacctggaa ggtcttgcac tgcacgggcc 1080
aggtgaaagt ctacaacaac tgccctcctc acaatagtct gtgtggctac aaggagcccc 1140
tgctgtcctg cctcatcatc atgtgtgaac caatccagca cccatcccac atggacatcc 1200
ccctggatag caagaccttc ctgagccgcc acagcatgga catgaagttc acctactgtg 1260
atgacagaat cacagaactg attggttacc accctgagga gctgcttggc cgctcagcct 1320
atgaattcta ccatgcgcta gactccgaga acatgaccaa gagtcaccag aacttgtgca 1380
ccaagggtca ggtagtaagt ggccagtacc ggatgctcgc aaagcatggg ggctacgtgt 1440
ggctggagac ccaggggacg gtcatctaca accctcgcaa cctgcagccc cagtgcatca 1500
tgtgtgtcaa ctacgtcctg agtgagattg agaagaatga cgtggtgttc tccatggacc 1560
agactgaatc cctgttcaag ccccacctga tggccatgaa cagcatcttt gatagcagtg 1620
gcaagggggc tgtgtctgag aagagtaact tcctattcac caagctaaag gaggagcccg 1680
aggagctggc ccagctggct cccaccccag gagacgccat catctctctg gatttcggga 1740
atcagaactt cgaggagtcc tcagcctatg gcaaggccat cctgcccccg agccagccat 1800
gggccacgga gttgaggagc cacagcaccc agagcgaggc tgggagcctg cctgccttca 1860
ccgtgcccca ggcagctgcc ccgggcagca ccacccccag tgccaccagc agcagcagca 1920
gctgctccac gcccaatagc cctgaagact attacacatc tttggataac gacctgaaga 1980
ttgaagtgat tgagaagctc ttcgccatgg acacagaggc caaggaccaa tgcagtaccc 2040
agacggattt caatgagctg gacttggaga cactggcacc ctatatcccc atggacgggg 2100
aagacttcca gctaagcccc atctgccccg aggagcggct cttggcggag aacccacagt 2160
ccacccccca gcactgcttc agtgccatga caaacatctt ccagccactg gcccctgtag 2220
ccccgcacag tcccttcctc ctggacaagt ttcagcagca gctggagagc aagaagacag 2280
agcccgagca ccggcccatg tcctccatct tctttgatgc cggaagcaaa gcatccctgc 2340
caccgtgctg tggccaggcc agcacccctc tctcttccat ggggggcaga tccaataccc 2400
agtggccccc agatccacca ttacattttg ggcccacaaa gtgggccgtc ggggatcagc 2460
gcacagagtt cttgggagca gcgccgttgg ggccccctgt ctctccaccc catgtctcca 2520
ccttcaagac aaggtctgca aagggttttg gggctcgagg cccagacgtg ctgagtccgg 2580
ccatggtagc cctctccaac aagctgaagc tgaagcgaca gctggagtat gaagagcaag 2640
ccttccagga cctgagcggg ggggacccac ctggtggcag cacctcacat ttgatgtgga 2700
aacggatgaa gaacctcagg ggtgggagct gccctttgat gccggacaag ccactgagcg 2760
caaatgtacc caatgataag ttcacccaaa accccatgag gggcctgggc catcccctga 2820
gacatctgcc gctgccacag cctccatctg ccatcagtcc cggggagaac agcaagagca 2880
ggttcccccc acagtgctac gccacccagt accaggacta cagcctgtcg tcagcccaca 2940
aggtgtcagg catggcaagc cggctgctcg ggccctcatt tgagtcctac ctgctgcccg 3000
aactgaccag atatgactgt gaggtgaacg tgcccgtgct gggaagctcc acgctcctgc 3060
aaggagggga cctcctcaga gccctggacc aggccacctg agccaggcct tctacctggg 3120
cagcacctct gccgacgccg tcccaccagc ttcactctct ccgtctgttt ttgcaactag 3180
gtatttctaa cgccagcaca ctatttacaa gatggactta cctggcagac ttgcccaggt 3240
caccaagcag tggccttttt ctgagatgct cactttatta tccctatttt taaagtacac 3300
aattgtttta cctgttctga aatgttctta aattttgtag gatttttttc ctccccacct 3360
tcaatgactt ctaatttata ttatccatag gtttctctcc ctccttctcc ttctcacaca 3420
caactgtcca tactaacaag tttggtgcat gtctgttctt ctgtagggag aagctttagc 3480
ttcattttac taaaaagatt cctcgttatt gttgttgcca aagagaaaca aaaatgattt 3540
tgctttccaa gcttggtttg tggcgtctcc ctcgcagagc ccttctcgtt tcttttttaa 3600
actaatcacc atattgtaaa tttcagggtt tttttttttt tgtttaagct gactctttgc 3660
tctaattttg gaaaaaaaga aatgtgaagg gtcaactcca acgtatgtgg ttatctgtga 3720
aagttgcaca gcgtggcttt tcctaaactg gtgtttttcc cccgcatttg gtggattttt 3780
