                         SEQUENCE LISTING

<110>  Eli Lilly and Company
       Bales, Kelly R
       Bumol, Thomas F
       Chow, Chi-Kin
       Demattos, Ronald B
       Hansen, Ryan
       Kuchibholta, Uma
       Lu, Jirong
       McDonnell, Peter
 
<120>  PEGYLATED A Beta  FAB

<130>  X17087

<150>  US 60/885439
<151>  2007-01-18

<160>  14    

<170>  PatentIn version 3.4

<210>  1
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  1

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Ser Ser Ser Gln Ser Leu Ile Tyr Ser 
            20                  25                  30          


Asp Gly Asn Ala Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Thr Gln Ser 
                85                  90                  95      


Thr His Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  2
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gln Ile Asn Ile Arg Gly Cys Asn Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  3
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gln Ile Asn Ile Arg Gly Asn Asn Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  4
<211>  16
<212>  PRT
<213>  homo sapiens

<400>  4

His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys 
1               5                   10                  15      


<210>  5
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  5

His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys 
1               5                   10                  15  


<210>  6
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  6

Ser Ser Ser Gln Ser Leu Ile Tyr Ser Asp Gly Asn Ala Tyr Leu His 
1               5                   10                  15      


<210>  7
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  7

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  8

Thr Gln Ser Thr His Ser Pro Trp Thr 
1               5                   


<210>  9
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  9

Gly Tyr Thr Phe Ser Arg Tyr Ser Met Ser 
1               5                   10  


<210>  10
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  10

Gln Ile Asn Ile Arg Gly Cys Asn Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


<210>  11
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  11

Gln Ile Asn Ile Arg Gly Asn Asn Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  12

Gly Asp Phe 
1           


<210>  13
<211>  657
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  13
gacatcgtta tgactcagac tccattgtcc ttgtctgtta ctccaggtca accagcttct     60

atttcctgtt cctcctccca atctttgatc tactccgacg gtaacgctta cttgcactgg    120

tacttgcaaa agcctggtca atccccacaa ttgttgatct acaaggtttc caacagattc    180

tctggtgttc ctgacagatt ttctggttcc ggttccggta ctgacttcac tttgaagatc    240

tccagagttg aagctgagga tgttggtgtt tactactgta ctcagtccac tcattcccca    300

tggacttttg gtggtggtac taaggttgag atcaagagaa ctgttgctgc tccatccgtt    360

ttcattttcc caccatccga cgaacaattg aagtctggta ctgcttccgt tgtttgtttg    420

ttgaacaact tctacccaag agaggctaag gttcagtgga aggttgacaa cgctttgcaa    480

tccggtaact cccaagaatc cgttactgag caagactcta aggactccac ttactccttg    540

tcctccactt tgactttgtc caaggctgat tacgagaagc acaaggttta cgcttgtgag    600

gttacacatc agggtttgtc ctccccagtt actaagtcct tcaacagagg agagtcc       657


<210>  14
<211>  657
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  14
gaggttcagt tggttgaatc tggtggtgga ttggttaagc ctggtggttc tttgagattg     60

tcctgtgctg cttccggtta cactttctcc agatactcca tgtcctgggt tagacaagct    120

ccaggaaagg gattggagtg ggttggtcaa atcaacatca gaggttgtaa cacttactac    180

ccagacactg ttaagggaag attcactatc tccagagatg actccaagaa cactttgtac    240

ttgcagatga actccttgaa aactgaggac actgctgttt actactgtac tactggtgac    300

ttttggggac agggaacttt ggttactgtt tcctccgctt ctactaaggg accatccgtt    360

tttccattgg ctccatcctc taagtctact tccggtggta ctgctgcttt gggatgtttg    420

gttaaggact acttcccaga gccagttact gtttcttgga actccggtgc tttgacttct    480

ggtgttcaca ctttcccagc tgttttgcaa tcttccggtt tgtactcctt gtcctccgtt    540

gttactgttc catcctcttc cttgggtact cagacttaca tctgtaacgt taaccacaag    600

ccatccaaca ctaaggttga caagaaggtt gaaccaaagt cctctgacaa gactcac       657


