                         SEQUENCE LISTING

<110>  Immunotope, Inc.
 
<120>  CYTOTOXIC T-LYMPHOCYTE-INDUCING IMMUNOGENS

<130>  P33900 PCT

<140>  PCT/US2007/077250
<141>  2007-08-30

<150>  11/846,872
<151>  2007-08-29

<150>  60/841,121
<151>  2006-08-30

<160>  233   

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  1

Glu Met Thr Thr Leu Glu Lys Val Ile 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  2

Ser Leu Pro Glu Phe Gln Gln Phe Leu 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  3

Thr Leu Leu Thr Lys Pro Val Glu Ile 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  4

Ala Ile Leu Gly Pro Thr Phe Thr Leu 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  5

Phe Leu Asp Lys Glu Leu Thr Gly Leu 
1               5                   


<210>  6
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  6

Lys Leu Leu Glu Pro Val Leu Leu 
1               5               


<210>  7
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  7

Arg Leu Phe Glu Gly Asn Ala Leu Leu 
1               5                   


<210>  8
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  8

Tyr Asp Ala Leu Asp Val Ala Asn Lys Ile Gly Ile Ile 
1               5                   10              


<210>  9
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  9

Met Asp Leu Asn Lys Thr Glu Glu Val 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  10

Lys Leu Leu Pro Gln Leu Thr Tyr Leu 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  11

Phe Val Leu Asp Lys Val Pro Phe Leu 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  12

Asp Glu Glu Phe Glu Ile Glu Leu Glu 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  13

Leu Ser Asp Phe Leu Lys Ala Asn Val 
1               5                   


<210>  14
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  14

Gly Gly Lys Met Leu Leu Ile Ala Ile Leu 
1               5                   10  


<210>  15
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  15

Asn Glu Asp Ala Leu Ile Glu Ile Leu 
1               5                   


<210>  16
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  16

Pro Ala Pro Ala Thr Thr Phe Ala His Leu Asp 
1               5                   10      


<210>  17
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  17

Tyr Leu Leu Glu Met Lys Leu Lys Asn 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  18

Asn Leu Glu Gln Gln Glu Thr Glu Pro 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  19

Lys Ile Ile Asp Ile Phe Thr Thr Leu 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  20

Tyr Gly Leu Pro Val Val Val Lys Leu 
1               5                   


<210>  21
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  21

Leu Asn Leu Met Ala Leu Gly Gly Phe Leu 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  22

Asn Leu Ala Val Ile Phe Asp Leu Leu Leu 
1               5                   10  


<210>  23
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  23

Pro Ser Ile Leu Glu Leu Glu Glu Leu 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  24

Ser Leu Ile Thr Leu Ile Glu Lys Val 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  25

Phe Glu Asn Gln Glu Val Gln Ala Ile 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  26

Gly Lys Leu Leu Asn Glu Val Lys Ile 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  27

Trp Leu Ala Glu Lys Leu Pro Thr Leu 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  28

Asn Ile Ile Pro Tyr Ile Thr Asn Val 
1               5                   


<210>  29
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  29

Lys Leu Leu Pro Gly Asp Ile His Gln Ile 
1               5                   10  


<210>  30
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  30

Phe Ile Glu Gly Glu Leu Asp Asp Arg 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  31

Asn Leu Asn Asp Lys Gln Ile Val Lys 
1               5                   


<210>  32
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  32

Tyr Leu Lys Ile Leu Asn Glu Gln 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  33

Ile Glu Lys Asp Ser Pro Phe Ile 
1               5               


<210>  34
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  34

Arg Val Ile Asp Tyr Ile Leu Asp Leu 
1               5                   


<210>  35
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  35

Arg Leu Asp Glu Leu Gly Gly Val Tyr Leu 
1               5                   10  


<210>  36
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  36

Glu Asp Leu Asn Gln Gln Leu Leu Glu 
1               5                   


<210>  37
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  37

Val Tyr Ile Val Gln Asp Gly Pro Pro Gln 
1               5                   10  


<210>  38
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  38

Phe Leu Asp Lys Gln Gly Phe Tyr Val 
1               5                   


<210>  39
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  39

Glu Ala Leu Asn Lys Lys Ala Ile Gln Ile 
1               5                   10  


<210>  40
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  40

Tyr Leu Asp Leu Ser Glu Asn Arg Leu 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  41

Leu Gln Glu Leu Pro Tyr Asn Glu Leu 
1               5                   


<210>  42
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  42

Ala Leu Leu Arg Arg Pro Thr Val 
1               5               


<210>  43
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  43

Thr Leu Leu Arg Leu Leu Tyr Glu Ala 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  44

Ile Leu Pro Val Pro Ala Phe Asn Val 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  45

Leu Glu Asn Ser Glu Ala Leu Glu Leu 
1               5                   


<210>  46
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  46

Ala Leu Pro Glu Thr Thr Phe Pro Ala Leu 
1               5                   10  


<210>  47
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  47

Phe Val Glu Val Lys Asp Pro Glu Asp 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  48

Glu Ala Gln Glu Glu Ile Ala Phe Leu 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  49

Gln Leu Val Val Glu Leu Lys Asp Ile 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  50

Val Leu Lys Glu Ile Val Glu Arg Val 
1               5                   


<210>  51
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  51

Ser Leu Ser Val Gln Ser Pro Ala Ala Leu 
1               5                   10  


<210>  52
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  52

Tyr Ile Asp Leu Leu Lys Lys Met Leu 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  53

Pro Glu Asp Glu Glu Pro Glu Asn Leu 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  54

Ser Leu Pro Glu Val Leu Pro Ile Leu 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  55

Tyr Val Ile Thr Asp Leu Thr Gln Leu 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  56

Phe Ile Leu Leu Ile Leu Ser Leu Ile 
1               5                   


<210>  57
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  57

Ile Arg Pro Phe Asp Gln Leu Phe Ala Leu 
1               5                   10  


<210>  58
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  58

Gly Gln Val Glu Arg Phe Glu Thr Val 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  59

Lys Ile Leu Asp Tyr Glu Val Thr Leu 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  60

Leu Leu Leu Glu Asn Asn Ala Gln Val 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  61

Glu Asn Glu Glu Glu Glu Ile Glu Leu 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  62

Pro Phe Ser Met Glu Lys Leu Leu Tyr 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  63

Ala Leu Trp Asn Glu Glu Ala Leu Leu 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  64

Leu Glu Asn Glu Ala Asn Asn Ile Lys 
1               5                   


<210>  65
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  65

Met Lys Arg Leu Leu Leu Leu Phe 
1               5               


<210>  66
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  66

Phe Pro Ile Leu Thr Val Leu Gln Ala Val 
1               5                   10  


<210>  67
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  67

Gln Ile Leu Ser Leu Glu Glu Lys Ile 
1               5                   


<210>  68
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  68

Leu Gln Asn Phe Glu Met Gln Pro Lys Leu 
1               5                   10  


<210>  69
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  69

Arg Leu Gln Met Leu Leu Val Phe 
1               5               


<210>  70
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  70

Lys Leu Ile Leu Arg Leu His Lys Leu 
1               5                   


<210>  71
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  71

Glu Ile Ser Asp Glu Leu Met Glu Phe 
1               5                   


<210>  72
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  72

Tyr Asn Leu Lys Asp Arg Leu Thr 
1               5               


<210>  73
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  73

Ala Asn Ile Glu Gly Leu Glu Gly Lys Leu 
1               5                   10  


<210>  74
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  74

Lys Met Pro Lys Ile Lys Met Pro Lys 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  75

Ser Ile Leu Ser Leu Val Thr Lys Ile 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  76

Leu Leu Asp Gln Leu Asp Lys Asp Ile 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  77

Ser Asn Leu Leu Val Leu Leu Asn Asp 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  78

Tyr Ile Gly Glu Ile Phe Thr Gln Ile 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  79

Met Ile Leu Asn Ser Leu Ile Asn Lys 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  80

Met Gln Ser Asp Leu Ile Pro Glu Glu 
1               5                   


<210>  81
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  81

Phe Leu Leu Asp Pro Val Lys Gly Glu Arg Leu 
1               5                   10      


<210>  82
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  82

Val Ala Gly Ile Lys Val Asn Gln Val Lys 
1               5                   10  


<210>  83
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  83

Gln Leu Val Asp Ile Ile Glu Lys Val 
1               5                   


<210>  84
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  84

Lys Leu Pro Phe Thr Ile Pro Glu Leu 
1               5                   


<210>  85
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  85

Lys Glu His Leu Tyr Phe Glu Thr Val 
1               5                   


<210>  86
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  86

Ser Leu Leu Pro Pro Asp Ala Leu Val Gly Leu 
1               5                   10      


<210>  87
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  87

Lys Leu Phe Gly Met Ile Ile Thr Ile 
1               5                   


<210>  88
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  88

Leu Leu Val Glu Pro Val Ile Asn Ser Tyr 
1               5                   10  


<210>  89
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  89

Asn Glu Pro Gln Tyr Ile Ile Leu Glu 
1               5                   


<210>  90
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  90

Glu Ala Phe Leu Gln Glu Ala Gln Ile 
1               5                   


<210>  91
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  91

Leu Leu Glu Ile Glu Asp Leu Gln Val 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  92

Val Thr Asp Lys Val Leu Asn Ser Ile 
1               5                   


<210>  93
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  93

Leu Asp Leu Ile Met Lys Arg Met Glu 
1               5                   


<210>  94
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  94

Cys Glu Glu Ile Leu Asn Tyr Val Leu 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  95

Glu Glu Glu Ala Ile Leu Leu Glu Ile 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  96

Tyr Leu Ser Glu Gln Asp Ser Glu Leu 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  97

Asn Ile Ile Ser Lys Ile Thr Ala Glu 
1               5                   


<210>  98
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  98

Lys Ile Leu Leu Pro Leu Ile Asn Gln 
1               5                   


<210>  99
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  99

Asn Glu Leu Ala Leu Ser Leu Glu Glu Pro 
1               5                   10  


<210>  100
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  100

Glu Asp Gln Gly Leu Ile Leu Gln Asp 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  101

Gln Leu Ile Asp Lys Val Trp Gln Leu 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  102

Lys Ile Pro Val Ser Ala Phe Leu Leu 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  103

Phe Leu Asp Pro Glu Lys Lys Leu Phe 
1               5                   


<210>  104
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  104

Met Asp Lys Glu Val Asp Asp Ile Leu 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  105

Tyr Arg Ser Asp Leu Glu Ile Ile Phe 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  106

Ile Leu Leu Lys Asp Ile Leu Ser Val 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  107

Leu Leu Ile Glu Arg Gly Ala Ser Leu 
1               5                   


<210>  108
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  108

Thr Leu Gln Glu Phe Leu Lys Leu Ala 
1               5                   


<210>  109
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  109

Ser Leu Val Asp Ile Tyr Ser Gln Leu 
1               5                   


<210>  110
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  110

Tyr Leu Leu Asp Leu His Ser Tyr Leu 
1               5                   


<210>  111
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  111

Tyr Leu Ile Glu Leu Lys Lys Asn 
1               5               


<210>  112
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  112

Met Leu Pro Ser Ile Leu Asn Gln Leu 
1               5                   


<210>  113
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  113

Ala Phe Lys Asn Leu Val Gln Arg Asn 
1               5                   


<210>  114
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  114

Ile Ser Asn Asp Lys Phe Glu Tyr Leu 
1               5                   


<210>  115
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  115

Val Ile Leu His Leu Thr Val Leu Leu 
1               5                   


<210>  116
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  116

Asn Leu Phe Arg Ala Pro Ile Tyr Leu 
1               5                   


<210>  117
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  117

Asn Met Glu Glu Gln Pro Ile Asn Ile 
1               5                   


<210>  118
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  118

Ser Val Val Pro Tyr Leu Pro Arg Leu 
1               5                   


<210>  119
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  119

Ile Ile Val Asp Ile Phe His Gly Leu 
1               5                   


<210>  120
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  120

Asp Glu Glu Leu Ala Lys Val Glu Ile 
1               5                   


<210>  121
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  121

Lys Leu Phe Asn Glu Phe Ile Gln Leu 
1               5                   


<210>  122
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  122

Asp Leu Glu Val Lys Gln Glu Glu Val 
1               5                   


<210>  123
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  123

Met Gln Asp Val Leu Leu Ser Asn Glu 
1               5                   


<210>  124
<211>  999
<212>  PRT
<213>  homo sapiens

<400>  124

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
        595                 600                 605             


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
    610                 615                 620                 


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
625                 630                 635                 640 


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
                645                 650                 655     


Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala 
            660                 665                 670         


Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys 
        675                 680                 685             


Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val 
    690                 695                 700                 


Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val 
705                 710                 715                 720 


Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                725                 730                 735     


Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
            740                 745                 750         


Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
        755                 760                 765             


Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp 
    770                 775                 780                 


Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu 
785                 790                 795                 800 


Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys 
                805                 810                 815     


Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
            820                 825                 830         


Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
        835                 840                 845             


Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr 
    850                 855                 860                 


Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
865                 870                 875                 880 


Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                885                 890                 895     


Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
            900                 905                 910         


Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala Glu Pro 
        915                 920                 925             


Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile Pro Pro 
    930                 935                 940                 


Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu Lys Val 
945                 950                 955                 960 


Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu Gly Gly 
                965                 970                 975     


Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg 
            980                 985                 990         


Pro Leu Lys Asn Asp Glu Leu 
        995                 


<210>  125
<211>  1290
<212>  PRT
<213>  homo sapiens

<400>  125

Met Ala Gly Ala Ala Ser Pro Cys Ala Asn Gly Cys Gly Pro Gly Ala 
1               5                   10                  15      


Pro Ser Asp Ala Glu Val Leu His Leu Cys Arg Ser Leu Glu Val Gly 
            20                  25                  30          


Thr Val Met Thr Leu Phe Tyr Ser Lys Lys Ser Gln Arg Pro Glu Arg 
        35                  40                  45              


Lys Thr Phe Gln Val Lys Leu Glu Thr Arg Gln Ile Thr Trp Ser Arg 
    50                  55                  60                  


Gly Ala Asp Lys Ile Glu Gly Ala Ile Asp Ile Arg Glu Ile Lys Glu 
65                  70                  75                  80  


Ile Arg Pro Gly Lys Thr Ser Arg Asp Phe Asp Arg Tyr Gln Glu Asp 
                85                  90                  95      


Pro Ala Phe Arg Pro Asp Gln Ser His Cys Phe Val Ile Leu Tyr Gly 
            100                 105                 110         


Met Glu Phe Arg Leu Lys Thr Leu Ser Leu Gln Ala Thr Ser Glu Asp 
        115                 120                 125             


Glu Val Asn Met Trp Ile Lys Gly Leu Thr Trp Leu Met Glu Asp Thr 
    130                 135                 140                 


Leu Gln Ala Pro Thr Pro Leu Gln Ile Glu Arg Trp Leu Arg Lys Gln 
145                 150                 155                 160 


Phe Tyr Ser Val Asp Arg Asn Arg Glu Asp Arg Ile Ser Ala Lys Asp 
                165                 170                 175     


Leu Lys Asn Met Leu Ser Gln Val Asn Tyr Arg Val Pro Asn Met Arg 
            180                 185                 190         


Phe Leu Arg Glu Arg Leu Thr Asp Leu Glu Gln Arg Ser Gly Asp Ile 
        195                 200                 205             


Thr Tyr Gly Gln Phe Ala Gln Leu Tyr Arg Ser Leu Met Tyr Ser Ala 
    210                 215                 220                 


Gln Lys Thr Met Asp Leu Pro Phe Leu Glu Ala Ser Thr Leu Arg Ala 
225                 230                 235                 240 


Gly Glu Arg Pro Glu Leu Cys Arg Val Ser Leu Pro Glu Phe Gln Gln 
                245                 250                 255     


Phe Leu Leu Asp Tyr Gln Gly Glu Leu Trp Ala Val Asp Arg Leu Gln 
            260                 265                 270         


Val Gln Glu Phe Met Leu Ser Phe Leu Arg Asp Pro Leu Arg Glu Ile 
        275                 280                 285             


Glu Glu Pro Tyr Phe Phe Leu Asp Glu Phe Val Thr Phe Leu Phe Ser 
    290                 295                 300                 


Lys Glu Asn Ser Val Trp Asn Ser Gln Leu Asp Ala Val Cys Pro Asp 
305                 310                 315                 320 


Thr Met Asn Asn Pro Leu Ser His Tyr Trp Ile Ser Ser Ser His Asn 
                325                 330                 335     


Thr Tyr Leu Thr Gly Asp Gln Phe Ser Ser Glu Ser Ser Leu Glu Ala 
            340                 345                 350         


Tyr Ala Arg Cys Leu Arg Met Gly Cys Arg Cys Ile Glu Leu Asp Cys 
        355                 360                 365             


Trp Asp Gly Pro Asp Gly Met Pro Val Ile Tyr His Gly His Thr Leu 
    370                 375                 380                 


Thr Thr Lys Ile Lys Phe Ser Asp Val Leu His Thr Ile Lys Glu His 
385                 390                 395                 400 


Ala Phe Val Ala Ser Glu Tyr Pro Val Ile Leu Ser Ile Glu Asp His 
                405                 410                 415     


Cys Ser Ile Ala Gln Gln Arg Asn Met Ala Gln Tyr Phe Lys Lys Val 
            420                 425                 430         


Leu Gly Asp Thr Leu Leu Thr Lys Pro Val Glu Ile Ser Ala Asp Gly 
        435                 440                 445             


Leu Pro Ser Pro Asn Gln Leu Lys Arg Lys Ile Leu Ile Lys His Lys 
    450                 455                 460                 


Lys Leu Ala Glu Gly Ser Ala Tyr Glu Glu Val Pro Thr Ser Met Met 
465                 470                 475                 480 


Tyr Ser Glu Asn Asp Ile Ser Asn Ser Ile Lys Asn Gly Ile Leu Tyr 
                485                 490                 495     


Leu Glu Asp Pro Val Asn His Glu Trp Tyr Pro His Tyr Phe Val Leu 
            500                 505                 510         


Thr Ser Ser Lys Ile Tyr Tyr Ser Glu Glu Thr Ser Ser Asp Gln Gly 
        515                 520                 525             


Asn Glu Asp Glu Glu Glu Pro Lys Glu Val Ser Ser Ser Thr Glu Leu 
    530                 535                 540                 


His Ser Asn Glu Lys Trp Phe His Gly Lys Leu Gly Ala Gly Arg Asp 
545                 550                 555                 560 


Gly Arg His Ile Ala Glu Arg Leu Leu Thr Glu Tyr Cys Ile Glu Thr 
                565                 570                 575     


Gly Ala Pro Asp Gly Ser Phe Leu Val Arg Glu Ser Glu Thr Phe Val 
            580                 585                 590         


Gly Asp Tyr Thr Leu Ser Phe Trp Arg Asn Gly Lys Val Gln His Cys 
        595                 600                 605             


Arg Ile His Ser Arg Gln Asp Ala Gly Thr Pro Lys Phe Phe Leu Thr 
    610                 615                 620                 


Asp Asn Leu Val Phe Asp Ser Leu Tyr Asp Leu Ile Thr His Tyr Gln 
625                 630                 635                 640 


Gln Val Pro Leu Arg Cys Asn Glu Phe Glu Met Arg Leu Ser Glu Pro 
                645                 650                 655     


Val Pro Gln Thr Asn Ala His Glu Ser Lys Glu Trp Tyr His Ala Ser 
            660                 665                 670         


Leu Thr Arg Ala Gln Ala Glu His Met Leu Met Arg Val Pro Arg Asp 
        675                 680                 685             


Gly Ala Phe Leu Val Arg Lys Arg Asn Glu Pro Asn Ser Tyr Ala Ile 
    690                 695                 700                 


Ser Phe Arg Ala Glu Gly Lys Ile Lys His Cys Arg Val Gln Gln Glu 
705                 710                 715                 720 


Gly Gln Thr Val Met Leu Gly Asn Ser Glu Phe Asp Ser Leu Val Asp 
                725                 730                 735     


Leu Ile Ser Tyr Tyr Glu Lys His Pro Leu Tyr Arg Lys Met Lys Leu 
            740                 745                 750         


Arg Tyr Pro Ile Asn Glu Glu Ala Leu Glu Lys Ile Gly Thr Ala Glu 
        755                 760                 765             


Pro Asp Tyr Gly Ala Leu Tyr Glu Gly Arg Asn Pro Gly Phe Tyr Val 
    770                 775                 780                 


Glu Ala Asn Pro Met Pro Thr Phe Lys Cys Ala Val Lys Ala Leu Phe 
785                 790                 795                 800 


Asp Tyr Lys Ala Gln Arg Glu Asp Glu Leu Thr Phe Ile Lys Ser Ala 
                805                 810                 815     


Ile Ile Gln Asn Val Glu Lys Gln Glu Gly Gly Trp Trp Arg Gly Asp 
            820                 825                 830         


Tyr Gly Gly Lys Lys Gln Leu Trp Phe Pro Ser Asn Tyr Val Glu Glu 
        835                 840                 845             


Met Val Asn Pro Val Ala Leu Glu Pro Glu Arg Glu His Leu Asp Glu 
    850                 855                 860                 


Asn Ser Pro Leu Gly Asp Leu Leu Arg Gly Val Leu Asp Val Pro Ala 
865                 870                 875                 880 


Cys Gln Ile Ala Ile Arg Pro Glu Gly Lys Asn Asn Arg Leu Phe Val 
                885                 890                 895     


Phe Ser Ile Ser Met Ala Ser Val Ala His Trp Ser Leu Asp Val Ala 
            900                 905                 910         


Ala Asp Ser Gln Glu Glu Leu Gln Asp Trp Val Lys Lys Ile Arg Glu 
        915                 920                 925             


Val Ala Gln Thr Ala Asp Ala Arg Leu Thr Glu Gly Lys Ile Met Glu 
    930                 935                 940                 


Arg Arg Lys Lys Ile Ala Leu Glu Leu Ser Glu Leu Val Val Tyr Cys 
945                 950                 955                 960 


Arg Pro Val Pro Phe Asp Glu Glu Lys Ile Gly Thr Glu Arg Ala Cys 
                965                 970                 975     


Tyr Arg Asp Met Ser Ser Phe Pro Glu Thr Lys Ala Glu Lys Tyr Val 
            980                 985                 990         


Asn Lys Ala Lys Gly Lys Lys Phe  Leu Gln Tyr Asn Arg  Leu Gln Leu 
        995                 1000                 1005             


Ser Arg  Ile Tyr Pro Lys Gly  Gln Arg Leu Asp Ser  Ser Asn Tyr 
    1010                 1015                 1020             


Asp Pro  Leu Pro Met Trp Ile  Cys Gly Ser Gln Leu  Val Ala Leu 
    1025                 1030                 1035             


Asn Phe  Gln Thr Pro Asp Lys  Pro Met Gln Met Asn  Gln Ala Leu 
    1040                 1045                 1050             


Phe Met  Thr Gly Arg His Cys  Gly Tyr Val Leu Gln  Pro Ser Thr 
    1055                 1060                 1065             


Met Arg  Asp Glu Ala Phe Asp  Pro Phe Asp Lys Ser  Ser Leu Arg 
    1070                 1075                 1080             


Gly Leu  Glu Pro Cys Ala Ile  Ser Ile Glu Val Leu  Gly Ala Arg 
    1085                 1090                 1095             


His Leu  Pro Lys Asn Gly Arg  Gly Ile Val Cys Pro  Phe Val Glu 
    1100                 1105                 1110             


Ile Glu  Val Ala Gly Ala Glu  Tyr Asp Ser Thr Lys  Gln Lys Thr 
    1115                 1120                 1125             


Glu Phe  Val Val Asp Asn Gly  Leu Asn Pro Val Trp  Pro Ala Lys 
    1130                 1135                 1140             


Pro Phe  His Phe Gln Ile Ser  Asn Pro Glu Phe Ala  Phe Leu Arg 
    1145                 1150                 1155             


Phe Val  Val Tyr Glu Glu Asp  Met Phe Ser Asp Gln  Asn Phe Leu 
    1160                 1165                 1170             


Ala Gln  Ala Thr Phe Pro Val  Lys Gly Leu Lys Thr  Gly Tyr Arg 
    1175                 1180                 1185             


Ala Val  Pro Leu Lys Asn Asn  Tyr Ser Glu Asp Leu  Glu Leu Ala 
    1190                 1195                 1200             


Ser Leu  Leu Ile Lys Ile Asp  Ile Phe Pro Ala Lys  Glu Asn Gly 
    1205                 1210                 1215             


Asp Leu  Ser Pro Phe Ser Gly  Thr Ser Leu Arg Glu  Arg Gly Ser 
    1220                 1225                 1230             


Asp Ala  Ser Gly Gln Leu Phe  His Gly Arg Ala Arg  Glu Gly Ser 
    1235                 1240                 1245             


Phe Glu  Ser Arg Tyr Gln Gln  Pro Phe Glu Asp Phe  Arg Ile Ser 
    1250                 1255                 1260             


Gln Glu  His Leu Ala Asp His  Phe Asp Ser Arg Glu  Arg Arg Ala 
    1265                 1270                 1275             


Pro Arg  Arg Thr Arg Val Asn  Gly Asp Asn Arg Leu  
    1280                 1285                 1290 


<210>  126
<211>  888
<212>  PRT
<213>  homo sapiens

<400>  126

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
1               5                   10                  15      


Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
            20                  25                  30          


Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
        35                  40                  45              


Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
    50                  55                  60                  


Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
65                  70                  75                  80  


Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                85                  90                  95      


Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
            100                 105                 110         


Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
        115                 120                 125             


Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
    130                 135                 140                 


Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
145                 150                 155                 160 


Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                165                 170                 175     


Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
            180                 185                 190         


Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
        195                 200                 205             


Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
    210                 215                 220                 


Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
225                 230                 235                 240 


Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                245                 250                 255     


Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
            260                 265                 270         


Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
        275                 280                 285             


Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
    290                 295                 300                 


Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
305                 310                 315                 320 


Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                325                 330                 335     


Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
            340                 345                 350         


Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
        355                 360                 365             


Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
    370                 375                 380                 


Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
385                 390                 395                 400 


Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                405                 410                 415     


Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
            420                 425                 430         


Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
        435                 440                 445             


Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
    450                 455                 460                 


Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
465                 470                 475                 480 


Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                485                 490                 495     


Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
            500                 505                 510         


Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu 
        515                 520                 525             


Asn Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu 
    530                 535                 540                 


Cys Leu Asp Glu Lys Glu Phe Gln Val Pro Met Ala Thr Thr Glu Gly 
545                 550                 555                 560 


Cys Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Gly Leu Gly 
                565                 570                 575     


Gly Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro 
            580                 585                 590         


Val Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp 
        595                 600                 605             


Leu Glu Thr Ser Glu Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser 
    610                 615                 620                 


Thr Ser Arg Phe Ala Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly 
625                 630                 635                 640 


Arg Asn Leu Tyr Ile Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly 
                645                 650                 655     


Met Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His 
            660                 665                 670         


Glu Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys 
        675                 680                 685             


Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys 
    690                 695                 700                 


Ser Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val 
705                 710                 715                 720 


Leu Lys Thr Thr Thr Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn 
                725                 730                 735     


Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His 
            740                 745                 750         


Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala 
        755                 760                 765             


Ala Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser 
    770                 775                 780                 


Gly Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile 
785                 790                 795                 800 


Glu Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala 
                805                 810                 815     


Cys Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly 
            820                 825                 830         


Glu Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala 
        835                 840                 845             


Gly Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Lys 
    850                 855                 860                 


Ser His Met Ile His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln 
865                 870                 875                 880 


Gly Ala Cys Thr Lys Lys Thr Ala 
                885             


<210>  127
<211>  146
<212>  PRT
<213>  homo sapiens

<400>  127

Met Pro Ser Lys Gly Pro Leu Gln Ser Val Gln Val Phe Gly Arg Lys 
1               5                   10                  15      


Lys Thr Ala Thr Ala Val Ala His Cys Lys Arg Gly Asn Gly Leu Ile 
            20                  25                  30          


Lys Val Asn Gly Arg Pro Leu Glu Met Ile Glu Pro Arg Thr Leu Gln 
        35                  40                  45              


Tyr Lys Leu Leu Glu Pro Val Leu Leu Leu Gly Lys Glu Arg Phe Ala 
    50                  55                  60                  


Gly Val Asp Ile Arg Val Arg Val Lys Gly Gly Gly His Val Ala Gln 
65                  70                  75                  80  


Ile Tyr Ala Ile Arg Gln Ser Ile Ser Lys Ala Leu Val Ala Tyr Tyr 
                85                  90                  95      


Gln Lys Tyr Val Asp Glu Ala Ser Lys Lys Glu Ile Lys Asp Ile Leu 
            100                 105                 110         


Ile Gln Tyr Asp Arg Thr Leu Leu Val Ala Asp Pro Arg Arg Cys Glu 
        115                 120                 125             


Ser Lys Lys Phe Gly Gly Pro Gly Ala Arg Ala Arg Tyr Gln Lys Ser 
    130                 135                 140                 


Tyr Arg 
145     


<210>  128
<211>  134
<212>  PRT
<213>  homo sapiens

<400>  128

Leu Thr Leu Asp Glu Lys Asp Pro Arg Arg Leu Phe Glu Gly Asn Ala 
1               5                   10                  15      


Leu Leu Arg Arg Leu Val Arg Ile Gly Val Leu Asp Glu Gly Lys Met 
            20                  25                  30          


Lys Leu Asp Tyr Ile Leu Gly Leu Lys Ile Glu Asp Phe Leu Glu Arg 
        35                  40                  45              


Arg Leu Gln Thr Gln Val Phe Lys Leu Gly Leu Ala Lys Ser Ile His 
    50                  55                  60                  


His Ala Arg Val Leu Ile Arg Gln Arg His Ile Arg Val Arg Lys Gln 
65                  70                  75                  80  


Val Val Asn Ile Pro Ser Phe Ile Val Arg Leu Asp Ser Gln Lys His 
                85                  90                  95      


Ile Asp Phe Ser Leu Arg Ser Pro Tyr Gly Gly Gly Arg Pro Gly Arg 
            100                 105                 110         


Val Lys Arg Lys Asn Ala Lys Lys Gly Gln Gly Gly Ala Gly Ala Gly 
        115                 120                 125             


Asp Asp Glu Glu Glu Asp 
    130                 


<210>  129
<211>  156
<212>  PRT
<213>  homo sapiens

<400>  129

Met Ala Pro Lys Ala Lys Lys Glu Ala Pro Ala Pro Pro Lys Ala Glu 
1               5                   10                  15      


Ala Lys Ala Lys Ala Leu Lys Ala Lys Lys Ala Val Leu Lys Gly Val 
            20                  25                  30          


His Ser His Lys Lys Lys Lys Ile Arg Thr Ser Pro Thr Phe Arg Arg 
        35                  40                  45              


Pro Lys Thr Leu Arg Leu Arg Arg Gln Pro Lys Tyr Pro Arg Lys Ser 
    50                  55                  60                  


Ala Pro Arg Arg Asn Lys Leu Asp His Tyr Ala Ile Ile Lys Phe Pro 
65                  70                  75                  80  


Leu Thr Thr Glu Ser Ala Met Lys Lys Ile Glu Asp Asn Asn Thr Leu 
                85                  90                  95      


Val Phe Ile Val Asp Val Lys Ala Asn Lys His Gln Ile Lys Gln Ala 
            100                 105                 110         


Val Lys Lys Leu Tyr Asp Ile Asp Val Ala Lys Val Asn Thr Leu Ile 
        115                 120                 125             


Arg Pro Asp Gly Glu Lys Lys Ala Tyr Val Arg Leu Ala Pro Asp Tyr 
    130                 135                 140                 


Asp Ala Leu Asp Val Ala Asn Lys Ile Gly Ile Ile 
145                 150                 155     


<210>  130
<211>  5058
<212>  PRT
<213>  homo sapiens

<400>  130

Met Gly His Ala Gly Cys Gln Phe Lys Ala Leu Leu Trp Lys Asn Trp 
1               5                   10                  15      


Leu Cys Arg Leu Arg Asn Pro Val Leu Phe Leu Ala Glu Phe Phe Trp 
            20                  25                  30          


Pro Cys Ile Leu Phe Val Ile Leu Thr Val Leu Arg Phe Gln Glu Pro 
        35                  40                  45              


Pro Arg Tyr Arg Asp Ile Cys Tyr Leu Gln Pro Arg Asp Leu Pro Ser 
    50                  55                  60                  


Cys Gly Val Ile Pro Phe Val Gln Ser Leu Leu Cys Asn Thr Gly Ser 
65                  70                  75                  80  


Arg Cys Arg Asn Phe Ser Tyr Glu Gly Ser Met Glu His His Phe Arg 
                85                  90                  95      


Leu Ser Arg Phe Gln Thr Ala Ala Asp Pro Lys Lys Val Asn Asn Leu 
            100                 105                 110         


Ala Phe Leu Lys Glu Ile Gln Asp Leu Ala Glu Glu Ile His Gly Met 
        115                 120                 125             


Met Asp Lys Ala Lys Asn Leu Lys Arg Leu Trp Val Glu Arg Ser Asn 
    130                 135                 140                 


Thr Pro Asp Ser Ser Tyr Gly Ser Ser Phe Phe Thr Met Asp Leu Asn 
145                 150                 155                 160 


Lys Thr Glu Glu Val Ile Leu Lys Leu Glu Ser Leu His Gln Gln Pro 
                165                 170                 175     


His Ile Trp Asp Phe Leu Leu Leu Leu Pro Arg Leu His Thr Ser His 
            180                 185                 190         


Asp His Val Glu Asp Gly Met Asp Val Ala Val Asn Leu Leu Gln Thr 
        195                 200                 205             


Ile Leu Asn Ser Leu Ile Ser Leu Glu Asp Leu Asp Trp Leu Pro Leu 
    210                 215                 220                 


Asn Gln Thr Phe Ser Gln Val Ser Glu Leu Val Leu Asn Val Thr Ile 
225                 230                 235                 240 


Ser Thr Leu Thr Phe Leu Gln Gln His Gly Val Ala Val Thr Glu Pro 
                245                 250                 255     


Val Tyr His Leu Ser Met Gln Asn Ile Val Trp Asp Pro Gln Lys Val 
            260                 265                 270         


Gln Tyr Asp Leu Lys Ser Gln Phe Gly Phe Asp Asp Leu His Thr Glu 
        275                 280                 285             


Gln Ile Leu Asn Ser Ser Ala Glu Leu Lys Glu Ile Pro Thr Asp Thr 
    290                 295                 300                 


Ser Leu Glu Lys Met Val Cys Ser Val Leu Ser Ser Thr Ser Glu Asp 
305                 310                 315                 320 


Glu Ala Glu Lys Trp Gly His Val Gly Gly Cys His Pro Lys Trp Ser 
                325                 330                 335     


Glu Ala Lys Asn Tyr Leu Val His Ala Val Ser Trp Leu Arg Val Tyr 
            340                 345                 350         


Gln Gln Val Phe Val Gln Trp Gln Gln Gly Ser Leu Leu Gln Lys Thr 
        355                 360                 365             


Leu Thr Gly Met Gly His Ser Leu Glu Ala Leu Arg Asn Gln Phe Glu 
    370                 375                 380                 


Glu Glu Ser Lys Pro Trp Lys Val Val Glu Ala Leu His Thr Ala Leu 
385                 390                 395                 400 


Leu Leu Leu Asn Asp Ser Leu Ser Ala Asp Gly Pro Lys Asp Asn His 
                405                 410                 415     


Thr Phe Pro Lys Ile Leu Gln His Leu Trp Lys Leu Gln Ser Leu Leu 
            420                 425                 430         


Gln Asn Leu Pro Gln Trp Pro Ala Leu Lys Arg Phe Leu Gln Leu Asp 
        435                 440                 445             


Gly Ala Leu Arg Asn Ala Ile Ala Gln Asn Leu His Phe Val Gln Glu 
    450                 455                 460                 


Val Leu Ile Cys Leu Glu Thr Ser Ala Asn Asp Phe Lys Trp Phe Glu 
465                 470                 475                 480 


Leu Asn Gln Leu Lys Leu Glu Lys Asp Val Phe Phe Trp Glu Leu Lys 
                485                 490                 495     


Gln Met Leu Ala Lys Asn Ala Val Cys Pro Asn Gly Arg Phe Ser Glu 
            500                 505                 510         


Lys Glu Val Phe Leu Pro Pro Gly Asn Ser Ser Ile Trp Gly Gly Leu 
        515                 520                 525             


Gln Gly Leu Leu Cys Tyr Cys Asn Ser Ser Glu Thr Ser Val Leu Asn 
    530                 535                 540                 


Lys Leu Leu Gly Ser Val Glu Asp Ala Asp Arg Ile Leu Gln Glu Val 
545                 550                 555                 560 


Ile Thr Trp His Lys Asn Met Ser Val Leu Ile Pro Glu Glu Tyr Leu 
                565                 570                 575     


Asp Trp Gln Glu Leu Glu Met Gln Leu Ser Glu Ala Ser Leu Ser Cys 
            580                 585                 590         


Thr Arg Leu Phe Leu Leu Leu Gly Ala Asp Pro Ser Pro Glu Asn Asp 
        595                 600                 605             


Val Phe Ser Ser Asp Cys Lys His Gln Leu Val Ser Thr Val Ile Phe 
    610                 615                 620                 


His Thr Leu Glu Lys Thr Gln Phe Phe Leu Glu Gln Ala Tyr Tyr Trp 
625                 630                 635                 640 


Lys Ala Phe Lys Lys Phe Ile Arg Lys Thr Cys Glu Val Ala Gln Tyr 
                645                 650                 655     


Val Asn Met Gln Glu Ser Phe Gln Asn Arg Leu Leu Ala Phe Pro Glu 
            660                 665                 670         


Glu Ser Pro Cys Phe Glu Glu Asn Met Asp Trp Lys Met Ile Ser Asp 
        675                 680                 685             


Asn Tyr Phe Gln Phe Leu Asn Asn Leu Leu Lys Ser Pro Thr Ala Ser 
    690                 695                 700                 


Ile Ser Arg Ala Leu Asn Phe Thr Lys His Leu Leu Met Met Glu Lys 
705                 710                 715                 720 


Lys Leu His Thr Leu Glu Asp Glu Gln Met Asn Phe Leu Leu Ser Phe 
                725                 730                 735     


Val Glu Phe Phe Glu Lys Leu Leu Leu Pro Asn Leu Phe Asp Ser Ser 
            740                 745                 750         


Ile Val Pro Ser Phe His Ser Leu Pro Ser Leu Thr Glu Asp Ile Leu 
        755                 760                 765             


Asn Ile Ser Ser Leu Trp Thr Asn His Leu Lys Ser Leu Lys Arg Asp 
    770                 775                 780                 


Pro Ser Ala Thr Asp Ala Gln Lys Leu Leu Glu Phe Gly Asn Glu Val 
785                 790                 795                 800 


Ile Trp Lys Met Gln Thr Leu Gly Ser His Trp Ile Arg Lys Glu Pro 
                805                 810                 815     


Lys Asn Leu Leu Arg Phe Ile Glu Leu Ile Leu Phe Glu Ile Asn Pro 
            820                 825                 830         


Lys Leu Leu Glu Leu Trp Ala Tyr Gly Ile Ser Lys Gly Lys Arg Ala 
        835                 840                 845             


Lys Leu Glu Asn Phe Phe Thr Leu Leu Asn Phe Ser Val Pro Glu Asn 
    850                 855                 860                 


Glu Ile Leu Ser Thr Ser Phe Asn Phe Ser Gln Leu Phe His Ser Asp 
865                 870                 875                 880 


Trp Pro Lys Ser Pro Ala Met Asn Ile Asp Phe Val Arg Leu Ser Glu 
                885                 890                 895     


Ala Ile Ile Thr Ser Leu His Glu Phe Gly Phe Leu Glu Gln Glu Gln 
            900                 905                 910         


Ile Ser Glu Ala Leu Asn Thr Val Tyr Ala Ile Arg Asn Ala Ser Asp 
        915                 920                 925             


Leu Phe Ser Ala Leu Ser Glu Pro Gln Lys Gln Glu Val Asp Lys Ile 
    930                 935                 940                 


Leu Thr His Ile His Leu Asn Val Phe Gln Asp Lys Asp Ser Ala Leu 
945                 950                 955                 960 


Leu Leu Gln Ile Tyr Ser Ser Phe Tyr Arg Tyr Ile Tyr Glu Leu Leu 
                965                 970                 975     


Asn Ile Gln Ser Arg Gly Ser Ser Leu Thr Phe Leu Thr Gln Ile Ser 
            980                 985                 990         


Lys His Ile Leu Asp Ile Ile Lys  Gln Phe Asn Phe Gln  Asn Ile Ser 
        995                 1000                 1005             


Lys Ala  Phe Ala Phe Leu Phe  Lys Thr Ala Glu Val  Leu Gly Gly 
    1010                 1015                 1020             


Ile Ser  Asn Val Ser Tyr Cys  Gln Gln Leu Leu Ser  Ile Phe Asn 
    1025                 1030                 1035             


Phe Leu  Glu Leu Gln Ala Gln  Ser Phe Met Ser Thr  Glu Gly Gln 
    1040                 1045                 1050             


Glu Leu  Glu Val Ile His Thr  Thr Leu Thr Gly Leu  Lys Gln Leu 
    1055                 1060                 1065             


Leu Ile  Ile Asp Glu Asp Phe  Arg Ile Ser Leu Phe  Gln Tyr Met 
    1070                 1075                 1080             


Ser Gln  Phe Phe Asn Ser Ser  Val Glu Asp Leu Leu  Asp Asn Lys 
    1085                 1090                 1095             


Cys Leu  Ile Ser Asp Asn Lys  His Ile Ser Ser Val  Asn Tyr Ser 
    1100                 1105                 1110             


Thr Ser  Glu Glu Ser Ser Phe  Val Phe Pro Leu Ala  Gln Ile Phe 
    1115                 1120                 1125             


Ser Asn  Leu Ser Ala Asn Val  Ser Val Phe Asn Lys  Phe Met Ser 
    1130                 1135                 1140             


Ile His  Cys Thr Val Ser Trp  Leu Gln Met Trp Thr  Glu Ile Trp 
    1145                 1150                 1155             


Glu Thr  Ile Ser Gln Leu Phe  Lys Phe Asp Met Asn  Val Phe Thr 
    1160                 1165                 1170             


Ser Leu  His His Gly Phe Thr  Gln Leu Leu Asp Glu  Leu Glu Asp 
    1175                 1180                 1185             


Asp Val  Lys Val Ser Lys Ser  Cys Gln Gly Ile Leu  Pro Thr His 
    1190                 1195                 1200             


Asn Val  Ala Arg Leu Ile Leu  Asn Leu Phe Lys Asn  Val Thr Gln 
    1205                 1210                 1215             


Ala Asn  Asp Phe His Asn Trp  Glu Asp Phe Leu Asp  Leu Arg Asp 
    1220                 1225                 1230             


Phe Leu  Val Ala Leu Gly Asn  Ala Leu Val Ser Val  Lys Lys Leu 
    1235                 1240                 1245             


Asn Leu  Glu Gln Val Glu Lys  Ser Leu Phe Thr Met  Glu Ala Ala 
    1250                 1255                 1260             


Leu His  Gln Leu Lys Thr Phe  Pro Phe Asn Glu Ser  Thr Ser Arg 
    1265                 1270                 1275             


Glu Phe  Leu Asn Ser Leu Leu  Glu Val Phe Ile Glu  Phe Ser Ser 
    1280                 1285                 1290             


Thr Ser  Glu Tyr Ile Val Arg  Asn Leu Asp Ser Ile  Asn Asp Phe 
    1295                 1300                 1305             


Leu Ser  Asn Asn Leu Thr Asn  Tyr Gly Glu Lys Phe  Glu Asn Ile 
    1310                 1315                 1320             


Ile Thr  Glu Leu Arg Glu Ala  Ile Val Phe Leu Arg  Asn Val Ser 
    1325                 1330                 1335             


His Asp  Arg Asp Leu Phe Ser  Cys Ala Asp Ile Phe  Gln Asn Val 
    1340                 1345                 1350             


Thr Glu  Cys Ile Leu Glu Asp  Gly Phe Leu Tyr Val  Asn Thr Ser 
    1355                 1360                 1365             


Gln Arg  Met Leu Arg Ile Leu  Asp Thr Leu Asn Ser  Thr Phe Ser 
    1370                 1375                 1380             


Ser Glu  Asn Thr Ile Ser Ser  Leu Lys Gly Cys Ile  Val Trp Leu 
    1385                 1390                 1395             


Asp Val  Ile Asn His Leu Tyr  Leu Leu Ser Asn Ser  Ser Phe Ser 
    1400                 1405                 1410             


Gln Gly  Arg Leu Gln Asn Ile  Leu Gly Asn Phe Arg  Asp Ile Glu 
    1415                 1420                 1425             


Asn Lys  Met Asn Ser Ile Leu  Lys Ile Val Thr Trp  Val Leu Asn 
    1430                 1435                 1440             


Ile Lys  Lys Pro Leu Cys Ser  Ser Asn Gly Ser His  Ile Asn Cys 
    1445                 1450                 1455             


Val Asn  Ile Tyr Leu Lys Asp  Val Thr Asp Phe Leu  Asn Ile Val 
    1460                 1465                 1470             


Leu Thr  Thr Val Phe Glu Lys  Glu Lys Lys Pro Lys  Phe Glu Ile 
    1475                 1480                 1485             


Leu Leu  Ala Leu Leu Asn Asp  Ser Thr Lys Gln Val  Arg Met Ser 
    1490                 1495                 1500             


Ile Asn  Asn Leu Thr Thr Asp  Phe Asp Phe Ala Ser  Gln Ser Asn 
    1505                 1510                 1515             


Trp Arg  Tyr Phe Thr Glu Leu  Ile Leu Arg Pro Ile  Glu Met Ser 
    1520                 1525                 1530             


Asp Glu  Ile Pro Asn Gln Phe  Gln Asn Ile Trp Leu  His Leu Ile 
    1535                 1540                 1545             


Thr Leu  Gly Lys Glu Phe Gln  Lys Leu Val Lys Gly  Ile Tyr Phe 
    1550                 1555                 1560             


Asn Ile  Leu Glu Asn Asn Ser  Ser Ser Lys Thr Glu  Asn Leu Leu 
    1565                 1570                 1575             


Asn Ile  Phe Ala Thr Ser Pro  Lys Glu Lys Asp Val  Asn Ser Val 
    1580                 1585                 1590             


Gly Asn  Ser Ile Tyr His Leu  Ala Ser Tyr Leu Ala  Phe Ser Leu 
    1595                 1600                 1605             


Ser His  Asp Leu Gln Asn Ser  Pro Lys Ile Ile Ile  Ser Pro Glu 
    1610                 1615                 1620             


Ile Met  Lys Ala Thr Gly Leu  Gly Ile Gln Leu Ile  Arg Asp Val 
    1625                 1630                 1635             


Phe Asn  Ser Leu Met Pro Val  Val His His Thr Ser  Pro Gln Asn 
    1640                 1645                 1650             


Ala Gly  Tyr Met Gln Ala Leu  Lys Lys Val Thr Ser  Val Met Arg 
    1655                 1660                 1665             


Thr Leu  Lys Lys Ala Asp Ile  Asp Leu Leu Val Asp  Gln Leu Glu 
    1670                 1675                 1680             


Gln Val  Ser Val Asn Leu Met  Asp Phe Phe Lys Asn  Ile Ser Ser 
    1685                 1690                 1695             


Val Gly  Thr Gly Asn Leu Val  Val Asn Leu Leu Val  Gly Leu Met 
    1700                 1705                 1710             


Glu Lys  Phe Ala Asp Ser Ser  His Ser Trp Asn Val  Asn His Leu 
    1715                 1720                 1725             


Leu Gln  Leu Ser Arg Leu Phe  Pro Lys Asp Val Val  Asp Ala Val 
    1730                 1735                 1740             


Ile Asp  Val Tyr Tyr Val Leu  Pro His Ala Val Arg  Leu Leu Gln 
    1745                 1750                 1755             


Gly Val  Pro Gly Lys Asn Ile  Thr Glu Gly Leu Lys  Asp Val Tyr 
    1760                 1765                 1770             


Ser Phe  Thr Leu Leu His Gly  Ile Thr Ile Ser Asn  Ile Thr Lys 
    1775                 1780                 1785             


Glu Asp  Phe Ala Ile Val Ile  Lys Ile Leu Leu Asp  Thr Ile Glu 
    1790                 1795                 1800             


Leu Val  Ser Asp Lys Pro Asp  Ile Ile Ser Glu Ala  Leu Ala Cys 
    1805                 1810                 1815             


Phe Pro  Val Val Trp Cys Trp  Asn His Thr Asn Ser  Gly Phe Arg 
    1820                 1825                 1830             


Gln Asn  Ser Lys Ile Asp Pro  Cys Asn Val His Gly  Leu Met Ser 
    1835                 1840                 1845             


Ser Ser  Phe Tyr Gly Lys Val  Ala Ser Ile Leu Asp  His Phe His 
    1850                 1855                 1860             


Leu Ser  Pro Gln Gly Glu Asp  Ser Pro Cys Ser Asn  Glu Ser Ser 
    1865                 1870                 1875             


Arg Met  Glu Ile Thr Arg Lys  Val Val Cys Ile Ile  His Glu Leu 
    1880                 1885                 1890             


Val Asp  Trp Asn Ser Ile Leu  Leu Glu Leu Ser Glu  Val Phe His 
    1895                 1900                 1905             


Val Asn  Ile Ser Leu Val Lys  Thr Val Gln Lys Phe  Trp His Lys 
    1910                 1915                 1920             


Ile Leu  Pro Phe Val Pro Pro  Ser Ile Asn Gln Thr  Arg Asp Ser 
    1925                 1930                 1935             


Ile Ser  Glu Leu Cys Pro Ser  Gly Ser Ile Lys Gln  Val Ala Leu 
    1940                 1945                 1950             


Gln Ile  Ile Glu Lys Leu Lys  Asn Val Asn Phe Thr  Lys Val Thr 
    1955                 1960                 1965             


Ser Gly  Glu Asn Ile Leu Asp  Lys Leu Ser Ser Leu  Asn Lys Ile 
    1970                 1975                 1980             


Leu Asn  Ile Asn Glu Asp Thr  Glu Thr Ser Val Gln  Asn Ile Ile 
    1985                 1990                 1995             


Ser Ser  Asn Leu Glu Arg Thr  Val Gln Leu Ile Ser  Glu Asp Trp 
    2000                 2005                 2010             


Ser Leu  Glu Lys Ser Thr His  Asn Leu Leu Ser Leu  Phe Met Met 
    2015                 2020                 2025             


Leu Gln  Asn Ala Asn Val Thr  Gly Ser Ser Leu Glu  Ala Leu Ser 
    2030                 2035                 2040             


Ser Phe  Ile Glu Lys Ser Glu  Thr Pro Tyr Asn Phe  Glu Glu Leu 
    2045                 2050                 2055             


Trp Pro  Lys Phe Gln Gln Ile  Met Lys Asp Leu Thr  Gln Asp Phe 
    2060                 2065                 2070             


Arg Ile  Arg His Leu Leu Ser  Glu Met Asn Lys Gly  Ile Lys Ser 
    2075                 2080                 2085             


Ile Asn  Ser Met Ala Leu Gln  Lys Ile Thr Leu Gln  Phe Ala His 
    2090                 2095                 2100             


Phe Leu  Glu Ile Leu Asp Ser  Pro Ser Leu Lys Thr  Leu Glu Ile 
    2105                 2110                 2115             


Ile Glu  Asp Phe Leu Leu Val  Thr Lys Asn Trp Leu  Gln Glu Tyr 
    2120                 2125                 2130             


Ala Asn  Glu Asp Tyr Ser Arg  Met Ile Glu Thr Leu  Phe Ile Pro 
    2135                 2140                 2145             


Val Thr  Asn Glu Ser Ser Thr  Glu Asp Ile Ala Leu  Leu Ala Lys 
    2150                 2155                 2160             


Ala Ile  Ala Thr Phe Trp Gly  Ser Leu Lys Asn Ile  Ser Arg Ala 
    2165                 2170                 2175             


Gly Asn  Phe Asp Val Ala Phe  Leu Thr His Leu Leu  Asn Gln Glu 
    2180                 2185                 2190             


Gln Leu  Thr Asn Phe Ser Val  Val Gln Leu Leu Phe  Glu Asn Ile 
    2195                 2200                 2205             


Leu Ile  Asn Leu Ile Asn Asn  Leu Ala Gly Asn Ser  Gln Glu Ala 
    2210                 2215                 2220             


Ala Trp  Asn Leu Asn Asp Thr  Asp Leu Gln Ile Met  Asn Phe Ile 
    2225                 2230                 2235             


Asn Leu  Ile Leu Asn His Met  Gln Ser Glu Thr Ser  Arg Lys Thr 
    2240                 2245                 2250             


Val Leu  Ser Leu Arg Ser Ile  Val Asp Phe Thr Glu  Gln Phe Leu 
    2255                 2260                 2265             


Lys Thr  Phe Phe Ser Leu Phe  Leu Lys Glu Asp Ser  Glu Asn Lys 
    2270                 2275                 2280             


Ile Ser  Leu Leu Leu Lys Tyr  Phe His Lys Asp Val  Ile Ala Glu 
    2285                 2290                 2295             


Met Ser  Phe Val Pro Lys Asp  Lys Ile Leu Glu Ile  Leu Lys Leu 
    2300                 2305                 2310             


Asp Gln  Phe Leu Thr Leu Met  Ile Gln Asp Arg Leu  Met Asn Ile 
    2315                 2320                 2325             


Phe Ser  Ser Leu Lys Glu Thr  Ile Tyr His Leu Met  Lys Ser Ser 
    2330                 2335                 2340             


Phe Ile  Leu Asp Asn Gly Glu  Phe Tyr Phe Asp Thr  His Gln Gly 
    2345                 2350                 2355             


Leu Lys  Phe Met Gln Asp Leu  Phe Asn Ala Leu Leu  Arg Glu Thr 
    2360                 2365                 2370             


Ser Met  Lys Asn Lys Thr Glu  Asn Asn Ile Asp Phe  Phe Thr Val 
    2375                 2380                 2385             


Val Ser  Gln Leu Phe Phe His  Val Asn Lys Ser Glu  Asp Leu Phe 
    2390                 2395                 2400             


Lys Leu  Asn Gln Asp Leu Gly  Ser Ala Leu His Leu  Val Arg Glu 
    2405                 2410                 2415             


Cys Ser  Thr Glu Met Ala Arg  Leu Leu Asp Thr Ile  Leu His Ser 
    2420                 2425                 2430             


Pro Asn  Lys Asp Phe Tyr Ala  Leu Tyr Pro Thr Leu  Gln Glu Val 
    2435                 2440                 2445             


Ile Leu  Ala Asn Leu Thr Asp  Leu Leu Phe Phe Ile  Asn Asn Ser 
    2450                 2455                 2460             


Phe Pro  Leu Arg Asn Arg Ala  Thr Leu Glu Ile Thr  Lys Arg Leu 
    2465                 2470                 2475             


Val Gly  Ala Ile Ser Arg Ala  Ser Glu Glu Ser His  Val Leu Lys 
    2480                 2485                 2490             


Pro Leu  Leu Glu Met Ser Gly  Thr Leu Val Met Leu  Leu Asn Asp 
    2495                 2500                 2505             


Ser Ala  Asp Leu Arg Asp Leu  Ala Thr Ser Met Asp  Ser Ile Val 
    2510                 2515                 2520             


Lys Leu  Leu Lys Leu Val Lys  Lys Val Ser Gly Lys  Met Ser Thr 
    2525                 2530                 2535             


Val Phe  Lys Thr His Phe Ile  Ser Asn Thr Lys Asp  Ser Val Lys 
    2540                 2545                 2550             


Phe Phe  Asp Thr Leu Tyr Ser  Ile Met Gln Gln Ser  Val Gln Asn 
    2555                 2560                 2565             


Leu Val  Lys Glu Ile Ala Thr  Leu Lys Lys Ile Asp  His Phe Thr 
    2570                 2575                 2580             


Phe Glu  Lys Ile Asn Asp Leu  Leu Val Pro Phe Leu  Asp Leu Ala 
    2585                 2590                 2595             


Phe Glu  Met Ile Gly Val Glu  Pro Tyr Ile Ser Ser  Asn Ser Asp 
    2600                 2605                 2610             


Ile Phe  Ser Met Ser Pro Ser  Ile Leu Ser Tyr Met  Asn Gln Ser 
    2615                 2620                 2625             


Lys Asp  Phe Ser Asp Ile Leu  Glu Glu Ile Ala Glu  Phe Leu Thr 
    2630                 2635                 2640             


Ser Val  Lys Met Asn Leu Glu  Asp Met Arg Ser Leu  Ala Val Ala 
    2645                 2650                 2655             


Phe Asn  Asn Glu Thr Gln Thr  Phe Ser Met Asp Ser  Val Asn Leu 
    2660                 2665                 2670             


Arg Glu  Glu Ile Leu Gly Cys  Leu Val Pro Ile Asn  Asn Ile Thr 
    2675                 2680                 2685             


Asn Gln  Met Asp Phe Leu Tyr  Pro Asn Pro Ile Ser  Thr His Ser 
    2690                 2695                 2700             


Gly Pro  Gln Asp Ile Lys Trp  Glu Ile Ile His Glu  Val Ile Leu 
    2705                 2710                 2715             


Phe Leu  Asp Lys Ile Leu Ser  Gln Asn Ser Thr Glu  Ile Gly Ser 
    2720                 2725                 2730             


Phe Leu  Lys Met Val Ile Cys  Leu Thr Leu Glu Ala  Leu Trp Lys 
    2735                 2740                 2745             


Asn Leu  Lys Lys Asp Asn Trp  Asn Val Ser Asn Val  Leu Met Thr 
    2750                 2755                 2760             


Phe Thr  Gln His Pro Asn Asn  Leu Leu Lys Thr Ile  Glu Thr Val 
    2765                 2770                 2775             


Leu Glu  Ala Ser Ser Gly Ile  Lys Ser Asp Tyr Glu  Gly Asp Leu 
    2780                 2785                 2790             


Asn Lys  Ser Leu Tyr Phe Asp  Thr Pro Leu Ser Gln  Asn Ile Thr 
    2795                 2800                 2805             


His His  Gln Leu Glu Lys Ala  Ile His Asn Val Leu  Ser Arg Ile 
    2810                 2815                 2820             


Ala Leu  Trp Arg Lys Gly Leu  Arg Phe Asn Asn Ser  Glu Trp Ile 
    2825                 2830                 2835             


Thr Ser  Thr Arg Thr Leu Phe  Gln Pro Leu Phe Glu  Ile Phe Ile 
    2840                 2845                 2850             


Lys Ala  Thr Thr Gly Lys Asn  Val Thr Ser Glu Lys  Glu Glu Arg 
    2855                 2860                 2865             


Thr Glu  Lys Glu Met Ile Asp  Phe Pro Tyr Ser Phe  Lys Pro Phe 
    2870                 2875                 2880             


Phe Cys  Leu Glu Lys Tyr Leu  Gly Gly Leu Phe Val  Leu Thr Lys 
    2885                 2890                 2895             


Tyr Trp  Gln Gln Ile Pro Leu  Thr Asp Gln Ser Val  Val Glu Ile 
    2900                 2905                 2910             


Cys Glu  Val Phe Gln Gln Thr  Val Lys Pro Ser Glu  Ala Met Glu 
    2915                 2920                 2925             


Met Leu  Gln Lys Val Lys Met  Met Val Val Arg Val  Leu Thr Ile 
    2930                 2935                 2940             


Val Ala  Glu Asn Pro Ser Trp  Thr Lys Asp Ile Leu  Cys Ala Thr 
    2945                 2950                 2955             


Leu Ser  Cys Lys Gln Asn Gly  Ile Arg His Leu Ile  Leu Ser Ala 
    2960                 2965                 2970             


Ile Gln  Gly Val Thr Leu Ala  Gln Asp His Phe Gln  Glu Ile Glu 
    2975                 2980                 2985             


Lys Ile  Trp Ser Ser Pro Asn  Gln Leu Asn Cys Glu  Ser Leu Ser 
    2990                 2995                 3000             


Lys Asn  Leu Ser Ser Thr Leu  Glu Ser Phe Lys Ser  Ser Leu Glu 
    3005                 3010                 3015             


Asn Ala  Thr Gly Gln Asp Cys  Thr Ser Gln Pro Arg  Leu Glu Thr 
    3020                 3025                 3030             


Val Gln  Gln His Leu Tyr Met  Leu Ala Lys Ser Leu  Glu Glu Thr 
    3035                 3040                 3045             


Trp Ser  Ser Gly Asn Pro Ile  Met Thr Phe Leu Ser  Asn Phe Thr 
    3050                 3055                 3060             


Val Thr  Glu Asp Val Lys Ile  Lys Asp Leu Met Lys  Asn Ile Thr 
    3065                 3070                 3075             


Lys Leu  Thr Glu Glu Leu Arg  Ser Ser Ile Gln Ile  Ser Asn Glu 
    3080                 3085                 3090             


Thr Ile  His Ser Ile Leu Glu  Ala Asn Ile Ser His  Ser Lys Val 
    3095                 3100                 3105             


Leu Phe  Ser Ala Leu Thr Val  Ala Leu Ser Gly Lys  Cys Asp Gln 
    3110                 3115                 3120             


Glu Ile  Leu His Leu Leu Leu  Thr Phe Pro Lys Gly  Glu Lys Ser 
    3125                 3130                 3135             


Trp Ile  Ala Ala Glu Glu Leu  Cys Ser Leu Pro Gly  Ser Lys Val 
    3140                 3145                 3150             


Tyr Ser  Leu Ile Val Leu Leu  Ser Arg Asn Leu Asp  Val Arg Ala 
    3155                 3160                 3165             


Phe Ile  Tyr Lys Thr Leu Met  Pro Ser Glu Ala Asn  Gly Leu Leu 
    3170                 3175                 3180             


Asn Ser  Leu Leu Asp Ile Val  Ser Ser Leu Ser Ala  Leu Leu Ala 
    3185                 3190                 3195             


Lys Ala  Gln His Val Phe Glu  Tyr Leu Pro Glu Phe  Leu His Thr 
    3200                 3205                 3210             


Phe Lys  Ile Thr Ala Leu Leu  Glu Thr Leu Asp Phe  Gln Gln Val 
    3215                 3220                 3225             


Ser Gln  Asn Val Gln Ala Arg  Ser Ser Ala Phe Gly  Ser Phe Gln 
    3230                 3235                 3240             


Phe Val  Met Lys Met Val Cys  Lys Asp Gln Ala Ser  Phe Leu Ser 
    3245                 3250                 3255             


Asp Ser  Asn Met Phe Ile Asn  Leu Pro Arg Val Lys  Glu Leu Leu 
    3260                 3265                 3270             


Glu Asp  Asp Lys Glu Lys Phe  Asn Ile Pro Glu Asp  Ser Thr Pro 
    3275                 3280                 3285             


Phe Cys  Leu Lys Leu Tyr Gln  Glu Ile Leu Gln Leu  Pro Asn Gly 
    3290                 3295                 3300             


Ala Leu  Val Trp Thr Phe Leu  Lys Pro Ile Leu His  Gly Lys Ile 
    3305                 3310                 3315             


Leu Tyr  Thr Pro Asn Thr Pro  Glu Ile Asn Lys Val  Ile Gln Lys 
    3320                 3325                 3330             


Ala Asn  Tyr Thr Phe Tyr Ile  Val Asp Lys Leu Lys  Thr Leu Ser 
    3335                 3340                 3345             


Glu Thr  Leu Leu Glu Met Ser  Ser Leu Phe Gln Arg  Ser Gly Ser 
    3350                 3355                 3360             


Gly Gln  Met Phe Asn Gln Leu  Gln Glu Ala Leu Arg  Asn Lys Phe 
    3365                 3370                 3375             


Val Arg  Asn Phe Val Glu Asn  Gln Leu His Ile Asp  Val Asp Lys 
    3380                 3385                 3390             


Leu Thr  Glu Lys Leu Gln Thr  Tyr Gly Gly Leu Leu  Asp Glu Met 
    3395                 3400                 3405             


Phe Asn  His Ala Gly Ala Gly  Arg Phe Arg Phe Leu  Gly Ser Ile 
    3410                 3415                 3420             


Leu Val  Asn Leu Ser Ser Cys  Val Ala Leu Asn Arg  Phe Gln Ala 
    3425                 3430                 3435             


Leu Gln  Ser Val Asp Ile Leu  Glu Thr Lys Ala His  Glu Leu Leu 
    3440                 3445                 3450             


Gln Gln  Asn Ser Phe Leu Ala  Ser Ile Ile Phe Ser  Asn Ser Leu 
    3455                 3460                 3465             


Phe Asp  Lys Asn Phe Arg Ser  Glu Ser Val Lys Leu  Pro Pro His 
    3470                 3475                 3480             


Val Ser  Tyr Thr Ile Arg Thr  Asn Val Leu Tyr Ser  Val Arg Thr 
    3485                 3490                 3495             


Asp Val  Val Lys Asn Pro Ser  Trp Lys Phe His Pro  Gln Asn Leu 
    3500                 3505                 3510             


Pro Ala  Asp Gly Phe Lys Tyr  Asn Tyr Val Phe Ala  Pro Leu Gln 
    3515                 3520                 3525             


Asp Met  Ile Glu Arg Ala Ile  Ile Leu Val Gln Thr  Gly Gln Glu 
    3530                 3535                 3540             


Ala Leu  Glu Pro Ala Ala Gln  Thr Gln Ala Ala Pro  Tyr Pro Cys 
    3545                 3550                 3555             


His Thr  Ser Asp Leu Phe Leu  Asn Asn Val Gly Phe  Phe Phe Pro 
    3560                 3565                 3570             


Leu Ile  Met Met Leu Thr Trp  Met Val Ser Val Ala  Ser Met Val 
    3575                 3580                 3585             


Arg Lys  Leu Val Tyr Glu Gln  Glu Ile Gln Ile Glu  Glu Tyr Met 
    3590                 3595                 3600             


Arg Met  Met Gly Val His Pro  Val Ile His Phe Leu  Ala Trp Phe 
    3605                 3610                 3615             


Leu Glu  Asn Met Ala Val Leu  Thr Ile Ser Ser Ala  Thr Leu Ala 
    3620                 3625                 3630             


Ile Val  Leu Lys Thr Ser Gly  Ile Phe Ala His Ser  Asn Thr Phe 
    3635                 3640                 3645             


Ile Val  Phe Leu Phe Leu Leu  Asp Phe Gly Met Ser  Val Val Met 
    3650                 3655                 3660             


Leu Ser  Tyr Leu Leu Ser Ala  Phe Phe Ser Gln Ala  Asn Thr Ala 
    3665                 3670                 3675             


Ala Leu  Cys Thr Ser Leu Val  Tyr Met Ile Ser Phe  Leu Pro Tyr 
    3680                 3685                 3690             


Ile Val  Leu Leu Val Leu His  Asn Gln Leu Ser Phe  Val Asn Gln 
    3695                 3700                 3705             


Thr Phe  Leu Cys Leu Leu Ser  Thr Thr Ala Phe Gly  Gln Gly Val 
    3710                 3715                 3720             


Phe Phe  Ile Thr Phe Leu Glu  Gly Gln Glu Thr Gly  Ile Gln Trp 
    3725                 3730                 3735             


Asn Asn  Met Tyr Gln Ala Leu  Glu Gln Gly Gly Met  Thr Phe Gly 
    3740                 3745                 3750             


Trp Val  Cys Trp Met Ile Leu  Phe Asp Ser Ser Leu  Tyr Phe Leu 
    3755                 3760                 3765             


Cys Gly  Trp Tyr Leu Ser Asn  Leu Ile Pro Gly Thr  Phe Gly Leu 
    3770                 3775                 3780             


Arg Lys  Pro Trp Tyr Phe Pro  Phe Thr Ala Ser Tyr  Trp Lys Ser 
    3785                 3790                 3795             


Val Gly  Phe Leu Val Glu Lys  Arg Gln Tyr Phe Leu  Ser Ser Ser 
    3800                 3805                 3810             


Leu Phe  Phe Phe Asn Glu Asn  Phe Asp Asn Lys Gly  Ser Ser Leu 
    3815                 3820                 3825             


Gln Asn  Arg Glu Gly Glu Leu  Glu Gly Ser Ala Pro  Gly Val Thr 
    3830                 3835                 3840             


Leu Val  Ser Val Thr Lys Glu  Tyr Glu Gly His Lys  Ala Val Val 
    3845                 3850                 3855             


Gln Asp  Leu Ser Leu Thr Phe  Tyr Arg Asp Gln Ile  Thr Ala Leu 
    3860                 3865                 3870             


Leu Gly  Thr Asn Gly Ala Gly  Lys Thr Thr Ile Ile  Ser Met Leu 
    3875                 3880                 3885             


Thr Gly  Leu His Pro Pro Thr  Ser Gly Thr Ile Ile  Ile Asn Gly 
    3890                 3895                 3900             


Lys Asn  Leu Gln Thr Asp Leu  Ser Arg Val Arg Met  Glu Leu Gly 
    3905                 3910                 3915             


Val Cys  Pro Gln Gln Asp Ile  Leu Leu Asp Asn Leu  Thr Val Arg 
    3920                 3925                 3930             


Glu His  Leu Leu Leu Phe Ala  Ser Ile Lys Ala Pro  Gln Trp Thr 
    3935                 3940                 3945             


Lys Lys  Glu Leu His Gln Gln  Val Asn Gln Thr Leu  Gln Asp Val 
    3950                 3955                 3960             


Asp Leu  Thr Gln His Gln His  Lys Gln Thr Arg Ala  Leu Ser Gly 
    3965                 3970                 3975             


Gly Leu  Lys Arg Lys Leu Ser  Leu Gly Ile Ala Phe  Met Gly Met 
    3980                 3985                 3990             


Ser Arg  Thr Val Val Leu Asp  Glu Pro Thr Ser Gly  Val Asp Pro 
    3995                 4000                 4005             


Cys Ser  Arg His Ser Leu Trp  Asp Ile Leu Leu Lys  Tyr Arg Glu 
    4010                 4015                 4020             


Gly Arg  Thr Ile Ile Phe Thr  Thr His His Leu Asp  Glu Ala Glu 
    4025                 4030                 4035             


Ala Leu  Ser Asp Arg Val Ala  Val Leu Gln His Gly  Arg Leu Arg 
    4040                 4045                 4050             


Cys Cys  Gly Pro Pro Phe Cys  Leu Lys Glu Ala Tyr  Gly Gln Gly 
    4055                 4060                 4065             


Leu Arg  Leu Thr Leu Thr Arg  Gln Pro Ser Val Leu  Glu Ala His 
    4070                 4075                 4080             


Asp Leu  Lys Asp Met Ala Cys  Val Thr Ser Leu Ile  Lys Ile Tyr 
    4085                 4090                 4095             


Ile Pro  Gln Ala Phe Leu Lys  Asp Ser Ser Gly Ser  Glu Leu Thr 
    4100                 4105                 4110             


Tyr Thr  Ile Pro Lys Asp Thr  Asp Lys Ala Cys Leu  Lys Gly Leu 
    4115                 4120                 4125             


Phe Gln  Ala Leu Asp Glu Asn  Leu His Gln Leu His  Leu Thr Gly 
    4130                 4135                 4140             


Tyr Gly  Ile Ser Asp Thr Thr  Leu Glu Glu Val Phe  Leu Met Leu 
    4145                 4150                 4155             


Leu Gln  Asp Ser Asn Lys Lys  Ser His Ile Ala Leu  Gly Thr Glu 
    4160                 4165                 4170             


Ser Glu  Leu Gln Asn His Arg  Pro Thr Gly His Leu  Ser Gly Tyr 
    4175                 4180                 4185             


Cys Gly  Ser Leu Ala Arg Pro  Ala Thr Val Gln Gly  Val Gln Leu 
    4190                 4195                 4200             


Leu Arg  Ala Gln Val Ala Ala  Ile Leu Ala Arg Arg  Leu Arg Arg 
    4205                 4210                 4215             


Thr Leu  Arg Ala Gly Lys Ser  Thr Leu Ala Asp Leu  Leu Leu Pro 
    4220                 4225                 4230             


Val Leu  Phe Val Ala Leu Ala  Met Gly Leu Phe Met  Val Arg Pro 
    4235                 4240                 4245             


Leu Ala  Thr Glu Tyr Pro Pro  Leu Arg Leu Thr Pro  Gly His Tyr 
    4250                 4255                 4260             


Gln Arg  Ala Glu Thr Tyr Phe  Phe Ser Ser Gly Gly  Asp Asn Leu 
    4265                 4270                 4275             


Asp Leu  Thr Arg Val Leu Leu  Arg Lys Phe Arg Asp  Gln Asp Leu 
    4280                 4285                 4290             


Pro Cys  Ala Asp Leu Asn Pro  Arg Gln Lys Asn Ser  Ser Cys Trp 
    4295                 4300                 4305             


Arg Thr  Asp Pro Phe Ser His  Pro Glu Phe Gln Asp  Ser Cys Gly 
    4310                 4315                 4320             


Cys Leu  Lys Cys Pro Asn Arg  Ser Ala Ser Ala Pro  Tyr Leu Thr 
    4325                 4330                 4335             


Asn His  Leu Gly His Thr Leu  Leu Asn Leu Ser Gly  Phe Asn Met 
    4340                 4345                 4350             


Glu Glu  Tyr Leu Leu Ala Pro  Ser Glu Lys Pro Arg  Leu Gly Gly 
    4355                 4360                 4365             


Trp Ser  Phe Gly Leu Lys Ile  Pro Ser Glu Ala Gly  Gly Ala Asn 
    4370                 4375                 4380             


Gly Asn  Ile Ser Lys Pro Pro  Thr Leu Ala Lys Val  Trp Tyr Asn 
    4385                 4390                 4395             


Gln Lys  Gly Phe His Ser Leu  Pro Ser Tyr Leu Asn  His Leu Asn 
    4400                 4405                 4410             


Asn Leu  Ile Leu Trp Gln His  Leu Pro Pro Thr Val  Asp Trp Arg 
    4415                 4420                 4425             


Gln Tyr  Gly Ile Thr Leu Tyr  Ser His Pro Tyr Gly  Gly Ala Leu 
    4430                 4435                 4440             


Leu Asn  Glu Asp Lys Ile Leu  Glu Ser Ile Arg Gln  Cys Gly Val 
    4445                 4450                 4455             


Ala Leu  Cys Ile Val Leu Gly  Phe Ser Ile Leu Ser  Ala Ser Ile 
    4460                 4465                 4470             


Gly Ser  Ser Val Val Arg Asp  Arg Val Ile Gly Ala  Lys Arg Leu 
    4475                 4480                 4485             


Gln His  Ile Ser Gly Leu Gly  Tyr Arg Met Tyr Trp  Phe Thr Asn 
    4490                 4495                 4500             


Phe Leu  Tyr Asp Met Leu Phe  Tyr Leu Val Ser Val  Cys Leu Cys 
    4505                 4510                 4515             


Val Ala  Val Ile Val Ala Phe  Gln Leu Thr Ala Phe  Thr Phe Arg 
    4520                 4525                 4530             


Lys Asn  Leu Ala Ala Thr Ala  Leu Leu Leu Ser Leu  Phe Gly Tyr 
    4535                 4540                 4545             


Ala Thr  Leu Pro Trp Met Tyr  Leu Met Ser Arg Ile  Phe Ser Ser 
    4550                 4555                 4560             


Ser Asp  Val Ala Phe Ile Ser  Tyr Val Ser Leu Asn  Phe Ile Phe 
    4565                 4570                 4575             


Gly Leu  Cys Thr Met Leu Ile  Thr Ile Met Pro Arg  Leu Leu Ala 
    4580                 4585                 4590             


Ile Ile  Ser Lys Ala Lys Asn  Leu Gln Asn Ile Tyr  Asp Val Leu 
    4595                 4600                 4605             


Lys Trp  Val Phe Thr Ile Phe  Pro Gln Phe Cys Leu  Gly Gln Gly 
    4610                 4615                 4620             


Leu Val  Glu Leu Cys Tyr Asn  Gln Ile Lys Tyr Asp  Leu Thr His 
    4625                 4630                 4635             


Asn Phe  Gly Ile Asp Ser Tyr  Val Ser Pro Phe Glu  Met Asn Phe 
    4640                 4645                 4650             


Leu Gly  Trp Ile Phe Val Gln  Leu Ala Ser Gln Gly  Thr Val Leu 
    4655                 4660                 4665             


Leu Leu  Leu Arg Val Leu Leu  His Trp Asp Leu Leu  Arg Trp Pro 
    4670                 4675                 4680             


Arg Gly  His Ser Thr Leu Gln  Gly Thr Val Lys Ser  Ser Lys Asp 
    4685                 4690                 4695             


Thr Asp  Val Glu Lys Glu Glu  Lys Arg Val Phe Glu  Gly Arg Thr 
    4700                 4705                 4710             


Asn Gly  Asp Ile Leu Val Leu  Tyr Asn Leu Ser Lys  His Tyr Arg 
    4715                 4720                 4725             


Arg Phe  Phe Gln Asn Ile Ile  Ala Val Gln Asp Ile  Ser Leu Gly 
    4730                 4735                 4740             


Ile Pro  Lys Gly Glu Cys Phe  Gly Leu Leu Gly Val  Asn Gly Ala 
    4745                 4750                 4755             


Gly Lys  Ser Thr Thr Phe Lys  Met Leu Asn Gly Glu  Val Ser Leu 
    4760                 4765                 4770             


Thr Ser  Gly His Ala Ile Ile  Arg Thr Pro Met Gly  Asp Ala Val 
    4775                 4780                 4785             


Asp Leu  Ser Ser Ala Gly Thr  Ala Gly Val Leu Ile  Gly Tyr Cys 
    4790                 4795                 4800             


Pro Gln  Gln Asp Ala Leu Asp  Glu Leu Leu Thr Gly  Trp Glu His 
    4805                 4810                 4815             


Leu Tyr  Tyr Tyr Cys Ser Leu  Arg Gly Ile Pro Arg  Gln Cys Ile 
    4820                 4825                 4830             


Pro Glu  Val Ala Gly Asp Leu  Ile Arg Arg Leu His  Leu Glu Ala 
    4835                 4840                 4845             


His Ala  Asp Lys Pro Val Ala  Thr Tyr Ser Gly Gly  Thr Lys Arg 
    4850                 4855                 4860             


Lys Leu  Ser Thr Ala Leu Ala  Leu Val Gly Lys Pro  Asp Ile Leu 
    4865                 4870                 4875             


Leu Leu  Asp Glu Pro Ser Ser  Gly Met Asp Pro Cys  Ser Lys Arg 
    4880                 4885                 4890             


Tyr Leu  Trp Gln Thr Ile Met  Lys Glu Val Arg Glu  Gly Cys Ala 
    4895                 4900                 4905             


Ala Val  Leu Thr Ser His Ser  Met Glu Glu Cys Glu  Ala Leu Cys 
    4910                 4915                 4920             


Thr Arg  Leu Ala Ile Met Val  Asn Gly Ser Phe Lys  Cys Leu Gly 
    4925                 4930                 4935             


Ser Pro  Gln His Ile Lys Asn  Arg Phe Gly Asp Gly  Tyr Thr Val 
    4940                 4945                 4950             


Lys Val  Trp Leu Cys Lys Glu  Ala Asn Gln His Cys  Thr Val Ser 
    4955                 4960                 4965             


Asp His  Leu Lys Leu Tyr Phe  Pro Gly Ile Gln Phe  Lys Gly Gln 
    4970                 4975                 4980             


His Leu  Asn Leu Leu Glu Tyr  His Val Pro Lys Arg  Trp Gly Cys 
    4985                 4990                 4995             


Leu Ala  Asp Leu Phe Lys Val  Ile Glu Asn Asn Lys  Thr Phe Leu 
    5000                 5005                 5010             


Asn Ile  Lys His Tyr Ser Ile  Asn Gln Thr Thr Leu  Glu Gln Val 
    5015                 5020                 5025             


Phe Ile  Asn Phe Ala Ser Glu  Gln Gln Gln Thr Leu  Gln Ser Thr 
    5030                 5035                 5040             


Leu Asp  Pro Ser Thr Asp Ser  His His Thr His His  Leu Pro Ile 
    5045                 5050                 5055             


<210>  131
<211>  249
<212>  PRT
<213>  homo sapiens

<400>  131

Met Glu Met Gly Arg Arg Ile His Leu Glu Leu Arg Asn Arg Thr Pro 
1               5                   10                  15      


Ser Asp Val Lys Glu Leu Val Leu Asp Asn Ser Arg Ser Asn Glu Gly 
            20                  25                  30          


Lys Leu Glu Gly Leu Thr Asp Glu Phe Glu Glu Leu Glu Phe Leu Ser 
        35                  40                  45              


Thr Ile Asn Val Gly Leu Thr Ser Ile Ala Asn Leu Pro Lys Leu Asn 
    50                  55                  60                  


Lys Leu Lys Lys Leu Glu Leu Ser Asp Asn Arg Val Ser Gly Gly Leu 
65                  70                  75                  80  


Glu Val Leu Ala Glu Lys Cys Pro Asn Leu Thr His Leu Asn Leu Ser 
                85                  90                  95      


Gly Asn Lys Ile Lys Asp Leu Ser Thr Ile Glu Pro Leu Lys Lys Leu 
            100                 105                 110         


Glu Asn Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu 
        115                 120                 125             


Asn Asp Tyr Arg Glu Asn Val Phe Lys Leu Leu Pro Gln Leu Thr Tyr 
    130                 135                 140                 


Leu Asp Gly Tyr Asp Arg Asp Asp Lys Glu Ala Pro Asp Ser Asp Ala 
145                 150                 155                 160 


Glu Gly Tyr Val Glu Gly Leu Asp Asp Glu Glu Glu Asp Glu Asp Glu 
                165                 170                 175     


Glu Glu Tyr Asp Glu Asp Ala Gln Val Val Glu Asp Glu Glu Asp Glu 
            180                 185                 190         