tattattatt caaaaacata actgagtttt ttaaaagagg agaaaattta tatctgggtt 3840
aagtgtttat catatatatg ggtactttgt aatatctaaa aacttagaaa cggaaatgga 3900
atcctgctca caaaatcact ttaagatctt ttcgaagctg ttaatttttc ttagtgttgt 3960
ggacactgca gacttgtcca gtgctcccac ggcctgtacg gacactgtgg aaggcctccc 4020
tctgtcggct ttttgccatc tgtgatatgc cataggtgtg acaatccgag cagtggagtc 4080
attcagcggg agcactgcgc gctatcccct cacattctct atgtactatg tatgtatgta 4140
ttattattat tgctgccaag agggtctgat ggcacgttgt ggggtcgggg ggtggggcgg 4200
ggaagtgctc taacttttct taaggttttg ttgctagccc ttcaagtgca ctgagctatg 4260
tgactcggat ggtctttcac acggcacatt tggacatttc cagaactacc atgagatggt 4320
ttagacggga attcatgcaa atgaggggtc aaaaatggta tagtgacccc gtccacgtcc 4380
tccaagctca cgaccttgga gccccgtgga gctggactga ggaggaggct gcacagcggg 4440
agagcagctg gtccagacca gccctgcagc ccccactcag ccggcagcca gatggccccg 4500
caaggcctcc agggatggcc cctagccaca ggccctggct gaggtctctg ggtcggtcag 4560
tgacatgtag gtaggaagca ctgaaaatag tgttcccaga gcactttgca actccctggg 4620
taagagggac gacacctctg gtttttcaat accaattaca tggaactttt ctgtaatggg 4680
tacaatgaag aagtttctaa aaacacacac aaagcacatt gggccaacta tttagtaagc 4740
ccggatagac ttattgccaa aaacaaaaaa tagctttcaa aagaaattta agttctatga 4800
gaaattcctt agtcatggtg ttgcgtaaat catattttag ctgcacggca ttaccccaca 4860
cagggtggca gaacttgaag ggttactgac gtgtaaatgc tggtatttga tttcctgtgt 4920
gtgttgccct ggcattaagg gcattttacc cttgcagttt tactaaaaca ctgaaaaata 4980
ttccaagctt catattaacc ctacctgtca acgtaacgat ttcatgaacg ttattatatt 5040
gtcgaattcc tactgacaac attataactg tatgggagct taactttata aggaaatgta 5100
ttttgacact ggtatcttat taaagtattc tgatcctaaa aaaaaaaaaa aaaaaaaaaa 5160
aaaaaaaaaa aaaaaaaaaa aaaaaa                                      5186



<210> 14
<211> 870
<212> PRT
<213> Homo sapiens

<400> 14
Met Thr Ala Asp Lys Glu Lys Lys Arg Ser Ser Ser Glu Arg Arg Lys
 1               5                  10                  15      
Glu Lys Ser Arg Asp Ala Ala Arg Cys Arg Arg Ser Lys Glu Thr Glu
            20                  25                  30          
Val Phe Tyr Glu Leu Ala His Glu Leu Pro Leu Pro His Ser Val Ser
        35                  40                  45              
Ser His Leu Asp Lys Ala Ser Ile Met Arg Leu Ala Ile Ser Phe Leu
    50                  55                  60                  
Arg Thr His Lys Leu Leu Ser Ser Val Cys Ser Glu Asn Glu Ser Glu
65                  70                  75                  80  
Ala Glu Ala Asp Gln Gln Met Asp Asn Leu Tyr Leu Lys Ala Leu Glu
                85                  90                  95      
Gly Phe Ile Ala Val Val Thr Gln Asp Gly Asp Met Ile Phe Leu Ser
            100                 105                 110         
Glu Asn Ile Ser Lys Phe Met Gly Leu Thr Gln Val Glu Leu Thr Gly
        115                 120                 125             
His Ser Ile Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Ile Arg
    130                 135                 140                 
Glu Asn Leu Ser Leu Lys Asn Gly Ser Gly Phe Gly Lys Lys Ser Lys
145                 150                 155                 160 
Asp Met Ser Thr Glu Arg Asp Phe Phe Met Arg Met Lys Cys Thr Val
                165                 170                 175     
Thr Asn Arg Gly Arg Thr Val Asn Leu Lys Ser Ala Thr Trp Lys Val
            180                 185                 190         
Leu His Cys Thr Gly Gln Val Lys Val Tyr Asn Asn Cys Pro Pro His
        195                 200                 205             
Asn Ser Leu Cys Gly Tyr Lys Glu Pro Leu Leu Ser Cys Leu Ile Ile
    210                 215                 220                 
Met Cys Glu Pro Ile Gln His Pro Ser His Met Asp Ile Pro Leu Asp
225                 230                 235                 240 
Ser Lys Thr Phe Leu Ser Arg His Ser Met Asp Met Lys Phe Thr Tyr
                245                 250                 255     
Cys Asp Asp Arg Ile Thr Glu Leu Ile Gly Tyr His Pro Glu Glu Leu
            260                 265                 270         
Leu Gly Arg Ser Ala Tyr Glu Phe Tyr His Ala Leu Asp Ser Glu Asn
        275                 280                 285             
Met Thr Lys Ser His Gln Asn Leu Cys Thr Lys Gly Gln Val Val Ser
    290                 295                 300                 
Gly Gln Tyr Arg Met Leu Ala Lys His Gly Gly Tyr Val Trp Leu Glu
305                 310                 315                 320 
Thr Gln Gly Thr Val Ile Tyr Asn Pro Arg Asn Leu Gln Pro Gln Cys
                325                 330                 335     
Ile Met Cys Val Asn Tyr Val Leu Ser Glu Ile Glu Lys Asn Asp Val
            340                 345                 350         
Val Phe Ser Met Asp Gln Thr Glu Ser Leu Phe Lys Pro His Leu Met
        355                 360                 365             
Ala Met Asn Ser Ile Phe Asp Ser Ser Gly Lys Gly Ala Val Ser Glu
    370                 375                 380                 
Lys Ser Asn Phe Leu Phe Thr Lys Leu Lys Glu Glu Pro Glu Glu Leu
385                 390                 395                 400 
Ala Gln Leu Ala Pro Thr Pro Gly Asp Ala Ile Ile Ser Leu Asp Phe
                405                 410                 415     
Gly Asn Gln Asn Phe Glu Glu Ser Ser Ala Tyr Gly Lys Ala Ile Leu
            420                 425                 430         
Pro Pro Ser Gln Pro Trp Ala Thr Glu Leu Arg Ser His Ser Thr Gln
        435                 440                 445             
Ser Glu Ala Gly Ser Leu Pro Ala Phe Thr Val Pro Gln Ala Ala Ala
    450                 455                 460                 
Pro Gly Ser Thr Thr Pro Ser Ala Thr Ser Ser Ser Ser Ser Cys Ser
465                 470                 475                 480 
Thr Pro Asn Ser Pro Glu Asp Tyr Tyr Thr Ser Leu Asp Asn Asp Leu
                485                 490                 495     
Lys Ile Glu Val Ile Glu Lys Leu Phe Ala Met Asp Thr Glu Ala Lys
            500                 505                 510         
Asp Gln Cys Ser Thr Gln Thr Asp Phe Asn Glu Leu Asp Leu Glu Thr
        515                 520                 525             
Leu Ala Pro Tyr Ile Pro Met Asp Gly Glu Asp Phe Gln Leu Ser Pro
    530                 535                 540                 
Ile Cys Pro Glu Glu Arg Leu Leu Ala Glu Asn Pro Gln Ser Thr Pro
545                 550                 555                 560 
Gln His Cys Phe Ser Ala Met Thr Asn Ile Phe Gln Pro Leu Ala Pro
                565                 570                 575     
Val Ala Pro His Ser Pro Phe Leu Leu Asp Lys Phe Gln Gln Gln Leu