Asp Glu Glu Glu Glu Gly Glu Glu Glu Asp Val Ser Gly Glu Glu Glu 
        195                 200                 205             


Glu Asp Glu Glu Gly Tyr Asn Asp Gly Glu Val Asp Asp Glu Glu Asp 
    210                 215                 220                 


Glu Glu Glu Leu Gly Glu Glu Glu Arg Gly Gln Lys Arg Lys Arg Glu 
225                 230                 235                 240 


Pro Glu Asp Glu Gly Glu Asp Asp Asp 
                245                 


<210>  132
<211>  1124
<212>  PRT
<213>  homo sapiens

<400>  132

Met Asp Pro Phe Thr Glu Lys Leu Leu Glu Arg Thr Arg Ala Arg Arg 
1               5                   10                  15      


Glu Asn Leu Gln Arg Lys Met Ala Glu Arg Pro Thr Ala Ala Pro Arg 
            20                  25                  30          


Ser Met Thr His Ala Lys Arg Ala Arg Gln Pro Leu Ser Glu Ala Ser 
        35                  40                  45              


Asn Gln Gln Pro Leu Ser Gly Gly Glu Glu Lys Ser Cys Thr Lys Pro 
    50                  55                  60                  


Ser Pro Ser Lys Lys Arg Cys Ser Asp Asn Thr Glu Val Glu Val Ser 
65                  70                  75                  80  


Asn Leu Glu Asn Lys Gln Pro Val Glu Ser Thr Ser Ala Lys Ser Cys 
                85                  90                  95      


Ser Pro Ser Pro Val Ser Pro Gln Val Gln Pro Gln Ala Ala Asp Thr 
            100                 105                 110         


Ile Ser Asp Ser Val Ala Val Pro Ala Ser Leu Leu Gly Met Arg Arg 
        115                 120                 125             


Gly Leu Asn Ser Arg Leu Glu Ala Thr Ala Ala Ser Ser Val Lys Thr 
    130                 135                 140                 


Arg Met Gln Lys Leu Ala Glu Gln Arg Arg Arg Trp Asp Asn Asp Asp 
145                 150                 155                 160 


Met Thr Asp Asp Ile Pro Glu Ser Ser Leu Phe Ser Pro Met Pro Ser 
                165                 170                 175     


Glu Glu Lys Ala Ala Ser Pro Pro Arg Pro Leu Leu Ser Asn Ala Ser 
            180                 185                 190         


Ala Thr Pro Val Gly Arg Arg Gly Arg Leu Ala Asn Leu Ala Ala Thr 
        195                 200                 205             


Ile Cys Ser Trp Glu Asp Asp Val Asn His Ser Phe Ala Lys Gln Asn 
    210                 215                 220                 


Ser Val Gln Glu Gln Pro Gly Thr Ala Cys Leu Ser Lys Phe Ser Ser 
225                 230                 235                 240 


Ala Ser Gly Ala Ser Ala Arg Ile Asn Ser Ser Ser Val Lys Gln Glu 
                245                 250                 255     


Ala Thr Phe Cys Ser Gln Arg Asp Gly Asp Ala Ser Leu Asn Lys Ala 
            260                 265                 270         


Leu Ser Ser Ser Ala Asp Asp Ala Ser Leu Val Asn Ala Ser Ile Ser 
        275                 280                 285             


Ser Ser Val Lys Ala Thr Ser Pro Val Lys Ser Thr Thr Ser Ile Thr 
    290                 295                 300                 


Asp Ala Lys Ser Cys Glu Gly Gln Asn Pro Glu Leu Leu Pro Lys Thr 
305                 310                 315                 320 


Pro Ile Ser Pro Leu Lys Thr Gly Val Ser Lys Pro Ile Val Lys Ser 
                325                 330                 335     


Thr Leu Ser Gln Thr Val Pro Ser Lys Gly Glu Leu Ser Arg Glu Ile 
            340                 345                 350         


Cys Leu Gln Ser Gln Ser Lys Asp Lys Ser Thr Thr Pro Gly Gly Thr 
        355                 360                 365             


Gly Ile Lys Pro Phe Leu Glu Arg Phe Gly Glu Arg Cys Gln Glu His 
    370                 375                 380                 


Ser Lys Glu Ser Pro Ala Arg Ser Thr Pro His Arg Thr Pro Ile Ile 
385                 390                 395                 400 


Thr Pro Asn Thr Lys Ala Ile Gln Glu Arg Leu Phe Lys Gln Asp Thr 
                405                 410                 415     


Ser Ser Ser Thr Thr His Leu Ala Gln Gln Leu Lys Gln Glu Arg Gln 
            420                 425                 430         


Lys Glu Leu Ala Cys Leu Arg Gly Arg Phe Asp Lys Gly Asn Ile Trp 
        435                 440                 445             


Ser Ala Glu Lys Gly Gly Asn Ser Lys Ser Lys Gln Leu Glu Thr Lys 
    450                 455                 460                 


Gln Glu Thr His Cys Gln Ser Thr Pro Leu Lys Lys His Gln Gly Val 
465                 470                 475                 480 


Ser Lys Thr Gln Ser Leu Pro Val Thr Glu Lys Val Thr Glu Asn Gln 
                485                 490                 495     


Ile Pro Ala Lys Asn Ser Ser Thr Glu Pro Lys Gly Phe Thr Glu Cys 
            500                 505                 510         


Glu Met Thr Lys Ser Ser Pro Leu Lys Ile Thr Leu Phe Leu Glu Glu 
        515                 520                 525             


Asp Lys Ser Leu Lys Val Thr Ser Asp Pro Lys Val Glu Gln Lys Ile 
    530                 535                 540                 


Glu Val Ile Arg Glu Ile Glu Met Ser Val Asp Asp Asp Asp Ile Asn 
545                 550                 555                 560 


Ser Ser Lys Val Ile Asn Asp Leu Phe Ser Asp Val Leu Glu Glu Gly 
                565                 570                 575     


Glu Leu Asp Met Glu Lys Ser Gln Glu Glu Met Asp Gln Ala Leu Ala 
            580                 585                 590         


Glu Ser Ser Glu Glu Gln Glu Asp Ala Leu Asn Ile Ser Ser Met Ser 
        595                 600                 605             


Leu Leu Ala Pro Leu Ala Gln Thr Val Gly Val Val Ser Pro Glu Ser 
    610                 615                 620                 


Leu Val Ser Thr Pro Arg Leu Glu Leu Lys Asp Thr Ser Arg Ser Asp 
625                 630                 635                 640 


Glu Ser Pro Lys Pro Gly Lys Phe Gln Arg Thr Arg Val Pro Arg Ala 
                645                 650                 655     


Glu Ser Gly Asp Ser Leu Gly Ser Glu Asp Arg Asp Leu Leu Tyr Ser 
            660                 665                 670         


Ile Asp Ala Tyr Arg Ser Gln Arg Phe Lys Glu Thr Glu Arg Pro Ser 
        675                 680                 685             


Ile Lys Gln Val Ile Val Arg Lys Glu Asp Val Thr Ser Lys Leu Asp 
    690                 695                 700                 


Glu Lys Asn Asn Ala Phe Pro Cys Gln Val Asn Ile Lys Gln Lys Met 
705                 710                 715                 720 


Gln Glu Leu Asn Asn Glu Ile Asn Met Gln Gln Thr Val Ile Tyr Gln 
                725                 730                 735     


Ala Ser Gln Ala Leu Asn Cys Cys Val Asp Glu Glu His Gly Lys Gly 
            740                 745                 750         


Ser Leu Glu Glu Ala Glu Ala Glu Arg Leu Leu Leu Ile Ala Thr Gly 
        755                 760                 765             


Lys Arg Thr Leu Leu Ile Asp Glu Leu Asn Lys Leu Lys Asn Glu Gly 
    770                 775                 780                 


Pro Gln Arg Lys Asn Lys Ala Ser Pro Gln Ser Glu Phe Met Pro Ser 
785                 790                 795                 800 


Lys Gly Ser Val Thr Leu Ser Glu Ile Arg Leu Pro Leu Lys Ala Asp 
                805                 810                 815     


Phe Val Cys Ser Thr Val Gln Lys Pro Asp Ala Ala Asn Tyr Tyr Tyr 
            820                 825                 830         


Leu Ile Ile Leu Lys Ala Gly Ala Glu Asn Met Val Ala Thr Pro Leu 
        835                 840                 845             


Ala Ser Thr Ser Asn Ser Leu Asn Gly Asp Ala Leu Thr Phe Thr Thr 
    850                 855                 860                 


Thr Phe Thr Leu Gln Asp Val Ser Asn Asp Phe Glu Ile Asn Ile Glu 
865                 870                 875                 880 


Val Tyr Ser Leu Val Gln Lys Lys Asp Pro Ser Gly Leu Asp Lys Lys 
                885                 890                 895     


Lys Lys Thr Ser Lys Ser Lys Ala Ile Thr Pro Lys Arg Leu Leu Thr 
            900                 905                 910         


Ser Ile Thr Thr Lys Ser Asn Ile His Ser Ser Val Met Ala Ser Pro 
        915                 920                 925             


Gly Gly Leu Ser Ala Val Arg Thr Ser Asn Phe Ala Leu Val Gly Ser 
    930                 935                 940                 


Tyr Thr Leu Ser Leu Ser Ser Val Gly Asn Thr Lys Phe Val Leu Asp 
945                 950                 955                 960 


Lys Val Pro Phe Leu Ser Ser Leu Glu Gly His Ile Tyr Leu Lys Ile 
                965                 970                 975     


Lys Cys Gln Val Asn Ser Ser Val Glu Glu Arg Gly Phe Leu Thr Ile 
            980                 985                 990         


Phe Glu Asp Val Ser Gly Phe Gly  Ala Trp His Arg Arg  Trp Cys Val 
        995                 1000                 1005             


Leu Ser  Gly Asn Cys Ile Ser  Tyr Trp Thr Tyr Pro  Asp Asp Glu 
    1010                 1015                 1020             


Lys Arg  Lys Asn Pro Ile Gly  Arg Ile Asn Leu Ala  Asn Cys Thr 
    1025                 1030                 1035             


Ser Arg  Gln Ile Glu Pro Ala  Asn Arg Glu Phe Cys  Ala Arg Arg 
    1040                 1045                 1050             


Asn Thr  Phe Glu Leu Ile Thr  Val Arg Pro Gln Arg  Glu Asp Asp 
    1055                 1060                 1065             


Arg Glu  Thr Leu Val Ser Gln  Cys Arg Asp Thr Leu  Cys Val Thr 
    1070                 1075                 1080             


Lys Asn  Trp Leu Ser Ala Asp  Thr Lys Glu Glu Arg  Asp Leu Trp 
    1085                 1090                 1095             


Met Gln  Lys Leu Asn Gln Val  Leu Val Asp Ile Arg  Leu Trp Gln 
    1100                 1105                 1110             


Pro Asp  Ala Cys Tyr Lys Pro  Ile Gly Lys Pro 
    1115                 1120                 


<210>  133
<211>  859
<212>  PRT
<213>  homo sapiens

<400>  133

Met Glu Pro Leu Ser His Arg Gly Leu Pro Arg Leu Ser Trp Ile Asp 
1               5                   10                  15      


Thr Leu Tyr Ser Asn Phe Ser Tyr Gly Thr Asp Glu Tyr Asp Gly Glu 
            20                  25                  30          


Gly Asn Glu Glu Gln Lys Gly Pro Pro Glu Gly Ser Glu Thr Met Pro 
        35                  40                  45              


Tyr Ile Asp Glu Ser Pro Thr Met Ser Pro Gln Leu Ser Ala Arg Ser 
    50                  55                  60                  


Gln Gly Arg Gly Asp Gly Val Ser Pro Thr Pro Pro Glu Gly Leu Ala 
65                  70                  75                  80  


Pro Gly Val Glu Ala Gly Lys Gly Leu Glu Met Arg Lys Leu Val Leu 
                85                  90                  95      


Ser Gly Phe Leu Ala Ser Glu Glu Ile Tyr Ile Asn Gln Leu Glu Ala 
            100                 105                 110         


Leu Leu Leu Pro Met Lys Pro Leu Lys Ala Thr Ala Thr Thr Ser Gln 
        115                 120                 125             


Pro Val Leu Thr Ile Gln Gln Ile Glu Thr Ile Phe Tyr Lys Ile Gln 
    130                 135                 140                 


Asp Ile Tyr Glu Ile His Lys Glu Phe Tyr Asp Asn Leu Cys Pro Lys 
145                 150                 155                 160 


Val Gln Gln Trp Asp Ser Gln Val Thr Met Gly His Leu Phe Gln Lys 
                165                 170                 175     


Leu Ala Ser Gln Leu Gly Val Tyr Lys Ala Phe Val Asp Asn Tyr Lys 
            180                 185                 190         


Val Ala Leu Glu Thr Ala Glu Lys Cys Ser Gln Ser Asn Asn Gln Phe 
        195                 200                 205             


Gln Lys Ile Ser Glu Glu Leu Lys Val Lys Gly Pro Lys Asp Ser Lys 
    210                 215                 220                 


Asp Ser His Thr Ser Val Thr Met Glu Ala Leu Leu Tyr Lys Pro Ile 
225                 230                 235                 240 


Asp Arg Val Thr Arg Ser Thr Leu Val Leu His Asp Leu Leu Lys His 
                245                 250                 255     


Thr Pro Val Asp His Pro Asp Tyr Pro Leu Leu Gln Asp Ala Leu Arg 
            260                 265                 270         


Ile Ser Gln Asn Phe Leu Ser Ser Ile Asn Glu Asp Ile Asp Pro Arg 
        275                 280                 285             


Arg Thr Ala Val Thr Thr Pro Lys Gly Glu Thr Arg Gln Leu Val Lys 
    290                 295                 300                 


Asp Gly Phe Leu Val Glu Val Ser Glu Ser Ser Arg Lys Leu Arg His 
305                 310                 315                 320 


Val Phe Leu Phe Thr Asp Val Leu Leu Cys Ala Lys Leu Lys Lys Thr 
                325                 330                 335     


Ser Ala Gly Lys His Gln Gln Tyr Asp Cys Lys Trp Tyr Ile Pro Leu 
            340                 345                 350         


Ala Asp Leu Val Phe Pro Ser Pro Glu Glu Ser Glu Ala Ser Pro Gln 
        355                 360                 365             


Val His Pro Phe Pro Asp His Glu Leu Glu Asp Met Lys Met Lys Ile 
    370                 375                 380                 


Ser Ala Leu Lys Ser Glu Ile Gln Lys Glu Lys Ala Asn Lys Gly Gln 
385                 390                 395                 400 


Ser Arg Ala Ile Glu Arg Leu Lys Lys Lys Met Phe Glu Asn Glu Phe 
                405                 410                 415     


Leu Leu Leu Leu Asn Ser Pro Thr Ile Pro Phe Arg Ile His Asn Arg 
            420                 425                 430         


Asn Gly Lys Ser Tyr Leu Phe Leu Leu Ser Ser Asp Tyr Glu Arg Ser 
        435                 440                 445             


Glu Trp Arg Glu Ala Ile Gln Lys Leu Gln Lys Lys Asp Leu Gln Ala 
    450                 455                 460                 


Phe Val Leu Ser Ser Val Glu Leu Gln Val Leu Thr Gly Ser Cys Phe 
465                 470                 475                 480 


Lys Leu Arg Thr Val His Asn Ile Pro Val Thr Ser Asn Lys Asp Asp 
                485                 490                 495     


Asp Glu Ser Pro Gly Leu Tyr Gly Phe Leu His Val Ile Val His Ser 
            500                 505                 510         


Ala Lys Gly Phe Lys Gln Ser Ala Asn Leu Tyr Cys Thr Leu Glu Val 
        515                 520                 525             


Asp Ser Phe Gly Tyr Phe Val Ser Lys Ala Lys Thr Arg Val Phe Arg 
    530                 535                 540                 


Asp Thr Ala Glu Pro Lys Trp Asp Glu Glu Phe Glu Ile Glu Leu Glu 
545                 550                 555                 560 


Gly Ser Gln Ser Leu Arg Ile Leu Cys Tyr Glu Lys Cys Tyr Asp Lys 
                565                 570                 575     


Thr Lys Val Asn Lys Asp Asn Asn Glu Ile Val Asp Lys Ile Met Gly 
            580                 585                 590         


Lys Gly Gln Ile Gln Leu Asp Pro Gln Thr Val Glu Thr Lys Asn Trp 
        595                 600                 605             


His Thr Asp Val Ile Glu Met Asn Gly Ile Lys Val Glu Phe Ser Met 
    610                 615                 620                 


Lys Phe Thr Ser Arg Asp Met Ser Leu Lys Arg Thr Pro Ser Lys Lys 
625                 630                 635                 640 


Gln Thr Gly Val Phe Gly Val Lys Ile Ser Val Val Thr Lys Arg Glu 
                645                 650                 655     


Arg Ser Lys Val Pro Tyr Ile Val Arg Gln Cys Val Glu Glu Val Glu 
            660                 665                 670         


Lys Arg Gly Ile Glu Glu Val Gly Ile Tyr Arg Ile Ser Gly Val Ala 
        675                 680                 685             


Thr Asp Ile Gln Ala Leu Lys Ala Val Phe Asp Ala Asn Asn Lys Asp 
    690                 695                 700                 


Ile Leu Leu Met Leu Ser Asp Met Asp Ile Asn Ala Ile Ala Gly Thr 
705                 710                 715                 720 


Leu Lys Leu Tyr Phe Arg Glu Leu Pro Glu Pro Leu Leu Thr Asp Arg 
                725                 730                 735     


Leu Tyr Pro Ala Phe Met Glu Gly Ile Ala Leu Ser Asp Pro Ala Ala 
            740                 745                 750         


Lys Glu Asn Cys Met Met His Leu Leu Arg Ser Leu Pro Asp Pro Asn 
        755                 760                 765             


Leu Ile Thr Phe Leu Phe Leu Leu Glu His Leu Lys Arg Val Ala Glu 
    770                 775                 780                 


Lys Glu Pro Ile Asn Lys Met Ser Leu His Asn Leu Ala Thr Val Phe 
785                 790                 795                 800 


Gly Pro Thr Leu Leu Arg Pro Ser Glu Val Glu Ser Lys Ala His Leu 
                805                 810                 815     


Thr Ser Ala Ala Asp Ile Trp Ser His Asp Val Met Ala Gln Val Gln 
            820                 825                 830         


Val Leu Leu Tyr Tyr Leu Gln His Pro Pro Ile Ser Phe Ala Glu Leu 
        835                 840                 845             


Lys Arg Asn Thr Leu Tyr Phe Ser Thr Asp Val 
    850                 855                 


<210>  134
<211>  513
<212>  PRT
<213>  homo sapiens

<400>  134

Met Gly Ala Ala Ala Lys Leu Ala Phe Ala Val Phe Leu Ile Ser Cys 
1               5                   10                  15      


Ser Ser Gly Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe 
            20                  25                  30          


Phe Asn Ala Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu 
        35                  40                  45              


Pro Cys Tyr Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp 
    50                  55                  60                  


Lys Asn Ile Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu 
65                  70                  75                  80  


Asp Asp Ile Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp 
                85                  90                  95      


Ser Pro Glu Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu 
            100                 105                 110         


Lys Phe Ser Tyr Phe Pro Glu Met Glu Val Thr Gln Pro Thr Ser Asn 
        115                 120                 125             


Pro Val Thr Pro Lys Pro Pro Tyr Tyr Asn Ile Leu Leu Tyr Ser Leu 
    130                 135                 140                 


Val Pro Leu Met Leu Ile Ala Gly Ile Val Ile Cys Ala Phe Trp Val 
145                 150                 155                 160 


Tyr Arg His His Lys Met Ala Tyr Pro Pro Val Leu Val Pro Thr Gln 
                165                 170                 175     


Asp Pro Gly Pro Pro Pro Pro Ser Pro Leu Leu Gly Leu Lys Pro Leu 
            180                 185                 190         


Gln Leu Leu Glu Val Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys 
        195                 200                 205             


Ala Gln Leu Leu Asn Glu Tyr Val Ala Val Lys Ile Phe Pro Ile Gln 
    210                 215                 220                 


Asp Lys Gln Ser Trp Gln Asn Glu Tyr Glu Val Tyr Ser Leu Pro Gly 
225                 230                 235                 240 


Met Lys His Glu Asn Ile Leu Gln Phe Ile Gly Ala Glu Lys Arg Gly 
                245                 250                 255     


Thr Ser Val Asp Val Asp Leu Trp Leu Ile Thr Ala Phe His Glu Lys 
            260                 265                 270         


Gly Ser Leu Ser Asp Phe Leu Lys Ala Asn Val Val Ser Trp Asn Glu 
        275                 280                 285             


Leu Cys His Ile Ala Glu Thr Met Ala Arg Gly Leu Ala Tyr Leu His 
    290                 295                 300                 


Glu Asp Ile Pro Gly Leu Lys Asp Gly His Lys Pro Ala Ile Ser His 
305                 310                 315                 320 


Arg Asp Ile Lys Ser Lys Asn Val Leu Leu Lys Asn Asn Leu Thr Ala 
                325                 330                 335     


Cys Ile Ala Asp Phe Gly Leu Ala Leu Lys Phe Glu Ala Gly Lys Ser 
            340                 345                 350         


Ala Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro 
        355                 360                 365             


Glu Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg 
    370                 375                 380                 


Ile Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Ala Ser Arg 
385                 390                 395                 400 


Cys Thr Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu 
                405                 410                 415     


Glu Glu Ile Gly Gln His Pro Ser Leu Glu Asp Met Gln Glu Val Val 
            420                 425                 430         


Val His Lys Lys Lys Arg Pro Val Leu Arg Asp Tyr Trp Gln Lys His 
        435                 440                 445             


Ala Gly Met Ala Met Leu Cys Glu Thr Ile Glu Glu Cys Trp Asp His 
    450                 455                 460                 


Asp Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Gly Glu Arg Ile Thr 
465                 470                 475                 480 


Gln Met Gln Arg Leu Thr Asn Ile Ile Thr Thr Glu Asp Ile Val Thr 
                485                 490                 495     


Val Val Thr Met Val Thr Asn Val Asp Phe Pro Pro Lys Glu Ser Ser 
            500                 505                 510         


Leu 
    


<210>  135
<211>  1124
<212>  PRT
<213>  homo sapiens

<400>  135

Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu 
1               5                   10                  15      


Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu 
            20                  25                  30          


Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly 
        35                  40                  45              


Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu 
    50                  55                  60                  


Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg 
65                  70                  75                  80  


Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile 
                85                  90                  95      


Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg 
            100                 105                 110         


Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr 
        115                 120                 125             


Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys 
    130                 135                 140                 


Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser 
145                 150                 155                 160 


Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val 
                165                 170                 175     


His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg 
            180                 185                 190         


Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val 
        195                 200                 205             


Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys 
    210                 215                 220                 


Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys 
225                 230                 235                 240 


Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu 
                245                 250                 255     


Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu 
            260                 265                 270         


Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser 
        275                 280                 285             


Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro 
    290                 295                 300                 


Gly Phe Tyr Gly Pro Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly 
305                 310                 315                 320 


Glu Met Cys Asp Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln 
                325                 330                 335     


Gly Leu Gln Cys Glu Arg Glu Gly Ile Pro Arg Met Thr Pro Lys Ile 
            340                 345                 350         


Val Asp Leu Pro Asp His Ile Glu Val Asn Ser Gly Lys Phe Asn Pro 
        355                 360                 365             


Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr Asn Glu Glu Met Thr 
    370                 375                 380                 


Leu Val Lys Pro Asp Gly Thr Val Leu His Pro Lys Asp Phe Asn His 
385                 390                 395                 400 


Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile His Arg Ile Leu Pro 
                405                 410                 415     


Pro Asp Ser Gly Val Trp Val Cys Ser Val Asn Thr Val Ala Gly Met 
            420                 425                 430         


Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val Leu Pro Lys Pro Leu 
        435                 440                 445             


Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn Phe Ala Val Ile Asn 
    450                 455                 460                 


Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro Ile Lys Ser Lys Lys 
465                 470                 475                 480 


Leu Leu Tyr Lys Pro Val Asn His Tyr Glu Ala Trp Gln His Ile Gln 
                485                 490                 495     


Val Thr Asn Glu Ile Val Thr Leu Asn Tyr Leu Glu Pro Arg Thr Glu 
            500                 505                 510         


Tyr Glu Leu Cys Val Gln Leu Val Arg Arg Gly Glu Gly Gly Glu Gly 
        515                 520                 525             


His Pro Gly Pro Val Arg Arg Phe Thr Thr Ala Ser Ile Gly Leu Pro 
    530                 535                 540                 


Pro Pro Arg Gly Leu Asn Leu Leu Pro Lys Ser Gln Thr Thr Leu Asn 
545                 550                 555                 560 


Leu Thr Trp Gln Pro Ile Phe Pro Ser Ser Glu Asp Asp Phe Tyr Val 
                565                 570                 575     


Glu Val Glu Arg Arg Ser Val Gln Lys Ser Asp Gln Gln Asn Ile Lys 
            580                 585                 590         


Val Pro Gly Asn Leu Thr Ser Val Leu Leu Asn Asn Leu His Pro Arg 
        595                 600                 605             


Glu Gln Tyr Val Val Arg Ala Arg Val Asn Thr Lys Ala Gln Gly Glu 
    610                 615                 620                 


Trp Ser Glu Asp Leu Thr Ala Trp Thr Leu Ser Asp Ile Leu Pro Pro 
625                 630                 635                 640 


Gln Pro Glu Asn Ile Lys Ile Ser Asn Ile Thr His Ser Ser Ala Val 
                645                 650                 655     


Ile Ser Trp Thr Ile Leu Asp Gly Tyr Ser Ile Ser Ser Ile Thr Ile 
            660                 665                 670         


Arg Tyr Lys Val Gln Gly Lys Asn Glu Asp Gln His Val Asp Val Lys 
        675                 680                 685             


Ile Lys Asn Ala Thr Ile Ile Gln Tyr Gln Leu Lys Gly Leu Glu Pro 
    690                 695                 700                 


Glu Thr Ala Tyr Gln Val Asp Ile Phe Ala Glu Asn Asn Ile Gly Ser 
705                 710                 715                 720 


Ser Asn Pro Ala Phe Ser His Glu Leu Val Thr Leu Pro Glu Ser Gln 
                725                 730                 735     


Ala Pro Ala Asp Leu Gly Gly Gly Lys Met Leu Leu Ile Ala Ile Leu 
            740                 745                 750         


Gly Ser Ala Gly Met Thr Cys Leu Thr Val Leu Leu Ala Phe Leu Ile 
        755                 760                 765             


Ile Leu Gln Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala 
    770                 775                 780                 


Phe Gln Asn Val Arg Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr 
785                 790                 795                 800 


Leu Ala Leu Asn Arg Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr 
                805                 810                 815     


Pro Val Leu Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu 
            820                 825                 830         


Gly Asn Phe Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu 
        835                 840                 845             


Arg Met Asp Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp 
    850                 855                 860                 


Asp His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly 
865                 870                 875                 880 


His His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Glu His Arg Gly 
                885                 890                 895     


Tyr Leu Tyr Leu Ala Ile Glu Tyr Ala Pro His Gly Asn Leu Leu Asp 
            900                 905                 910         


Phe Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Ile 
        915                 920                 925             


Ala Asn Ser Thr Ala Ser Thr Leu Ser Ser Gln Gln Leu Leu His Phe 
    930                 935                 940                 


Ala Ala Asp Val Ala Arg Gly Met Asp Tyr Leu Ser Gln Lys Gln Phe 
945                 950                 955                 960 


Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Tyr 
                965                 970                 975     


Val Ala Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Gln Glu Val Tyr 
            980                 985                 990         


Val Lys Lys Thr Met Gly Arg Leu  Pro Val Arg Trp Met  Ala Ile Glu 
        995                 1000                 1005             


Ser Leu  Asn Tyr Ser Val Tyr  Thr Thr Asn Ser Asp  Val Trp Ser 
    1010                 1015                 1020             


Tyr Gly  Val Leu Leu Trp Glu  Ile Val Ser Leu Gly  Gly Thr Pro 
    1025                 1030                 1035             


Tyr Cys  Gly Met Thr Cys Ala  Glu Leu Tyr Glu Lys  Leu Pro Gln 
    1040                 1045                 1050             


Gly Tyr  Arg Leu Glu Lys Pro  Leu Asn Cys Asp Asp  Glu Val Tyr 
    1055                 1060                 1065             


Asp Leu  Met Arg Gln Cys Trp  Arg Glu Lys Pro Tyr  Glu Arg Pro 
    1070                 1075                 1080             


Ser Phe  Ala Gln Ile Leu Val  Ser Leu Asn Arg Met  Leu Glu Glu 
    1085                 1090                 1095             


Arg Lys  Thr Tyr Val Asn Thr  Thr Leu Tyr Glu Lys  Phe Thr Tyr 
    1100                 1105                 1110             


Ala Gly  Ile Asp Cys Ser Ala  Glu Glu Ala Ala 
    1115                 1120                 


<210>  136
<211>  323
<212>  PRT
<213>  homo sapiens

<400>  136

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp 
            


<210>  137
<211>  529
<212>  PRT
<213>  homo sapiens

<400>  137

Met Leu Gly Phe Val Gly Arg Val Ala Ala Ala Pro Ala Ser Gly Ala 
1               5                   10                  15      


Leu Arg Arg Leu Thr Pro Ser Ala Ser Leu Pro Pro Ala Gln Leu Leu 
            20                  25                  30          


Leu Arg Ala Ala Pro Thr Ala Val His Pro Val Arg Asp Tyr Ala Ala 
        35                  40                  45              


Gln Thr Ser Pro Ser Pro Lys Ala Gly Ala Ala Thr Gly Arg Ile Val 
    50                  55                  60                  


Ala Val Ile Gly Ala Val Val Asp Val Gln Phe Asp Glu Gly Leu Pro 
65                  70                  75                  80  


Pro Ile Leu Asn Ala Leu Glu Val Gln Gly Arg Glu Thr Arg Leu Val 
                85                  90                  95      


Leu Glu Val Ala Gln His Leu Gly Glu Ser Thr Val Arg Thr Ile Ala 
            100                 105                 110         


Met Asp Gly Thr Glu Gly Leu Val Arg Gly Gln Lys Val Leu Asp Ser 
        115                 120                 125             


Gly Ala Pro Ile Lys Ile Pro Val Gly Pro Glu Thr Leu Gly Arg Ile 
    130                 135                 140                 


Met Asn Val Ile Gly Glu Pro Ile Asp Glu Arg Gly Pro Ile Lys Thr 
145                 150                 155                 160 


Lys Gln Phe Ala Pro Ile His Ala Glu Ala Pro Glu Phe Met Glu Met 
                165                 170                 175     


Ser Val Glu Gln Glu Ile Leu Val Thr Gly Ile Lys Val Val Asp Leu 
            180                 185                 190         


Leu Ala Pro Tyr Ala Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala 
        195                 200                 205             


Gly Val Gly Lys Thr Val Leu Ile Met Glu Leu Ile Asn Asn Val Ala 
    210                 215                 220                 


Lys Ala His Gly Gly Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr 
225                 230                 235                 240 


Arg Glu Gly Asn Asp Leu Tyr His Glu Met Ile Glu Ser Gly Val Ile 
                245                 250                 255     


Asn Leu Lys Asp Ala Thr Ser Lys Val Ala Leu Val Tyr Gly Gln Met 
            260                 265                 270         


Asn Glu Pro Pro Gly Ala Arg Ala Arg Val Ala Leu Thr Gly Leu Thr 
        275                 280                 285             


Val Ala Glu Tyr Phe Arg Asp Gln Glu Gly Gln Asp Val Leu Leu Phe 
    290                 295                 300                 


Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly Ser Glu Val Ser Ala 
305                 310                 315                 320 


Leu Leu Gly Arg Ile Pro Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala 
                325                 330                 335     


Thr Asp Met Gly Thr Met Gln Glu Arg Ile Thr Thr Thr Lys Lys Gly 
            340                 345                 350         


Ser Ile Thr Ser Val Gln Ala Ile Tyr Val Pro Ala Asp Asp Leu Thr 
        355                 360                 365             


Asp Pro Ala Pro Ala Thr Thr Phe Ala His Leu Asp Ala Thr Thr Val 
    370                 375                 380                 


Leu Ser Arg Ala Ile Ala Glu Leu Gly Ile Tyr Pro Ala Val Asp Pro 
385                 390                 395                 400 


Leu Asp Ser Thr Ser Arg Ile Met Asp Pro Asn Ile Val Gly Ser Glu 
                405                 410                 415     


His Tyr Asp Val Ala Arg Gly Val Gln Lys Ile Leu Gln Asp Tyr Lys 
            420                 425                 430         


Ser Leu Gln Asp Ile Ile Ala Ile Leu Gly Met Asp Glu Leu Ser Glu 
        435                 440                 445             


Glu Asp Lys Leu Thr Val Ser Arg Ala Arg Lys Ile Gln Arg Phe Leu 
    450                 455                 460                 


Ser Gln Pro Phe Gln Val Ala Glu Val Phe Thr Gly His Met Gly Lys 
465                 470                 475                 480 


Leu Val Pro Leu Lys Glu Thr Ile Lys Gly Phe Gln Gln Ile Leu Ala 
                485                 490                 495     


Gly Glu Tyr Asp His Leu Pro Glu Gln Ala Phe Tyr Met Val Gly Pro 
            500                 505                 510         


Ile Glu Glu Ala Val Ala Lys Ala Asp Lys Leu Ala Glu Glu His Ser 
        515                 520                 525             


Ser 
    


<210>  138
<211>  1624
<212>  PRT
<213>  homo sapiens

<400>  138

Met Ser Lys Arg Arg Met Ser Val Gly Gln Gln Thr Trp Ala Leu Leu 
1               5                   10                  15      


Cys Lys Asn Cys Leu Lys Lys Trp Arg Met Lys Arg Gln Thr Leu Leu 
            20                  25                  30          


Glu Trp Leu Phe Ser Phe Leu Leu Val Leu Phe Leu Tyr Leu Phe Phe 
        35                  40                  45              


Ser Asn Leu His Gln Val His Asp Thr Pro Gln Met Ser Ser Met Asp 
    50                  55                  60                  


Leu Gly Arg Val Asp Ser Phe Asn Asp Thr Asn Tyr Val Ile Ala Phe 
65                  70                  75                  80  


Ala Pro Glu Ser Lys Thr Thr Gln Glu Ile Met Asn Lys Val Ala Ser 
                85                  90                  95      


Ala Pro Phe Leu Lys Gly Arg Thr Ile Met Gly Trp Pro Asp Glu Lys 
            100                 105                 110         


Ser Met Asp Glu Leu Asp Leu Asn Tyr Ser Ile Asp Ala Val Arg Val 
        115                 120                 125             


Ile Phe Thr Asp Thr Phe Ser Tyr His Leu Lys Phe Ser Trp Gly His 
    130                 135                 140                 


Arg Ile Pro Met Met Lys Glu His Arg Asp His Ser Ala His Cys Gln 
145                 150                 155                 160 


Ala Val Asn Glu Lys Met Lys Cys Glu Gly Ser Glu Phe Trp Glu Lys 
                165                 170                 175     


Gly Phe Val Ala Phe Gln Ala Ala Ile Asn Ala Ala Ile Ile Glu Ile 
            180                 185                 190         


Ala Thr Asn His Ser Val Met Glu Gln Leu Met Ser Val Thr Gly Val 
        195                 200                 205             


His Met Lys Ile Leu Pro Phe Val Ala Gln Gly Gly Val Ala Thr Asp 
    210                 215                 220                 


Phe Phe Ile Phe Phe Cys Ile Ile Ser Phe Ser Thr Phe Ile Tyr Tyr 
225                 230                 235                 240 


Val Ser Val Asn Val Thr Gln Glu Arg Gln Tyr Ile Thr Ser Leu Met 
                245                 250                 255     


Thr Met Met Gly Leu Arg Glu Ser Ala Phe Trp Leu Ser Trp Gly Leu 
            260                 265                 270         


Met Tyr Ala Gly Phe Ile Leu Ile Met Ala Thr Leu Met Ala Leu Ile 
        275                 280                 285             


Val Lys Ser Ala Gln Ile Val Val Leu Thr Gly Phe Val Met Val Phe 
    290                 295                 300                 


Thr Leu Phe Leu Leu Tyr Gly Leu Ser Leu Ile Thr Leu Ala Phe Leu 
305                 310                 315                 320 


Met Ser Val Leu Ile Lys Lys Pro Phe Leu Thr Gly Leu Val Val Phe 
                325                 330                 335     


Leu Leu Ile Val Phe Trp Gly Ile Leu Gly Phe Pro Ala Leu Tyr Thr 
            340                 345                 350         


Arg Leu Pro Ala Phe Leu Glu Trp Thr Leu Cys Leu Leu Ser Pro Phe 
        355                 360                 365             


Ala Phe Thr Val Gly Met Ala Gln Leu Ile His Leu Asp Tyr Asp Val 
    370                 375                 380                 


Asn Ser Asn Ala His Leu Asp Ser Ser Gln Asn Pro Tyr Leu Ile Ile 
385                 390                 395                 400 


Ala Thr Leu Phe Met Leu Val Phe Asp Thr Leu Leu Tyr Leu Val Leu 
                405                 410                 415     


Thr Leu Tyr Phe Asp Lys Ile Leu Pro Ala Glu Tyr Gly His Arg Cys 
            420                 425                 430         


Ser Pro Leu Phe Phe Leu Lys Ser Cys Phe Trp Phe Gln His Gly Arg 
        435                 440                 445             


Ala Asn His Val Val Leu Glu Asn Glu Thr Asp Ser Asp Pro Thr Pro 
    450                 455                 460                 


Asn Asp Cys Phe Glu Pro Val Ser Pro Glu Phe Cys Gly Lys Glu Ala 
465                 470                 475                 480 


Ile Arg Ile Lys Asn Leu Lys Lys Glu Tyr Ala Gly Lys Cys Glu Arg 
                485                 490                 495     


Val Glu Ala Leu Lys Gly Val Val Phe Asp Ile Tyr Glu Gly Gln Ile 
            500                 505                 510         


Thr Ala Leu Leu Gly His Ser Gly Ala Gly Lys Thr Thr Leu Leu Asn 
        515                 520                 525             


Ile Leu Ser Gly Leu Ser Val Pro Thr Ser Gly Ser Val Thr Val Tyr 
    530                 535                 540                 


Asn His Thr Leu Ser Arg Met Ala Asp Ile Glu Asn Ile Ser Lys Phe 
545                 550                 555                 560 


Thr Gly Phe Cys Pro Gln Ser Asn Val Gln Phe Gly Phe Leu Thr Val 
                565                 570                 575     


Lys Glu Asn Leu Arg Leu Phe Ala Lys Ile Lys Gly Ile Leu Pro His 
            580                 585                 590         


Glu Val Glu Lys Glu Val Gln Arg Val Val Gln Glu Leu Glu Met Glu 
        595                 600                 605             


Asn Ile Gln Asp Ile Leu Ala Gln Asn Leu Ser Gly Gly Gln Asn Arg 
    610                 615                 620                 


Lys Leu Thr Phe Gly Ile Ala Ile Leu Gly Asp Pro Gln Val Leu Leu 
625                 630                 635                 640 


Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Leu Ser Arg His Arg Ile 
                645                 650                 655     


Trp Asn Leu Leu Lys Glu Gly Lys Ser Asp Arg Val Ile Leu Phe Ser 
            660                 665                 670         


Thr Gln Phe Ile Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Val Phe 
        675                 680                 685             


Ile Ser Asn Gly Lys Leu Lys Cys Ala Gly Ser Ser Leu Phe Leu Lys 
    690                 695                 700                 


Lys Lys Trp Gly Ile Gly Tyr His Leu Ser Leu His Leu Asn Glu Arg 
705                 710                 715                 720 


Cys Asp Pro Glu Ser Ile Thr Ser Leu Val Lys Gln His Ile Ser Asp 
                725                 730                 735     


Ala Lys Leu Thr Ala Gln Ser Glu Glu Lys Leu Val Tyr Ile Leu Pro 
            740                 745                 750         


Leu Glu Arg Thr Asn Lys Phe Pro Glu Leu Tyr Arg Asp Leu Asp Arg 
        755                 760                 765             


Cys Ser Asn Gln Gly Ile Glu Asp Tyr Gly Val Ser Ile Thr Thr Leu 
    770                 775                 780                 


Asn Glu Val Phe Leu Lys Leu Glu Gly Lys Ser Thr Ile Asp Glu Ser 
785                 790                 795                 800 


Asp Ile Gly Ile Trp Gly Gln Leu Gln Thr Asp Gly Ala Lys Asp Ile 
                805                 810                 815     


Gly Ser Leu Val Glu Leu Glu Gln Val Leu Ser Ser Phe His Glu Thr 
            820                 825                 830         


Arg Lys Thr Ile Ser Gly Val Ala Leu Trp Arg Gln Gln Val Cys Ala 
        835                 840                 845             


Ile Ala Lys Val Arg Phe Leu Lys Leu Lys Lys Glu Arg Lys Ser Leu 
    850                 855                 860                 


Trp Thr Ile Leu Leu Leu Phe Gly Ile Ser Phe Ile Pro Gln Leu Leu 
865                 870                 875                 880 


Glu His Leu Phe Tyr Glu Ser Tyr Gln Lys Ser Tyr Pro Trp Glu Leu 
                885                 890                 895     


Ser Pro Asn Thr Tyr Phe Leu Ser Pro Gly Gln Gln Pro Gln Asp Pro 
            900                 905                 910         


Leu Thr His Leu Leu Val Ile Asn Lys Thr Gly Ser Thr Ile Asp Asn 
        915                 920                 925             


Phe Leu His Ser Leu Arg Arg Gln Asn Ile Ala Ile Glu Val Asp Ala 
    930                 935                 940                 


Phe Gly Thr Arg Asn Gly Thr Asp Asp Pro Ser Tyr Asn Gly Ala Ile 
945                 950                 955                 960 


Ile Val Ser Gly Asp Glu Lys Asp His Arg Phe Ser Ile Ala Cys Asn 
                965                 970                 975     


Thr Lys Arg Leu Asn Cys Phe Pro Val Leu Leu Asp Val Ile Ser Asn 
            980                 985                 990         


Gly Leu Leu Gly Ile Phe Asn Ser  Ser Glu His Ile Gln  Thr Asp Arg 
        995                 1000                 1005             


Ser Thr  Phe Phe Glu Glu His  Met Asp Tyr Glu Tyr  Gly Tyr Arg 
    1010                 1015                 1020             


Ser Asn  Thr Phe Phe Trp Ile  Pro Met Ala Ala Ser  Phe Thr Pro 
    1025                 1030                 1035             


Tyr Ile  Ala Met Ser Ser Ile  Gly Asp Tyr Lys Lys  Lys Ala His 
    1040                 1045                 1050             


Ser Gln  Leu Arg Ile Ser Gly  Leu Tyr Pro Ser Ala  Tyr Trp Phe 
    1055                 1060                 1065             


Gly Gln  Ala Leu Val Asp Val  Ser Leu Tyr Phe Leu  Ile Leu Leu 
    1070                 1075                 1080             


Leu Met  Gln Ile Met Asp Tyr  Ile Phe Ser Pro Glu  Glu Ile Ile 
    1085                 1090                 1095             


Phe Ile  Ile Gln Asn Leu Leu  Ile Gln Ile Leu Cys  Ser Ile Gly 
    1100                 1105                 1110             


Tyr Val  Ser Ser Leu Val Phe  Leu Thr Tyr Val Ile  Ser Phe Ile 
    1115                 1120                 1125             


Phe Arg  Asn Gly Arg Lys Asn  Ser Gly Ile Trp Ser  Phe Phe Phe 
    1130                 1135                 1140             


Leu Ile  Val Val Ile Phe Ser  Ile Val Ala Thr Asp  Leu Asn Glu 
    1145                 1150                 1155             


Tyr Gly  Phe Leu Gly Leu Phe  Phe Gly Thr Met Leu  Ile Pro Pro 
    1160                 1165                 1170             


Phe Thr  Leu Ile Gly Ser Leu  Phe Ile Phe Ser Glu  Ile Ser Pro 
    1175                 1180                 1185             


Asp Ser  Met Asp Tyr Leu Gly  Ala Ser Glu Ser Glu  Ile Val Tyr 
    1190                 1195                 1200             


Leu Ala  Leu Leu Ile Pro Tyr  Leu His Phe Leu Ile  Phe Leu Phe 
    1205                 1210                 1215             


Ile Leu  Arg Cys Leu Glu Met  Asn Cys Arg Lys Lys  Leu Met Arg 
    1220                 1225                 1230             


Lys Asp  Pro Val Phe Arg Ile  Ser Pro Arg Ser Asn  Ala Ile Phe 
    1235                 1240                 1245             


Pro Asn  Pro Glu Glu Pro Glu  Gly Glu Glu Glu Asp  Ile Gln Met 
    1250                 1255                 1260             


Glu Arg  Met Arg Thr Val Asn  Ala Met Ala Val Arg  Asp Phe Asp 
    1265                 1270                 1275             


Glu Thr  Pro Val Ile Ile Ala  Ser Cys Leu Arg Lys  Glu Tyr Ala 
    1280                 1285                 1290             


Gly Lys  Lys Lys Asn Cys Phe  Ser Lys Arg Lys Lys  Lys Ile Ala 
    1295                 1300                 1305             


Thr Arg  Asn Val Ser Phe Cys  Val Lys Lys Gly Glu  Val Ile Gly 
    1310                 1315                 1320             


Leu Leu  Gly His Asn Gly Ala  Gly Lys Ser Thr Thr  Ile Lys Met 
    1325                 1330                 1335             


Ile Thr  Gly Asp Thr Lys Pro  Thr Ala Gly Gln Val  Ile Leu Lys 
    1340                 1345                 1350             


Gly Ser  Gly Gly Gly Glu Pro  Leu Gly Phe Leu Gly  Tyr Cys Pro 
    1355                 1360                 1365             


Gln Glu  Asn Ala Leu Trp Pro  Asn Leu Thr Val Arg  Gln His Leu 
    1370                 1375                 1380             


Glu Val  Tyr Ala Ala Val Lys  Gly Leu Arg Lys Gly  Asp Ala Met 
    1385                 1390                 1395             


Ile Ala  Ile Thr Arg Leu Val  Asp Ala Leu Lys Leu  Gln Asp Gln 
    1400                 1405                 1410             


Leu Lys  Ala Pro Val Lys Thr  Leu Ser Glu Gly Ile  Lys Arg Lys 
    1415                 1420                 1425             


Leu Cys  Phe Val Leu Ser Ile  Leu Gly Asn Pro Ser  Val Val Leu 
    1430                 1435                 1440             


Leu Asp  Glu Pro Ser Thr Gly  Met Asp Pro Glu Gly  Gln Gln Gln 
    1445                 1450                 1455             


Met Trp  Gln Val Ile Arg Ala  Thr Phe Arg Asn Thr  Glu Arg Gly 
    1460                 1465                 1470             


Ala Leu  Leu Thr Thr His Tyr  Met Ala Glu Ala Glu  Ala Val Cys 
    1475                 1480                 1485             


Asp Arg  Val Ala Ile Met Val  Ser Gly Arg Leu Arg  Cys Ile Gly 
    1490                 1495                 1500             


Ser Ile  Gln His Leu Lys Ser  Lys Phe Gly Lys Asp  Tyr Leu Leu 
    1505                 1510                 1515             


Glu Met  Lys Leu Lys Asn Leu  Ala Gln Met Glu Pro  Leu His Ala 
    1520                 1525                 1530             


Glu Ile  Leu Arg Leu Phe Pro  Gln Ala Ala Gln Gln  Glu Arg Phe 
    1535                 1540                 1545             


Ser Ser  Leu Met Val Tyr Lys  Leu Pro Val Glu Asp  Val Arg Pro 
    1550                 1555                 1560             


Leu Ser  Gln Ala Phe Phe Lys  Leu Glu Ile Val Lys  Gln Ser Phe 
    1565                 1570                 1575             


Asp Leu  Glu Glu Tyr Ser Leu  Ser Gln Ser Thr Leu  Glu Gln Val 
    1580                 1585                 1590             


Phe Leu  Glu Leu Ser Lys Glu  Gln Glu Leu Gly Asp  Leu Glu Glu 
    1595                 1600                 1605             


Asp Phe  Asp Pro Ser Val Lys  Trp Lys Leu Leu Leu  Gln Glu Glu 
    1610                 1615                 1620             


Pro 
    


<210>  139
<211>  2436
<212>  PRT
<213>  homo sapiens

<400>  139

Met Gly Phe Leu His Gln Leu Gln Leu Leu Leu Trp Lys Asn Val Thr 
1               5                   10                  15      


Leu Lys Arg Arg Ser Pro Trp Val Leu Ala Phe Glu Ile Phe Ile Pro 
            20                  25                  30          


Leu Val Leu Phe Phe Ile Leu Leu Gly Leu Arg Gln Lys Lys Pro Thr 
        35                  40                  45              


Ile Ser Val Lys Glu Val Pro Phe Tyr Thr Ala Ala Pro Leu Thr Ser 
    50                  55                  60                  


Ala Gly Ile Leu Pro Val Met Gln Ser Leu Cys Pro Asp Gly Gln Arg 
65                  70                  75                  80  


Asp Glu Phe Gly Phe Leu Gln Tyr Ala Asn Ser Thr Val Thr Gln Leu 
                85                  90                  95      


Leu Glu Arg Leu Asp Arg Val Val Glu Glu Gly Asn Leu Phe Asp Pro 
            100                 105                 110         


Ala Arg Pro Ser Leu Gly Ser Glu Leu Glu Ala Leu Arg Gln His Leu 
        115                 120                 125             


Glu Ala Leu Ser Ala Gly Pro Gly Thr Ser Gly Ser His Leu Asp Arg 
    130                 135                 140                 


Ser Thr Val Ser Ser Phe Ser Leu Asp Ser Val Ala Arg Asn Pro Gln 
145                 150                 155                 160 


Glu Leu Trp Arg Phe Leu Thr Gln Asn Leu Ser Leu Pro Asn Ser Thr 
                165                 170                 175     


Ala Gln Ala Leu Leu Ala Ala Arg Val Asp Pro Pro Glu Val Tyr His 
            180                 185                 190         


Leu Leu Phe Gly Pro Ser Ser Ala Leu Asp Ser Gln Ser Gly Leu His 
        195                 200                 205             


Lys Gly Gln Glu Pro Trp Ser Arg Leu Gly Gly Asn Pro Leu Phe Arg 
    210                 215                 220                 


Met Glu Glu Leu Leu Leu Ala Pro Ala Leu Leu Glu Gln Leu Thr Cys 
225                 230                 235                 240 


Thr Pro Gly Ser Gly Glu Leu Gly Arg Ile Leu Thr Val Pro Glu Ser 
                245                 250                 255     


Gln Lys Gly Ala Leu Gln Gly Tyr Arg Asp Ala Val Cys Ser Gly Gln 
            260                 265                 270         


Ala Ala Ala Arg Ala Arg Arg Phe Ser Gly Leu Ser Ala Glu Leu Arg 
        275                 280                 285             


Asn Gln Leu Asp Val Ala Lys Val Ser Gln Gln Leu Gly Leu Asp Ala 
    290                 295                 300                 


Pro Asn Gly Ser Asp Ser Ser Pro Gln Ala Pro Pro Pro Arg Arg Leu 
305                 310                 315                 320 


Gln Ala Leu Leu Gly Asp Leu Leu Asp Ala Gln Lys Val Leu Gln Asp 
                325                 330                 335     


Val Asp Val Leu Ser Ala Leu Ala Leu Leu Leu Pro Gln Gly Ala Cys 
            340                 345                 350         


Thr Gly Arg Thr Pro Gly Pro Pro Ala Ser Gly Ala Gly Gly Ala Ala 
        355                 360                 365             


Asn Gly Thr Gly Ala Gly Ala Val Met Gly Pro Asn Ala Thr Ala Glu 
    370                 375                 380                 


Glu Gly Ala Pro Ser Ala Ala Ala Leu Ala Thr Pro Asp Thr Leu Gln 
385                 390                 395                 400 


Gly Gln Cys Ser Ala Phe Val Gln Leu Trp Ala Gly Leu Gln Pro Ile 
                405                 410                 415     


Leu Cys Gly Asn Asn Arg Thr Ile Glu Pro Glu Ala Leu Arg Arg Gly 
            420                 425                 430         


Asn Met Ser Ser Leu Gly Phe Thr Ser Lys Glu Gln Arg Asn Leu Gly 
        435                 440                 445             


Leu Leu Val His Leu Met Thr Ser Asn Pro Lys Ile Leu Tyr Ala Pro 
    450                 455                 460                 


Ala Gly Ser Glu Val Asp Arg Val Ile Leu Lys Ala Asn Glu Thr Phe 
465                 470                 475                 480 


Ala Phe Val Gly Asn Val Thr His Tyr Ala Gln Val Trp Leu Asn Ile 
                485                 490                 495     


Ser Ala Glu Ile Arg Ser Phe Leu Glu Gln Gly Arg Leu Gln Gln His 
            500                 505                 510         


Leu Arg Trp Leu Gln Gln Tyr Val Ala Glu Leu Arg Leu His Pro Glu 
        515                 520                 525             


Ala Leu Asn Leu Ser Leu Asp Glu Leu Pro Pro Ala Leu Arg Gln Asp 
    530                 535                 540                 


Asn Phe Ser Leu Pro Ser Gly Met Ala Leu Leu Gln Gln Leu Asp Thr 
545                 550                 555                 560 


Ile Asp Asn Ala Ala Cys Gly Trp Ile Gln Phe Met Ser Lys Val Ser 
                565                 570                 575     


Val Asp Ile Phe Lys Gly Phe Pro Asp Glu Glu Ser Ile Val Asn Tyr 
            580                 585                 590         


Thr Leu Asn Gln Ala Tyr Gln Asp Asn Val Thr Val Phe Ala Ser Val 
        595                 600                 605             


Ile Phe Gln Thr Arg Lys Asp Gly Ser Leu Pro Pro His Val His Tyr 
    610                 615                 620                 


Lys Ile Arg Gln Asn Ser Ser Phe Thr Glu Lys Thr Asn Glu Ile Arg 
625                 630                 635                 640 


Arg Ala Tyr Trp Arg Pro Gly Pro Asn Thr Gly Gly Arg Phe Tyr Phe 
                645                 650                 655     


Leu Tyr Gly Phe Val Trp Ile Gln Asp Met Met Glu Arg Ala Ile Ile 
            660                 665                 670         


Asp Thr Phe Val Gly His Asp Val Val Glu Pro Gly Ser Tyr Val Gln 
        675                 680                 685             


Met Phe Pro Tyr Pro Cys Tyr Thr Arg Asp Asp Phe Leu Phe Val Ile 
    690                 695                 700                 


Glu His Met Met Pro Leu Cys Met Val Ile Ser Trp Val Tyr Ser Val 
705                 710                 715                 720 


Ala Met Thr Ile Gln His Ile Val Ala Glu Lys Glu His Arg Leu Lys 
                725                 730                 735     


Glu Val Met Lys Thr Met Gly Leu Asn Asn Ala Val His Trp Val Ala 
            740                 745                 750         


Trp Phe Ile Thr Gly Phe Val Gln Leu Ser Ile Ser Val Thr Ala Leu 
        755                 760                 765             


Thr Ala Ile Leu Lys Tyr Gly Gln Val Leu Met His Ser His Val Val 
    770                 775                 780                 


Ile Ile Trp Leu Phe Leu Ala Val Tyr Ala Val Ala Thr Ile Met Phe 
785                 790                 795                 800 


Cys Phe Leu Val Ser Val Leu Tyr Ser Lys Ala Lys Leu Ala Ser Ala 
                805                 810                 815     


Cys Gly Gly Ile Ile Tyr Phe Leu Ser Tyr Val Pro Tyr Met Tyr Val 
            820                 825                 830         


Ala Ile Arg Glu Glu Val Ala His Asp Lys Ile Thr Ala Phe Glu Lys 
        835                 840                 845             


Cys Ile Ala Ser Leu Met Ser Thr Thr Ala Phe Gly Leu Gly Ser Lys 
    850                 855                 860                 


Tyr Phe Ala Leu Tyr Glu Val Ala Gly Val Gly Ile Gln Trp His Thr 
865                 870                 875                 880 


Phe Ser Gln Ser Pro Val Glu Gly Asp Asp Phe Asn Leu Leu Leu Ala 
                885                 890                 895     


Val Thr Met Leu Met Val Asp Ala Val Val Tyr Gly Ile Leu Thr Trp 
            900                 905                 910         


Tyr Ile Glu Ala Val His Pro Gly Met Tyr Gly Leu Pro Arg Pro Trp 
        915                 920                 925             


Tyr Phe Pro Leu Gln Lys Ser Tyr Trp Leu Gly Ser Gly Arg Thr Glu 
    930                 935                 940                 


Ala Trp Glu Trp Ser Trp Pro Trp Ala Arg Thr Pro Arg Leu Ser Val 
945                 950                 955                 960 


Met Glu Glu Asp Gln Ala Cys Ala Met Glu Ser Arg Arg Phe Glu Glu 
                965                 970                 975     


Thr Arg Gly Met Glu Glu Glu Pro Thr His Leu Pro Leu Val Val Cys 
            980                 985                 990         


Val Asp Lys Leu Thr Lys Val Tyr  Lys Asp Asp Lys Lys  Leu Ala Leu 
        995                 1000                 1005             


Asn Lys  Leu Ser Leu Asn Leu  Tyr Glu Asn Gln Val  Val Ser Phe 
    1010                 1015                 1020             


Leu Gly  His Asn Gly Ala Gly  Lys Thr Thr Thr Met  Ser Ile Leu 
    1025                 1030                 1035             


Thr Gly  Leu Phe Pro Pro Thr  Ser Gly Ser Ala Thr  Ile Tyr Gly 
    1040                 1045                 1050             


His Asp  Ile Arg Thr Glu Met  Asp Glu Ile Arg Lys  Asn Leu Gly 
    1055                 1060                 1065             


Met Cys  Pro Gln His Asn Val  Leu Phe Asp Arg Leu  Thr Val Glu 
    1070                 1075                 1080             


Glu His  Leu Trp Phe Tyr Ser  Arg Leu Lys Ser Met  Ala Gln Glu 
    1085                 1090                 1095             


Glu Ile  Arg Arg Glu Met Asp  Lys Met Ile Glu Asp  Leu Glu Leu 
    1100                 1105                 1110             


Ser Asn  Lys Arg His Ser Leu  Val Gln Thr Leu Ser  Gly Gly Met 
    1115                 1120                 1125             


Lys Arg  Lys Leu Ser Val Ala  Ile Ala Phe Val Gly  Gly Ser Arg 
    1130                 1135                 1140             


Ala Ile  Ile Leu Asp Glu Pro  Thr Ala Gly Val Asp  Pro Tyr Ala 
    1145                 1150                 1155             


Arg Arg  Ala Ile Trp Asp Leu  Ile Leu Lys Tyr Lys  Pro Gly Arg 
    1160                 1165                 1170             


Thr Ile  Leu Leu Ser Thr His  His Met Asp Glu Ala  Asp Leu Leu 
    1175                 1180                 1185             


Gly Asp  Arg Ile Ala Ile Ile  Ser His Gly Lys Leu  Lys Cys Cys 
    1190                 1195                 1200             


Gly Ser  Pro Leu Phe Leu Lys  Gly Thr Tyr Gly Asp  Gly Tyr Arg 
    1205                 1210                 1215             


Leu Thr  Leu Val Lys Arg Pro  Ala Glu Pro Gly Gly  Pro Gln Glu 
    1220                 1225                 1230             


Pro Gly  Leu Ala Ser Ser Pro  Pro Gly Arg Ala Pro  Leu Ser Ser 
    1235                 1240                 1245             


Cys Ser  Glu Leu Gln Val Ser  Gln Phe Ile Arg Lys  His Val Ala 
    1250                 1255                 1260             


Ser Cys  Leu Leu Val Ser Asp  Thr Ser Thr Glu Leu  Ser Tyr Ile 
    1265                 1270                 1275             


Leu Pro  Ser Glu Ala Ala Lys  Lys Gly Ala Phe Glu  Arg Leu Phe 
    1280                 1285                 1290             


Gln His  Leu Glu Arg Ser Leu  Asp Ala Leu His Leu  Ser Ser Phe 
    1295                 1300                 1305             


Gly Leu  Met Asp Thr Thr Leu  Glu Glu Val Phe Leu  Lys Val Ser 
    1310                 1315                 1320             


Glu Glu  Asp Gln Ser Leu Glu  Asn Ser Glu Ala Asp  Val Lys Glu 
    1325                 1330                 1335             


Ser Arg  Lys Asp Val Leu Pro  Gly Ala Glu Gly Pro  Ala Ser Gly 
    1340                 1345                 1350             


Glu Gly  His Ala Gly Asn Leu  Ala Arg Cys Ser Glu  Leu Thr Gln 
    1355                 1360                 1365             


Ser Gln  Ala Ser Leu Gln Ser  Ala Ser Ser Val Gly  Ser Ala Arg 
    1370                 1375                 1380             


Gly Asp  Glu Gly Ala Gly Tyr  Thr Asp Val Tyr Gly  Asp Tyr Arg 
    1385                 1390                 1395             


Pro Leu  Phe Asp Asn Pro Gln  Asp Pro Asp Asn Val  Ser Leu Gln 
    1400                 1405                 1410             


Glu Val  Glu Ala Glu Ala Leu  Ser Arg Val Gly Gln  Gly Ser Arg 
    1415                 1420                 1425             


Lys Leu  Asp Gly Gly Trp Leu  Lys Val Arg Gln Phe  His Gly Leu 
    1430                 1435                 1440             


Leu Val  Lys Arg Phe His Cys  Ala Arg Arg Asn Ser  Lys Ala Leu 
    1445                 1450                 1455             


Phe Ser  Gln Ile Leu Leu Pro  Ala Phe Phe Val Cys  Val Ala Met 
    1460                 1465                 1470             


Thr Val  Ala Leu Ser Val Pro  Glu Ile Gly Asp Leu  Pro Pro Leu 
    1475                 1480                 1485             


Val Leu  Ser Pro Ser Gln Tyr  His Asn Tyr Thr Gln  Pro Arg Gly 
    1490                 1495                 1500             


Asn Phe  Ile Pro Tyr Ala Asn  Glu Glu Arg Arg Glu  Tyr Arg Leu 
    1505                 1510                 1515             


Arg Leu  Ser Pro Asp Ala Ser  Pro Gln Gln Leu Val  Ser Thr Phe 
    1520                 1525                 1530             


Arg Leu  Pro Ser Gly Val Gly  Ala Thr Cys Val Leu  Lys Ser Pro 
    1535                 1540                 1545             


Ala Asn  Gly Ser Leu Gly Pro  Thr Leu Asn Leu Ser  Ser Gly Glu 
    1550                 1555                 1560             


Ser Arg  Leu Leu Ala Ala Arg  Phe Phe Asp Ser Met  Cys Leu Glu 
    1565                 1570                 1575             


Ser Phe  Thr Gln Gly Leu Pro  Leu Ser Asn Phe Val  Pro Pro Pro 
    1580                 1585                 1590             


Pro Ser  Pro Ala Pro Ser Asp  Ser Pro Ala Ser Pro  Asp Glu Asp 
    1595                 1600                 1605             


Leu Gln  Ala Trp Asn Val Ser  Leu Pro Pro Thr Ala  Gly Pro Glu 
    1610                 1615                 1620             


Met Trp  Thr Ser Ala Pro Ser  Leu Pro Arg Leu Val  Arg Glu Pro 
    1625                 1630                 1635             


Val Arg  Cys Thr Cys Ser Ala  Gln Gly Thr Gly Phe  Ser Cys Pro 
    1640                 1645                 1650             


Ser Ser  Val Gly Gly His Pro  Pro Gln Met Arg Val  Val Thr Gly 
    1655                 1660                 1665             


Asp Ile  Leu Thr Asp Ile Thr  Gly His Asn Val Ser  Glu Tyr Leu 
    1670                 1675                 1680             


Leu Phe  Thr Ser Asp Arg Phe  Arg Leu His Arg Tyr  Gly Ala Ile 
    1685                 1690                 1695             


Thr Phe  Gly Asn Val Leu Lys  Ser Ile Pro Ala Ser  Phe Gly Thr 
    1700                 1705                 1710             


Arg Ala  Pro Pro Met Val Arg  Lys Ile Ala Val Arg  Arg Ala Ala 
    1715                 1720                 1725             


Gln Val  Phe Tyr Asn Asn Lys  Gly Tyr His Ser Met  Pro Thr Tyr 
    1730                 1735                 1740             


Leu Asn  Ser Leu Asn Asn Ala  Ile Leu Arg Ala Asn  Leu Pro Lys 
    1745                 1750                 1755             


Ser Lys  Gly Asn Pro Ala Ala  Tyr Gly Ile Thr Val  Thr Asn His 
    1760                 1765                 1770             


Pro Met  Asn Lys Thr Ser Ala  Ser Leu Ser Leu Asp  Tyr Leu Leu 
    1775                 1780                 1785             


Gln Gly  Thr Asp Val Val Ile  Ala Ile Phe Ile Ile  Val Ala Met 
    1790                 1795                 1800             


Ser Phe  Val Pro Ala Ser Phe  Val Val Phe Leu Val  Ala Glu Lys 
    1805                 1810                 1815             


Ser Thr  Lys Ala Lys His Leu  Gln Phe Val Ser Gly  Cys Asn Pro 
    1820                 1825                 1830             


Ile Ile  Tyr Trp Leu Ala Asn  Tyr Val Trp Asp Met  Leu Asn Tyr 
    1835                 1840                 1845             


Leu Val  Pro Ala Thr Cys Cys  Val Ile Ile Leu Phe  Val Phe Asp 
    1850                 1855                 1860             


Leu Pro  Ala Tyr Thr Ser Pro  Thr Asn Phe Pro Ala  Val Leu Ser 
    1865                 1870                 1875             


Leu Phe  Leu Leu Tyr Gly Trp  Ser Ile Thr Pro Ile  Met Tyr Pro 
    1880                 1885                 1890             


Ala Ser  Phe Trp Phe Glu Val  Pro Ser Ser Ala Tyr  Val Phe Leu 
    1895                 1900                 1905             


Ile Val  Ile Asn Leu Phe Ile  Gly Ile Thr Ala Thr  Val Ala Thr 
    1910                 1915                 1920             


Phe Leu  Leu Gln Leu Phe Glu  His Asp Lys Asp Leu  Lys Val Val 
    1925                 1930                 1935             


Asn Ser  Tyr Leu Lys Ser Cys  Phe Leu Ile Phe Pro  Asn Tyr Asn 
    1940                 1945                 1950             


Leu Gly  His Gly Leu Met Glu  Met Ala Tyr Asn Glu  Tyr Ile Asn 
    1955                 1960                 1965             


Glu Tyr  Tyr Ala Lys Ile Gly  Gln Phe Asp Lys Met  Lys Ser Pro 
    1970                 1975                 1980             


Phe Glu  Trp Asp Ile Val Thr  Arg Gly Leu Val Ala  Met Ala Val 
    1985                 1990                 1995             


Glu Gly  Val Val Gly Phe Leu  Leu Thr Ile Met Cys  Gln Tyr Asn 
    2000                 2005                 2010             


Phe Leu  Arg Arg Pro Gln Arg  Met Pro Val Ser Thr  Lys Pro Val 
    2015                 2020                 2025             


Glu Asp  Asp Val Asp Val Ala  Ser Glu Arg Gln Arg  Val Leu Arg 
    2030                 2035                 2040             


Gly Asp  Ala Asp Asn Asp Met  Val Lys Ile Glu Asn  Leu Thr Lys 
    2045                 2050                 2055             


Val Tyr  Lys Ser Arg Lys Ile  Gly Arg Ile Leu Ala  Val Asp Arg 
    2060                 2065                 2070             


Leu Cys  Leu Gly Val Arg Leu  Gly Glu Cys Phe Gly  Leu Leu Gly 
    2075                 2080                 2085             


Val Asn  Gly Ala Gly Lys Thr  Ser Thr Phe Lys Met  Leu Thr Gly 
    2090                 2095                 2100             


Asp Glu  Ser Thr Thr Gly Gly  Glu Ala Phe Val Asn  Gly His Ser 
    2105                 2110                 2115             


Val Leu  Lys Glu Leu Leu Gln  Val Gln Gln Ser Leu  Gly Tyr Cys 
    2120                 2125                 2130             


Pro Gln  Cys Asp Ala Leu Phe  Asp Glu Leu Thr Ala  Arg Glu His 
    2135                 2140                 2145             


Leu Gln  Leu Tyr Thr Arg Leu  Arg Gly Ile Ser Trp  Lys Asp Glu 
    2150                 2155                 2160             


Ala Arg  Val Val Lys Trp Ala  Leu Glu Lys Leu Glu  Leu Thr Lys 
    2165                 2170                 2175             


Tyr Ala  Asp Lys Pro Ala Gly  Thr Tyr Ser Gly Gly  Asn Lys Arg 
    2180                 2185                 2190             


Lys Leu  Ser Thr Ala Ile Ala  Leu Ile Gly Tyr Pro  Ala Phe Ile 
    2195                 2200                 2205             


Phe Leu  Asp Glu Pro Thr Thr  Gly Met Asp Pro Lys  Ala Arg Arg 
    2210                 2215                 2220             


Phe Leu  Trp Asn Leu Ile Leu  Asp Leu Ile Lys Thr  Gly Arg Ser 
    2225                 2230                 2235             


Val Val  Leu Thr Ser His Ser  Met Glu Glu Cys Glu  Ala Leu Cys 
    2240                 2245                 2250             


Thr Arg  Leu Ala Ile Met Val  Asn Gly Arg Leu Arg  Cys Leu Gly 
    2255                 2260                 2265             


Ser Ile  Gln His Leu Lys Asn  Arg Phe Gly Asp Gly  Tyr Met Ile 
    2270                 2275                 2280             


Thr Val  Arg Thr Lys Ser Ser  Gln Ser Val Lys Asp  Val Val Arg 
    2285                 2290                 2295             


Phe Phe  Asn Arg Asn Phe Pro  Glu Ala Met Leu Lys  Glu Arg His 
    2300                 2305                 2310             


His Thr  Lys Val Gln Tyr Gln  Leu Lys Ser Glu His  Ile Ser Leu 
    2315                 2320                 2325             


Ala Gln  Val Phe Ser Lys Met  Glu Gln Val Ser Gly  Val Leu Gly 
    2330                 2335                 2340             


Ile Glu  Asp Tyr Ser Val Ser  Gln Thr Thr Leu Asp  Asn Val Phe 
    2345                 2350                 2355             


Val Asn  Phe Ala Lys Lys Gln  Ser Asp Asn Leu Glu  Gln Gln Glu 
    2360                 2365                 2370             


Thr Glu  Pro Pro Ser Ala Leu  Gln Ser Pro Leu Gly  Cys Leu Leu 
    2375                 2380                 2385             


Ser Leu  Leu Arg Pro Arg Ser  Ala Pro Thr Glu Leu  Arg Ala Leu 
    2390                 2395                 2400             


Val Ala  Asp Glu Pro Glu Asp  Leu Asp Thr Glu Asp  Glu Gly Leu 
    2405                 2410                 2415             


Ile Ser  Phe Glu Glu Glu Arg  Ala Gln Leu Ser Phe  Asn Thr Asp 
    2420                 2425                 2430             


Thr Leu  Cys 
    2435     


<210>  140
<211>  4624
<212>  PRT
<213>  homo sapiens

<400>  140

Met Phe Arg Ile Gly Arg Arg Gln Leu Trp Lys His Ser Val Thr Arg 
1               5                   10                  15      


Val Leu Thr Gln Arg Leu Lys Gly Glu Lys Glu Ala Lys Arg Ala Leu 
            20                  25                  30          


Leu Asp Ala Arg His Asn Tyr Leu Phe Ala Ile Val Ala Ser Cys Leu 
        35                  40                  45              


Asp Leu Asn Lys Thr Glu Val Glu Asp Ala Ile Leu Glu Gly Asn Gln 
    50                  55                  60                  


Ile Glu Arg Ile Asp Gln Leu Phe Ala Val Gly Gly Leu Arg His Leu 
65                  70                  75                  80  


Met Phe Tyr Tyr Gln Asp Val Glu Glu Ala Glu Thr Gly Gln Leu Gly 
                85                  90                  95      


Ser Leu Gly Gly Val Asn Leu Val Ser Gly Lys Ile Lys Lys Pro Lys 
            100                 105                 110         


Val Phe Val Thr Glu Gly Asn Asp Val Ala Leu Thr Gly Val Cys Val 
        115                 120                 125             


Phe Phe Ile Arg Thr Asp Pro Ser Lys Ala Ile Thr Pro Asp Asn Ile 
    130                 135                 140                 


His Gln Glu Val Ser Phe Asn Met Leu Asp Ala Ala Asp Gly Gly Leu 
145                 150                 155                 160 


Leu Asn Ser Val Arg Arg Leu Leu Ser Asp Ile Phe Ile Pro Ala Leu 
                165                 170                 175     


Arg Ala Thr Ser His Gly Trp Gly Glu Leu Glu Gly Leu Gln Asp Ala 
            180                 185                 190         


Ala Asn Ile Arg Gln Glu Phe Leu Ser Ser Leu Glu Gly Phe Val Asn 
        195                 200                 205             


Val Leu Ser Gly Ala Gln Glu Ser Leu Lys Glu Lys Val Asn Leu Arg 
    210                 215                 220                 


Lys Cys Asp Ile Leu Glu Leu Lys Thr Leu Lys Glu Pro Thr Asp Tyr 
225                 230                 235                 240 


Leu Thr Leu Ala Asn Asn Pro Glu Thr Leu Gly Lys Ile Glu Asp Cys 
                245                 250                 255     


Met Lys Val Trp Ile Lys Gln Thr Glu Gln Val Leu Ala Glu Asn Asn 
            260                 265                 270         


Gln Leu Leu Lys Glu Ala Asp Asp Val Gly Pro Arg Ala Glu Leu Glu 
        275                 280                 285             


His Trp Lys Lys Arg Leu Ser Lys Phe Asn Tyr Leu Leu Glu Gln Leu 
    290                 295                 300                 


Lys Ser Pro Asp Val Lys Ala Val Leu Ala Val Leu Ala Ala Ala Lys 
305                 310                 315                 320 


Ser Lys Leu Leu Lys Thr Trp Arg Glu Met Asp Ile Arg Ile Thr Asp 
                325                 330                 335     


Ala Thr Asn Glu Ala Lys Asp Asn Val Lys Tyr Leu Tyr Thr Leu Glu 
            340                 345                 350         


Lys Cys Cys Asp Pro Leu Tyr Ser Ser Asp Pro Leu Ser Met Met Asp 
        355                 360                 365             


Ala Ile Pro Thr Leu Ile Asn Ala Ile Lys Met Ile Tyr Ser Ile Ser 
    370                 375                 380                 


His Tyr Tyr Asn Thr Ser Glu Lys Ile Thr Ser Leu Phe Val Lys Val 
385                 390                 395                 400 


Thr Asn Gln Ile Ile Ser Ala Cys Lys Ala Tyr Ile Thr Asn Asn Gly 
                405                 410                 415     


Thr Ala Ser Ile Trp Asn Gln Pro Gln Asp Val Val Glu Glu Lys Ile 
            420                 425                 430         


Leu Ser Ala Ile Lys Leu Lys Gln Glu Tyr Gln Leu Cys Phe His Lys 
        435                 440                 445             


Thr Lys Gln Lys Leu Lys Gln Asn Pro Asn Ala Lys Gln Phe Asp Phe 
    450                 455                 460                 


Ser Glu Met Tyr Ile Phe Gly Lys Phe Glu Thr Phe His Arg Arg Leu 
465                 470                 475                 480 


Ala Lys Ile Ile Asp Ile Phe Thr Thr Leu Lys Thr Tyr Ser Val Leu 
                485                 490                 495     


Gln Asp Ser Thr Ile Glu Gly Leu Glu Asp Met Ala Thr Lys Tyr Gln 
            500                 505                 510         


Gly Ile Val Ala Thr Ile Lys Lys Lys Glu Tyr Asn Phe Leu Asp Gln 
        515                 520                 525             


Arg Lys Met Asp Phe Asp Gln Asp Tyr Glu Glu Phe Cys Lys Gln Thr 
    530                 535                 540                 


Asn Asp Leu His Asn Glu Leu Arg Lys Phe Met Asp Val Thr Phe Ala 
545                 550                 555                 560 


Lys Ile Gln Asn Thr Asn Gln Ala Leu Arg Met Leu Lys Lys Phe Glu 
                565                 570                 575     


Arg Leu Asn Ile Pro Asn Leu Gly Ile Asp Asp Lys Tyr Gln Leu Ile 
            580                 585                 590         


Leu Glu Asn Tyr Gly Ala Asp Ile Asp Met Ile Ser Lys Leu Tyr Thr 
        595                 600                 605             


Lys Gln Lys Tyr Asp Pro Pro Leu Ala Arg Asn Gln Pro Pro Ile Ala 
    610                 615                 620                 


Gly Lys Ile Leu Trp Ala Arg Gln Leu Phe His Arg Ile Gln Gln Pro 
625                 630                 635                 640 


Met Gln Leu Phe Gln Gln His Pro Ala Val Leu Ser Thr Ala Glu Ala 
                645                 650                 655     


Lys Pro Ile Ile Arg Ser Tyr Asn Arg Met Ala Lys Val Leu Leu Glu 
            660                 665                 670         


Phe Glu Val Leu Phe His Arg Ala Trp Leu Arg Gln Ile Glu Glu Ile 
        675                 680                 685             


His Val Gly Leu Glu Ala Ser Leu Leu Val Lys Ala Pro Gly Thr Gly 
    690                 695                 700                 


Glu Leu Phe Val Asn Phe Asp Pro Gln Ile Leu Ile Leu Phe Arg Glu 
705                 710                 715                 720 


Thr Glu Cys Met Ala Gln Met Gly Leu Glu Val Ser Pro Leu Ala Thr 
                725                 730                 735     


Ser Leu Phe Gln Lys Arg Asp Arg Tyr Lys Arg Asn Phe Ser Asn Met 
            740                 745                 750         


Lys Met Met Leu Ala Glu Tyr Gln Arg Val Lys Ser Lys Ile Pro Ala 
        755                 760                 765             


Ala Ile Glu Gln Leu Ile Val Pro His Leu Ala Lys Val Asp Glu Ala 
    770                 775                 780                 


Leu Gln Pro Gly Leu Ala Ala Leu Thr Trp Thr Ser Leu Asn Ile Glu 
785                 790                 795                 800 


Ala Tyr Leu Glu Asn Thr Phe Ala Lys Ile Lys Asp Leu Glu Leu Leu 
                805                 810                 815     


Leu Asp Arg Val Asn Asp Leu Ile Glu Phe Arg Ile Asp Ala Ile Leu 
            820                 825                 830         


Glu Glu Met Ser Ser Thr Pro Leu Cys Gln Leu Pro Gln Glu Glu Pro 
        835                 840                 845             


Leu Thr Cys Glu Glu Phe Leu Gln Met Thr Lys Asp Leu Cys Val Asn 
    850                 855                 860                 


Gly Ala Gln Ile Leu His Phe Lys Ser Ser Leu Val Glu Glu Ala Val 
865                 870                 875                 880 


Asn Glu Leu Val Asn Met Leu Leu Asp Val Glu Val Leu Ser Glu Glu 
                885                 890                 895     


Glu Ser Glu Lys Ile Ser Asn Glu Asn Ser Val Asn Tyr Lys Asn Glu 
            900                 905                 910         


Ser Ser Ala Lys Arg Glu Glu Gly Asn Phe Asp Thr Leu Thr Ser Ser 
        915                 920                 925             


Ile Asn Ala Arg Ala Asn Ala Leu Leu Leu Thr Thr Val Thr Arg Lys 
    930                 935                 940                 


Lys Lys Glu Thr Glu Met Leu Gly Glu Glu Ala Arg Glu Leu Leu Ser 
945                 950                 955                 960 


His Phe Asn His Gln Asn Met Asp Ala Leu Leu Lys Val Thr Arg Asn 
                965                 970                 975     


Thr Leu Glu Ala Ile Arg Lys Arg Ile His Ser Ser His Thr Ile Asn 
            980                 985                 990         


Phe Arg Asp Ser Asn Ser Ala Ser  Asn Met Lys Gln Asn  Ser Leu Pro 
        995                 1000                 1005             


Ile Phe  Arg Ala Ser Val Thr  Leu Ala Ile Pro Asn  Ile Val Met 
    1010                 1015                 1020             


Ala Pro  Ala Leu Glu Asp Val  Gln Gln Thr Leu Asn  Lys Ala Val 
    1025                 1030                 1035             


Glu Cys  Ile Ile Ser Val Pro  Lys Gly Val Arg Gln  Trp Ser Ser 
    1040                 1045                 1050             


Glu Leu  Leu Ser Lys Lys Lys  Ile Gln Glu Arg Lys  Met Ala Ala 
    1055                 1060                 1065             


Leu Gln  Ser Asn Glu Asp Ser  Asp Ser Asp Val Glu  Met Gly Glu 
    1070                 1075                 1080             


Asn Glu  Leu Gln Asp Thr Leu  Glu Ile Ala Ser Val  Asn Leu Pro 
    1085                 1090                 1095             


Ile Pro  Val Gln Thr Lys Asn  Tyr Tyr Lys Asn Val  Ser Glu Asn 
    1100                 1105                 1110             


Lys Glu  Ile Val Lys Leu Val  Ser Val Leu Ser Thr  Ile Ile Asn 
    1115                 1120                 1125             


Ser Thr  Lys Lys Glu Val Ile  Thr Ser Met Asp Cys  Phe Lys Arg 
    1130                 1135                 1140             


Tyr Asn  His Ile Trp Gln Lys  Gly Lys Glu Glu Ala  Ile Lys Thr 
    1145                 1150                 1155             


Phe Ile  Thr Gln Ser Pro Leu  Leu Ser Glu Phe Glu  Ser Gln Ile 
    1160                 1165                 1170             


Leu Tyr  Phe Gln Asn Leu Glu  Gln Glu Ile Asn Ala  Glu Pro Glu 
    1175                 1180                 1185             


Tyr Val  Cys Val Gly Ser Ile  Ala Leu Tyr Thr Ala  Asp Leu Lys 
    1190                 1195                 1200             


Phe Ala  Leu Thr Ala Glu Thr  Lys Ala Trp Met Val  Val Ile Gly 
    1205                 1210                 1215             


Arg His  Cys Asn Lys Lys Tyr  Arg Ser Glu Met Glu  Asn Ile Phe 
    1220                 1225                 1230             


Met Leu  Ile Glu Glu Phe Asn  Lys Lys Leu Asn Arg  Pro Ile Lys 
    1235                 1240                 1245             


Asp Leu  Asp Asp Ile Arg Ile  Ala Met Ala Ala Leu  Lys Glu Ile 
    1250                 1255                 1260             


Arg Glu  Glu Gln Ile Ser Ile  Asp Phe Gln Val Gly  Pro Ile Glu 
    1265                 1270                 1275             


Glu Ser  Tyr Ala Leu Leu Asn  Arg Tyr Gly Leu Leu  Ile Ala Arg 
    1280                 1285                 1290             


Glu Glu  Ile Asp Lys Val Asp  Thr Leu His Tyr Ala  Trp Glu Lys 
    1295                 1300                 1305             


Leu Leu  Ala Arg Ala Gly Glu  Val Gln Asn Lys Leu  Val Ser Leu 
    1310                 1315                 1320             


Gln Pro  Ser Phe Lys Lys Glu  Leu Ile Ser Ala Val  Glu Val Phe 
    1325                 1330                 1335             


Leu Gln  Asp Cys His Gln Phe  Tyr Leu Asp Tyr Asp  Leu Asn Gly 
    1340                 1345                 1350             


Pro Met  Ala Ser Gly Leu Lys  Pro Gln Glu Ala Ser  Asp Arg Leu 
    1355                 1360                 1365             


Ile Met  Phe Gln Asn Gln Phe  Asp Asn Ile Tyr Arg  Lys Tyr Ile 
    1370                 1375                 1380             


Thr Tyr  Thr Gly Gly Glu Glu  Leu Phe Gly Leu Pro  Ala Thr Gln 
    1385                 1390                 1395             


Tyr Pro  Gln Leu Leu Glu Ile  Lys Lys Gln Leu Asn  Leu Leu Gln 
    1400                 1405                 1410             


Lys Ile  Tyr Thr Leu Tyr Asn  Ser Val Ile Glu Thr  Val Asn Ser 
    1415                 1420                 1425             


Tyr Tyr  Asp Ile Leu Trp Ser  Glu Val Asn Ile Glu  Lys Ile Asn 
    1430                 1435                 1440             


Asn Glu  Leu Leu Glu Phe Gln  Asn Arg Cys Arg Lys  Leu Pro Arg 
    1445                 1450                 1455             


Ala Leu  Lys Asp Trp Gln Ala  Phe Leu Asp Leu Lys  Lys Ile Ile 
    1460                 1465                 1470             


Asp Asp  Phe Ser Glu Cys Cys  Pro Leu Leu Glu Tyr  Met Ala Ser 
    1475                 1480                 1485             


Lys Ala  Met Met Glu Arg His  Trp Glu Arg Ile Thr  Thr Leu Thr 
    1490                 1495                 1500             


Gly His  Ser Leu Asp Val Gly  Asn Glu Ser Phe Lys  Leu Arg Asn 
    1505                 1510                 1515             


Ile Met  Glu Ala Pro Leu Leu  Lys Tyr Lys Glu Glu  Ile Glu Asp 
    1520                 1525                 1530             


Ile Cys  Ile Ser Ala Val Lys  Glu Arg Asp Ile Glu  Gln Lys Leu 
    1535                 1540                 1545             


Lys Gln  Val Ile Asn Glu Trp  Asp Asn Lys Thr Phe  Thr Phe Gly 
    1550                 1555                 1560             


Ser Phe  Lys Thr Arg Gly Glu  Leu Leu Leu Arg Gly  Asp Ser Thr 
    1565                 1570                 1575             


Ser Glu  Ile Ile Ala Asn Met  Glu Asp Ser Leu Met  Leu Leu Gly 
    1580                 1585                 1590             


Ser Leu  Leu Ser Asn Arg Tyr  Asn Met Pro Phe Lys  Ala Gln Ile 
    1595                 1600                 1605             


Gln Lys  Trp Val Gln Tyr Leu  Ser Asn Ser Thr Asp  Ile Ile Glu 
    1610                 1615                 1620             


Ser Trp  Met Thr Val Gln Asn  Leu Trp Ile Tyr Leu  Glu Ala Val 
    1625                 1630                 1635             


Phe Val  Gly Gly Asp Ile Ala  Lys Gln Leu Pro Lys  Glu Ala Lys 
    1640                 1645                 1650             


Arg Phe  Ser Asn Ile Asp Lys  Ser Trp Val Lys Ile  Met Thr Arg 
    1655                 1660                 1665             


Ala His  Glu Val Pro Ser Val  Val Gln Cys Cys Val  Gly Asp Glu 
    1670                 1675                 1680             


Thr Leu  Gly Gln Leu Leu Pro  His Leu Leu Asp Gln  Leu Glu Ile 
    1685                 1690                 1695             


Cys Gln  Lys Ser Leu Thr Gly  Tyr Leu Glu Lys Lys  Arg Leu Cys 
    1700                 1705                 1710             


Phe Pro  Arg Phe Phe Phe Val  Ser Asp Pro Ala Leu  Leu Glu Ile 
    1715                 1720                 1725             


Leu Gly  Gln Ala Ser Asp Ser  His Thr Ile Gln Ala  His Leu Leu 
    1730                 1735                 1740             


Asn Val  Phe Asp Asn Ile Lys  Ser Val Lys Phe His  Glu Lys Ile 
    1745                 1750                 1755             


Tyr Asp  Arg Ile Leu Ser Ile  Ser Ser Gln Glu Gly  Glu Thr Ile 
    1760                 1765                 1770             


Glu Leu  Asp Lys Pro Val Met  Ala Glu Gly Asn Val  Glu Val Trp 
    1775                 1780                 1785             


Leu Asn  Ser Leu Leu Glu Glu  Ser Gln Ser Ser Leu  His Leu Val 
    1790                 1795                 1800             


Ile Arg  Gln Ala Ala Ala Asn  Ile Gln Glu Thr Gly  Phe Gln Leu 
    1805                 1810                 1815             


Thr Glu  Phe Leu Ser Ser Phe  Pro Ala Gln Val Gly  Leu Leu Gly 
    1820                 1825                 1830             


Ile Gln  Met Ile Trp Thr Arg  Asp Ser Glu Glu Ala  Leu Arg Asn 
    1835                 1840                 1845             


Ala Lys  Phe Asp Lys Lys Ile  Met Gln Lys Thr Asn  Gln Ala Phe 
    1850                 1855                 1860             


Leu Glu  Leu Leu Asn Thr Leu  Ile Asp Val Thr Thr  Arg Asp Leu 
    1865                 1870                 1875             


Ser Ser  Thr Glu Arg Val Lys  Tyr Glu Thr Leu Ile  Thr Ile His 
    1880                 1885                 1890             


Val His  Gln Arg Asp Ile Phe  Asp Asp Leu Cys His  Met His Ile 
    1895                 1900                 1905             


Lys Ser  Pro Met Asp Phe Glu  Trp Leu Lys Gln Cys  Arg Phe Tyr 
    1910                 1915                 1920             


Phe Asn  Glu Asp Ser Asp Lys  Met Met Ile His Ile  Thr Asp Val 
    1925                 1930                 1935             


Ala Phe  Ile Tyr Gln Asn Glu  Phe Leu Gly Cys Thr  Asp Arg Leu 
    1940                 1945                 1950             


Val Ile  Thr Pro Leu Thr Asp  Arg Cys Tyr Ile Thr  Leu Ala Gln 
    1955                 1960                 1965             


Ala Leu  Gly Met Ser Met Gly  Gly Ala Pro Ala Gly  Pro Ala Gly 
    1970                 1975                 1980             


Thr Gly  Lys Thr Glu Thr Thr  Lys Asp Met Gly Arg  Cys Leu Gly 
    1985                 1990                 1995             


Lys Tyr  Val Val Val Phe Asn  Cys Ser Asp Gln Met  Asp Phe Arg 
    2000                 2005                 2010             


Gly Leu  Gly Arg Ile Phe Lys  Gly Leu Ala Gln Ser  Gly Ser Trp 
    2015                 2020                 2025             


Gly Cys  Phe Asp Glu Phe Asn  Arg Ile Asp Leu Pro  Val Leu Ser 
    2030                 2035                 2040             


Val Ala  Ala Gln Gln Ile Ser  Ile Ile Leu Thr Cys  Lys Lys Glu 
    2045                 2050                 2055             


His Lys  Lys Ser Phe Ile Phe  Thr Asp Gly Asp Asn  Val Thr Met 
    2060                 2065                 2070             


Asn Pro  Glu Phe Gly Leu Phe  Leu Thr Met Asn Pro  Gly Tyr Ala 
    2075                 2080                 2085             


Gly Arg  Gln Glu Leu Pro Glu  Asn Leu Lys Ile Asn  Phe Arg Ser 
    2090                 2095                 2100             


Val Ala  Met Met Val Pro Asp  Arg Gln Ile Ile Ile  Arg Val Lys 
    2105                 2110                 2115             


Leu Ala  Ser Cys Gly Phe Ile  Asp Asn Val Val Leu  Ala Arg Lys 
    2120                 2125                 2130             


Phe Phe  Thr Leu Tyr Lys Leu  Cys Glu Glu Gln Leu  Ser Lys Gln 
    2135                 2140                 2145             


Val His  Tyr Asp Phe Gly Leu  Arg Asn Ile Leu Ser  Val Leu Arg 
    2150                 2155                 2160             


Thr Leu  Gly Ala Ala Lys Arg  Ala Asn Pro Met Asp  Thr Glu Ser 
    2165                 2170                 2175             


Thr Ile  Val Met Arg Val Leu  Arg Asp Met Asn Leu  Ser Lys Leu 
    2180                 2185                 2190             


Ile Asp  Glu Asp Glu Pro Leu  Phe Leu Ser Leu Ile  Glu Asp Leu 
    2195                 2200                 2205             


Phe Pro  Asn Ile Leu Leu Asp  Lys Ala Gly Tyr Pro  Glu Leu Glu 
    2210                 2215                 2220             


Ala Ala  Ile Ser Arg Gln Val  Glu Glu Ala Gly Leu  Ile Asn His 
    2225                 2230                 2235             


Pro Pro  Trp Lys Leu Lys Val  Ile Gln Leu Phe Glu  Thr Gln Arg 
    2240                 2245                 2250             


Val Arg  His Gly Met Met Thr  Leu Gly Pro Ser Gly  Ala Gly Lys 
    2255                 2260                 2265             


Thr Thr  Cys Ile His Thr Leu  Met Arg Ala Met Thr  Asp Cys Gly 
    2270                 2275                 2280             


Lys Pro  His Arg Glu Met Arg  Met Asn Pro Lys Ala  Ile Thr Ala 
    2285                 2290                 2295             


Pro Gln  Met Phe Gly Arg Leu  Asp Val Ala Thr Asn  Asp Trp Thr 
    2300                 2305                 2310             


Asp Gly  Ile Phe Ser Thr Leu  Trp Arg Lys Thr Leu  Arg Ala Lys 
    2315                 2320                 2325             


Lys Gly  Glu His Ile Trp Ile  Ile Leu Asp Gly Pro  Val Asp Ala 
    2330                 2335                 2340             


Ile Trp  Ile Glu Asn Leu Asn  Ser Val Leu Asp Asp  Asn Lys Thr 
    2345                 2350                 2355             


Leu Thr  Leu Ala Asn Gly Asp  Arg Ile Pro Met Ala  Pro Asn Cys 
    2360                 2365                 2370             


Lys Ile  Ile Phe Glu Pro His  Asn Ile Asp Asn Ala  Ser Pro Ala 
    2375                 2380                 2385             


Thr Val  Ser Arg Asn Gly Met  Val Phe Met Ser Ser  Ser Ile Leu 
    2390                 2395                 2400             


Asp Trp  Ser Pro Ile Leu Glu  Gly Phe Leu Lys Lys  Arg Ser Pro 
    2405                 2410                 2415             


Gln Glu  Ala Glu Ile Leu Arg  Gln Leu Tyr Thr Glu  Ser Phe Pro 
    2420                 2425                 2430             


Asp Leu  Tyr Arg Phe Cys Ile  Gln Asn Leu Glu Tyr  Lys Met Glu 
    2435                 2440                 2445             


Val Leu  Glu Ala Phe Val Ile  Thr Gln Ser Ile Asn  Met Leu Gln 
    2450                 2455                 2460             


Gly Leu  Ile Pro Leu Lys Glu  Gln Gly Gly Glu Val  Ser Gln Ala 
    2465                 2470                 2475             


His Leu  Gly Arg Leu Phe Val  Phe Ala Leu Leu Trp  Ser Ala Gly 
    2480                 2485                 2490             


Ala Ala  Leu Glu Leu Asp Gly  Arg Arg Arg Leu Glu  Leu Trp Leu 
    2495                 2500                 2505             


Arg Ser  Arg Pro Thr Gly Thr  Leu Glu Leu Pro Pro  Pro Ala Gly 
    2510                 2515                 2520             


Pro Gly  Asp Thr Ala Phe Asp  Tyr Tyr Val Ala Pro  Asp Gly Thr 
    2525                 2530                 2535             


Trp Thr  His Trp Asn Thr Arg  Thr Gln Glu Tyr Leu  Tyr Pro Ser 
    2540                 2545                 2550             


Asp Thr  Thr Pro Glu Tyr Gly  Ser Ile Leu Val Pro  Asn Val Asp 
    2555                 2560                 2565             


Asn Val  Arg Thr Asp Phe Leu  Ile Gln Thr Ile Ala  Lys Gln Gly 
    2570                 2575                 2580             


Lys Ala  Val Leu Leu Ile Gly  Glu Gln Gly Thr Ala  Lys Thr Val 
    2585                 2590                 2595             


Ile Ile  Lys Gly Phe Met Ser  Lys Tyr Asp Pro Glu  Cys His Met 
    2600                 2605                 2610             


Ile Lys  Ser Leu Asn Phe Ser  Ser Ala Thr Thr Pro  Leu Met Phe 
    2615                 2620                 2625             


Gln Arg  Thr Ile Glu Ser Tyr  Val Asp Lys Arg Met  Gly Thr Thr 
    2630                 2635                 2640             


Tyr Gly  Pro Pro Ala Gly Lys  Lys Met Thr Val Phe  Ile Asp Asp 
    2645                 2650                 2655             


Val Asn  Met Pro Ile Ile Asn  Glu Trp Gly Asp Gln  Val Thr Asn 
    2660                 2665                 2670             


Glu Ile  Val Arg Gln Leu Met  Glu Gln Asn Gly Phe  Tyr Asn Leu 
    2675                 2680                 2685             


Glu Lys  Pro Gly Glu Phe Thr  Ser Ile Val Asp Ile  Gln Phe Leu 
    2690                 2695                 2700             


Ala Ala  Met Ile His Pro Gly  Gly Gly Arg Asn Asp  Ile Pro Gln 
    2705                 2710                 2715             


Arg Leu  Lys Arg Gln Phe Ser  Ile Phe Asn Cys Thr  Leu Pro Ser 
    2720                 2725                 2730             


Glu Ala  Ser Val Asp Lys Ile  Phe Gly Val Ile Gly  Val Gly His 
    2735                 2740                 2745             


Tyr Cys  Thr Gln Arg Gly Phe  Ser Glu Glu Val Arg  Asp Ser Val 
    2750                 2755                 2760             


Thr Lys  Leu Val Pro Leu Thr  Arg Arg Leu Trp Gln  Met Thr Lys 
    2765                 2770                 2775             


Ile Lys  Met Leu Pro Thr Pro  Ala Lys Phe His Tyr  Val Phe Asn 
    2780                 2785                 2790             


Leu Arg  Asp Leu Ser Arg Val  Trp Gln Gly Met Leu  Asn Thr Thr 
    2795                 2800                 2805             


Ser Glu  Val Ile Lys Glu Pro  Asn Asp Leu Leu Lys  Leu Trp Lys 
    2810                 2815                 2820             


His Glu  Cys Lys Arg Val Ile  Ala Asp Arg Phe Thr  Val Ser Ser 
    2825                 2830                 2835             


Asp Val  Thr Trp Phe Asp Lys  Ala Leu Val Ser Leu  Val Glu Glu 
    2840                 2845                 2850             


Glu Phe  Gly Glu Glu Lys Lys  Leu Leu Val Asp Cys  Gly Ile Asp 
    2855                 2860                 2865             


Thr Tyr  Phe Val Asp Phe Leu  Arg Asp Ala Pro Glu  Ala Ala Gly 
    2870                 2875                 2880             


Glu Thr  Ser Glu Glu Ala Asp  Ala Glu Thr Pro Lys  Ile Tyr Glu 
    2885                 2890                 2895             


Pro Ile  Glu Ser Phe Ser His  Leu Lys Glu Arg Leu  Asn Met Phe 
    2900                 2905                 2910             


Leu Gln  Leu Tyr Asn Glu Ser  Ile Arg Gly Ala Gly  Met Asp Met 
    2915                 2920                 2925             


Val Phe  Phe Ala Asp Ala Met  Val His Leu Val Lys  Ile Ser Arg 
    2930                 2935                 2940             


Val Ile  Arg Thr Pro Gln Gly  Asn Ala Leu Leu Val  Gly Val Gly 
    2945                 2950                 2955             


Gly Ser  Gly Lys Gln Ser Leu  Thr Arg Leu Ala Ser  Phe Ile Ala 
    2960                 2965                 2970             


Gly Tyr  Val Ser Phe Gln Ile  Thr Leu Thr Arg Ser  Tyr Asn Thr 
    2975                 2980                 2985             


Ser Asn  Leu Met Glu Asp Leu  Lys Val Leu Tyr Arg  Thr Ala Gly 
    2990                 2995                 3000             


Gln Gln  Gly Lys Gly Ile Thr  Phe Ile Phe Thr Asp  Asn Glu Ile 
    3005                 3010                 3015             


Lys Asp  Glu Ser Phe Leu Glu  Tyr Met Asn Asn Val  Leu Ser Ser 
    3020                 3025                 3030             


Gly Glu  Val Ser Asn Leu Phe  Ala Arg Asp Glu Ile  Asp Glu Ile 
    3035                 3040                 3045             


Asn Ser  Asp Leu Ala Ser Val  Met Lys Lys Glu Phe  Pro Arg Cys 
    3050                 3055                 3060             


Leu Pro  Thr Asn Glu Asn Leu  His Asp Tyr Phe Met  Ser Arg Val 
    3065                 3070                 3075             


Arg Gln  Asn Leu His Ile Val  Leu Cys Phe Ser Pro  Val Gly Glu 
    3080                 3085                 3090             


Lys Phe  Arg Asn Arg Ala Leu  Lys Phe Pro Ala Leu  Ile Ser Gly 
    3095                 3100                 3105             


Cys Thr  Ile Asp Trp Phe Ser  Arg Trp Pro Lys Asp  Ala Leu Val 
    3110                 3115                 3120             


Ala Val  Ser Glu His Phe Leu  Thr Ser Tyr Asp Ile  Asp Cys Ser 
    3125                 3130                 3135             


Leu Glu  Ile Lys Lys Glu Val  Val Gln Cys Met Gly  Ser Phe Gln 
    3140                 3145                 3150             


Asp Gly  Val Ala Glu Lys Cys  Val Asp Tyr Phe Gln  Arg Phe Arg 
    3155                 3160                 3165             


Arg Ser  Thr His Val Thr Pro  Lys Ser Tyr Leu Ser  Phe Ile Gln 
    3170                 3175                 3180             


Gly Tyr  Lys Phe Ile Tyr Gly  Glu Lys His Val Glu  Val Arg Thr 
    3185                 3190                 3195             


Leu Ala  Asn Arg Met Asn Thr  Gly Leu Glu Lys Leu  Lys Glu Ala 
    3200                 3205                 3210             


Ser Glu  Ser Val Ala Ala Leu  Ser Lys Glu Leu Glu  Ala Lys Glu 
    3215                 3220                 3225             


Lys Glu  Leu Gln Val Ala Asn  Asp Lys Ala Asp Met  Val Leu Lys 
    3230                 3235                 3240             


Glu Val  Thr Met Lys Ala Gln  Ala Ala Glu Lys Val  Lys Ala Glu 
    3245                 3250                 3255             


Val Gln  Lys Val Lys Asp Arg  Ala Gln Ala Ile Val  Asp Ser Ile 
    3260                 3265                 3270             


Ser Lys  Asp Lys Ala Ile Ala  Glu Glu Lys Leu Glu  Ala Ala Lys 
    3275                 3280                 3285             


Pro Ala  Leu Glu Glu Ala Glu  Ala Ala Leu Gln Thr  Ile Arg Pro 
    3290                 3295                 3300             


Ser Asp  Ile Ala Thr Val Arg  Thr Leu Gly Arg Pro  Pro His Leu 
    3305                 3310                 3315             


Ile Met  Arg Ile Met Asp Cys  Val Leu Leu Leu Phe  Gln Arg Lys 
    3320                 3325                 3330             


Val Ser  Ala Val Lys Ile Asp  Leu Glu Lys Ser Cys  Thr Met Pro 
    3335                 3340                 3345             


Ser Trp  Gln Glu Ser Leu Lys  Leu Met Thr Ala Gly  Asn Phe Leu 
    3350                 3355                 3360             


Gln Asn  Leu Gln Gln Phe Pro  Lys Asp Thr Ile Asn  Glu Glu Val 
    3365                 3370                 3375             


Ile Glu  Phe Leu Ser Pro Tyr  Phe Glu Met Pro Asp  Tyr Asn Ile 
    3380                 3385                 3390             


Glu Thr  Ala Lys Arg Val Cys  Gly Asn Val Ala Gly  Leu Cys Ser 
    3395                 3400                 3405             


Trp Thr  Lys Ala Met Ala Ser  Phe Phe Ser Ile Asn  Lys Glu Val 
    3410                 3415                 3420             


Leu Pro  Leu Lys Ala Asn Leu  Val Val Gln Glu Asn  Arg His Leu 
    3425                 3430                 3435             


Leu Ala  Met Gln Asp Leu Gln  Lys Ala Gln Ala Glu  Leu Asp Asp 
    3440                 3445                 3450             


Lys Gln  Ala Glu Leu Asp Val  Val Gln Ala Glu Tyr  Glu Gln Ala 
    3455                 3460                 3465             


Met Thr  Glu Lys Gln Thr Leu  Leu Glu Asp Ala Glu  Arg Cys Arg 
    3470                 3475                 3480             


His Lys  Met Gln Thr Ala Ser  Thr Leu Ile Ser Gly  Leu Ala Gly 
    3485                 3490                 3495             


Glu Lys  Glu Arg Trp Thr Glu  Gln Ser Gln Glu Phe  Ala Ala Gln 
    3500                 3505                 3510             


Thr Lys  Arg Leu Val Gly Asp  Val Leu Leu Ala Thr  Ala Phe Leu 
    3515                 3520                 3525             


Ser Tyr  Ser Gly Pro Phe Asn  Gln Glu Phe Arg Asp  Leu Leu Leu 
    3530                 3535                 3540             


Asn Asp  Trp Arg Lys Glu Met  Lys Ala Arg Lys Ile  Pro Phe Gly 
    3545                 3550                 3555             


Lys Asn  Leu Asn Leu Ser Glu  Met Leu Ile Asp Ala  Pro Thr Ile 
    3560                 3565                 3570             


Ser Glu  Trp Asn Leu Gln Gly  Leu Pro Asn Asp Asp  Leu Ser Ile 
    3575                 3580                 3585             


Gln Asn  Gly Ile Ile Val Thr  Lys Ala Ser Arg Tyr  Pro Leu Leu 
    3590                 3595                 3600             


Ile Asp  Pro Gln Thr Gln Gly  Lys Ile Trp Ile Lys  Asn Lys Glu 
    3605                 3610                 3615             


Ser Arg  Asn Glu Leu Gln Ile  Thr Ser Leu Asn His  Lys Tyr Phe 
    3620                 3625                 3630             


Arg Asn  His Leu Glu Asp Ser  Leu Ser Leu Gly Arg  Pro Leu Leu 
    3635                 3640                 3645             


Ile Glu  Asp Val Gly Glu Glu  Leu Asp Pro Ala Leu  Asp Asn Val 
    3650                 3655                 3660             


Leu Glu  Arg Asn Phe Ile Lys  Thr Gly Ser Thr Phe  Lys Val Lys 
    3665                 3670                 3675             


Val Gly  Asp Lys Glu Val Asp  Val Leu Asp Gly Phe  Arg Leu Tyr 
    3680                 3685                 3690             


Ile Thr  Thr Lys Leu Pro Asn  Pro Ala Tyr Thr Pro  Glu Ile Ser 
    3695                 3700                 3705             


Ala Arg  Thr Ser Ile Ile Asp  Phe Thr Val Thr Met  Lys Gly Leu 
    3710                 3715                 3720             


Glu Asp  Gln Leu Leu Gly Arg  Val Ile Leu Thr Glu  Lys Gln Glu 
    3725                 3730                 3735             


Leu Glu  Lys Glu Arg Thr His  Leu Met Glu Asp Val  Thr Ala Asn 
    3740                 3745                 3750             


Lys Arg  Arg Met Lys Glu Leu  Glu Asp Asn Leu Leu  Tyr Arg Leu 
    3755                 3760                 3765             


Thr Ser  Thr Gln Gly Ser Leu  Val Glu Asp Glu Ser  Leu Ile Val 
    3770                 3775                 3780             


Val Leu  Ser Asn Thr Lys Arg  Thr Ala Glu Glu Val  Thr Gln Lys 
    3785                 3790                 3795             


Leu Glu  Ile Ser Ala Glu Thr  Glu Val Gln Ile Asn  Ser Ala Arg 
    3800                 3805                 3810             


Glu Glu  Tyr Arg Pro Val Ala  Thr Arg Gly Ser Ile  Leu Tyr Phe 
    3815                 3820                 3825             


Leu Ile  Thr Glu Met Arg Leu  Val Asn Glu Met Tyr  Gln Thr Ser 
    3830                 3835                 3840             


Leu Arg  Gln Phe Leu Gly Leu  Phe Asp Leu Ser Leu  Ala Arg Ser 
    3845                 3850                 3855             


Val Lys  Ser Pro Ile Thr Ser  Lys Arg Ile Ala Asn  Ile Ile Glu 
    3860                 3865                 3870             


His Met  Thr Tyr Glu Val Tyr  Lys Tyr Ala Ala Arg  Gly Leu Tyr 
    3875                 3880                 3885             


Glu Glu  His Lys Phe Leu Phe  Thr Leu Leu Leu Thr  Leu Lys Ile 
    3890                 3895                 3900             


Asp Ile  Gln Arg Asn Arg Val  Lys His Glu Glu Phe  Leu Thr Leu 
    3905                 3910                 3915             


Ile Lys  Gly Gly Ala Ser Leu  Asp Leu Lys Ala Cys  Pro Pro Lys 
    3920                 3925                 3930             


Pro Ser  Lys Trp Ile Leu Asp  Ile Thr Trp Leu Asn  Leu Val Glu 
    3935                 3940                 3945             


Leu Ser  Lys Leu Arg Gln Phe  Ser Asp Val Leu Asp  Gln Ile Ser 
    3950                 3955                 3960             


Arg Asn  Glu Lys Met Trp Lys  Ile Trp Phe Asp Lys  Glu Asn Pro 
    3965                 3970                 3975             


Glu Glu  Glu Pro Leu Pro Asn  Ala Tyr Asp Lys Ser  Leu Asp Cys 
    3980                 3985                 3990             


Phe Arg  Arg Leu Leu Leu Ile  Arg Ser Trp Cys Pro  Asp Arg Thr 
    3995                 4000                 4005             


Ile Ala  Gln Ala Arg Lys Tyr  Ile Val Asp Ser Met  Gly Glu Lys 
    4010                 4015                 4020             


Tyr Ala  Glu Gly Val Ile Leu  Asp Leu Glu Lys Thr  Trp Glu Glu 
    4025                 4030                 4035             


Ser Asp  Pro Arg Thr Pro Leu  Ile Cys Leu Leu Ser  Met Gly Ser 
    4040                 4045                 4050             


Asp Pro  Thr Asp Ser Ile Ile  Ala Leu Gly Lys Arg  Leu Lys Ile 
    4055                 4060                 4065             


Glu Thr  Arg Tyr Val Ser Met  Gly Gln Gly Gln Glu  Val His Ala 
    4070                 4075                 4080             


Arg Lys  Leu Leu Gln Gln Thr  Met Ala Asn Gly Gly  Trp Ala Leu 
    4085                 4090                 4095             


Leu Gln  Asn Cys His Leu Gly  Leu Asp Phe Met Asp  Glu Leu Met 
    4100                 4105                 4110             


Asp Ile  Ile Ile Glu Thr Glu  Leu Val His Asp Ala  Phe Arg Leu 
    4115                 4120                 4125             


Trp Met  Thr Thr Glu Ala His  Lys Gln Phe Pro Ile  Thr Leu Leu 
    4130                 4135                 4140             


Gln Met  Ser Ile Lys Phe Ala  Asn Asp Pro Pro Gln  Gly Leu Arg 
    4145                 4150                 4155             


Ala Gly  Leu Lys Arg Thr Tyr  Ser Gly Val Ser Gln  Asp Leu Leu 
    4160                 4165                 4170             


Asp Val  Ser Ser Gly Ser Gln  Trp Lys Pro Met Leu  Tyr Ala Val 
    4175                 4180                 4185             


Ala Phe  Leu His Ser Thr Val  Gln Glu Arg Arg Lys  Phe Gly Ala 
    4190                 4195                 4200             


Leu Gly  Trp Asn Ile Pro Tyr  Glu Phe Asn Gln Ala  Asp Phe Asn 
    4205                 4210                 4215             


Ala Thr  Val Gln Phe Ile Gln  Asn His Leu Asp Asp  Met Asp Val 
    4220                 4225                 4230             


Lys Lys  Gly Val Ser Trp Thr  Thr Ile Arg Tyr Met  Ile Gly Glu 
    4235                 4240                 4245             


Ile Gln  Tyr Gly Gly Arg Val  Thr Asp Asp Tyr Asp  Lys Arg Leu 
    4250                 4255                 4260             


Leu Asn  Thr Phe Ala Lys Val  Trp Phe Ser Glu Asn  Met Phe Gly 
    4265                 4270                 4275             


Pro Asp  Phe Ser Phe Tyr Gln  Gly Tyr Asn Ile Pro  Lys Cys Ser 
    4280                 4285                 4290             


Thr Val  Asp Asn Tyr Leu Gln  Tyr Ile Gln Ser Leu  Pro Ala Tyr 
    4295                 4300                 4305             


Asp Ser  Pro Glu Val Phe Gly  Leu His Pro Asn Ala  Asp Ile Thr 
    4310                 4315                 4320             


Tyr Gln  Ser Lys Leu Ala Lys  Asp Val Leu Asp Thr  Ile Leu Gly 
    4325                 4330                 4335             


Ile Gln  Pro Lys Asp Thr Ser  Gly Gly Gly Asp Glu  Thr Arg Glu 
    4340                 4345                 4350             


Ala Val  Val Ala Arg Leu Ala  Asp Asp Met Leu Glu  Lys Leu Pro 
    4355                 4360                 4365             


Pro Asp  Tyr Val Pro Phe Glu  Val Lys Glu Arg Leu  Gln Lys Met 
    4370                 4375                 4380             


Gly Pro  Phe Gln Pro Met Asn  Ile Phe Leu Arg Gln  Glu Ile Asp 
    4385                 4390                 4395             


Arg Met  Gln Arg Val Leu Ser  Leu Val Arg Ser Thr  Leu Thr Glu 
    4400                 4405                 4410             


Leu Lys  Leu Ala Ile Asp Gly  Thr Ile Ile Met Ser  Glu Asn Leu 
    4415                 4420                 4425             


Arg Asp  Ala Leu Asp Cys Met  Phe Asp Ala Arg Ile  Pro Ala Trp 
    4430                 4435                 4440             


Trp Lys  Lys Ala Ser Trp Ile  Ser Ser Thr Leu Gly  Phe Trp Phe 
    4445                 4450                 4455             


Thr Glu  Leu Ile Glu Arg Asn  Ser Gln Phe Thr Ser  Trp Val Phe 
    4460                 4465                 4470             


Asn Gly  Arg Pro His Cys Phe  Trp Met Thr Gly Phe  Phe Asn Pro 
    4475                 4480                 4485             


Gln Gly  Phe Leu Thr Ala Met  Arg Gln Glu Ile Thr  Arg Ala Asn 
    4490                 4495                 4500             


Lys Gly  Trp Ala Leu Asp Asn  Met Val Leu Cys Asn  Glu Val Thr 
    4505                 4510                 4515             


Lys Trp  Met Lys Asp Asp Ile  Ser Ala Pro Pro Thr  Glu Gly Val 
    4520                 4525                 4530             


Tyr Val  Tyr Gly Leu Tyr Leu  Glu Gly Ala Gly Trp  Asp Lys Arg 
    4535                 4540                 4545             


Asn Met  Lys Leu Ile Glu Ser  Lys Pro Lys Val Leu  Phe Glu Leu 
    4550                 4555                 4560             


Met Pro  Val Ile Arg Ile Tyr  Ala Glu Asn Asn Thr  Leu Arg Asp 
    4565                 4570                 4575             


Pro Arg  Phe Tyr Ser Cys Pro  Ile Tyr Lys Lys Pro  Val Arg Thr 
    4580                 4585                 4590             


Asp Leu  Asn Tyr Ile Ala Ala  Val Asp Leu Arg Thr  Ala Gln Thr 
    4595                 4600                 4605             


Pro Glu  His Trp Val Leu Arg  Gly Val Ala Leu Leu  Cys Asp Val 
    4610                 4615                 4620             


Lys 
    


<210>  141
<211>  781
<212>  PRT
<213>  homo sapiens

<400>  141

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  142
<211>  2177
<212>  PRT
<213>  homo sapiens

<400>  142

Met Glu Glu Ile Leu Arg Lys Leu Gln Lys Glu Ala Ser Gly Ser Lys 
1               5                   10                  15      


Tyr Lys Ala Ile Lys Glu Ser Cys Thr Trp Ala Leu Glu Thr Leu Gly 
            20                  25                  30          


Gly Leu Asp Thr Ile Val Lys Ile Pro Pro His Val Leu Arg Glu Lys 
        35                  40                  45              


Cys Leu Leu Pro Leu Gln Leu Ala Leu Glu Ser Lys Asn Val Lys Leu 
    50                  55                  60                  


Ala Gln His Ala Leu Ala Gly Met Gln Lys Leu Leu Ser Glu Glu Arg 
65                  70                  75                  80  


Phe Val Ser Met Glu Thr Asp Ser Asp Glu Lys Gln Leu Leu Asn Gln 
                85                  90                  95      


Ile Leu Asn Ala Val Lys Val Thr Pro Ser Leu Asn Glu Asp Leu Gln 
            100                 105                 110         


Val Glu Val Met Lys Val Leu Leu Cys Ile Thr Tyr Thr Pro Thr Phe 
        115                 120                 125             


Asp Leu Asn Gly Ser Ala Val Leu Lys Ile Ala Glu Val Cys Ile Glu 
    130                 135                 140                 


Thr Tyr Ile Ser Ser Cys His Gln Arg Ser Ile Asn Thr Ala Val Arg 
145                 150                 155                 160 


Ala Thr Leu Ser Gln Met Leu Ser Asp Leu Thr Leu Gln Leu Arg Gln 
                165                 170                 175     


Arg Gln Glu Asn Thr Ile Ile Glu Asn Pro Asp Val Pro Gln Asp Phe 
            180                 185                 190         


Gly Asn Gln Gly Ser Thr Val Glu Ser Leu Cys Asp Asp Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu Cys Glu Lys Leu Gln Ala Ala Ile Asn Asp Ser 
    210                 215                 220                 


Gln Gln Leu Gln Leu Leu Tyr Leu Glu Cys Ile Leu Ser Val Leu Ser 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Met His Leu His Arg Arg Phe Thr Asp Leu Ile 
                245                 250                 255     


Trp Lys Asn Leu Cys Pro Ala Leu Ile Val Ile Leu Gly Asn Pro Ile 
            260                 265                 270         


His Asp Lys Thr Ile Thr Ser Ala His Thr Ser Ser Thr Ser Thr Ser 
        275                 280                 285             


Leu Glu Ser Asp Ser Ala Ser Pro Gly Val Ser Asp His Gly Arg Gly 
    290                 295                 300                 


Ser Gly Cys Ser Cys Thr Ala Pro Ala Leu Ser Gly Pro Val Ala Arg 
305                 310                 315                 320 


Thr Ile Tyr Tyr Ile Ala Ala Glu Leu Val Arg Leu Val Gly Ser Val 
                325                 330                 335     


Asp Ser Met Lys Pro Val Leu Gln Ser Leu Tyr His Arg Val Leu Leu 
            340                 345                 350         


Tyr Pro Pro Pro Gln His Arg Val Glu Ala Ile Lys Ile Met Lys Glu 
        355                 360                 365             


Ile Leu Gly Ser Pro Gln Arg Leu Cys Asp Leu Ala Gly Pro Ser Ser 
    370                 375                 380                 


Thr Glu Ser Glu Ser Arg Lys Arg Ser Ile Ser Lys Arg Lys Ser His 
385                 390                 395                 400 


Leu Asp Leu Leu Lys Leu Ile Met Asp Gly Met Thr Glu Ala Cys Ile 
                405                 410                 415     


Lys Gly Gly Ile Glu Ala Cys Tyr Ala Ala Val Ser Cys Val Cys Thr 
            420                 425                 430         


Leu Leu Gly Ala Leu Asp Glu Leu Ser Gln Gly Lys Gly Leu Ser Glu 
        435                 440                 445             


Gly Gln Val Gln Leu Leu Leu Leu Arg Leu Glu Glu Leu Lys Asp Gly 
    450                 455                 460                 


Ala Glu Trp Ser Arg Asp Ser Met Glu Ile Asn Glu Ala Asp Phe Arg 
465                 470                 475                 480 


Trp Gln Arg Arg Val Leu Ser Ser Glu His Thr Pro Trp Glu Ser Gly 
                485                 490                 495     


Asn Glu Arg Ser Leu Asp Ile Ser Ile Ser Val Thr Thr Asp Thr Gly 
            500                 505                 510         


Gln Thr Thr Leu Glu Gly Glu Leu Gly Gln Thr Thr Pro Glu Asp His 
        515                 520                 525             


Ser Gly Asn His Lys Asn Ser Leu Lys Ser Pro Ala Ile Pro Glu Gly 
    530                 535                 540                 


Lys Glu Thr Leu Ser Lys Val Leu Glu Thr Glu Ala Val Asp Gln Pro 
545                 550                 555                 560 


Asp Val Val Gln Arg Ser His Thr Val Pro Tyr Pro Asp Ile Thr Asn 
                565                 570                 575     


Phe Leu Ser Val Asp Cys Arg Thr Arg Ser Tyr Gly Ser Arg Tyr Ser 
            580                 585                 590         


Glu Ser Asn Phe Ser Val Asp Asp Gln Asp Leu Ser Arg Thr Glu Phe 
        595                 600                 605             


Asp Ser Cys Asp Gln Tyr Ser Met Ala Ala Glu Lys Asp Ser Gly Arg 
    610                 615                 620                 


Ser Asp Val Ser Asp Ile Gly Ser Asp Asn Cys Ser Leu Ala Asp Glu 
625                 630                 635                 640 


Glu Gln Thr Pro Arg Asp Cys Leu Gly His Arg Ser Leu Arg Thr Ala 
                645                 650                 655     


Ala Leu Ser Leu Lys Leu Leu Lys Asn Gln Glu Ala Asp Gln His Ser 
            660                 665                 670         


Ala Arg Leu Phe Ile Gln Ser Leu Glu Gly Leu Leu Pro Arg Leu Leu 
        675                 680                 685             


Ser Leu Ser Asn Val Glu Glu Val Asp Thr Ala Leu Gln Asn Phe Ala 
    690                 695                 700                 


Ser Thr Phe Cys Ser Gly Met Met His Ser Pro Gly Phe Asp Gly Asn 
705                 710                 715                 720 


Ser Ser Leu Ser Phe Gln Met Leu Met Asn Ala Asp Ser Leu Tyr Thr 
                725                 730                 735     


Ala Ala His Cys Ala Leu Leu Leu Asn Leu Lys Leu Ser His Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Lys Arg Pro Thr Leu Ala Pro Gly Val Met Lys Asp Phe 
        755                 760                 765             


Met Lys Gln Val Gln Thr Ser Gly Val Leu Met Val Phe Ser Gln Ala 
    770                 775                 780                 


Trp Ile Glu Glu Leu Tyr His Gln Val Leu Asp Arg Asn Met Leu Gly 
785                 790                 795                 800 


Glu Ala Gly Tyr Trp Gly Ser Pro Glu Asp Asn Ser Leu Pro Leu Ile 
                805                 810                 815     


Thr Met Leu Thr Asp Ile Asp Gly Leu Glu Ser Ser Ala Ile Gly Gly 
            820                 825                 830         


Gln Leu Met Ala Ser Ala Ala Thr Glu Ser Pro Phe Ala Gln Ser Arg 
        835                 840                 845             


Arg Ile Asp Asp Ser Thr Val Ala Gly Val Ala Phe Ala Arg Tyr Ile 
    850                 855                 860                 


Leu Val Gly Cys Trp Lys Asn Leu Ile Asp Thr Leu Ser Thr Pro Leu 
865                 870                 875                 880 


Thr Gly Arg Met Ala Gly Ser Ser Lys Gly Leu Ala Phe Ile Leu Gly 
                885                 890                 895     


Ala Glu Gly Ile Lys Glu Gln Asn Gln Lys Glu Arg Asp Ala Ile Cys 
            900                 905                 910         


Met Ser Leu Asp Gly Leu Arg Lys Ala Ala Arg Leu Ser Cys Ala Leu 
        915                 920                 925             


Gly Val Ala Ala Asn Cys Ala Ser Ala Leu Ala Gln Met Ala Ala Ala 
    930                 935                 940                 


Ser Cys Val Gln Glu Glu Lys Glu Glu Arg Glu Ala Gln Glu Pro Ser 
945                 950                 955                 960 


Asp Ala Ile Thr Gln Val Lys Leu Lys Val Glu Gln Lys Leu Glu Gln 
                965                 970                 975     


Ile Gly Lys Val Gln Gly Val Trp Leu His Thr Ala His Val Leu Cys 
            980                 985                 990         


Met Glu Ala Ile Leu Ser Val Gly  Leu Glu Met Gly Ser  His Asn Pro 
        995                 1000                 1005             


Asp Cys  Trp Pro His Val Phe  Arg Val Cys Glu Tyr  Val Gly Thr 
    1010                 1015                 1020             


Leu Glu  His Asn His Phe Ser  Asp Gly Ala Ser Gln  Pro Pro Leu 
    1025                 1030                 1035             


Thr Ile  Ser Gln Pro Gln Lys  Ala Thr Gly Ser Ala  Gly Leu Leu 
    1040                 1045                 1050             


Gly Asp  Pro Glu Cys Glu Gly  Ser Pro Pro Glu His  Ser Pro Glu 
    1055                 1060                 1065             


Gln Gly  Arg Ser Leu Ser Thr  Ala Pro Val Val Gln  Pro Leu Ser 
    1070                 1075                 1080             


Ile Gln  Asp Leu Val Arg Glu  Gly Ser Arg Gly Arg  Ala Ser Asp 
    1085                 1090                 1095             


Phe Arg  Gly Gly Ser Leu Met  Ser Gly Ser Ser Ala  Ala Lys Val 
    1100                 1105                 1110             


Val Leu  Thr Leu Ser Thr Gln  Ala Asp Arg Leu Phe  Glu Asp Ala 
    1115                 1120                 1125             


Thr Asp  Lys Leu Asn Leu Met  Ala Leu Gly Gly Phe  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Lys  Lys Ala Ser Gln Ser  Gln Leu Phe His Ser  Val Thr Asp 
    1145                 1150                 1155             


Thr Val  Asp Tyr Ser Leu Ala  Met Pro Gly Glu Val  Lys Ser Thr 
    1160                 1165                 1170             


Gln Asp  Arg Lys Ser Ala Leu  His Leu Phe Arg Leu  Gly Asn Ala 
    1175                 1180                 1185             


Met Leu  Arg Ile Val Arg Ser  Lys Ala Arg Pro Leu  Leu His Val 
    1190                 1195                 1200             


Met Arg  Cys Trp Ser Leu Val  Ala Pro His Leu Val  Glu Ala Ala 
    1205                 1210                 1215             


Cys His  Lys Glu Arg His Val  Ser Gln Lys Ala Val  Ser Phe Ile 
    1220                 1225                 1230             


His Asp  Ile Leu Thr Glu Val  Leu Thr Asp Trp Asn  Glu Pro Pro 
    1235                 1240                 1245             


His Phe  His Phe Asn Glu Ala  Leu Phe Arg Pro Phe  Glu Arg Ile 
    1250                 1255                 1260             


Met Gln  Leu Glu Leu Cys Asp  Glu Asp Val Gln Asp  Gln Val Val 
    1265                 1270                 1275             


Thr Ser  Ile Gly Glu Leu Val  Glu Val Cys Ser Thr  Gln Ile Gln 
    1280                 1285                 1290             


Ser Gly  Trp Arg Pro Leu Phe  Ser Ala Leu Glu Thr  Val His Gly 
    1295                 1300                 1305             


Gly Asn  Lys Ser Glu Met Lys  Glu Tyr Leu Val Gly  Asp Tyr Ser 
    1310                 1315                 1320             


Met Gly  Lys Gly Gln Ala Pro  Val Phe Asp Val Phe  Glu Ala Phe 
    1325                 1330                 1335             


Leu Asn  Thr Asp Asn Ile Gln  Val Phe Ala Asn Ala  Ala Thr Ser 
    1340                 1345                 1350             


Tyr Ile  Met Cys Leu Met Lys  Phe Val Lys Gly Leu  Gly Glu Val 
    1355                 1360                 1365             


Asp Cys  Lys Glu Ile Gly Asp  Cys Ala Pro Ala Pro  Gly Ala Pro 
    1370                 1375                 1380             


Ser Thr  Asp Leu Cys Leu Pro  Ala Leu Asp Tyr Leu  Arg Arg Cys 
    1385                 1390                 1395             


Ser Gln  Leu Leu Ala Lys Ile  Tyr Lys Met Pro Leu  Lys Pro Ile 
    1400                 1405                 1410             


Phe Leu  Ser Gly Arg Leu Ala  Gly Leu Pro Arg Arg  Leu Gln Glu 
    1415                 1420                 1425             


Gln Ser  Ala Ser Ser Glu Asp  Gly Ile Glu Ser Val  Leu Ser Asp 
    1430                 1435                 1440             


Phe Asp  Asp Asp Thr Gly Leu  Ile Glu Val Trp Ile  Ile Leu Leu 
    1445                 1450                 1455             


Glu Gln  Leu Thr Ala Ala Val  Ser Asn Cys Pro Arg  Gln His Gln 
    1460                 1465                 1470             


Pro Pro  Thr Leu Asp Leu Leu  Phe Glu Leu Leu Arg  Asp Val Thr 
    1475                 1480                 1485             


Lys Thr  Pro Gly Pro Gly Phe  Gly Ile Tyr Ala Val  Val His Leu 
    1490                 1495                 1500             


Leu Leu  Pro Val Met Ser Val  Trp Leu Arg Arg Ser  His Lys Asp 
    1505                 1510                 1515             


His Ser  Tyr Trp Asp Met Ala  Ser Ala Asn Phe Lys  His Ala Ile 
    1520                 1525                 1530             


Gly Leu  Ser Cys Glu Leu Val  Val Glu His Ile Gln  Ser Phe Leu 
    1535                 1540                 1545             


His Ser  Asp Ile Arg Tyr Glu  Ser Met Ile Asn Thr  Met Leu Lys 
    1550                 1555                 1560             


Asp Leu  Phe Glu Leu Leu Val  Ala Cys Val Ala Lys  Pro Thr Glu 
    1565                 1570                 1575             


Thr Ile  Ser Arg Val Gly Cys  Ser Cys Ile Arg Tyr  Val Leu Val 
    1580                 1585                 1590             


Thr Ala  Gly Pro Val Phe Thr  Glu Glu Met Trp Arg  Leu Ala Cys 
    1595                 1600                 1605             


Cys Ala  Leu Gln Asp Ala Phe  Ser Ala Thr Leu Lys  Pro Val Lys 
    1610                 1615                 1620             


Asp Leu  Leu Gly Cys Phe His  Ser Gly Thr Glu Ser  Phe Ser Gly 
    1625                 1630                 1635             


Glu Gly  Cys Gln Val Arg Val  Ala Ala Pro Ser Ser  Ser Pro Ser 
    1640                 1645                 1650             


Ala Glu  Ala Glu Tyr Trp Arg  Ile Arg Ala Met Ala  Gln Gln Val 
    1655                 1660                 1665             


Phe Met  Leu Asp Thr Gln Cys  Ser Pro Lys Thr Pro  Asn Asn Phe 
    1670                 1675                 1680             


Asp His  Ala Gln Ser Cys Gln  Leu Ile Ile Glu Leu  Pro Pro Asp 
    1685                 1690                 1695             


Glu Lys  Pro Asn Gly His Thr  Lys Lys Ser Val Ser  Phe Arg Glu 
    1700                 1705                 1710             


Ile Val  Val Ser Leu Leu Ser  His Gln Val Leu Leu  Gln Asn Leu 
    1715                 1720                 1725             


Tyr Asp  Ile Leu Leu Glu Glu  Phe Val Lys Gly Pro  Ser Pro Gly 
    1730                 1735                 1740             


Glu Glu  Lys Thr Ile Gln Val  Pro Glu Ala Lys Leu  Ala Gly Phe 
    1745                 1750                 1755             


Leu Arg  Tyr Ile Ser Met Gln  Asn Leu Ala Val Ile  Phe Asp Leu 
    1760                 1765                 1770             


Leu Leu  Asp Ser Tyr Arg Thr  Ala Arg Glu Phe Asp  Thr Ser Pro 
    1775                 1780                 1785             


Gly Leu  Lys Cys Leu Leu Lys  Lys Val Ser Gly Ile  Gly Gly Ala 
    1790                 1795                 1800             


Ala Asn  Leu Tyr Arg Gln Ser  Ala Met Ser Phe Asn  Ile Tyr Phe 
    1805                 1810                 1815             


His Ala  Leu Val Cys Ala Val  Leu Thr Asn Gln Glu  Thr Ile Thr 
    1820                 1825                 1830             


Ala Glu  Gln Val Lys Lys Val  Leu Phe Glu Asp Asp  Glu Arg Ser 
    1835                 1840                 1845             


Thr Asp  Ser Ser Gln Gln Cys  Ser Ser Glu Asp Glu  Asp Ile Phe 
    1850                 1855                 1860             


Glu Glu  Thr Ala Gln Val Ser  Pro Pro Arg Gly Lys  Glu Lys Arg 
    1865                 1870                 1875             


Gln Trp  Arg Ala Arg Met Pro  Leu Leu Ser Val Gln  Pro Val Ser 
    1880                 1885                 1890             


Asn Ala  Asp Trp Val Trp Leu  Val Lys Arg Leu His  Lys Leu Cys 
    1895                 1900                 1905             


Met Glu  Leu Cys Asn Asn Tyr  Ile Gln Met His Leu  Asp Leu Glu 
    1910                 1915                 1920             


Asn Cys  Met Glu Glu Pro Pro  Ile Phe Lys Gly Asp  Pro Phe Phe 
    1925                 1930                 1935             


Ile Leu  Pro Ser Phe Gln Ser  Glu Ser Ser Thr Pro  Ser Thr Gly 
    1940                 1945                 1950             


Gly Phe  Ser Gly Lys Glu Thr  Pro Ser Glu Asp Asp  Arg Ser Gln 
    1955                 1960                 1965             


Ser Arg  Glu His Met Gly Glu  Ser Leu Ser Leu Lys  Ala Gly Gly 
    1970                 1975                 1980             


Gly Asp  Leu Leu Leu Pro Pro  Ser Pro Lys Val Glu  Lys Lys Asp 
    1985                 1990                 1995             


Pro Ser  Arg Lys Lys Glu Trp  Trp Glu Asn Ala Gly  Asn Lys Ile 
    2000                 2005                 2010             


Tyr Thr  Met Ala Ala Asp Lys  Thr Ile Ser Lys Leu  Met Thr Glu 
    2015                 2020                 2025             


Tyr Lys  Lys Arg Lys Gln Gln  His Asn Leu Ser Ala  Phe Pro Lys 
    2030                 2035                 2040             


Glu Val  Lys Val Glu Lys Lys  Gly Glu Pro Leu Gly  Pro Arg Gly 
    2045                 2050                 2055             


Gln Asp  Ser Pro Leu Leu Gln  Arg Pro Gln His Leu  Met Asp Gln 
    2060                 2065                 2070             


Gly Gln  Met Arg His Ser Phe  Ser Ala Gly Pro Glu  Leu Leu Arg 
    2075                 2080                 2085             


Gln Asp  Lys Arg Pro Arg Ser  Gly Ser Thr Gly Ser  Ser Leu Ser 
    2090                 2095                 2100             


Val Ser  Val Arg Asp Ala Glu  Ala Gln Ile Gln Ala  Trp Thr Asn 
    2105                 2110                 2115             


Met Val  Leu Thr Val Leu Asn  Gln Ile Gln Ile Leu  Pro Asp Gln 
    2120                 2125                 2130             


Thr Phe  Thr Ala Leu Gln Pro  Ala Val Phe Pro Cys  Ile Ser Gln 
    2135                 2140                 2145             


Leu Thr  Cys His Val Thr Asp  Ile Arg Val Arg Gln  Ala Val Arg 
    2150                 2155                 2160             


Glu Trp  Leu Gly Arg Val Gly  Arg Val Tyr Asp Ile  Ile Val 
    2165                 2170                 2175         


<210>  143
<211>  188
<212>  PRT
<213>  homo sapiens

<400>  143

Met Ala Glu Thr Ser Leu Pro Glu Leu Gly Gly Glu Asp Lys Ala Thr 
1               5                   10                  15      


Pro Cys Pro Ser Ile Leu Glu Leu Glu Glu Leu Leu Arg Ala Gly Lys 
            20                  25                  30          


Ser Ser Cys Ser Arg Val Asp Glu Val Trp Pro Asn Leu Phe Ile Gly 
        35                  40                  45              


Asp Ala Ala Thr Ala Asn Asn Arg Phe Glu Leu Trp Lys Leu Gly Ile 
    50                  55                  60                  


Thr His Val Leu Asn Ala Ala His Arg Gly Leu Tyr Cys Gln Gly Gly 
65                  70                  75                  80  


Pro Asp Phe Tyr Gly Ser Ser Val Ser Tyr Leu Gly Val Pro Ala His 
                85                  90                  95      


Asp Leu Pro Asp Phe Asp Ile Ser Ala Tyr Phe Ser Ser Ala Ala Asp 
            100                 105                 110         


Phe Ile His Arg Ala Leu Asn Thr Pro Gly Ala Lys Val Leu Val His 
        115                 120                 125             


Cys Val Val Gly Val Ser Arg Ser Ala Thr Leu Val Leu Ala Tyr Leu 
    130                 135                 140                 


Met Leu His Gln Arg Leu Ser Leu Arg Gln Ala Val Ile Thr Val Arg 
145                 150                 155                 160 


Gln His Arg Trp Val Phe Pro Asn Arg Gly Phe Leu His Gln Leu Cys 
                165                 170                 175     


Arg Leu Asp Gln Gln Leu Arg Gly Ala Gly Gln Ser 
            180                 185             


<210>  144
<211>  1380
<212>  PRT
<213>  homo sapiens

<400>  144

Met Ala Ser Gly Arg Asp Glu Arg Pro Pro Trp Arg Leu Gly Arg Leu 
1               5                   10                  15      


Leu Leu Leu Met Cys Leu Leu Leu Leu Gly Ser Ser Ala Arg Ala Ala 
            20                  25                  30          


His Ile Lys Lys Ala Glu Ala Thr Thr Thr Thr Thr Ser Ala Gly Ala 
        35                  40                  45              


Glu Ala Ala Glu Gly Gln Phe Asp Arg Tyr Tyr His Glu Glu Glu Leu 
    50                  55                  60                  


Glu Ser Ala Leu Arg Glu Ala Ala Ala Ala Gly Leu Pro Gly Leu Ala 
65                  70                  75                  80  


Arg Leu Phe Ser Ile Gly Arg Ser Val Glu Gly Arg Pro Leu Trp Val 
                85                  90                  95      


Leu Arg Leu Thr Ala Gly Leu Gly Ser Leu Ile Pro Glu Gly Asp Ala 
            100                 105                 110         


Gly Pro Asp Ala Ala Gly Pro Asp Ala Ala Gly Pro Leu Leu Pro Gly 
        115                 120                 125             


Arg Pro Gln Val Lys Leu Val Gly Asn Met His Gly Asp Glu Thr Val 
    130                 135                 140                 


Ser Arg Gln Val Leu Ile Tyr Leu Ala Arg Glu Leu Ala Ala Gly Tyr 
145                 150                 155                 160 


Arg Arg Gly Asp Pro Arg Leu Val Arg Leu Leu Asn Thr Thr Asp Val 
                165                 170                 175     


Tyr Leu Leu Pro Ser Leu Asn Pro Asp Gly Phe Glu Arg Ala Arg Glu 
            180                 185                 190         


Gly Asp Cys Gly Phe Gly Asp Gly Gly Pro Ser Gly Ala Ser Gly Arg 
        195                 200                 205             


Asp Asn Ser Arg Gly Arg Asp Leu Asn Arg Ser Phe Pro Asp Gln Phe 
    210                 215                 220                 


Ser Thr Gly Glu Pro Pro Ala Leu Asp Glu Val Pro Glu Val Arg Ala 
225                 230                 235                 240 


Leu Ile Glu Trp Ile Arg Arg Asn Lys Phe Val Leu Ser Gly Asn Leu 
                245                 250                 255     


His Gly Gly Ser Val Val Ala Ser Tyr Pro Phe Asp Asp Ser Pro Glu 
            260                 265                 270         


His Lys Ala Thr Gly Ile Tyr Ser Lys Thr Ser Asp Asp Glu Val Phe 
        275                 280                 285             


Lys Tyr Leu Ala Lys Ala Tyr Ala Ser Asn His Pro Ile Met Lys Thr 
    290                 295                 300                 


Gly Glu Pro His Cys Pro Gly Asp Glu Asp Glu Thr Phe Lys Asp Gly 
305                 310                 315                 320 


Ile Thr Asn Gly Ala His Trp Tyr Asp Val Glu Gly Gly Met Gln Asp 
                325                 330                 335     


Tyr Asn Tyr Val Trp Ala Asn Cys Phe Glu Ile Thr Leu Glu Leu Ser 
            340                 345                 350         


Cys Cys Lys Tyr Pro Pro Ala Ser Gln Leu Arg Gln Glu Trp Glu Asn 
        355                 360                 365             


Asn Arg Glu Ser Leu Ile Thr Leu Ile Glu Lys Val His Ile Gly Val 
    370                 375                 380                 


Lys Gly Phe Val Lys Asp Ser Ile Thr Gly Ser Gly Leu Glu Asn Ala 
385                 390                 395                 400 


Thr Ile Ser Val Ala Gly Ile Asn His Asn Ile Thr Thr Gly Arg Phe 
                405                 410                 415     


Gly Asp Phe Tyr Arg Leu Leu Val Pro Gly Thr Tyr Asn Leu Thr Val 
            420                 425                 430         


Val Leu Thr Gly Tyr Met Pro Leu Thr Val Thr Asn Val Val Val Lys 
        435                 440                 445             


Glu Gly Pro Ala Thr Glu Val Asp Phe Ser Leu Arg Pro Thr Val Thr 
    450                 455                 460                 


Ser Val Ile Pro Asp Thr Thr Glu Ala Val Ser Thr Ala Ser Thr Val 
465                 470                 475                 480 


Ala Ile Pro Asn Ile Leu Ser Gly Thr Ser Ser Ser Tyr Gln Pro Ile 
                485                 490                 495     


Gln Pro Lys Asp Phe His His His His Phe Pro Asp Met Glu Ile Phe 
            500                 505                 510         


Leu Arg Arg Phe Ala Asn Glu Tyr Pro Asn Ile Thr Arg Leu Tyr Ser 
        515                 520                 525             


Leu Gly Lys Ser Val Glu Ser Arg Glu Leu Tyr Val Met Glu Ile Ser 
    530                 535                 540                 


Asp Asn Pro Gly Val His Glu Pro Gly Glu Pro Glu Phe Lys Tyr Ile 
545                 550                 555                 560 


Gly Asn Met His Gly Asn Glu Val Val Gly Arg Glu Leu Leu Leu Asn 
                565                 570                 575     


Leu Ile Glu Tyr Leu Cys Lys Asn Phe Gly Thr Asp Pro Glu Val Thr 
            580                 585                 590         


Asp Leu Val His Asn Thr Arg Ile His Leu Met Pro Ser Met Asn Pro 
        595                 600                 605             


Asp Gly Tyr Glu Lys Ser Gln Glu Gly Asp Ser Ile Ser Val Ile Gly 
    610                 615                 620                 


Arg Asn Asn Ser Asn Asn Phe Asp Leu Asn Arg Asn Phe Pro Asp Gln 
625                 630                 635                 640 


Phe Val Gln Ile Thr Asp Pro Thr Gln Pro Glu Thr Ile Ala Val Met 
                645                 650                 655     


Ser Trp Met Lys Ser Tyr Pro Phe Val Leu Ser Ala Asn Leu His Gly 
            660                 665                 670         


Gly Ser Leu Val Val Asn Tyr Pro Phe Asp Asp Asp Glu Gln Gly Leu 
        675                 680                 685             


Ala Thr Tyr Ser Lys Ser Pro Asp Asp Ala Val Phe Gln Gln Ile Ala 
    690                 695                 700                 


Leu Ser Tyr Ser Lys Glu Asn Ser Gln Met Phe Gln Gly Arg Pro Cys 
705                 710                 715                 720 


Lys Asn Met Tyr Pro Asn Glu Tyr Phe Pro His Gly Ile Thr Asn Gly 
                725                 730                 735     


Ala Ser Trp Tyr Asn Val Pro Gly Gly Met Gln Asp Trp Asn Tyr Leu 
            740                 745                 750         


Gln Thr Asn Cys Phe Glu Val Thr Ile Glu Leu Gly Cys Val Lys Tyr 
        755                 760                 765             


Pro Leu Glu Lys Glu Leu Pro Asn Phe Trp Glu Gln Asn Arg Arg Ser 
    770                 775                 780                 


Leu Ile Gln Phe Met Lys Gln Val His Gln Gly Val Arg Gly Phe Val 
785                 790                 795                 800 


Leu Asp Ala Thr Asp Gly Arg Gly Ile Leu Asn Ala Thr Ile Ser Val 
                805                 810                 815     


Ala Glu Ile Asn His Pro Val Thr Thr Tyr Lys Thr Gly Asp Tyr Trp 
            820                 825                 830         


Arg Leu Leu Val Pro Gly Thr Tyr Lys Ile Thr Ala Ser Ala Arg Gly 
        835                 840                 845             


Tyr Asn Pro Val Thr Lys Asn Val Thr Val Lys Ser Glu Gly Ala Ile 
    850                 855                 860                 


Gln Val Asn Phe Thr Leu Val Arg Ser Ser Thr Asp Ser Asn Asn Glu 
865                 870                 875                 880 


Ser Lys Lys Gly Lys Gly Ala Ser Ser Ser Thr Asn Asp Ala Ser Asp 
                885                 890                 895     


Pro Thr Thr Lys Glu Phe Glu Thr Leu Ile Lys Asp Leu Ser Ala Glu 
            900                 905                 910         


Asn Gly Leu Glu Ser Leu Met Leu Arg Ser Ser Ser Asn Leu Ala Leu 
        915                 920                 925             


Ala Leu Tyr Arg Tyr His Ser Tyr Lys Asp Leu Ser Glu Phe Leu Arg 
    930                 935                 940                 


Gly Leu Val Met Asn Tyr Pro His Ile Thr Asn Leu Thr Asn Leu Gly 
945                 950                 955                 960 


Gln Ser Thr Glu Tyr Arg His Ile Trp Ser Leu Glu Ile Ser Asn Lys 
                965                 970                 975     


Pro Asn Val Ser Glu Pro Glu Glu Pro Lys Ile Arg Phe Val Ala Gly 
            980                 985                 990         


Ile His Gly Asn Ala Pro Val Gly  Thr Glu Leu Leu Leu  Ala Leu Ala 
        995                 1000                 1005             


Glu Phe  Leu Cys Leu Asn Tyr  Lys Lys Asn Pro Ala  Val Thr Gln 
    1010                 1015                 1020             


Leu Val  Asp Arg Thr Arg Ile  Val Ile Val Pro Ser  Leu Asn Pro 
    1025                 1030                 1035             


Asp Gly  Arg Glu Arg Ala Gln  Glu Lys Asp Cys Thr  Ser Lys Ile 
    1040                 1045                 1050             


Gly Gln  Thr Asn Ala Arg Gly  Lys Asp Leu Asp Thr  Asp Phe Thr 
    1055                 1060                 1065             


Asn Asn  Ala Ser Gln Pro Glu  Thr Lys Ala Ile Ile  Glu Asn Leu 
    1070                 1075                 1080             


Ile Gln  Lys Gln Asp Phe Ser  Leu Ser Val Ala Leu  Asp Gly Gly 
    1085                 1090                 1095             


Ser Met  Leu Val Thr Tyr Pro  Tyr Asp Lys Pro Val  Gln Thr Val 
    1100                 1105                 1110             


Glu Asn  Lys Glu Thr Leu Lys  His Leu Ala Ser Leu  Tyr Ala Asn 
    1115                 1120                 1125             


Asn His  Pro Ser Met His Met  Gly Gln Pro Ser Cys  Pro Asn Lys 
    1130                 1135                 1140             


Ser Asp  Glu Asn Ile Pro Gly  Gly Val Met Arg Gly  Ala Glu Trp 
    1145                 1150                 1155             


His Ser  His Leu Gly Ser Met  Lys Asp Tyr Ser Val  Thr Tyr Gly 
    1160                 1165                 1170             


His Cys  Pro Glu Ile Thr Val  Tyr Thr Ser Cys Cys  Tyr Phe Pro 
    1175                 1180                 1185             


Ser Ala  Ala Arg Leu Pro Ser  Leu Trp Ala Asp Asn  Lys Arg Ser 
    1190                 1195                 1200             


Leu Leu  Ser Met Leu Val Glu  Val His Lys Gly Val  His Gly Phe 
    1205                 1210                 1215             


Val Lys  Asp Lys Thr Gly Lys  Pro Ile Ser Lys Ala  Val Ile Val 
    1220                 1225                 1230             


Leu Asn  Glu Gly Ile Lys Val  Gln Thr Lys Glu Gly  Gly Tyr Phe 
    1235                 1240                 1245             


His Val  Leu Leu Ala Pro Gly  Val His Asn Ile Ile  Ala Ile Ala 
    1250                 1255                 1260             


Asp Gly  Tyr Gln Gln Gln His  Ser Gln Val Phe Val  His His Asp 
    1265                 1270                 1275             


Ala Ala  Ser Ser Val Val Ile  Val Phe Asp Thr Asp  Asn Arg Ile 
    1280                 1285                 1290             


Phe Gly  Leu Pro Arg Glu Leu  Val Val Thr Val Ser  Gly Ala Thr 
    1295                 1300                 1305             


Met Ser  Ala Leu Ile Leu Thr  Ala Cys Ile Ile Trp  Cys Ile Cys 
    1310                 1315                 1320             


Ser Ile  Lys Ser Asn Arg His  Lys Asp Gly Phe His  Arg Leu Arg 
    1325                 1330                 1335             


Gln His  His Asp Glu Tyr Glu  Asp Glu Ile Arg Met  Met Ser Thr 
    1340                 1345                 1350             


Gly Ser  Lys Lys Ser Leu Leu  Ser His Glu Phe Gln  Asp Glu Thr 
    1355                 1360                 1365             


Asp Thr  Glu Glu Glu Thr Leu  Tyr Ser Ser Lys His  
    1370                 1375                 1380 


<210>  145
<211>  681
<212>  PRT
<213>  homo sapiens

<400>  145

Met Ser Lys Thr Phe Leu Arg Pro Lys Val Ser Ser Thr Lys Val Thr 
1               5                   10                  15      


Asp Trp Val Asp Pro Ser Phe Asp Asp Phe Leu Glu Cys Ser Gly Val 
            20                  25                  30          


Ser Thr Ile Thr Ala Thr Ser Leu Gly Val Asn Asn Ser Ser His Arg 
        35                  40                  45              


Arg Lys Asn Gly Pro Ser Thr Leu Glu Ser Ser Arg Phe Pro Ala Arg 
    50                  55                  60                  


Lys Arg Gly Asn Leu Ser Ser Leu Glu Gln Ile Tyr Gly Leu Glu Asn 
65                  70                  75                  80  


Ser Lys Glu Tyr Leu Ser Glu Asn Glu Pro Trp Val Asp Lys Tyr Lys 
                85                  90                  95      


Pro Glu Thr Gln His Glu Leu Ala Val His Lys Lys Lys Ile Glu Glu 
            100                 105                 110         


Val Glu Thr Trp Leu Lys Ala Gln Val Leu Glu Arg Gln Pro Lys Gln 
        115                 120                 125             


Gly Gly Ser Ile Leu Leu Ile Thr Gly Pro Pro Gly Cys Gly Lys Thr 
    130                 135                 140                 


Thr Thr Leu Lys Ile Leu Ser Lys Glu His Gly Ile Gln Val Gln Glu 
145                 150                 155                 160 


Trp Ile Asn Pro Val Leu Pro Asp Phe Gln Lys Asp Asp Phe Lys Gly 
                165                 170                 175     


Met Phe Asn Thr Glu Ser Ser Phe His Met Phe Pro Tyr Gln Ser Gln 
            180                 185                 190         


Ile Ala Val Phe Lys Glu Phe Leu Leu Arg Ala Thr Lys Tyr Asn Lys 
        195                 200                 205             


Leu Gln Met Leu Gly Asp Asp Leu Arg Thr Asp Lys Lys Ile Ile Leu 
    210                 215                 220                 


Val Glu Asp Leu Pro Asn Gln Phe Tyr Arg Asp Ser His Thr Leu His 
225                 230                 235                 240 


Glu Val Leu Arg Lys Tyr Val Arg Ile Gly Arg Cys Pro Leu Ile Phe 
                245                 250                 255     


Ile Ile Ser Asp Ser Leu Ser Gly Asp Asn Asn Gln Arg Leu Leu Phe 
            260                 265                 270         


Pro Lys Glu Ile Gln Glu Glu Cys Ser Ile Ser Asn Ile Ser Phe Asn 
        275                 280                 285             


Pro Val Ala Pro Thr Ile Met Met Lys Phe Leu Asn Arg Ile Val Thr 
    290                 295                 300                 


Ile Glu Ala Asn Lys Asn Gly Gly Lys Ile Thr Val Pro Asp Lys Thr 
305                 310                 315                 320 


Ser Leu Glu Leu Leu Cys Gln Gly Cys Ser Gly Asp Ile Arg Ser Ala 
                325                 330                 335     


Ile Asn Ser Leu Gln Phe Ser Ser Ser Lys Gly Glu Asn Asn Leu Arg 
            340                 345                 350         


Pro Arg Lys Lys Gly Met Ser Leu Lys Ser Asp Ala Val Leu Ser Lys 
        355                 360                 365             


Ser Lys Arg Arg Lys Lys Pro Asp Arg Val Phe Glu Asn Gln Glu Val 
    370                 375                 380                 


Gln Ala Ile Gly Gly Lys Asp Val Ser Leu Phe Leu Phe Arg Ala Leu 
385                 390                 395                 400 


Gly Lys Ile Leu Tyr Cys Lys Arg Ala Ser Leu Thr Glu Leu Asp Ser 
                405                 410                 415     


Pro Arg Leu Pro Ser His Leu Ser Glu Tyr Glu Arg Asp Thr Leu Leu 
            420                 425                 430         


Val Glu Pro Glu Glu Val Val Glu Met Ser His Met Pro Gly Asp Leu 
        435                 440                 445             


Phe Asn Leu Tyr Leu His Gln Asn Tyr Ile Asp Phe Phe Met Glu Ile 
    450                 455                 460                 


Asp Asp Ile Val Arg Ala Ser Glu Phe Leu Ser Phe Ala Asp Ile Leu 
465                 470                 475                 480 


Ser Gly Asp Trp Asn Thr Arg Ser Leu Leu Arg Glu Tyr Ser Thr Ser 
                485                 490                 495     


Ile Ala Thr Arg Gly Val Met His Ser Asn Lys Ala Arg Gly Tyr Ala 
            500                 505                 510         


His Cys Gln Gly Gly Gly Ser Ser Phe Arg Pro Leu His Lys Pro Gln 
        515                 520                 525             


Trp Phe Leu Ile Asn Lys Lys Tyr Arg Glu Asn Cys Leu Ala Ala Lys 
    530                 535                 540                 


Ala Leu Phe Pro Asp Phe Cys Leu Pro Ala Leu Cys Leu Gln Thr Gln 
545                 550                 555                 560 


Leu Leu Pro Tyr Leu Ala Leu Leu Thr Ile Pro Met Arg Asn Gln Ala 
                565                 570                 575     


Gln Ile Ser Phe Ile Gln Asp Ile Gly Arg Leu Pro Leu Lys Arg His 
            580                 585                 590         


Phe Gly Arg Leu Lys Met Glu Ala Leu Thr Asp Arg Glu His Gly Met 
        595                 600                 605             


Ile Asp Pro Asp Ser Gly Asp Glu Ala Gln Leu Asn Gly Gly His Ser 
    610                 615                 620                 


Ala Glu Glu Ser Leu Gly Glu Pro Thr Gln Ala Thr Val Pro Glu Thr 
625                 630                 635                 640 


Trp Ser Leu Pro Leu Ser Gln Asn Ser Ala Ser Glu Leu Pro Ala Ser 
                645                 650                 655     


Gln Pro Gln Pro Phe Ser Ala Gln Gly Asp Met Glu Glu Asn Ile Ile 
            660                 665                 670         


Ile Glu Asp Tyr Glu Ser Asp Gly Thr 
        675                 680     


<210>  146
<211>  3210
<212>  PRT
<213>  homo sapiens

<400>  146

Met Ser Trp Ala Leu Glu Glu Trp Lys Glu Gly Leu Pro Thr Arg Ala 
1               5                   10                  15      


Leu Gln Lys Ile Gln Glu Leu Glu Gly Gln Leu Asp Lys Leu Lys Lys 
            20                  25                  30          


Glu Lys Gln Gln Arg Gln Phe Gln Leu Asp Ser Leu Glu Ala Ala Leu 
        35                  40                  45              


Gln Lys Gln Lys Gln Lys Val Glu Asn Glu Lys Thr Glu Gly Thr Asn 
    50                  55                  60                  


Leu Lys Arg Glu Asn Gln Arg Leu Met Glu Ile Cys Glu Ser Leu Glu 
65                  70                  75                  80  


Lys Thr Lys Gln Lys Ile Ser His Glu Leu Gln Val Lys Glu Ser Gln 
                85                  90                  95      


Val Asn Phe Gln Glu Gly Gln Leu Asn Ser Gly Lys Lys Gln Ile Glu 
            100                 105                 110         


Lys Leu Glu Gln Glu Leu Lys Arg Cys Lys Ser Glu Leu Glu Arg Ser 
        115                 120                 125             


Gln Gln Ala Ala Gln Ser Ala Asp Val Ser Leu Asn Pro Cys Asn Thr 
    130                 135                 140                 


Pro Gln Lys Ile Phe Thr Thr Pro Leu Thr Pro Ser Gln Tyr Tyr Ser 
145                 150                 155                 160 


Gly Ser Lys Tyr Glu Asp Leu Lys Glu Lys Tyr Asn Lys Glu Val Glu 
                165                 170                 175     


Glu Arg Lys Arg Leu Glu Ala Glu Val Lys Ala Leu Gln Ala Lys Lys 
            180                 185                 190         


Ala Ser Gln Thr Leu Pro Gln Ala Thr Met Asn His Arg Asp Ile Ala 
        195                 200                 205             


Arg His Gln Ala Ser Ser Ser Val Phe Ser Trp Gln Gln Glu Lys Thr 
    210                 215                 220                 


Pro Ser His Leu Ser Ser Asn Ser Gln Arg Thr Pro Ile Arg Arg Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Tyr Phe Ser Gly Glu Gln Glu Val Thr Pro Ser Arg 
                245                 250                 255     


Ser Thr Leu Gln Ile Gly Lys Arg Asp Ala Asn Ser Ser Phe Phe Asp 
            260                 265                 270         


Asn Ser Ser Ser Pro His Leu Leu Asp Gln Leu Lys Ala Gln Asn Gln 
        275                 280                 285             


Glu Leu Arg Asn Lys Ile Asn Glu Leu Glu Leu Arg Leu Gln Gly His 
    290                 295                 300                 


Glu Lys Glu Met Lys Gly Gln Val Asn Lys Phe Gln Glu Leu Gln Leu 
305                 310                 315                 320 


Gln Leu Glu Lys Ala Lys Val Glu Leu Ile Glu Lys Glu Lys Val Leu 
                325                 330                 335     


Asn Lys Cys Arg Asp Glu Leu Val Arg Thr Thr Ala Gln Tyr Asp Gln 
            340                 345                 350         


Ala Ser Thr Lys Tyr Thr Ala Leu Glu Gln Lys Leu Lys Lys Leu Thr 
        355                 360                 365             


Glu Asp Leu Ser Cys Gln Arg Gln Asn Ala Glu Ser Ala Arg Cys Ser 
    370                 375                 380                 


Leu Glu Gln Lys Ile Lys Glu Lys Glu Lys Glu Phe Gln Glu Glu Leu 
385                 390                 395                 400 


Ser Arg Gln Gln Arg Ser Phe Gln Thr Leu Asp Gln Glu Cys Ile Gln 
                405                 410                 415     


Met Lys Ala Arg Leu Thr Gln Glu Leu Gln Gln Ala Lys Asn Met His 
            420                 425                 430         


Asn Val Leu Gln Ala Glu Leu Asp Lys Leu Thr Ser Val Lys Gln Gln 
        435                 440                 445             


Leu Glu Asn Asn Leu Glu Glu Phe Lys Gln Lys Leu Cys Arg Ala Glu 
    450                 455                 460                 


Gln Ala Phe Gln Ala Ser Gln Ile Lys Glu Asn Glu Leu Arg Arg Ser 
465                 470                 475                 480 


Met Glu Glu Met Lys Lys Glu Asn Asn Leu Leu Lys Ser His Ser Glu 
                485                 490                 495     


Gln Lys Ala Arg Glu Val Cys His Leu Glu Ala Glu Leu Lys Asn Ile 
            500                 505                 510         


Lys Gln Cys Leu Asn Gln Ser Gln Asn Phe Ala Glu Glu Met Lys Ala 
        515                 520                 525             


Lys Asn Thr Ser Gln Glu Thr Met Leu Arg Asp Leu Gln Glu Lys Ile 
    530                 535                 540                 


Asn Gln Gln Glu Asn Ser Leu Thr Leu Glu Lys Leu Lys Leu Ala Val 
545                 550                 555                 560 


Ala Asp Leu Glu Lys Gln Arg Asp Cys Ser Gln Asp Leu Leu Lys Lys 
                565                 570                 575     


Arg Glu His His Ile Glu Gln Leu Asn Asp Lys Leu Ser Lys Thr Glu 
            580                 585                 590         


Lys Glu Ser Lys Ala Leu Leu Ser Ala Leu Glu Leu Lys Lys Lys Glu 
        595                 600                 605             


Tyr Glu Glu Leu Lys Glu Glu Lys Thr Leu Phe Ser Cys Trp Lys Ser 
    610                 615                 620                 


Glu Asn Glu Lys Leu Leu Thr Gln Met Glu Ser Glu Lys Glu Asn Leu 
625                 630                 635                 640 


Gln Ser Lys Ile Asn His Leu Glu Thr Cys Leu Lys Thr Gln Gln Ile 
                645                 650                 655     


Lys Ser His Glu Tyr Asn Glu Arg Val Arg Thr Leu Glu Met Asp Arg 
            660                 665                 670         


Glu Asn Leu Ser Val Glu Ile Arg Asn Leu His Asn Val Leu Asp Ser 
        675                 680                 685             


Lys Ser Val Glu Val Glu Thr Gln Lys Leu Ala Tyr Met Glu Leu Gln 
    690                 695                 700                 


Gln Lys Ala Glu Phe Ser Asp Gln Lys His Gln Lys Glu Ile Glu Asn 
705                 710                 715                 720 


Met Cys Leu Lys Thr Ser Gln Leu Thr Gly Gln Val Glu Asp Leu Glu 
                725                 730                 735     


His Lys Leu Gln Leu Leu Ser Asn Glu Ile Met Asp Lys Asp Arg Cys 
            740                 745                 750         


Tyr Gln Asp Leu His Ala Glu Tyr Glu Ser Leu Arg Asp Leu Leu Lys 
        755                 760                 765             