            580                 585                 590         
Glu Ser Lys Lys Thr Glu Pro Glu His Arg Pro Met Ser Ser Ile Phe
        595                 600                 605             
Phe Asp Ala Gly Ser Lys Ala Ser Leu Pro Pro Cys Cys Gly Gln Ala
    610                 615                 620                 
Ser Thr Pro Leu Ser Ser Met Gly Gly Arg Ser Asn Thr Gln Trp Pro
625                 630                 635                 640 
Pro Asp Pro Pro Leu His Phe Gly Pro Thr Lys Trp Ala Val Gly Asp
                645                 650                 655     
Gln Arg Thr Glu Phe Leu Gly Ala Ala Pro Leu Gly Pro Pro Val Ser
            660                 665                 670         
Pro Pro His Val Ser Thr Phe Lys Thr Arg Ser Ala Lys Gly Phe Gly
        675                 680                 685             
Ala Arg Gly Pro Asp Val Leu Ser Pro Ala Met Val Ala Leu Ser Asn
    690                 695                 700                 
Lys Leu Lys Leu Lys Arg Gln Leu Glu Tyr Glu Glu Gln Ala Phe Gln
705                 710                 715                 720 
Asp Leu Ser Gly Gly Asp Pro Pro Gly Gly Ser Thr Ser His Leu Met
                725                 730                 735     
Trp Lys Arg Met Lys Asn Leu Arg Gly Gly Ser Cys Pro Leu Met Pro
            740                 745                 750         
Asp Lys Pro Leu Ser Ala Asn Val Pro Asn Asp Lys Phe Thr Gln Asn
        755                 760                 765             
Pro Met Arg Gly Leu Gly His Pro Leu Arg His Leu Pro Leu Pro Gln
    770                 775                 780                 
Pro Pro Ser Ala Ile Ser Pro Gly Glu Asn Ser Lys Ser Arg Phe Pro
785                 790                 795                 800 
Pro Gln Cys Tyr Ala Thr Gln Tyr Gln Asp Tyr Ser Leu Ser Ser Ala
                805                 810                 815     
His Lys Val Ser Gly Met Ala Ser Arg Leu Leu Gly Pro Ser Phe Glu
            820                 825                 830         
Ser Tyr Leu Leu Pro Glu Leu Thr Arg Tyr Asp Cys Glu Val Asn Val
        835                 840                 845             
Pro Val Leu Gly Ser Ser Thr Leu Leu Gln Gly Gly Asp Leu Leu Arg
    850                 855                 860                 
Ala Leu Asp Gln Ala Thr
865                 870 


<210> 15
<211> 5827
<212> DNA
<213> Homo sapiens

<400> 15
ccgagagcgt gccccggacc gccagctcag aacaggggca gccgtgtagc cgaacggaag 60
ctgggagcag ccgggactgg tggcccgcgc ccgagctccg caggcgggaa gcaccctgga 120
tttaggaagt cccgggagca gcgcggcggc acctccctca cccaaggggc cgcggcgacg 180
gtcacggggc gcggcgccac cgtgagcgac ccaggccagg attctaaata gacggcccag 240
gctcctcctc cgcccgggcc gcctcacctg cgggcattgc cgcgccgcct ccgccggtgt 300
agacggcacc tgcgccgcct tgctcgcggg tctccgcccc tcgcccaccc tcactgcgcc 360
aggcccaggc agctcacctg tactggcgcg ggctgcggaa gcctgcgtga gccgaggcgt 420
tgaggcgcgg cgcccacgcc actgtcccga gaggacgcag gtggagcggg cgcggcttcg 480
cggaacccgg cgccggccgc cgcagtggtc ccagcctaca ccgggttccg gggacccggc 540
cgccagtgcc cggggagtag ccgccgccgt cggctgggca ccatgaacag cagcagcgcc 600
aacatcacct acgccagtcg caagcggcgg aagccggtgc agaaaacagt aaagccaatc 660
ccagctgaag gaatcaagtc aaatccttcc aagcggcata gagaccgact taatacagag 720
ttggaccgtt tggctagcct gctgcctttc ccacaagatg ttattaataa gttggacaaa 780