Ser Lys Asp Ala Ser Leu Val Thr Asn Glu Asp His Gln Arg Ser Leu 
    770                 775                 780                 


Leu Ala Phe Asp Gln Gln Pro Ala Met His His Ser Phe Ala Asn Ile 
785                 790                 795                 800 


Ile Gly Glu Gln Gly Ser Met Pro Ser Glu Arg Ser Glu Cys Arg Leu 
                805                 810                 815     


Glu Ala Asp Gln Ser Pro Lys Asn Ser Ala Ile Leu Gln Asn Arg Val 
            820                 825                 830         


Asp Ser Leu Glu Phe Ser Leu Glu Ser Gln Lys Gln Met Asn Ser Asp 
        835                 840                 845             


Leu Gln Lys Gln Cys Glu Glu Leu Val Gln Ile Lys Gly Glu Ile Glu 
    850                 855                 860                 


Glu Asn Leu Met Lys Ala Glu Gln Met His Gln Ser Phe Val Ala Glu 
865                 870                 875                 880 


Thr Ser Gln Arg Ile Ser Lys Leu Gln Glu Asp Thr Ser Ala His Gln 
                885                 890                 895     


Asn Val Val Ala Glu Thr Leu Ser Ala Leu Glu Asn Lys Glu Lys Glu 
            900                 905                 910         


Leu Gln Leu Leu Asn Asp Lys Val Glu Thr Glu Gln Ala Glu Ile Gln 
        915                 920                 925             


Glu Leu Lys Lys Ser Asn His Leu Leu Glu Asp Ser Leu Lys Glu Leu 
    930                 935                 940                 


Gln Leu Leu Ser Glu Thr Leu Ser Leu Glu Lys Lys Glu Met Ser Ser 
945                 950                 955                 960 


Ile Ile Ser Leu Asn Lys Arg Glu Ile Glu Glu Leu Thr Gln Glu Asn 
                965                 970                 975     


Gly Thr Leu Lys Glu Ile Asn Ala Ser Leu Asn Gln Glu Lys Met Asn 
            980                 985                 990         


Leu Ile Gln Lys Ser Glu Ser Phe  Ala Asn Tyr Ile Asp  Glu Arg Glu 
        995                 1000                 1005             


Lys Ser  Ile Ser Glu Leu Ser  Asp Gln Tyr Lys Gln  Glu Lys Leu 
    1010                 1015                 1020             


Ile Leu  Leu Gln Arg Cys Glu  Glu Thr Gly Asn Ala  Tyr Glu Asp 
    1025                 1030                 1035             


Leu Ser  Gln Lys Tyr Lys Ala  Ala Gln Glu Lys Asn  Ser Lys Leu 
    1040                 1045                 1050             


Glu Cys  Leu Leu Asn Glu Cys  Thr Ser Leu Cys Glu  Asn Arg Lys 
    1055                 1060                 1065             


Asn Glu  Leu Glu Gln Leu Lys  Glu Ala Phe Ala Lys  Glu His Gln 
    1070                 1075                 1080             


Glu Phe  Leu Thr Lys Leu Ala  Phe Ala Glu Glu Arg  Asn Gln Asn 
    1085                 1090                 1095             


Leu Met  Leu Glu Leu Glu Thr  Val Gln Gln Ala Leu  Arg Ser Glu 
    1100                 1105                 1110             


Met Thr  Asp Asn Gln Asn Asn  Ser Lys Ser Glu Ala  Gly Gly Leu 
    1115                 1120                 1125             


Lys Gln  Glu Ile Met Thr Leu  Lys Glu Glu Gln Asn  Lys Met Gln 
    1130                 1135                 1140             


Lys Glu  Val Asn Asp Leu Leu  Gln Glu Asn Glu Gln  Leu Met Lys 
    1145                 1150                 1155             


Val Met  Lys Thr Lys His Glu  Cys Gln Asn Leu Glu  Ser Glu Pro 
    1160                 1165                 1170             


Ile Arg  Asn Ser Val Lys Glu  Arg Glu Ser Glu Arg  Asn Gln Cys 
    1175                 1180                 1185             


Asn Phe  Lys Pro Gln Met Asp  Leu Glu Val Lys Glu  Ile Ser Leu 
    1190                 1195                 1200             


Asp Ser  Tyr Asn Ala Gln Leu  Val Gln Leu Glu Ala  Met Leu Arg 
    1205                 1210                 1215             


Asn Lys  Glu Leu Lys Leu Gln  Glu Ser Glu Lys Glu  Lys Glu Cys 
    1220                 1225                 1230             


Leu Gln  His Glu Leu Gln Thr  Ile Arg Gly Asp Leu  Glu Thr Ser 
    1235                 1240                 1245             


Asn Leu  Gln Asp Met Gln Ser  Gln Glu Ile Ser Gly  Leu Lys Asp 
    1250                 1255                 1260             


Cys Glu  Ile Asp Ala Glu Glu  Lys Tyr Ile Ser Gly  Pro His Glu 
    1265                 1270                 1275             


Leu Ser  Thr Ser Gln Asn Asp  Asn Ala His Leu Gln  Cys Ser Leu 
    1280                 1285                 1290             


Gln Thr  Thr Met Asn Lys Leu  Asn Glu Leu Glu Lys  Ile Cys Glu 
    1295                 1300                 1305             


Ile Leu  Gln Ala Glu Lys Tyr  Glu Leu Val Thr Glu  Leu Asn Asp 
    1310                 1315                 1320             


Ser Arg  Ser Glu Cys Ile Thr  Ala Thr Arg Lys Met  Ala Glu Glu 
    1325                 1330                 1335             


Val Gly  Lys Leu Leu Asn Glu  Val Lys Ile Leu Asn  Asp Asp Ser 
    1340                 1345                 1350             


Gly Leu  Leu His Gly Glu Leu  Val Glu Asp Ile Pro  Gly Gly Glu 
    1355                 1360                 1365             


Phe Gly  Glu Gln Pro Asn Glu  Gln His Pro Val Ser  Leu Ala Pro 
    1370                 1375                 1380             


Leu Asp  Glu Ser Asn Ser Tyr  Glu His Leu Thr Leu  Ser Asp Lys 
    1385                 1390                 1395             


Glu Val  Gln Met His Phe Ala  Glu Leu Gln Glu Lys  Phe Leu Ser 
    1400                 1405                 1410             


Leu Gln  Ser Glu His Lys Ile  Leu His Asp Gln His  Cys Gln Met 
    1415                 1420                 1425             


Ser Ser  Lys Met Ser Glu Leu  Gln Thr Tyr Val Asp  Ser Leu Lys 
    1430                 1435                 1440             


Ala Glu  Asn Leu Val Leu Ser  Thr Asn Leu Arg Asn  Phe Gln Gly 
    1445                 1450                 1455             


Asp Leu  Val Lys Glu Met Gln  Leu Gly Leu Glu Glu  Gly Leu Val 
    1460                 1465                 1470             


Pro Ser  Leu Ser Ser Ser Cys  Val Pro Asp Ser Ser  Ser Leu Ser 
    1475                 1480                 1485             


Ser Leu  Gly Asp Ser Ser Phe  Tyr Arg Ala Leu Leu  Glu Gln Thr 
    1490                 1495                 1500             


Gly Asp  Met Ser Leu Leu Ser  Asn Leu Glu Gly Ala  Val Ser Ala 
    1505                 1510                 1515             


Asn Gln  Cys Ser Val Asp Glu  Val Phe Cys Ser Ser  Leu Gln Thr 
    1520                 1525                 1530             


Tyr Val  Asp Ser Leu Lys Ala  Glu Asn Leu Val Leu  Ser Thr Asn 
    1535                 1540                 1545             


Leu Arg  Asn Phe Gln Gly Asp  Leu Val Lys Glu Met  Gln Leu Gly 
    1550                 1555                 1560             


Leu Glu  Glu Gly Leu Val Pro  Ser Leu Ser Ser Ser  Cys Val Pro 
    1565                 1570                 1575             


Asp Ser  Ser Ser Leu Ser Ser  Leu Gly Asp Ser Ser  Phe Tyr Arg 
    1580                 1585                 1590             


Ala Leu  Leu Glu Gln Thr Gly  Asp Met Ser Leu Leu  Ser Asn Leu 
    1595                 1600                 1605             


Glu Gly  Val Val Ser Ala Asn  Gln Cys Ser Val Asp  Glu Val Phe 
    1610                 1615                 1620             


Cys Ser  Ser Leu Gln Glu Glu  Asn Leu Thr Arg Lys  Glu Thr Pro 
    1625                 1630                 1635             


Ser Ala  Pro Ala Lys Gly Val  Glu Glu Leu Glu Ser  Leu Cys Glu 
    1640                 1645                 1650             


Val Tyr  Arg Gln Ser Leu Glu  Lys Leu Glu Glu Lys  Met Glu Ser 
    1655                 1660                 1665             


Gln Gly  Ile Met Lys Asn Lys  Glu Ile Gln Glu Leu  Glu Gln Leu 
    1670                 1675                 1680             


Leu Ser  Ser Glu Arg Gln Glu  Leu Asp Cys Leu Arg  Lys Gln Tyr 
    1685                 1690                 1695             


Leu Ser  Glu Asn Glu Gln Trp  Gln Gln Lys Leu Thr  Ser Val Thr 
    1700                 1705                 1710             


Leu Glu  Met Glu Ser Lys Leu  Ala Ala Glu Lys Lys  Gln Thr Glu 
    1715                 1720                 1725             


Gln Leu  Ser Leu Glu Leu Glu  Val Ala Arg Leu Gln  Leu Gln Gly 
    1730                 1735                 1740             


Leu Asp  Leu Ser Ser Arg Ser  Leu Leu Gly Ile Asp  Thr Glu Asp 
    1745                 1750                 1755             


Ala Ile  Gln Gly Arg Asn Glu  Ser Cys Asp Ile Ser  Lys Glu His 
    1760                 1765                 1770             


Thr Ser  Glu Thr Thr Glu Arg  Thr Pro Lys His Asp  Val His Gln 
    1775                 1780                 1785             


Ile Cys  Asp Lys Asp Ala Gln  Gln Asp Leu Asn Leu  Asp Ile Glu 
    1790                 1795                 1800             


Lys Ile  Thr Glu Thr Gly Ala  Val Lys Pro Thr Gly  Glu Cys Ser 
    1805                 1810                 1815             


Gly Glu  Gln Ser Pro Asp Thr  Asn Tyr Glu Pro Pro  Gly Glu Asp 
    1820                 1825                 1830             


Lys Thr  Gln Gly Ser Ser Glu  Cys Ile Ser Glu Leu  Ser Phe Ser 
    1835                 1840                 1845             


Gly Pro  Asn Ala Leu Val Pro  Met Asp Phe Leu Gly  Asn Gln Glu 
    1850                 1855                 1860             


Asp Ile  His Asn Leu Gln Leu  Arg Val Lys Glu Thr  Ser Asn Glu 
    1865                 1870                 1875             


Asn Leu  Arg Leu Leu His Val  Ile Glu Asp Arg Asp  Arg Lys Val 
    1880                 1885                 1890             


Glu Ser  Leu Leu Asn Glu Met  Lys Glu Leu Asp Ser  Lys Leu His 
    1895                 1900                 1905             


Leu Gln  Glu Val Gln Leu Met  Thr Lys Ile Glu Ala  Cys Ile Glu 
    1910                 1915                 1920             


Leu Glu  Lys Ile Val Gly Glu  Leu Lys Lys Glu Asn  Ser Asp Leu 
    1925                 1930                 1935             


Ser Glu  Lys Leu Glu Tyr Phe  Ser Cys Asp His Gln  Glu Leu Leu 
    1940                 1945                 1950             


Gln Arg  Val Glu Thr Ser Glu  Gly Leu Asn Ser Asp  Leu Glu Met 
    1955                 1960                 1965             


His Ala  Asp Lys Ser Ser Arg  Glu Asp Ile Gly Asp  Asn Val Ala 
    1970                 1975                 1980             


Lys Val  Asn Asp Ser Trp Lys  Glu Arg Phe Leu Asp  Val Glu Asn 
    1985                 1990                 1995             


Glu Leu  Ser Arg Ile Arg Ser  Glu Lys Ala Ser Ile  Glu His Glu 
    2000                 2005                 2010             


Ala Leu  Tyr Leu Glu Ala Asp  Leu Glu Val Val Gln  Thr Glu Lys 
    2015                 2020                 2025             


Leu Cys  Leu Glu Lys Asp Asn  Glu Asn Lys Gln Lys  Val Ile Val 
    2030                 2035                 2040             


Cys Leu  Glu Glu Glu Leu Ser  Val Val Thr Ser Glu  Arg Asn Gln 
    2045                 2050                 2055             


Leu Arg  Gly Glu Leu Asp Thr  Met Ser Lys Lys Thr  Thr Ala Leu 
    2060                 2065                 2070             


Asp Gln  Leu Ser Glu Lys Met  Lys Glu Lys Thr Gln  Glu Leu Glu 
    2075                 2080                 2085             


Ser His  Gln Ser Glu Cys Leu  His Cys Ile Gln Val  Ala Glu Ala 
    2090                 2095                 2100             


Glu Val  Lys Glu Lys Thr Glu  Leu Leu Gln Thr Leu  Ser Ser Asp 
    2105                 2110                 2115             


Val Ser  Glu Leu Leu Lys Asp  Lys Thr His Leu Gln  Glu Lys Leu 
    2120                 2125                 2130             


Gln Ser  Leu Glu Lys Asp Ser  Gln Ala Leu Ser Leu  Thr Lys Cys 
    2135                 2140                 2145             


Glu Leu  Glu Asn Gln Ile Ala  Gln Leu Asn Lys Glu  Lys Glu Leu 
    2150                 2155                 2160             


Leu Val  Lys Glu Ser Glu Ser  Leu Gln Ala Arg Leu  Ser Glu Ser 
    2165                 2170                 2175             


Asp Tyr  Glu Lys Leu Asn Val  Ser Lys Ala Leu Glu  Ala Ala Leu 
    2180                 2185                 2190             


Val Glu  Lys Gly Glu Phe Ala  Leu Arg Leu Ser Ser  Thr Gln Glu 
    2195                 2200                 2205             


Glu Val  His Gln Leu Arg Arg  Gly Ile Glu Lys Leu  Arg Val Arg 
    2210                 2215                 2220             


Ile Glu  Ala Asp Glu Lys Lys  Gln Leu His Ile Ala  Glu Lys Leu 
    2225                 2230                 2235             


Lys Glu  Arg Glu Arg Glu Asn  Asp Ser Leu Lys Asp  Lys Val Glu 
    2240                 2245                 2250             


Asn Leu  Glu Arg Glu Leu Gln  Met Ser Glu Glu Asn  Gln Glu Leu 
    2255                 2260                 2265             


Val Ile  Leu Asp Ala Glu Asn  Ser Lys Ala Glu Val  Glu Thr Leu 
    2270                 2275                 2280             


Lys Thr  Gln Ile Glu Glu Met  Ala Arg Ser Leu Lys  Val Phe Glu 
    2285                 2290                 2295             


Leu Asp  Leu Val Thr Leu Arg  Ser Glu Lys Glu Asn  Leu Thr Lys 
    2300                 2305                 2310             


Gln Ile  Gln Glu Lys Gln Gly  Gln Leu Ser Glu Leu  Asp Lys Leu 
    2315                 2320                 2325             


Leu Ser  Ser Phe Lys Ser Leu  Leu Glu Glu Lys Glu  Gln Ala Glu 
    2330                 2335                 2340             


Ile Gln  Ile Lys Glu Glu Ser  Lys Thr Ala Val Glu  Met Leu Gln 
    2345                 2350                 2355             


Asn Gln  Leu Lys Glu Leu Asn  Glu Ala Val Ala Ala  Leu Cys Gly 
    2360                 2365                 2370             


Asp Gln  Glu Ile Met Lys Ala  Thr Glu Gln Ser Leu  Asp Pro Pro 
    2375                 2380                 2385             


Ile Glu  Glu Glu His Gln Leu  Arg Asn Ser Ile Glu  Lys Leu Arg 
    2390                 2395                 2400             


Ala Arg  Leu Glu Ala Asp Glu  Lys Lys Gln Leu Cys  Val Leu Gln 
    2405                 2410                 2415             


Gln Leu  Lys Glu Ser Glu His  His Ala Asp Leu Leu  Lys Gly Arg 
    2420                 2425                 2430             


Val Glu  Asn Leu Glu Arg Glu  Leu Glu Ile Ala Arg  Thr Asn Gln 
    2435                 2440                 2445             


Glu His  Ala Ala Leu Glu Ala  Glu Asn Ser Lys Gly  Glu Val Glu 
    2450                 2455                 2460             


Thr Leu  Lys Ala Lys Ile Glu  Gly Met Thr Gln Ser  Leu Arg Gly 
    2465                 2470                 2475             


Leu Glu  Leu Asp Val Val Thr  Ile Arg Ser Glu Lys  Glu Asn Leu 
    2480                 2485                 2490             


Thr Asn  Glu Leu Gln Lys Glu  Gln Glu Arg Ile Ser  Glu Leu Glu 
    2495                 2500                 2505             


Ile Ile  Asn Ser Ser Phe Glu  Asn Ile Leu Gln Glu  Lys Glu Gln 
    2510                 2515                 2520             


Glu Lys  Val Gln Met Lys Glu  Lys Ser Ser Thr Ala  Met Glu Met 
    2525                 2530                 2535             


Leu Gln  Thr Gln Leu Lys Glu  Leu Asn Glu Arg Val  Ala Ala Leu 
    2540                 2545                 2550             


His Asn  Asp Gln Glu Ala Cys  Lys Ala Lys Glu Gln  Asn Leu Ser 
    2555                 2560                 2565             


Ser Gln  Val Glu Cys Leu Glu  Leu Glu Lys Ala Gln  Leu Leu Gln 
    2570                 2575                 2580             


Gly Leu  Asp Glu Ala Lys Asn  Asn Tyr Ile Val Leu  Gln Ser Ser 
    2585                 2590                 2595             


Val Asn  Gly Leu Ile Gln Glu  Val Glu Asp Gly Lys  Gln Lys Leu 
    2600                 2605                 2610             


Glu Lys  Lys Asp Glu Glu Ile  Ser Arg Leu Lys Asn  Gln Ile Gln 
    2615                 2620                 2625             


Asp Gln  Glu Gln Leu Val Ser  Lys Leu Ser Gln Val  Glu Gly Glu 
    2630                 2635                 2640             


His Gln  Leu Trp Lys Glu Gln  Asn Leu Glu Leu Arg  Asn Leu Thr 
    2645                 2650                 2655             


Val Glu  Leu Glu Gln Lys Ile  Gln Val Leu Gln Ser  Lys Asn Ala 
    2660                 2665                 2670             


Ser Leu  Gln Asp Thr Leu Glu  Val Leu Gln Ser Ser  Tyr Lys Asn 
    2675                 2680                 2685             


Leu Glu  Asn Glu Leu Glu Leu  Thr Lys Met Asp Lys  Met Ser Phe 
    2690                 2695                 2700             


Val Glu  Lys Val Asn Lys Met  Thr Ala Lys Glu Thr  Glu Leu Gln 
    2705                 2710                 2715             


Arg Glu  Met His Glu Met Ala  Gln Lys Thr Ala Glu  Leu Gln Glu 
    2720                 2725                 2730             


Glu Leu  Ser Gly Glu Lys Asn  Arg Leu Ala Gly Glu  Leu Gln Leu 
    2735                 2740                 2745             


Leu Leu  Glu Glu Ile Lys Ser  Ser Lys Asp Gln Leu  Lys Glu Leu 
    2750                 2755                 2760             


Thr Leu  Glu Asn Ser Glu Leu  Lys Lys Ser Leu Asp  Cys Met His 
    2765                 2770                 2775             


Lys Asp  Gln Val Glu Lys Glu  Gly Lys Val Arg Glu  Glu Ile Ala 
    2780                 2785                 2790             


Glu Tyr  Gln Leu Arg Leu His  Glu Ala Glu Lys Lys  His Gln Ala 
    2795                 2800                 2805             


Leu Leu  Leu Asp Thr Asn Lys  Gln Tyr Glu Val Glu  Ile Gln Thr 
    2810                 2815                 2820             


Tyr Arg  Glu Lys Leu Thr Ser  Lys Glu Glu Cys Leu  Ser Ser Gln 
    2825                 2830                 2835             


Lys Leu  Glu Ile Asp Leu Leu  Lys Ser Ser Lys Glu  Glu Leu Asn 
    2840                 2845                 2850             


Asn Ser  Leu Lys Ala Thr Thr  Gln Ile Leu Glu Glu  Leu Lys Lys 
    2855                 2860                 2865             


Thr Lys  Met Asp Asn Leu Lys  Tyr Val Asn Gln Leu  Lys Lys Glu 
    2870                 2875                 2880             


Asn Glu  Arg Ala Gln Gly Lys  Met Lys Leu Leu Ile  Lys Ser Cys 
    2885                 2890                 2895             


Lys Gln  Leu Glu Glu Glu Lys  Glu Ile Leu Gln Lys  Glu Leu Ser 
    2900                 2905                 2910             


Gln Leu  Gln Ala Ala Gln Glu  Lys Gln Lys Thr Gly  Thr Val Met 
    2915                 2920                 2925             


Asp Thr  Lys Val Asp Glu Leu  Thr Thr Glu Ile Lys  Glu Leu Lys 
    2930                 2935                 2940             


Glu Thr  Leu Glu Glu Lys Thr  Lys Glu Ala Asp Glu  Tyr Leu Asp 
    2945                 2950                 2955             


Lys Tyr  Cys Ser Leu Leu Ile  Ser His Glu Lys Leu  Glu Lys Ala 
    2960                 2965                 2970             


Lys Glu  Met Leu Glu Thr Gln  Val Ala His Leu Cys  Ser Gln Gln 
    2975                 2980                 2985             


Ser Lys  Gln Asp Ser Arg Gly  Ser Pro Leu Leu Gly  Pro Val Val 
    2990                 2995                 3000             


Pro Gly  Pro Ser Pro Ile Pro  Ser Val Thr Glu Lys  Arg Leu Ser 
    3005                 3010                 3015             


Ser Gly  Gln Asn Lys Ala Ser  Gly Lys Arg Gln Arg  Ser Ser Gly 
    3020                 3025                 3030             


Ile Trp  Glu Asn Gly Arg Gly  Pro Thr Pro Ala Thr  Pro Glu Ser 
    3035                 3040                 3045             


Phe Ser  Lys Lys Ser Lys Lys  Ala Val Met Ser Gly  Ile His Pro 
    3050                 3055                 3060             


Ala Glu  Asp Thr Glu Gly Thr  Glu Phe Glu Pro Glu  Gly Leu Pro 
    3065                 3070                 3075             


Glu Val  Val Lys Lys Gly Phe  Ala Asp Ile Pro Thr  Gly Lys Thr 
    3080                 3085                 3090             


Ser Pro  Tyr Ile Leu Arg Arg  Thr Thr Met Ala Thr  Arg Thr Ser 
    3095                 3100                 3105             


Pro Arg  Leu Ala Ala Gln Lys  Leu Ala Leu Ser Pro  Leu Ser Leu 
    3110                 3115                 3120             


Gly Lys  Glu Asn Leu Ala Glu  Ser Ser Lys Pro Thr  Ala Gly Gly 
    3125                 3130                 3135             


Ser Arg  Ser Gln Lys Val Lys  Val Ala Gln Arg Ser  Pro Val Asp 
    3140                 3145                 3150             


Ser Gly  Thr Ile Leu Arg Glu  Pro Thr Thr Lys Ser  Val Pro Val 
    3155                 3160                 3165             


Asn Asn  Leu Pro Glu Arg Ser  Pro Thr Asp Ser Pro  Arg Glu Gly 
    3170                 3175                 3180             


Leu Arg  Val Lys Arg Gly Arg  Leu Val Pro Ser Pro  Lys Ala Gly 
    3185                 3190                 3195             


Leu Glu  Ser Asn Gly Ser Glu  Asn Cys Lys Val Gln  
    3200                 3205                 3210 


<210>  147
<211>  2032
<212>  PRT
<213>  homo sapiens

<400>  147

Met Gly Asp Asp Ser Glu Trp Leu Lys Leu Pro Val Asp Gln Lys Cys 
1               5                   10                  15      


Glu His Lys Leu Trp Lys Ala Arg Leu Ser Gly Tyr Glu Glu Ala Leu 
            20                  25                  30          


Lys Ile Phe Gln Lys Ile Lys Asp Glu Lys Ser Pro Glu Trp Ser Lys 
        35                  40                  45              


Phe Leu Gly Leu Ile Lys Lys Phe Val Thr Asp Ser Asn Ala Val Val 
    50                  55                  60                  


Gln Leu Lys Gly Leu Glu Ala Ala Leu Val Tyr Val Glu Asn Ala His 
65                  70                  75                  80  


Val Ala Gly Lys Thr Thr Gly Glu Val Val Ser Gly Val Val Ser Lys 
                85                  90                  95      


Val Phe Asn Gln Pro Lys Ala Lys Ala Lys Glu Leu Gly Ile Glu Ile 
            100                 105                 110         


Cys Leu Met Tyr Ile Glu Ile Glu Lys Gly Glu Ala Val Gln Glu Glu 
        115                 120                 125             


Leu Leu Lys Gly Leu Asp Asn Lys Asn Pro Lys Ile Ile Val Ala Cys 
    130                 135                 140                 


Ile Glu Thr Leu Arg Lys Ala Leu Ser Glu Phe Gly Ser Lys Ile Ile 
145                 150                 155                 160 


Leu Leu Lys Pro Ile Ile Lys Val Leu Pro Lys Leu Phe Glu Ser Arg 
                165                 170                 175     


Glu Lys Ala Val Arg Asp Glu Ala Lys Leu Ile Ala Val Glu Ile Tyr 
            180                 185                 190         


Arg Trp Ile Arg Asp Ala Leu Arg Pro Pro Leu Gln Asn Ile Asn Ser 
        195                 200                 205             


Val Gln Leu Lys Glu Leu Glu Glu Glu Trp Val Lys Leu Pro Thr Ser 
    210                 215                 220                 


Ala Pro Arg Pro Thr Arg Phe Leu Arg Ser Gln Gln Glu Leu Glu Ala 
225                 230                 235                 240 


Lys Leu Glu Gln Gln Gln Ser Ala Gly Gly Asp Ala Glu Gly Gly Gly 
                245                 250                 255     


Asp Asp Gly Asp Glu Val Pro Gln Ile Asp Ala Tyr Glu Leu Leu Glu 
            260                 265                 270         


Ala Val Glu Ile Leu Ser Lys Leu Pro Lys Asp Phe Tyr Asp Lys Ile 
        275                 280                 285             


Glu Ala Lys Lys Trp Gln Glu Arg Lys Glu Ala Leu Glu Ser Val Glu 
    290                 295                 300                 


Val Leu Ile Lys Asn Pro Lys Leu Glu Ala Gly Asp Tyr Ala Asp Leu 
305                 310                 315                 320 


Val Lys Ala Leu Lys Lys Val Val Gly Lys Asp Thr Asn Val Met Leu 
                325                 330                 335     


Val Ala Leu Ala Ala Lys Cys Leu Thr Gly Leu Ala Val Gly Leu Arg 
            340                 345                 350         


Lys Lys Phe Gly Gln Tyr Ala Gly His Val Val Pro Thr Ile Leu Glu 
        355                 360                 365             


Lys Phe Lys Glu Lys Lys Pro Gln Val Val Gln Ala Leu Gln Glu Ala 
    370                 375                 380                 


Ile Asp Ala Ile Phe Leu Thr Thr Thr Leu Gln Asn Ile Ser Glu Asp 
385                 390                 395                 400 


Val Leu Ala Val Met Asp Asn Lys Asn Pro Thr Ile Lys Gln Gln Thr 
                405                 410                 415     


Ser Leu Phe Ile Ala Arg Ser Phe Arg His Cys Thr Ala Ser Thr Leu 
            420                 425                 430         


Pro Lys Ser Leu Leu Lys Pro Phe Cys Ala Ala Leu Leu Lys His Ile 
        435                 440                 445             


Asn Asp Ser Ala Pro Glu Val Arg Asp Ala Ala Phe Glu Ala Leu Gly 
    450                 455                 460                 


Thr Ala Leu Lys Val Val Gly Glu Lys Ala Val Lys Pro Phe Leu Ala 
465                 470                 475                 480 


Asp Val Asp Lys Leu Lys Leu Asp Lys Ile Lys Glu Cys Ser Glu Lys 
                485                 490                 495     


Val Glu Leu Ile His Gly Lys Lys Ala Gly Leu Ala Ala Asp Lys Lys 
            500                 505                 510         


Glu Phe Lys Pro Leu Pro Gly Arg Thr Ala Ala Ser Gly Ala Ala Gly 
        515                 520                 525             


Asp Lys Asp Thr Lys Asp Ile Ser Ala Pro Lys Pro Gly Pro Leu Lys 
    530                 535                 540                 


Lys Ala Pro Ala Ala Lys Ala Gly Gly Pro Pro Lys Lys Gly Lys Pro 
545                 550                 555                 560 


Ala Ala Pro Gly Gly Ala Gly Asn Thr Gly Thr Lys Asn Lys Lys Gly 
                565                 570                 575     


Leu Glu Thr Lys Glu Ile Val Glu Pro Glu Leu Ser Ile Glu Val Cys 
            580                 585                 590         


Glu Glu Lys Ala Ser Ala Val Leu Pro Pro Thr Cys Ile Gln Leu Leu 
        595                 600                 605             


Asp Ser Ser Asn Trp Lys Glu Arg Leu Ala Cys Met Glu Glu Phe Gln 
    610                 615                 620                 


Lys Ala Val Glu Leu Met Asp Arg Thr Glu Met Pro Cys Gln Ala Leu 
625                 630                 635                 640 


Val Arg Met Leu Ala Lys Lys Pro Gly Trp Lys Glu Thr Asn Phe Gln 
                645                 650                 655     


Val Met Gln Met Lys Leu His Ile Val Ala Leu Ile Ala Gln Lys Gly 
            660                 665                 670         


Asn Phe Ser Lys Thr Ser Ala Gln Val Val Leu Asp Gly Leu Val Asp 
        675                 680                 685             


Lys Ile Gly Asp Val Lys Cys Gly Asn Asn Ala Lys Glu Ala Met Thr 
    690                 695                 700                 


Ala Ile Ala Glu Ala Cys Met Leu Pro Trp Thr Ala Glu Gln Val Val 
705                 710                 715                 720 


Ser Met Ala Phe Ser Gln Lys Asn Pro Lys Asn Gln Ser Glu Thr Leu 
                725                 730                 735     


Asn Trp Leu Ser Asn Ala Ile Lys Glu Phe Gly Phe Ser Gly Leu Asn 
            740                 745                 750         


Val Lys Ala Phe Ile Ser Asn Val Lys Thr Ala Leu Ala Ala Thr Asn 
        755                 760                 765             


Pro Ala Val Arg Thr Ala Ala Ile Thr Leu Leu Gly Val Met Tyr Leu 
    770                 775                 780                 


Tyr Val Gly Pro Ser Leu Arg Met Phe Phe Glu Asp Glu Lys Pro Ala 
785                 790                 795                 800 


Leu Leu Ser Gln Ile Asp Ala Glu Phe Glu Lys Met Gln Gly Gln Ser 
                805                 810                 815     


Pro Pro Ala Pro Thr Arg Gly Ile Ser Lys His Ser Thr Ser Gly Thr 
            820                 825                 830         


Asp Glu Gly Glu Asp Gly Asp Glu Pro Asp Asp Gly Ser Asn Asp Val 
        835                 840                 845             


Val Asp Leu Leu Pro Arg Thr Glu Ile Ser Asp Lys Ile Thr Ser Glu 
    850                 855                 860                 


Leu Val Ser Lys Ile Gly Asp Lys Asn Trp Lys Ile Arg Lys Glu Gly 
865                 870                 875                 880 


Leu Asp Glu Val Ala Gly Ile Ile Asn Asp Ala Lys Phe Ile Gln Pro 
                885                 890                 895     


Asn Ile Gly Glu Leu Pro Thr Ala Leu Lys Gly Arg Leu Asn Asp Ser 
            900                 905                 910         


Asn Lys Ile Leu Val Gln Gln Thr Leu Asn Ile Leu Gln Gln Leu Ala 
        915                 920                 925             


Val Ala Met Gly Pro Asn Ile Lys Gln His Val Lys Asn Leu Gly Ile 
    930                 935                 940                 


Pro Ile Ile Thr Val Leu Gly Asp Ser Lys Asn Asn Val Arg Ala Ala 
945                 950                 955                 960 


Ala Leu Ala Thr Val Asn Ala Trp Ala Glu Gln Thr Gly Met Lys Glu 
                965                 970                 975     


Trp Leu Glu Gly Glu Asp Leu Ser Glu Glu Leu Lys Lys Glu Asn Pro 
            980                 985                 990         


Phe Leu Arg Gln Glu Leu Leu Gly  Trp Leu Ala Glu Lys  Leu Pro Thr 
        995                 1000                 1005             


Leu Arg  Ser Thr Pro Thr Asp  Leu Ile Leu Cys Val  Pro His Leu 
    1010                 1015                 1020             


Tyr Ser  Cys Leu Glu Asp Arg  Asn Gly Asp Val Arg  Lys Lys Ala 
    1025                 1030                 1035             


Gln Asp  Ala Leu Pro Phe Phe  Met Met His Leu Gly  Tyr Glu Lys 
    1040                 1045                 1050             


Met Ala  Lys Ala Thr Gly Lys  Leu Lys Pro Thr Ser  Lys Asp Gln 
    1055                 1060                 1065             


Val Leu  Ala Met Leu Glu Lys  Ala Lys Val Asn Met  Pro Ala Lys 
    1070                 1075                 1080             


Pro Ala  Pro Pro Thr Lys Ala  Thr Ser Lys Pro Met  Gly Gly Ser 
    1085                 1090                 1095             


Ala Pro  Ala Lys Phe Gln Pro  Ala Ser Ala Pro Ala  Glu Asp Cys 
    1100                 1105                 1110             


Ile Ser  Ser Ser Thr Glu Pro  Lys Pro Asp Pro Lys  Lys Ala Lys 
    1115                 1120                 1125             


Ala Pro  Gly Leu Ser Ser Lys  Ala Lys Ser Ala Gln  Gly Lys Lys 
    1130                 1135                 1140             


Met Pro  Ser Lys Thr Ser Leu  Lys Glu Asp Glu Asp  Lys Ser Gly 
    1145                 1150                 1155             


Pro Ile  Phe Ile Val Val Pro  Asn Gly Lys Glu Gln  Arg Met Lys 
    1160                 1165                 1170             


Asp Glu  Lys Gly Leu Lys Val  Leu Lys Trp Asn Phe  Thr Thr Pro 
    1175                 1180                 1185             


Arg Asp  Glu Tyr Ile Glu Gln  Leu Lys Thr Gln Met  Ser Ser Cys 
    1190                 1195                 1200             


Val Ala  Lys Trp Leu Gln Asp  Glu Met Phe His Ser  Asp Phe Gln 
    1205                 1210                 1215             


His His  Asn Lys Ala Leu Ala  Val Met Val Asp His  Leu Glu Ser 
    1220                 1225                 1230             


Glu Lys  Glu Gly Val Ile Gly  Cys Leu Asp Leu Ile  Leu Lys Trp 
    1235                 1240                 1245             


Leu Thr  Leu Arg Phe Phe Asp  Thr Asn Thr Ser Val  Leu Met Lys 
    1250                 1255                 1260             


Ala Leu  Glu Tyr Leu Lys Leu  Leu Phe Thr Leu Leu  Ser Glu Glu 
    1265                 1270                 1275             


Glu Tyr  His Leu Thr Glu Asn  Glu Ala Ser Ser Phe  Ile Pro Tyr 
    1280                 1285                 1290             


Leu Val  Val Lys Val Gly Glu  Pro Lys Asp Val Ile  Arg Lys Asp 
    1295                 1300                 1305             


Val Arg  Ala Ile Leu Asn Arg  Met Cys Leu Val Tyr  Pro Ala Ser 
    1310                 1315                 1320             


Lys Met  Phe Pro Phe Ile Met  Glu Gly Thr Lys Ser  Lys Asn Ser 
    1325                 1330                 1335             


Lys Gln  Arg Ala Glu Cys Leu  Glu Glu Leu Gly Cys  Leu Val Glu 
    1340                 1345                 1350             


Ser Tyr  Gly Met Asn Val Cys  Gln Pro Thr Pro Gly  Lys Ala Leu 
    1355                 1360                 1365             


Lys Glu  Ile Ala Val His Ile  Gly Asp Arg Asp Asn  Ala Val Arg 
    1370                 1375                 1380             


Asn Ala  Ala Leu Asn Thr Ile  Val Thr Val Tyr Asn  Val His Gly 
    1385                 1390                 1395             


Asp Gln  Val Phe Lys Leu Ile  Gly Asn Leu Ser Glu  Lys Asp Met 
    1400                 1405                 1410             


Ser Met  Leu Glu Glu Arg Ile  Lys Arg Ser Ala Lys  Arg Pro Ser 
    1415                 1420                 1425             


Ala Ala  Pro Ile Lys Gln Val  Glu Glu Lys Pro Gln  Arg Ala Gln 
    1430                 1435                 1440             


Asn Ile  Ser Ser Asn Ala Asn  Met Leu Arg Lys Gly  Pro Ala Glu 
    1445                 1450                 1455             


Asp Met  Ser Ser Lys Leu Asn  Gln Ala Arg Ser Met  Ser Gly His 
    1460                 1465                 1470             


Pro Glu  Ala Ala Gln Met Val  Arg Arg Glu Phe Gln  Leu Asp Leu 
    1475                 1480                 1485             


Asp Glu  Ile Glu Asn Asp Asn  Gly Thr Val Arg Cys  Glu Met Pro 
    1490                 1495                 1500             


Glu Leu  Val Gln His Lys Leu  Asp Asp Ile Phe Glu  Pro Val Leu 
    1505                 1510                 1515             


Ile Pro  Glu Pro Lys Ile Arg  Ala Val Ser Pro His  Phe Asp Asp 
    1520                 1525                 1530             


Met His  Ser Asn Thr Ala Ser  Thr Ile Asn Phe Ile  Ile Ser Gln 
    1535                 1540                 1545             


Val Ala  Ser Gly Asp Ile Asn  Thr Ser Ile Gln Ala  Leu Thr Gln 
    1550                 1555                 1560             


Ile Asp  Glu Val Leu Arg Gln  Glu Asp Lys Ala Glu  Ala Met Ser 
    1565                 1570                 1575             


Gly His  Ile Asp Gln Phe Leu  Ile Ala Thr Phe Met  Gln Leu Arg 
    1580                 1585                 1590             


Leu Ile  Tyr Asn Thr His Met  Ala Asp Glu Lys Leu  Glu Lys Asp 
    1595                 1600                 1605             


Glu Ile  Ile Lys Leu Tyr Ser  Cys Ile Ile Gly Asn  Met Ile Ser 
    1610                 1615                 1620             


Leu Phe  Gln Ile Glu Ser Leu  Ala Arg Glu Ala Ser  Thr Gly Val 
    1625                 1630                 1635             


Leu Lys  Asp Leu Met His Gly  Leu Ile Thr Leu Met  Leu Asp Ser 
    1640                 1645                 1650             


Arg Ile  Glu Asp Leu Glu Glu  Gly Gln Gln Val Ile  Arg Ser Val 
    1655                 1660                 1665             


Asn Leu  Leu Val Val Lys Val  Leu Glu Lys Ser Asp  Gln Thr Asn 
    1670                 1675                 1680             


Ile Leu  Ser Ala Leu Leu Val  Leu Leu Gln Asp Ser  Leu Leu Ala 
    1685                 1690                 1695             


Thr Ala  Ser Ser Pro Lys Phe  Ser Glu Leu Val Met  Lys Cys Leu 
    1700                 1705                 1710             


Trp Arg  Met Val Arg Leu Leu  Pro Asp Thr Ile Asn  Ser Ile Asn 
    1715                 1720                 1725             


Leu Asp  Arg Ile Leu Leu Asp  Ile His Ile Phe Met  Lys Val Phe 
    1730                 1735                 1740             


Pro Lys  Glu Lys Leu Lys Gln  Cys Lys Ser Glu Phe  Pro Ile Arg 
    1745                 1750                 1755             


Thr Leu  Lys Thr Leu Leu His  Thr Leu Cys Lys Leu  Lys Gly Pro 
    1760                 1765                 1770             


Lys Ile  Leu Asp His Leu Thr  Met Ile Asp Asn Lys  Asn Glu Ser 
    1775                 1780                 1785             


Glu Leu  Glu Ala His Leu Cys  Arg Met Met Lys His  Ser Met Asp 
    1790                 1795                 1800             


Gln Thr  Gly Ser Lys Ser Asp  Lys Glu Thr Glu Lys  Gly Ala Ser 
    1805                 1810                 1815             


Arg Ile  Asp Glu Lys Ser Ser  Lys Ala Lys Val Asn  Asp Phe Leu 
    1820                 1825                 1830             


Ala Glu  Ile Phe Lys Lys Ile  Gly Ser Lys Glu Asn  Thr Lys Glu 
    1835                 1840                 1845             


Gly Leu  Ala Glu Leu Tyr Glu  Tyr Lys Lys Lys Tyr  Ser Asp Ala 
    1850                 1855                 1860             


Asp Ile  Glu Pro Phe Leu Lys  Asn Ser Ser Gln Phe  Phe Gln Ser 
    1865                 1870                 1875             


Tyr Val  Glu Arg Gly Leu Arg  Val Ile Glu Met Glu  Arg Glu Gly 
    1880                 1885                 1890             


Lys Gly  Arg Ile Ser Thr Ser  Thr Gly Ile Ser Pro  Gln Met Glu 
    1895                 1900                 1905             


Val Thr  Cys Val Pro Thr Pro  Thr Ser Thr Val Ser  Ser Ile Gly 
    1910                 1915                 1920             


Asn Thr  Asn Gly Glu Glu Val  Gly Pro Ser Val Tyr  Leu Glu Arg 
    1925                 1930                 1935             


Leu Lys  Ile Leu Arg Gln Arg  Cys Gly Leu Asp Asn  Thr Lys Gln 
    1940                 1945                 1950             


Asp Asp  Arg Pro Pro Leu Thr  Ser Leu Leu Ser Lys  Pro Ala Val 
    1955                 1960                 1965             


Pro Thr  Val Ala Ser Ser Thr  Asp Met Leu His Ser  Lys Leu Ser 
    1970                 1975                 1980             


Gln Leu  Arg Glu Ser Arg Glu  Gln His Gln His Ser  Asp Leu Asp 
    1985                 1990                 1995             


Ser Asn  Gln Thr His Ser Ser  Gly Thr Val Thr Ser  Ser Ser Ser 
    2000                 2005                 2010             


Thr Ala  Asn Ile Asp Asp Leu  Lys Lys Arg Leu Glu  Arg Ile Lys 
    2015                 2020                 2025             


Ser Ser  Arg Lys 
    2030         


<210>  148
<211>  1675
<212>  PRT
<213>  homo sapiens

<400>  148

Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Thr Asp Asp Val Thr Phe Trp Lys 
            100                 105                 110         


Trp Ile Ser Leu Asn Thr Val Ala Leu Val Thr Asp Asn Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys Met Phe Asp Arg 
    130                 135                 140                 


His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr Arg Thr Asp Ala 
145                 150                 155                 160 


Lys Gln Lys Trp Leu Leu Leu Thr Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Glu Glu Ser Thr Leu Phe Cys Phe Ala Val Arg Gly Gln Ala 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Thr Pro Pro Thr Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu Lys His Asp Val 
            260                 265                 270         


Val Phe Leu Ile Thr Lys Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Thr Gly Thr Cys Ile Tyr Met Asn Arg Ile Ser Gly Glu Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Glu Ala Thr Ala Gly Ile Ile Gly Val Asn Arg 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu Asn Ile Ile Pro 
                325                 330                 335     


Tyr Ile Thr Asn Val Leu Gln Asn Pro Asp Leu Ala Leu Arg Met Ala 
            340                 345                 350         


Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe 
        355                 360                 365             


Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Asn Ala Pro Lys Gly Ile Leu Arg Thr Pro Asp Thr Ile Arg Arg 
385                 390                 395                 400 


Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Thr Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Ser Val Asp Pro Thr Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile Ser Pro Asp Gln 
        515                 520                 525             


Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asp Ile Thr Gln Ile Val Asp Val Phe Met Glu Tyr Asn Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ala Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser 
                565                 570                 575     


Glu Gly Pro Leu Gln Thr Arg Leu Leu Glu Met Asn Leu Met His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Arg Ala Leu Glu His Phe Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Ser Thr Gln Ser Leu Ile Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Asn 
            740                 745                 750         


Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Asp Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu Pro Val Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val Ile Lys Asn Leu 
            820                 825                 830         


Ile Leu Val Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala 
    850                 855                 860                 


Arg Ile His Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu 
                885                 890                 895     


Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser 
    930                 935                 940                 


Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp Gly Ser Val Leu 
945                 950                 955                 960 


Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Gln Asp Pro Glu Glu Val Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Asn  Arg Leu Asp Asn Tyr  Asp Ala Pro 
    1040                 1045                 1050             


Asp Ile  Ala Asn Ile Ala Ile  Ser Asn Glu Leu Phe  Glu Glu Ala 
    1055                 1060                 1065             


Phe Ala  Ile Phe Arg Lys Phe  Asp Val Asn Thr Ser  Ala Val Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Lys 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Gly Met  Val Lys Glu Ala Ile  Asp Ser Tyr 
    1115                 1120                 1125             


Ile Lys  Ala Asp Asp Pro Ser  Ser Tyr Met Glu Val  Val Gln Ala 
    1130                 1135                 1140             


Ala Asn  Thr Ser Gly Asn Trp  Glu Glu Leu Val Lys  Tyr Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Ala Arg  Glu Ser Tyr Val Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Asn Arg Leu Ala Glu  Leu Glu Glu 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Asp Glu Lys Met  Tyr Asp Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Asn Asn  Val Ser Asn Phe Gly  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Gly Ala Arg  Lys Ala Asn 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Val Asp Gly 
    1250                 1255                 1260             


Lys Glu  Phe Arg Leu Ala Gln  Met Cys Gly Leu His  Ile Val Val 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Ile Asn Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Thr Met Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Arg Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Ile  Ile Thr Met Met Asn  His Pro Thr 
    1370                 1375                 1380             


Asp Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Tyr Tyr  Arg Ala Ile Gln Phe  Tyr Leu Glu 
    1400                 1405                 1410             


Phe Lys  Pro Leu Leu Leu Asn  Asp Leu Leu Met Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Arg Ala  Val Asn Tyr Phe Ser  Lys Val Lys 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Asn His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ser Leu Asn Asn Leu  Phe Ile Thr 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Ala Leu  Arg Thr Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Arg Leu Glu  Lys His Glu 
    1490                 1495                 1500             


Leu Ile  Glu Phe Arg Arg Ile  Ala Ala Tyr Leu Phe  Lys Gly Asn 
    1505                 1510                 1515             


Asn Arg  Trp Lys Gln Ser Val  Glu Leu Cys Lys Lys  Asp Ser Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln Tyr  Ala Ser Glu Ser Lys  Asp Thr Glu 
    1535                 1540                 1545             


Leu Ala  Glu Glu Leu Leu Gln  Trp Phe Leu Gln Glu  Glu Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Gly Ala Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Val Val Leu Glu Thr  Ala Trp Arg His Asn  Ile Met Asp 
    1580                 1585                 1590             


Phe Ala  Met Pro Tyr Phe Ile  Gln Val Met Lys Glu  Tyr Leu Thr 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Ser Glu Ser Leu Arg  Lys Glu Glu 
    1610                 1615                 1620             


Glu Gln  Ala Thr Glu Thr Gln  Pro Ile Val Tyr Gly  Gln Pro Gln 
    1625                 1630                 1635             


Leu Met  Leu Thr Ala Gly Pro  Ser Val Ala Val Pro  Pro Gln Ala 
    1640                 1645                 1650             


Pro Phe  Gly Tyr Gly Tyr Thr  Ala Pro Pro Tyr Gly  Gln Pro Gln 
    1655                 1660                 1665             


Pro Gly  Phe Gly Tyr Ser Met  
    1670                 1675 


<210>  149
<211>  1865
<212>  PRT
<213>  homo sapiens

<400>  149

Met Thr Arg Trp Val Pro Thr Lys Arg Glu Glu Lys Tyr Gly Val Ala 
1               5                   10                  15      


Phe Tyr Asn Tyr Asp Ala Arg Gly Ala Asp Glu Leu Ser Leu Gln Ile 
            20                  25                  30          


Gly Asp Thr Val His Ile Leu Glu Thr Tyr Glu Gly Trp Tyr Arg Gly 
        35                  40                  45              


Tyr Thr Leu Arg Lys Lys Ser Lys Lys Gly Ile Phe Pro Ala Ser Tyr 
    50                  55                  60                  


Ile His Leu Lys Glu Ala Ile Val Glu Gly Lys Gly Gln His Glu Thr 
65                  70                  75                  80  


Val Ile Pro Gly Asp Leu Pro Leu Ile Gln Glu Val Thr Thr Thr Leu 
                85                  90                  95      


Arg Glu Trp Ser Thr Ile Trp Arg Gln Leu Tyr Val Gln Asp Asn Arg 
            100                 105                 110         


Glu Met Phe Arg Ser Val Arg His Met Ile Tyr Asp Leu Ile Glu Trp 
        115                 120                 125             


Arg Ser Gln Ile Leu Ser Gly Thr Leu Pro Gln Asp Glu Leu Lys Glu 
    130                 135                 140                 


Leu Lys Lys Lys Val Thr Ala Lys Ile Asp Tyr Gly Asn Arg Ile Leu 
145                 150                 155                 160 


Asp Leu Asp Leu Val Val Arg Asp Glu Asp Gly Asn Ile Leu Asp Pro 
                165                 170                 175     


Glu Leu Thr Ser Thr Ile Ser Leu Phe Arg Ala His Glu Ile Ala Ser 
            180                 185                 190         


Lys Gln Val Glu Glu Arg Leu Gln Glu Glu Lys Ser Gln Lys Gln Asn 
        195                 200                 205             


Ile Asp Ile Asn Arg Gln Ala Lys Phe Ala Ala Thr Pro Ser Leu Ala 
    210                 215                 220                 


Leu Phe Val Asn Leu Lys Asn Val Val Cys Lys Ile Gly Glu Asp Ala 
225                 230                 235                 240 


Glu Val Leu Met Ser Leu Tyr Asp Pro Val Glu Ser Lys Phe Ile Ser 
                245                 250                 255     


Glu Asn Tyr Leu Val Arg Trp Ser Ser Ser Gly Leu Pro Lys Asp Ile 
            260                 265                 270         


Asp Arg Leu His Asn Leu Arg Ala Val Phe Thr Asp Leu Gly Ser Lys 
        275                 280                 285             


Asp Leu Lys Arg Glu Lys Ile Ser Phe Val Cys Gln Ile Val Arg Val 
    290                 295                 300                 


Gly Arg Met Glu Leu Arg Asp Asn Asn Thr Arg Lys Leu Thr Ser Gly 
305                 310                 315                 320 


Leu Arg Arg Pro Phe Gly Val Ala Val Met Asp Val Thr Asp Ile Ile 
                325                 330                 335     


Asn Gly Lys Val Asp Asp Glu Asp Lys Gln His Phe Ile Pro Phe Gln 
            340                 345                 350         


Pro Val Ala Gly Glu Asn Asp Phe Leu Gln Thr Val Ile Asn Lys Val 
        355                 360                 365             


Ile Ala Ala Lys Glu Val Asn His Lys Gly Gln Gly Leu Trp Val Thr 
    370                 375                 380                 


Leu Lys Leu Leu Pro Gly Asp Ile His Gln Ile Arg Lys Glu Phe Pro 
385                 390                 395                 400 


His Leu Val Asp Arg Thr Thr Ala Val Ala Arg Lys Thr Gly Phe Pro 
                405                 410                 415     


Glu Ile Ile Met Pro Gly Asp Val Arg Asn Asp Ile Tyr Val Thr Leu 
            420                 425                 430         


Val Gln Gly Asp Phe Asp Lys Gly Ser Lys Thr Thr Ala Lys Asn Val 
        435                 440                 445             


Glu Val Thr Val Ser Val Tyr Asp Glu Asp Gly Lys Arg Leu Glu His 
    450                 455                 460                 


Val Ile Phe Pro Gly Ala Gly Asp Glu Ala Ile Ser Glu Tyr Lys Ser 
465                 470                 475                 480 


Val Ile Tyr Tyr Gln Val Lys Gln Pro Arg Trp Phe Glu Thr Val Lys 
                485                 490                 495     


Val Ala Ile Pro Ile Glu Asp Val Asn Arg Ser His Leu Arg Phe Thr 
            500                 505                 510         


Phe Arg His Arg Ser Ser Gln Asp Ser Lys Asp Lys Ser Glu Lys Ile 
        515                 520                 525             


Phe Ala Leu Ala Phe Val Lys Leu Met Arg Tyr Asp Gly Thr Thr Leu 
    530                 535                 540                 


Arg Asp Gly Glu His Asp Leu Ile Val Tyr Lys Ala Glu Ala Lys Lys 
545                 550                 555                 560 


Leu Glu Asp Ala Ala Thr Tyr Leu Ser Leu Pro Ser Thr Lys Ala Glu 
                565                 570                 575     


Leu Glu Glu Lys Gly His Ser Ala Thr Gly Lys Ser Met Gln Ser Leu 
            580                 585                 590         


Gly Ser Cys Thr Ile Ser Lys Asp Ser Phe Gln Ile Ser Thr Leu Val 
        595                 600                 605             


Cys Ser Thr Lys Leu Thr Gln Asn Val Asp Leu Leu Gly Leu Leu Lys 
    610                 615                 620                 


Trp Arg Ser Asn Thr Ser Leu Leu Gln Gln Asn Leu Arg Gln Leu Met 
625                 630                 635                 640 


Lys Val Asp Gly Gly Glu Val Val Lys Phe Leu Gln Asp Thr Leu Asp 
                645                 650                 655     


Ala Leu Phe Asn Ile Met Met Glu Asn Ser Glu Ser Glu Thr Phe Asp 
            660                 665                 670         


Thr Leu Val Phe Asp Ala Leu Val Phe Ile Ile Gly Leu Ile Ala Asp 
        675                 680                 685             


Arg Lys Phe Gln His Phe Asn Pro Val Leu Glu Thr Tyr Ile Lys Lys 
    690                 695                 700                 


His Phe Ser Ala Thr Leu Ala Tyr Thr Lys Leu Thr Lys Val Leu Lys 
705                 710                 715                 720 


Asn Tyr Val Asp Gly Ala Glu Lys Pro Gly Val Asn Glu Gln Leu Tyr 
                725                 730                 735     


Lys Ala Met Lys Ala Leu Glu Ser Ile Phe Lys Phe Ile Val Arg Ser 
            740                 745                 750         


Arg Ile Leu Phe Asn Gln Leu Tyr Glu Asn Lys Gly Glu Ala Asp Phe 
        755                 760                 765             


Val Glu Ser Leu Leu Gln Leu Phe Arg Ser Ile Asn Asp Met Met Ser 
    770                 775                 780                 


Ser Met Ser Asp Gln Thr Val Arg Val Lys Gly Ala Ala Leu Lys Tyr 
785                 790                 795                 800 


Leu Pro Thr Ile Val Asn Asp Val Lys Leu Val Phe Asp Pro Lys Glu 
                805                 810                 815     


Leu Ser Lys Met Phe Thr Glu Phe Ile Leu Asn Val Pro Met Gly Leu 
            820                 825                 830         


Leu Thr Ile Gln Lys Leu Tyr Cys Leu Ile Glu Ile Val His Ser Asp 
        835                 840                 845             


Leu Phe Thr Gln His Asp Cys Arg Glu Ile Leu Leu Pro Met Met Thr 
    850                 855                 860                 


Asp Gln Leu Lys Tyr His Leu Glu Arg Gln Glu Asp Leu Glu Ala Cys 
865                 870                 875                 880 


Cys Gln Leu Leu Ser His Ile Leu Glu Val Leu Tyr Arg Lys Asp Val 
                885                 890                 895     


Gly Pro Thr Gln Arg His Val Gln Ile Ile Met Glu Lys Leu Leu Arg 
            900                 905                 910         


Thr Val Asn Arg Thr Val Ile Ser Met Gly Arg Asp Ser Glu Leu Ile 
        915                 920                 925             


Gly Asn Phe Val Ala Cys Met Thr Ala Ile Leu Arg Gln Met Glu Asp 
    930                 935                 940                 


Tyr His Tyr Ala His Leu Ile Lys Thr Phe Gly Lys Met Arg Thr Asp 
945                 950                 955                 960 


Val Val Asp Phe Leu Met Glu Thr Phe Ile Met Phe Lys Asn Leu Ile 
                965                 970                 975     


Gly Lys Asn Val Tyr Pro Phe Asp Trp Val Ile Met Asn Met Val Gln 
            980                 985                 990         


Asn Lys Val Phe Leu Arg Ala Ile  Asn Gln Tyr Ala Asp  Met Leu Asn 
        995                 1000                 1005             


Lys Lys  Phe Leu Asp Gln Ala  Asn Phe Glu Leu Gln  Leu Trp Asn 
    1010                 1015                 1020             


Asn Tyr  Phe His Leu Ala Val  Ala Phe Leu Thr Gln  Glu Ser Leu 
    1025                 1030                 1035             


Gln Leu  Glu Asn Phe Ser Ser  Ala Lys Arg Ala Lys  Ile Leu Asn 
    1040                 1045                 1050             


Lys Tyr  Gly Asp Met Arg Arg  Gln Ile Gly Phe Glu  Ile Arg Asp 
    1055                 1060                 1065             


Met Trp  Tyr Asn Leu Gly Gln  His Lys Ile Lys Phe  Ile Pro Glu 
    1070                 1075                 1080             


Met Val  Gly Pro Ile Leu Glu  Met Thr Leu Ile Pro  Glu Thr Glu 
    1085                 1090                 1095             


Leu Arg  Lys Ala Thr Ile Pro  Ile Phe Phe Asp Met  Met Gln Cys 
    1100                 1105                 1110             


Glu Phe  His Ser Thr Arg Ser  Phe Gln Met Phe Glu  Asn Glu Ile 
    1115                 1120                 1125             


Ile Thr  Lys Leu Asp His Glu  Val Glu Gly Gly Arg  Gly Asp Glu 
    1130                 1135                 1140             


Gln Tyr  Lys Val Leu Phe Asp  Lys Ile Leu Leu Glu  His Cys Arg 
    1145                 1150                 1155             


Lys His  Lys Tyr Leu Ala Lys  Thr Gly Glu Thr Phe  Val Lys Leu 
    1160                 1165                 1170             


Val Val  Arg Leu Met Glu Arg  Leu Leu Asp Tyr Arg  Thr Ile Met 
    1175                 1180                 1185             


His Asp  Glu Asn Lys Glu Asn  Arg Met Ser Cys Thr  Val Asn Val 
    1190                 1195                 1200             


Leu Asn  Phe Tyr Lys Glu Ile  Glu Arg Glu Glu Met  Tyr Ile Arg 
    1205                 1210                 1215             


Tyr Leu  Tyr Lys Leu Cys Asp  Leu His Lys Glu Cys  Asp Asn Tyr 
    1220                 1225                 1230             


Thr Glu  Ala Ala Tyr Thr Leu  Leu Leu His Ala Lys  Leu Leu Lys 
    1235                 1240                 1245             


Trp Ser  Glu Asp Val Cys Val  Ala His Leu Thr Gln  Arg Asp Gly 
    1250                 1255                 1260             


Tyr Gln  Ala Thr Thr Gln Gly  Gln Leu Lys Glu Gln  Leu Tyr Gln 
    1265                 1270                 1275             


Glu Ile  Ile His Tyr Phe Asp  Lys Gly Lys Met Trp  Glu Glu Ala 
    1280                 1285                 1290             


Ile Ala  Leu Gly Lys Glu Leu  Ala Glu Gln Tyr Glu  Asn Glu Met 
    1295                 1300                 1305             


Phe Asp  Tyr Glu Gln Leu Ser  Glu Leu Leu Lys Lys  Gln Ala Gln 
    1310                 1315                 1320             


Phe Tyr  Glu Asn Ile Val Lys  Val Ile Arg Pro Lys  Pro Asp Tyr 
    1325                 1330                 1335             


Phe Ala  Val Gly Tyr Tyr Gly  Gln Gly Phe Pro Thr  Phe Leu Arg 
    1340                 1345                 1350             


Gly Lys  Val Phe Ile Tyr Arg  Gly Lys Glu Tyr Glu  Arg Arg Glu 
    1355                 1360                 1365             


Asp Phe  Glu Ala Arg Leu Leu  Thr Gln Phe Pro Asn  Ala Glu Lys 
    1370                 1375                 1380             


Met Lys  Thr Thr Ser Pro Pro  Gly Asp Asp Ile Lys  Asn Ser Pro 
    1385                 1390                 1395             


Gly Gln  Tyr Ile Gln Cys Phe  Thr Val Lys Pro Lys  Leu Asp Leu 
    1400                 1405                 1410             


Pro Pro  Lys Phe His Arg Pro  Val Ser Glu Gln Ile  Val Ser Phe 
    1415                 1420                 1425             


Tyr Arg  Val Asn Glu Val Gln  Arg Phe Glu Tyr Ser  Arg Pro Ile 
    1430                 1435                 1440             


Arg Lys  Gly Glu Lys Asn Pro  Asp Asn Glu Phe Ala  Asn Met Trp 
    1445                 1450                 1455             


Ile Glu  Arg Thr Ile Tyr Thr  Thr Ala Tyr Lys Leu  Pro Gly Ile 
    1460                 1465                 1470             


Leu Arg  Trp Phe Glu Val Lys  Ser Val Phe Met Val  Glu Ile Ser 
    1475                 1480                 1485             


Pro Leu  Glu Asn Ala Ile Glu  Thr Met Gln Leu Thr  Asn Asp Lys 
    1490                 1495                 1500             


Ile Asn  Ser Met Val Gln Gln  His Leu Asp Asp Pro  Ser Leu Pro 
    1505                 1510                 1515             


Ile Asn  Pro Leu Ser Met Leu  Leu Asn Gly Ile Val  Asp Pro Ala 
    1520                 1525                 1530             


Val Met  Gly Gly Phe Ala Asn  Tyr Glu Lys Ala Phe  Phe Thr Asp 
    1535                 1540                 1545             


Arg Tyr  Leu Gln Glu His Pro  Glu Ala His Glu Lys  Ile Glu Lys 
    1550                 1555                 1560             


Leu Lys  Asp Leu Ile Ala Trp  Gln Ile Pro Phe Leu  Ala Glu Gly 
    1565                 1570                 1575             


Ile Arg  Ile His Gly Asp Lys  Val Thr Glu Ala Leu  Arg Pro Phe 
    1580                 1585                 1590             


His Glu  Arg Met Glu Ala Cys  Phe Lys Gln Leu Lys  Glu Lys Val 
    1595                 1600                 1605             


Glu Lys  Glu Tyr Gly Val Arg  Ile Met Pro Ser Ser  Leu Asp Asp 
    1610                 1615                 1620             


Arg Arg  Gly Ser Arg Pro Arg  Ser Met Val Arg Ser  Phe Thr Met 
    1625                 1630                 1635             


Pro Ser  Ser Ser Arg Pro Leu  Ser Val Ala Ser Val  Ser Ser Leu 
    1640                 1645                 1650             


Ser Ser  Asp Ser Thr Pro Ser  Arg Pro Gly Ser Asp  Gly Phe Ala 
    1655                 1660                 1665             


Leu Glu  Pro Leu Leu Pro Lys  Lys Met His Ser Arg  Ser Gln Asp 
    1670                 1675                 1680             


Lys Leu  Asp Lys Asp Asp Leu  Glu Lys Glu Lys Lys  Asp Lys Lys 
    1685                 1690                 1695             


Lys Glu  Lys Arg Asn Ser Lys  His Gln Glu Ile Phe  Glu Lys Glu 
    1700                 1705                 1710             


Phe Lys  Pro Thr Asp Ile Ser  Leu Gln Gln Ser Glu  Ala Val Ile 
    1715                 1720                 1725             


Leu Ser  Glu Thr Ile Ser Pro  Leu Arg Pro Gln Arg  Pro Lys Ser 
    1730                 1735                 1740             


Gln Val  Met Asn Val Ile Gly  Ser Glu Arg Arg Phe  Ser Val Ser 
    1745                 1750                 1755             


Pro Ser  Ser Pro Ser Ser Gln  Gln Thr Pro Pro Pro  Val Thr Pro 
    1760                 1765                 1770             


Arg Ala  Lys Leu Ser Phe Ser  Met Gln Ser Ser Leu  Glu Leu Asn 
    1775                 1780                 1785             


Gly Met  Thr Gly Ala Asp Val  Ala Asp Val Pro Pro  Pro Leu Pro 
    1790                 1795                 1800             


Leu Lys  Gly Ser Val Ala Asp  Tyr Gly Asn Leu Met  Glu Asn Gln 
    1805                 1810                 1815             


Asp Leu  Leu Gly Ser Pro Thr  Pro Pro Pro Pro Pro  Pro His Gln 
    1820                 1825                 1830             


Arg His  Leu Pro Pro Pro Leu  Pro Ser Lys Thr Pro  Pro Pro Pro 
    1835                 1840                 1845             


Pro Pro  Lys Thr Thr Arg Lys  Gln Thr Ser Val Asp  Ser Gly Ile 
    1850                 1855                 1860             


Val Gln  
    1865 


<210>  150
<211>  1118
<212>  PRT
<213>  homo sapiens

<400>  150

Met Ala Arg Ser Pro Gly Arg Ala Tyr Ala Leu Leu Leu Leu Leu Ile 
1               5                   10                  15      


Cys Phe Asn Val Gly Ser Gly Leu His Leu Gln Val Leu Ser Thr Arg 
            20                  25                  30          


Asn Glu Asn Lys Leu Leu Pro Lys His Pro His Leu Val Arg Gln Lys 
        35                  40                  45              


Arg Ala Trp Ile Thr Ala Pro Val Ala Leu Arg Glu Gly Glu Asp Leu 
    50                  55                  60                  


Ser Lys Lys Asn Pro Ile Ala Lys Ile His Ser Asp Leu Ala Glu Glu 
65                  70                  75                  80  


Arg Gly Leu Lys Ile Thr Tyr Lys Tyr Thr Gly Lys Gly Ile Thr Glu 
                85                  90                  95      


Pro Pro Phe Gly Ile Phe Val Phe Asn Lys Asp Thr Gly Glu Leu Asn 
            100                 105                 110         


Val Thr Ser Ile Leu Asp Arg Glu Glu Thr Pro Phe Phe Leu Leu Thr 
        115                 120                 125             


Gly Tyr Ala Leu Asp Ala Arg Gly Asn Asn Val Glu Lys Pro Leu Glu 
    130                 135                 140                 


Leu Arg Ile Lys Val Leu Asp Ile Asn Asp Asn Glu Pro Val Phe Thr 
145                 150                 155                 160 


Gln Asp Val Phe Val Gly Ser Val Glu Glu Leu Ser Ala Ala His Thr 
                165                 170                 175     


Leu Val Met Lys Ile Asn Ala Thr Asp Ala Asp Glu Pro Asn Thr Leu 
            180                 185                 190         


Asn Ser Lys Ile Ser Tyr Arg Ile Val Ser Leu Glu Pro Ala Tyr Pro 
        195                 200                 205             


Pro Val Phe Tyr Leu Asn Lys Asp Thr Gly Glu Ile Tyr Thr Thr Ser 
    210                 215                 220                 


Val Thr Leu Asp Arg Glu Glu His Ser Ser Tyr Thr Leu Thr Val Glu 
225                 230                 235                 240 


Ala Arg Asp Gly Asn Gly Glu Val Thr Asp Lys Pro Val Lys Gln Ala 
                245                 250                 255     


Gln Val Gln Ile Arg Ile Leu Asp Val Asn Asp Asn Ile Pro Val Val 
            260                 265                 270         


Glu Asn Lys Val Leu Glu Gly Met Val Glu Glu Asn Gln Val Asn Val 
        275                 280                 285             


Glu Val Thr Arg Ile Lys Val Phe Asp Ala Asp Glu Ile Gly Ser Asp 
    290                 295                 300                 


Asn Trp Leu Ala Asn Phe Thr Phe Ala Ser Gly Asn Glu Gly Gly Tyr 
305                 310                 315                 320 


Phe His Ile Glu Thr Asp Ala Gln Thr Asn Glu Gly Ile Val Thr Leu 
                325                 330                 335     


Ile Lys Glu Val Asp Tyr Glu Glu Met Lys Asn Leu Asp Phe Ser Val 
            340                 345                 350         


Ile Val Ala Asn Lys Ala Ala Phe His Lys Ser Ile Arg Ser Lys Tyr 
        355                 360                 365             


Lys Pro Thr Pro Ile Pro Ile Lys Val Lys Val Lys Asn Val Lys Glu 
    370                 375                 380                 


Gly Ile His Phe Lys Ser Ser Val Ile Ser Ile Tyr Val Ser Glu Ser 
385                 390                 395                 400 


Met Asp Arg Ser Ser Lys Gly Gln Ile Ile Gly Asn Phe Gln Ala Phe 
                405                 410                 415     


Asp Glu Asp Thr Gly Leu Pro Ala His Ala Arg Tyr Val Lys Leu Glu 
            420                 425                 430         


Asp Arg Asp Asn Trp Ile Ser Val Asp Ser Val Thr Ser Glu Ile Lys 
        435                 440                 445             


Leu Ala Lys Leu Pro Asp Phe Glu Ser Arg Tyr Val Gln Asn Gly Thr 
    450                 455                 460                 


Tyr Thr Val Lys Ile Val Ala Ile Ser Glu Asp Tyr Pro Arg Lys Thr 
465                 470                 475                 480 


Ile Thr Gly Thr Val Leu Ile Asn Val Glu Asp Ile Asn Asp Asn Cys 
                485                 490                 495     


Pro Thr Leu Ile Glu Pro Val Gln Thr Ile Cys His Asp Ala Glu Tyr 
            500                 505                 510         


Val Asn Val Thr Ala Glu Asp Leu Asp Gly His Pro Asn Ser Gly Pro 
        515                 520                 525             


Phe Ser Phe Ser Val Ile Asp Lys Pro Pro Gly Met Ala Glu Lys Trp 
    530                 535                 540                 


Lys Ile Ala Arg Gln Glu Ser Thr Ser Val Leu Leu Gln Gln Ser Glu 
545                 550                 555                 560 


Lys Lys Leu Gly Arg Ser Glu Ile Gln Phe Leu Ile Ser Asp Asn Gln 
                565                 570                 575     


Gly Phe Ser Cys Pro Glu Lys Gln Val Leu Thr Leu Thr Val Cys Glu 
            580                 585                 590         


Cys Leu His Gly Ser Gly Cys Arg Glu Ala Gln His Asp Ser Tyr Val 
        595                 600                 605             


Gly Leu Gly Pro Ala Ala Ile Ala Leu Met Ile Leu Ala Phe Leu Leu 
    610                 615                 620                 


Leu Leu Leu Val Pro Leu Leu Leu Leu Met Cys His Cys Gly Lys Gly 
625                 630                 635                 640 


Ala Lys Gly Phe Thr Pro Ile Pro Gly Thr Ile Glu Met Leu His Pro 
                645                 650                 655     


Trp Asn Asn Glu Gly Ala Pro Pro Glu Asp Lys Val Val Pro Ser Phe 
            660                 665                 670         


Leu Pro Val Asp Gln Gly Gly Ser Leu Val Gly Arg Asn Gly Val Gly 
        675                 680                 685             


Gly Met Ala Lys Glu Ala Thr Met Lys Gly Ser Ser Ser Ala Ser Ile 
    690                 695                 700                 


Val Lys Gly Gln His Glu Met Ser Glu Met Asp Gly Arg Trp Glu Glu 
705                 710                 715                 720 


His Arg Ser Leu Leu Ser Gly Arg Ala Thr Gln Phe Thr Gly Ala Thr 
                725                 730                 735     


Gly Ala Ile Met Thr Thr Glu Thr Thr Lys Thr Ala Arg Ala Thr Gly 
            740                 745                 750         


Ala Ser Arg Asp Met Ala Gly Ala Gln Ala Ala Ala Val Ala Leu Asn 
        755                 760                 765             


Glu Glu Phe Leu Arg Asn Tyr Phe Thr Asp Lys Ala Ala Ser Tyr Thr 
    770                 775                 780                 


Glu Glu Asp Glu Asn His Thr Ala Lys Asp Cys Leu Leu Val Tyr Ser 
785                 790                 795                 800 


Gln Glu Glu Thr Glu Ser Leu Asn Ala Ser Ile Gly Cys Cys Ser Phe 
                805                 810                 815     


Ile Glu Gly Glu Leu Asp Asp Arg Phe Leu Asp Asp Leu Gly Leu Lys 
            820                 825                 830         


Phe Lys Thr Leu Ala Glu Val Cys Leu Gly Gln Lys Ile Asp Ile Asn 
        835                 840                 845             


Lys Glu Ile Glu Gln Arg Gln Lys Pro Ala Thr Glu Thr Ser Met Asn 
    850                 855                 860                 


Thr Ala Ser His Ser Leu Cys Glu Gln Thr Met Val Asn Ser Glu Asn 
865                 870                 875                 880 


Thr Tyr Ser Ser Gly Ser Ser Phe Pro Val Pro Lys Ser Leu Gln Glu 
                885                 890                 895     


Ala Asn Ala Glu Lys Val Thr Gln Glu Ile Val Thr Glu Arg Ser Val 
            900                 905                 910         


Ser Ser Arg Gln Ala Gln Lys Val Ala Thr Pro Leu Pro Asp Pro Met 
        915                 920                 925             


Ala Ser Arg Asn Val Ile Ala Thr Glu Thr Ser Tyr Val Thr Gly Ser 
    930                 935                 940                 


Thr Met Pro Pro Thr Thr Val Ile Leu Gly Pro Ser Gln Pro Gln Ser 
945                 950                 955                 960 


Leu Ile Val Thr Glu Arg Val Tyr Ala Pro Ala Ser Thr Leu Val Asp 
                965                 970                 975     


Gln Pro Tyr Ala Asn Glu Gly Thr Val Val Val Thr Glu Arg Val Ile 
            980                 985                 990         


Gln Pro His Gly Gly Gly Ser Asn  Pro Leu Glu Gly Thr  Gln His Leu 
        995                 1000                 1005             


Gln Asp  Val Pro Tyr Val Met  Val Arg Glu Arg Glu  Ser Phe Leu 
    1010                 1015                 1020             


Ala Pro  Ser Ser Gly Val Gln  Pro Thr Leu Ala Met  Pro Asn Ile 
    1025                 1030                 1035             


Ala Val  Gly Gln Asn Val Thr  Val Thr Glu Arg Val  Leu Ala Pro 
    1040                 1045                 1050             


Ala Ser  Thr Leu Gln Ser Ser  Tyr Gln Ile Pro Thr  Glu Asn Ser 
    1055                 1060                 1065             


Met Thr  Ala Arg Asn Thr Thr  Val Ser Gly Ala Gly  Val Pro Gly 
    1070                 1075                 1080             


Pro Leu  Pro Asp Phe Gly Leu  Glu Glu Ser Gly His  Ser Asn Ser 
    1085                 1090                 1095             


Thr Ile  Thr Thr Ser Ser Thr  Arg Val Thr Lys His  Ser Thr Val 
    1100                 1105                 1110             


Gln His  Ser Tyr Ser 
    1115             


<210>  151
<211>  922
<212>  PRT
<213>  homo sapiens

<400>  151

Met Ala Glu Gln Arg Phe Cys Val Asp Tyr Ala Lys Arg Gly Thr Ala 
1               5                   10                  15      


Gly Cys Lys Lys Cys Lys Glu Lys Ile Val Lys Gly Val Cys Arg Ile 
            20                  25                  30          


Gly Lys Val Val Pro Asn Pro Phe Ser Glu Ser Gly Gly Asp Met Lys 
        35                  40                  45              


Glu Trp Tyr His Ile Lys Cys Met Phe Glu Lys Leu Glu Arg Ala Arg 
    50                  55                  60                  


Ala Thr Thr Lys Lys Ile Glu Asp Leu Thr Glu Leu Glu Gly Trp Glu 
65                  70                  75                  80  


Glu Leu Glu Asp Asn Glu Lys Glu Gln Ile Thr Gln His Ile Ala Asp 
                85                  90                  95      


Leu Ser Ser Lys Ala Ala Gly Thr Pro Lys Lys Lys Ala Val Val Gln 
            100                 105                 110         


Ala Lys Leu Thr Thr Thr Gly Gln Val Thr Ser Pro Val Lys Gly Ala 
        115                 120                 125             


Ser Phe Val Thr Ser Thr Asn Pro Arg Lys Phe Ser Gly Phe Ser Ala 
    130                 135                 140                 


Lys Pro Asn Asn Ser Gly Glu Ala Pro Ser Ser Pro Thr Pro Lys Arg 
145                 150                 155                 160 


Ser Leu Ser Ser Ser Lys Cys Asp Pro Arg His Lys Asp Cys Leu Leu 
                165                 170                 175     


Arg Glu Phe Arg Lys Leu Cys Ala Met Val Ala Asp Asn Pro Ser Tyr 
            180                 185                 190         


Asn Thr Lys Thr Gln Ile Ile Gln Asp Phe Leu Arg Lys Gly Ser Ala 
        195                 200                 205             


Gly Asp Gly Phe His Gly Asp Val Tyr Leu Thr Val Lys Leu Leu Leu 
    210                 215                 220                 


Pro Gly Val Ile Lys Thr Val Tyr Asn Leu Asn Asp Lys Gln Ile Val 
225                 230                 235                 240 


Lys Leu Phe Ser Arg Ile Phe Asn Cys Asn Pro Asp Asp Met Ala Arg 
                245                 250                 255     


Asp Leu Glu Gln Gly Asp Val Ser Glu Thr Ile Arg Val Phe Phe Glu 
            260                 265                 270         


Gln Ser Lys Ser Phe Pro Pro Ala Ala Lys Ser Leu Leu Thr Ile Gln 
        275                 280                 285             


Glu Val Asp Glu Phe Leu Leu Arg Leu Ser Lys Leu Thr Lys Glu Asp 
    290                 295                 300                 


Glu Gln Gln Gln Ala Leu Gln Asp Ile Ala Ser Arg Cys Thr Ala Asn 
305                 310                 315                 320 


Asp Leu Lys Cys Ile Ile Arg Leu Ile Lys His Asp Leu Lys Met Asn 
                325                 330                 335     


Ser Gly Ala Lys His Val Leu Asp Ala Leu Asp Pro Asn Ala Tyr Glu 
            340                 345                 350         


Ala Phe Lys Ala Ser Arg Asn Leu Gln Asp Val Val Glu Arg Val Leu 
        355                 360                 365             


His Asn Ala Gln Glu Val Glu Lys Glu Pro Gly Gln Arg Arg Ala Leu 
    370                 375                 380                 


Ser Val Gln Ala Ser Leu Met Thr Pro Val Gln Pro Met Leu Ala Glu 
385                 390                 395                 400 


Ala Cys Lys Ser Val Glu Tyr Ala Met Lys Lys Cys Pro Asn Gly Met 
                405                 410                 415     


Phe Ser Glu Ile Lys Tyr Asp Gly Glu Arg Val Gln Val His Lys Asn 
            420                 425                 430         


Gly Asp His Phe Ser Tyr Phe Ser Arg Ser Leu Lys Pro Val Leu Pro 
        435                 440                 445             


His Lys Val Ala His Phe Lys Asp Tyr Ile Pro Gln Ala Phe Pro Gly 
    450                 455                 460                 


Gly His Ser Met Ile Leu Asp Ser Glu Val Leu Leu Ile Asp Asn Lys 
465                 470                 475                 480 


Thr Gly Lys Pro Leu Pro Phe Gly Thr Leu Gly Val His Lys Lys Ala 
                485                 490                 495     


Ala Phe Gln Asp Ala Asn Val Cys Leu Phe Val Phe Asp Cys Ile Tyr 
            500                 505                 510         


Phe Asn Asp Val Ser Leu Met Asp Arg Pro Leu Cys Glu Arg Arg Lys 
        515                 520                 525             


Phe Leu His Asp Asn Met Val Glu Ile Pro Asn Arg Ile Met Phe Ser 
    530                 535                 540                 


Glu Met Lys Arg Val Thr Lys Ala Leu Asp Leu Ala Asp Met Ile Thr 
545                 550                 555                 560 


Arg Val Ile Gln Glu Gly Leu Glu Gly Leu Val Leu Lys Asp Val Lys 
                565                 570                 575     


Gly Thr Tyr Glu Pro Gly Lys Arg His Trp Leu Lys Val Lys Lys Asp 
            580                 585                 590         


Tyr Leu Asn Glu Gly Ala Met Ala Asp Thr Ala Asp Leu Val Val Leu 
        595                 600                 605             


Gly Ala Phe Tyr Gly Gln Gly Ser Lys Gly Gly Met Met Ser Ile Phe 
    610                 615                 620                 


Leu Met Gly Cys Tyr Asp Pro Gly Ser Gln Lys Trp Cys Thr Val Thr 
625                 630                 635                 640 


Lys Cys Ala Gly Gly His Asp Asp Ala Thr Leu Ala Arg Leu Gln Asn 
                645                 650                 655     


Glu Leu Asp Met Val Lys Ile Ser Lys Asp Pro Ser Lys Ile Pro Ser 
            660                 665                 670         


Trp Leu Lys Val Asn Lys Ile Tyr Tyr Pro Asp Phe Ile Val Pro Asp 
        675                 680                 685             


Pro Lys Lys Ala Ala Val Trp Glu Ile Thr Gly Ala Glu Phe Ser Lys 
    690                 695                 700                 


Ser Glu Ala His Thr Ala Asp Gly Ile Ser Ile Arg Phe Pro Arg Cys 
705                 710                 715                 720 


Thr Arg Ile Arg Asp Asp Lys Asp Trp Lys Ser Ala Thr Asn Leu Pro 
                725                 730                 735     


Gln Leu Lys Glu Leu Tyr Gln Leu Ser Lys Glu Lys Ala Asp Phe Thr 
            740                 745                 750         


Val Val Ala Gly Asp Glu Gly Ser Ser Thr Thr Gly Gly Ser Ser Glu 
        755                 760                 765             


Glu Asn Lys Gly Pro Ser Gly Ser Ala Val Ser Arg Lys Ala Pro Ser 
    770                 775                 780                 


Lys Pro Ser Ala Ser Thr Lys Lys Ala Glu Gly Lys Leu Ser Asn Ser 
785                 790                 795                 800 


Asn Ser Lys Asp Gly Asn Met Gln Thr Ala Lys Pro Ser Ala Met Lys 
                805                 810                 815     


Val Gly Glu Lys Leu Ala Thr Lys Ser Ser Pro Val Lys Val Gly Glu 
            820                 825                 830         


Lys Arg Lys Ala Ala Asp Glu Thr Leu Cys Gln Thr Lys Val Leu Leu 
        835                 840                 845             


Asp Ile Phe Thr Gly Val Arg Leu Tyr Leu Pro Pro Ser Thr Pro Asp 
    850                 855                 860                 


Phe Ser Arg Leu Arg Arg Tyr Phe Val Ala Phe Asp Gly Asp Leu Val 
865                 870                 875                 880 


Gln Glu Phe Asp Met Thr Ser Ala Thr His Val Leu Gly Ser Arg Asp 
                885                 890                 895     


Lys Asn Pro Ala Ala Gln Gln Val Ser Pro Glu Trp Ile Trp Ala Cys 
            900                 905                 910         


Ile Arg Lys Arg Arg Leu Val Ala Pro Cys 
        915                 920         


<210>  152
<211>  1137
<212>  PRT
<213>  homo sapiens

<400>  152

Met Ser Arg Arg Lys Pro Ala Ser Gly Gly Leu Ala Ala Ser Ser Ser 
1               5                   10                  15      


Ala Pro Ala Arg Gln Ala Val Leu Ser Arg Phe Phe Gln Ser Thr Gly 
            20                  25                  30          


Ser Leu Lys Ser Thr Ser Ser Ser Thr Gly Ala Ala Asp Gln Val Asp 
        35                  40                  45              


Pro Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Pro Pro 
    50                  55                  60                  


Ala Pro Pro Ala Pro Ala Phe Pro Pro Gln Leu Pro Pro His Val Ala 
65                  70                  75                  80  


Thr Glu Ile Asp Arg Arg Lys Lys Arg Pro Leu Glu Asn Asp Gly Pro 
                85                  90                  95      


Val Lys Lys Lys Val Lys Lys Val Gln Gln Lys Glu Gly Gly Ser Asp 
            100                 105                 110         


Leu Gly Met Ser Gly Asn Ser Glu Pro Lys Lys Cys Leu Arg Thr Arg 
        115                 120                 125             


Asn Val Ser Lys Ser Leu Glu Lys Leu Lys Glu Phe Cys Cys Asp Ser 
    130                 135                 140                 


Ala Leu Pro Gln Ser Arg Val Gln Thr Glu Ser Leu Gln Glu Arg Phe 
145                 150                 155                 160 


Ala Val Leu Pro Lys Cys Thr Asp Phe Asp Asp Ile Ser Leu Leu His 
                165                 170                 175     


Ala Lys Asn Ala Val Ser Ser Glu Asp Ser Lys Arg Gln Ile Asn Gln 
            180                 185                 190         


Lys Asp Thr Thr Leu Phe Asp Leu Ser Gln Phe Gly Ser Ser Asn Thr 
        195                 200                 205             


Ser His Glu Asn Leu Gln Lys Thr Ala Ser Lys Ser Ala Asn Lys Arg 
    210                 215                 220                 


Ser Lys Ser Ile Tyr Thr Pro Leu Glu Leu Gln Tyr Ile Glu Met Lys 
225                 230                 235                 240 


Gln Gln His Lys Asp Ala Val Leu Cys Val Glu Cys Gly Tyr Lys Tyr 
                245                 250                 255     


Arg Phe Phe Gly Glu Asp Ala Glu Ile Ala Ala Arg Glu Leu Asn Ile 
            260                 265                 270         


Tyr Cys His Leu Asp His Asn Phe Met Thr Ala Ser Ile Pro Thr His 
        275                 280                 285             


Arg Leu Phe Val His Val Arg Arg Leu Val Ala Lys Gly Tyr Lys Val 
    290                 295                 300                 


Gly Val Val Lys Gln Thr Glu Thr Ala Ala Leu Lys Ala Ile Gly Asp 
305                 310                 315                 320 


Asn Arg Ser Ser Leu Phe Ser Arg Lys Leu Thr Ala Leu Tyr Thr Lys 
                325                 330                 335     


Ser Thr Leu Ile Gly Glu Asp Val Asn Pro Leu Ile Lys Leu Asp Asp 
            340                 345                 350         


Ala Val Asn Val Asp Glu Ile Met Thr Asp Thr Ser Thr Ser Tyr Leu 
        355                 360                 365             


Leu Cys Ile Ser Glu Asn Lys Glu Asn Val Arg Asp Lys Lys Lys Gly 
    370                 375                 380                 


Asn Ile Phe Ile Gly Ile Val Gly Val Gln Pro Ala Thr Gly Glu Val 
385                 390                 395                 400 


Val Phe Asp Ser Phe Gln Asp Ser Ala Ser Arg Ser Glu Leu Glu Thr 
                405                 410                 415     


Arg Met Ser Ser Leu Gln Pro Val Glu Leu Leu Leu Pro Ser Ala Leu 
            420                 425                 430         


Ser Glu Gln Thr Glu Ala Leu Ile His Arg Ala Thr Ser Val Ser Val 
        435                 440                 445             


Gln Asp Asp Arg Ile Arg Val Glu Arg Met Asp Asn Ile Tyr Phe Glu 
    450                 455                 460                 


Tyr Ser His Ala Phe Gln Ala Val Thr Glu Phe Tyr Ala Lys Asp Thr 
465                 470                 475                 480 


Val Asp Ile Lys Gly Ser Gln Ile Ile Ser Gly Ile Val Asn Leu Glu 
                485                 490                 495     


Lys Pro Val Ile Cys Ser Leu Ala Ala Ile Ile Lys Tyr Leu Lys Glu 
            500                 505                 510         


Phe Asn Leu Glu Lys Met Leu Ser Lys Pro Glu Asn Phe Lys Gln Leu 
        515                 520                 525             


Ser Ser Lys Met Glu Phe Met Thr Ile Asn Gly Thr Thr Leu Arg Asn 
    530                 535                 540                 


Leu Glu Ile Leu Gln Asn Gln Thr Asp Met Lys Thr Lys Gly Ser Leu 
545                 550                 555                 560 


Leu Trp Val Leu Asp His Thr Lys Thr Ser Phe Gly Arg Arg Lys Leu 
                565                 570                 575     


Lys Lys Trp Val Thr Gln Pro Leu Leu Lys Leu Arg Glu Ile Asn Ala 
            580                 585                 590         


Arg Leu Asp Ala Val Ser Glu Val Leu His Ser Glu Ser Ser Val Phe 
        595                 600                 605             


Gly Gln Ile Glu Asn His Leu Arg Lys Leu Pro Asp Ile Glu Arg Gly 
    610                 615                 620                 


Leu Cys Ser Ile Tyr His Lys Lys Cys Ser Thr Gln Glu Phe Phe Leu 
625                 630                 635                 640 


Ile Val Lys Thr Leu Tyr His Leu Lys Ser Glu Phe Gln Ala Ile Ile 
                645                 650                 655     


Pro Ala Val Asn Ser His Ile Gln Ser Asp Leu Leu Arg Thr Val Ile 
            660                 665                 670         


Leu Glu Ile Pro Glu Leu Leu Ser Pro Val Glu His Tyr Leu Lys Ile 
        675                 680                 685             


Leu Asn Glu Gln Ala Ala Lys Val Gly Asp Lys Thr Glu Leu Phe Lys 
    690                 695                 700                 


Asp Leu Ser Asp Phe Pro Leu Ile Lys Lys Arg Lys Asp Glu Ile Gln 
705                 710                 715                 720 


Gly Val Ile Asp Glu Ile Arg Met His Leu Gln Glu Ile Arg Lys Ile 
                725                 730                 735     


Leu Lys Asn Pro Ser Ala Gln Tyr Val Thr Val Ser Gly Gln Glu Phe 
            740                 745                 750         


Met Ile Glu Ile Lys Asn Ser Ala Val Ser Cys Ile Pro Thr Asp Trp 
        755                 760                 765             


Val Lys Val Gly Ser Thr Lys Ala Val Ser Arg Phe His Ser Pro Phe 
    770                 775                 780                 


Ile Val Glu Asn Tyr Arg His Leu Asn Gln Leu Arg Glu Gln Leu Val 
785                 790                 795                 800 


Leu Asp Cys Ser Ala Glu Trp Leu Asp Phe Leu Glu Lys Phe Ser Glu 
                805                 810                 815     


His Tyr His Ser Leu Cys Lys Ala Val His His Leu Ala Thr Val Asp 
            820                 825                 830         


Cys Ile Phe Ser Leu Ala Lys Val Ala Lys Gln Gly Asp Tyr Cys Arg 
        835                 840                 845             


Pro Thr Val Gln Glu Glu Arg Lys Ile Val Ile Lys Asn Gly Arg His 
    850                 855                 860                 


Pro Val Ile Asp Val Leu Leu Gly Glu Gln Asp Gln Tyr Val Pro Asn 
865                 870                 875                 880 


Asn Thr Asp Leu Ser Glu Asp Ser Glu Arg Val Met Ile Ile Thr Gly 
                885                 890                 895     


Pro Asn Met Gly Gly Lys Ser Ser Tyr Ile Lys Gln Val Ala Leu Ile 
            900                 905                 910         


Thr Ile Met Ala Gln Ile Gly Ser Tyr Val Pro Ala Glu Glu Ala Thr 
        915                 920                 925             


Ile Gly Ile Val Asp Gly Ile Phe Thr Arg Met Gly Ala Ala Asp Asn 
    930                 935                 940                 


Ile Tyr Lys Gly Arg Ser Thr Phe Met Glu Glu Leu Thr Asp Thr Ala 
945                 950                 955                 960 


Glu Ile Ile Arg Lys Ala Thr Ser Gln Ser Leu Val Ile Leu Asp Glu 
                965                 970                 975     


Leu Gly Arg Gly Thr Ser Thr His Asp Gly Ile Ala Ile Ala Tyr Ala 
            980                 985                 990         


Thr Leu Glu Tyr Phe Ile Arg Asp  Val Lys Ser Leu Thr  Leu Phe Val 
        995                 1000                 1005             


Thr His  Tyr Pro Pro Val Cys  Glu Leu Glu Lys Asn  Tyr Ser His 
    1010                 1015                 1020             


Gln Val  Gly Asn Tyr His Met  Gly Phe Leu Val Ser  Glu Asp Glu 
    1025                 1030                 1035             


Ser Lys  Leu Asp Pro Gly Thr  Ala Glu Gln Val Pro  Asp Phe Val 
    1040                 1045                 1050             


Thr Phe  Leu Tyr Gln Ile Thr  Arg Gly Ile Ala Ala  Arg Ser Tyr 
    1055                 1060                 1065             


Gly Leu  Asn Val Ala Lys Leu  Ala Asp Val Pro Gly  Glu Ile Leu 
    1070                 1075                 1080             


Lys Lys  Ala Ala His Lys Ser  Lys Glu Leu Glu Gly  Leu Ile Asn 
    1085                 1090                 1095             


Thr Lys  Arg Lys Arg Leu Lys  Tyr Phe Ala Lys Leu  Trp Thr Met 
    1100                 1105                 1110             


His Asn  Ala Gln Asp Leu Gln  Lys Trp Thr Glu Glu  Phe Asn Met 
    1115                 1120                 1125             


Glu Glu  Thr Gln Thr Ser Leu  Leu His 
    1130                 1135         


<210>  153
<211>  3130
<212>  PRT
<213>  homo sapiens

<400>  153

Met Phe Ser Val Arg Ile Val Thr Ala Asp Tyr Tyr Met Ala Ser Pro 
1               5                   10                  15      


Leu Gln Gly Leu Asp Thr Cys Gln Ser Pro Leu Thr Gln Ala Pro Val 
            20                  25                  30          


Lys Lys Val Pro Val Val Arg Val Phe Gly Ala Thr Pro Ala Gly Gln 
        35                  40                  45              


Lys Thr Cys Leu His Leu His Gly Ile Phe Pro Tyr Leu Tyr Val Pro 
    50                  55                  60                  


Tyr Asp Gly Tyr Gly Gln Gln Pro Glu Ser Tyr Leu Ser Gln Met Ala 
65                  70                  75                  80  


Phe Ser Ile Asp Arg Ala Leu Asn Val Ala Leu Gly Asn Pro Ser Ser 
                85                  90                  95      


Thr Ala Gln His Val Phe Lys Val Ser Leu Val Ser Gly Met Pro Phe 
            100                 105                 110         


Tyr Gly Tyr His Glu Lys Glu Arg His Phe Met Lys Ile Tyr Leu Tyr 
        115                 120                 125             


Asn Pro Thr Met Val Lys Arg Ile Cys Glu Leu Leu Gln Ser Gly Ala 
    130                 135                 140                 


Ile Met Asn Lys Phe Tyr Gln Pro His Glu Ala His Ile Pro Tyr Leu 
145                 150                 155                 160 


Leu Gln Leu Phe Ile Asp Tyr Asn Leu Tyr Gly Met Asn Leu Ile Asn 
                165                 170                 175     


Leu Ala Ala Val Lys Phe Arg Lys Ala Arg Arg Lys Ser Asn Thr Leu 
            180                 185                 190         


His Ala Thr Gly Ser Cys Lys Asn His Leu Ser Gly Asn Ser Leu Ala 
        195                 200                 205             


Asp Thr Leu Phe Arg Trp Glu Gln Asp Glu Ile Pro Ser Ser Leu Ile 
    210                 215                 220                 


Leu Glu Gly Val Glu Pro Gln Ser Thr Cys Glu Leu Glu Val Asp Ala 
225                 230                 235                 240 


Val Ala Ala Asp Ile Leu Asn Arg Leu Asp Ile Glu Ala Gln Ile Gly 
                245                 250                 255     


Gly Asn Pro Gly Leu Gln Ala Ile Trp Glu Asp Glu Lys Gln Arg Arg 
            260                 265                 270         


Arg Asn Arg Asn Glu Thr Ser Gln Met Ser Gln Pro Glu Ser Gln Asp 
        275                 280                 285             


His Arg Phe Val Pro Ala Thr Glu Ser Glu Lys Lys Phe Gln Lys Arg 
    290                 295                 300                 


Leu Gln Glu Ile Leu Lys Gln Asn Asp Phe Ser Val Thr Leu Ser Gly 
305                 310                 315                 320 


Ser Val Asp Tyr Ser Asp Gly Ser Gln Glu Phe Ser Ala Glu Leu Thr 
                325                 330                 335     


Leu His Ser Glu Val Leu Ser Pro Glu Met Leu Gln Cys Thr Pro Ala 
            340                 345                 350         


Asn Met Val Glu Val His Lys Asp Lys Glu Ser Ser Lys Gly His Thr 
        355                 360                 365             


Arg His Lys Val Glu Glu Ala Leu Ile Asn Glu Glu Ala Ile Leu Asn 
    370                 375                 380                 


Leu Met Glu Asn Ser Gln Thr Phe Gln Pro Leu Thr Gln Arg Leu Ser 
385                 390                 395                 400 


Glu Ser Pro Val Phe Met Asp Ser Ser Pro Asp Glu Ala Leu Val His 
                405                 410                 415     


Leu Leu Ala Gly Leu Glu Ser Asp Gly Tyr Arg Gly Glu Arg Asn Arg 
            420                 425                 430         


Met Pro Ser Pro Cys Arg Ser Phe Gly Asn Asn Lys Tyr Pro Gln Asn 
        435                 440                 445             


Ser Asp Asp Glu Glu Asn Glu Pro Gln Ile Glu Lys Glu Glu Met Glu 
    450                 455                 460                 


Leu Ser Leu Val Met Ser Gln Arg Trp Asp Ser Asn Ile Glu Glu His 
465                 470                 475                 480 


Cys Ala Lys Lys Arg Ser Leu Cys Arg Asn Thr His Arg Ser Ser Thr 
                485                 490                 495     


Glu Asp Asp Asp Ser Ser Ser Gly Glu Glu Met Glu Trp Ser Asp Asn 
            500                 505                 510         


Ser Leu Leu Leu Ala Ser Leu Ser Ile Pro Gln Leu Asp Gly Thr Ala 
        515                 520                 525             


Asp Glu Asn Ser Asp Asn Pro Leu Asn Asn Glu Asn Ser Arg Thr His 
    530                 535                 540                 


Ser Ser Val Ile Ala Thr Ser Lys Leu Ser Val Lys Pro Ser Ile Phe 
545                 550                 555                 560 


His Lys Asp Ala Ala Thr Leu Glu Pro Ser Ser Ser Ala Lys Ile Thr 
                565                 570                 575     


Phe Gln Cys Lys His Thr Ser Ala Leu Ser Ser His Val Leu Asn Lys 
            580                 585                 590         


Glu Asp Leu Ile Glu Asp Leu Ser Gln Thr Asn Lys Asn Thr Glu Lys 
        595                 600                 605             


Gly Leu Asp Asn Ser Val Thr Ser Phe Thr Asn Glu Ser Thr Tyr Ser 
    610                 615                 620                 


Met Lys Tyr Pro Gly Ser Leu Ser Ser Thr Val His Ser Glu Asn Ser 
625                 630                 635                 640 


His Lys Glu Asn Ser Lys Lys Glu Ile Leu Pro Val Ser Ser Cys Glu 
                645                 650                 655     


Ser Ser Ile Phe Asp Tyr Glu Glu Asp Ile Pro Ser Val Thr Arg Gln 
            660                 665                 670         


Val Pro Ser Arg Lys Tyr Thr Asn Ile Arg Lys Ile Glu Lys Asp Ser 
        675                 680                 685             


Pro Phe Ile His Met His Arg His Pro Asn Glu Asn Thr Leu Gly Lys 
    690                 695                 700                 


Asn Ser Phe Asn Phe Ser Asp Leu Asn His Ser Lys Asn Lys Val Ser 
705                 710                 715                 720 


Ser Glu Gly Asn Glu Lys Gly Asn Ser Thr Ala Leu Ser Ser Leu Phe 
                725                 730                 735     


Pro Ser Ser Phe Thr Glu Asn Cys Glu Leu Leu Ser Cys Ser Gly Glu 
            740                 745                 750         


Asn Arg Thr Met Val His Ser Leu Asn Ser Thr Ala Asp Glu Ser Gly 
        755                 760                 765             


Leu Asn Lys Leu Lys Ile Arg Tyr Glu Glu Phe Gln Glu His Lys Thr 
    770                 775                 780                 


Glu Lys Pro Ser Leu Ser Gln Gln Ala Ala His Tyr Met Phe Phe Pro 
785                 790                 795                 800 


Ser Val Val Leu Ser Asn Cys Leu Thr Arg Pro Gln Lys Leu Ser Pro 
                805                 810                 815     


Val Thr Tyr Lys Leu Gln Pro Gly Asn Lys Pro Ser Arg Leu Lys Leu 
            820                 825                 830         


Asn Lys Arg Lys Leu Ala Gly His Gln Glu Thr Ser Thr Lys Ser Ser 
        835                 840                 845             


Glu Thr Gly Ser Thr Lys Asp Asn Phe Ile Gln Asn Asn Pro Cys Asn 
    850                 855                 860                 


Ser Asn Pro Glu Lys Asp Asn Ala Leu Ala Ser Asp Leu Thr Lys Thr 
865                 870                 875                 880 


Thr Arg Gly Ala Phe Glu Asn Lys Thr Pro Thr Asp Gly Phe Ile Asp 
                885                 890                 895     


Cys His Phe Gly Asp Gly Thr Leu Glu Thr Glu Gln Ser Phe Gly Leu 
            900                 905                 910         


Tyr Gly Asn Lys Tyr Thr Leu Arg Ala Lys Arg Lys Val Asn Tyr Glu 
        915                 920                 925             


Thr Glu Asp Ser Glu Ser Ser Phe Val Thr His Asn Ser Lys Ile Ser 
    930                 935                 940                 


Leu Pro His Pro Met Glu Ile Gly Glu Ser Leu Asp Gly Thr Leu Lys 
945                 950                 955                 960 


Ser Arg Lys Arg Arg Lys Met Ser Lys Lys Leu Pro Pro Val Ile Ile 
                965                 970                 975     


Lys Tyr Ile Ile Ile Asn Arg Phe Arg Gly Arg Lys Asn Met Leu Val 
            980                 985                 990         


Lys Leu Gly Lys Ile Asp Ser Lys  Glu Lys Gln Val Ile  Leu Thr Glu 
        995                 1000                 1005             


Glu Lys  Met Glu Leu Tyr Lys  Lys Leu Ala Pro Leu  Lys Asp Phe 
    1010                 1015                 1020             


Trp Pro  Lys Val Pro Asp Ser  Pro Ala Thr Lys Tyr  Pro Ile Tyr 
    1025                 1030                 1035             


Pro Leu  Thr Pro Lys Lys Ser  His Arg Arg Lys Ser  Lys His Lys 
    1040                 1045                 1050             


Ser Ala  Lys Lys Lys Thr Gly  Lys Gln Gln Arg Thr  Asn Asn Glu 
    1055                 1060                 1065             


Asn Ile  Lys Arg Thr Leu Ser  Phe Arg Lys Lys Arg  Ser His Ala 
    1070                 1075                 1080             


Ile Leu  Ser Pro Pro Ser Pro  Ser Tyr Asn Ala Glu  Thr Glu Asp 
    1085                 1090                 1095             


Cys Asp  Leu Asn Tyr Ser Asp  Val Met Ser Lys Leu  Gly Phe Leu 
    1100                 1105                 1110             


Ser Glu  Arg Ser Thr Ser Pro  Ile Asn Ser Ser Pro  Pro Arg Cys 
    1115                 1120                 1125             


Trp Ser  Pro Thr Asp Pro Arg  Ala Glu Glu Ile Met  Ala Ala Ala 
    1130                 1135                 1140             


Glu Lys  Glu Ala Met Leu Phe  Lys Gly Pro Asn Val  Tyr Lys Lys 
    1145                 1150                 1155             


Thr Val  Asn Ser Arg Ile Gly  Lys Thr Ser Arg Ala  Arg Ala Gln 
    1160                 1165                 1170             


Ile Lys  Lys Ser Lys Ala Lys  Leu Ala Asn Pro Ser  Ile Val Thr 
    1175                 1180                 1185             


Lys Lys  Arg Asn Lys Arg Asn  Gln Thr Asn Lys Leu  Val Asp Asp 
    1190                 1195                 1200             


Gly Lys  Lys Lys Pro Arg Ala  Lys Gln Lys Thr Asn  Glu Lys Gly 
    1205                 1210                 1215             


Thr Ser  Arg Lys His Thr Thr  Leu Lys Asp Glu Lys  Ile Lys Ser 
    1220                 1225                 1230             


Gln Ser  Gly Ala Glu Val Lys  Phe Val Leu Lys His  Gln Asn Val 
    1235                 1240                 1245             


Ser Glu  Phe Ala Ser Ser Ser  Gly Gly Ser Gln Leu  Leu Phe Lys 
    1250                 1255                 1260             


Gln Lys  Asp Met Pro Leu Met  Gly Ser Ala Val Asp  His Pro Leu 
    1265                 1270                 1275             


Ser Ala  Ser Leu Pro Thr Gly  Ile Asn Ala Gln Gln  Lys Leu Ser 
    1280                 1285                 1290             


Gly Cys  Phe Ser Ser Phe Leu  Glu Ser Lys Lys Ser  Val Asp Leu 
    1295                 1300                 1305             


Gln Thr  Phe Pro Ser Ser Arg  Asp Asp Leu His Pro  Ser Val Val 
    1310                 1315                 1320             


Cys Asn  Ser Ile Gly Pro Gly  Val Ser Lys Ile Asn  Val Gln Arg 
    1325                 1330                 1335             


Pro His  Asn Gln Ser Ala Met  Phe Thr Leu Lys Glu  Ser Thr Leu 
    1340                 1345                 1350             


Ile Gln  Lys Asn Ile Phe Asp  Leu Ser Asn His Leu  Ser Gln Val 
    1355                 1360                 1365             


Ala Gln  Asn Thr Gln Ile Ser  Ser Gly Met Ser Ser  Lys Ile Glu 
    1370                 1375                 1380             


Asp Asn  Ala Asn Asn Ile Gln  Arg Asn Tyr Leu Ser  Ser Ile Gly 
    1385                 1390                 1395             


Lys Leu  Ser Glu Tyr Arg Asn  Ser Leu Glu Ser Lys  Leu Asp Gln 
    1400                 1405                 1410             


Ala Tyr  Thr Pro Asn Phe Leu  His Cys Lys Asp Ser  Gln Gln Gln 
    1415                 1420                 1425             


Ile Val  Cys Ile Ala Glu Gln  Ser Lys His Ser Glu  Thr Cys Ser 
    1430                 1435                 1440             


Pro Gly  Asn Thr Ala Ser Glu  Glu Ser Gln Met Pro  Asn Asn Cys 
    1445                 1450                 1455             


Phe Val  Thr Ser Leu Arg Ser  Pro Ile Lys Gln Ile  Ala Trp Glu 
    1460                 1465                 1470             


Gln Lys  Gln Arg Gly Phe Ile  Leu Asp Met Ser Asn  Phe Lys Pro 
    1475                 1480                 1485             


Glu Arg  Val Lys Pro Arg Ser  Leu Ser Glu Ala Ile  Ser Gln Thr 
    1490                 1495                 1500             


Lys Ala  Leu Ser Gln Cys Lys  Asn Arg Asn Val Ser  Thr Pro Ser 
    1505                 1510                 1515             


Ala Phe  Gly Glu Gly Gln Ser  Gly Leu Ala Val Leu  Lys Glu Leu 
    1520                 1525                 1530             


Leu Gln  Lys Arg Gln Gln Lys  Ala Gln Asn Ala Asn  Thr Thr Gln 
    1535                 1540                 1545             


Asp Pro  Leu Ser Asn Lys His  Gln Pro Asn Lys Asn  Ile Ser Gly 
    1550                 1555                 1560             


Ser Leu  Glu His Asn Lys Ala  Asn Lys Arg Thr Arg  Ser Val Thr 
    1565                 1570                 1575             


Ser Pro  Arg Lys Pro Arg Thr  Pro Arg Ser Thr Lys  Gln Lys Glu 
    1580                 1585                 1590             


Lys Ile  Pro Lys Leu Leu Lys  Val Asp Ser Leu Asn  Leu Gln Asn 
    1595                 1600                 1605             


Ser Ser  Gln Leu Asp Asn Ser  Val Ser Asp Asp Ser  Pro Ile Phe 
    1610                 1615                 1620             


Phe Ser  Asp Pro Gly Phe Glu  Ser Cys Tyr Ser Leu  Glu Asp Ser 
    1625                 1630                 1635             


Leu Ser  Pro Glu His Asn Tyr  Asn Phe Asp Ile Asn  Thr Ile Gly 
    1640                 1645                 1650             


Gln Thr  Gly Phe Cys Ser Phe  Tyr Ser Gly Ser Gln  Phe Val Pro 
    1655                 1660                 1665             


Ala Asp  Gln Asn Leu Pro Gln  Lys Phe Leu Ser Asp  Ala Val Gln 
    1670                 1675                 1680             


Asp Leu  Phe Pro Gly Gln Ala  Ile Glu Lys Asn Glu  Phe Leu Ser 
    1685                 1690                 1695             


His Asp  Asn Gln Lys Cys Asp  Glu Asp Lys His His  Thr Thr Asp 
    1700                 1705                 1710             


Ser Ala  Ser Trp Ile Arg Ser  Gly Thr Leu Ser Pro  Glu Ile Phe 
    1715                 1720                 1725             


Glu Lys  Ser Thr Ile Asp Ser  Asn Glu Asn Arg Arg  His Asn Gln 
    1730                 1735                 1740             


Trp Lys  Asn Ser Phe His Pro  Leu Thr Thr Arg Ser  Asn Ser Ile 
    1745                 1750                 1755             


Met Asp  Ser Phe Cys Val Gln  Gln Ala Glu Asp Cys  Leu Ser Glu 
    1760                 1765                 1770             


Lys Ser  Arg Leu Asn Arg Ser  Ser Val Ser Lys Glu  Val Phe Leu 
    1775                 1780                 1785             


Ser Leu  Pro Gln Pro Asn Asn  Ser Asp Trp Ile Gln  Gly His Thr 
    1790                 1795                 1800             


Arg Lys  Glu Met Gly Gln Ser  Leu Asp Ser Ala Asn  Thr Ser Phe 
    1805                 1810                 1815             


Thr Ala  Ile Leu Ser Ser Pro  Asp Gly Glu Leu Val  Asp Val Ala 
    1820                 1825                 1830             


Cys Glu  Asp Leu Glu Leu Tyr  Val Ser Arg Asn Asn  Asp Met Leu 
    1835                 1840                 1845             


Thr Pro  Thr Pro Asp Ser Ser  Pro Arg Ser Thr Ser  Ser Pro Ser 
    1850                 1855                 1860             


Gln Ser  Lys Asn Gly Ser Phe  Thr Pro Arg Thr Ala  Asn Ile Leu 
    1865                 1870                 1875             


Lys Pro  Leu Met Ser Pro Pro  Ser Arg Glu Glu Ile  Met Ala Thr 
    1880                 1885                 1890             


Leu Leu  Asp His Asp Leu Ser  Glu Thr Ile Tyr Gln  Glu Pro Phe 
    1895                 1900                 1905             


Cys Ser  Asn Pro Ser Asp Val  Pro Glu Lys Pro Arg  Glu Ile Gly 
    1910                 1915                 1920             


Gly Arg  Leu Leu Met Val Glu  Thr Arg Leu Ala Asn  Asp Leu Ala 
    1925                 1930                 1935             


Glu Phe  Glu Gly Asp Phe Ser  Leu Glu Gly Leu Arg  Leu Trp Lys 
    1940                 1945                 1950             


Thr Ala  Phe Ser Ala Met Thr  Gln Asn Pro Arg Pro  Gly Ser Pro 
    1955                 1960                 1965             


Leu Arg  Ser Gly Gln Gly Val  Val Asn Lys Gly Ser  Ser Asn Ser 
    1970                 1975                 1980             


Pro Lys  Met Val Glu Asp Lys  Lys Ile Val Ile Met  Pro Cys Lys 
    1985                 1990                 1995             


Cys Ala  Pro Ser Arg Gln Leu  Val Gln Val Trp Leu  Gln Ala Lys 
    2000                 2005                 2010             


Glu Glu  Tyr Glu Arg Ser Lys  Lys Leu Pro Lys Thr  Lys Pro Thr 
    2015                 2020                 2025             


Gly Val  Val Lys Ser Ala Glu  Asn Phe Ser Ser Ser  Val Asn Pro 
    2030                 2035                 2040             


Asp Asp  Lys Pro Val Val Pro  Pro Lys Met Asp Val  Ser Pro Cys 
    2045                 2050                 2055             


Ile Leu  Pro Thr Thr Ala His  Thr Lys Glu Asp Val  Asp Asn Ser 
    2060                 2065                 2070             


Gln Ile  Ala Leu Gln Ala Pro  Thr Thr Gly Cys Ser  Gln Thr Ala 
    2075                 2080                 2085             


Ser Glu  Ser Gln Met Leu Pro  Pro Val Ala Ser Ala  Ser Asp Pro 
    2090                 2095                 2100             


Glu Lys  Asp Glu Asp Asp Asp  Asp Asn Tyr Tyr Ile  Ser Tyr Ser 
    2105                 2110                 2115             


Ser Pro  Asp Ser Pro Val Ile  Pro Pro Trp Gln Gln  Pro Ile Ser 
    2120                 2125                 2130             


Pro Asp  Ser Lys Ala Leu Asn  Gly Asp Asp Arg Pro  Ser Ser Pro 
    2135                 2140                 2145             


Val Glu  Glu Leu Pro Ser Leu  Ala Phe Glu Asn Phe  Leu Lys Pro 
    2150                 2155                 2160             


Ile Lys  Asp Gly Ile Gln Lys  Ser Pro Cys Ser Glu  Pro Gln Glu 
    2165                 2170                 2175             


Pro Leu  Val Ile Ser Pro Ile  Asn Thr Arg Ala Arg  Thr Gly Lys 
    2180                 2185                 2190             


Cys Glu  Ser Leu Cys Phe His  Ser Thr Pro Ile Ile  Gln Arg Lys 
    2195                 2200                 2205             


Leu Leu  Glu Arg Leu Pro Glu  Ala Pro Gly Leu Ser  Pro Leu Ser 
    2210                 2215                 2220             


Thr Glu  Pro Lys Thr Gln Lys  Leu Ser Asn Lys Lys  Gly Ser Asn 
    2225                 2230                 2235             


Thr Asp  Thr Leu Arg Arg Val  Leu Leu Thr Gln Ala  Lys Asn Gln 
    2240                 2245                 2250             


Phe Ala  Ala Val Asn Thr Pro  Gln Lys Glu Thr Ser  Gln Ile Asp 
    2255                 2260                 2265             


Gly Pro  Ser Leu Asn Asn Thr  Tyr Gly Phe Lys Val  Ser Ile Gln 
    2270                 2275                 2280             


Asn Leu  Gln Glu Ala Lys Ala  Leu His Glu Ile Gln  Asn Leu Thr 
    2285                 2290                 2295             


Leu Ile  Ser Val Glu Leu His  Ala Arg Thr Arg Arg  Asp Leu Glu 
    2300                 2305                 2310             


Pro Asp  Pro Glu Phe Asp Pro  Ile Cys Ala Leu Phe  Tyr Cys Ile 
    2315                 2320                 2325             


Ser Ser  Asp Thr Pro Leu Pro  Asp Thr Glu Lys Thr  Glu Leu Thr 
    2330                 2335                 2340             


Gly Val  Ile Val Ile Asp Lys  Asp Lys Thr Val Phe  Ser Gln Asp 
    2345                 2350                 2355             


Ile Arg  Tyr Gln Thr Pro Leu  Leu Ile Arg Ser Gly  Ile Thr Gly 
    2360                 2365                 2370             


Leu Glu  Val Thr Tyr Ala Ala  Asp Glu Lys Ala Leu  Phe His Glu 
    2375                 2380                 2385             


Ile Ala  Asn Ile Ile Lys Arg  Tyr Asp Pro Asp Ile  Leu Leu Gly 
    2390                 2395                 2400             


Tyr Glu  Ile Gln Met His Ser  Trp Gly Tyr Leu Leu  Gln Arg Ala 
    2405                 2410                 2415             


Ala Ala  Leu Ser Ile Asp Leu  Cys Arg Met Ile Ser  Arg Val Pro 
    2420                 2425                 2430             


Asp Asp  Lys Ile Glu Asn Arg  Phe Ala Ala Glu Arg  Asp Glu Tyr 
    2435                 2440                 2445             


Gly Ser  Tyr Thr Met Ser Glu  Ile Asn Ile Val Gly  Arg Ile Thr 
    2450                 2455                 2460             


Leu Asn  Leu Trp Arg Ile Met  Arg Asn Glu Val Ala  Leu Thr Asn 
    2465                 2470                 2475             


Tyr Thr  Phe Glu Asn Val Ser  Phe His Val Leu His  Gln Arg Phe 
    2480                 2485                 2490             


Pro Leu  Phe Thr Phe Arg Val  Leu Ser Asp Trp Phe  Asp Asn Lys 
    2495                 2500                 2505             


Thr Asp  Leu Tyr Arg Trp Lys  Met Val Asp His Tyr  Val Ser Arg 
    2510                 2515                 2520             


Val Arg  Gly Asn Leu Gln Met  Leu Glu Gln Leu Asp  Leu Ile Gly 
    2525                 2530                 2535             


Lys Thr  Ser Glu Met Ala Arg  Leu Phe Gly Ile Gln  Phe Leu His 
    2540                 2545                 2550             


Val Leu  Thr Arg Gly Ser Gln  Tyr Arg Val Glu Ser  Met Met Leu 
    2555                 2560                 2565             


Arg Ile  Ala Lys Pro Met Asn  Tyr Ile Pro Val Thr  Pro Ser Val 
    2570                 2575                 2580             


Gln Gln  Arg Ser Gln Met Arg  Ala Pro Gln Cys Val  Pro Leu Ile 
    2585                 2590                 2595             


Met Glu  Pro Glu Ser Arg Phe  Tyr Ser Asn Ser Val  Leu Val Leu 
    2600                 2605                 2610             


Asp Phe  Gln Ser Leu Tyr Pro  Ser Ile Val Ile Ala  Tyr Asn Tyr 
    2615                 2620                 2625             


Cys Phe  Ser Thr Cys Leu Gly  His Val Glu Asn Leu  Gly Lys Tyr 
    2630                 2635                 2640             


Asp Glu  Phe Lys Phe Gly Cys  Thr Ser Leu Arg Val  Pro Pro Asp 
    2645                 2650                 2655             


Leu Leu  Tyr Gln Val Arg His  Asp Ile Thr Val Ser  Pro Asn Gly 
    2660                 2665                 2670             


Val Ala  Phe Val Lys Pro Ser  Val Arg Lys Gly Val  Leu Pro Arg 
    2675                 2680                 2685             


Met Leu  Glu Glu Ile Leu Lys  Thr Arg Phe Met Val  Lys Gln Ser 
    2690                 2695                 2700             


Met Lys  Ala Tyr Lys Gln Asp  Arg Ala Leu Ser Arg  Met Leu Asp 
    2705                 2710                 2715             


Ala Arg  Gln Leu Gly Leu Lys  Leu Ile Ala Asn Val  Thr Phe Gly 
    2720                 2725                 2730             


Tyr Thr  Ser Ala Asn Phe Ser  Gly Arg Met Pro Cys  Ile Glu Val 
    2735                 2740                 2745             


Gly Asp  Ser Ile Val His Lys  Ala Arg Glu Thr Leu  Glu Arg Ala 
    2750                 2755                 2760             


Ile Lys  Leu Val Asn Asp Thr  Lys Lys Trp Gly Ala  Arg Val Val 
    2765                 2770                 2775             


Tyr Gly  Asp Thr Asp Ser Met  Phe Val Leu Leu Lys  Gly Ala Thr 
    2780                 2785                 2790             


Lys Glu  Gln Ser Phe Lys Ile  Gly Gln Glu Ile Ala  Glu Ala Val 
    2795                 2800                 2805             


Thr Ala  Thr Asn Pro Lys Pro  Val Lys Leu Lys Phe  Glu Lys Val 
    2810                 2815                 2820             


Tyr Leu  Pro Cys Val Leu Gln  Thr Lys Lys Arg Tyr  Val Gly Tyr 
    2825                 2830                 2835             


Met Tyr  Glu Thr Leu Asp Gln  Lys Asp Pro Val Phe  Asp Ala Lys 
    2840                 2845                 2850             


Gly Ile  Glu Thr Val Arg Arg  Asp Ser Cys Pro Ala  Val Ser Lys 
    2855                 2860                 2865             


Ile Leu  Glu Arg Ser Leu Lys  Leu Leu Phe Glu Thr  Arg Asp Ile 
    2870                 2875                 2880             


Ser Leu  Ile Lys Gln Tyr Val  Gln Arg Gln Cys Met  Lys Leu Leu 
    2885                 2890                 2895             


Glu Gly  Lys Ala Ser Ile Gln  Asp Phe Ile Phe Ala  Lys Glu Tyr 
    2900                 2905                 2910             


Arg Gly  Ser Phe Ser Tyr Lys  Pro Gly Ala Cys Val  Pro Ala Leu 
    2915                 2920                 2925             


Glu Leu  Thr Arg Lys Met Leu  Thr Tyr Asp Arg Arg  Ser Glu Pro 
    2930                 2935                 2940             


Gln Val  Gly Glu Arg Val Pro  Tyr Val Ile Ile Tyr  Gly Thr Pro 
    2945                 2950                 2955             


Gly Val  Pro Leu Ile Gln Leu  Val Arg Arg Pro Val  Glu Val Leu 
    2960                 2965                 2970             


Gln Asp  Pro Thr Leu Arg Leu  Asn Ala Thr Tyr Tyr  Ile Thr Lys 
    2975                 2980                 2985             


Gln Ile  Leu Pro Pro Leu Ala  Arg Ile Phe Ser Leu  Ile Gly Ile 
    2990                 2995                 3000             


Asp Val  Phe Ser Trp Tyr His  Glu Leu Pro Arg Ile  His Lys Ala 
    3005                 3010                 3015             


Thr Ser  Ser Ser Arg Ser Glu  Pro Glu Gly Arg Lys  Gly Thr Ile 
    3020                 3025                 3030             


Ser Gln  Tyr Phe Thr Thr Leu  His Cys Pro Val Cys  Asp Asp Leu 
    3035                 3040                 3045             


Thr Gln  His Gly Ile Cys Ser  Lys Cys Arg Ser Gln  Pro Gln His 
    3050                 3055                 3060             


Val Ala  Val Ile Leu Asn Gln  Glu Ile Arg Glu Leu  Glu Arg Gln 
    3065                 3070                 3075             


Gln Glu  Gln Leu Val Lys Ile  Cys Lys Asn Cys Thr  Gly Cys Phe 
    3080                 3085                 3090             


Asp Arg  His Ile Pro Cys Val  Ser Leu Asn Cys Pro  Val Leu Phe 
    3095                 3100                 3105             


Lys Leu  Ser Arg Val Asn Arg  Glu Leu Ser Lys Ala  Pro Tyr Leu 
    3110                 3115                 3120             


Arg Gln  Leu Leu Asp Gln Phe  
    3125                 3130 


<210>  154
<211>  119
<212>  PRT
<213>  homo sapiens

<400>  154

Met Lys Ala Leu Ser Pro Val Arg Gly Cys Tyr Glu Ala Val Cys Cys 
1               5                   10                  15      


Leu Ser Glu Arg Ser Leu Ala Ile Ala Arg Gly Arg Gly Lys Gly Pro 
            20                  25                  30          


Ala Ala Glu Glu Pro Leu Ser Leu Leu Asp Asp Met Asn His Cys Tyr 
        35                  40                  45              


Ser Arg Leu Arg Glu Leu Val Pro Gly Val Pro Arg Gly Thr Gln Leu 
    50                  55                  60                  


Ser Gln Val Glu Ile Leu Gln Arg Val Ile Asp Tyr Ile Leu Asp Leu 
65                  70                  75                  80  


Gln Val Val Leu Ala Glu Pro Ala Pro Gly Pro Pro Asp Gly Pro His 
                85                  90                  95      


Leu Pro Ile Gln Thr Ala Glu Leu Ala Pro Glu Leu Val Ile Ser Asn 
            100                 105                 110         


Asp Lys Arg Ser Phe Cys His 
        115                 


<210>  155
<211>  631
<212>  PRT
<213>  homo sapiens

<400>  155

Met Ala Pro Pro Gly Ser Ser Thr Val Phe Leu Leu Ala Leu Thr Ile 
1               5                   10                  15      


Ile Ala Ser Thr Trp Ala Leu Thr Pro Thr His Tyr Leu Thr Lys His 
            20                  25                  30          


Asp Val Glu Arg Leu Lys Ala Ser Leu Asp Arg Pro Phe Thr Asn Leu 
        35                  40                  45              


Glu Ser Ala Phe Tyr Ser Ile Val Gly Leu Ser Ser Leu Gly Ala Gln 
    50                  55                  60                  


Val Pro Asp Ala Lys Lys Ala Cys Thr Tyr Ile Arg Ser Asn Leu Asp 
65                  70                  75                  80  


Pro Ser Asn Val Asp Ser Leu Phe Tyr Ala Ala Gln Ala Ser Gln Ala 
                85                  90                  95      


Leu Ser Gly Cys Glu Ile Ser Ile Ser Asn Glu Thr Lys Asp Leu Leu 
            100                 105                 110         


Leu Ala Ala Val Ser Glu Asp Ser Ser Val Thr Gln Ile Tyr His Ala 
        115                 120                 125             


Val Ala Ala Leu Ser Gly Phe Gly Leu Pro Leu Ala Ser Gln Glu Ala 
    130                 135                 140                 


Leu Ser Ala Leu Thr Ala Arg Leu Ser Lys Glu Glu Thr Val Leu Ala 
145                 150                 155                 160 


Thr Val Gln Ala Leu Gln Thr Ala Ser His Leu Ser Gln Gln Ala Asp 
                165                 170                 175     


Leu Arg Ser Ile Val Glu Glu Ile Glu Asp Leu Val Ala Arg Leu Asp 
            180                 185                 190         


Glu Leu Gly Gly Val Tyr Leu Gln Phe Glu Glu Gly Leu Glu Thr Thr 
        195                 200                 205             


Ala Leu Phe Val Ala Ala Thr Tyr Lys Leu Met Asp His Val Gly Thr 
    210                 215                 220                 


Glu Pro Ser Ile Lys Glu Asp Gln Val Ile Gln Leu Met Asn Ala Ile 
225                 230                 235                 240 


Phe Ser Lys Lys Asn Phe Glu Ser Leu Ser Glu Ala Phe Ser Val Ala 
                245                 250                 255     


Ser Ala Ala Ala Val Leu Ser His Asn Arg Tyr His Val Pro Val Val 
            260                 265                 270         


Val Val Pro Glu Gly Ser Ala Ser Asp Thr His Glu Gln Ala Ile Leu 
        275                 280                 285             


Arg Leu Gln Val Thr Asn Val Leu Ser Gln Pro Leu Thr Gln Ala Thr 
    290                 295                 300                 


Val Lys Leu Glu His Ala Lys Ser Val Ala Ser Arg Ala Thr Val Leu 
305                 310                 315                 320 


Gln Lys Thr Ser Phe Thr Pro Val Gly Asp Val Phe Glu Leu Asn Phe 
                325                 330                 335     


Met Asn Val Lys Phe Ser Ser Gly Tyr Tyr Asp Phe Leu Val Glu Val 
            340                 345                 350         


Glu Gly Asp Asn Arg Tyr Ile Ala Asn Thr Val Glu Leu Arg Val Lys 
        355                 360                 365             


Ile Ser Thr Glu Val Gly Ile Thr Asn Val Asp Leu Ser Thr Val Asp 
    370                 375                 380                 


Lys Asp Gln Ser Ile Ala Pro Lys Thr Thr Arg Val Thr Tyr Pro Ala 
385                 390                 395                 400 


Lys Ala Lys Gly Thr Phe Ile Ala Asp Ser His Gln Asn Phe Ala Leu 
                405                 410                 415     


Phe Phe Gln Leu Val Asp Val Asn Thr Gly Ala Glu Leu Thr Pro His 
            420                 425                 430         


Gln Thr Phe Val Arg Leu His Asn Gln Lys Thr Gly Gln Glu Val Val 
        435                 440                 445             


Phe Val Ala Glu Pro Asp Asn Lys Asn Val Tyr Lys Phe Glu Leu Asp 
    450                 455                 460                 


Thr Ser Glu Arg Lys Ile Glu Phe Asp Ser Ala Ser Gly Thr Tyr Thr 
465                 470                 475                 480 


Leu Tyr Leu Ile Ile Gly Asp Ala Thr Leu Lys Asn Pro Ile Leu Trp 
                485                 490                 495     


Asn Val Ala Asp Val Val Ile Lys Phe Pro Glu Glu Glu Ala Pro Ser 
            500                 505                 510         


Thr Val Leu Ser Gln Asn Leu Phe Thr Pro Lys Gln Glu Ile Gln His 
        515                 520                 525             


Leu Phe Arg Glu Pro Glu Lys Arg Pro Pro Thr Val Val Ser Asn Thr 
    530                 535                 540                 


Phe Thr Ala Leu Ile Leu Ser Pro Leu Leu Leu Leu Phe Ala Leu Trp 
545                 550                 555                 560 


Ile Arg Ile Gly Ala Asn Val Ser Asn Phe Thr Phe Ala Pro Ser Thr 
                565                 570                 575     


Ile Ile Phe His Leu Gly His Ala Ala Met Leu Gly Leu Met Tyr Val 
            580                 585                 590         


Tyr Trp Thr Gln Leu Asn Met Phe Gln Thr Leu Lys Tyr Leu Ala Ile 
        595                 600                 605             


Leu Gly Ser Val Thr Phe Leu Ala Gly Asn Arg Met Leu Ala Gln Gln 
    610                 615                 620                 


Ala Val Lys Arg Thr Ala His 
625                 630     


<210>  156
<211>  605
<212>  PRT
<213>  homo sapiens

<400>  156

Met Gly Arg Leu Leu Arg Ala Ala Arg Leu Pro Pro Leu Leu Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Val Gly Gly Ala Phe Leu Gly Ala Cys Val Ala 
            20                  25                  30          


Gly Ser Asp Glu Pro Gly Pro Glu Gly Leu Thr Ser Thr Ser Leu Leu 
        35                  40                  45              


Asp Leu Leu Leu Pro Thr Gly Leu Glu Pro Leu Asp Ser Glu Glu Pro 
    50                  55                  60                  


Ser Glu Thr Met Gly Leu Gly Ala Gly Leu Gly Ala Pro Gly Ser Gly 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Asn Glu Glu Ser Arg Ile Leu Gln Pro Pro Gln 
                85                  90                  95      


Tyr Phe Trp Glu Glu Glu Glu Glu Leu Asn Asp Ser Ser Leu Asp Leu 
            100                 105                 110         


Gly Pro Thr Ala Asp Tyr Val Phe Pro Asp Leu Thr Glu Lys Ala Gly 
        115                 120                 125             


Ser Ile Glu Asp Thr Ser Gln Ala Gln Glu Leu Pro Asn Leu Pro Ser 
    130                 135                 140                 


Pro Leu Pro Lys Met Asn Leu Val Glu Pro Pro Trp His Met Pro Pro 
145                 150                 155                 160 


Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Arg Glu Lys Glu 
                165                 170                 175     


Glu Val Glu Lys Gln Glu Glu Glu Glu Glu Glu Glu Leu Leu Pro Val 
            180                 185                 190         


Asn Gly Ser Gln Glu Glu Ala Lys Pro Gln Val Arg Asp Phe Ser Leu 
        195                 200                 205             


Thr Ser Ser Ser Gln Thr Pro Gly Ala Thr Lys Ser Arg His Glu Asp 
    210                 215                 220                 


Ser Gly Asp Gln Ala Ser Ser Gly Val Glu Val Glu Ser Ser Met Gly 
225                 230                 235                 240 


Pro Ser Leu Leu Leu Pro Ser Val Thr Pro Thr Thr Val Thr Pro Gly 
                245                 250                 255     


Asp Gln Asp Ser Thr Ser Gln Glu Ala Glu Ala Thr Val Leu Pro Ala 
            260                 265                 270         


Ala Gly Leu Gly Val Glu Phe Glu Ala Pro Gln Glu Ala Ser Glu Glu 
        275                 280                 285             


Ala Thr Ala Gly Ala Ala Gly Leu Ser Gly Gln His Glu Glu Val Pro 
    290                 295                 300                 


Ala Leu Pro Ser Phe Pro Gln Thr Thr Ala Pro Ser Gly Ala Glu His 
305                 310                 315                 320 


Pro Asp Glu Asp Pro Leu Gly Ser Arg Thr Ser Ala Ser Ser Pro Leu 
                325                 330                 335     


Ala Pro Gly Asp Met Glu Leu Thr Pro Ser Ser Ala Thr Leu Gly Gln 
            340                 345                 350         


Glu Asp Leu Asn Gln Gln Leu Leu Glu Gly Gln Ala Ala Glu Ala Gln 
        355                 360                 365             


Ser Arg Ile Pro Trp Asp Ser Thr Gln Val Ile Cys Lys Asp Trp Ser 
    370                 375                 380                 


Asn Leu Ala Gly Lys Asn Tyr Ile Ile Leu Asn Met Thr Glu Asn Ile 
385                 390                 395                 400 


Asp Cys Glu Val Phe Arg Gln His Arg Gly Pro Gln Leu Leu Ala Leu 
                405                 410                 415     


Val Glu Glu Val Leu Pro Arg His Gly Ser Gly His His Gly Ala Trp 
            420                 425                 430         


His Ile Ser Leu Ser Lys Pro Ser Glu Lys Glu Gln His Leu Leu Met 
        435                 440                 445             


Thr Leu Val Gly Glu Gln Gly Val Val Pro Thr Gln Asp Val Leu Ser 
    450                 455                 460                 


Met Leu Gly Asp Ile Arg Arg Ser Leu Glu Glu Ile Gly Ile Gln Asn 
465                 470                 475                 480 


Tyr Ser Thr Thr Ser Ser Cys Gln Ala Arg Ala Ser Gln Val Arg Ser 
                485                 490                 495     


Asp Tyr Gly Thr Leu Phe Val Val Leu Val Val Ile Gly Ala Ile Cys 
            500                 505                 510         


Ile Ile Ile Ile Ala Leu Gly Leu Leu Tyr Asn Cys Trp Gln Arg Arg 
        515                 520                 525             


Leu Pro Lys Leu Lys His Val Ser His Gly Glu Glu Leu Arg Phe Val 
    530                 535                 540                 


Glu Asn Gly Cys His Asp Asn Pro Thr Leu Asp Val Ala Ser Asp Ser 
545                 550                 555                 560 


Gln Ser Glu Met Gln Glu Lys His Pro Ser Leu Asn Gly Gly Gly Ala 
                565                 570                 575     


Leu Asn Gly Pro Gly Ser Trp Gly Ala Leu Met Gly Gly Lys Arg Asp 
            580                 585                 590         


Pro Glu Asp Ser Asp Val Phe Glu Glu Asp Thr His Leu 
        595                 600                 605 


<210>  157
<211>  340
<212>  PRT
<213>  homo sapiens

<400>  157

Met Gly Pro Pro His Ser Gly Pro Gly Gly Val Arg Val Gly Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Val Leu Gly Leu Val Ser Gly Leu Ser Leu Glu Pro 
            20                  25                  30          


Val Tyr Trp Asn Ser Ala Asn Lys Arg Phe Gln Ala Glu Gly Gly Tyr 
        35                  40                  45              


Val Leu Tyr Pro Gln Ile Gly Asp Arg Leu Asp Leu Leu Cys Pro Arg 
    50                  55                  60                  


Ala Arg Pro Pro Gly Pro His Ser Ser Pro Asn Tyr Glu Phe Tyr Lys 
65                  70                  75                  80  


Leu Tyr Leu Val Gly Gly Ala Gln Gly Arg Arg Cys Glu Ala Pro Pro 
                85                  90                  95      


Ala Pro Asn Leu Leu Leu Thr Cys Asp Arg Pro Asp Leu Asp Leu Arg 
            100                 105                 110         


Phe Thr Ile Lys Phe Gln Glu Tyr Ser Pro Asn Leu Trp Gly His Glu 
        115                 120                 125             


Phe Arg Ser His His Asp Tyr Tyr Ile Ile Ala Thr Ser Asp Gly Thr 
    130                 135                 140                 


Arg Glu Gly Leu Glu Ser Leu Gln Gly Gly Val Cys Leu Thr Arg Gly 
145                 150                 155                 160 


Met Lys Val Leu Leu Arg Val Gly Gln Ser Pro Arg Gly Gly Ala Val 
                165                 170                 175     


Pro Arg Lys Pro Val Ser Glu Met Pro Met Glu Arg Asp Arg Gly Ala 
            180                 185                 190         


Ala His Ser Leu Glu Pro Gly Lys Glu Asn Leu Pro Gly Asp Pro Thr 
        195                 200                 205             


Ser Asn Ala Thr Ser Arg Gly Ala Glu Gly Pro Leu Pro Pro Pro Ser 
    210                 215                 220                 


Met Pro Ala Val Ala Gly Ala Ala Gly Gly Leu Ala Leu Leu Leu Leu 
225                 230                 235                 240 


Gly Val Ala Gly Ala Gly Gly Ala Met Cys Trp Arg Arg Arg Arg Ala 
                245                 250                 255     


Lys Pro Ser Glu Ser Arg His Pro Gly Pro Gly Ser Phe Gly Arg Gly 
            260                 265                 270         


Gly Ser Leu Gly Leu Gly Gly Gly Gly Gly Met Gly Pro Arg Glu Ala 
        275                 280                 285             


Glu Pro Gly Glu Leu Gly Ile Ala Leu Arg Gly Gly Gly Ala Ala Asp 
    290                 295                 300                 


Pro Pro Phe Cys Pro His Tyr Glu Lys Val Ser Gly Asp Tyr Gly His 
305                 310                 315                 320 


Pro Val Tyr Ile Val Gln Asp Gly Pro Pro Gln Ser Pro Pro Asn Ile 
                325                 330                 335     


Tyr Tyr Lys Val 
            340 


<210>  158
<211>  864
<212>  PRT
<213>  homo sapiens

<400>  158

Met Ala Ala Pro Leu Ile Pro Leu Ser Gln Gln Ile Pro Thr Gly Asn 
1               5                   10                  15      


Ser Leu Tyr Glu Ser Tyr Tyr Lys Gln Val Asp Pro Ala Tyr Thr Gly 
            20                  25                  30          


Arg Val Gly Ala Ser Glu Ala Ala Leu Phe Leu Lys Lys Ser Gly Leu 
        35                  40                  45              


Ser Asp Ile Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Pro Glu Gly 
    50                  55                  60                  


Lys Gly Phe Leu Asp Lys Gln Gly Phe Tyr Val Ala Leu Arg Leu Val 
65                  70                  75                  80  


Ala Cys Ala Gln Ser Gly His Glu Val Thr Leu Ser Asn Leu Asn Leu 
                85                  90                  95      


Ser Met Pro Pro Pro Lys Phe His Asp Thr Ser Ser Pro Leu Met Val 
            100                 105                 110         


Thr Pro Pro Ser Ala Glu Ala His Trp Ala Val Arg Val Glu Glu Lys 
        115                 120                 125             


Ala Lys Phe Asp Gly Ile Phe Glu Ser Leu Leu Pro Ile Asn Gly Leu 
    130                 135                 140                 


Leu Ser Gly Asp Lys Val Lys Pro Val Leu Met Asn Ser Lys Leu Pro 
145                 150                 155                 160 


Leu Asp Val Leu Gly Arg Val Trp Asp Leu Ser Asp Ile Asp Lys Asp 
                165                 170                 175     


Gly His Leu Asp Arg Asp Glu Phe Ala Val Ala Met His Leu Val Tyr 
            180                 185                 190         


Arg Ala Leu Glu Lys Glu Pro Val Pro Ser Ala Leu Pro Pro Ser Leu 
        195                 200                 205             


Ile Pro Pro Ser Lys Arg Lys Lys Thr Val Phe Pro Gly Ala Val Pro 
    210                 215                 220                 


Val Leu Pro Ala Ser Pro Pro Pro Lys Asp Ser Leu Arg Ser Thr Pro 
225                 230                 235                 240 


Ser His Gly Ser Val Ser Ser Leu Asn Ser Thr Gly Ser Leu Ser Pro 
                245                 250                 255     


Lys His Ser Leu Lys Gln Thr Gln Pro Thr Val Asn Trp Val Val Pro 
            260                 265                 270         


Val Ala Asp Lys Met Arg Phe Asp Glu Ile Phe Leu Lys Thr Asp Leu 
        275                 280                 285             


Asp Leu Asp Gly Tyr Val Ser Gly Gln Glu Val Lys Glu Ile Phe Met 
    290                 295                 300                 


His Ser Gly Leu Thr Gln Asn Leu Leu Ala His Ile Trp Ala Leu Ala 
305                 310                 315                 320 


Asp Thr Arg Gln Thr Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala 
                325                 330                 335     


Met Tyr Phe Ile Gln Gln Lys Val Ser Lys Gly Ile Asp Pro Pro Gln 
            340                 345                 350         


Val Leu Ser Pro Asp Met Val Pro Pro Ser Glu Arg Gly Thr Pro Gly 
        355                 360                 365             


Pro Asp Ser Ser Gly Ser Leu Gly Ser Gly Glu Phe Thr Gly Val Lys 
    370                 375                 380                 


Glu Leu Asp Asp Ile Ser Gln Glu Ile Ala Gln Leu Gln Arg Glu Lys 
385                 390                 395                 400 


Tyr Ser Leu Glu Gln Asp Ile Arg Glu Lys Glu Glu Ala Ile Arg Gln 
                405                 410                 415     


Lys Thr Ser Glu Val Gln Glu Leu Gln Asn Asp Leu Asp Arg Glu Thr 
            420                 425                 430         


Ser Ser Leu Gln Glu Leu Glu Ala Gln Lys Gln Asp Ala Gln Asp Arg 
        435                 440                 445             


Leu Asp Glu Met Asp Gln Gln Lys Ala Lys Leu Arg Asp Met Leu Ser 
    450                 455                 460                 


Asp Val Arg Gln Lys Cys Gln Asp Glu Thr Gln Met Ile Ser Ser Leu 
465                 470                 475                 480 


Lys Thr Gln Ile Gln Ser Gln Glu Ser Asp Leu Lys Ser Gln Glu Asp 
                485                 490                 495     


Asp Leu Asn Arg Ala Lys Ser Glu Leu Asn Arg Leu Gln Gln Glu Glu 
            500                 505                 510         


Thr Gln Leu Glu Gln Ser Ile Gln Ala Gly Arg Val Gln Leu Glu Thr 
        515                 520                 525             


Ile Ile Lys Ser Leu Lys Ser Thr Gln Asp Glu Ile Asn Gln Ala Arg 
    530                 535                 540                 


Ser Lys Leu Ser Gln Leu His Glu Ser Arg Gln Glu Ala His Arg Ser 
545                 550                 555                 560 


Leu Glu Gln Tyr Asp Gln Val Leu Asp Gly Ala His Gly Ala Ser Leu 
                565                 570                 575     


Thr Asp Leu Ala Asn Leu Ser Glu Gly Val Ser Leu Ala Glu Arg Gly 
            580                 585                 590         


Ser Phe Gly Ala Met Asp Asp Pro Phe Lys Asn Lys Ala Leu Leu Phe 
        595                 600                 605             


Ser Asn Asn Thr Gln Glu Leu His Pro Asp Pro Phe Gln Thr Glu Asp 
    610                 615                 620                 


Pro Phe Lys Ser Asp Pro Phe Lys Gly Ala Asp Pro Phe Lys Gly Asp 
625                 630                 635                 640 


Pro Phe Gln Asn Asp Pro Phe Ala Glu Gln Gln Thr Thr Ser Thr Asp 
                645                 650                 655     


Pro Phe Gly Gly Asp Pro Phe Lys Glu Ser Asp Pro Phe Arg Gly Ser 
            660                 665                 670         


Ala Thr Asp Asp Phe Phe Lys Lys Gln Thr Lys Asn Asp Pro Phe Thr 
        675                 680                 685             


Ser Asp Pro Phe Thr Lys Asn Pro Ser Leu Pro Ser Lys Leu Asp Pro 
    690                 695                 700                 


Phe Glu Ser Ser Asp Pro Phe Ser Ser Ser Ser Val Ser Ser Lys Gly 
705                 710                 715                 720 


Ser Asp Pro Phe Gly Thr Leu Asp Pro Phe Gly Ser Gly Ser Phe Asn 
                725                 730                 735     


Ser Ala Glu Gly Phe Ala Asp Phe Ser Gln Met Ser Lys Pro Pro Pro 
            740                 745                 750         


Ser Gly Pro Phe Thr Ser Ser Leu Gly Gly Ala Gly Phe Ser Asp Asp 
        755                 760                 765             


Pro Phe Lys Ser Lys Gln Asp Thr Pro Ala Leu Pro Pro Lys Lys Pro 
    770                 775                 780                 


Ala Pro Pro Arg Pro Lys Pro Pro Ser Gly Lys Ser Thr Pro Val Ser 
785                 790                 795                 800 


Gln Leu Gly Ser Ala Asp Phe Pro Glu Ala Pro Asp Pro Phe Gln Pro 
                805                 810                 815     


Leu Gly Ala Asp Ser Gly Asp Pro Phe Gln Ser Lys Lys Gly Phe Gly 
            820                 825                 830         


Asp Pro Phe Ser Gly Lys Asp Pro Phe Val Pro Ser Ser Ala Ala Lys 
        835                 840                 845             


Pro Ser Lys Ala Ser Ala Ser Gly Phe Ala Asp Phe Thr Ser Val Ser 
    850                 855                 860                 


<210>  159
<211>  2549
<212>  PRT
<213>  homo sapiens

<400>  159

Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 
1               5                   10                  15      


Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
            20                  25                  30          


Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
        35                  40                  45              


Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
    50                  55                  60                  


Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
65                  70                  75                  80  


Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                85                  90                  95      


Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
            100                 105                 110         


Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 
        115                 120                 125             


Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
    130                 135                 140                 


Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
145                 150                 155                 160 


Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                165                 170                 175     


Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
            180                 185                 190         


Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
        195                 200                 205             


Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
    210                 215                 220                 


Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
225                 230                 235                 240 


Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                245                 250                 255     


Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
            260                 265                 270         


Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
        275                 280                 285             


Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
    290                 295                 300                 


Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
305                 310                 315                 320 


Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                325                 330                 335     


Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
            340                 345                 350         


Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
        355                 360                 365             


Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 
    370                 375                 380                 


Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
385                 390                 395                 400 


Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                405                 410                 415     


Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
            420                 425                 430         


Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
        435                 440                 445             


Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
    450                 455                 460                 


Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 
465                 470                 475                 480 


Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                485                 490                 495     


Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
            500                 505                 510         


Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
        515                 520                 525             


Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
    530                 535                 540                 


Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
545                 550                 555                 560 


Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                565                 570                 575     


Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
            580                 585                 590         


Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
        595                 600                 605             


His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
    610                 615                 620                 


Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
625                 630                 635                 640 


Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                645                 650                 655     


Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
            660                 665                 670         


Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
        675                 680                 685             


Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
    690                 695                 700                 


Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
705                 710                 715                 720 


Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                725                 730                 735     


Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
            740                 745                 750         


Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
        755                 760                 765             


Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
    770                 775                 780                 


Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
785                 790                 795                 800 


Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                805                 810                 815     


Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
            820                 825                 830         


Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
        835                 840                 845             


Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
    850                 855                 860                 


Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
865                 870                 875                 880 


Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                885                 890                 895     


Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
            900                 905                 910         


Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
        915                 920                 925             


Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
    930                 935                 940                 


Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
945                 950                 955                 960 


Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                965                 970                 975     


Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
            980                 985                 990         


Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 
        995                 1000                 1005             


Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 
    1010                 1015                 1020             


Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 
    1025                 1030                 1035             


Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 
    1040                 1045                 1050             


Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 
    1070                 1075                 1080             


His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 
    1100                 1105                 1110             


Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 
    1115                 1120                 1125             


Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 
    1130                 1135                 1140             


Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 
    1145                 1150                 1155             


Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 
    1160                 1165                 1170             


Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 
    1175                 1180                 1185             


Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 
    1190                 1195                 1200             


Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 
    1205                 1210                 1215             


Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 
    1220                 1225                 1230             


His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 
    1235                 1240                 1245             


Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 
    1250                 1255                 1260             


Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 
    1265                 1270                 1275             


Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 
    1280                 1285                 1290             


Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 
    1295                 1300                 1305             


Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 
    1310                 1315                 1320             


Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 
    1325                 1330                 1335             


Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 
    1340                 1345                 1350             


Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 
    1355                 1360                 1365             


Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 
    1370                 1375                 1380             


Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 
    1385                 1390                 1395             


Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 
    1400                 1405                 1410             


Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 
    1415                 1420                 1425             


Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 
    1430                 1435                 1440             


Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 
    1445                 1450                 1455             


Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 
    1460                 1465                 1470             


Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 
    1475                 1480                 1485             


Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 
    1490                 1495                 1500             


Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 
    1505                 1510                 1515             


Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 
    1520                 1525                 1530             


Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 
    1535                 1540                 1545             


Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 
    1550                 1555                 1560             


Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 
    1565                 1570                 1575             


Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 
    1580                 1585                 1590             


His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 
    1595                 1600                 1605             


Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 
    1610                 1615                 1620             


Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 
    1625                 1630                 1635             


Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 
    1640                 1645                 1650             


Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 
    1655                 1660                 1665             


Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 
    1670                 1675                 1680             


Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 
    1685                 1690                 1695             


Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 
    1700                 1705                 1710             


Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 
    1715                 1720                 1725             


Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 
    1730                 1735                 1740             


His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 
    1745                 1750                 1755             


Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 
    1760                 1765                 1770             


Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 
    1775                 1780                 1785             


Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 
    1790                 1795                 1800             


Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 
    1805                 1810                 1815             


His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 
    1820                 1825                 1830             


Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 
    1835                 1840                 1845             


Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 
    1850                 1855                 1860             


Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 
    1865                 1870                 1875             


Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 
    1880                 1885                 1890             


Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 
    1895                 1900                 1905             


Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 
    1910                 1915                 1920             


Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 
    1925                 1930                 1935             


Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 
    1940                 1945                 1950             


Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 
    1955                 1960                 1965             


Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 
    1985                 1990                 1995             


Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 
    2000                 2005                 2010             


Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 
    2015                 2020                 2025             


Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 
    2030                 2035                 2040             


Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 
    2045                 2050                 2055             


Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 
    2060                 2065                 2070             


Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 
    2075                 2080                 2085             


Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 
    2090                 2095                 2100             


Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 
    2105                 2110                 2115             


Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 
    2120                 2125                 2130             


Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 
    2135                 2140                 2145             


Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 
    2150                 2155                 2160             


Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 
    2165                 2170                 2175             


Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 
    2180                 2185                 2190             


Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 
    2195                 2200                 2205             


Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 
    2210                 2215                 2220             


Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 
    2225                 2230                 2235             


Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 
    2240                 2245                 2250             


Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 
    2255                 2260                 2265             


Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 
    2270                 2275                 2280             


Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 
    2285                 2290                 2295             


Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 
    2300                 2305                 2310             


Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 
    2315                 2320                 2325             


Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 
    2330                 2335                 2340             


Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 
    2345                 2350                 2355             


Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 
    2360                 2365                 2370             


Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 
    2375                 2380                 2385             


Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 
    2390                 2395                 2400             


Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 
    2405                 2410                 2415             


Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 
    2420                 2425                 2430             


Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 
    2435                 2440                 2445             


Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 
    2450                 2455                 2460             


Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 
    2465                 2470                 2475             


Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 
    2480                 2485                 2490             


Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 
    2495                 2500                 2505             


Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 
    2510                 2515                 2520             


Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 
    2525                 2530                 2535             


Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 
    2540                 2545                 


<210>  160
<211>  1269
<212>  PRT
<213>  homo sapiens

<400>  160

Met Glu Ala Thr Gly Val Leu Pro Phe Val Arg Gly Val Asp Leu Ser 
1               5                   10                  15      


Gly Asn Asp Phe Lys Gly Gly Tyr Phe Pro Glu Asn Val Lys Ala Met 
            20                  25                  30          


Thr Ser Leu Arg Trp Leu Lys Leu Asn Arg Thr Gly Leu Cys Tyr Leu 
        35                  40                  45              


Pro Glu Glu Leu Ala Ala Leu Gln Lys Leu Glu His Leu Ser Val Ser 
    50                  55                  60                  


His Asn Asn Leu Thr Thr Leu His Gly Glu Leu Ser Ser Leu Pro Ser 
65                  70                  75                  80  


Leu Arg Ala Ile Val Ala Arg Ala Asn Ser Leu Lys Asn Ser Gly Val 
                85                  90                  95      


Pro Asp Asp Ile Phe Lys Leu Asp Asp Leu Ser Val Leu Asp Leu Ser 
            100                 105                 110         


His Asn Gln Leu Thr Glu Cys Pro Arg Glu Leu Glu Asn Ala Lys Asn 
        115                 120                 125             


Met Leu Val Leu Asn Leu Ser His Asn Ser Ile Asp Thr Ile Pro Asn 
    130                 135                 140                 


Gln Leu Phe Ile Asn Leu Thr Asp Leu Leu Tyr Leu Asp Leu Ser Glu 
145                 150                 155                 160 


Asn Arg Leu Glu Ser Leu Pro Pro Gln Met Arg Arg Leu Val His Leu 
                165                 170                 175     


Gln Thr Leu Val Leu Asn Gly Asn Pro Leu Leu His Ala Gln Leu Arg 
            180                 185                 190         


Gln Leu Pro Ala Met Thr Ala Leu Gln Thr Leu His Leu Arg Ser Thr 
        195                 200                 205             


Gln Arg Thr Gln Ser Asn Leu Pro Thr Ser Leu Glu Gly Leu Ser Asn 
    210                 215                 220                 


Leu Ala Asp Val Asp Leu Ser Cys Asn Asp Leu Thr Arg Val Pro Glu 
225                 230                 235                 240 


Cys Leu Tyr Thr Leu Pro Ser Leu Arg Arg Leu Asn Leu Ser Ser Asn 
                245                 250                 255     


Gln Ile Thr Glu Leu Ser Leu Cys Ile Asp Gln Trp Val His Val Glu 
            260                 265                 270         


Thr Leu Asn Leu Ser Arg Asn Gln Leu Thr Ser Leu Pro Ser Ala Ile 
        275                 280                 285             


Cys Lys Leu Ser Lys Leu Lys Lys Leu Tyr Leu Asn Ser Asn Lys Leu 
    290                 295                 300                 


Asp Phe Asp Gly Leu Pro Ser Gly Ile Gly Lys Leu Thr Asn Leu Glu 
305                 310                 315                 320 


Glu Phe Met Ala Ala Asn Asn Asn Leu Glu Leu Val Pro Glu Ser Leu 
                325                 330                 335     


Cys Arg Cys Pro Lys Leu Arg Lys Leu Val Leu Asn Lys Asn His Leu 
            340                 345                 350         


Val Thr Leu Pro Glu Ala Ile His Phe Leu Thr Glu Ile Glu Val Leu 
        355                 360                 365             


Asp Val Arg Glu Asn Pro Asn Leu Val Met Pro Pro Lys Pro Ala Asp 
    370                 375                 380                 


Arg Ala Ala Glu Trp Tyr Asn Ile Asp Phe Ser Leu Gln Asn Gln Leu 
385                 390                 395                 400 


Arg Leu Ala Gly Ala Ser Pro Ala Thr Val Ala Ala Ala Ala Ala Ala 
                405                 410                 415     


Gly Ser Gly Pro Lys Asp Pro Met Ala Arg Lys Met Arg Leu Arg Arg 
            420                 425                 430         


Arg Lys Asp Ser Ala Gln Asp Asp Gln Ala Lys Gln Val Leu Lys Gly 
        435                 440                 445             


Met Ser Asp Val Ala Gln Glu Lys Asn Lys Lys Gln Glu Glu Ser Ala 
    450                 455                 460                 


Asp Ala Arg Ala Pro Ser Gly Lys Val Arg Arg Trp Asp Gln Gly Leu 
465                 470                 475                 480 


Glu Lys Pro Arg Leu Asp Tyr Ser Glu Phe Phe Thr Glu Asp Val Gly 
                485                 490                 495     


Gln Leu Pro Gly Leu Thr Ile Trp Gln Ile Glu Asn Phe Val Pro Val 
            500                 505                 510         


Leu Val Glu Glu Ala Phe His Gly Lys Phe Tyr Glu Ala Asp Cys Tyr 
        515                 520                 525             


Ile Val Leu Lys Thr Phe Leu Asp Asp Ser Gly Ser Leu Asn Trp Glu 
    530                 535                 540                 


Ile Tyr Tyr Trp Ile Gly Gly Glu Ala Thr Leu Asp Lys Lys Ala Cys 
545                 550                 555                 560 


Ser Ala Ile His Ala Val Asn Leu Arg Asn Tyr Leu Gly Ala Glu Cys 
                565                 570                 575     


Arg Thr Val Arg Glu Glu Met Gly Asp Glu Ser Glu Glu Phe Leu Gln 
            580                 585                 590         


Val Phe Asp Asn Asp Ile Ser Tyr Ile Glu Gly Gly Thr Ala Ser Gly 
        595                 600                 605             


Phe Tyr Thr Val Glu Asp Thr His Tyr Val Thr Arg Met Tyr Arg Val 
    610                 615                 620                 


Tyr Gly Lys Lys Asn Ile Lys Leu Glu Pro Val Pro Leu Lys Gly Thr 
625                 630                 635                 640 


Ser Leu Asp Pro Arg Phe Val Phe Leu Leu Asp Arg Gly Leu Asp Ile 
                645                 650                 655     


Tyr Val Trp Arg Gly Ala Gln Ala Thr Leu Ser Ser Thr Thr Lys Ala 
            660                 665                 670         


Arg Leu Phe Ala Glu Lys Ile Asn Lys Asn Glu Arg Lys Gly Lys Ala 
        675                 680                 685             


Glu Ile Thr Leu Leu Val Gln Gly Gln Glu Leu Pro Glu Phe Trp Glu 
    690                 695                 700                 


Ala Leu Gly Gly Glu Pro Ser Glu Ile Lys Lys His Val Pro Glu Asp 
705                 710                 715                 720 


Phe Trp Pro Pro Gln Pro Lys Leu Tyr Lys Val Gly Leu Gly Leu Gly 
                725                 730                 735     


Tyr Leu Glu Leu Pro Gln Ile Asn Tyr Lys Leu Ser Val Glu His Lys 
            740                 745                 750         


Gln Arg Pro Lys Val Glu Leu Met Pro Arg Met Arg Leu Leu Gln Ser 
        755                 760                 765             


Leu Leu Asp Thr Arg Cys Val Tyr Ile Leu Asp Cys Trp Ser Asp Val 
    770                 775                 780                 


Phe Ile Trp Leu Gly Arg Lys Ser Pro Arg Leu Val Arg Ala Ala Ala 
785                 790                 795                 800 


Leu Lys Leu Gly Gln Glu Leu Cys Gly Met Leu His Arg Pro Arg His 
                805                 810                 815     


Ala Thr Val Ser Arg Ser Leu Glu Gly Thr Glu Ala Gln Val Phe Lys 
            820                 825                 830         


Ala Lys Phe Lys Asn Trp Asp Asp Val Leu Thr Val Asp Tyr Thr Arg 
        835                 840                 845             


Asn Ala Glu Ala Val Leu Gln Ser Pro Gly Leu Ser Gly Lys Val Lys 
    850                 855                 860                 


Arg Asp Ala Glu Lys Lys Asp Gln Met Lys Ala Asp Leu Thr Ala Leu 
865                 870                 875                 880 


Phe Leu Pro Arg Gln Pro Pro Met Ser Leu Ala Glu Ala Glu Gln Leu 
                885                 890                 895     


Met Glu Glu Trp Asn Glu Asp Leu Asp Gly Met Glu Gly Phe Val Leu 
            900                 905                 910         


Glu Gly Lys Lys Phe Ala Arg Leu Pro Glu Glu Glu Phe Gly His Phe 
        915                 920                 925             


Tyr Thr Gln Asp Cys Tyr Val Phe Leu Cys Arg Tyr Trp Val Pro Val 
    930                 935                 940                 


Glu Tyr Glu Glu Glu Glu Lys Lys Glu Asp Lys Glu Glu Lys Ala Glu 
945                 950                 955                 960 


Gly Lys Glu Gly Glu Glu Ala Thr Ala Glu Ala Glu Glu Lys Gln Pro 
                965                 970                 975     


Glu Glu Asp Phe Gln Cys Ile Val Tyr Phe Trp Gln Gly Arg Glu Ala 
            980                 985                 990         


Ser Asn Met Gly Trp Leu Thr Phe  Thr Phe Ser Leu Gln  Lys Lys Phe 
        995                 1000                 1005             


Glu Ser  Leu Phe Pro Gly Lys  Leu Glu Val Val Arg  Met Thr Gln 
    1010                 1015                 1020             


Gln Gln  Glu Asn Pro Lys Phe  Leu Ser His Phe Lys  Arg Lys Phe 
    1025                 1030                 1035             


Ile Ile  His Arg Gly Lys Arg  Lys Ala Val Gln Gly  Ala Gln Gln 
    1040                 1045                 1050             


Pro Ser  Leu Tyr Gln Ile Arg  Thr Asn Gly Ser Ala  Leu Cys Thr 
    1055                 1060                 1065             


Arg Cys  Ile Gln Ile Asn Thr  Asp Ser Ser Leu Leu  Asn Ser Glu 
    1070                 1075                 1080             


Phe Cys  Phe Ile Leu Lys Val  Pro Phe Glu Ser Glu  Asp Asn Gln 
    1085                 1090                 1095             


Gly Ile  Val Tyr Ala Trp Val  Gly Arg Ala Ser Asp  Pro Asp Glu 
    1100                 1105                 1110             


Ala Lys  Leu Ala Glu Asp Ile  Leu Asn Thr Met Phe  Asp Thr Ser 
    1115                 1120                 1125             


Tyr Ser  Lys Gln Val Ile Asn  Glu Gly Glu Glu Pro  Glu Asn Phe 
    1130                 1135                 1140             


Phe Trp  Val Gly Ile Gly Ala  Gln Lys Pro Tyr Asp  Asp Asp Ala 
    1145                 1150                 1155             


Glu Tyr  Met Lys His Thr Arg  Leu Phe Arg Cys Ser  Asn Glu Lys 
    1160                 1165                 1170             


Gly Tyr  Phe Ala Val Thr Glu  Lys Cys Ser Asp Phe  Cys Gln Asp 
    1175                 1180                 1185             


Asp Leu  Ala Asp Asp Asp Ile  Met Leu Leu Asp Asn  Gly Gln Glu 
    1190                 1195                 1200             


Val Tyr  Met Trp Val Gly Thr  Gln Thr Ser Gln Val  Glu Ile Lys 
    1205                 1210                 1215             