ctttcagttc ttaggctcag cgtcagttac ctgagagcca agagcttctt tgatgttgca 840
ttaaaatcct cccctactga aagaaacgga ggccaggata actgtagagc agcaaatttc 900
agagaaggcc tgaacttaca agaaggagaa ttcttattac aggctctgaa tggctttgta 960
ttagttgtca ctacagatgc tttggtcttt tatgcttctt ctactataca agattatcta 1020
gggtttcagc agtctgatgt catacatcag agtgtatatg aacttatcca taccgaagac 1080
cgagctgaat ttcagcgtca gctacactgg gcattaaatc cttctcagtg tacagagtct 1140
ggacaaggaa ttgaagaagc cactggtctc ccccagacag tagtctgtta taacccagac 1200
cagattcctc cagaaaactc tcctttaatg gagaggtgct tcatatgtcg tctaaggtgt 1260
ctgctggata attcatctgg ttttctggca atgaatttcc aagggaagtt aaagtatctt 1320
catggacaga aaaagaaagg gaaagatgga tcaatacttc cacctcagtt ggctttgttt 1380
gcgatagcta ctccacttca gccaccatcc atacttgaaa tccggaccaa aaattttatc 1440
tttagaacca aacacaaact agacttcaca cctattggtt gtgatgccaa aggaagaatt 1500
gttttaggat atactgaagc agagctgtgc acgagaggct caggttatca gtttattcat 1560
gcagctgata tgctttattg tgccgagtcc catatccgaa tgattaagac tggagaaagt 1620
ggcatgatag ttttccggct tcttacaaaa aacaaccgat ggacttgggt ccagtctaat 1680
gcacgcctgc tttataaaaa tggaagacca gattatatca ttgtaactca gagaccacta 1740
acagatgagg aaggaacaga gcatttacga aaacgaaata cgaagttgcc ttttatgttt 1800
accactggag aagctgtgtt gtatgaggca accaaccctt ttcctgccat aatggatccc 1860
ttaccactaa ggactaaaaa tggcactagt ggaaaagact ctgctaccac atccactcta 1920
agcaaggact ctctcaatcc tagttccctc ctggctgcca tgatgcaaca agatgagtct 1980
atttatctct atcctgcttc aagtacttca agtactgcac cttttgaaaa caactttttc 2040
aacgaatcta tgaatgaatg cagaaattgg caagataata ctgcaccgat gggaaatgat 2100
actatcctga aacatgagca aattgaccag cctcaggatg tgaactcatt tgctggaggt 2160
cacccagggc tctttcaaga tagtaaaaac agtgacttgt acagcataat gaaaaaccta 2220
ggcattgatt ttgaagacat cagacacatg cagaatgaaa aatttttcag aaatgatttt 2280
tctggtgagg ttgacttcag agacattgac ttaacggatg aaatcctgac gtatgtccaa 2340
gattctttaa gtaagtctcc cttcatacct tcagattatc aacagcaaca gtccttggct 2400
ctgaactcaa gctgtatggt acaggaacac ctacatctag aacagcaaca gcaacatcac 2460
caaaagcaag tagtagtgga gccacagcaa cagctgtgtc agaagatgaa gcacatgcaa 2520
gttaatggca tgtttgaaaa ttggaactct aaccaattcg tgcctttcaa ttgtccacag 2580
caagacccac aacaatataa tgtctttaca gacttacatg ggatcagtca agagttcccc 2640
tacaaatctg aaatggattc tatgccttat acacagaact ttatttcctg taatcagcct 2700
gtattaccac aacattccaa atgtacagag ctggactacc ctatggggag ttttgaacca 2760
tccccatacc ccactacttc tagtttagaa gattttgtca cttgtttaca acttcctgaa 2820
aaccaaaagc atggattaaa tccacagtca gccataataa ctcctcagac atgttatgct 2880
ggggccgtgt cgatgtatca gtgccagcca gaacctcagc acacccacgt gggtcagatg 2940
cagtacaatc cagtactgcc aggccaacag gcatttttaa acaagtttca gaatggagtt 3000
ttaaatgaaa catatccagc tgaattaaat aacataaata acactcagac taccacacat 3060
cttcagccac ttcatcatcc gtcagaagcc agaccttttc ctgatttgac atccagtgga 3120
ttcctgtaat tccaagccca attttgaccc tggtttttgg attaaattag tttgtgaagg 3180
attatggaaa aataaaactg tcactgttgg acgtcagcaa gttcacatgg aggcattgat 3240
gcatgctatt cacaattatt ccaaaccaaa ttttaatttt tgcttttaga aaagggagtt 3300
taaaaatggt atcaaaatta catatactac agtcaagata gaaagggtgc tgccacggag 3360
tggtgaggta ccgtctacat ttcacattat tctgggcacc acaaaatata caaaacttta 3420
tcagggaaac taagattctt ttaaattaga aaatattctc tatttgaatt atttctgtca 3480