Leu Ser  Leu Lys Ala Cys Gln  Val Tyr Ile Gln His  Met Arg Ser 
    1220                 1225                 1230             


Lys Glu  His Glu Arg Pro Arg  Arg Leu Arg Leu Val  Arg Lys Gly 
    1235                 1240                 1245             


Asn Glu  Gln His Ala Phe Thr  Arg Cys Phe His Ala  Trp Ser Ala 
    1250                 1255                 1260             


Phe Cys  Lys Ala Leu Ala 
    1265                 


<210>  161
<211>  512
<212>  PRT
<213>  homo sapiens

<400>  161

Met Ala Glu Ser Gly Leu Ala Met Trp Pro Ser Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Pro Gly Pro Pro Pro Val Ala Gly Leu Glu Asp Ala Ala Phe 
            20                  25                  30          


Pro His Leu Gly Glu Ser Leu Gln Pro Leu Leu Arg Ala Cys Pro Leu 
        35                  40                  45              


Arg Cys Ser Cys Pro Arg Val Asp Thr Val Asp Cys Asp Gly Leu Asp 
    50                  55                  60                  


Leu Arg Val Phe Pro Asp Asn Ile Thr Arg Ala Ala Gln His Leu Ser 
65                  70                  75                  80  


Leu Gln Asn Asn Gln Leu Gln Glu Leu Pro Tyr Asn Glu Leu Ser Arg 
                85                  90                  95      


Leu Ser Gly Leu Arg Thr Leu Asn Leu His Asn Asn Leu Ile Ser Ser 
            100                 105                 110         


Glu Gly Leu Pro Asp Glu Ala Phe Glu Ser Leu Thr Gln Leu Gln His 
        115                 120                 125             


Leu Cys Val Ala His Asn Lys Leu Ser Val Ala Pro Gln Phe Leu Pro 
    130                 135                 140                 


Arg Ser Leu Arg Val Ala Asp Leu Ala Ala Asn Gln Val Met Glu Ile 
145                 150                 155                 160 


Phe Pro Leu Thr Phe Gly Glu Lys Pro Ala Leu Arg Ser Val Tyr Leu 
                165                 170                 175     


His Asn Asn Gln Leu Ser Asn Ala Gly Leu Pro Pro Asp Ala Phe Arg 
            180                 185                 190         


Gly Ser Glu Ala Ile Ala Thr Leu Ser Leu Ser Asn Asn Gln Leu Ser 
        195                 200                 205             


Tyr Leu Pro Pro Ser Leu Pro Pro Ser Leu Glu Arg Leu His Leu Gln 
    210                 215                 220                 


Asn Asn Leu Ile Ser Lys Val Pro Arg Gly Ala Leu Ser Arg Gln Thr 
225                 230                 235                 240 


Gln Leu Arg Glu Leu Tyr Leu Gln His Asn Gln Leu Thr Asp Ser Gly 
                245                 250                 255     


Leu Asp Ala Thr Thr Phe Ser Lys Leu His Ser Leu Glu Tyr Leu Asp 
            260                 265                 270         


Leu Ser His Asn Gln Leu Thr Thr Val Pro Ala Gly Leu Pro Arg Thr 
        275                 280                 285             


Leu Ala Ile Leu His Leu Gly Arg Asn Arg Ile Arg Gln Val Glu Ala 
    290                 295                 300                 


Ala Arg Leu His Gly Ala Arg Gly Leu Arg Tyr Leu Leu Leu Gln His 
305                 310                 315                 320 


Asn Gln Leu Gly Ser Ser Gly Leu Pro Ala Gly Ala Leu Arg Pro Leu 
                325                 330                 335     


Arg Gly Leu His Thr Leu His Leu Tyr Gly Asn Gly Leu Asp Arg Val 
            340                 345                 350         


Pro Pro Ala Leu Pro Arg Arg Leu Arg Ala Leu Val Leu Pro His Asn 
        355                 360                 365             


His Val Ala Ala Leu Gly Ala Arg Asp Leu Val Ala Thr Pro Gly Leu 
    370                 375                 380                 


Thr Glu Leu Asn Leu Ala Tyr Asn Arg Leu Ala Ser Ala Arg Val His 
385                 390                 395                 400 


His Arg Ala Phe Arg Arg Leu Arg Ala Leu Arg Ser Leu Asp Leu Ala 
                405                 410                 415     


Gly Asn Gln Leu Thr Arg Leu Pro Met Gly Leu Pro Thr Gly Leu Arg 
            420                 425                 430         


Thr Leu Gln Leu Gln Arg Asn Gln Leu Arg Met Leu Glu Pro Glu Pro 
        435                 440                 445             


Leu Ala Gly Leu Asp Gln Leu Arg Glu Leu Ser Leu Ala His Asn Arg 
    450                 455                 460                 


Leu Arg Val Gly Asp Ile Gly Pro Gly Thr Trp His Glu Leu Gln Ala 
465                 470                 475                 480 


Leu Gln Val Arg His Arg Leu Val Ser His Thr Val Pro Arg Ala Pro 
                485                 490                 495     


Pro Ser Pro Cys Leu Pro Cys His Val Pro Asn Ile Leu Val Ser Trp 
            500                 505                 510         


<210>  162
<211>  398
<212>  PRT
<213>  homo sapiens

<400>  162

Met Ala Leu Leu Arg Arg Pro Thr Val Ser Ser Asp Leu Glu Asn Ile 
1               5                   10                  15      


Asp Thr Gly Val Asn Ser Lys Val Lys Ser His Val Thr Ile Arg Arg 
            20                  25                  30          


Thr Val Leu Glu Glu Ile Gly Asn Arg Val Thr Thr Arg Ala Ala Gln 
        35                  40                  45              


Val Ala Lys Lys Ala Gln Asn Thr Lys Val Pro Val Gln Pro Thr Lys 
    50                  55                  60                  


Thr Thr Asn Val Asn Lys Gln Leu Lys Pro Thr Ala Ser Val Lys Pro 
65                  70                  75                  80  


Val Gln Met Glu Lys Leu Ala Pro Lys Gly Pro Ser Pro Thr Pro Glu 
                85                  90                  95      


Asp Val Ser Met Lys Glu Glu Asn Leu Cys Gln Ala Phe Ser Asp Ala 
            100                 105                 110         


Leu Leu Cys Lys Ile Glu Asp Ile Asp Asn Glu Asp Trp Glu Asn Pro 
        115                 120                 125             


Gln Leu Cys Ser Asp Tyr Val Lys Asp Ile Tyr Gln Tyr Leu Arg Gln 
    130                 135                 140                 


Leu Glu Val Leu Gln Ser Ile Asn Pro His Phe Leu Asp Gly Arg Asp 
145                 150                 155                 160 


Ile Asn Gly Arg Met Arg Ala Ile Leu Val Asp Trp Leu Val Gln Val 
                165                 170                 175     


His Ser Lys Phe Arg Leu Leu Gln Glu Thr Leu Tyr Met Cys Val Gly 
            180                 185                 190         


Ile Met Asp Arg Phe Leu Gln Val Gln Pro Val Ser Arg Lys Lys Leu 
        195                 200                 205             


Gln Leu Val Gly Ile Thr Ala Leu Leu Leu Ala Ser Lys Tyr Glu Glu 
    210                 215                 220                 


Met Phe Ser Pro Asn Ile Glu Asp Phe Val Tyr Ile Thr Asp Asn Ala 
225                 230                 235                 240 


Tyr Thr Ser Ser Gln Ile Arg Glu Met Glu Thr Leu Ile Leu Lys Glu 
                245                 250                 255     


Leu Lys Phe Glu Leu Gly Arg Pro Leu Pro Leu His Phe Leu Arg Arg 
            260                 265                 270         


Ala Ser Lys Ala Gly Glu Val Asp Val Glu Gln His Thr Leu Ala Lys 
        275                 280                 285             


Tyr Leu Met Glu Leu Thr Leu Ile Asp Tyr Asp Met Val His Tyr His 
    290                 295                 300                 


Pro Ser Lys Val Ala Ala Ala Ala Ser Cys Leu Ser Gln Lys Val Leu 
305                 310                 315                 320 


Gly Gln Gly Lys Trp Asn Leu Lys Gln Gln Tyr Tyr Thr Gly Tyr Thr 
                325                 330                 335     


Glu Asn Glu Val Leu Glu Val Met Gln His Met Ala Lys Asn Val Val 
            340                 345                 350         


Lys Val Asn Glu Asn Leu Thr Lys Phe Ile Ala Ile Lys Asn Lys Tyr 
        355                 360                 365             


Ala Ser Ser Lys Leu Leu Lys Ile Ser Met Ile Pro Gln Leu Asn Ser 
    370                 375                 380                 


Lys Ala Val Lys Asp Leu Ala Ser Pro Leu Ile Gly Arg Ser 
385                 390                 395             


<210>  163
<211>  374
<212>  PRT
<213>  homo sapiens

<400>  163

Met Ser Val Pro Ala Phe Ile Asp Ile Ser Glu Glu Asp Gln Ala Ala 
1               5                   10                  15      


Glu Leu Arg Ala Tyr Leu Lys Ser Lys Gly Ala Glu Ile Ser Glu Glu 
            20                  25                  30          


Asn Ser Glu Gly Gly Leu His Val Asp Leu Ala Gln Ile Ile Glu Ala 
        35                  40                  45              


Cys Asp Val Cys Leu Lys Glu Asp Asp Lys Asp Val Glu Ser Val Val 
    50                  55                  60                  


Asn Ser Val Val Ser Leu Leu Leu Ile Leu Glu Pro Asp Lys Gln Glu 
65                  70                  75                  80  


Ala Leu Ile Glu Ser Leu Cys Glu Lys Leu Val Lys Phe Arg Glu Gly 
                85                  90                  95      


Glu Arg Pro Ser Leu Arg Leu Gln Leu Leu Ser Asn Leu Phe His Gly 
            100                 105                 110         


Met Asp Lys Asn Thr Pro Val Arg Tyr Thr Val Tyr Cys Ser Leu Ile 
        115                 120                 125             


Glu Val Val Ala Ser Cys Gly Ala Ile Gln Tyr Ile Pro Thr Glu Leu 
    130                 135                 140                 


Asp Gln Val Arg Lys Trp Ile Ser Asp Trp Asn Leu Thr Thr Glu Lys 
145                 150                 155                 160 


Lys His Thr Leu Leu Arg Leu Leu Tyr Glu Ala Leu Ala Asp Cys Lys 
                165                 170                 175     


Lys Ser Asp Ala Ala Ser Lys Val Met Val Glu Leu Leu Gly Ser Tyr 
            180                 185                 190         


Thr Glu Asp Asn Ala Ser Gln Ala Arg Val Asp Ala His Arg Cys Ile 
        195                 200                 205             


Val Glu Pro Leu Lys Asp Pro Asn Ala Phe Leu Phe Asp His Leu Leu 
    210                 215                 220                 


Thr Leu Lys Pro Val Lys Phe Leu Glu Gly Glu Leu Ile His Asp Leu 
225                 230                 235                 240 


Leu Thr Ile Phe Val Ser Ala Lys Leu Ala Ser Tyr Val Lys Phe Tyr 
                245                 250                 255     


Gln Asn Asn Lys Asp Phe Ile Asp Ser Leu Gly Leu Leu His Glu Gln 
            260                 265                 270         


Asn Met Ala Lys Met Arg Leu Leu Thr Phe Met Gly Met Ala Ile Glu 
        275                 280                 285             


Asn Lys Glu Ile Ser Phe Asp Thr Met Gln Gln Glu Leu Gln Ile Gly 
    290                 295                 300                 


Ala Asp Asp Val Glu Ala Phe Val Ile Asp Ala Val Arg Thr Lys Met 
305                 310                 315                 320 


Val Tyr Cys Lys Ile Asp Gln Thr Gln Arg Lys Val Val Val Ser His 
                325                 330                 335     


Ser Thr His Arg Thr Phe Gly Lys Gln Arg Trp Gln Gln Leu Tyr Asp 
            340                 345                 350         


Thr Leu Asn Ala Trp Lys Gln Asn Leu Asn Lys Val Lys Asn Ser Leu 
        355                 360                 365             


Leu Ser Leu Ser Asp Thr 
    370                 


<210>  164
<211>  434
<212>  PRT
<213>  homo sapiens

<400>  164

Met Ser Ile Glu Lys Ile Trp Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Ala Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gln Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Asp His Ile Asn Ser Thr Ile Ala Pro Ala Leu Ile Ser Ser 
65                  70                  75                  80  


Gly Leu Ser Val Val Glu Gln Glu Lys Leu Asp Asn Leu Met Leu Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Arg Glu Leu 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Gln Leu Ala Gly Asn Ser Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Glu 
                165                 170                 175     


Ser Phe Arg Asp Ala Met Arg Leu Gly Ala Glu Val Tyr His Thr Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Asp Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Ser Glu Ala Leu 
    210                 215                 220                 


Glu Leu Val Lys Glu Ala Ile Asp Lys Ala Gly Tyr Thr Glu Lys Ile 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asp Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Thr Asp Pro Ser Arg Tyr Ile Thr 
            260                 265                 270         


Gly Asp Gln Leu Gly Ala Leu Tyr Gln Asp Phe Val Arg Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Ala Trp 
    290                 295                 300                 


Ser Lys Phe Thr Ala Asn Val Gly Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Glu Arg Ala Val Glu Glu Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ala Ile Gln Ala Cys Lys Leu Ala Gln Glu Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Asp Glu Ala Arg Phe Ala Gly His Asn Phe Arg Asn Pro Ser 
            420                 425                 430         


Val Leu 
        


<210>  165
<211>  1314
<212>  PRT
<213>  homo sapiens

<400>  165

Met Ala Leu Arg Pro Gly Ala Gly Ser Gly Gly Gly Gly Ala Ala Gly 
1               5                   10                  15      


Ala Gly Ala Gly Ser Ala Gly Gly Gly Gly Phe Met Phe Pro Val Ala 
            20                  25                  30          


Gly Gly Ile Arg Pro Pro Gln Ala Gly Leu Met Pro Met Gln Gln Gln 
        35                  40                  45              


Gly Phe Pro Met Val Ser Val Met Gln Pro Asn Met Gln Gly Ile Met 
    50                  55                  60                  


Gly Met Asn Tyr Ser Ser Gln Met Ser Gln Gly Pro Ile Ala Met Gln 
65                  70                  75                  80  


Ala Gly Ile Pro Met Gly Pro Met Pro Ala Ala Gly Met Pro Tyr Leu 
                85                  90                  95      


Gly Gln Ala Pro Phe Leu Gly Met Arg Pro Pro Gly Pro Gln Tyr Thr 
            100                 105                 110         


Pro Asp Met Gln Lys Gln Phe Ala Glu Glu Gln Gln Lys Arg Phe Glu 
        115                 120                 125             


Gln Gln Gln Lys Leu Leu Glu Glu Glu Arg Lys Arg Arg Gln Phe Glu 
    130                 135                 140                 


Glu Gln Lys Gln Lys Leu Arg Leu Leu Ser Ser Val Lys Pro Lys Thr 
145                 150                 155                 160 


Gly Glu Lys Ser Arg Asp Asp Ala Leu Glu Ala Ile Lys Gly Asn Leu 
                165                 170                 175     


Asp Gly Phe Ser Arg Asp Ala Lys Met His Pro Thr Pro Ala Ser His 
            180                 185                 190         


Pro Lys Lys Pro Gly Pro Ser Leu Glu Glu Lys Phe Leu Val Ser Cys 
        195                 200                 205             


Asp Ile Ser Thr Ser Gly Gln Glu Gln Ile Lys Leu Asn Thr Ser Glu 
    210                 215                 220                 


Val Gly His Lys Ala Leu Gly Pro Gly Ser Ser Lys Lys Tyr Pro Ser 
225                 230                 235                 240 


Leu Met Ala Ser Asn Gly Val Ala Val Asp Gly Cys Val Ser Gly Thr 
                245                 250                 255     


Thr Thr Ala Glu Ala Glu Asn Thr Ser Asp Gln Asn Leu Ser Ile Glu 
            260                 265                 270         


Glu Ser Gly Val Gly Val Phe Pro Ser Gln Asp Pro Ala Gln Pro Arg 
        275                 280                 285             


Met Pro Pro Trp Ile Tyr Asn Glu Ser Leu Val Pro Asp Ala Tyr Lys 
    290                 295                 300                 


Lys Ile Leu Glu Thr Thr Met Thr Pro Thr Gly Ile Asp Thr Ala Lys 
305                 310                 315                 320 


Leu Tyr Pro Ile Leu Met Ser Ser Gly Leu Pro Arg Glu Thr Leu Gly 
                325                 330                 335     


Gln Ile Trp Ala Leu Ala Asn Arg Thr Thr Pro Gly Lys Leu Thr Lys 
            340                 345                 350         


Glu Glu Leu Tyr Thr Val Leu Ala Met Ile Ala Val Thr Gln Arg Gly 
        355                 360                 365             


Val Pro Ala Met Ser Pro Asp Ala Leu Asn Gln Phe Pro Ala Ala Pro 
    370                 375                 380                 


Ile Pro Thr Leu Ser Gly Phe Ser Met Thr Leu Pro Thr Pro Val Ser 
385                 390                 395                 400 


Gln Pro Thr Val Ile Pro Ser Gly Pro Ala Gly Ser Met Pro Leu Ser 
                405                 410                 415     


Leu Gly Gln Pro Val Met Gly Ile Asn Leu Val Gly Pro Val Gly Gly 
            420                 425                 430         


Ala Ala Ala Gln Ala Ser Ser Gly Phe Ile Pro Thr Tyr Pro Ala Asn 
        435                 440                 445             


Gln Val Val Lys Pro Glu Glu Asp Asp Phe Gln Asp Phe Gln Asp Ala 
    450                 455                 460                 


Ser Lys Ser Gly Ser Leu Asp Asp Ser Phe Ser Asp Phe Gln Glu Leu 
465                 470                 475                 480 


Pro Ala Ser Ser Lys Thr Ser Asn Ser Gln His Gly Asn Ser Ala Pro 
                485                 490                 495     


Ser Leu Leu Met Pro Leu Pro Gly Thr Lys Ala Leu Pro Ser Met Asp 
            500                 505                 510         


Lys Tyr Ala Val Phe Lys Gly Ile Ala Ala Asp Lys Ser Ser Glu Asn 
        515                 520                 525             


Thr Val Pro Pro Gly Asp Pro Gly Asp Lys Tyr Ser Ala Phe Arg Glu 
    530                 535                 540                 


Leu Glu Gln Thr Ala Glu Asn Lys Pro Leu Gly Glu Ser Phe Ala Glu 
545                 550                 555                 560 


Phe Arg Ser Ala Gly Thr Asp Asp Gly Phe Thr Asp Phe Lys Thr Ala 
                565                 570                 575     


Asp Ser Val Ser Pro Leu Glu Pro Pro Thr Lys Asp Lys Thr Phe Pro 
            580                 585                 590         


Pro Ser Phe Pro Ser Gly Thr Ile Gln Gln Lys Gln Gln Thr Gln Val 
        595                 600                 605             


Lys Asn Pro Leu Asn Leu Ala Asp Leu Asp Met Phe Ser Ser Val Asn 
    610                 615                 620                 


Cys Ser Ser Glu Lys Pro Leu Ser Phe Ser Ala Val Phe Ser Thr Ser 
625                 630                 635                 640 


Lys Ser Val Ser Thr Pro Gln Ser Thr Gly Ser Ala Ala Thr Met Thr 
                645                 650                 655     


Ala Leu Ala Ala Thr Lys Thr Ser Ser Leu Ala Asp Asp Phe Gly Glu 
            660                 665                 670         


Phe Ser Leu Phe Gly Glu Tyr Ser Gly Leu Ala Pro Val Gly Glu Gln 
        675                 680                 685             


Asp Asp Phe Ala Asp Phe Met Ala Phe Ser Asn Ser Ser Ile Ser Ser 
    690                 695                 700                 


Glu Gln Lys Pro Asp Asp Lys Tyr Asp Ala Leu Lys Glu Glu Ala Ser 
705                 710                 715                 720 


Pro Val Pro Leu Thr Ser Asn Val Gly Ser Thr Val Lys Gly Gly Gln 
                725                 730                 735     


Asn Ser Thr Ala Ala Ser Thr Lys Tyr Asp Val Phe Arg Gln Leu Ser 
            740                 745                 750         


Leu Glu Gly Ser Gly Leu Gly Val Glu Asp Leu Lys Asp Asn Thr Pro 
        755                 760                 765             


Ser Gly Lys Ser Asp Asp Asp Phe Ala Asp Phe His Ser Ser Lys Phe 
    770                 775                 780                 


Ser Ser Ile Asn Ser Asp Lys Ser Leu Gly Glu Lys Ala Val Ala Phe 
785                 790                 795                 800 


Arg His Thr Lys Glu Asp Ser Ala Ser Val Lys Ser Leu Asp Leu Pro 
                805                 810                 815     


Ser Ile Gly Gly Ser Ser Val Gly Lys Glu Asp Ser Glu Asp Ala Leu 
            820                 825                 830         


Ser Val Gln Phe Asp Met Lys Leu Ala Asp Val Gly Gly Asp Leu Lys 
        835                 840                 845             


His Val Met Ser Asp Ser Ser Leu Asp Leu Pro Thr Val Ser Gly Gln 
    850                 855                 860                 


His Pro Pro Ala Ala Asp Ile Glu Asp Leu Lys Tyr Ala Ala Phe Gly 
865                 870                 875                 880 


Ser Tyr Ser Ser Asn Phe Ala Val Ser Thr Leu Thr Ser Tyr Asp Trp 
                885                 890                 895     


Ser Asp Arg Asp Asp Ala Thr Gln Gly Arg Lys Leu Ser Pro Phe Val 
            900                 905                 910         


Leu Ser Ala Gly Ser Gly Ser Pro Ser Ala Thr Ser Ile Leu Gln Lys 
        915                 920                 925             


Lys Glu Thr Ser Phe Gly Ser Ser Glu Asn Ile Thr Met Thr Ser Leu 
    930                 935                 940                 


Ser Lys Val Thr Thr Phe Val Ser Glu Asp Ala Leu Pro Glu Thr Thr 
945                 950                 955                 960 


Phe Pro Ala Leu Ala Ser Phe Lys Asp Thr Ile Pro Gln Thr Ser Glu 
                965                 970                 975     


Gln Lys Glu Tyr Glu Asn Arg Asp Tyr Lys Asp Phe Thr Lys Gln Asp 
            980                 985                 990         


Leu Pro Thr Ala Glu Arg Ser Gln  Glu Ala Thr Cys Pro  Ser Pro Ala 
        995                 1000                 1005             


Ser Ser  Gly Ala Ser Gln Glu  Thr Pro Asn Glu Cys  Ser Asp Asp 
    1010                 1015                 1020             


Phe Gly  Glu Phe Gln Ser Glu  Lys Pro Lys Ile Ser  Lys Phe Asp 
    1025                 1030                 1035             


Phe Leu  Val Ala Thr Ser Gln  Ser Lys Met Lys Ser  Ser Glu Glu 
    1040                 1045                 1050             


Met Ile  Lys Ser Glu Leu Ala  Thr Phe Asp Leu Ser  Val Gln Gly 
    1055                 1060                 1065             


Ser His  Lys Arg Ser Leu Ser  Leu Gly Asp Lys Glu  Ile Ser Arg 
    1070                 1075                 1080             


Ser Ser  Pro Ser Pro Ala Leu  Glu Gln Pro Phe Arg  Asp Arg Ser 
    1085                 1090                 1095             


Asn Thr  Leu Asn Glu Lys Pro  Ala Leu Pro Val Ile  Arg Asp Lys 
    1100                 1105                 1110             


Tyr Lys  Asp Leu Thr Gly Glu  Val Glu Glu Asn Glu  Arg Tyr Ala 
    1115                 1120                 1125             


Tyr Glu  Trp Gln Arg Cys Leu  Gly Ser Ala Leu Asn  Val Ile Lys 
    1130                 1135                 1140             


Lys Ala  Asn Asp Thr Leu Asn  Gly Ile Ser Ser Ser  Ser Val Cys 
    1145                 1150                 1155             


Thr Glu  Val Ile Gln Ser Ala  Gln Gly Met Glu Tyr  Leu Leu Gly 
    1160                 1165                 1170             


Val Val  Glu Val Tyr Arg Val  Thr Lys Arg Val Glu  Leu Gly Ile 
    1175                 1180                 1185             


Lys Ala  Thr Ala Val Cys Ser  Glu Lys Leu Gln Gln  Leu Leu Lys 
    1190                 1195                 1200             


Asp Ile  Asp Lys Val Trp Asn  Asn Leu Ile Gly Phe  Met Ser Leu 
    1205                 1210                 1215             


Ala Thr  Leu Thr Pro Asp Glu  Asn Ser Leu Asp Phe  Ser Ser Cys 
    1220                 1225                 1230             


Met Leu  Arg Pro Gly Ile Lys  Asn Ala Gln Glu Leu  Ala Cys Gly 
    1235                 1240                 1245             


Val Cys  Leu Leu Asn Val Asp  Ser Arg Ser Arg Lys  Glu Glu Lys 
    1250                 1255                 1260             


Pro Ala  Glu Glu His Pro Lys  Lys Ala Phe Asn Ser  Glu Thr Asp 
    1265                 1270                 1275             


Ser Phe  Lys Leu Ala Tyr Gly  Gly His Gln Tyr His  Ala Ser Cys 
    1280                 1285                 1290             


Ala Asn  Phe Trp Ile Asn Cys  Val Glu Pro Lys Pro  Pro Gly Leu 
    1295                 1300                 1305             


Val Leu  Pro Asp Leu Leu 
    1310                 


<210>  166
<211>  214
<212>  PRT
<213>  homo sapiens

<400>  166

Met Arg Thr Leu Leu Leu Val Leu Trp Leu Ala Thr Arg Gly Ser Ala 
1               5                   10                  15      


Leu Tyr Phe His Ile Gly Glu Thr Glu Lys Lys Cys Phe Ile Glu Glu 
            20                  25                  30          


Ile Pro Asp Glu Thr Met Val Ile Gly Asn Tyr Arg Thr Gln Leu Tyr 
        35                  40                  45              


Asp Lys Gln Arg Glu Glu Tyr Gln Pro Ala Thr Pro Gly Leu Gly Met 
    50                  55                  60                  


Phe Val Glu Val Lys Asp Pro Glu Asp Lys Val Ile Leu Ala Arg Gln 
65                  70                  75                  80  


Tyr Gly Ser Glu Gly Arg Phe Thr Phe Thr Ser His Thr Pro Gly Glu 
                85                  90                  95      


His Gln Ile Cys Leu His Ser Asn Ser Thr Lys Phe Ser Leu Phe Ala 
            100                 105                 110         


Gly Gly Met Leu Arg Val His Leu Asp Ile Gln Val Gly Glu His Ala 
        115                 120                 125             


Asn Asp Tyr Ala Glu Ile Ala Ala Lys Asp Lys Leu Ser Glu Leu Gln 
    130                 135                 140                 


Leu Arg Val Arg Gln Leu Val Glu Gln Val Glu Gln Ile Gln Lys Glu 
145                 150                 155                 160 


Gln Asn Tyr Gln Arg Trp Arg Glu Glu Arg Phe Arg Gln Thr Ser Glu 
                165                 170                 175     


Ser Thr Asn Gln Arg Val Leu Trp Trp Ser Ile Leu Gln Thr Leu Ile 
            180                 185                 190         


Leu Val Ala Ile Gly Val Trp Gln Met Arg His Leu Lys Ser Phe Phe 
        195                 200                 205             


Glu Ala Lys Lys Leu Val 
    210                 


<210>  167
<211>  3259
<212>  PRT
<213>  homo sapiens

<400>  167

Met Leu Ser Arg Leu Ser Gly Leu Ala Asn Val Val Leu His Glu Leu 
1               5                   10                  15      


Ser Gly Asp Asp Asp Thr Asp Gln Asn Met Arg Ala Pro Leu Asp Pro 
            20                  25                  30          


Glu Leu His Gln Glu Ser Asp Met Glu Phe Asn Asn Thr Thr Gln Glu 
        35                  40                  45              


Asp Val Gln Glu Arg Leu Ala Tyr Ala Glu Gln Leu Val Val Glu Leu 
    50                  55                  60                  


Lys Asp Ile Ile Arg Gln Lys Asp Val Gln Leu Gln Gln Lys Asp Glu 
65                  70                  75                  80  


Ala Leu Gln Glu Glu Arg Lys Ala Ala Asp Asn Lys Ile Lys Lys Leu 
                85                  90                  95      


Lys Leu His Ala Lys Ala Lys Leu Thr Ser Leu Asn Lys Tyr Ile Glu 
            100                 105                 110         


Glu Met Lys Ala Gln Gly Gly Thr Val Leu Pro Thr Glu Pro Gln Ser 
        115                 120                 125             


Glu Glu Gln Leu Ser Lys His Asp Lys Ser Ser Thr Glu Glu Glu Met 
    130                 135                 140                 


Glu Ile Glu Lys Ile Lys His Lys Leu Gln Glu Lys Glu Glu Leu Ile 
145                 150                 155                 160 


Ser Thr Leu Gln Ala Gln Leu Thr Gln Ala Gln Ala Glu Gln Pro Ala 
                165                 170                 175     


Gln Ser Ser Thr Glu Met Glu Glu Phe Val Met Met Lys Gln Gln Leu 
            180                 185                 190         


Gln Glu Lys Glu Glu Phe Ile Ser Thr Leu Gln Ala Gln Leu Ser Gln 
        195                 200                 205             


Thr Gln Ala Glu Gln Ala Ala Gln Gln Val Val Arg Glu Lys Asp Ala 
    210                 215                 220                 


Arg Phe Glu Thr Gln Val Arg Leu His Glu Asp Glu Leu Leu Gln Leu 
225                 230                 235                 240 


Val Thr Gln Ala Asp Val Glu Thr Glu Met Gln Gln Lys Leu Arg Val 
                245                 250                 255     


Leu Gln Arg Lys Leu Glu Glu His Glu Glu Ser Leu Val Gly Arg Ala 
            260                 265                 270         


Gln Val Val Asp Leu Leu Gln Gln Glu Leu Thr Ala Ala Glu Gln Arg 
        275                 280                 285             


Asn Gln Ile Leu Ser Gln Gln Leu Gln Gln Met Glu Ala Glu His Asn 
    290                 295                 300                 


Thr Leu Arg Asn Thr Val Glu Thr Glu Arg Glu Glu Ser Lys Ile Leu 
305                 310                 315                 320 


Leu Glu Lys Met Glu Leu Glu Val Ala Glu Arg Lys Leu Ser Phe His 
                325                 330                 335     


Asn Leu Gln Glu Glu Met His His Leu Leu Glu Gln Phe Glu Gln Ala 
            340                 345                 350         


Gly Gln Ala Gln Ala Glu Leu Glu Ser Arg Tyr Ser Ala Leu Glu Gln 
        355                 360                 365             


Lys His Lys Ala Glu Met Glu Glu Lys Thr Ser His Ile Leu Ser Leu 
    370                 375                 380                 


Gln Lys Thr Gly Gln Glu Leu Gln Ser Ala Cys Asp Ala Leu Lys Asp 
385                 390                 395                 400 


Gln Asn Ser Lys Leu Leu Gln Asp Lys Asn Glu Gln Ala Val Gln Ser 
                405                 410                 415     


Ala Gln Thr Ile Gln Gln Leu Glu Asp Gln Leu Gln Gln Lys Ser Lys 
            420                 425                 430         


Glu Ile Ser Gln Phe Leu Asn Arg Leu Pro Leu Gln Gln His Glu Thr 
        435                 440                 445             


Ala Ser Gln Thr Ser Phe Pro Asp Val Tyr Asn Glu Gly Thr Gln Ala 
    450                 455                 460                 


Val Thr Glu Glu Asn Ile Ala Ser Leu Gln Lys Arg Val Val Glu Leu 
465                 470                 475                 480 


Glu Asn Glu Lys Gly Ala Leu Leu Leu Ser Ser Ile Glu Leu Glu Glu 
                485                 490                 495     


Leu Lys Ala Glu Asn Glu Lys Leu Ser Ser Gln Ile Thr Leu Leu Glu 
            500                 505                 510         


Ala Gln Asn Arg Thr Gly Glu Ala Asp Arg Glu Val Ser Glu Ile Ser 
        515                 520                 525             


Ile Val Asp Ile Ala Asn Lys Arg Ser Ser Ser Ala Glu Glu Ser Gly 
    530                 535                 540                 


Gln Asp Val Leu Glu Asn Thr Phe Ser Gln Lys His Lys Glu Leu Ser 
545                 550                 555                 560 


Val Leu Leu Leu Glu Met Lys Glu Ala Gln Glu Glu Ile Ala Phe Leu 
                565                 570                 575     


Lys Leu Gln Leu Gln Gly Lys Arg Ala Glu Glu Ala Asp His Glu Val 
            580                 585                 590         


Leu Asp Gln Lys Glu Met Lys Gln Met Glu Gly Glu Gly Ile Ala Pro 
        595                 600                 605             


Ile Lys Met Lys Val Phe Leu Glu Asp Thr Gly Gln Asp Phe Pro Leu 
    610                 615                 620                 


Met Pro Asn Glu Glu Ser Ser Leu Pro Ala Val Glu Lys Glu Gln Ala 
625                 630                 635                 640 


Ser Thr Glu His Gln Ser Arg Thr Ser Glu Glu Ile Ser Leu Asn Asp 
                645                 650                 655     


Ala Gly Val Glu Leu Lys Ser Thr Lys Gln Asp Gly Asp Lys Ser Leu 
            660                 665                 670         


Ser Ala Val Pro Asp Ile Gly Gln Cys His Gln Asp Glu Leu Glu Arg 
        675                 680                 685             


Leu Lys Ser Gln Ile Leu Glu Leu Glu Leu Asn Phe His Lys Ala Gln 
    690                 695                 700                 


Glu Ile Tyr Glu Lys Asn Leu Asp Glu Lys Ala Lys Glu Ile Ser Asn 
705                 710                 715                 720 


Leu Asn Gln Leu Ile Glu Glu Phe Lys Lys Asn Ala Asp Asn Asn Ser 
                725                 730                 735     


Ser Ala Phe Thr Ala Leu Ser Glu Glu Arg Asp Gln Leu Leu Ser Gln 
            740                 745                 750         


Val Lys Glu Leu Ser Met Val Thr Glu Leu Arg Ala Gln Val Lys Gln 
        755                 760                 765             


Leu Glu Met Asn Leu Ala Glu Ala Glu Arg Gln Arg Arg Leu Asp Tyr 
    770                 775                 780                 


Glu Ser Gln Thr Ala His Asp Asn Leu Leu Thr Glu Gln Ile His Ser 
785                 790                 795                 800 


Leu Ser Ile Glu Ala Lys Ser Lys Asp Val Lys Ile Glu Val Leu Gln 
                805                 810                 815     


Asn Glu Leu Asp Asp Val Gln Leu Gln Phe Ser Glu Gln Ser Thr Leu 
            820                 825                 830         


Ile Arg Ser Leu Gln Ser Gln Leu Gln Asn Lys Glu Ser Glu Val Leu 
        835                 840                 845             


Glu Gly Ala Glu Arg Val Arg His Ile Ser Ser Lys Val Glu Glu Leu 
    850                 855                 860                 


Ser Gln Ala Leu Ser Gln Lys Glu Leu Glu Ile Thr Lys Met Asp Gln 
865                 870                 875                 880 


Leu Leu Leu Glu Lys Lys Arg Asp Val Glu Thr Leu Gln Gln Thr Ile 
                885                 890                 895     


Glu Glu Lys Asp Gln Gln Val Thr Glu Ile Ser Phe Ser Met Thr Glu 
            900                 905                 910         


Lys Met Val Gln Leu Asn Glu Glu Lys Phe Ser Leu Gly Val Glu Ile 
        915                 920                 925             


Lys Thr Leu Lys Glu Gln Leu Asn Leu Leu Ser Arg Ala Glu Glu Ala 
    930                 935                 940                 


Lys Lys Glu Gln Val Glu Glu Asp Asn Glu Val Ser Ser Gly Leu Lys 
945                 950                 955                 960 


Gln Asn Tyr Asp Glu Met Ser Pro Ala Gly Gln Ile Ser Lys Glu Glu 
                965                 970                 975     


Leu Gln His Glu Phe Asp Leu Leu Lys Lys Glu Asn Glu Gln Arg Lys 
            980                 985                 990         


Arg Lys Leu Gln Ala Ala Leu Ile  Asn Arg Lys Glu Leu  Leu Gln Arg 
        995                 1000                 1005             


Val Ser  Arg Leu Glu Glu Glu  Leu Ala Asn Leu Lys  Asp Glu Ser 
    1010                 1015                 1020             


Lys Lys  Glu Ile Pro Leu Ser  Glu Thr Glu Arg Gly  Glu Val Glu 
    1025                 1030                 1035             


Glu Asp  Lys Glu Asn Lys Glu  Tyr Ser Glu Lys Cys  Val Thr Ser 
    1040                 1045                 1050             


Lys Cys  Gln Glu Ile Glu Ile  Tyr Leu Lys Gln Thr  Ile Ser Glu 
    1055                 1060                 1065             


Lys Glu  Val Glu Leu Gln His  Ile Arg Lys Asp Leu  Glu Glu Lys 
    1070                 1075                 1080             


Leu Ala  Ala Glu Glu Gln Phe  Gln Ala Leu Val Lys  Gln Met Asn 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asp Lys Thr  Asn Gln Ile Asp Leu  Leu Gln Ala 
    1100                 1105                 1110             


Glu Ile  Ser Glu Asn Gln Ala  Ile Ile Gln Lys Leu  Ile Thr Ser 
    1115                 1120                 1125             


Asn Thr  Asp Ala Ser Asp Gly  Asp Ser Val Ala Leu  Val Lys Glu 
    1130                 1135                 1140             


Thr Val  Val Ile Ser Pro Pro  Cys Thr Gly Ser Ser  Glu His Trp 
    1145                 1150                 1155             


Lys Pro  Glu Leu Glu Glu Lys  Ile Leu Ala Leu Glu  Lys Glu Lys 
    1160                 1165                 1170             


Glu Gln  Leu Gln Lys Lys Leu  Gln Glu Ala Leu Thr  Ser Arg Lys 
    1175                 1180                 1185             


Ala Ile  Leu Lys Lys Ala Gln  Glu Lys Glu Arg His  Leu Arg Glu 
    1190                 1195                 1200             


Glu Leu  Lys Gln Gln Lys Asp  Asp Tyr Asn Arg Leu  Gln Glu Gln 
    1205                 1210                 1215             


Phe Asp  Glu Gln Ser Lys Glu  Asn Glu Asn Ile Gly  Asp Gln Leu 
    1220                 1225                 1230             


Arg Gln  Leu Gln Ile Gln Val  Arg Glu Ser Ile Asp  Gly Lys Leu 
    1235                 1240                 1245             


Pro Ser  Thr Asp Gln Gln Glu  Ser Cys Ser Ser Thr  Pro Gly Leu 
    1250                 1255                 1260             


Glu Glu  Pro Leu Phe Lys Ala  Thr Glu Gln His His  Thr Gln Pro 
    1265                 1270                 1275             


Val Leu  Glu Ser Asn Leu Cys  Pro Asp Trp Pro Ser  His Ser Glu 
    1280                 1285                 1290             


Asp Ala  Ser Ala Leu Gln Gly  Gly Thr Ser Val Ala  Gln Ile Lys 
    1295                 1300                 1305             


Ala Gln  Leu Lys Glu Ile Glu  Ala Glu Lys Val Glu  Leu Glu Leu 
    1310                 1315                 1320             


Lys Val  Ser Ser Thr Thr Ser  Glu Leu Thr Lys Lys  Ser Glu Glu 
    1325                 1330                 1335             


Val Phe  Gln Leu Gln Glu Gln  Ile Asn Lys Gln Gly  Leu Glu Ile 
    1340                 1345                 1350             


Glu Ser  Leu Lys Thr Val Ser  His Glu Ala Glu Val  His Ala Glu 
    1355                 1360                 1365             


Ser Leu  Gln Gln Lys Leu Glu  Ser Ser Gln Leu Gln  Ile Ala Gly 
    1370                 1375                 1380             


Leu Glu  His Leu Arg Glu Leu  Gln Pro Lys Leu Asp  Glu Leu Gln 
    1385                 1390                 1395             


Lys Leu  Ile Ser Lys Lys Glu  Glu Asp Val Ser Tyr  Leu Ser Gly 
    1400                 1405                 1410             


Gln Leu  Ser Glu Lys Glu Ala  Ala Leu Thr Lys Ile  Gln Thr Glu 
    1415                 1420                 1425             


Ile Ile  Glu Gln Glu Asp Leu  Ile Lys Ala Leu His  Thr Gln Leu 
    1430                 1435                 1440             


Glu Met  Gln Ala Lys Glu His  Asp Glu Arg Ile Lys  Gln Leu Gln 
    1445                 1450                 1455             


Val Glu  Leu Cys Glu Met Lys  Gln Lys Pro Glu Glu  Ile Gly Glu 
    1460                 1465                 1470             


Glu Ser  Arg Ala Lys Gln Gln  Ile Gln Arg Lys Leu  Gln Ala Ala 
    1475                 1480                 1485             


Leu Ile  Ser Arg Lys Glu Ala  Leu Lys Glu Asn Lys  Ser Leu Gln 
    1490                 1495                 1500             


Glu Glu  Leu Ser Leu Ala Arg  Gly Thr Ile Glu Arg  Leu Thr Lys 
    1505                 1510                 1515             


Ser Leu  Ala Asp Val Glu Ser  Gln Val Ser Ala Gln  Asn Lys Glu 
    1520                 1525                 1530             


Lys Asp  Thr Val Leu Gly Arg  Leu Ala Leu Leu Gln  Glu Glu Arg 
    1535                 1540                 1545             


Asp Lys  Leu Ile Thr Glu Met  Asp Arg Ser Leu Leu  Glu Asn Gln 
    1550                 1555                 1560             


Ser Leu  Ser Ser Ser Cys Glu  Ser Leu Lys Leu Ala  Leu Glu Gly 
    1565                 1570                 1575             


Leu Thr  Glu Asp Lys Glu Lys  Leu Val Lys Glu Ile  Glu Ser Leu 
    1580                 1585                 1590             


Lys Ser  Ser Lys Ile Ala Glu  Ser Thr Glu Trp Gln  Glu Lys His 
    1595                 1600                 1605             


Lys Glu  Leu Gln Lys Glu Tyr  Glu Ile Leu Leu Gln  Ser Tyr Glu 
    1610                 1615                 1620             


Asn Val  Ser Asn Glu Ala Glu  Arg Ile Gln His Val  Val Glu Ala 
    1625                 1630                 1635             


Val Arg  Gln Glu Lys Gln Glu  Leu Tyr Gly Lys Leu  Arg Ser Thr 
    1640                 1645                 1650             


Glu Ala  Asn Lys Lys Glu Thr  Glu Lys Gln Leu Gln  Glu Ala Glu 
    1655                 1660                 1665             


Gln Glu  Met Glu Glu Met Lys  Glu Lys Met Arg Lys  Phe Ala Lys 
    1670                 1675                 1680             


Ser Lys  Gln Gln Lys Ile Leu  Glu Leu Glu Glu Glu  Asn Asp Arg 
    1685                 1690                 1695             


Leu Arg  Ala Glu Val His Pro  Ala Gly Asp Thr Ala  Lys Glu Cys 
    1700                 1705                 1710             


Met Glu  Thr Leu Leu Ser Ser  Asn Ala Ser Met Lys  Glu Glu Leu 
    1715                 1720                 1725             


Glu Arg  Val Lys Met Glu Tyr  Glu Thr Leu Ser Lys  Lys Phe Gln 
    1730                 1735                 1740             


Ser Leu  Met Ser Glu Lys Asp  Ser Leu Ser Glu Glu  Val Gln Asp 
    1745                 1750                 1755             


Leu Lys  His Gln Ile Glu Gly  Asn Val Ser Lys Gln  Ala Asn Leu 
    1760                 1765                 1770             


Glu Ala  Thr Glu Lys His Asp  Asn Gln Thr Asn Val  Thr Glu Glu 
    1775                 1780                 1785             


Gly Thr  Gln Ser Ile Pro Gly  Glu Thr Glu Glu Gln  Asp Ser Leu 
    1790                 1795                 1800             


Ser Met  Ser Thr Arg Pro Thr  Cys Ser Glu Ser Val  Pro Ser Ala 
    1805                 1810                 1815             


Lys Ser  Ala Asn Pro Ala Val  Ser Lys Asp Phe Ser  Ser His Asp 
    1820                 1825                 1830             


Glu Ile  Asn Asn Tyr Leu Gln  Gln Ile Asp Gln Leu  Lys Glu Arg 
    1835                 1840                 1845             


Ile Ala  Gly Leu Glu Glu Glu  Lys Gln Lys Asn Lys  Glu Phe Ser 
    1850                 1855                 1860             


Gln Thr  Leu Glu Asn Glu Lys  Asn Thr Leu Leu Ser  Gln Ile Ser 
    1865                 1870                 1875             


Thr Lys  Asp Gly Glu Leu Lys  Met Leu Gln Glu Glu  Val Thr Lys 
    1880                 1885                 1890             


Met Asn  Leu Leu Asn Gln Gln  Ile Gln Glu Glu Leu  Ser Arg Val 
    1895                 1900                 1905             


Thr Lys  Leu Lys Glu Thr Ala  Glu Glu Glu Lys Asp  Asp Leu Glu 
    1910                 1915                 1920             


Glu Arg  Leu Met Asn Gln Leu  Ala Glu Leu Asn Gly  Ser Ile Gly 
    1925                 1930                 1935             


Asn Tyr  Cys Gln Asp Val Thr  Asp Ala Gln Ile Lys  Asn Glu Leu 
    1940                 1945                 1950             


Leu Glu  Ser Glu Met Lys Asn  Leu Lys Lys Cys Val  Ser Glu Leu 
    1955                 1960                 1965             


Glu Glu  Glu Lys Gln Gln Leu  Val Lys Glu Lys Thr  Lys Val Glu 
    1970                 1975                 1980             


Ser Glu  Ile Arg Lys Glu Tyr  Leu Glu Lys Ile Gln  Gly Ala Gln 
    1985                 1990                 1995             


Lys Glu  Pro Gly Asn Lys Ser  His Ala Lys Glu Leu  Gln Glu Leu 
    2000                 2005                 2010             


Leu Lys  Glu Lys Gln Gln Glu  Val Lys Gln Leu Gln  Lys Asp Cys 
    2015                 2020                 2025             


Ile Arg  Tyr Gln Glu Lys Ile  Ser Ala Leu Glu Arg  Thr Val Lys 
    2030                 2035                 2040             


Ala Leu  Glu Phe Val Gln Thr  Glu Ser Gln Lys Asp  Leu Glu Ile 
    2045                 2050                 2055             


Thr Lys  Glu Asn Leu Ala Gln  Ala Val Glu His Arg  Lys Lys Ala 
    2060                 2065                 2070             


Gln Ala  Glu Leu Ala Ser Phe  Lys Val Leu Leu Asp  Asp Thr Gln 
    2075                 2080                 2085             


Ser Glu  Ala Ala Arg Val Leu  Ala Asp Asn Leu Lys  Leu Lys Lys 
    2090                 2095                 2100             


Glu Leu  Gln Ser Asn Lys Glu  Ser Val Lys Ser Gln  Met Lys Gln 
    2105                 2110                 2115             


Lys Asp  Glu Asp Leu Glu Arg  Arg Leu Glu Gln Ala  Glu Glu Lys 
    2120                 2125                 2130             


His Leu  Lys Glu Lys Lys Asn  Met Gln Glu Lys Leu  Asp Ala Leu 
    2135                 2140                 2145             


Arg Arg  Glu Lys Val His Leu  Glu Glu Thr Ile Gly  Glu Ile Gln 
    2150                 2155                 2160             


Val Thr  Leu Asn Lys Lys Asp  Lys Glu Val Gln Gln  Leu Gln Glu 
    2165                 2170                 2175             


Asn Leu  Asp Ser Thr Val Thr  Gln Leu Ala Ala Phe  Thr Lys Ser 
    2180                 2185                 2190             


Met Ser  Ser Leu Gln Asp Asp  Arg Asp Arg Val Ile  Asp Glu Ala 
    2195                 2200                 2205             


Lys Lys  Trp Glu Arg Lys Phe  Ser Asp Ala Ile Gln  Ser Lys Glu 
    2210                 2215                 2220             


Glu Glu  Ile Arg Leu Lys Glu  Asp Asn Cys Ser Val  Leu Lys Asp 
    2225                 2230                 2235             


Gln Leu  Arg Gln Met Ser Ile  His Met Glu Glu Leu  Lys Ile Asn 
    2240                 2245                 2250             


Ile Ser  Arg Leu Glu His Asp  Lys Gln Ile Trp Glu  Ser Lys Ala 
    2255                 2260                 2265             


Gln Thr  Glu Val Gln Leu Gln  Gln Lys Val Cys Asp  Thr Leu Gln 
    2270                 2275                 2280             


Gly Glu  Asn Lys Glu Leu Leu  Ser Gln Leu Glu Glu  Thr Arg His 
    2285                 2290                 2295             


Leu Tyr  His Ser Ser Gln Asn  Glu Leu Ala Lys Leu  Glu Ser Glu 
    2300                 2305                 2310             


Leu Lys  Ser Leu Lys Asp Gln  Leu Thr Asp Leu Ser  Asn Ser Leu 
    2315                 2320                 2325             


Glu Lys  Cys Lys Glu Gln Lys  Gly Asn Leu Glu Gly  Ile Ile Arg 
    2330                 2335                 2340             


Gln Gln  Glu Ala Asp Ile Gln  Asn Ser Lys Phe Ser  Tyr Glu Gln 
    2345                 2350                 2355             


Leu Glu  Thr Asp Leu Gln Ala  Ser Arg Glu Leu Thr  Ser Arg Leu 
    2360                 2365                 2370             


His Glu  Glu Ile Asn Met Lys  Glu Gln Lys Ile Ile  Ser Leu Leu 
    2375                 2380                 2385             


Ser Gly  Lys Glu Glu Ala Ile  Gln Val Ala Ile Ala  Glu Leu Arg 
    2390                 2395                 2400             


Gln Gln  His Asp Lys Glu Ile  Lys Glu Leu Glu Asn  Leu Leu Ser 
    2405                 2410                 2415             


Gln Glu  Glu Glu Glu Asn Ile  Val Leu Glu Glu Glu  Asn Lys Lys 
    2420                 2425                 2430             


Ala Val  Asp Lys Thr Asn Gln  Leu Met Glu Thr Leu  Lys Thr Ile 
    2435                 2440                 2445             


Lys Lys  Glu Asn Ile Gln Gln  Lys Ala Gln Leu Asp  Ser Phe Val 
    2450                 2455                 2460             


Lys Ser  Met Ser Ser Leu Gln  Asn Asp Arg Asp Arg  Ile Val Gly 
    2465                 2470                 2475             


Asp Tyr  Gln Gln Leu Glu Glu  Arg His Leu Ser Ile  Ile Leu Glu 
    2480                 2485                 2490             


Lys Asp  Gln Leu Ile Gln Glu  Ala Ala Ala Glu Asn  Asn Lys Leu 
    2495                 2500                 2505             


Lys Glu  Glu Ile Arg Gly Leu  Arg Ser His Met Asp  Asp Leu Asn 
    2510                 2515                 2520             


Ser Glu  Asn Ala Lys Leu Asp  Ala Glu Leu Ile Gln  Tyr Arg Glu 
    2525                 2530                 2535             


Asp Leu  Asn Gln Val Ile Thr  Ile Lys Asp Ser Gln  Gln Lys Gln 
    2540                 2545                 2550             


Leu Leu  Glu Val Gln Leu Gln  Gln Asn Lys Glu Leu  Glu Asn Lys 
    2555                 2560                 2565             


Tyr Ala  Lys Leu Glu Glu Lys  Leu Lys Glu Ser Glu  Glu Ala Asn 
    2570                 2575                 2580             


Glu Asp  Leu Arg Arg Ser Phe  Asn Ala Leu Gln Glu  Glu Lys Gln 
    2585                 2590                 2595             


Asp Leu  Ser Lys Glu Ile Glu  Ser Leu Lys Val Ser  Ile Ser Gln 
    2600                 2605                 2610             


Leu Thr  Arg Gln Val Thr Ala  Leu Gln Glu Glu Gly  Thr Leu Gly 
    2615                 2620                 2625             


Leu Tyr  His Ala Gln Leu Lys  Val Lys Glu Glu Glu  Val His Arg 
    2630                 2635                 2640             


Leu Ser  Ala Leu Phe Ser Ser  Ser Gln Lys Arg Ile  Ala Glu Leu 
    2645                 2650                 2655             


Glu Glu  Glu Leu Val Cys Val  Gln Lys Glu Ala Ala  Lys Lys Val 
    2660                 2665                 2670             


Gly Glu  Ile Glu Asp Lys Leu  Lys Lys Glu Leu Lys  His Leu His 
    2675                 2680                 2685             


His Asp  Ala Gly Ile Met Arg  Asn Glu Thr Glu Thr  Ala Glu Glu 
    2690                 2695                 2700             


Arg Val  Ala Glu Leu Ala Arg  Asp Leu Val Glu Met  Glu Gln Lys 
    2705                 2710                 2715             


Leu Leu  Met Val Thr Lys Glu  Asn Lys Gly Leu Thr  Ala Gln Ile 
    2720                 2725                 2730             


Gln Ser  Phe Gly Arg Ser Met  Ser Ser Leu Gln Asn  Ser Arg Asp 
    2735                 2740                 2745             


His Ala  Asn Glu Glu Leu Asp  Glu Leu Lys Arg Lys  Tyr Asp Ala 
    2750                 2755                 2760             


Ser Leu  Lys Glu Leu Ala Gln  Leu Lys Glu Gln Gly  Leu Leu Asn 
    2765                 2770                 2775             


Arg Glu  Arg Asp Ala Leu Leu  Ser Glu Thr Ala Phe  Ser Met Asn 
    2780                 2785                 2790             


Ser Thr  Glu Glu Asn Ser Leu  Ser His Leu Glu Lys  Leu Asn Gln 
    2795                 2800                 2805             


Gln Leu  Leu Ser Lys Asp Glu  Gln Leu Leu His Leu  Ser Ser Gln 
    2810                 2815                 2820             


Leu Glu  Asp Ser Tyr Asn Gln  Val Gln Ser Phe Ser  Lys Ala Met 
    2825                 2830                 2835             


Ala Ser  Leu Gln Asn Glu Arg  Asp His Leu Trp Asn  Glu Leu Glu 
    2840                 2845                 2850             


Lys Phe  Arg Lys Ser Glu Glu  Gly Lys Gln Arg Ser  Ala Ala Gln 
    2855                 2860                 2865             


Pro Ser  Thr Ser Pro Ala Glu  Val Gln Ser Leu Lys  Lys Ala Met 
    2870                 2875                 2880             


Ser Ser  Leu Gln Asn Asp Arg  Asp Arg Leu Leu Lys  Glu Leu Lys 
    2885                 2890                 2895             


Asn Leu  Gln Gln Gln Tyr Leu  Gln Ile Asn Gln Glu  Ile Thr Glu 
    2900                 2905                 2910             


Leu His  Pro Leu Lys Ala Gln  Leu Gln Glu Tyr Gln  Asp Lys Thr 
    2915                 2920                 2925             


Lys Ala  Phe Gln Ile Met Gln  Glu Glu Leu Arg Gln  Glu Asn Leu 
    2930                 2935                 2940             


Ser Trp  Gln His Glu Leu His  Gln Leu Arg Met Glu  Lys Ser Ser 
    2945                 2950                 2955             


Trp Glu  Ile His Glu Arg Arg  Met Lys Glu Gln Tyr  Leu Met Ala 
    2960                 2965                 2970             


Ile Ser  Asp Lys Asp Gln Gln  Leu Ser His Leu Gln  Asn Leu Ile 
    2975                 2980                 2985             


Arg Glu  Leu Arg Ser Ser Ser  Ser Gln Thr Gln Pro  Leu Lys Val 
    2990                 2995                 3000             


Gln Tyr  Gln Arg Gln Ala Ser  Pro Glu Thr Ser Ala  Ser Pro Asp 
    3005                 3010                 3015             


Gly Ser  Gln Asn Leu Val Tyr  Glu Thr Glu Leu Leu  Arg Thr Gln 
    3020                 3025                 3030             


Leu Asn  Asp Ser Leu Lys Glu  Ile His Gln Lys Glu  Leu Arg Ile 
    3035                 3040                 3045             


Gln Gln  Leu Asn Ser Asn Phe  Ser Gln Leu Leu Glu  Glu Lys Asn 
    3050                 3055                 3060             


Thr Leu  Ser Ile Gln Leu Cys  Asp Thr Ser Gln Ser  Leu Arg Glu 
    3065                 3070                 3075             


Asn Gln  Gln His Tyr Gly Asp  Leu Leu Asn His Cys  Ala Val Leu 
    3080                 3085                 3090             


Glu Lys  Gln Val Gln Glu Leu  Gln Ala Gly Pro Leu  Asn Ile Asp 
    3095                 3100                 3105             


Val Ala  Pro Gly Ala Pro Gln  Glu Lys Asn Gly Val  His Arg Lys 
    3110                 3115                 3120             


Ser Asp  Pro Glu Glu Leu Arg  Glu Pro Gln Gln Ser  Phe Ser Glu 
    3125                 3130                 3135             


Ala Gln  Gln Gln Leu Cys Asn  Thr Arg Gln Glu Val  Asn Glu Leu 
    3140                 3145                 3150             


Arg Lys  Leu Leu Glu Glu Glu  Arg Asp Gln Arg Val  Ala Ala Glu 
    3155                 3160                 3165             


Asn Ala  Leu Ser Val Ala Glu  Glu Gln Ile Arg Arg  Leu Glu His 
    3170                 3175                 3180             


Ser Glu  Trp Asp Ser Ser Arg  Thr Pro Ile Ile Gly  Ser Cys Gly 
    3185                 3190                 3195             


Thr Gln  Glu Gln Ala Leu Leu  Ile Asp Leu Thr Ser  Asn Ser Cys 
    3200                 3205                 3210             


Arg Arg  Thr Arg Ser Gly Val  Gly Trp Lys Arg Val  Leu Arg Ser 
    3215                 3220                 3225             


Leu Cys  His Ser Arg Thr Arg  Val Pro Leu Leu Ala  Ala Ile Tyr 
    3230                 3235                 3240             


Phe Leu  Met Ile His Val Leu  Leu Ile Leu Cys Phe  Thr Gly His 
    3245                 3250                 3255             


Leu 
    


<210>  168
<211>  649
<212>  PRT
<213>  homo sapiens

<400>  168

Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys Leu Arg Asn Leu Glu 
1               5                   10                  15      


Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu Arg Met Asn Lys Gly 
            20                  25                  30          


Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val Ser Lys Tyr Gln Glu 
        35                  40                  45              


Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu Gln Arg Ser Phe Met 
    50                  55                  60                  


Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys Lys Thr Ala Arg Arg 
65                  70                  75                  80  


Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys Arg Leu Lys Thr Val 
                85                  90                  95      


Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly Asp Asp Glu Val Arg 
            100                 105                 110         


Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro Ile Leu Ser Glu Glu 
        115                 120                 125             


Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu Val Asp Pro Glu Arg 
    130                 135                 140                 


Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu His Ala Ser Ile His 
145                 150                 155                 160 


Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro Val Cys Gly Thr Thr 
                165                 170                 175     


Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val Phe Gln Ser Asn Tyr 
            180                 185                 190         


Phe Asp Ser Thr His Asn His Gln Asn Gly Leu Cys Glu Glu Glu Glu 
        195                 200                 205             


Ala Asp Ser Ala Pro Ala Val Glu Asp Gln Val Pro Glu Ala Glu Pro 
    210                 215                 220                 


Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu Val Glu Ser Thr Glu 
225                 230                 235                 240 


Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln Phe Thr Ser Gly Glu 
                245                 250                 255     


Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr Val Glu Val Val Asn 
            260                 265                 270         


Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro Ser Val Pro Glu Pro 
        275                 280                 285             


His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro Leu Val Arg Arg Gln 
    290                 295                 300                 


Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly Pro Asp Asn Phe Ile 
305                 310                 315                 320 


Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr Leu Asp Pro Ala Ile 
                325                 330                 335     


Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn Met Asp Met Pro Gln 
            340                 345                 350         


Leu Val Cys Pro Pro Val His Ser Glu Ser Arg Leu Ala Gln Pro Asn 
        355                 360                 365             


Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val Pro Leu Val Ser Ser 
    370                 375                 380                 


Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu Tyr Gln Pro Ser His 
385                 390                 395                 400 


Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile Asp Gln Ile Gln Ala 
                405                 410                 415     


Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala Ser Ser Ser Leu Pro 
            420                 425                 430         


Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly Thr Ser Lys Pro Leu 
        435                 440                 445             


His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro Phe Gln Ser Met Gln 
    450                 455                 460                 


Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro Val Asn Glu Pro Glu 
465                 470                 475                 480 


Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser Tyr Asn Gln Ser Phe 
                485                 490                 495     


Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu Leu Gln Gln Glu Gln 
            500                 505                 510         


Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser Pro Asp Gln Ser His 
        515                 520                 525             


Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln Gln Asn Thr Gly Phe 
    530                 535                 540                 


Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg Gly Val Ser Arg Gly 
545                 550                 555                 560 


Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly Tyr Arg Gly Pro Ala 
                565                 570                 575     


Met Asp Ser Glu Glu Asp Met Met Val Thr Ala Leu His Ser Leu Thr 
            580                 585                 590         


Leu Gln Thr Val Val Ile His Ser Leu Ser Ser Val Leu Pro Gly Ile 
        595                 600                 605             


Thr Leu Ala Ile Asn Gly Met Asp Ile Ser Arg Ile Ser Ser Glu Ala 
    610                 615                 620                 


Leu Gly Arg Val Asp His Gly Glu Pro His Glu Val Val Glu Gly Pro 
625                 630                 635                 640 


Gln Asp Pro Thr Glu Gly Cys Arg Lys 
                645                 


<210>  169
<211>  1017
<212>  PRT
<213>  homo sapiens

<400>  169

Met Lys Leu Leu Lys Pro Thr Trp Val Asn His Asn Gly Lys Pro Ile 
1               5                   10                  15      


Phe Ser Val Asp Ile His Pro Asp Gly Thr Lys Phe Ala Thr Gly Gly 
            20                  25                  30          


Gln Gly Gln Asp Ser Gly Lys Val Val Ile Trp Asn Met Ser Pro Val 
        35                  40                  45              


Leu Gln Glu Asp Asp Glu Lys Asp Glu Asn Ile Pro Lys Met Leu Cys 
    50                  55                  60                  


Gln Met Asp Asn His Leu Ala Cys Val Asn Cys Val Arg Trp Ser Asn 
65                  70                  75                  80  


Ser Gly Met Tyr Leu Ala Ser Gly Gly Asp Asp Lys Leu Ile Met Val 
                85                  90                  95      


Trp Lys Arg Ala Thr Tyr Ile Gly Pro Ser Thr Val Phe Gly Ser Ser 
            100                 105                 110         


Gly Lys Leu Ala Asn Val Glu Gln Trp Arg Cys Val Ser Ile Leu Arg 
        115                 120                 125             


Asn His Ser Gly Asp Val Met Asp Val Ala Trp Ser Pro His Asp Ala 
    130                 135                 140                 


Trp Leu Ala Ser Cys Ser Val Asp Asn Thr Val Val Ile Trp Asn Ala 
145                 150                 155                 160 


Val Lys Phe Pro Glu Ile Leu Ala Thr Leu Arg Gly His Ser Gly Leu 
                165                 170                 175     


Val Lys Gly Leu Thr Trp Asp Pro Val Gly Lys Tyr Ile Ala Ser Gln 
            180                 185                 190         


Ala Asp Asp Arg Ser Leu Lys Val Trp Arg Thr Leu Asp Trp Gln Leu 
        195                 200                 205             


Glu Thr Ser Ile Thr Lys Pro Phe Asp Glu Cys Gly Gly Thr Thr His 
    210                 215                 220                 


Val Leu Arg Leu Ser Trp Ser Pro Asp Gly His Tyr Leu Val Ser Ala 
225                 230                 235                 240 


His Ala Met Asn Asn Ser Gly Pro Thr Ala Gln Ile Ile Glu Arg Glu 
                245                 250                 255     


Gly Trp Lys Thr Asn Met Asp Phe Val Gly His Arg Lys Ala Val Thr 
            260                 265                 270         


Val Val Lys Phe Asn Pro Lys Ile Phe Lys Lys Lys Gln Lys Asn Gly 
        275                 280                 285             


Ser Ser Ala Lys Pro Ser Cys Pro Tyr Cys Cys Cys Ala Val Gly Ser 
    290                 295                 300                 


Lys Asp Arg Ser Leu Ser Val Trp Leu Thr Cys Leu Lys Arg Pro Leu 
305                 310                 315                 320 


Val Val Ile His Glu Leu Phe Asp Lys Ser Ile Met Asp Ile Ser Trp 
                325                 330                 335     


Thr Leu Asn Gly Leu Gly Ile Leu Val Cys Ser Met Asp Gly Ser Val 
            340                 345                 350         


Ala Phe Leu Asp Phe Ser Gln Asp Glu Leu Gly Asp Pro Leu Ser Glu 
        355                 360                 365             


Glu Glu Lys Ser Arg Ile His Gln Ser Thr Tyr Gly Lys Ser Leu Ala 
    370                 375                 380                 


Ile Met Thr Glu Ala Gln Leu Ser Thr Ala Val Ile Glu Asn Pro Glu 
385                 390                 395                 400 


Met Leu Lys Tyr Gln Arg Arg Gln Gln Gln Gln Gln Leu Asp Gln Lys 
                405                 410                 415     


Ser Ala Ala Thr Arg Glu Met Gly Ser Ala Thr Ser Val Ala Gly Val 
            420                 425                 430         


Val Asn Gly Glu Ser Leu Glu Asp Ile Arg Lys Asn Leu Leu Lys Lys 
        435                 440                 445             


Gln Val Glu Thr Arg Thr Ala Asp Gly Arg Arg Arg Ile Thr Pro Leu 
    450                 455                 460                 


Cys Ile Ala Gln Leu Asp Thr Gly Asp Phe Ser Thr Ala Phe Phe Asn 
465                 470                 475                 480 


Ser Ile Pro Leu Ser Gly Ser Leu Ala Gly Thr Met Leu Ser Ser His 
                485                 490                 495     


Ser Ser Pro Gln Leu Leu Pro Leu Asp Ser Ser Thr Pro Asn Ser Phe 
            500                 505                 510         


Gly Ala Ser Lys Pro Cys Thr Glu Pro Val Val Ala Ala Ser Ala Arg 
        515                 520                 525             


Pro Ala Gly Asp Ser Val Asn Lys Asp Ser Met Asn Ala Thr Ser Thr 
    530                 535                 540                 


Pro Ala Ala Leu Ser Pro Ser Val Leu Thr Thr Pro Ser Lys Ile Glu 
545                 550                 555                 560 


Pro Met Lys Ala Phe Asp Ser Arg Phe Thr Glu Arg Ser Lys Ala Thr 
                565                 570                 575     


Pro Gly Ala Pro Ala Leu Thr Ser Met Thr Pro Thr Ala Val Glu Arg 
            580                 585                 590         


Leu Lys Glu Gln Asn Leu Val Lys Glu Leu Arg Pro Arg Asp Leu Leu 
        595                 600                 605             


Glu Ser Ser Ser Asp Ser Asp Glu Lys Val Pro Leu Ala Lys Ala Ser 
    610                 615                 620                 


Ser Leu Ser Lys Arg Lys Leu Glu Leu Glu Val Glu Thr Val Glu Lys 
625                 630                 635                 640 


Lys Lys Lys Gly Arg Pro Arg Lys Asp Ser Arg Leu Met Pro Val Ser 
                645                 650                 655     


Leu Ser Val Gln Ser Pro Ala Ala Leu Thr Ala Glu Lys Glu Ala Met 
            660                 665                 670         


Cys Leu Ser Ala Pro Ala Leu Ala Leu Lys Leu Pro Ile Pro Ser Pro 
        675                 680                 685             


Gln Arg Ala Phe Thr Leu Gln Val Ser Ser Asp Pro Ser Met Tyr Ile 
    690                 695                 700                 


Glu Val Glu Asn Glu Val Thr Val Val Gly Gly Val Lys Leu Ser Arg 
705                 710                 715                 720 


Leu Lys Cys Asn Arg Glu Gly Lys Glu Trp Glu Thr Val Leu Thr Ser 
                725                 730                 735     


Arg Ile Leu Thr Ala Ala Gly Ser Cys Asp Val Val Cys Val Ala Cys 
            740                 745                 750         


Glu Lys Arg Met Leu Ser Val Phe Ser Thr Cys Gly Arg Arg Leu Leu 
        755                 760                 765             


Ser Pro Ile Leu Leu Pro Ser Pro Ile Ser Thr Leu His Cys Thr Gly 
    770                 775                 780                 


Ser Tyr Val Met Ala Leu Thr Ala Ala Ala Thr Leu Ser Val Trp Asp 
785                 790                 795                 800 


Val His Arg Gln Val Val Val Val Lys Glu Glu Ser Leu His Ser Ile 
                805                 810                 815     


Leu Ala Gly Ser Asp Met Thr Val Ser Gln Ile Leu Leu Thr Gln His 
            820                 825                 830         


Gly Ile Pro Val Met Asn Leu Ser Asp Gly Lys Ala Tyr Cys Phe Asn 
        835                 840                 845             


Pro Ser Leu Ser Thr Trp Asn Leu Val Ser Asp Lys Gln Asp Ser Leu 
    850                 855                 860                 


Ala Gln Cys Ala Asp Phe Arg Ser Ser Leu Pro Ser Gln Asp Ala Met 
865                 870                 875                 880 


Leu Cys Ser Gly Pro Leu Ala Ile Ile Gln Gly Arg Thr Ser Asn Ser 
                885                 890                 895     


Gly Arg Gln Ala Ala Arg Leu Phe Ser Val Pro His Val Val Gln Gln 
            900                 905                 910         


Glu Thr Thr Leu Ala Tyr Leu Glu Asn Gln Val Ala Ala Ala Leu Thr 
        915                 920                 925             


Leu Gln Ser Ser His Glu Tyr Arg His Trp Leu Leu Val Tyr Ala Arg 
    930                 935                 940                 


Tyr Leu Val Asn Glu Gly Phe Glu Tyr Arg Leu Arg Glu Ile Cys Lys 
945                 950                 955                 960 


Asp Leu Leu Gly Pro Val His Tyr Ser Thr Gly Ser Gln Trp Glu Ser 
                965                 970                 975     


Thr Val Val Gly Leu Arg Lys Arg Glu Leu Leu Lys Glu Leu Leu Pro 
            980                 985                 990         


Val Ile Gly Gln Asn Leu Arg Phe  Gln Arg Leu Phe Thr  Glu Cys Gln 
        995                 1000                 1005             


Glu Gln  Leu Asp Ile Leu Arg  Asp Lys 
    1010                 1015         


<210>  170
<211>  1210
<212>  PRT
<213>  homo sapiens

<400>  170

Met Ala Ser Gln Leu Gln Val Phe Ser Pro Pro Ser Val Ser Ser Ser 
1               5                   10                  15      


Ala Phe Cys Ser Ala Lys Lys Leu Lys Ile Glu Pro Ser Gly Trp Asp 
            20                  25                  30          


Val Ser Gly Gln Ser Ser Asn Asp Lys Tyr Tyr Thr His Ser Lys Thr 
        35                  40                  45              


Leu Pro Ala Thr Gln Gly Gln Ala Asn Ser Ser His Gln Val Ala Asn 
    50                  55                  60                  


Phe Asn Ile Pro Ala Tyr Asp Gln Gly Leu Leu Leu Pro Ala Pro Ala 
65                  70                  75                  80  


Val Glu His Ile Val Val Thr Ala Ala Asp Ser Ser Gly Ser Ala Ala 
                85                  90                  95      


Thr Ser Thr Phe Gln Ser Ser Gln Thr Leu Thr His Arg Ser Asn Val 
            100                 105                 110         


Ser Leu Leu Glu Pro Tyr Gln Lys Cys Gly Leu Lys Arg Lys Ser Glu 
        115                 120                 125             


Glu Val Asp Ser Asn Gly Ser Val Gln Ile Ile Glu Glu His Pro Pro 
    130                 135                 140                 


Leu Met Leu Gln Asn Arg Thr Val Val Gly Ala Ala Ala Thr Thr Thr 
145                 150                 155                 160 


Thr Val Thr Thr Lys Ser Ser Ser Ser Ser Gly Glu Gly Asp Tyr Gln 
                165                 170                 175     


Leu Val Gln His Glu Ile Leu Cys Ser Met Thr Asn Ser Tyr Glu Val 
            180                 185                 190         


Leu Glu Phe Leu Gly Arg Gly Thr Phe Gly Gln Val Ala Lys Cys Trp 
        195                 200                 205             


Lys Arg Ser Thr Lys Glu Ile Val Ala Ile Lys Ile Leu Lys Asn His 
    210                 215                 220                 


Pro Ser Tyr Ala Arg Gln Gly Gln Ile Glu Val Ser Ile Leu Ser Arg 
225                 230                 235                 240 


Leu Ser Ser Glu Asn Ala Asp Glu Tyr Asn Phe Val Arg Ser Tyr Glu 
                245                 250                 255     


Cys Phe Gln His Lys Asn His Thr Cys Leu Val Phe Glu Met Leu Glu 
            260                 265                 270         


Gln Asn Leu Tyr Asp Phe Leu Lys Gln Asn Lys Phe Ser Pro Leu Pro 
        275                 280                 285             


Leu Lys Tyr Ile Arg Pro Ile Leu Gln Gln Val Ala Thr Ala Leu Met 
    290                 295                 300                 


Lys Leu Lys Ser Leu Gly Leu Ile His Ala Asp Leu Lys Pro Glu Asn 
305                 310                 315                 320 


Ile Met Leu Val Asp Pro Val Arg Gln Pro Tyr Arg Val Lys Val Ile 
                325                 330                 335     


Asp Phe Gly Ser Ala Ser His Val Ser Lys Ala Val Cys Ser Thr Tyr 
            340                 345                 350         


Leu Gln Ser Arg Tyr Tyr Arg Ala Pro Glu Ile Ile Leu Gly Leu Pro 
        355                 360                 365             


Phe Cys Glu Ala Ile Asp Met Trp Ser Leu Gly Cys Val Ile Ala Glu 
    370                 375                 380                 


Leu Phe Leu Gly Trp Pro Leu Tyr Pro Gly Ala Ser Glu Tyr Asp Gln 
385                 390                 395                 400 


Ile Arg Tyr Ile Ser Gln Thr Gln Gly Leu Pro Ala Glu Tyr Leu Leu 
                405                 410                 415     


Ser Ala Gly Thr Lys Thr Thr Arg Phe Phe Asn Arg Asp Pro Asn Leu 
            420                 425                 430         


Gly Tyr Pro Leu Trp Arg Leu Lys Thr Pro Glu Glu His Glu Leu Glu 
        435                 440                 445             


Thr Gly Ile Lys Ser Lys Glu Ala Arg Lys Tyr Ile Phe Asn Cys Leu 
    450                 455                 460                 


Asp Asp Met Ala Gln Val Asn Met Ser Thr Asp Leu Glu Gly Thr Asp 
465                 470                 475                 480 


Met Leu Ala Glu Lys Ala Asp Arg Arg Glu Tyr Ile Asp Leu Leu Lys 
                485                 490                 495     


Lys Met Leu Thr Ile Asp Ala Asp Lys Arg Ile Thr Pro Leu Lys Thr 
            500                 505                 510         


Leu Asn His Gln Phe Val Thr Met Thr His Leu Leu Asp Phe Pro His 
        515                 520                 525             


Ser Asn His Val Lys Ser Cys Phe Gln Asn Met Glu Ile Cys Lys Arg 
    530                 535                 540                 


Arg Val His Met Tyr Asp Thr Val Ser Gln Ile Lys Ser Pro Phe Thr 
545                 550                 555                 560 


Thr His Val Ala Pro Asn Thr Ser Thr Asn Leu Thr Met Ser Phe Ser 
                565                 570                 575     


Asn Gln Leu Asn Thr Val His Asn Gln Ala Ser Val Leu Ala Ser Ser 
            580                 585                 590         


Ser Thr Ala Ala Ala Ala Thr Leu Ser Leu Ala Asn Ser Asp Val Ser 
        595                 600                 605             


Leu Leu Asn Tyr Gln Ser Ala Leu Tyr Pro Ser Ser Ala Ala Pro Val 
    610                 615                 620                 


Pro Gly Val Ala Gln Gln Gly Val Ser Leu Gln Pro Gly Thr Thr Gln 
625                 630                 635                 640 


Ile Cys Thr Gln Thr Asp Pro Phe Gln Gln Thr Phe Ile Val Cys Pro 
                645                 650                 655     


Pro Ala Phe Gln Thr Gly Leu Gln Ala Thr Thr Lys His Ser Gly Phe 
            660                 665                 670         


Pro Val Arg Met Asp Asn Ala Val Pro Ile Val Pro Gln Ala Pro Ala 
        675                 680                 685             


Ala Gln Pro Leu Gln Ile Gln Ser Gly Val Leu Thr Gln Gly Ser Cys 
    690                 695                 700                 


Thr Pro Leu Met Val Ala Thr Leu His Pro Gln Val Ala Thr Ile Thr 
705                 710                 715                 720 


Pro Gln Tyr Ala Val Pro Phe Thr Leu Ser Cys Ala Ala Gly Arg Pro 
                725                 730                 735     


Ala Leu Val Glu Gln Thr Ala Ala Val Leu Gln Ala Trp Pro Gly Gly 
            740                 745                 750         


Thr Gln Gln Ile Leu Leu Pro Ser Thr Trp Gln Gln Leu Pro Gly Val 
        755                 760                 765             


Ala Leu His Asn Ser Val Gln Pro Thr Ala Met Ile Pro Glu Ala Met 
    770                 775                 780                 


Gly Ser Gly Gln Gln Leu Ala Asp Trp Arg Asn Ala His Ser His Gly 
785                 790                 795                 800 


Asn Gln Tyr Ser Thr Ile Met Gln Gln Pro Ser Leu Leu Thr Asn His 
                805                 810                 815     


Val Thr Leu Ala Thr Ala Gln Pro Leu Asn Val Gly Val Ala His Val 
            820                 825                 830         


Val Arg Gln Gln Gln Ser Ser Ser Leu Pro Ser Lys Lys Asn Lys Gln 
        835                 840                 845             


Ser Ala Pro Val Ser Ser Lys Ser Ser Leu Asp Val Leu Pro Ser Gln 
    850                 855                 860                 


Val Tyr Ser Leu Val Gly Ser Ser Pro Leu Arg Thr Thr Ser Ser Tyr 
865                 870                 875                 880 


Asn Ser Leu Val Pro Val Gln Asp Gln His Gln Pro Ile Ile Ile Pro 
                885                 890                 895     


Asp Thr Pro Ser Pro Pro Val Ser Val Ile Thr Ile Arg Ser Asp Thr 
            900                 905                 910         


Asp Glu Glu Glu Asp Asn Lys Tyr Lys Pro Ser Ser Ser Gly Leu Lys 
        915                 920                 925             


Pro Arg Ser Asn Val Ile Ser Tyr Val Thr Val Asn Asp Ser Pro Asp 
    930                 935                 940                 


Ser Asp Ser Ser Leu Ser Ser Pro Tyr Ser Thr Asp Thr Leu Ser Ala 
945                 950                 955                 960 


Leu Arg Gly Asn Ser Gly Ser Val Leu Glu Gly Pro Gly Arg Val Val 
                965                 970                 975     


Ala Asp Gly Thr Gly Thr Arg Thr Ile Ile Val Pro Pro Leu Lys Thr 
            980                 985                 990         


Gln Leu Gly Asp Cys Thr Val Ala  Thr Gln Ala Ser Gly  Leu Leu Ser 
        995                 1000                 1005             


Asn Lys  Thr Lys Pro Val Ala  Ser Val Ser Gly Gln  Ser Ser Gly 
    1010                 1015                 1020             


Cys Cys  Ile Thr Pro Thr Gly  Tyr Arg Ala Gln Arg  Gly Gly Thr 
    1025                 1030                 1035             


Ser Ala  Ala Gln Pro Leu Asn  Leu Ser Gln Asn Gln  Gln Ser Ser 
    1040                 1045                 1050             


Ala Ala  Pro Thr Ser Gln Glu  Arg Ser Ser Asn Pro  Ala Pro Arg 
    1055                 1060                 1065             


Arg Gln  Gln Ala Phe Val Ala  Pro Leu Ser Gln Ala  Pro Tyr Thr 
    1070                 1075                 1080             


Phe Gln  His Gly Ser Pro Leu  His Ser Thr Gly His  Pro His Leu 
    1085                 1090                 1095             


Ala Pro  Ala Pro Ala His Leu  Pro Ser Gln Ala His  Leu Tyr Thr 
    1100                 1105                 1110             


Tyr Ala  Ala Pro Thr Ser Ala  Ala Ala Leu Gly Ser  Thr Ser Ser 
    1115                 1120                 1125             


Ile Ala  His Leu Phe Ser Pro  Gln Gly Ser Ser Arg  His Ala Ala 
    1130                 1135                 1140             


Ala Tyr  Thr Thr His Pro Ser  Thr Leu Val His Gln  Val Pro Val 
    1145                 1150                 1155             


Ser Val  Gly Pro Ser Leu Leu  Thr Ser Ala Ser Val  Ala Pro Ala 
    1160                 1165                 1170             


Gln Tyr  Gln His Gln Phe Ala  Thr Gln Ser Tyr Ile  Gly Ser Ser 
    1175                 1180                 1185             


Arg Gly  Ser Thr Ile Tyr Thr  Gly Tyr Pro Leu Ser  Pro Thr Lys 
    1190                 1195                 1200             


Ile Ser  Gln Tyr Ser Tyr Leu  
    1205                 1210 


<210>  171
<211>  1068
<212>  PRT
<213>  homo sapiens

<400>  171

Met Asn Ser Ile Lys Asn Val Pro Ala Arg Val Leu Ser Arg Arg Pro 
1               5                   10                  15      


Gly His Ser Leu Glu Ala Glu Arg Glu Gln Phe Asp Lys Thr Gln Ala 
            20                  25                  30          


Ile Ser Ile Ser Lys Ala Ile Asn Thr Gln Glu Ala Pro Val Lys Glu 
        35                  40                  45              


Lys His Ala Arg Arg Ile Ile Leu Gly Thr His His Glu Lys Gly Ala 
    50                  55                  60                  


Phe Thr Phe Trp Ser Tyr Ala Ile Gly Leu Pro Leu Pro Ser Ser Ser 
65                  70                  75                  80  


Ile Leu Ser Trp Lys Phe Cys His Val Leu His Lys Val Leu Arg Asp 
                85                  90                  95      


Gly His Pro Asn Val Leu His Asp Cys Gln Arg Tyr Arg Ser Asn Ile 
            100                 105                 110         


Arg Glu Ile Gly Asp Leu Trp Gly His Leu His Asp Arg Tyr Gly Gln 
        115                 120                 125             


Leu Val Asn Val Tyr Thr Lys Leu Leu Leu Thr Lys Ile Ser Phe His 
    130                 135                 140                 


Leu Lys His Pro Gln Phe Pro Ala Gly Leu Glu Val Thr Asp Glu Val 
145                 150                 155                 160 


Leu Glu Lys Ala Ala Gly Thr Asp Val Asn Asn Ile Phe Gln Leu Thr 
                165                 170                 175     


Val Glu Met Phe Asp Tyr Met Asp Cys Glu Leu Lys Leu Ser Glu Ser 
            180                 185                 190         


Val Phe Arg Gln Leu Asn Thr Ala Ile Ala Val Ser Gln Met Ser Ser 
        195                 200                 205             


Gly Gln Cys Arg Leu Ala Pro Leu Ile Gln Val Ile Gln Asp Cys Ser 
    210                 215                 220                 


His Leu Tyr His Tyr Thr Val Lys Leu Leu Phe Lys Leu His Ser Cys 
225                 230                 235                 240 


Leu Pro Ala Asp Thr Leu Gln Gly His Arg Asp Arg Phe His Glu Gln 
                245                 250                 255     


Phe His Ser Leu Arg Asn Phe Phe Arg Arg Ala Ser Asp Met Leu Tyr 
            260                 265                 270         


Phe Lys Arg Leu Ile Gln Ile Pro Arg Leu Pro Glu Gly Pro Pro Asn 
        275                 280                 285             


Phe Leu Arg Ala Ser Ala Leu Ala Glu His Ile Lys Pro Val Val Val 
    290                 295                 300                 


Ile Pro Glu Glu Ala Pro Glu Asp Glu Glu Pro Glu Asn Leu Ile Glu 
305                 310                 315                 320 


Ile Ser Thr Gly Pro Pro Ala Gly Glu Pro Val Val Val Ala Asp Leu 
                325                 330                 335     


Phe Asp Gln Thr Phe Gly Pro Pro Asn Gly Ser Val Lys Asp Asp Arg 
            340                 345                 350         


Asp Leu Gln Ile Glu Ser Leu Lys Arg Glu Val Glu Met Leu Arg Ser 
        355                 360                 365             


Glu Leu Glu Lys Ile Lys Leu Glu Ala Gln Arg Tyr Ile Ala Gln Leu 
    370                 375                 380                 


Lys Ser Gln Val Asn Ala Leu Glu Gly Glu Leu Glu Glu Gln Arg Lys 
385                 390                 395                 400 


Gln Lys Gln Lys Ala Leu Val Asp Asn Glu Gln Leu Arg His Glu Leu 
                405                 410                 415     


Ala Gln Leu Arg Ala Ala Gln Leu Glu Gly Glu Arg Ser Gln Gly Leu 
            420                 425                 430         


Arg Glu Glu Ala Glu Arg Lys Ala Ser Ala Thr Glu Ala Arg Tyr Asn 
        435                 440                 445             


Lys Leu Lys Glu Lys His Ser Glu Leu Val His Val His Ala Glu Leu 
    450                 455                 460                 


Leu Arg Lys Asn Ala Asp Thr Ala Lys Gln Leu Thr Val Thr Gln Gln 
465                 470                 475                 480 


Ser Gln Glu Glu Val Ala Arg Val Lys Glu Gln Leu Ala Phe Gln Val 
                485                 490                 495     


Glu Gln Val Lys Arg Glu Ser Glu Leu Lys Leu Glu Glu Lys Ser Asp 
            500                 505                 510         


Gln Leu Glu Lys Leu Lys Arg Glu Leu Glu Ala Lys Ala Gly Glu Leu 
        515                 520                 525             


Ala Arg Ala Gln Glu Ala Leu Ser His Thr Glu Gln Ser Lys Ser Glu 
    530                 535                 540                 


Leu Ser Ser Arg Leu Asp Thr Leu Ser Ala Glu Lys Asp Ala Leu Ser 
545                 550                 555                 560 


Gly Ala Val Arg Gln Arg Glu Ala Asp Leu Leu Ala Ala Gln Ser Leu 
                565                 570                 575     


Val Arg Glu Thr Glu Ala Ala Leu Ser Arg Glu Gln Gln Arg Ser Ser 
            580                 585                 590         


Gln Glu Gln Gly Glu Leu Gln Gly Arg Leu Ala Glu Arg Glu Ser Gln 
        595                 600                 605             


Glu Gln Gly Leu Arg Gln Arg Leu Leu Asp Glu Gln Phe Ala Val Leu 
    610                 615                 620                 


Arg Gly Ala Ala Ala Glu Ala Ala Gly Ile Leu Gln Asp Ala Val Ser 
625                 630                 635                 640 


Lys Leu Asp Asp Pro Leu His Leu Arg Cys Thr Ser Ser Pro Asp Tyr 
                645                 650                 655     


Leu Val Ser Arg Ala Gln Glu Ala Leu Asp Ala Val Ser Thr Leu Glu 
            660                 665                 670         


Glu Gly His Ala Gln Tyr Leu Thr Ser Leu Ala Asp Ala Ser Ala Leu 
        675                 680                 685             


Val Ala Ala Leu Thr Arg Phe Ser His Leu Ala Ala Asp Thr Ile Ile 
    690                 695                 700                 


Asn Gly Gly Ala Thr Ser His Leu Ala Pro Thr Asp Pro Ala Asp Arg 
705                 710                 715                 720 


Leu Ile Asp Thr Cys Arg Glu Cys Gly Ala Arg Ala Leu Glu Leu Met 
                725                 730                 735     


Gly Gln Leu Gln Asp Gln Gln Ala Leu Arg His Met Gln Ala Ser Leu 
            740                 745                 750         


Val Arg Thr Pro Leu Gln Gly Ile Leu Gln Leu Gly Gln Glu Leu Lys 
        755                 760                 765             


Pro Lys Ser Leu Asp Val Arg Gln Glu Glu Leu Gly Ala Val Val Asp 
    770                 775                 780                 


Lys Glu Met Ala Ala Thr Ser Ala Ala Ile Glu Asp Ala Val Arg Arg 
785                 790                 795                 800 


Ile Glu Asp Met Met Asn Gln Ala Arg His Ala Ser Ser Gly Val Lys 
                805                 810                 815     


Leu Glu Val Asn Glu Arg Ile Leu Asn Ser Cys Thr Asp Leu Met Lys 
            820                 825                 830         


Ala Ile Arg Leu Leu Val Thr Thr Ser Thr Ser Leu Gln Lys Glu Ile 
        835                 840                 845             


Val Glu Ser Gly Arg Gly Ala Ala Thr Gln Gln Glu Phe Tyr Ala Lys 
    850                 855                 860                 


Asn Ser Arg Trp Thr Glu Gly Leu Ile Ser Ala Ser Lys Ala Val Gly 
865                 870                 875                 880 


Trp Gly Ala Thr Gln Leu Val Glu Ala Ala Asp Lys Val Val Leu His 
                885                 890                 895     


Thr Gly Lys Tyr Glu Glu Leu Ile Val Cys Ser His Glu Ile Ala Ala 
            900                 905                 910         


Ser Thr Ala Gln Leu Val Ala Ala Ser Lys Val Lys Ala Asn Lys His 
        915                 920                 925             


Ser Pro His Leu Ser Arg Leu Gln Glu Cys Ser Arg Thr Val Asn Glu 
    930                 935                 940                 


Arg Ala Ala Asn Val Val Ala Ser Thr Lys Ser Gly Gln Glu Gln Ile 
945                 950                 955                 960 


Glu Asp Arg Asp Thr Met Asp Phe Ser Gly Leu Ser Leu Ile Lys Leu 
                965                 970                 975     


Lys Lys Gln Glu Met Glu Thr Gln Val Arg Val Leu Glu Leu Glu Lys 
            980                 985                 990         


Thr Leu Glu Ala Glu Arg Met Arg  Leu Gly Glu Leu Arg  Lys Gln His 
        995                 1000                 1005             


Tyr Val  Leu Ala Gly Ala Ser  Gly Ser Pro Gly Glu  Glu Val Ala 
    1010                 1015                 1020             


Ile Arg  Pro Ser Thr Ala Pro  Arg Ser Val Thr Thr  Lys Lys Pro 
    1025                 1030                 1035             


Pro Leu  Ala Gln Lys Pro Ser  Val Ala Pro Arg Gln  Asp His Gln 
    1040                 1045                 1050             


Leu Asp  Lys Lys Asp Gly Ile  Tyr Pro Ala Gln Leu  Val Asn Tyr 
    1055                 1060                 1065             


<210>  172
<211>  1130
<212>  PRT
<213>  homo sapiens

<400>  172

Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu 
1               5                   10                  15      


Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn 
            20                  25                  30          


Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu 
        35                  40                  45              


Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Pro Arg Gly Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr 
65                  70                  75                  80  


Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg 
                85                  90                  95      


Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp 
            100                 105                 110         


Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val 
        115                 120                 125             


Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys 
    130                 135                 140                 


Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp 
                165                 170                 175     


Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val 
            180                 185                 190         


Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro 
        195                 200                 205             


Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn 
    210                 215                 220                 


Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly 
225                 230                 235                 240 


Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser 
                245                 250                 255     


Tyr Leu Gly Leu Leu Phe Leu Thr Ser Val Ser Tyr Thr Asp Pro Asp 
            260                 265                 270         


Gln Phe Val Tyr Lys Thr Arg Pro Pro Arg Glu Gln Pro Asp Thr Phe 
        275                 280                 285             


Pro Asp Val Met Met Asn Ser Tyr Leu Gly Phe Ser Leu Asp Ser Gly 
    290                 295                 300                 


Lys Gly Ile Val Ser Lys Asp Glu Ile Thr Phe Val Ser Gly Ala Pro 
305                 310                 315                 320 


Arg Ala Asn His Ser Gly Ala Val Val Leu Leu Lys Arg Asp Met Lys 
                325                 330                 335     


Ser Ala His Leu Leu Pro Glu His Ile Phe Asp Gly Glu Gly Leu Ala 
            340                 345                 350         


Ser Ser Phe Gly Tyr Asp Val Ala Val Val Asp Leu Asn Lys Asp Gly 
        355                 360                 365             


Trp Gln Asp Ile Val Ile Gly Ala Pro Gln Tyr Phe Asp Arg Asp Gly 
    370                 375                 380                 


Glu Val Gly Gly Ala Val Tyr Val Tyr Met Asn Gln Gln Gly Arg Trp 
385                 390                 395                 400 


Asn Asn Val Lys Pro Ile Arg Leu Asn Gly Thr Lys Asp Ser Met Phe 
                405                 410                 415     


Gly Ile Ala Val Lys Asn Ile Gly Asp Ile Asn Gln Asp Gly Tyr Pro 
            420                 425                 430         


Asp Ile Ala Val Gly Ala Pro Tyr Asp Asp Leu Gly Lys Val Phe Ile 
        435                 440                 445             


Tyr His Gly Ser Ala Asn Gly Ile Asn Thr Lys Pro Thr Gln Val Leu 
    450                 455                 460                 


Lys Gly Ile Ser Pro Tyr Phe Gly Tyr Ser Ile Ala Gly Asn Met Asp 
465                 470                 475                 480 


Leu Asp Arg Asn Ser Tyr Pro Asp Val Ala Val Gly Ser Leu Ser Asp 
                485                 490                 495     


Ser Val Thr Ile Phe Arg Ser Arg Pro Val Ile Asn Ile Gln Lys Thr 
            500                 505                 510         


Ile Thr Val Thr Pro Asn Arg Ile Asp Leu Arg Gln Lys Thr Ala Cys 
        515                 520                 525             


Gly Ala Pro Ser Gly Ile Cys Leu Gln Val Lys Ser Cys Phe Glu Tyr 
    530                 535                 540                 


Thr Ala Asn Pro Ala Gly Tyr Asn Pro Ser Ile Ser Ile Val Gly Thr 
545                 550                 555                 560 


Leu Glu Ala Glu Lys Glu Arg Arg Lys Ser Gly Leu Ser Ser Arg Val 
                565                 570                 575     


Gln Phe Arg Asn Gln Gly Ser Glu Pro Lys Tyr Thr Gln Glu Leu Thr 
            580                 585                 590         


Leu Lys Arg Gln Lys Gln Lys Val Cys Met Glu Glu Thr Leu Trp Leu 
        595                 600                 605             


Gln Asp Asn Ile Arg Asp Lys Leu Arg Pro Ile Pro Ile Thr Ala Ser 
    610                 615                 620                 


Val Glu Ile Gln Glu Pro Ser Ser Arg Arg Arg Val Asn Ser Leu Pro 
625                 630                 635                 640 


Glu Val Leu Pro Ile Leu Asn Ser Asp Glu Pro Lys Thr Ala His Ile 
                645                 650                 655     


Asp Val His Phe Leu Lys Glu Gly Cys Gly Asp Asp Asn Val Cys Asn 
            660                 665                 670         


Ser Asn Leu Lys Leu Glu Tyr Lys Phe Cys Thr Arg Glu Gly Asn Gln 
        675                 680                 685             


Asp Lys Phe Ser Tyr Leu Pro Ile Gln Lys Gly Val Pro Glu Leu Val 
    690                 695                 700                 


Leu Lys Asp Gln Lys Asp Ile Ala Leu Glu Ile Thr Val Thr Asn Ser 
705                 710                 715                 720 


Pro Ser Asn Pro Arg Asn Pro Thr Lys Asp Gly Asp Asp Ala His Glu 
                725                 730                 735     


Ala Lys Leu Ile Ala Thr Phe Pro Asp Thr Leu Thr Tyr Ser Ala Tyr 
            740                 745                 750         


Arg Glu Leu Arg Ala Phe Pro Glu Lys Gln Leu Ser Cys Val Ala Asn 
        755                 760                 765             


Gln Asn Gly Ser Gln Ala Asp Cys Glu Leu Gly Asn Pro Phe Lys Arg 
    770                 775                 780                 


Asn Ser Asn Val Thr Phe Tyr Leu Val Leu Ser Thr Thr Glu Val Thr 
785                 790                 795                 800 


Phe Asp Thr Pro Asp Leu Asp Ile Asn Leu Lys Leu Glu Thr Thr Ser 
                805                 810                 815     


Asn Gln Asp Asn Leu Ala Pro Ile Thr Ala Lys Ala Lys Val Val Ile 
            820                 825                 830         


Glu Leu Leu Leu Ser Val Ser Gly Val Ala Lys Pro Ser Gln Val Tyr 
        835                 840                 845             


Phe Gly Gly Thr Val Val Gly Glu Gln Ala Met Lys Ser Glu Asp Glu 
    850                 855                 860                 


Val Gly Ser Leu Ile Glu Tyr Glu Phe Arg Val Ile Asn Leu Gly Lys 
865                 870                 875                 880 


Pro Leu Thr Asn Leu Gly Thr Ala Thr Leu Asn Ile Gln Trp Pro Lys 
                885                 890                 895     


Glu Ile Ser Asn Gly Lys Trp Leu Leu Tyr Leu Val Lys Val Glu Ser 
            900                 905                 910         


Lys Gly Leu Glu Lys Val Thr Cys Glu Pro Gln Lys Glu Ile Asn Ser 
        915                 920                 925             


Leu Asn Leu Thr Glu Ser His Asn Ser Arg Lys Lys Arg Glu Ile Thr 
    930                 935                 940                 


Glu Lys Gln Ile Asp Asp Asn Arg Lys Phe Ser Leu Phe Ala Glu Arg 
945                 950                 955                 960 


Lys Tyr Gln Thr Leu Asn Cys Ser Val Asn Val Asn Cys Val Asn Ile 
                965                 970                 975     


Arg Cys Pro Leu Arg Gly Leu Asp Ser Lys Ala Ser Leu Ile Leu Arg 
            980                 985                 990         


Ser Arg Leu Trp Asn Ser Thr Phe  Leu Glu Glu Tyr Ser  Lys Leu Asn 
        995                 1000                 1005             


Tyr Leu  Asp Ile Leu Met Arg  Ala Phe Ile Asp Val  Thr Ala Ala 
    1010                 1015                 1020             


Ala Glu  Asn Ile Arg Leu Pro  Asn Ala Gly Thr Gln  Val Arg Val 
    1025                 1030                 1035             


Thr Val  Phe Pro Ser Lys Thr  Val Ala Gln Tyr Ser  Gly Val Pro 
    1040                 1045                 1050             


Trp Trp  Ile Ile Leu Val Ala  Ile Leu Ala Gly Ile  Leu Met Leu 
    1055                 1060                 1065             


Ala Leu  Leu Val Phe Ile Leu  Trp Lys Cys Gly Phe  Phe Lys Arg 
    1070                 1075                 1080             


Ser Arg  Tyr Asp Asp Ser Val  Pro Arg Tyr His Ala  Val Arg Ile 
    1085                 1090                 1095             


Arg Lys  Glu Glu Arg Glu Ile  Lys Asp Glu Lys Tyr  Ile Asp Asn 
    1100                 1105                 1110             


Leu Glu  Lys Lys Gln Trp Ile  Thr Lys Trp Asn Arg  Asn Glu Ser 
    1115                 1120                 1125             


Tyr Ser  
    1130 


<210>  173
<211>  625
<212>  PRT
<213>  homo sapiens

<400>  173

Met Ala Cys Tyr Ile Tyr Gln Leu Pro Ser Trp Val Leu Asp Asp Leu 
1               5                   10                  15      


Cys Arg Asn Met Asp Ala Leu Ser Glu Trp Asp Trp Met Glu Phe Ala 
            20                  25                  30          


Ser Tyr Val Ile Thr Asp Leu Thr Gln Leu Arg Lys Ile Lys Ser Met 
        35                  40                  45              


Glu Arg Val Gln Gly Val Ser Ile Thr Arg Glu Leu Leu Trp Trp Trp 
    50                  55                  60                  


Gly Met Arg Gln Ala Thr Val Gln Gln Leu Val Asp Leu Leu Cys Arg 
65                  70                  75                  80  


Leu Glu Leu Tyr Arg Ala Ala Gln Ile Ile Leu Asn Trp Lys Pro Ala 
                85                  90                  95      


Pro Glu Ile Arg Cys Pro Ile Pro Ala Phe Pro Asp Ser Val Lys Pro 
            100                 105                 110         


Glu Lys Pro Leu Ala Ala Ser Val Arg Lys Ala Glu Asp Glu Gln Glu 
        115                 120                 125             


Glu Gly Gln Pro Val Arg Met Ala Thr Phe Pro Gly Pro Gly Ser Ser 
    130                 135                 140                 


Pro Ala Arg Ala His Gln Pro Ala Phe Leu Gln Pro Pro Glu Glu Asp 
145                 150                 155                 160 


Ala Pro His Ser Leu Arg Ser Asp Leu Pro Thr Ser Ser Asp Ser Lys 
                165                 170                 175     


Asp Phe Ser Thr Ser Ile Pro Lys Gln Glu Lys Leu Leu Ser Leu Ala 
            180                 185                 190         


Gly Asp Ser Leu Phe Trp Ser Glu Ala Asp Val Val Gln Ala Thr Asp 
        195                 200                 205             


Asp Phe Asn Gln Asn Arg Lys Ile Ser Gln Gly Thr Phe Ala Asp Val 
    210                 215                 220                 


Tyr Arg Gly His Arg His Gly Lys Pro Phe Val Phe Lys Lys Leu Arg 
225                 230                 235                 240 


Glu Thr Ala Cys Ser Ser Pro Gly Ser Ile Glu Arg Phe Phe Gln Ala 
                245                 250                 255     


Glu Leu Gln Ile Cys Leu Arg Cys Cys His Pro Asn Val Leu Pro Val 
            260                 265                 270         


Leu Gly Phe Cys Ala Ala Arg Gln Phe His Ser Phe Ile Tyr Pro Tyr 
        275                 280                 285             


Met Ala Asn Gly Ser Leu Gln Asp Arg Leu Gln Gly Gln Gly Gly Ser 
    290                 295                 300                 


Asp Pro Leu Pro Trp Pro Gln Arg Val Ser Ile Cys Ser Gly Leu Leu 
305                 310                 315                 320 


Cys Ala Val Glu Tyr Leu His Gly Leu Glu Ile Ile His Ser Asn Val 
                325                 330                 335     


Lys Ser Ser Asn Val Leu Leu Asp Gln Asn Leu Thr Pro Lys Leu Ala 
            340                 345                 350         


His Pro Met Ala His Leu Cys Pro Val Asn Lys Arg Ser Lys Tyr Thr 
        355                 360                 365             


Met Met Lys Thr His Leu Leu Arg Thr Ser Ala Ala Tyr Leu Pro Glu 
    370                 375                 380                 


Asp Phe Ile Arg Val Gly Gln Leu Thr Lys Arg Val Asp Ile Phe Ser 
385                 390                 395                 400 


Cys Gly Ile Val Leu Ala Glu Val Leu Thr Gly Ile Pro Ala Met Asp 
                405                 410                 415     


Asn Asn Arg Ser Pro Val Tyr Leu Lys Asp Leu Leu Leu Ser Asp Ile 
            420                 425                 430         


Pro Ser Ser Thr Ala Ser Leu Cys Ser Arg Lys Thr Gly Val Glu Asn 
        435                 440                 445             


Val Met Ala Lys Glu Ile Cys Gln Lys Tyr Leu Glu Lys Gly Ala Gly 
    450                 455                 460                 


Arg Leu Pro Glu Asp Cys Ala Glu Ala Leu Ala Thr Ala Ala Cys Leu 
465                 470                 475                 480 


Cys Leu Arg Arg Arg Asn Thr Ser Leu Gln Glu Val Cys Gly Ser Val 
                485                 490                 495     


Ala Ala Val Glu Glu Arg Leu Arg Gly Arg Glu Thr Leu Leu Pro Trp 
            500                 505                 510         


Ser Gly Leu Ser Glu Gly Thr Gly Ser Ser Ser Asn Thr Pro Glu Glu 
        515                 520                 525             


Thr Asp Asp Val Asp Asn Ser Ser Leu Asp Ala Ser Ser Ser Met Ser 
    530                 535                 540                 


Val Ala Pro Trp Ala Gly Ala Ala Thr Pro Leu Leu Pro Thr Glu Asn 
545                 550                 555                 560 


Gly Glu Gly Arg Leu Arg Val Ile Val Gly Arg Glu Ala Asp Ser Ser 
                565                 570                 575     


Ser Glu Ala Cys Val Gly Leu Glu Pro Pro Gln Asp Val Thr Glu Thr 
            580                 585                 590         


Ser Trp Gln Ile Glu Ile Asn Glu Ala Lys Arg Lys Leu Met Glu Asn 
        595                 600                 605             


Ile Leu Leu Tyr Lys Glu Glu Lys Val Asp Ser Ile Glu Leu Phe Gly 
    610                 615                 620                 


Pro 
625 


<210>  174
<211>  420
<212>  PRT
<213>  homo sapiens

<400>  174

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  175
<211>  918
<212>  PRT
<213>  homo sapiens

<400>  175

Met Leu Thr Leu Gln Thr Trp Val Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  176
<211>  1065
<212>  PRT
<213>  homo sapiens

<400>  176

Met Asn Lys Ser Glu Asn Leu Leu Phe Ala Gly Ser Ser Leu Ala Ser 
1               5                   10                  15      


Gln Val His Ala Ala Ala Val Asn Gly Asp Lys Gly Ala Leu Gln Arg 
            20                  25                  30          


Leu Ile Val Gly Asn Ser Ala Leu Lys Asp Lys Glu Asp Gln Phe Gly 
        35                  40                  45              


Arg Thr Pro Leu Met Tyr Cys Val Leu Ala Asp Arg Leu Asp Cys Ala 
    50                  55                  60                  


Asp Ala Leu Leu Lys Ala Gly Ala Asp Val Asn Lys Thr Asp His Ser 
65                  70                  75                  80  


Gln Arg Thr Ala Leu His Leu Ala Ala Gln Lys Gly Asn Tyr Arg Phe 
                85                  90                  95      


Met Lys Leu Leu Leu Thr Arg Arg Ala Asn Trp Met Gln Lys Asp Leu 
            100                 105                 110         


Glu Glu Met Thr Pro Leu His Leu Thr Thr Arg His Arg Ser Pro Lys 
        115                 120                 125             


Cys Leu Ala Leu Leu Leu Lys Phe Met Ala Pro Gly Glu Val Asp Thr 
    130                 135                 140                 


Gln Asp Lys Asn Lys Gln Thr Ala Leu His Trp Ser Ala Tyr Tyr Asn 
145                 150                 155                 160 


Asn Pro Glu His Val Lys Leu Leu Ile Lys His Asp Ser Asn Ile Gly 
                165                 170                 175     


Ile Pro Asp Val Glu Gly Lys Ile Pro Leu His Trp Ala Ala Asn His 
            180                 185                 190         


Lys Asp Pro Ser Ala Val His Thr Val Arg Cys Ile Leu Asp Ala Ala 
        195                 200                 205             


Pro Thr Glu Ser Leu Leu Asn Trp Gln Asp Tyr Glu Gly Arg Thr Pro 
    210                 215                 220                 


Leu His Phe Ala Val Ala Asp Gly Asn Val Thr Val Val Asp Val Leu 
225                 230                 235                 240 


Thr Ser Tyr Glu Ser Cys Asn Ile Thr Ser Tyr Asp Asn Leu Phe Arg 
                245                 250                 255     


Thr Pro Leu His Trp Ala Ala Leu Leu Gly His Ala Gln Ile Val His 
            260                 265                 270         


Leu Leu Leu Glu Arg Asn Lys Ser Gly Thr Ile Pro Ser Asp Ser Gln 
        275                 280                 285             


Gly Ala Thr Pro Leu His Tyr Ala Ala Gln Ser Asn Phe Ala Glu Thr 
    290                 295                 300                 


Val Lys Val Phe Leu Lys His Pro Ser Val Lys Asp Asp Ser Asp Leu 
305                 310                 315                 320 


Glu Gly Arg Thr Ser Phe Met Trp Ala Ala Gly Lys Gly Ser Asp Asp 
                325                 330                 335     


Val Leu Arg Thr Met Leu Ser Leu Lys Ser Asp Ile Asp Ile Asn Met 
            340                 345                 350         


Ala Asp Lys Tyr Gly Gly Thr Ala Leu His Ala Ala Ala Leu Ser Gly 
        355                 360                 365             


His Val Ser Thr Val Lys Leu Leu Leu Glu Asn Asn Ala Gln Val Asp 
    370                 375                 380                 


Ala Thr Asp Val Met Lys His Thr Pro Leu Phe Arg Ala Cys Glu Met 
385                 390                 395                 400 


Gly His Lys Asp Val Ile Gln Thr Leu Ile Lys Gly Gly Ala Arg Val 
                405                 410                 415     


Asp Leu Val Asp Gln Asp Gly His Ser Leu Leu His Trp Ala Ala Leu 
            420                 425                 430         


Gly Gly Asn Ala Asp Val Cys Gln Ile Leu Ile Glu Asn Lys Ile Asn 
        435                 440                 445             


Pro Asn Val Gln Asp Tyr Ala Gly Arg Thr Pro Leu Gln Cys Ala Ala 
    450                 455                 460                 


Tyr Gly Gly Tyr Ile Asn Cys Met Ala Val Leu Met Glu Asn Asn Ala 
465                 470                 475                 480 


Asp Pro Asn Ile Gln Asp Lys Glu Gly Arg Thr Ala Leu His Trp Ser 
                485                 490                 495     


Cys Asn Asn Gly Tyr Leu Asp Ala Ile Lys Leu Leu Leu Asp Phe Ala 
            500                 505                 510         


Ala Phe Pro Asn Gln Met Glu Asn Asn Glu Glu Arg Tyr Thr Pro Leu 
        515                 520                 525             


Asp Tyr Ala Leu Leu Gly Glu Arg His Glu Val Ile Gln Phe Met Leu 
    530                 535                 540                 


Glu His Gly Ala Leu Ser Ile Ala Ala Ile Gln Asp Ile Ala Ala Phe 
545                 550                 555                 560 


Lys Ile Gln Ala Val Tyr Lys Gly Tyr Lys Val Arg Lys Ala Phe Arg 
                565                 570                 575     


Asp Arg Lys Asn Leu Leu Met Lys His Glu Gln Leu Arg Lys Asp Ala 
            580                 585                 590         


Ala Ala Lys Lys Arg Glu Glu Glu Asn Lys Arg Lys Glu Ala Glu Gln 
        595                 600                 605             


Gln Lys Gly Arg Arg Ser Pro Asp Ser Cys Arg Pro Gln Ala Leu Pro 
    610                 615                 620                 


Cys Leu Pro Ser Thr Gln Asp Val Pro Ser Arg Gln Ser Arg Ala Pro 
625                 630                 635                 640 


Ser Lys Gln Pro Pro Ala Gly Asn Val Ala Gln Gly Pro Glu Pro Arg 
                645                 650                 655     


Asp Ser Arg Gly Ser Pro Gly Gly Ser Leu Gly Gly Ala Leu Gln Lys 
            660                 665                 670         


Glu Gln His Val Ser Ser Asp Leu Gln Gly Thr Asn Ser Arg Arg Pro 
        675                 680                 685             


Asn Glu Thr Ala Arg Glu His Ser Lys Gly Gln Ser Ala Cys Val His 
    690                 695                 700                 


Phe Arg Pro Asn Glu Gly Ser Asp Gly Ser Arg His Pro Gly Val Pro 
705                 710                 715                 720 


Ser Val Glu Lys Ser Arg Gly Glu Thr Ala Gly Asp Glu Arg Cys Ala 
                725                 730                 735     


Lys Gly Lys Gly Phe Val Lys Gln Pro Ser Cys Ile Arg Val Ala Gly 
            740                 745                 750         


Pro Asp Glu Lys Gly Glu Asp Ser Arg Arg Ala Ala Ala Ser Leu Pro 
        755                 760                 765             


Pro His Asp Ser His Trp Lys Pro Ser Arg Arg His Asp Thr Glu Pro 
    770                 775                 780                 


Lys Ala Lys Cys Ala Pro Gln Lys Arg Arg Thr Gln Glu Leu Arg Gly 
785                 790                 795                 800 


Gly Arg Cys Ser Pro Ala Gly Ser Ser Arg Pro Gly Ser Ala Arg Gly 
                805                 810                 815     


Glu Ala Val His Ala Gly Gln Asn Pro Pro His His Arg Thr Pro Arg 
            820                 825                 830         


Asn Lys Val Thr Gln Ala Lys Leu Thr Gly Gly Leu Tyr Ser His Leu 
        835                 840                 845             


Pro Gln Ser Thr Glu Glu Leu Arg Ser Gly Ala Arg Arg Leu Glu Thr 
    850                 855                 860                 


Ser Thr Leu Ser Glu Asp Phe Gln Val Ser Lys Glu Thr Asp Pro Ala 
865                 870                 875                 880 


Pro Gly Pro Leu Ser Gly Gln Ser Val Asn Ile Asp Leu Leu Pro Val 
                885                 890                 895     


Glu Leu Arg Leu Gln Ile Ile Gln Arg Glu Arg Arg Arg Lys Glu Leu 
            900                 905                 910         


Phe Arg Lys Lys Asn Lys Ala Ala Ala Val Ile Gln Arg Ala Trp Arg 
        915                 920                 925             


Ser Tyr Gln Leu Arg Lys His Leu Ser His Leu Arg His Met Lys Gln 
    930                 935                 940                 


Leu Gly Ala Gly Asp Val Asp Arg Trp Arg Gln Glu Ser Thr Ala Leu 
945                 950                 955                 960 


Leu Leu Gln Val Trp Arg Lys Glu Leu Glu Leu Lys Phe Pro Gln Thr 
                965                 970                 975     


Thr Ala Val Ser Lys Ala Pro Lys Ser Pro Ser Lys Gly Thr Ser Gly 
            980                 985                 990         


Thr Lys Ser Thr Lys His Ser Val  Leu Lys Gln Ile Tyr  Gly Cys Ser 
        995                 1000                 1005             


His Glu  Gly Lys Ile His His  Pro Thr Arg Ser Val  Lys Ala Ser 
    1010                 1015                 1020             


Ser Val  Leu Arg Leu Asn Ser  Val Ser Asn Leu Gln  Cys Ile His 
    1025                 1030                 1035             


Leu Leu  Glu Asn Ser Gly Arg  Ser Lys Asn Phe Ser  Tyr Asn Leu 
    1040                 1045                 1050             


Gln Ser  Ala Thr Gln Pro Lys  Asn Lys Thr Lys Pro  
    1055                 1060                 1065 


<210>  177
<211>  442
<212>  PRT
<213>  homo sapiens

<400>  177

Met Leu Glu Trp Phe Asn Gln Gln Arg Ala Lys Gly Asn Pro Ile Ser 
1               5                   10                  15      


Gly Pro Ile Cys Ala Lys Arg Ala Glu Phe Phe Phe Tyr Ala Leu Gly 
            20                  25                  30          


Met Asp Gly Asp Phe Asn Pro Ser Ala Gly Trp Leu Thr Arg Phe Lys 
        35                  40                  45              


Gln Arg His Ser Ile Arg Glu Ile Asn Ile Arg Asn Glu Arg Leu Asn 
    50                  55                  60                  


Gly Asp Glu Thr Ala Val Glu Asp Phe Cys Asn Asn Phe Arg Asp Phe 
65                  70                  75                  80  


Ile Glu Arg Glu Asn Leu Gln Pro Glu Gln Ile Tyr Asn Ala Asp Glu 
                85                  90                  95      


Thr Gly Leu Phe Trp Lys Cys Leu Pro Ser Arg Ile Ser Val Ile Lys 
            100                 105                 110         


Gly Lys Cys Thr Val Pro Gly His Lys Ser Ile Glu Glu Arg Val Thr 
        115                 120                 125             


Ile Met Cys Cys Ala Asn Ala Thr Gly Leu His Lys Leu Lys Leu Cys 
    130                 135                 140                 


Val Val Gly Lys Ala Lys Lys Pro Arg Ser Phe Lys Ser Thr Asp Thr 
145                 150                 155                 160 


Leu Asn Leu Pro Val Ser Tyr Phe Ser Gln Lys Gly Ala Trp Met Asp 
                165                 170                 175     


Leu Ser Ile Phe Arg Gln Trp Phe Asp Lys Ile Phe Val Pro Gln Val 
            180                 185                 190         


Arg Glu Tyr Leu Arg Ser Lys Gly Leu Gln Glu Lys Ala Val Leu Leu 
        195                 200                 205             


Leu Asp Asn Ser Pro Thr His Pro Asn Glu Asn Val Leu Arg Ser Asp 
    210                 215                 220                 


Asp Gly Gln Ile Phe Ala Lys Tyr Leu Pro Pro Asn Val Ala Ser Leu 
225                 230                 235                 240 


Ile Gln Pro Ser Asp Gln Gly Val Ile Ala Thr Met Lys Arg Asn Tyr 
                245                 250                 255     


Arg Ala Gly Leu Leu Gln Asn Asn Leu Glu Glu Gly Asn Asp Leu Lys 
            260                 265                 270         


Ser Phe Trp Lys Lys Leu Thr Leu Leu Asp Ala Leu Tyr Glu Ile Ala 
        275                 280                 285             


Met Ala Trp Asn Leu Val Lys Pro Val Thr Ile Ser Arg Ala Trp Lys 
    290                 295                 300                 


Lys Ile Leu Pro Met Val Glu Glu Lys Glu Ser Leu Asp Phe Asp Val 
305                 310                 315                 320 


Glu Asp Ile Ser Val Ala Thr Val Ala Ala Ile Leu Gln His Thr Lys 
                325                 330                 335     


Gly Leu Glu Asn Val Thr Thr Glu Asn Leu Glu Lys Trp Leu Glu Val 
            340                 345                 350         


Asp Ser Thr Glu Pro Gly Tyr Glu Val Leu Thr Asp Ser Glu Ile Ile 
        355                 360                 365             


Arg Arg Ala Gln Gly Gln Ala Asp Glu Ser Ser Glu Asn Glu Glu Glu 
    370                 375                 380                 


Glu Ile Glu Leu Ile Pro Glu Lys His Ile Asn His Ala Ala Ala Leu 
385                 390                 395                 400 


Gln Trp Thr Glu Asn Leu Leu Asp Tyr Leu Glu Gln Gln Gly Asp Met 
                405                 410                 415     


Ile Leu Pro Asp Arg Leu Val Ile Arg Lys Leu Arg Ala Thr Ile Arg 
            420                 425                 430         


Asn Lys Gln Lys Met Thr Lys Ser Ser Gln 
        435                 440         


<210>  178
<211>  1246
<212>  PRT
<213>  homo sapiens

<400>  178

Met Ser Lys Glu Arg Pro Lys Arg Asn Ile Ile Gln Lys Lys Tyr Asp 
1               5                   10                  15      


Asp Ser Asp Gly Ile Pro Trp Ser Glu Glu Arg Val Val Arg Lys Val 
            20                  25                  30          


Leu Tyr Leu Ser Leu Lys Glu Phe Lys Asn Ser Gln Lys Arg Gln His 
        35                  40                  45              


Ala Glu Gly Ile Ala Gly Ser Leu Lys Thr Val Asn Gly Leu Leu Gly 
    50                  55                  60                  


Asn Asp Gln Ser Lys Gly Leu Gly Pro Ala Ser Glu Gln Ser Glu Asn 
65                  70                  75                  80  


Glu Lys Asp Asp Ala Ser Gln Val Ser Ser Thr Ser Asn Asp Val Ser 
                85                  90                  95      


Ser Ser Asp Phe Glu Glu Gly Pro Ser Arg Lys Arg Pro Arg Leu Gln 
            100                 105                 110         


Ala Gln Arg Lys Phe Ala Gln Ser Gln Pro Asn Ser Pro Ser Thr Thr 
        115                 120                 125             


Pro Val Lys Ile Val Glu Pro Leu Leu Pro Pro Pro Ala Thr Gln Ile 
    130                 135                 140                 


Ser Asp Leu Ser Lys Arg Lys Pro Lys Thr Glu Asp Phe Leu Thr Phe 
145                 150                 155                 160 


Leu Cys Leu Arg Gly Ser Pro Ala Leu Pro Asn Ser Met Val Tyr Phe 
                165                 170                 175     


Gly Ser Ser Gln Asp Glu Glu Glu Val Glu Glu Glu Asp Asp Glu Thr 
            180                 185                 190         


Glu Asp Val Lys Thr Ala Thr Asn Asn Ala Ser Ser Ser Cys Gln Ser 
        195                 200                 205             


Thr Pro Arg Lys Gly Lys Thr His Lys His Val His Asn Gly His Val 
    210                 215                 220                 


Phe Asn Gly Ser Ser Arg Ser Thr Arg Glu Lys Glu Pro Val Gln Lys 
225                 230                 235                 240 


His Lys Ser Lys Glu Ala Thr Pro Ala Lys Glu Lys His Ser Asp His 
                245                 250                 255     


Arg Ala Asp Ser Arg Arg Glu Gln Ala Ser Ala Asn His Pro Ala Ala 
            260                 265                 270         


Ala Pro Ser Thr Gly Ser Ser Ala Lys Gly Leu Ala Ala Thr His His 
        275                 280                 285             


His Pro Pro Leu His Arg Ser Ala Gln Asp Leu Arg Lys Gln Val Ser 
    290                 295                 300                 


Lys Val Asn Gly Val Thr Arg Met Ser Ser Leu Gly Ala Gly Val Thr 
305                 310                 315                 320 


Ser Ala Lys Lys Met Arg Glu Val Arg Pro Ser Pro Ser Lys Thr Val 
                325                 330                 335     


Lys Tyr Thr Ala Thr Val Thr Lys Gly Ala Val Thr Tyr Thr Lys Ala 
            340                 345                 350         


Lys Arg Glu Leu Val Lys Asp Thr Lys Pro Asn His His Lys Pro Ser 
        355                 360                 365             


Ser Ala Val Asn His Thr Ile Ser Gly Lys Thr Glu Ser Ser Asn Ala 
    370                 375                 380                 


Lys Thr Arg Lys Gln Val Leu Ser Leu Gly Gly Ala Ser Lys Ser Thr 
385                 390                 395                 400 


Gly Pro Ala Val Asn Gly Leu Lys Val Ser Gly Arg Leu Asn Pro Lys 
                405                 410                 415     


Ser Cys Thr Lys Glu Val Gly Gly Arg Gln Leu Arg Glu Gly Leu Gln 
            420                 425                 430         


Leu Arg Glu Gly Leu Arg Asn Ser Lys Arg Arg Leu Glu Glu Ala His 
        435                 440                 445             


Gln Ala Glu Lys Pro Gln Ser Pro Pro Lys Lys Met Lys Gly Ala Ala 
    450                 455                 460                 


Gly Pro Ala Glu Gly Pro Gly Lys Lys Ala Pro Ala Glu Arg Gly Leu 
465                 470                 475                 480 


Leu Asn Gly His Val Lys Lys Glu Val Pro Glu Arg Ser Leu Glu Arg 
                485                 490                 495     


Asn Arg Pro Lys Arg Ala Thr Ala Gly Lys Ser Thr Pro Gly Arg Gln 
            500                 505                 510         


Ala His Gly Lys Ala Asp Ser Ala Ser Cys Glu Asn Arg Ser Thr Ser 
        515                 520                 525             


Gln Pro Glu Ser Val His Lys Pro Gln Asp Ser Gly Lys Ala Glu Lys 
    530                 535                 540                 


Gly Gly Gly Lys Ala Gly Trp Ala Ala Met Asp Glu Ile Pro Val Leu 
545                 550                 555                 560 


Arg Pro Ser Ala Lys Glu Phe His Asp Pro Leu Ile Tyr Ile Glu Ser 
                565                 570                 575     


Val Arg Ala Gln Val Glu Lys Phe Gly Met Cys Arg Val Ile Pro Pro 
            580                 585                 590         


Pro Asp Trp Arg Pro Glu Cys Lys Leu Asn Asp Glu Met Arg Phe Val 
        595                 600                 605             


Thr Gln Ile Gln His Ile His Lys Leu Gly Arg Arg Trp Gly Pro Asn 
    610                 615                 620                 


Val Gln Arg Leu Ala Cys Ile Lys Lys His Leu Lys Ser Gln Gly Ile 
625                 630                 635                 640 


Thr Met Asp Glu Leu Pro Leu Ile Gly Gly Cys Glu Leu Asp Leu Ala 
                645                 650                 655     


Cys Phe Phe Arg Leu Ile Asn Glu Met Gly Gly Met Gln Gln Val Thr 
            660                 665                 670         


Asp Leu Lys Lys Trp Asn Lys Leu Ala Asp Met Leu Arg Ile Pro Arg 
        675                 680                 685             


Thr Ala Gln Asp Arg Leu Ala Lys Leu Gln Glu Ala Tyr Cys Gln Tyr 
    690                 695                 700                 


Leu Leu Ser Tyr Asp Ser Leu Ser Pro Glu Glu His Arg Arg Leu Glu 
705                 710                 715                 720 


Lys Glu Val Leu Met Glu Lys Glu Ile Leu Glu Lys Arg Lys Gly Pro 
                725                 730                 735     


Leu Glu Gly His Thr Glu Asn Asp His His Lys Phe His Pro Leu Pro 
            740                 745                 750         


Arg Phe Glu Pro Lys Asn Gly Leu Ile His Gly Val Ala Pro Arg Asn 
        755                 760                 765             


Gly Phe Arg Ser Lys Leu Lys Glu Val Gly Gln Ala Gln Leu Lys Thr 
    770                 775                 780                 


Gly Arg Arg Arg Leu Phe Ala Gln Glu Lys Glu Val Val Lys Glu Glu 
785                 790                 795                 800 


Glu Glu Asp Lys Gly Val Leu Asn Asp Phe His Lys Cys Ile Tyr Lys 
                805                 810                 815     


Gly Arg Ser Val Ser Leu Thr Thr Phe Tyr Arg Thr Ala Arg Asn Ile 
            820                 825                 830         


Met Ser Met Cys Phe Ser Lys Glu Pro Ala Pro Ala Glu Ile Glu Gln 
        835                 840                 845             


Glu Tyr Trp Arg Leu Val Glu Glu Lys Asp Cys His Val Ala Val His 
    850                 855                 860                 


Cys Gly Lys Val Asp Thr Asn Thr His Gly Ser Gly Phe Pro Val Gly 
865                 870                 875                 880 


Lys Ser Glu Pro Phe Ser Arg His Gly Trp Asn Leu Thr Val Leu Pro 
                885                 890                 895     


Asn Asn Thr Gly Ser Ile Leu Arg His Leu Gly Ala Val Pro Gly Val 
            900                 905                 910         


Thr Ile Pro Trp Leu Asn Ile Gly Met Val Phe Ser Thr Ser Cys Trp 
        915                 920                 925             


Ser Arg Asp Gln Asn His Leu Pro Tyr Ile Asp Tyr Leu His Thr Gly 
    930                 935                 940                 


Ala Asp Cys Ile Trp Tyr Cys Ile Pro Ala Glu Glu Glu Asn Lys Leu 
945                 950                 955                 960 


Glu Asp Val Val His Thr Leu Leu Gln Ala Asn Gly Thr Pro Gly Leu 
                965                 970                 975     


Gln Met Leu Glu Ser Asn Val Met Ile Ser Pro Glu Val Leu Cys Lys 
            980                 985                 990         


Glu Gly Ile Lys Val His Arg Thr  Val Gln Gln Ser Gly  Gln Phe Val 
        995                 1000                 1005             


Val Cys  Phe Pro Gly Ser Phe  Val Ser Lys Val Cys  Cys Gly Tyr 
    1010                 1015                 1020             


Ser Val  Ser Glu Thr Val His  Phe Ala Thr Thr Gln  Trp Thr Ser 
    1025                 1030                 1035             


Met Gly  Phe Glu Thr Ala Lys  Glu Met Lys Arg Arg  His Ile Ala 
    1040                 1045                 1050             


Lys Pro  Phe Ser Met Glu Lys  Leu Leu Tyr Gln Ile  Ala Gln Ala 
    1055                 1060                 1065             


Glu Ala  Lys Lys Glu Asn Gly  Pro Thr Leu Ser Thr  Ile Ser Ala 
    1070                 1075                 1080             


Leu Leu  Asp Glu Leu Arg Asp  Thr Glu Leu Arg Gln  Arg Arg Gln 
    1085                 1090                 1095             


Leu Phe  Glu Ala Gly Leu His  Ser Ser Ala Arg Tyr  Gly Ser His 
    1100                 1105                 1110             


Asp Gly  Ser Ser Thr Val Ala  Asp Gly Lys Lys Lys  Pro Arg Lys 
    1115                 1120                 1125             


Trp Leu  Gln Leu Glu Thr Ser  Glu Arg Arg Cys Gln  Ile Cys Gln 
    1130                 1135                 1140             


His Leu  Cys Tyr Leu Ser Met  Val Val Gln Glu Asn  Glu Asn Val 
    1145                 1150                 1155             


Val Phe  Cys Leu Glu Cys Ala  Leu Arg His Val Glu  Lys Gln Lys 
    1160                 1165                 1170             


Ser Cys  Arg Gly Leu Lys Leu  Met Tyr Arg Tyr Asp  Glu Glu Gln 
    1175                 1180                 1185             


Ile Ile  Ser Leu Val Asn Gln  Ile Cys Gly Lys Val  Ser Gly Lys 
    1190                 1195                 1200             


Asn Gly  Ser Ile Glu Asn Cys  Leu Ser Lys Pro Thr  Pro Lys Arg 
    1205                 1210                 1215             


Gly Pro  Arg Lys Arg Ala Thr  Val Asp Val Pro Pro  Ser Arg Leu 
    1220                 1225                 1230             


Ser Ala  Ser Ser Ser Ser Lys  Ser Ala Ser Ser Ser  Ser 
    1235                 1240                 1245     


<210>  179
<211>  615
<212>  PRT
<213>  homo sapiens

<400>  179

Met Pro Ser Arg Lys Phe Ala Asp Gly Glu Val Val Arg Gly Arg Trp 
1               5                   10                  15      


Pro Gly Ser Ser Leu Tyr Tyr Glu Val Glu Ile Leu Ser His Asp Ser 
            20                  25                  30          


Thr Ser Gln Leu Tyr Thr Val Lys Tyr Lys Asp Gly Thr Glu Leu Glu 
        35                  40                  45              


Leu Lys Glu Asn Asp Ile Lys Pro Leu Thr Ser Phe Arg Gln Arg Lys 
    50                  55                  60                  


Gly Gly Ser Thr Ser Ser Ser Pro Ser Arg Arg Arg Gly Ser Arg Ser 
65                  70                  75                  80  


Arg Ser Arg Ser Arg Ser Pro Gly Arg Pro Pro Lys Ser Ala Arg Arg 
                85                  90                  95      


Ser Ala Ser Ala Ser His Gln Ala Asp Ile Lys Glu Ala Arg Arg Glu 
            100                 105                 110         


Val Glu Val Lys Leu Thr Pro Leu Ile Leu Lys Pro Phe Gly Asn Ser 
        115                 120                 125             


Ile Ser Arg Tyr Asn Gly Glu Pro Glu His Ile Glu Arg Asn Asp Ala 
    130                 135                 140                 


Pro His Lys Asn Thr Gln Glu Lys Phe Ser Leu Ser Gln Glu Ser Ser 
145                 150                 155                 160 


Tyr Ile Ala Thr Gln Tyr Ser Leu Arg Pro Arg Arg Glu Glu Val Lys 
                165                 170                 175     


Leu Lys Glu Ile Asp Ser Lys Glu Glu Lys Tyr Val Ala Lys Glu Leu 
            180                 185                 190         


Ala Val Arg Thr Phe Glu Val Thr Pro Ile Arg Ala Lys Asp Leu Glu 
        195                 200                 205             


Phe Gly Gly Val Pro Gly Val Phe Leu Ile Met Phe Gly Leu Pro Val 
    210                 215                 220                 


Phe Leu Phe Leu Leu Leu Leu Met Cys Lys Gln Lys Asp Pro Ser Leu 
225                 230                 235                 240 


Leu Asn Phe Pro Pro Pro Leu Pro Ala Leu Tyr Glu Leu Trp Glu Thr 
                245                 250                 255     


Arg Val Phe Gly Val Tyr Leu Leu Trp Phe Leu Ile Gln Val Leu Phe 
            260                 265                 270         


Tyr Leu Leu Pro Ile Gly Lys Val Val Glu Gly Thr Pro Leu Ile Asp 
        275                 280                 285             


Gly Arg Arg Leu Lys Tyr Arg Leu Asn Gly Phe Tyr Ala Phe Ile Leu 
    290                 295                 300                 


Thr Ser Ala Val Ile Gly Thr Ser Leu Phe Gln Gly Val Glu Phe His 
305                 310                 315                 320 


Tyr Val Tyr Ser His Phe Leu Gln Phe Ala Leu Ala Ala Thr Val Phe 
                325                 330                 335     


Cys Val Val Leu Ser Val Tyr Leu Tyr Met Arg Ser Leu Lys Ala Pro 
            340                 345                 350         


Arg Asn Asp Leu Ser Pro Ala Ser Ser Gly Asn Ala Val Tyr Asp Phe 
        355                 360                 365             


Phe Ile Gly Arg Glu Leu Asn Pro Arg Ile Gly Thr Phe Asp Leu Lys 
    370                 375                 380                 


Tyr Phe Cys Glu Leu Arg Pro Gly Leu Ile Gly Trp Val Val Ile Asn 
385                 390                 395                 400 


Leu Val Met Leu Leu Ala Glu Met Lys Ile Gln Asp Arg Ala Val Pro 
                405                 410                 415     


Ser Leu Ala Met Ile Leu Val Asn Ser Phe Gln Leu Leu Tyr Val Val 
            420                 425                 430         


Asp Ala Leu Trp Asn Glu Glu Ala Leu Leu Thr Thr Met Asp Ile Ile 
        435                 440                 445             


His Asp Gly Phe Gly Phe Met Leu Ala Phe Gly Asp Leu Val Trp Val 
    450                 455                 460                 


Pro Phe Ile Tyr Ser Phe Gln Ala Phe Tyr Leu Val Ser His Pro Asn 
465                 470                 475                 480 


Glu Val Ser Trp Pro Met Ala Ser Leu Ile Ile Val Leu Lys Leu Cys 
                485                 490                 495     


Gly Tyr Val Ile Phe Arg Gly Ala Asn Ser Gln Lys Asn Ala Phe Arg 
            500                 505                 510         


Lys Asn Pro Ser Asp Pro Lys Leu Ala His Leu Lys Thr Ile His Thr 
        515                 520                 525             


Ser Thr Gly Lys Asn Leu Leu Val Ser Gly Trp Trp Gly Phe Val Arg 
    530                 535                 540                 


His Pro Asn Tyr Leu Gly Asp Leu Ile Met Ala Leu Ala Trp Ser Leu 
545                 550                 555                 560 


Pro Cys Gly Phe Asn His Ile Leu Pro Tyr Phe Tyr Ile Ile Tyr Phe 
                565                 570                 575     


Thr Met Leu Leu Val His Arg Glu Ala Arg Asp Glu Tyr His Cys Lys 
            580                 585                 590         


Lys Lys Tyr Gly Val Ala Trp Glu Lys Tyr Cys Gln Arg Val Pro Tyr 
        595                 600                 605             


Arg Ile Phe Pro Tyr Ile Tyr 
    610                 615 


<210>  180
<211>  1609
<212>  PRT
<213>  homo sapiens

<400>  180

Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln 
        35                  40                  45              


Arg Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val 
    50                  55                  60                  


Ala Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr 
65                  70                  75                  80  


Gly Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln 
                85                  90                  95      


Pro His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln 
            100                 105                 110         


Ala Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln 
        115                 120                 125             


Tyr Pro Ser Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp 
    130                 135                 140                 


Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe 
145                 150                 155                 160 


Ala Ile Tyr Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly 
            180                 185                 190         


Phe Ile Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu 
        195                 200                 205             


Phe Ser Asp Phe Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr 
    210                 215                 220                 


Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu 
225                 230                 235                 240 


Gln Glu Trp Val Thr Ala Thr Asp Ile Arg Val Thr Leu Asn Arg Leu 
                245                 250                 255     


Asn Thr Phe Gly Asp Glu Val Phe Asn Asp Pro Lys Val Leu Lys Ser 
            260                 265                 270         


Tyr Tyr Tyr Ala Ile Ser Asp Phe Ala Val Gly Gly Arg Cys Lys Cys 
        275                 280                 285             


Asn Gly His Ala Ser Glu Cys Met Lys Asn Glu Phe Asp Lys Leu Val 
    290                 295                 300                 


Cys Asn Cys Lys His Asn Thr Tyr Gly Val Asp Cys Glu Lys Cys Leu 
305                 310                 315                 320 


Pro Phe Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr Ala Glu Ser Ala 
                325                 330                 335     


Ser Glu Cys Leu Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr 
            340                 345                 350         


Phe Asp Pro Glu Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr 
        355                 360                 365             


Asn Cys Gln Asp Asn Thr Asp Gly Ala His Cys Glu Arg Cys Arg Glu 
    370                 375                 380                 


Asn Phe Phe Arg Leu Gly Asn Asn Glu Ala Cys Ser Ser Cys His Cys 
385                 390                 395                 400 


Ser Pro Val Gly Ser Leu Ser Thr Gln Cys Asp Ser Tyr Gly Arg Cys 
                405                 410                 415     


Ser Cys Lys Pro Gly Val Met Gly Asp Lys Cys Asp Arg Cys Gln Pro 
            420                 425                 430         


Gly Phe His Ser Leu Thr Glu Ala Gly Cys Arg Pro Cys Ser Cys Asp 
        435                 440                 445             


Pro Ser Gly Ser Ile Asp Glu Cys Asn Val Glu Thr Gly Arg Cys Val 
    450                 455                 460                 


Cys Lys Asp Asn Val Glu Gly Phe Asn Cys Glu Arg Cys Lys Pro Gly 
465                 470                 475                 480 


Phe Phe Asn Leu Glu Ser Ser Asn Pro Arg Gly Cys Thr Pro Cys Phe 
                485                 490                 495     


Cys Phe Gly His Ser Ser Val Cys Thr Asn Ala Val Gly Tyr Ser Val 
            500                 505                 510         


Tyr Ser Ile Ser Ser Thr Phe Gln Ile Asp Glu Asp Gly Trp Arg Ala 
        515                 520                 525             


Glu Gln Arg Asp Gly Ser Glu Ala Ser Leu Glu Trp Ser Ser Glu Arg 
    530                 535                 540                 


Gln Asp Ile Ala Val Ile Ser Asp Ser Tyr Phe Pro Arg Tyr Phe Ile 
545                 550                 555                 560 


Ala Pro Ala Lys Phe Leu Gly Lys Gln Val Leu Ser Tyr Gly Gln Asn 
                565                 570                 575     


Leu Ser Phe Ser Phe Arg Val Asp Arg Arg Asp Thr Arg Leu Ser Ala 
            580                 585                 590         


Glu Asp Leu Val Leu Glu Gly Ala Gly Leu Arg Val Ser Val Pro Leu 
        595                 600                 605             


Ile Ala Gln Gly Asn Ser Tyr Pro Ser Glu Thr Thr Val Lys Tyr Val 
    610                 615                 620                 


Phe Arg Leu His Glu Ala Thr Asp Tyr Pro Trp Arg Pro Ala Leu Thr 
625                 630                 635                 640 


Pro Phe Glu Phe Gln Lys Leu Leu Asn Asn Leu Thr Ser Ile Lys Ile 
                645                 650                 655     


Arg Gly Thr Tyr Ser Glu Arg Ser Ala Gly Tyr Leu Asp Asp Val Thr 
            660                 665                 670         


Leu Ala Ser Ala Arg Pro Gly Pro Gly Val Pro Ala Thr Trp Val Glu 
        675                 680                 685             


Ser Cys Thr Cys Pro Val Gly Tyr Gly Gly Gln Phe Cys Glu Met Cys 
    690                 695                 700                 


Leu Ser Gly Tyr Arg Arg Glu Thr Pro Asn Leu Gly Pro Tyr Ser Pro 
705                 710                 715                 720 


Cys Val Leu Cys Ala Cys Asn Gly His Ser Glu Thr Cys Asp Pro Glu 
                725                 730                 735     


Thr Gly Val Cys Asn Cys Arg Asp Asn Thr Ala Gly Pro His Cys Glu 
            740                 745                 750         


Lys Cys Ser Asp Gly Tyr Tyr Gly Asp Ser Thr Ala Gly Thr Ser Ser 
        755                 760                 765             


Asp Cys Gln Pro Cys Pro Cys Pro Gly Gly Ser Ser Cys Ala Val Val 
    770                 775                 780                 


Pro Lys Thr Lys Glu Val Val Cys Thr Asn Cys Pro Thr Gly Thr Thr 
785                 790                 795                 800 


Gly Lys Arg Cys Glu Leu Cys Asp Asp Gly Tyr Phe Gly Asp Pro Leu 
                805                 810                 815     


Gly Arg Asn Gly Pro Val Arg Leu Cys Arg Leu Cys Gln Cys Ser Asp 
            820                 825                 830         


Asn Ile Asp Pro Asn Ala Val Gly Asn Cys Asn Arg Leu Thr Gly Glu 
        835                 840                 845             


Cys Leu Lys Cys Ile Tyr Asn Thr Ala Gly Phe Tyr Cys Asp Arg Cys 
    850                 855                 860                 


Lys Asp Gly Phe Phe Gly Asn Pro Leu Ala Pro Asn Pro Ala Asp Lys 
865                 870                 875                 880 


Cys Lys Ala Cys Asn Cys Asn Pro Tyr Gly Thr Met Lys Gln Gln Ser 
                885                 890                 895     


Ser Cys Asn Pro Val Thr Gly Gln Cys Glu Cys Leu Pro His Val Thr 
            900                 905                 910         


Gly Gln Asp Cys Gly Ala Cys Asp Pro Gly Phe Tyr Asn Leu Gln Ser 
        915                 920                 925             


Gly Gln Gly Cys Glu Arg Cys Asp Cys His Ala Leu Gly Ser Thr Asn 
    930                 935                 940                 


Gly Gln Cys Asp Ile Arg Thr Gly Gln Cys Glu Cys Gln Pro Gly Ile 
945                 950                 955                 960 


Thr Gly Gln His Cys Glu Arg Cys Glu Val Asn His Phe Gly Phe Gly 
                965                 970                 975     


Pro Glu Gly Cys Lys Pro Cys Asp Cys His Pro Glu Gly Ser Leu Ser 
            980                 985                 990         


Leu Gln Cys Lys Asp Asp Gly Arg  Cys Glu Cys Arg Glu  Gly Phe Val 
        995                 1000                 1005             


Gly Asn  Arg Cys Asp Gln Cys  Glu Glu Asn Tyr Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Ser Trp  Pro Gly Cys Gln Glu  Cys Pro Ala Cys Tyr  Arg Leu Val 
    1025                 1030                 1035             


Lys Asp  Lys Val Ala Asp His  Arg Val Lys Leu Gln  Glu Leu Glu 
    1040                 1045                 1050             


Ser Leu  Ile Ala Asn Leu Gly  Thr Gly Asp Glu Met  Val Thr Asp 
    1055                 1060                 1065             


Gln Ala  Phe Glu Asp Arg Leu  Lys Glu Ala Glu Arg  Glu Val Met 
    1070                 1075                 1080             


Asp Leu  Leu Arg Glu Ala Gln  Asp Val Lys Asp Val  Asp Gln Asn 
    1085                 1090                 1095             


Leu Met  Asp Arg Leu Gln Arg  Val Asn Asn Thr Leu  Ser Ser Gln 
    1100                 1105                 1110             


Ile Ser  Arg Leu Gln Asn Ile  Arg Asn Thr Ile Glu  Glu Thr Gly 
    1115                 1120                 1125             


Asn Leu  Ala Glu Gln Ala Arg  Ala His Val Glu Asn  Thr Glu Arg 
    1130                 1135                 1140             


Leu Ile  Glu Ile Ala Ser Arg  Glu Leu Glu Lys Ala  Lys Val Ala 
    1145                 1150                 1155             


Ala Ala  Asn Val Ser Val Thr  Gln Pro Glu Ser Thr  Gly Asp Pro 
    1160                 1165                 1170             


Asn Asn  Met Thr Leu Leu Ala  Glu Glu Ala Arg Lys  Leu Ala Glu 
    1175                 1180                 1185             


Arg His  Lys Gln Glu Ala Asp  Asp Ile Val Arg Val  Ala Lys Thr 
    1190                 1195                 1200             


Ala Asn  Asp Thr Ser Thr Glu  Ala Tyr Asn Leu Leu  Leu Arg Thr 
    1205                 1210                 1215             


Leu Ala  Gly Glu Asn Gln Thr  Ala Phe Glu Ile Glu  Glu Leu Asn 
    1220                 1225                 1230             


Arg Lys  Tyr Glu Gln Ala Lys  Asn Ile Ser Gln Asp  Leu Glu Lys 
    1235                 1240                 1245             


Gln Ala  Ala Arg Val His Glu  Glu Ala Lys Arg Ala  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Glu Ile Tyr Ala Ser  Val Ala Gln Leu Ser  Pro Leu Asp 
    1265                 1270                 1275             


Ser Glu  Thr Leu Glu Asn Glu  Ala Asn Asn Ile Lys  Met Glu Ala 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gln Leu Ile  Asp Gln Lys Leu Lys  Asp Tyr Glu 
    1295                 1300                 1305             


Asp Leu  Arg Glu Asp Met Arg  Gly Lys Glu Leu Glu  Val Lys Asn 
    1310                 1315                 1320             


Leu Leu  Glu Lys Gly Lys Thr  Glu Gln Gln Thr Ala  Asp Gln Leu 
    1325                 1330                 1335             


Leu Ala  Arg Ala Asp Ala Ala  Lys Ala Leu Ala Glu  Glu Ala Ala 
    1340                 1345                 1350             


Lys Lys  Gly Arg Asp Thr Leu  Gln Glu Ala Asn Asp  Ile Leu Asn 
    1355                 1360                 1365             


Asn Leu  Lys Asp Phe Asp Arg  Arg Val Asn Asp Asn  Lys Thr Ala 
    1370                 1375                 1380             


Ala Glu  Glu Ala Leu Arg Lys  Ile Pro Ala Ile Asn  Gln Thr Ile 
    1385                 1390                 1395             


Thr Glu  Ala Asn Glu Lys Thr  Arg Glu Ala Gln Gln  Ala Leu Gly 
    1400                 1405                 1410             


Ser Ala  Ala Ala Asp Ala Thr  Glu Ala Lys Asn Lys  Ala His Glu 
    1415                 1420                 1425             


Ala Glu  Arg Ile Ala Ser Ala  Val Gln Lys Asn Ala  Thr Ser Thr 
    1430                 1435                 1440             


Lys Ala  Glu Ala Glu Arg Thr  Phe Ala Glu Val Thr  Asp Leu Asp 
    1445                 1450                 1455             


Asn Glu  Val Asn Asn Met Leu  Lys Gln Leu Gln Glu  Ala Glu Lys 
    1460                 1465                 1470             


Glu Leu  Lys Arg Lys Gln Asp  Asp Ala Asp Gln Asp  Met Met Met 
    1475                 1480                 1485             


Ala Gly  Met Ala Ser Gln Ala  Ala Gln Glu Ala Glu  Ile Asn Ala 
    1490                 1495                 1500             


Arg Lys  Ala Lys Asn Ser Val  Thr Ser Leu Leu Ser  Ile Ile Asn 
    1505                 1510                 1515             


Asp Leu  Leu Glu Gln Leu Gly  Gln Leu Asp Thr Val  Asp Leu Asn 
    1520                 1525                 1530             


Lys Leu  Asn Glu Ile Glu Gly  Thr Leu Asn Lys Ala  Lys Asp Glu 
    1535                 1540                 1545             


Met Lys  Val Ser Asp Leu Asp  Arg Lys Val Ser Asp  Leu Glu Asn 
    1550                 1555                 1560             


Glu Ala  Lys Lys Gln Glu Ala  Ala Ile Met Asp Tyr  Asn Arg Asp 
    1565                 1570                 1575             


Ile Glu  Glu Ile Met Lys Asp  Ile Arg Asn Leu Glu  Asp Ile Arg 
    1580                 1585                 1590             


Lys Thr  Leu Pro Ser Gly Cys  Phe Asn Thr Pro Ser  Ile Glu Lys 
    1595                 1600                 1605             


Pro 
    


<210>  181
<211>  513
<212>  PRT
<213>  homo sapiens

<400>  181

Met Lys Arg Leu Leu Leu Leu Phe Leu Phe Phe Ile Thr Phe Ser Ser 
1               5                   10                  15      


Ala Phe Pro Leu Val Arg Met Met Glu Asn Glu Glu Asn Val Gln Leu 
            20                  25                  30          


Ala Gln Ala Tyr Leu Asn Gln Phe Tyr Ser Leu Glu Ile Glu Gly Asn 
        35                  40                  45              


His Leu Val Gln Ser Lys Asn Arg Ser Leu Ile Asp Asp Lys Ile Arg 
    50                  55                  60                  


Glu Met Gln Ala Phe Phe Gly Leu Thr Val Thr Gly Lys Leu Asp Ser 
65                  70                  75                  80  


Asn Thr Leu Glu Ile Met Lys Thr Pro Arg Cys Gly Val Pro Asp Val 
                85                  90                  95      


Gly Gln Tyr Gly Tyr Thr Leu Pro Gly Trp Arg Lys Tyr Asn Leu Thr 
            100                 105                 110         


Tyr Arg Ile Ile Asn Tyr Thr Pro Asp Met Ala Arg Ala Ala Val Asp 
        115                 120                 125             


Glu Ala Ile Gln Glu Gly Leu Glu Val Trp Ser Lys Val Thr Pro Leu 
    130                 135                 140                 


Lys Phe Thr Lys Ile Ser Lys Gly Ile Ala Asp Ile Met Ile Ala Phe 
145                 150                 155                 160 


Arg Thr Arg Val His Gly Arg Cys Pro Arg Tyr Phe Asp Gly Pro Leu 
                165                 170                 175     


Gly Val Leu Gly His Ala Phe Pro Pro Gly Pro Gly Leu Gly Gly Asp 
            180                 185                 190         


Thr His Phe Asp Glu Asp Glu Asn Trp Thr Lys Asp Gly Ala Gly Phe 
        195                 200                 205             


Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu 
    210                 215                 220                 


Ser His Ser Asn Asp Gln Thr Ala Leu Met Phe Pro Asn Tyr Val Ser 
225                 230                 235                 240 


Leu Asp Pro Arg Lys Tyr Pro Leu Ser Gln Asp Asp Ile Asn Gly Ile 
                245                 250                 255     


Gln Ser Ile Tyr Gly Gly Leu Pro Lys Glu Pro Ala Lys Pro Lys Glu 
            260                 265                 270         


Pro Thr Ile Pro His Ala Cys Asp Pro Asp Leu Thr Phe Asp Ala Ile 
        275                 280                 285             


Thr Thr Phe Arg Arg Glu Val Met Phe Phe Lys Gly Arg His Leu Trp 
    290                 295                 300                 


Arg Ile Tyr Tyr Asp Ile Thr Asp Val Glu Phe Glu Leu Ile Ala Ser 
305                 310                 315                 320 


Phe Trp Pro Ser Leu Pro Ala Asp Leu Gln Ala Ala Tyr Glu Asn Pro 
                325                 330                 335     


Arg Asp Lys Ile Leu Val Phe Lys Asp Glu Asn Phe Trp Met Ile Arg 
            340                 345                 350         


Gly Tyr Ala Val Leu Pro Asp Tyr Pro Lys Ser Ile His Thr Leu Gly 
        355                 360                 365             


Phe Pro Gly Arg Val Lys Lys Ile Asp Ala Ala Val Cys Asp Lys Thr 
    370                 375                 380                 


Thr Arg Lys Thr Tyr Phe Phe Val Gly Ile Trp Cys Trp Arg Phe Asp 
385                 390                 395                 400 


Glu Met Thr Gln Thr Met Asp Lys Gly Phe Pro Gln Arg Val Val Lys 
                405                 410                 415     


His Phe Pro Gly Ile Ser Ile Arg Val Asp Ala Ala Phe Gln Tyr Lys 
            420                 425                 430         


Gly Phe Phe Phe Phe Ser Arg Gly Ser Lys Gln Phe Glu Tyr Asp Ile 
        435                 440                 445             


Lys Thr Lys Asn Ile Thr Arg Ile Met Arg Thr Asn Thr Trp Phe Gln 
    450                 455                 460                 


Cys Lys Glu Pro Lys Asn Ser Ser Phe Gly Phe Asp Ile Asn Lys Glu 
465                 470                 475                 480 


Lys Ala His Ser Gly Gly Ile Lys Ile Leu Tyr His Lys Ser Leu Ser 
                485                 490                 495     


Leu Phe Ile Phe Gly Ile Val His Leu Leu Lys Asn Thr Ser Ile Tyr 
            500                 505                 510         


Gln 
    


<210>  182
<211>  326
<212>  PRT
<213>  homo sapiens

<400>  182

Met Phe Gly Ala Ala Ala Arg Ser Ala Asp Leu Ala Leu Leu Glu Lys 
1               5                   10                  15      


Asn Leu Gln Ala Ala His Gly Cys Leu Gly Leu Tyr Cys Gly Lys Thr 
            20                  25                  30          


Leu Leu Phe Lys Asn Gly Ser Thr Glu Ile Tyr Gly Glu Cys Gly Val 
        35                  40                  45              


Cys Pro Arg Gly Gln Arg Thr Asn Ala Gln Lys Tyr Cys Gln Pro Cys 
    50                  55                  60                  


Thr Glu Ser Pro Glu Leu Tyr Asp Trp Leu Tyr Leu Gly Phe Met Ala 
65                  70                  75                  80  


Met Leu Pro Leu Val Leu His Trp Phe Phe Ile Glu Trp Tyr Ser Gly 
                85                  90                  95      


Lys Lys Ser Ser Ser Ala Leu Phe Gln His Ile Thr Ala Leu Phe Glu 
            100                 105                 110         


Cys Ser Met Ala Ala Ile Ile Thr Leu Leu Val Ser Asp Pro Val Gly 
        115                 120                 125             


Val Leu Tyr Ile Arg Ser Cys Arg Val Leu Met Leu Ser Asp Trp Tyr 
    130                 135                 140                 


Thr Met Leu Tyr Asn Pro Ser Pro Asp Tyr Val Thr Thr Val His Cys 
145                 150                 155                 160 


Thr His Glu Ala Val Tyr Pro Leu Tyr Thr Ile Val Phe Ile Tyr Tyr 
                165                 170                 175     


Ala Phe Cys Leu Val Leu Met Met Leu Leu Arg Pro Leu Leu Val Lys 
            180                 185                 190         


Lys Ile Ala Cys Gly Leu Gly Lys Ser Asp Arg Phe Lys Ser Ile Tyr 
        195                 200                 205             


Ala Ala Leu Tyr Phe Phe Pro Ile Leu Thr Val Leu Gln Ala Val Gly 
    210                 215                 220                 


Gly Gly Leu Leu Tyr Tyr Ala Phe Pro Tyr Ile Ile Leu Val Leu Ser 
225                 230                 235                 240 


Leu Val Thr Leu Ala Val Tyr Met Ser Ala Ser Glu Ile Glu Asn Cys 
                245                 250                 255     


Tyr Asp Leu Leu Val Arg Lys Lys Arg Leu Ile Val Leu Phe Ser His 
            260                 265                 270         


Trp Leu Leu His Ala Tyr Gly Ile Ile Ser Ile Ser Arg Val Asp Lys 
        275                 280                 285             


Leu Glu Gln Asp Leu Pro Leu Leu Ala Leu Val Pro Thr Pro Ala Leu 
    290                 295                 300                 


Phe Tyr Leu Phe Thr Ala Lys Phe Thr Glu Pro Ser Arg Ile Leu Ser 
305                 310                 315                 320 


Glu Gly Ala Asn Gly His 
                325     


<210>  183
<211>  438
<212>  PRT
<213>  homo sapiens

<400>  183

Gly Gly Gly Gly Gly His Ile Gly Val Arg Pro Gly Ser Thr Leu Cys 
1               5                   10                  15      


Gln Ile Ile Ala Thr Cys His Met Ser Val Asn Asp Gly Gly Cys Lys 
            20                  25                  30          


Tyr Val Leu Cys Arg Trp Glu Lys Arg Leu Trp Pro Ala Lys Val Leu 
        35                  40                  45              


Ala Arg Thr Ala Thr Ser Thr Lys Asn Lys Arg Arg Lys Glu Tyr Phe 
    50                  55                  60                  


Leu Ala Val Gln Ile Leu Ser Leu Glu Glu Lys Ile Lys Val Lys Ser 
65                  70                  75                  80  


Thr Glu Val Glu Ile Leu Glu Lys Ser Gln Ile Glu Ala Ile Ala Ser 
                85                  90                  95      


Ser Leu Ala Ser Gln Asn Glu Val Pro Ala Ala Pro Leu Glu Glu Leu 
            100                 105                 110         


Ala Tyr Arg Arg Ser Leu Arg Val Ala Leu Asp Val Leu Ser Glu Gly 
        115                 120                 125             


Ser Ile Trp Ser Gln Glu Ser Ser Ala Gly Thr Gly Arg Ala Asp Arg 
    130                 135                 140                 


Ser Leu Arg Gly Lys Pro Met Glu His Val Ser Ser Pro Cys Asp Ser 
145                 150                 155                 160 


Asn Ser Ser Ser Leu Pro Arg Gly Asp Val Leu Gly Ser Ser Arg Pro 
                165                 170                 175     


His Arg Arg Arg Pro Cys Val Gln Gln Ser Leu Ser Ser Ser Phe Thr 
            180                 185                 190         


Cys Glu Lys Asp Pro Glu Cys Lys Val Asp His Lys Lys Gly Leu Arg 
        195                 200                 205             


Lys Ser Glu Asn Pro Arg Gly Pro Leu Val Leu Pro Ala Gly Gly Gly 
    210                 215                 220                 


Ala Gln Asp Glu Ser Gly Ser Arg Ile His His Lys Asn Trp Thr Leu 
225                 230                 235                 240 


Ala Ser Lys Arg Gly Arg Asn Ser Ala Gln Lys Ala Ser Leu Cys Leu 
                245                 250                 255     


Asn Gly Ser Ser Leu Ser Glu Asp Asp Thr Glu Arg Asp Met Gly Ser 
            260                 265                 270         


Lys Gly Gly Ser Trp Ala Ala Pro Ser Leu Pro Ser Gly Val Arg Glu 
        275                 280                 285             


Asp Asp Pro Cys Ala Asn Ala Glu Gly His Asp Pro Gly Leu Pro Leu 
    290                 295                 300                 


Gly Ser Leu Thr Ala Pro Pro Ala Pro Glu Pro Ser Ala Cys Ser Glu 
305                 310                 315                 320 


Pro Gly Glu Cys Pro Ala Lys Lys Arg Pro Arg Leu Asp Gly Ser Gln 
                325                 330                 335     


Arg Pro Pro Ala Val Gln Leu Glu Pro Met Ala Ala Gly Ala Ala Pro 
            340                 345                 350         


Ser Pro Gly Pro Gly Pro Gly Pro Arg Glu Ser Val Thr Pro Arg Ser 
        355                 360                 365             


Thr Ala Arg Leu Gly Pro Pro Pro Ser His Ala Ser Ala Asp Ala Thr 
    370                 375                 380                 


Arg Cys Leu Pro Cys Pro Asp Ser Gln Lys Leu Glu Lys Glu Cys Gln 
385                 390                 395                 400 


Ser Ser Glu Glu Ser Met Gly Ser Asn Ser Met Arg Ser Ile Leu Glu 
                405                 410                 415     


Glu Asp Glu Glu Asp Glu Glu Pro Pro Arg Val Leu Leu Tyr His Glu 
            420                 425                 430         


Pro Arg Ser Phe Glu Val 
        435             


<210>  184
<211>  1533
<212>  PRT
<213>  homo sapiens

<400>  184

Met Tyr Ile Arg Val Ser Tyr Asp Thr Lys Pro Asp Ser Leu Leu His 
1               5                   10                  15      


Leu Met Val Lys Asp Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Met Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Ser Thr Gly Val Ile Ser His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ser Ser Lys Ser Arg Gly Arg Val Cys Ala Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Lys Glu Asp Leu Val Gly 
            100                 105                 110         


Lys Asp Val Thr Arg Val Tyr Gln Thr Met Ser Asn Pro Leu Ser Lys 
        115                 120                 125             


Leu Ser Val Leu Asn Asn Ser His Thr His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Leu Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Leu Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Leu Gly Gln Gly 
                165                 170                 175     


Val Pro Leu Val Gly Leu Val Val Glu Gly Gly Pro Asn Val Val Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Gln Glu Glu Pro Pro Ile Pro Val Val Ile 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ser Phe Ala His Lys 
    210                 215                 220                 


Tyr Cys Glu Glu Gly Gly Ile Ile Asn Glu Ser Leu Arg Glu Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Asn Tyr Asn Lys Ala Gln Ser His 
                245                 250                 255     


Gln Leu Phe Ala Ile Ile Met Glu Cys Met Lys Lys Lys Glu Leu Val 
            260                 265                 270         


Thr Val Phe Arg Met Gly Ser Glu Gly Gln Gln Asp Ile Glu Met Ala 
        275                 280                 285             


Ile Leu Thr Ala Leu Leu Lys Gly Thr Asn Val Ser Ala Pro Asp Gln 
    290                 295                 300                 


Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln 
305                 310                 315                 320 


Ile Phe Val Phe Gly Pro His Trp Thr Pro Leu Gly Ser Leu Ala Pro 
                325                 330                 335     


Pro Thr Asp Ser Lys Ala Thr Glu Lys Glu Lys Lys Pro Pro Met Ala 
            340                 345                 350         


Thr Thr Lys Gly Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys Gly Lys 
        355                 360                 365             


Val Lys Glu Glu Val Glu Glu Glu Thr Asp Pro Arg Lys Ile Glu Leu 
    370                 375                 380                 


Leu Asn Trp Val Asn Ala Leu Glu Gln Ala Met Leu Asp Ala Leu Val 
385                 390                 395                 400 


Leu Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Asn 
                405                 410                 415     


Met Gln His Phe Leu Thr Ile Pro Arg Leu Glu Glu Leu Tyr Asn Thr 
            420                 425                 430         


Arg Leu Gly Pro Pro Asn Thr Leu His Leu Leu Val Arg Asp Val Lys 
        435                 440                 445             


Lys Ser Asn Leu Pro Pro Asp Tyr His Ile Ser Leu Ile Asp Ile Gly 
    450                 455                 460                 