cagtaaaaat aaaatacttt gagttttgag ctactggatt cttattagtt ccccaaatac 3540
aaagttagag aactaaacta gtttttccta tcatgttaac ctctgctttt atctcagatg 3600
ttaaaataaa tggtttggtg ctttttataa aaagataatc tcagtgcttt cctccttcac 3660
tgtttcatct aagtgcctca catttttttc tacctataac actctaggat gtatatttta 3720
tataaagtat tctttttctt ttttaaatta atatctttct gcacacaaat attatttgtg 3780
tttcctaaat ccaaccattt tcattaattc aggcatattt taactccact gcttacctac 3840
tttcttcagg taaagggcaa ataatgatcg aaaaaataat tatttattac ataatttagt 3900
tgtttctaga ctataaatgt tgctatgtgc cttatgttga aaaaatttaa aagtaaaatg 3960
tctttccaaa ttatttctta attattataa aaatattaag acaatagcac ttaaattcct 4020
caacagtgtt ttcagaagaa ataaatatac cactctttac ctttattgat atctccatga 4080
tgatagttga atgttgcaat gtgaaaaatc tgctgttaac tgcaaccttg tttattaaat 4140
tgcaagaagc tttatttcta gctttttaat taagcaaagc acccatttca atgtgtataa 4200
attgtcttta aaaactgttt tagacctata atccttgata atatattgtg ttgactttat 4260
aaatttcgct tcttagaaca gtggaaacta tgtgtttttc tcatatttga ggagtgttaa 4320
gattgcagat agcaaggttt ggtgcaaagt attgtaatga gtgaattgaa tggtgcattg 4380
tatagatata atgaacaaaa ttatttgtaa gatatttgca gtttttcatt ttaaaaagtc 4440
cataccttat atatgcactt aatttgttgg ggctttacat actttatcaa tgtgtctttc 4500
taagaaatca agtaatgaat ccaactgctt aaagttggta ttaataaaaa gacaaccaca 4560
tagttcgttt accttcaaac tttaggtttt tttaatgata tactgatctt cattaccaat 4620
aggcaaatta atcaccctac caactttact gtcctaacat ggtttaaaag aaaaaatgac 4680
accatctttt attctttttt tttttttttt ttgagagaga gtcttactct gccgcccaaa 4740
ctggagtgca gtggcacaat cttggctcac tgcaacctct acctcctggg ttcaagtgat 4800
tctcttgcct cagcctcccg agttgctggg attacaggca tggtggcgtg agcctgtagt 4860
cctagctact caggaggctg aggcaggaga atagcctgaa cctgggaatc ggaggttgca 4920
gagccaagat cgccccactg cactccagcc tggcaataga ccgagactcc gtctccaaaa 4980
aaaaaaaaaa tacaattttt atttctttta ctttttttag taagttaatg tatataaaaa 5040
tggcttcgga caaaatatct ctgagttctg tgtattttca gtcaaaactt taaacctgta 5100
gaatcaattt aagtgttgga aaaaatttgt ctgaaacatt tcataatttg tttccagcat 5160
gaggtatcta aggatttaga ccagaggtct agattaatac tctattttta catttaaacc 5220
ttttattata agtcttacat aaaccatttt tgttactctc ttccacatgt tactggataa 5280
attgtttagt ggaaaatagg ctttttaatc atgaatatga tgacaatcag ttatacagtt 5340
ataaaattaa aagtttgaaa agcaatattg tatattttta tctatataaa ataactaaaa 5400
tgtatctaag aataataaaa tcacgttaaa ccaaatacac gtttgtctgt attgttaagt 5460
gccaaacaaa ggatacttag tgcactgcta cattgtggga tttatttcta gatgatgtgc 5520
acatctaagg atatggatgt gtctaattta gtcttttcct gtaccaggtt tttcttacaa 5580
tacctgaaga cttaccagta ttctagtgta ttatgaagct ttcaacatta ctatgcacaa 5640
actagtgttt ttcgatgtta ctaaatttta ggtaaatgct ttcatggctt ttttcttcaa 5700
aatgttactg cttacatata tcatgcatag atttttgctt aaagtatgat ttataatatc 5760
ctcattatca aagttgtata caataatata taataaaata acaaatatga ataaaaaaaa 5820
aaaaaaa                                                           5827



<210> 16
<211> 848
<212> PRT
<213> Homo sapiens

<400> 16
Met Asn Ser Ser Ser Ala Asn Ile Thr Tyr Ala Ser Arg Lys Arg Arg
 1               5                  10                  15      
Lys Pro Val Gln Lys Thr Val Lys Pro Ile Pro Ala Glu Gly Ile Lys
            20                  25                  30          
Ser Asn Pro Ser Lys Arg His Arg Asp Arg Leu Asn Thr Glu Leu Asp
        35                  40                  45              
Arg Leu Ala Ser Leu Leu Pro Phe Pro Gln Asp Val Ile Asn Lys Leu
    50                  55                  60                  
Asp Lys Leu Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Ala Lys
65                  70                  75                  80  
Ser Phe Phe Asp Val Ala Leu Lys Ser Ser Pro Thr Glu Arg Asn Gly
                85                  90                  95      
Gly Gln Asp Asn Cys Arg Ala Ala Asn Phe Arg Glu Gly Leu Asn Leu
            100                 105                 110         
Gln Glu Gly Glu Phe Leu Leu Gln Ala Leu Asn Gly Phe Val Leu Val
        115                 120                 125             
Val Thr Thr Asp Ala Leu Val Phe Tyr Ala Ser Ser Thr Ile Gln Asp
    130                 135                 140                 
Tyr Leu Gly Phe Gln Gln Ser Asp Val Ile His Gln Ser Val Tyr Glu
145                 150                 155                 160 
Leu Ile His Thr Glu Asp Arg Ala Glu Phe Gln Arg Gln Leu His Trp
                165                 170                 175     
Ala Leu Asn Pro Ser Gln Cys Thr Glu Ser Gly Gln Gly Ile Glu Glu
            180                 185                 190         
Ala Thr Gly Leu Pro Gln Thr Val Val Cys Tyr Asn Pro Asp Gln Ile
        195                 200                 205             
Pro Pro Glu Asn Ser Pro Leu Met Glu Arg Cys Phe Ile Cys Arg Leu
    210                 215                 220                 
Arg Cys Leu Leu Asp Asn Ser Ser Gly Phe Leu Ala Met Asn Phe Gln
225                 230                 235                 240 
Gly Lys Leu Lys Tyr Leu His Gly Gln Lys Lys Lys Gly Lys Asp Gly
                245                 250                 255     
Ser Ile Leu Pro Pro Gln Leu Ala Leu Phe Ala Ile Ala Thr Pro Leu
            260                 265                 270         
Gln Pro Pro Ser Ile Leu Glu Ile Arg Thr Lys Asn Phe Ile Phe Arg
        275                 280                 285             
Thr Lys His Lys Leu Asp Phe Thr Pro Ile Gly Cys Asp Ala Lys Gly
    290                 295                 300                 
Arg Ile Val Leu Gly Tyr Thr Glu Ala Glu Leu Cys Thr Arg Gly Ser
305                 310                 315                 320 
Gly Tyr Gln Phe Ile His Ala Ala Asp Met Leu Tyr Cys Ala Glu Ser
                325                 330                 335     
His Ile Arg Met Ile Lys Thr Gly Glu Ser Gly Met Ile Val Phe Arg
            340                 345                 350         
Leu Leu Thr Lys Asn Asn Arg Trp Thr Trp Val Gln Ser Asn Ala Arg
        355                 360                 365             
Leu Leu Tyr Lys Asn Gly Arg Pro Asp Tyr Ile Ile Val Thr Gln Arg
    370                 375                 380                 
Pro Leu Thr Asp Glu Glu Gly Thr Glu His Leu Arg Lys Arg Asn Thr
385                 390                 395                 400 
Lys Leu Pro Phe Met Phe Thr Thr Gly Glu Ala Val Leu Tyr Glu Ala
                405                 410                 415     
Thr Asn Pro Phe Pro Ala Ile Met Asp Pro Leu Pro Leu Arg Thr Lys
            420                 425                 430         
Asn Gly Thr Ser Gly Lys Asp Ser Ala Thr Thr Ser Thr Leu Ser Lys
        435                 440                 445             
Asp Ser Leu Asn Pro Ser Ser Leu Leu Ala Ala Met Met Gln Gln Asp
    450                 455                 460                 
Glu Ser Ile Tyr Leu Tyr Pro Ala Ser Ser Thr Ser Ser Thr Ala Pro
465                 470                 475                 480 
Phe Glu Asn Asn Phe Phe Asn Glu Ser Met Asn Glu Cys Arg Asn Trp
                485                 490                 495     
Gln Asp Asn Thr Ala Pro Met Gly Asn Asp Thr Ile Leu Lys His Glu
            500                 505                 510         
Gln Ile Asp Gln Pro Gln Asp Val Asn Ser Phe Ala Gly Gly His Pro
        515                 520                 525             
Gly Leu Phe Gln Asp Ser Lys Asn Ser Asp Leu Tyr Ser Ile Met Lys
    530                 535                 540                 
Asn Leu Gly Ile Asp Phe Glu Asp Ile Arg His Met Gln Asn Glu Lys
545                 550                 555                 560 
Phe Phe Arg Asn Asp Phe Ser Gly Glu Val Asp Phe Arg Asp Ile Asp
                565                 570                 575     
Leu Thr Asp Glu Ile Leu Thr Tyr Val Gln Asp Ser Leu Ser Lys Ser
            580                 585                 590         
Pro Phe Ile Pro Ser Asp Tyr Gln Gln Gln Gln Ser Leu Ala Leu Asn
        595                 600                 605             
Ser Ser Cys Met Val Gln Glu His Leu His Leu Glu Gln Gln Gln Gln
    610                 615                 620                 
His His Gln Lys Gln Val Val Val Glu Pro Gln Gln Gln Leu Cys Gln
625                 630                 635                 640 
Lys Met Lys His Met Gln Val Asn Gly Met Phe Glu Asn Trp Asn Ser
                645                 650                 655     
Asn Gln Phe Val Pro Phe Asn Cys Pro Gln Gln Asp Pro Gln Gln Tyr
            660                 665                 670         
Asn Val Phe Thr Asp Leu His Gly Ile Ser Gln Glu Phe Pro Tyr Lys
        675                 680                 685             
Ser Glu Met Asp Ser Met Pro Tyr Thr Gln Asn Phe Ile Ser Cys Asn
    690                 695                 700                 
Gln Pro Val Leu Pro Gln His Ser Lys Cys Thr Glu Leu Asp Tyr Pro
705                 710                 715                 720 
Met Gly Ser Phe Glu Pro Ser Pro Tyr Pro Thr Thr Ser Ser Leu Glu
                725                 730                 735     
Asp Phe Val Thr Cys Leu Gln Leu Pro Glu Asn Gln Lys His Gly Leu
            740                 745                 750         
Asn Pro Gln Ser Ala Ile Ile Thr Pro Gln Thr Cys Tyr Ala Gly Ala
        755                 760                 765             
Val Ser Met Tyr Gln Cys Gln Pro Glu Pro Gln His Thr His Val Gly
    770                 775                 780                 
Gln Met Gln Tyr Asn Pro Val Leu Pro Gly Gln Gln Ala Phe Leu Asn
785                 790                 795                 800 
Lys Phe Gln Asn Gly Val Leu Asn Glu Thr Tyr Pro Ala Glu Leu Asn
                805                 810                 815     
Asn Ile Asn Asn Thr Gln Thr Thr Thr His Leu Gln Pro Leu His His
            820                 825                 830         
Pro Ser Glu Ala Arg Pro Phe Pro Asp Leu Thr Ser Ser Gly Phe Leu
        835                 840                 845             