Leu Val Leu Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr 
465                 470                 475                 480 


Arg Lys Asn Phe Arg Thr Leu Tyr Asn Asn Leu Phe Gly Pro Lys Arg 
                485                 490                 495     


Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Glu Pro Pro Ala 
            500                 505                 510         


Lys Gly Lys Lys Lys Lys Lys Lys Lys Lys Glu Glu Glu Ile Asp Ile 
        515                 520                 525             


Asp Val Asp Asp Pro Ala Val Ser Arg Phe Gln Tyr Pro Phe His Glu 
    530                 535                 540                 


Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Val Phe 
545                 550                 555                 560 


Leu Trp Gln Arg Gly Glu Glu Ser Met Ala Lys Ala Leu Val Ala Cys 
                565                 570                 575     


Lys Leu Tyr Lys Ala Met Ala His Glu Ser Ser Glu Ser Asp Leu Val 
            580                 585                 590         


Asp Asp Ile Ser Gln Asp Leu Asp Asn Asn Ser Lys Asp Phe Gly Gln 
        595                 600                 605             


Leu Ala Leu Glu Leu Leu Asp Gln Ser Tyr Lys His Asp Glu Gln Ile 
    610                 615                 620                 


Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ser Thr 
625                 630                 635                 640 


Cys Leu Lys Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His 
                645                 650                 655     


Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg 
            660                 665                 670         


Met Arg Lys Asn Pro Gly Leu Lys Val Ile Met Gly Ile Leu Leu Pro 
        675                 680                 685             


Pro Thr Ile Leu Phe Leu Glu Phe Arg Thr Tyr Asp Asp Phe Ser Tyr 
    690                 695                 700                 


Gln Thr Ser Lys Glu Asn Glu Asp Gly Lys Glu Lys Glu Glu Glu Asn 
705                 710                 715                 720 


Thr Asp Ala Asn Ala Asp Ala Gly Ser Arg Lys Gly Asp Glu Glu Asn 
                725                 730                 735     


Glu His Lys Lys Gln Arg Ser Ile Pro Ile Gly Thr Lys Ile Cys Glu 
            740                 745                 750         


Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Ile Ser Tyr 
        755                 760                 765             


Leu Gly Tyr Leu Leu Leu Phe Asn Tyr Val Ile Leu Val Arg Met Asp 
    770                 775                 780                 


Gly Trp Pro Ser Leu Gln Glu Trp Ile Val Ile Ser Tyr Ile Val Ser 
785                 790                 795                 800 


Leu Ala Leu Glu Lys Ile Arg Glu Ile Leu Met Ser Glu Pro Gly Lys 
                805                 810                 815     


Leu Ser Gln Lys Ile Lys Val Trp Leu Gln Glu Tyr Trp Asn Ile Thr 
            820                 825                 830         


Asp Leu Val Ala Ile Ser Thr Phe Met Ile Gly Ala Ile Leu Arg Leu 
        835                 840                 845             


Gln Asn Gln Pro Tyr Met Gly Tyr Gly Arg Val Ile Tyr Cys Val Asp 
    850                 855                 860                 


Ile Ile Phe Trp Tyr Ile Arg Val Leu Asp Ile Phe Gly Val Asn Lys 
865                 870                 875                 880 


Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met 
                885                 890                 895     


Leu Tyr Phe Val Val Ile Met Leu Val Val Leu Met Ser Phe Gly Val 
            900                 905                 910         


Ala Arg Gln Ala Ile Leu His Pro Glu Glu Lys Pro Ser Trp Lys Leu 
        915                 920                 925             


Ala Arg Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val 
    930                 935                 940                 


Phe Ala Asp Gln Ile Asp Leu Tyr Ala Met Glu Ile Asn Pro Pro Cys 
945                 950                 955                 960 


Gly Glu Asn Leu Tyr Asp Glu Glu Gly Lys Arg Leu Pro Pro Cys Ile 
                965                 970                 975     


Pro Gly Ala Trp Leu Thr Pro Ala Leu Met Ala Cys Tyr Leu Leu Val 
            980                 985                 990         


Ala Asn Ile Leu Leu Val Asn Leu  Leu Ile Ala Val Phe  Asn Asn Thr 
        995                 1000                 1005             


Phe Phe  Glu Val Lys Ser Ile  Ser Asn Gln Val Trp  Lys Phe Gln 
    1010                 1015                 1020             


Arg Tyr  Gln Leu Ile Met Thr  Phe His Asp Arg Pro  Val Leu Pro 
    1025                 1030                 1035             


Pro Pro  Met Ile Ile Leu Ser  His Ile Tyr Ile Ile  Ile Met Arg 
    1040                 1045                 1050             


Leu Ser  Gly Arg Cys Arg Lys  Lys Arg Glu Gly Asp  Gln Glu Glu 
    1055                 1060                 1065             


Arg Asp  Arg Gly Leu Lys Leu  Phe Leu Ser Asp Glu  Glu Leu Lys 
    1070                 1075                 1080             


Arg Leu  His Glu Phe Glu Glu  Gln Cys Val Gln Glu  His Phe Arg 
    1085                 1090                 1095             


Glu Lys  Glu Asp Glu Gln Gln  Ser Ser Ser Asp Glu  Arg Ile Arg 
    1100                 1105                 1110             


Val Thr  Ser Glu Arg Val Glu  Asn Met Ser Met Arg  Leu Glu Glu 
    1115                 1120                 1125             


Ile Asn  Glu Arg Glu Thr Phe  Met Lys Thr Ser Leu  Gln Thr Val 
    1130                 1135                 1140             


Asp Leu  Arg Leu Ala Gln Leu  Glu Glu Leu Ser Asn  Arg Met Val 
    1145                 1150                 1155             


Asn Ala  Leu Glu Asn Leu Ala  Gly Ile Asp Arg Ser  Asp Leu Ile 
    1160                 1165                 1170             


Gln Ala  Arg Ser Arg Ala Ser  Ser Glu Cys Glu Ala  Thr Tyr Leu 
    1175                 1180                 1185             


Leu Arg  Gln Ser Ser Ile Asn  Ser Ala Asp Gly Tyr  Ser Leu Tyr 
    1190                 1195                 1200             


Arg Tyr  His Phe Asn Gly Glu  Glu Leu Leu Phe Glu  Asp Thr Ser 
    1205                 1210                 1215             


Leu Ser  Thr Ser Pro Gly Thr  Gly Val Arg Lys Lys  Thr Cys Ser 
    1220                 1225                 1230             


Phe Arg  Ile Lys Glu Glu Lys  Asp Val Lys Thr His  Leu Val Pro 
    1235                 1240                 1245             


Glu Cys  Gln Asn Ser Leu His  Leu Ser Leu Gly Thr  Ser Thr Ser 
    1250                 1255                 1260             


Ala Thr  Pro Asp Gly Ser His  Leu Ala Val Asp Asp  Leu Lys Asn 
    1265                 1270                 1275             


Ala Glu  Glu Ser Lys Leu Gly  Pro Asp Ile Gly Ile  Ser Lys Glu 
    1280                 1285                 1290             


Asp Asp  Glu Arg Gln Thr Asp  Ser Lys Lys Glu Glu  Thr Ile Ser 
    1295                 1300                 1305             


Pro Ser  Leu Asn Lys Thr Asp  Val Ile His Gly Gln  Asp Lys Ser 
    1310                 1315                 1320             


Asp Val  Gln Asn Thr Gln Leu  Thr Val Glu Thr Thr  Asn Ile Glu 
    1325                 1330                 1335             


Gly Thr  Ile Ser Tyr Pro Leu  Glu Glu Thr Lys Ile  Thr Arg Tyr 
    1340                 1345                 1350             


Phe Pro  Asp Glu Thr Ile Asn  Ala Cys Lys Thr Met  Lys Ser Arg 
    1355                 1360                 1365             


Ser Phe  Val Tyr Ser Arg Gly  Arg Lys Leu Val Gly  Gly Val Asn 
    1370                 1375                 1380             


Gln Asp  Val Glu Tyr Ser Ser  Ile Thr Asp Gln Gln  Leu Thr Thr 
    1385                 1390                 1395             


Glu Trp  Gln Cys Gln Val Gln  Lys Ile Thr Arg Ser  His Ser Thr 
    1400                 1405                 1410             


Asp Ile  Pro Tyr Ile Val Ser  Glu Ala Ala Val Gln  Ala Glu Gln 
    1415                 1420                 1425             


Lys Glu  Gln Phe Ala Asp Met  Gln Asp Glu His His  Val Ala Glu 
    1430                 1435                 1440             


Ala Ile  Pro Arg Ile Pro Arg  Leu Ser Leu Thr Ile  Thr Asp Arg 
    1445                 1450                 1455             


Asn Gly  Met Glu Asn Leu Leu  Ser Val Lys Pro Asp  Gln Thr Leu 
    1460                 1465                 1470             


Gly Phe  Pro Ser Leu Arg Ser  Lys Ser Leu His Gly  His Pro Arg 
    1475                 1480                 1485             


Asn Val  Lys Ser Ile Gln Gly  Lys Leu Asp Arg Ser  Gly His Ala 
    1490                 1495                 1500             


Ser Ser  Val Ser Ser Leu Val  Ile Val Ser Gly Met  Thr Ala Glu 
    1505                 1510                 1515             


Glu Lys  Lys Val Lys Lys Glu  Lys Ala Ser Thr Glu  Thr Glu Cys 
    1520                 1525                 1530             


<210>  185
<211>  5596
<212>  PRT
<213>  homo sapiens

<400>  185

Met Glu His Phe Leu Leu Glu Val Ala Ala Ala Pro Leu Arg Leu Ile 
1               5                   10                  15      


Ala Ala Lys Asn Glu Lys Ser Arg Ser Glu Leu Gly Arg Phe Leu Ala 
            20                  25                  30          


Lys Gln Val Trp Thr Pro Gln Asp Arg Gln Cys Val Leu Ser Thr Leu 
        35                  40                  45              


Ala Gln Leu Leu Leu Asp Lys Asp Cys Thr Val Leu Val Gly Arg Gln 
    50                  55                  60                  


Leu Arg Pro Leu Leu Leu Asp Leu Leu Glu Arg Asn Ala Glu Ala Ile 
65                  70                  75                  80  


Lys Ala Gly Gly Gln Ile Asn His Asp Leu His Glu Arg Leu Cys Val 
                85                  90                  95      


Ser Met Ser Lys Leu Ile Gly Asn His Pro Asp Val Leu Pro Phe Ala 
            100                 105                 110         


Leu Arg Tyr Phe Lys Asp Thr Ser Pro Val Phe Gln Arg Leu Phe Leu 
        115                 120                 125             


Glu Ser Ser Asp Ala Asn Pro Val Arg Tyr Gly Arg Arg Arg Met Lys 
    130                 135                 140                 


Leu Arg Asp Leu Met Glu Ala Ala Phe Lys Phe Leu Gln Gln Glu Gln 
145                 150                 155                 160 


Ser Val Phe Arg Glu Leu Trp Asp Trp Ser Val Cys Val Pro Leu Leu 
                165                 170                 175     


Arg Ser His Asp Thr Leu Val Arg Trp Tyr Thr Ala Asn Cys Leu Ala 
            180                 185                 190         


Leu Val Thr Cys Met Asn Glu Glu His Lys Leu Ser Phe Leu Lys Lys 
        195                 200                 205             


Ile Phe Asn Ser Asp Glu Leu Ile His Phe Arg Leu Arg Leu Leu Glu 
    210                 215                 220                 


Glu Ala Gln Leu Gln Asp Leu Glu Lys Ala Leu Val Leu Ala Asn Pro 
225                 230                 235                 240 


Glu Val Ser Leu Trp Arg Lys Gln Lys Glu Leu Gln Tyr Leu Gln Gly 
                245                 250                 255     


His Leu Val Ser Ser Asp Leu Ser Pro Arg Val Thr Ala Val Cys Gly 
            260                 265                 270         


Val Val Leu Pro Gly Gln Leu Pro Ala Pro Gly Glu Leu Gly Gly Asn 
        275                 280                 285             


Arg Ser Ser Ser Arg Glu Gln Glu Leu Ala Leu Arg Ser Tyr Val Leu 
    290                 295                 300                 


Val Glu Ser Val Cys Lys Ser Leu Gln Thr Leu Ala Met Ala Val Ala 
305                 310                 315                 320 


Ser Gln Asn Ala Val Leu Leu Glu Gly Pro Ile Gly Cys Gly Lys Thr 
                325                 330                 335     


Ser Leu Val Glu Tyr Leu Ala Ala Val Thr Gly Arg Thr Lys Pro Pro 
            340                 345                 350         


Gln Leu Leu Lys Val Gln Leu Gly Asp Gln Thr Asp Ser Lys Met Leu 
        355                 360                 365             


Leu Gly Met Tyr Arg Cys Thr Asp Val Pro Gly Glu Phe Val Trp Gln 
    370                 375                 380                 


Pro Gly Thr Leu Thr Gln Ala Ala Thr Met Gly His Trp Ile Leu Leu 
385                 390                 395                 400 


Glu Asp Ile Asp Tyr Ala Pro Leu Asp Val Val Ser Val Leu Ile Pro 
                405                 410                 415     


Leu Leu Glu Asn Gly Glu Leu Leu Ile Pro Gly Arg Gly Asp Cys Leu 
            420                 425                 430         


Lys Val Ala Pro Gly Phe Gln Phe Phe Ala Thr Arg Arg Leu Leu Ser 
        435                 440                 445             


Cys Gly Gly Asn Trp Tyr Arg Pro Leu Asn Ser His Ala Thr Leu Leu 
    450                 455                 460                 


Asp Lys Tyr Trp Thr Lys Ile His Leu Asp Asn Leu Asp Lys Arg Glu 
465                 470                 475                 480 


Leu Asn Glu Val Leu Gln Ser Arg Tyr Pro Ser Leu Leu Ala Val Val 
                485                 490                 495     


Asp His Leu Leu Asp Ile Tyr Ile Gln Leu Thr Gly Glu Lys His His 
            500                 505                 510         


Ser Trp Ser Asp Ser Ser Val Gly Cys Glu Gln Ala Pro Glu Glu Val 
        515                 520                 525             


Ser Glu Ala Arg Arg Glu Asn Lys Arg Pro Thr Leu Glu Gly Arg Glu 
    530                 535                 540                 


Leu Ser Leu Arg Asp Leu Leu Asn Trp Cys Asn Arg Ile Ala His Ser 
545                 550                 555                 560 


Phe Asp Ser Ser Ser Leu Ser Ala Ser Leu Asn Ile Phe Gln Glu Ala 
                565                 570                 575     


Leu Asp Cys Phe Thr Ala Met Leu Ser Glu His Thr Ser Lys Leu Lys 
            580                 585                 590         


Met Ala Glu Val Ile Gly Ser Lys Leu Asn Ile Ser Arg Lys Lys Ala 
        595                 600                 605             


Glu Phe Phe Cys Gln Leu Tyr Lys Pro Glu Ile Val Ile Asn Glu Leu 
    610                 615                 620                 


Asp Leu Gln Val Gly Arg Val Arg Leu Leu Arg Lys Gln Ser Glu Ala 
625                 630                 635                 640 


Val His Leu Gln Arg Glu Lys Phe Thr Phe Ala Ala Thr Arg Pro Ser 
                645                 650                 655     


Ser Val Leu Ile Glu Gln Leu Ala Val Cys Val Ser Lys Gly Glu Pro 
            660                 665                 670         


Val Leu Leu Val Gly Glu Thr Gly Thr Gly Lys Thr Ser Thr Ile Gln 
        675                 680                 685             


Tyr Leu Ala His Ile Thr Gly His Arg Leu Arg Val Val Asn Met Asn 
    690                 695                 700                 


Gln Gln Ser Asp Thr Ala Asp Leu Leu Gly Gly Tyr Lys Pro Val Asp 
705                 710                 715                 720 


His Lys Leu Ile Trp Leu Pro Leu Arg Glu Ala Phe Glu Glu Leu Phe 
                725                 730                 735     


Ala Gln Thr Phe Ser Lys Lys Gln Asn Phe Thr Phe Leu Gly His Ile 
            740                 745                 750         


Gln Thr Cys Tyr Arg Gln Lys Arg Trp His Asp Leu Leu Arg Leu Met 
        755                 760                 765             


Gln His Val His Lys Ser Ala Val Asn Lys Asp Gly Lys Asp Ser Glu 
    770                 775                 780                 


Thr Gly Leu Leu Ile Lys Glu Lys Trp Glu Ala Phe Gly Leu Arg Leu 
785                 790                 795                 800 


Asn His Ala Gln Gln Gln Met Lys Met Thr Glu Asn Thr Leu Leu Phe 
                805                 810                 815     


Ala Phe Val Glu Gly Thr Leu Ala Gln Ala Val Lys Lys Gly Glu Trp 
            820                 825                 830         


Ile Leu Leu Asp Glu Ile Asn Leu Ala Ala Pro Glu Ile Leu Glu Cys 
        835                 840                 845             


Leu Ser Gly Leu Leu Glu Gly Ser Ser Gly Ser Leu Val Leu Leu Asp 
    850                 855                 860                 


Arg Gly Asp Thr Glu Pro Leu Val Arg His Pro Asp Phe Arg Leu Phe 
865                 870                 875                 880 


Ala Cys Met Asn Pro Ala Thr Asp Val Gly Lys Arg Asn Leu Pro Pro 
                885                 890                 895     


Gly Ile Arg Asn Arg Phe Thr Glu Leu Tyr Val Glu Glu Leu Glu Ser 
            900                 905                 910         


Lys Glu Asp Leu Gln Val Leu Ile Val Asp Tyr Leu Lys Gly Leu Ser 
        915                 920                 925             


Val Asn Lys Asn Thr Val Gln Gly Ile Ile Asn Phe Tyr Thr Ala Leu 
    930                 935                 940                 


Arg Lys Glu Ser Gly Thr Lys Leu Val Asp Gly Thr Gly His Arg Pro 
945                 950                 955                 960 


His Tyr Ser Leu Arg Thr Leu Cys Arg Ala Leu Arg Phe Ala Ala Ser 
                965                 970                 975     


Asn Pro Cys Gly Asn Ile Gln Arg Ser Leu Tyr Glu Gly Phe Cys Leu 
            980                 985                 990         


Gly Phe Leu Thr Gln Leu Asp Arg  Ala Ser His Pro Ile  Val Gln Lys 
        995                 1000                 1005             


Leu Ile  Cys Gln His Ile Val  Pro Gly Asn Val Lys  Ser Leu Leu 
    1010                 1015                 1020             


Lys Gln  Pro Ile Pro Glu Pro  Lys Gly Gly Arg Leu  Ile Gln Val 
    1025                 1030                 1035             


Glu Gly  Tyr Trp Ile Ala Val  Gly Asp Lys Glu Pro  Thr Ile Asp 
    1040                 1045                 1050             


Glu Thr  Tyr Ile Leu Thr Ser  Ser Val Lys Leu Asn  Leu Arg Asp 
    1055                 1060                 1065             


Ile Val  Arg Val Val Ser Ala  Gly Thr Tyr Pro Val  Leu Ile Gln 
    1070                 1075                 1080             


Gly Glu  Thr Ser Val Gly Lys  Thr Ser Leu Ile Gln  Trp Leu Ala 
    1085                 1090                 1095             


Ala Ala  Thr Gly Asn His Cys  Val Arg Ile Asn Asn  His Glu His 
    1100                 1105                 1110             


Thr Asp  Ile Gln Glu Tyr Ile  Gly Cys Tyr Thr Ser  Asp Ser Ser 
    1115                 1120                 1125             


Gly Lys  Leu Val Phe Lys Glu  Gly Val Leu Ile Asp  Ala Met Arg 
    1130                 1135                 1140             


Lys Gly  Tyr Trp Ile Ile Leu  Asp Glu Leu Asn Leu  Ala Pro Thr 
    1145                 1150                 1155             


Asp Val  Leu Glu Ala Leu Asn  Arg Leu Leu Asp Asp  Asn Arg Glu 
    1160                 1165                 1170             


Leu Leu  Val Thr Glu Thr Gln  Glu Val Val Lys Ala  His Pro Arg 
    1175                 1180                 1185             


Phe Met  Leu Phe Ala Thr Gln  Asn Pro Pro Gly Leu  Tyr Gly Gly 
    1190                 1195                 1200             


Arg Lys  Val Leu Ser Arg Ala  Phe Arg Asn Arg Phe  Val Glu Leu 
    1205                 1210                 1215             


His Phe  Asp Glu Leu Pro Ser  Ser Glu Leu Glu Thr  Ile Leu His 
    1220                 1225                 1230             


Lys Arg  Cys Ser Leu Pro Pro  Ser Tyr Cys Ser Lys  Leu Val Lys 
    1235                 1240                 1245             


Val Met  Leu Asp Leu Gln Ser  Tyr Arg Arg Ser Ser  Ser Val Phe 
    1250                 1255                 1260             


Ala Gly  Lys Gln Gly Phe Ile  Thr Leu Arg Asp Leu  Phe Arg Trp 
    1265                 1270                 1275             


Ala Glu  Arg Tyr Arg Leu Ala  Glu Pro Thr Glu Lys  Glu Tyr Asp 
    1280                 1285                 1290             


Trp Leu  Gln His Leu Ala Asn  Asp Gly Tyr Met Leu  Leu Ala Gly 
    1295                 1300                 1305             


Arg Val  Arg Lys Gln Glu Glu  Ile Asp Val Ile Gln  Glu Val Leu 
    1310                 1315                 1320             


Glu Lys  His Phe Lys Lys Lys  Leu Cys Pro Gln Ser  Leu Phe Ser 
    1325                 1330                 1335             


Lys Glu  Asn Val Leu Lys Leu  Leu Gly Lys Leu Ser  Thr Gln Ile 
    1340                 1345                 1350             


Ser Thr  Leu Glu Cys Asn Phe  Gly His Ile Val Trp  Thr Glu Gly 
    1355                 1360                 1365             


Met Arg  Arg Leu Ala Met Leu  Val Gly Arg Ala Leu  Glu Phe Gly 
    1370                 1375                 1380             


Glu Pro  Val Leu Leu Val Gly  Asp Thr Gly Cys Gly  Lys Thr Thr 
    1385                 1390                 1395             


Ile Cys  Gln Val Phe Ala Ala  Leu Ala Asn Gln Lys  Leu Tyr Ser 
    1400                 1405                 1410             


Val Ser  Cys His Leu His Met  Glu Thr Ser Asp Phe  Leu Gly Gly 
    1415                 1420                 1425             


Leu Arg  Pro Val Arg Gln Lys  Pro Asn Asp Lys Glu  Glu Ile Asp 
    1430                 1435                 1440             


Thr Ser  Arg Leu Phe Glu Trp  His Asp Gly Pro Leu  Val Gln Ala 
    1445                 1450                 1455             


Met Lys  Glu Asp Gly Phe Phe  Leu Leu Asp Glu Ile  Ser Leu Ala 
    1460                 1465                 1470             


Asp Asp  Ser Val Leu Glu Arg  Leu Asn Ser Val Leu  Glu Val Glu 
    1475                 1480                 1485             


Lys Ser  Leu Val Leu Ala Glu  Lys Gly Ser Pro Glu  Asp Lys Asp 
    1490                 1495                 1500             


Ser Glu  Ile Glu Leu Leu Thr  Ala Gly Lys Lys Phe  Arg Ile Leu 
    1505                 1510                 1515             


Ala Thr  Met Asn Pro Gly Gly  Asp Phe Gly Lys Lys  Glu Leu Ser 
    1520                 1525                 1530             


Pro Ala  Leu Arg Asn Arg Phe  Thr Glu Ile Trp Cys  Pro Gln Ser 
    1535                 1540                 1545             


Thr Ser  Arg Glu Asp Leu Ile  Gln Ile Ile Ser His  Asn Leu Arg 
    1550                 1555                 1560             


Pro Gly  Leu Cys Leu Gly Arg  Ile Asp Pro Lys Gly  Ser Asp Ile 
    1565                 1570                 1575             


Pro Glu  Val Met Leu Asp Phe  Ile Asp Trp Leu Thr  His Gln Glu 
    1580                 1585                 1590             


Phe Gly  Arg Lys Cys Val Val  Ser Ile Arg Asp Ile  Leu Ser Trp 
    1595                 1600                 1605             


Val Asn  Phe Met Asn Lys Met  Gly Glu Glu Ala Ala  Leu Lys Arg 
    1610                 1615                 1620             


Pro Glu  Ile Ile Ser Thr Val  Thr Ser Phe Val His  Ala Ala Cys 
    1625                 1630                 1635             


Leu Val  Tyr Ile Asp Gly Ile  Gly Ser Gly Val Thr  Ser Ser Gly 
    1640                 1645                 1650             


Phe Gly  Thr Ala Leu Leu Ala  Arg Lys Glu Cys Leu  Lys Phe Leu 
    1655                 1660                 1665             


Ile Lys  Arg Leu Ala Lys Ile  Val Arg Leu Thr Glu  Tyr Gln Lys 
    1670                 1675                 1680             


Asn Glu  Leu Lys Ile Tyr Asp  Arg Met Lys Ala Lys  Glu Phe Thr 
    1685                 1690                 1695             


Gly Ile  Asp Asn Leu Trp Gly  Ile His Pro Phe Phe  Ile Pro Arg 
    1700                 1705                 1710             


Gly Pro  Val Leu His Arg Asn  Asn Ile Ala Asp Tyr  Ala Leu Ser 
    1715                 1720                 1725             


Ala Gly  Thr Thr Ala Met Asn  Ala Gln Arg Leu Leu  Arg Ala Thr 
    1730                 1735                 1740             


Lys Leu  Lys Lys Pro Ile Leu  Leu Glu Gly Ser Pro  Gly Val Gly 
    1745                 1750                 1755             


Lys Thr  Ser Leu Val Gly Ala  Leu Ala Lys Ala Ser  Gly Asn Thr 
    1760                 1765                 1770             


Leu Val  Arg Ile Asn Leu Ser  Glu Gln Thr Asp Ile  Thr Asp Leu 
    1775                 1780                 1785             


Phe Gly  Ala Asp Leu Pro Val  Glu Gly Gly Lys Gly  Gly Glu Phe 
    1790                 1795                 1800             


Ala Trp  Arg Asp Gly Pro Leu  Leu Ala Ala Leu Lys  Ala Gly His 
    1805                 1810                 1815             


Trp Val  Val Leu Asp Glu Leu  Asn Leu Ala Ser Gln  Ser Val Leu 
    1820                 1825                 1830             


Glu Gly  Leu Asn Ala Cys Phe  Asp His Arg Gly Glu  Ile Tyr Val 
    1835                 1840                 1845             


Pro Glu  Leu Gly Met Ser Phe  Gln Val Gln His Glu  Lys Thr Lys 
    1850                 1855                 1860             


Ile Phe  Gly Cys Gln Asn Pro  Phe Arg Gln Gly Gly  Gly Arg Lys 
    1865                 1870                 1875             


Gly Leu  Pro Arg Ser Phe Leu  Asn Arg Phe Thr Gln  Val Phe Val 
    1880                 1885                 1890             


Asp Pro  Leu Thr Val Ile Asp  Met Glu Phe Ile Ala  Ser Thr Leu 
    1895                 1900                 1905             


Phe Pro  Ala Ile Glu Lys Asn  Ile Val Lys Lys Met  Val Ala Phe 
    1910                 1915                 1920             


Asn Asn  Gln Ile Asp His Glu  Val Thr Val Glu Lys  Lys Trp Gly 
    1925                 1930                 1935             


Gln Lys  Gly Gly Pro Trp Glu  Phe Asn Leu Arg Asp  Leu Phe Arg 
    1940                 1945                 1950             


Trp Cys  Gln Leu Met Leu Val  Asp Gln Ser Pro Gly  Cys Tyr Asp 
    1955                 1960                 1965             


Pro Gly  Gln His Val Phe Leu  Val Tyr Gly Glu Arg  Met Arg Thr 
    1970                 1975                 1980             


Glu Glu  Asp Lys Lys Lys Val  Ile Ala Val Phe Lys  Asp Val Phe 
    1985                 1990                 1995             


Gly Ser  Asn Ser Asn Pro Tyr  Met Gly Thr Arg Leu  Phe Arg Ile 
    2000                 2005                 2010             


Thr Pro  Tyr Asp Val Gln Leu  Gly Tyr Ser Val Leu  Ser Arg Gly 
    2015                 2020                 2025             


Ser Cys  Val Pro His Pro Ser  Arg His Pro Leu Leu  Leu Leu His 
    2030                 2035                 2040             


Gln Ser  Phe Gln Pro Leu Glu  Ser Ile Met Lys Cys  Val Gln Met 
    2045                 2050                 2055             


Ser Trp  Met Val Ile Leu Val  Gly Pro Ala Ser Val  Gly Lys Thr 
    2060                 2065                 2070             


Ser Leu  Val Gln Leu Leu Ala  His Leu Thr Gly His  Thr Leu Lys 
    2075                 2080                 2085             


Ile Met  Ala Met Asn Ser Ala  Met Asp Thr Thr Glu  Leu Leu Gly 
    2090                 2095                 2100             


Gly Phe  Glu Gln Val Asp Leu  Ile Arg Pro Trp Arg  Arg Leu Leu 
    2105                 2110                 2115             


Glu Lys  Val Glu Gly Thr Val  Arg Ala Leu Leu Arg  Asp Ser Leu 
    2120                 2125                 2130             


Leu Ile  Ser Ala Asp Asp Ala  Glu Val Val Leu Arg  Ala Trp Ser 
    2135                 2140                 2145             


His Phe  Leu Leu Thr Tyr Lys  Pro Lys Cys Leu Gly  Glu Gly Gly 
    2150                 2155                 2160             


Lys Ala  Ile Thr Met Glu Ile  Val Asn Lys Leu Glu  Ala Val Leu 
    2165                 2170                 2175             


Leu Leu  Met Gln Arg Leu Asn  Asn Lys Ile Asn Ser  Tyr Cys Lys 
    2180                 2185                 2190             


Ala Glu  Phe Ala Lys Leu Val  Glu Glu Phe Arg Ser  Phe Gly Val 
    2195                 2200                 2205             


Lys Leu  Thr Gln Leu Ala Ser  Gly His Ser His Gly  Thr Phe Glu 
    2210                 2215                 2220             


Trp Val  Asp Ser Met Leu Val  Gln Ala Leu Lys Ser  Gly Asp Trp 
    2225                 2230                 2235             


Leu Leu  Met Asp Asn Val Asn  Phe Cys Asn Pro Ser  Val Leu Asp 
    2240                 2245                 2250             


Arg Leu  Asn Ala Leu Leu Glu  Pro Gly Gly Val Leu  Thr Ile Ser 
    2255                 2260                 2265             


Glu Arg  Gly Met Ile Asp Gly  Ser Thr Pro Thr Ile  Thr Pro Asn 
    2270                 2275                 2280             


Pro Asn  Phe Arg Leu Phe Leu  Ser Met Asp Pro Val  His Gly Asp 
    2285                 2290                 2295             


Ile Ser  Arg Ala Met Arg Asn  Arg Gly Leu Glu Ile  Tyr Ile Ser 
    2300                 2305                 2310             


Gly Glu  Gly Asp Ala Ser Thr  Pro Asp Asn Leu Asp  Leu Lys Val 
    2315                 2320                 2325             


Leu Leu  His Ser Leu Gly Leu  Val Gly Asn Ser Val  Cys Asp Ile 
    2330                 2335                 2340             


Leu Leu  Ala Leu His Thr Glu  Thr Arg Ser Thr Val  Val Gly Ser 
    2345                 2350                 2355             


Pro Thr  Ser Ser Val Ser Thr  Leu Ile Gln Thr Ala  Ile Leu Ile 
    2360                 2365                 2370             


Val Gln  Tyr Leu Gln Arg Gly  Leu Ser Leu Asp Arg  Ala Phe Ser 
    2375                 2380                 2385             


Glu Ala  Cys Trp Glu Val Tyr  Val Cys Ser Gln His  Ser Pro Ala 
    2390                 2395                 2400             


Asn Arg  Lys Leu Val Gln Ala  Leu Leu Glu Lys His  Val Ser Ser 
    2405                 2410                 2415             


Leu Arg  Ala His Glu Thr Trp  Gly Asp Ser Ile Leu  Gly Met Gly 
    2420                 2425                 2430             


Leu Trp  Pro Asp Ser Val Pro  Ser Ala Leu Phe Ala  Thr Glu Asp 
    2435                 2440                 2445             


Ser His  Leu Ser Thr Val Arg  Arg Asp Gly Gln Ile  Leu Val Tyr 
    2450                 2455                 2460             


Cys Leu  Asn Arg Met Ser Met  Lys Thr Ser Ser Trp  Thr Arg Ser 
    2465                 2470                 2475             


Gln Pro  Phe Thr Leu Gln Asp  Leu Glu Lys Ile Met  Gln Ser Pro 
    2480                 2485                 2490             


Ser Pro  Glu Asn Leu Lys Phe  Asn Ala Val Glu Val  Asn Thr Tyr 
    2495                 2500                 2505             


Trp Ile  Asp Glu Pro Asp Val  Leu Val Met Ala Val  Lys Leu Leu 
    2510                 2515                 2520             


Ile Glu  Arg Ala Thr Asn Gln  Asp Trp Met Leu Arg  Val Lys Trp 
    2525                 2530                 2535             


Leu Tyr  His Leu Ala Lys Asn  Ile Pro Gln Gly Leu  Glu Ser Ile 
    2540                 2545                 2550             


Gln Ile  His Leu Glu Ala Ser  Ala Ala Ser Leu Arg  Asn Phe Tyr 
    2555                 2560                 2565             


Ser His  Ser Leu Ser Gly Ala  Val Ser Asn Val Phe  Lys Ile Leu 
    2570                 2575                 2580             


Gln Pro  Asn Thr Thr Asp Glu  Phe Val Ile Pro Leu  Asp Pro Arg 
    2585                 2590                 2595             


Trp Asn  Met Gln Ala Leu Asp  Met Ile Arg Asn Leu  Met Asp Phe 
    2600                 2605                 2610             


Asp Pro  Gln Thr Asp Gln Pro  Asp Gln Leu Phe Ala  Leu Leu Glu 
    2615                 2620                 2625             


Ser Ala  Ala Asn Lys Thr Ile  Ile Tyr Leu Asp Arg  Glu Lys Arg 
    2630                 2635                 2640             


Val Phe  Thr Glu Ala Asn Leu  Val Ser Val Gly Ser  Lys Lys Leu 
    2645                 2650                 2655             


Arg Glu  Ser Val Leu Arg Met  Ser Phe Glu Phe His  Gln Asp Pro 
    2660                 2665                 2670             


Glu Ser  Tyr His Thr Leu Pro  His Glu Ile Val Val  Asn Leu Ala 
    2675                 2680                 2685             


Ala Phe  Phe Glu Leu Cys Asp  Ala Leu Val Leu Leu  Trp Val Gln 
    2690                 2695                 2700             


Ser Ser  Gln Gly Met Val Ser  Asp Ala Ser Ala Asn  Glu Ile Leu 
    2705                 2710                 2715             


Gly Ser  Leu Arg Trp Arg Asp  Arg Phe Trp Thr Val  Ala Asp Thr 
    2720                 2725                 2730             


Val Lys  Val Asp Ala Pro Gly  Leu Ala Leu Leu Ala  Leu His Trp 
    2735                 2740                 2745             


His Trp  Val Leu Lys His Leu  Val His Gln Ile Pro  Arg Leu Leu 
    2750                 2755                 2760             


Met Asn  Tyr Glu Asp Lys Tyr  Tyr Lys Glu Val Gln  Thr Val Ser 
    2765                 2770                 2775             


Glu His  Ile Gln Asn Cys Leu  Gly Ser Gln Thr Gly  Gly Phe Ala 
    2780                 2785                 2790             


Gly Ile  Lys Lys Leu Gln Lys  Phe Leu Gly Arg Pro  Phe Pro Phe 
    2795                 2800                 2805             


Lys Asp  Lys Leu Val Val Glu  Cys Phe Ser Gln Leu  Lys Val Leu 
    2810                 2815                 2820             


Asn Lys  Val Leu Ala Ile Arg  Glu Gln Met Ser Ala  Leu Gly Glu 
    2825                 2830                 2835             


Ser Gly  Trp Gln Glu Asp Ile  Asn Arg Leu Gln Val  Val Ala Ser 
    2840                 2845                 2850             


Gln Trp  Thr Leu Lys Lys Ser  Leu Leu Gln Ala Trp  Gly Leu Ile 
    2855                 2860                 2865             


Leu Arg  Ala Asn Ile Leu Glu  Asp Val Ser Leu Asp  Glu Leu Lys 
    2870                 2875                 2880             


Asn Phe  Val His Ala Gln Cys  Leu Glu Leu Lys Ala  Lys Gly Leu 
    2885                 2890                 2895             


Ser Leu  Gly Phe Leu Glu Lys  Lys His Asp Glu Ala  Ser Ser Leu 
    2900                 2905                 2910             


Ser His  Pro Asp Leu Thr Ser  Val Ile His Leu Thr  Arg Ser Val 
    2915                 2920                 2925             


Gln Leu  Trp Pro Ala Met Glu  Tyr Leu Ala Met Leu  Trp Arg Tyr 
    2930                 2935                 2940             


Lys Val  Thr Ala Asp Phe Met  Ala Gln Ala Cys Leu  Arg Arg Cys 
    2945                 2950                 2955             


Ser Lys  Asn Gln Gln Pro Gln  Ile Asn Glu Glu Ile  Ser His Leu 
    2960                 2965                 2970             


Ile Ser  Phe Cys Leu Tyr His  Thr Pro Val Thr Pro  Gln Glu Leu 
    2975                 2980                 2985             


Arg Asp  Leu Trp Ser Leu Leu  His His Gln Lys Val  Ser Pro Glu 
    2990                 2995                 3000             


Glu Ile  Thr Ser Leu Trp Ser  Glu Leu Phe Asn Ser  Met Phe Met 
    3005                 3010                 3015             


Ser Phe  Trp Ser Ser Thr Val  Thr Thr Asn Pro Glu  Tyr Trp Leu 
    3020                 3025                 3030             


Met Trp  Asn Pro Leu Pro Gly  Met Gln Gln Arg Glu  Ala Pro Lys 
    3035                 3040                 3045             


Ser Val  Leu Asp Ser Thr Leu  Lys Gly Pro Gly Asn  Leu Asn Arg 
    3050                 3055                 3060             


Pro Ile  Phe Ser Lys Cys Cys  Phe Glu Val Leu Thr  Ser Ser Trp 
    3065                 3070                 3075             


Arg Ala  Ser Pro Trp Asp Val  Ser Gly Leu Pro Ile  Leu Ser Ser 
    3080                 3085                 3090             


Ser His  Val Thr Leu Gly Glu  Trp Val Glu Arg Thr  Gln Gln Leu 
    3095                 3100                 3105             


Gln Asp  Ile Ser Ser Met Leu  Trp Thr Asn Met Ala  Ile Ser Ser 
    3110                 3115                 3120             


Val Ala  Glu Phe Arg Arg Thr  Asp Ser Gln Leu Gln  Gly Gln Val 
    3125                 3130                 3135             


Leu Phe  Arg His Leu Ala Gly  Leu Ala Glu Leu Leu  Pro Glu Ser 
    3140                 3145                 3150             


Arg Arg  Gln Glu Tyr Met Gln  Asn Cys Glu Gln Leu  Leu Leu Gly 
    3155                 3160                 3165             


Ser Ser  Gln Ala Phe Gln His  Val Gly Gln Thr Leu  Gly Asp Met 
    3170                 3175                 3180             


Ala Gly  Gln Glu Val Leu Pro  Lys Glu Leu Leu Cys  Gln Leu Leu 
    3185                 3190                 3195             


Thr Ser  Leu His His Phe Val  Gly Glu Gly Glu Ser  Lys Arg Ser 
    3200                 3205                 3210             


Leu Pro  Glu Pro Ala Gln Arg  Gly Ser Leu Trp Val  Ser Leu Gly 
    3215                 3220                 3225             


Leu Leu  Gln Ile Gln Thr Trp  Leu Pro Gln Ala Arg  Phe Asp Pro 
    3230                 3235                 3240             


Ala Val  Lys Arg Glu Tyr Lys  Leu Asn Tyr Val Lys  Glu Glu Leu 
    3245                 3250                 3255             


His Gln  Leu Gln Cys Glu Trp  Lys Thr Arg Asn Leu  Ser Ser Gln 
    3260                 3265                 3270             


Leu Gln  Thr Gly Arg Asp Leu  Glu Asp Glu Val Val  Val Ser Tyr 
    3275                 3280                 3285             


Ser His  Pro His Val Arg Leu  Leu Arg Gln Arg Met  Asp Arg Leu 
    3290                 3295                 3300             


Asp Asn  Leu Thr Cys His Leu  Leu Lys Lys Gln Ala  Phe Arg Pro 
    3305                 3310                 3315             


Gln Leu  Pro Ala Tyr Glu Ser  Leu Val Gln Glu Ile  His His Tyr 
    3320                 3325                 3330             


Val Thr  Ser Ile Ala Lys Ala  Pro Ala Val Gln Asp  Leu Leu Thr 
    3335                 3340                 3345             


Arg Leu  Leu Gln Ala Leu His  Ile Asp Gly Pro Arg  Ser Ala Gln 
    3350                 3355                 3360             


Val Ala  Gln Ser Leu Leu Lys  Glu Glu Ala Ser Trp  Gln Gln Ser 
    3365                 3370                 3375             


His His  Gln Phe Arg Lys Arg  Leu Ser Glu Glu Tyr  Thr Phe Tyr 
    3380                 3385                 3390             


Pro Asp  Ala Val Ser Pro Leu  Gln Ala Ser Ile Leu  Gln Leu Gln 
    3395                 3400                 3405             


His Gly  Met Arg Leu Val Ala  Ser Glu Leu His Thr  Ser Leu His 
    3410                 3415                 3420             


Ser Ser  Met Val Gly Ala Asp  Arg Leu Gly Thr Leu  Ala Thr Ala 
    3425                 3430                 3435             


Leu Leu  Ala Phe Pro Ser Val  Gly Pro Thr Phe Pro  Thr Tyr Tyr 
    3440                 3445                 3450             


Ala His  Ala Asp Thr Leu Cys  Ser Val Lys Ser Glu  Glu Val Leu 
    3455                 3460                 3465             


Arg Gly  Leu Gly Lys Leu Ile  Leu Lys Arg Ser Gly  Gly Lys Glu 
    3470                 3475                 3480             


Leu Glu  Gly Lys Gly Gln Lys  Ala Cys Pro Thr Arg  Glu Gln Leu 
    3485                 3490                 3495             


Leu Met  Asn Ala Leu Leu Tyr  Leu Arg Ser His Val  Leu Cys Lys 
    3500                 3505                 3510             


Gly Glu  Leu Asp Gln Arg Ala  Leu Gln Leu Phe Arg  His Val Cys 
    3515                 3520                 3525             


Gln Glu  Ile Ile Ser Glu Trp  Asp Glu Gln Glu Arg  Ile Ala Gln 
    3530                 3535                 3540             


Glu Lys  Ala Glu Gln Glu Ser  Gly Leu Tyr Arg Tyr  Arg Ser Arg 
    3545                 3550                 3555             


Asn Ser  Arg Thr Ala Leu Ser  Glu Glu Glu Glu Glu  Glu Arg Glu 
    3560                 3565                 3570             


Phe Arg  Lys Gln Phe Pro Leu  His Glu Lys Asp Phe  Ala Asp Ile 
    3575                 3580                 3585             


Leu Val  Gln Pro Thr Leu Glu  Glu Asn Lys Gly Thr  Ser Asp Gly 
    3590                 3595                 3600             


Gln Glu  Glu Glu Ala Gly Thr  Asn Pro Ala Leu Leu  Ser Gln Asn 
    3605                 3610                 3615             


Ser Met  Gln Ala Val Met Leu  Ile His Gln Gln Leu  Cys Leu Asn 
    3620                 3625                 3630             


Phe Ala  Arg Ser Leu Trp Tyr  Gln Gln Thr Leu Pro  Pro His Glu 
    3635                 3640                 3645             


Ala Lys  His Tyr Leu Ser Leu  Phe Leu Ser Cys Tyr  Gln Thr Gly 
    3650                 3655                 3660             


Ala Ser  Leu Val Thr His Phe  Tyr Pro Leu Met Gly  Val Glu Leu 
    3665                 3670                 3675             


Asn Asp  Arg Leu Leu Gly Ser  Gln Leu Leu Ala Cys  Thr Leu Ser 
    3680                 3685                 3690             


His Asn  Thr Leu Phe Gly Glu  Ala Pro Ser Asp Leu  Met Val Lys 
    3695                 3700                 3705             


Pro Asp  Gly Pro Tyr Asp Phe  Tyr Gln His Pro Asn  Val Pro Glu 
    3710                 3715                 3720             


Ala Arg  Gln Cys Gln Pro Val  Leu Gln Gly Phe Ser  Glu Ala Val 
    3725                 3730                 3735             


Ser His  Leu Leu Gln Asp Trp  Pro Glu His Pro Ala  Leu Glu Gln 
    3740                 3745                 3750             


Leu Leu  Val Val Met Asp Arg  Ile Arg Ser Phe Pro  Leu Ser Ser 
    3755                 3760                 3765             


Pro Ile  Ser Lys Phe Leu Asn  Gly Leu Glu Ile Leu  Leu Ala Lys 
    3770                 3775                 3780             


Ala Gln  Asp Trp Glu Glu Asn  Ala Ser Arg Ala Leu  Ser Leu Arg 
    3785                 3790                 3795             


Lys His  Leu Asp Leu Ile Ser  Gln Met Ile Ile Arg  Trp Arg Lys 
    3800                 3805                 3810             


Leu Glu  Leu Asn Cys Trp Ser  Met Ser Leu Asp Asn  Thr Met Lys 
    3815                 3820                 3825             


Arg His  Thr Glu Lys Ser Thr  Lys His Trp Phe Ser  Ile Tyr Gln 
    3830                 3835                 3840             


Met Leu  Glu Lys His Met Gln  Glu Gln Thr Glu Glu  Gln Glu Asp 
    3845                 3850                 3855             


Asp Lys  Gln Met Thr Leu Met  Leu Leu Val Ser Thr  Leu Gln Ala 
    3860                 3865                 3870             


Phe Ile  Glu Gly Ser Ser Leu  Gly Glu Phe His Val  Arg Leu Gln 
    3875                 3880                 3885             


Met Leu  Leu Val Phe His Cys  His Val Leu Leu Met  Pro Gln Val 
    3890                 3895                 3900             


Glu Gly  Lys Asp Ser Leu Cys  Ser Val Leu Trp Asn  Leu Tyr His 
    3905                 3910                 3915             


Tyr Tyr  Lys Gln Phe Phe Asp  Arg Val Gln Ala Lys  Ile Val Glu 
    3920                 3925                 3930             


Leu Arg  Ser Pro Leu Glu Lys  Glu Leu Lys Glu Phe  Val Lys Ile 
    3935                 3940                 3945             


Ser Lys  Trp Asn Asp Val Ser  Phe Trp Ser Ile Lys  Gln Ser Val 
    3950                 3955                 3960             


Glu Lys  Thr His Arg Thr Leu  Phe Lys Phe Met Lys  Lys Phe Glu 
    3965                 3970                 3975             


Ala Val  Leu Ser Glu Pro Cys  Arg Ser Ser Leu Val  Glu Ser Asp 
    3980                 3985                 3990             


Lys Glu  Glu Gln Pro Asp Phe  Leu Pro Arg Pro Thr  Asp Gly Ala 
    3995                 4000                 4005             


Ala Ser  Glu Leu Ser Ser Ile  Gln Asn Leu Asn Arg  Ala Leu Arg 
    4010                 4015                 4020             


Glu Thr  Leu Leu Ala Gln Pro  Ala Ala Gly Gln Ala  Thr Ile Pro 
    4025                 4030                 4035             


Glu Trp  Cys Gln Gly Ala Ala  Pro Ser Gly Leu Glu  Gly Glu Leu 
    4040                 4045                 4050             


Leu Arg  Arg Leu Pro Lys Leu  Arg Lys Arg Met Arg  Lys Met Cys 
    4055                 4060                 4065             


Leu Thr  Phe Met Lys Glu Ser  Pro Leu Pro Arg Leu  Val Glu Gly 
    4070                 4075                 4080             


Leu Asp  Gln Phe Thr Gly Glu  Val Ile Ser Ser Val  Ser Glu Leu 
    4085                 4090                 4095             


Gln Ser  Leu Lys Val Glu Pro  Ser Ala Glu Lys Glu  Lys Gln Arg 
    4100                 4105                 4110             


Ser Glu  Ala Lys His Ile Leu  Met Gln Lys Gln Arg  Ala Leu Ser 
    4115                 4120                 4125             


Asp Leu  Phe Lys His Leu Ala  Lys Ile Gly Leu Ser  Tyr Arg Lys 
    4130                 4135                 4140             


Gly Leu  Ala Trp Ala Arg Ser  Lys Asn Pro Gln Glu  Met Leu His 
    4145                 4150                 4155             


Leu His  Pro Leu Asp Leu Gln  Ser Ala Leu Ser Ile  Val Ser Ser 
    4160                 4165                 4170             


Thr Gln  Glu Ala Asp Ser Arg  Leu Leu Thr Glu Ile  Ser Ser Ser 
    4175                 4180                 4185             


Trp Asp  Gly Cys Gln Lys Tyr  Phe Tyr Arg Ser Leu  Ala Arg His 
    4190                 4195                 4200             


Ala Arg  Leu Asn Ala Ala Leu  Ala Thr Pro Ala Lys  Glu Met Gly 
    4205                 4210                 4215             


Met Gly  Asn Val Glu Arg Cys  Arg Gly Phe Ser Ala  His Leu Met 
    4220                 4225                 4230             


Lys Met  Leu Val Arg Gln Arg  Arg Ser Leu Thr Thr  Leu Ser Glu 
    4235                 4240                 4245             


Gln Trp  Ile Ile Leu Arg Asn  Leu Leu Ser Cys Val  Gln Glu Ile 
    4250                 4255                 4260             


His Ser  Arg Leu Met Gly Pro  Gln Ala Tyr Pro Val  Ala Phe Pro 
    4265                 4270                 4275             


Pro Gln  Asp Gly Val Gln Gln  Trp Thr Glu Arg Leu  Gln His Leu 
    4280                 4285                 4290             


Ala Met  Gln Cys Gln Ile Leu  Leu Glu Gln Leu Ser  Trp Leu Leu 
    4295                 4300                 4305             


Gln Cys  Cys Pro Ser Val Gly  Pro Ala Pro Gly His  Gly Asn Val 
    4310                 4315                 4320             


Gln Val  Leu Gly Gln Pro Pro  Gly Pro Cys Leu Glu  Gly Pro Glu 
    4325                 4330                 4335             


Leu Ser  Lys Gly Gln Leu Cys  Gly Val Val Leu Asp  Leu Ile Pro 
    4340                 4345                 4350             


Ser Asn  Leu Ser Tyr Pro Ser  Pro Ile Pro Gly Ser  Gln Leu Pro 
    4355                 4360                 4365             


Ser Gly  Cys Arg Met Arg Lys  Gln Asp His Leu Trp  Gln Gln Ser 
    4370                 4375                 4380             


Thr Thr  Arg Leu Thr Glu Met  Leu Lys Thr Ile Lys  Thr Val Lys 
    4385                 4390                 4395             


Ala Asp  Val Asp Lys Ile Arg  Gln Gln Ser Cys Glu  Thr Leu Phe 
    4400                 4405                 4410             


His Ser  Trp Lys Asp Phe Glu  Val Cys Ser Ser Ala  Leu Ser Cys 
    4415                 4420                 4425             


Leu Ser  Gln Val Ser Val His  Leu Gln Gly Leu Glu  Ser Leu Phe 
    4430                 4435                 4440             


Ile Leu  Pro Gly Met Glu Val  Glu Gln Arg Asp Ser  Gln Met Ala 
    4445                 4450                 4455             


Leu Val  Glu Ser Leu Glu Tyr  Val Arg Gly Glu Ile  Ser Lys Ala 
    4460                 4465                 4470             


Met Ala  Asp Phe Thr Thr Trp  Lys Thr His Leu Leu  Thr Ser Asp 
    4475                 4480                 4485             


Ser Gln  Gly Gly Asn Gln Met  Leu Asp Glu Gly Phe  Val Glu Asp 
    4490                 4495                 4500             


Phe Ser  Glu Gln Met Glu Ile  Ala Ile Arg Ala Ile  Leu Cys Ala 
    4505                 4510                 4515             


Ile Gln  Asn Leu Glu Glu Arg  Lys Asn Glu Lys Ala  Glu Glu Asn 
    4520                 4525                 4530             


Thr Asp  Gln Ala Ser Pro Gln  Glu Asp Tyr Ala Gly  Phe Glu Arg 
    4535                 4540                 4545             


Leu Gln  Ser Gly His Leu Thr  Lys Leu Leu Glu Asp  Asp Phe Trp 
    4550                 4555                 4560             


Ala Asp  Val Ser Thr Leu His  Val Gln Lys Ile Ile  Ser Ala Ile 
    4565                 4570                 4575             


Ser Glu  Leu Leu Glu Arg Leu  Lys Ser Tyr Gly Glu  Asp Gly Thr 
    4580                 4585                 4590             


Ala Ala  Lys His Leu Phe Phe  Ser Gln Ser Cys Ser  Leu Leu Val 
    4595                 4600                 4605             


Arg Leu  Val Pro Val Leu Ser  Ser Tyr Ser Asp Leu  Val Leu Phe 
    4610                 4615                 4620             


Phe Leu  Thr Met Ser Leu Ala  Thr His Arg Ser Thr  Ala Lys Leu 
    4625                 4630                 4635             


Leu Ser  Val Leu Ala Gln Val  Phe Thr Glu Leu Ala  Gln Lys Gly 
    4640                 4645                 4650             


Phe Cys  Leu Pro Lys Glu Phe  Met Glu Asp Ser Ala  Gly Glu Gly 
    4655                 4660                 4665             


Ala Thr  Glu Phe His Asp Tyr  Glu Gly Gly Gly Ile  Gly Glu Gly 
    4670                 4675                 4680             


Glu Gly  Met Lys Asp Val Ser  Asp Gln Ile Gly Asn  Glu Glu Gln 
    4685                 4690                 4695             


Val Glu  Asp Thr Phe Gln Lys  Gly Gln Glu Lys Asp  Lys Glu Asp 
    4700                 4705                 4710             


Pro Asp  Ser Lys Ser Asp Ile  Lys Gly Glu Asp Asn  Ala Ile Glu 
    4715                 4720                 4725             


Met Ser  Glu Asp Phe Asp Gly  Lys Met His Asp Gly  Glu Leu Glu 
    4730                 4735                 4740             


Glu Gln  Glu Glu Asp Asp Glu  Lys Ser Asp Ser Glu  Gly Gly Asp 
    4745                 4750                 4755             


Leu Asp  Lys His Met Gly Asp  Leu Asn Gly Glu Glu  Ala Asp Lys 
    4760                 4765                 4770             


Leu Asp  Glu Arg Leu Trp Gly  Asp Asp Asp Glu Glu  Glu Asp Glu 
    4775                 4780                 4785             


Glu Glu  Glu Asp Asn Lys Thr  Glu Glu Thr Gly Pro  Gly Met Asp 
    4790                 4795                 4800             


Glu Glu  Asp Ser Glu Leu Val  Ala Lys Asp Asp Asn  Leu Asp Ser 
    4805                 4810                 4815             


Gly Asn  Ser Asn Lys Asp Lys  Ser Gln Gln Asp Lys  Lys Glu Glu 
    4820                 4825                 4830             


Lys Glu  Glu Ala Glu Ala Asp  Asp Gly Gly Gln Gly  Glu Asp Lys 
    4835                 4840                 4845             


Ile Asn  Glu Gln Ile Asp Glu  Arg Asp Tyr Asp Glu  Asn Glu Val 
    4850                 4855                 4860             


Asp Pro  Tyr His Gly Asn Gln  Glu Lys Val Pro Glu  Pro Glu Ala 
    4865                 4870                 4875             


Leu Asp  Leu Pro Asp Asp Leu  Asn Leu Asp Ser Glu  Asp Lys Asn 
    4880                 4885                 4890             


Gly Gly  Glu Asp Thr Asp Asn  Glu Glu Gly Glu Glu  Glu Asn Pro 
    4895                 4900                 4905             


Leu Glu  Ile Lys Glu Lys Pro  Glu Glu Ala Gly His  Glu Ala Glu 
    4910                 4915                 4920             


Glu Arg  Gly Glu Thr Glu Thr  Asp Gln Asn Glu Ser  Gln Ser Pro 
    4925                 4930                 4935             


Gln Glu  Pro Glu Glu Gly Pro  Ser Glu Asp Asp Lys  Ala Glu Gly 
    4940                 4945                 4950             


Glu Glu  Glu Met Asp Thr Gly  Ala Asp Asp Gln Asp  Gly Asp Ala 
    4955                 4960                 4965             


Ala Gln  His Pro Glu Glu His  Ser Glu Glu Gln Gln  Gln Ser Val 
    4970                 4975                 4980             


Glu Glu  Lys Asp Lys Glu Ala  Asp Glu Glu Gly Gly  Glu Asn Gly 
    4985                 4990                 4995             


Pro Ala  Asp Gln Gly Phe Gln  Pro Gln Glu Glu Glu  Glu Arg Glu 
    5000                 5005                 5010             


Asp Ser  Asp Thr Glu Glu Gln  Val Pro Glu Ala Leu  Glu Arg Lys 
    5015                 5020                 5025             


Glu His  Ala Ser Cys Gly Gln  Thr Gly Val Glu Asn  Met Gln Asn 
    5030                 5035                 5040             


Thr Gln  Ala Met Glu Leu Ala  Gly Ala Ala Pro Glu  Lys Glu Gln 
    5045                 5050                 5055             


Gly Lys  Glu Glu His Gly Ser  Gly Ala Ala Asp Ala  Asn Gln Ala 
    5060                 5065                 5070             


Glu Gly  His Glu Ser Asn Phe  Ile Ala Gln Leu Ala  Ser Gln Lys 
    5075                 5080                 5085             


His Thr  Arg Lys Asn Thr Gln  Ser Phe Lys Arg Lys  Pro Gly Gln 
    5090                 5095                 5100             


Ala Asp  Asn Glu Arg Ser Met  Gly Asp His Asn Glu  Arg Val His 
    5105                 5110                 5115             


Lys Arg  Leu Arg Thr Val Asp  Thr Asp Ser His Ala  Glu Gln Gly 
    5120                 5125                 5130             


Pro Ala  Gln Gln Pro Gln Ala  Gln Val Glu Asp Ala  Asp Ala Phe 
    5135                 5140                 5145             


Glu His  Ile Lys Gln Gly Ser  Asp Ala Tyr Asp Ala  Gln Thr Tyr 
    5150                 5155                 5160             


Asp Val  Ala Ser Lys Glu Gln  Gln Gln Ser Ala Lys  Asp Ser Gly 
    5165                 5170                 5175             


Lys Asp  Gln Glu Glu Glu Glu  Ile Glu Asp Thr Leu  Met Asp Thr 
    5180                 5185                 5190             


Glu Glu  Gln Glu Glu Phe Lys  Ala Ala Asp Val Glu  Gln Leu Lys 
    5195                 5200                 5205             


Pro Glu  Glu Ile Lys Ser Gly  Thr Thr Ala Pro Leu  Gly Phe Asp 
    5210                 5215                 5220             


Glu Met  Glu Val Glu Ile Gln  Thr Val Lys Thr Glu  Glu Asp Gln 
    5225                 5230                 5235             


Asp Pro  Arg Thr Asp Lys Ala  His Lys Glu Thr Glu  Asn Glu Lys 
    5240                 5245                 5250             


Pro Glu  Arg Ser Arg Glu Ser  Thr Ile His Thr Ala  His Gln Phe 
    5255                 5260                 5265             


Leu Met  Asp Thr Ile Phe Gln  Pro Phe Leu Lys Asp  Val Asn Glu 
    5270                 5275                 5280             


Leu Arg  Gln Glu Leu Glu Arg  Gln Leu Glu Met Trp  Gln Pro Arg 
    5285                 5290                 5295             


Glu Ser  Gly Asn Pro Glu Glu  Glu Lys Val Ala Ala  Glu Met Trp 
    5300                 5305                 5310             


Gln Ser  Tyr Leu Ile Leu Thr  Ala Pro Leu Ser Gln  Arg Leu Cys 
    5315                 5320                 5325             


Glu Glu  Leu Arg Leu Ile Leu  Glu Pro Thr Gln Ala  Ala Lys Leu 
    5330                 5335                 5340             


Lys Gly  Asp Tyr Arg Thr Gly  Lys Arg Leu Asn Ile  Arg Lys Val 
    5345                 5350                 5355             


Ile Pro  Tyr Ile Ala Ser Gln  Phe Arg Lys Asp Lys  Ile Trp Leu 
    5360                 5365                 5370             


Arg Arg  Thr Lys Pro Ser Lys  Arg Gln Tyr Gln Ile  Cys Leu Ala 
    5375                 5380                 5385             


Ile Asp  Asp Ser Ser Ser Met  Val Asp Asn His Thr  Lys Gln Leu 
    5390                 5395                 5400             


Ala Phe  Glu Ser Leu Ala Val  Ile Gly Asn Ala Leu  Thr Leu Leu 
    5405                 5410                 5415             


Glu Val  Gly Gln Ile Ala Val  Cys Ser Phe Gly Glu  Ser Val Lys 
    5420                 5425                 5430             


Leu Leu  His Pro Phe His Glu  Gln Phe Ser Asp Tyr  Ser Gly Ser 
    5435                 5440                 5445             


Gln Ile  Leu Arg Leu Cys Lys  Phe Gln Gln Lys Lys  Thr Lys Ile 
    5450                 5455                 5460             


Ala Gln  Phe Leu Glu Ser Val  Ala Asn Met Phe Ala  Ala Ala Gln 
    5465                 5470                 5475             


Gln Leu  Ser Gln Asn Ile Ser  Ser Glu Thr Ala Gln  Leu Leu Leu 
    5480                 5485                 5490             


Val Val  Ser Asp Gly Arg Gly  Leu Phe Leu Glu Gly  Lys Glu Arg 
    5495                 5500                 5505             


Val Leu  Ala Ala Val Gln Ala  Ala Arg Asn Ala Asn  Ile Phe Val 
    5510                 5515                 5520             


Ile Phe  Val Val Leu Asp Asn  Pro Ser Ser Arg Asp  Ser Ile Leu 
    5525                 5530                 5535             


Asp Ile  Lys Val Pro Ile Phe  Lys Gly Pro Gly Glu  Met Pro Glu 
    5540                 5545                 5550             


Ile Arg  Ser Tyr Met Glu Glu  Phe Pro Phe Pro Tyr  Tyr Ile Ile 
    5555                 5560                 5565             


Leu Arg  Asp Val Asn Ala Leu  Pro Glu Thr Leu Ser  Asp Ala Leu 
    5570                 5575                 5580             


Arg Gln  Trp Phe Glu Leu Val  Thr Ala Ser Asp His  Pro 
    5585                 5590                 5595     


<210>  186
<211>  1607
<212>  PRT
<213>  homo sapiens

<400>  186

Met Arg Glu Ala Ala Ala Ala Leu Val Pro Pro Pro Ala Phe Ala Val 
1               5                   10                  15      


Thr Pro Ala Ala Ala Met Glu Glu Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Pro Pro Glu Pro Glu Thr Glu Ser Glu Pro Glu Cys Cys Leu 
        35                  40                  45              


Ala Ala Arg Gln Glu Gly Thr Leu Gly Asp Ser Ala Cys Lys Ser Pro 
    50                  55                  60                  


Glu Ser Asp Leu Glu Asp Phe Ser Asp Glu Thr Asn Thr Glu Asn Leu 
65                  70                  75                  80  


Tyr Gly Thr Ser Pro Pro Ser Thr Pro Arg Gln Met Lys Arg Met Ser 
                85                  90                  95      


Thr Lys His Gln Arg Asn Asn Val Gly Arg Pro Ala Ser Arg Ser Asn 
            100                 105                 110         


Leu Lys Glu Lys Met Asn Ala Pro Asn Gln Pro Pro His Lys Asp Thr 
        115                 120                 125             


Gly Lys Thr Val Glu Asn Val Glu Glu Tyr Ser Tyr Lys Gln Glu Lys 
    130                 135                 140                 


Lys Ile Arg Ala Ala Leu Arg Thr Thr Glu Arg Asp His Lys Lys Asn 
145                 150                 155                 160 


Val Gln Cys Ser Phe Met Leu Asp Ser Val Gly Gly Ser Leu Pro Lys 
                165                 170                 175     


Lys Ser Ile Pro Asp Val Asp Leu Asn Lys Pro Tyr Leu Ser Leu Gly 
            180                 185                 190         


Cys Ser Asn Ala Lys Leu Pro Val Ser Val Pro Met Pro Ile Ala Arg 
        195                 200                 205             


Pro Ala Arg Gln Thr Ser Arg Thr Asp Cys Pro Ala Asp Arg Leu Lys 
    210                 215                 220                 


Phe Phe Glu Thr Leu Arg Leu Leu Leu Lys Leu Thr Ser Val Ser Lys 
225                 230                 235                 240 


Lys Lys Asp Arg Glu Gln Arg Gly Gln Glu Asn Thr Ser Gly Phe Trp 
                245                 250                 255     


Leu Asn Arg Ser Asn Glu Leu Ile Trp Leu Glu Leu Gln Ala Trp His 
            260                 265                 270         


Ala Gly Arg Thr Ile Asn Asp Gln Asp Phe Phe Leu Tyr Thr Ala Arg 
        275                 280                 285             


Gln Ala Ile Pro Asp Ile Ile Asn Glu Ile Leu Thr Phe Lys Val Asp 
    290                 295                 300                 


Tyr Gly Ser Phe Ala Phe Val Arg Asp Arg Ala Gly Phe Asn Gly Thr 
305                 310                 315                 320 


Ser Val Glu Gly Gln Cys Lys Ala Thr Pro Gly Thr Lys Ile Val Gly 
                325                 330                 335     


Tyr Ser Thr His His Glu His Leu Gln Arg Gln Arg Val Ser Phe Glu 
            340                 345                 350         


Gln Val Lys Arg Ile Met Glu Leu Leu Glu Tyr Ile Glu Ala Leu Tyr 
        355                 360                 365             


Pro Ser Leu Gln Ala Leu Gln Lys Asp Tyr Glu Lys Tyr Ala Ala Lys 
    370                 375                 380                 


Asp Phe Gln Asp Arg Val Gln Ala Leu Cys Leu Trp Leu Asn Ile Thr 
385                 390                 395                 400 


Lys Asp Leu Asn Gln Lys Leu Arg Ile Met Gly Thr Val Leu Gly Ile 
                405                 410                 415     


Lys Asn Leu Ser Asp Ile Gly Trp Pro Val Phe Glu Ile Pro Ser Pro 
            420                 425                 430         


Arg Pro Ser Lys Gly Asn Glu Pro Glu Tyr Glu Gly Asp Asp Thr Glu 
        435                 440                 445             


Gly Glu Leu Lys Glu Leu Glu Ser Ser Thr Asp Glu Ser Glu Glu Glu 
    450                 455                 460                 


Gln Ile Ser Asp Pro Arg Val Pro Glu Ile Arg Gln Pro Ile Asp Asn 
465                 470                 475                 480 


Ser Phe Asp Ile Gln Ser Arg Asp Cys Ile Ser Lys Lys Leu Glu Arg 
                485                 490                 495     


Leu Glu Ser Glu Asp Asp Ser Leu Gly Trp Gly Ala Pro Asp Trp Ser 
            500                 505                 510         


Thr Glu Ala Gly Phe Ser Arg His Cys Leu Thr Ser Ile Tyr Arg Pro 
        515                 520                 525             


Phe Val Asp Lys Ala Leu Lys Gln Met Gly Leu Arg Lys Leu Ile Leu 
    530                 535                 540                 


Arg Leu His Lys Leu Met Asp Gly Ser Leu Gln Arg Ala Arg Ile Ala 
545                 550                 555                 560 


Leu Val Lys Asn Asp Arg Pro Val Glu Phe Ser Glu Phe Pro Asp Pro 
                565                 570                 575     


Met Trp Gly Ser Asp Tyr Val Gln Leu Ser Arg Thr Pro Pro Ser Ser 
            580                 585                 590         


Glu Glu Lys Cys Ser Ala Val Ser Trp Glu Glu Leu Lys Ala Met Asp 
        595                 600                 605             


Leu Pro Ser Phe Glu Pro Ala Phe Leu Val Leu Cys Arg Val Leu Leu 
    610                 615                 620                 


Asn Val Ile His Glu Cys Leu Lys Leu Arg Leu Glu Gln Arg Pro Ala 
625                 630                 635                 640 


Gly Glu Pro Ser Leu Leu Ser Ile Lys Gln Leu Val Arg Glu Cys Lys 
                645                 650                 655     


Glu Val Leu Lys Gly Gly Leu Leu Met Lys Gln Tyr Tyr Gln Phe Met 
            660                 665                 670         


Leu Gln Glu Val Leu Glu Asp Leu Glu Lys Pro Asp Cys Asn Ile Asp 
        675                 680                 685             


Ala Phe Glu Glu Asp Leu His Lys Met Leu Met Val Tyr Phe Asp Tyr 
    690                 695                 700                 


Met Arg Ser Trp Ile Gln Met Leu Gln Gln Leu Pro Gln Ala Ser His 
705                 710                 715                 720 


Ser Leu Lys Asn Leu Leu Glu Glu Glu Trp Asn Phe Thr Lys Glu Ile 
                725                 730                 735     


Thr His Tyr Ile Arg Gly Gly Glu Ala Gln Ala Gly Lys Leu Phe Cys 
            740                 745                 750         


Asp Ile Ala Gly Met Leu Leu Lys Ser Thr Gly Ser Phe Leu Glu Phe 
        755                 760                 765             


Gly Leu Gln Glu Ser Cys Ala Glu Phe Trp Thr Ser Ala Asp Asp Ser 
    770                 775                 780                 


Ser Ala Ser Asp Glu Ile Ile Arg Ser Val Ile Glu Ile Ser Arg Ala 
785                 790                 795                 800 


Leu Lys Glu Leu Phe His Glu Ala Arg Glu Arg Ala Ser Lys Ala Leu 
                805                 810                 815     


Gly Phe Ala Lys Met Leu Arg Lys Asp Leu Glu Ile Ala Ala Glu Phe 
            820                 825                 830         


Arg Leu Ser Ala Pro Val Arg Asp Leu Leu Asp Val Leu Lys Ser Lys 
        835                 840                 845             


Gln Tyr Val Lys Val Gln Ile Pro Gly Leu Glu Asn Leu Gln Met Phe 
    850                 855                 860                 


Val Pro Asp Thr Leu Ala Glu Glu Lys Ser Ile Ile Leu Gln Leu Leu 
865                 870                 875                 880 


Asn Ala Ala Ala Gly Lys Asp Cys Ser Lys Asp Ser Asp Asp Val Leu 
                885                 890                 895     


Ile Asp Ala Tyr Leu Leu Leu Thr Lys His Gly Asp Arg Ala Arg Asp 
            900                 905                 910         


Ser Glu Asp Ser Trp Gly Thr Trp Glu Ala Gln Pro Val Lys Val Val 
        915                 920                 925             


Pro Gln Val Glu Thr Val Asp Thr Leu Arg Ser Met Gln Val Asp Asn 
    930                 935                 940                 


Leu Leu Leu Val Val Met Gln Ser Ala His Leu Thr Ile Gln Arg Lys 
945                 950                 955                 960 


Ala Phe Gln Gln Ser Ile Glu Gly Leu Met Thr Leu Cys Gln Glu Gln 
                965                 970                 975     


Thr Ser Ser Gln Pro Val Ile Ala Lys Ala Leu Gln Gln Leu Lys Asn 
            980                 985                 990         


Asp Ala Leu Glu Leu Cys Asn Arg  Ile Ser Asn Ala Ile  Asp Arg Val 
        995                 1000                 1005             


Asp His  Met Phe Thr Ser Glu  Phe Asp Ala Glu Val  Asp Glu Ser 
    1010                 1015                 1020             


Glu Ser  Val Thr Leu Gln Gln  Tyr Tyr Arg Glu Ala  Met Ile Gln 
    1025                 1030                 1035             


Gly Tyr  Asn Phe Gly Phe Glu  Tyr His Lys Glu Val  Val Arg Leu 
    1040                 1045                 1050             


Met Ser  Gly Glu Phe Arg Gln  Lys Ile Gly Asp Lys  Tyr Ile Ser 
    1055                 1060                 1065             


Phe Ala  Arg Lys Trp Met Asn  Tyr Val Leu Thr Lys  Cys Glu Ser 
    1070                 1075                 1080             


Gly Arg  Gly Thr Arg Pro Arg  Trp Ala Thr Gln Gly  Phe Asp Phe 
    1085                 1090                 1095             


Leu Gln  Ala Ile Glu Pro Ala  Phe Ile Ser Ala Leu  Pro Glu Asp 
    1100                 1105                 1110             


Asp Phe  Leu Ser Leu Gln Ala  Leu Met Asn Glu Cys  Ile Gly His 
    1115                 1120                 1125             


Val Ile  Gly Lys Pro His Ser  Pro Val Thr Gly Leu  Tyr Leu Ala 
    1130                 1135                 1140             


Ile His  Arg Asn Ser Pro Arg  Pro Met Lys Val Pro  Arg Cys His 
    1145                 1150                 1155             


Ser Asp  Pro Pro Asn Pro His  Leu Ile Ile Pro Thr  Pro Glu Gly 
    1160                 1165                 1170             


Phe Ser  Thr Arg Ser Met Pro  Ser Asp Ala Arg Ser  His Gly Ser 
    1175                 1180                 1185             


Pro Ala  Ala Ala Ala Ala Ala  Ala Ala Ala Val Ala  Ala Ser Arg 
    1190                 1195                 1200             


Pro Ser  Pro Ser Gly Gly Asp  Ser Val Leu Pro Lys  Ser Ile Ser 
    1205                 1210                 1215             


Ser Ala  His Asp Thr Arg Gly  Ser Ser Val Pro Glu  Asn Asp Arg 
    1220                 1225                 1230             


Leu Ala  Ser Ile Ala Ala Glu  Leu Gln Phe Arg Ser  Leu Ser Arg 
    1235                 1240                 1245             


His Ser  Ser Pro Thr Glu Glu  Arg Asp Glu Pro Ala  Tyr Pro Arg 
    1250                 1255                 1260             


Gly Asp  Ser Ser Gly Ser Thr  Arg Arg Ser Trp Glu  Leu Arg Thr 
    1265                 1270                 1275             


Leu Ile  Ser Gln Ser Lys Asp  Thr Ala Ser Lys Leu  Gly Pro Ile 
    1280                 1285                 1290             


Glu Ala  Ile Gln Lys Ser Val  Arg Leu Phe Glu Glu  Lys Arg Tyr 
    1295                 1300                 1305             


Arg Glu  Met Arg Arg Lys Asn  Ile Ile Gly Gln Val  Cys Asp Thr 
    1310                 1315                 1320             


Pro Lys  Ser Tyr Asp Asn Val  Met His Val Gly Leu  Arg Lys Val 
    1325                 1330                 1335             


Thr Phe  Lys Trp Gln Arg Gly  Asn Lys Ile Gly Glu  Gly Gln Tyr 
    1340                 1345                 1350             


Gly Lys  Val Tyr Thr Cys Ile  Ser Val Asp Thr Gly  Glu Leu Met 
    1355                 1360                 1365             


Ala Met  Lys Glu Ile Arg Phe  Gln Pro Asn Asp His  Lys Thr Ile 
    1370                 1375                 1380             


Lys Glu  Thr Ala Asp Glu Leu  Lys Ile Phe Glu Gly  Ile Lys His 
    1385                 1390                 1395             


Pro Asn  Leu Val Arg Tyr Phe  Gly Val Glu Leu His  Arg Glu Glu 
    1400                 1405                 1410             


Met Tyr  Ile Phe Met Glu Tyr  Cys Asp Glu Gly Thr  Leu Glu Glu 
    1415                 1420                 1425             


Val Ser  Arg Leu Gly Leu Gln  Glu His Val Ile Arg  Leu Tyr Ser 
    1430                 1435                 1440             


Lys Gln  Ile Thr Ile Ala Ile  Asn Val Leu His Glu  His Gly Ile 
    1445                 1450                 1455             


Val His  Arg Asp Ile Lys Gly  Ala Asn Ile Phe Leu  Thr Ser Ser 
    1460                 1465                 1470             


Gly Leu  Ile Lys Leu Gly Asp  Phe Gly Cys Ser Val  Lys Leu Lys 
    1475                 1480                 1485             


Asn Asn  Ala Gln Thr Met Pro  Gly Glu Val Asn Ser  Thr Leu Gly 
    1490                 1495                 1500             


Thr Ala  Ala Tyr Met Ala Pro  Glu Val Ile Thr Arg  Ala Lys Gly 
    1505                 1510                 1515             


Glu Gly  His Gly Arg Ala Ala  Asp Ile Trp Ser Leu  Gly Cys Val 
    1520                 1525                 1530             


Val Ile  Glu Met Val Thr Gly  Lys Arg Pro Trp His  Glu Tyr Glu 
    1535                 1540                 1545             


His Asn  Phe Gln Ile Met Tyr  Lys Val Gly Met Gly  His Lys Pro 
    1550                 1555                 1560             


Pro Ile  Pro Glu Arg Leu Ser  Pro Glu Gly Lys Asp  Phe Leu Ser 
    1565                 1570                 1575             


His Cys  Leu Glu Ser Asp Pro  Lys Met Arg Trp Thr  Ala Ser Gln 
    1580                 1585                 1590             


Leu Leu  Asp His Ser Phe Val  Lys Val Cys Thr Asp  Glu Glu 
    1595                 1600                 1605         


<210>  187
<211>  473
<212>  PRT
<213>  homo sapiens

<400>  187

Met Ser Thr Glu Leu Phe Ser Ser Thr Arg Glu Glu Gly Ser Ser Gly 
1               5                   10                  15      


Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu 
            20                  25                  30          


Leu Glu Arg Asp Thr Ser Phe Thr Val Cys Pro Asp Val Pro Arg Thr 
        35                  40                  45              


Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser 
    50                  55                  60                  


Gly Gly Thr Pro Lys Arg Cys Leu Asp Leu Ser Asn Leu Ser Ser Gly 
65                  70                  75                  80  


Glu Ile Thr Ala Thr Gln Leu Thr Thr Ser Ala Asp Leu Asp Glu Thr 
                85                  90                  95      


Gly His Leu Asp Ser Ser Gly Leu Gln Glu Val His Leu Ala Gly Met 
            100                 105                 110         


Asn His Asp Gln His Leu Met Lys Cys Ser Pro Ala Gln Leu Leu Cys 
        115                 120                 125             


Ser Thr Pro Asn Gly Leu Asp Arg Gly His Arg Lys Arg Asp Ala Met 
    130                 135                 140                 


Cys Ser Ser Ser Ala Asn Lys Glu Asn Asp Asn Gly Asn Leu Val Asp 
145                 150                 155                 160 


Ser Glu Met Lys Tyr Leu Gly Ser Pro Ile Thr Thr Val Pro Lys Leu 
                165                 170                 175     


Asp Lys Asn Pro Asn Leu Gly Glu Asp Gln Ala Glu Glu Ile Ser Asp 
            180                 185                 190         


Glu Leu Met Glu Phe Ser Leu Lys Asp Gln Glu Ala Lys Val Ser Arg 
        195                 200                 205             


Ser Gly Leu Tyr Arg Ser Pro Ser Met Pro Glu Asn Leu Asn Arg Pro 
    210                 215                 220                 


Arg Leu Lys Gln Val Glu Lys Phe Lys Asp Asn Thr Ile Pro Asp Lys 
225                 230                 235                 240 


Val Lys Lys Lys Tyr Phe Ser Gly Gln Gly Lys Leu Arg Lys Gly Leu 
                245                 250                 255     


Cys Leu Lys Lys Thr Val Ser Leu Cys Asp Ile Thr Ile Thr Gln Met 
            260                 265                 270         


Leu Glu Glu Asp Ser Asn Gln Gly His Leu Ile Gly Asp Phe Ser Lys 
        275                 280                 285             


Val Cys Ala Leu Pro Thr Val Ser Gly Lys His Gln Asp Leu Lys Tyr 
    290                 295                 300                 


Val Asn Pro Glu Thr Val Ala Ala Leu Leu Ser Gly Lys Phe Gln Gly 
305                 310                 315                 320 


Leu Ile Glu Lys Phe Tyr Val Ile Asp Cys Arg Tyr Pro Tyr Glu Tyr 
                325                 330                 335     


Leu Gly Gly His Ile Gln Gly Ala Leu Asn Leu Tyr Ser Gln Glu Glu 
            340                 345                 350         


Leu Phe Asn Phe Phe Leu Lys Lys Pro Ile Val Pro Leu Asp Thr Gln 
        355                 360                 365             


Lys Arg Ile Ile Ile Val Phe His Cys Glu Phe Ser Ser Glu Arg Gly 
    370                 375                 380                 


Pro Arg Met Cys Arg Cys Leu Arg Glu Glu Asp Arg Ser Leu Asn Gln 
385                 390                 395                 400 


Tyr Pro Ala Leu Tyr Tyr Pro Glu Leu Tyr Ile Leu Lys Gly Gly Tyr 
                405                 410                 415     


Arg Asp Phe Phe Pro Glu Tyr Met Glu Leu Cys Glu Pro Gln Ser Tyr 
            420                 425                 430         


Cys Pro Met His His Gln Asp His Lys Thr Glu Leu Leu Arg Cys Arg 
        435                 440                 445             


Ser Gln Ser Lys Val Gln Glu Gly Glu Arg Gln Leu Arg Glu Gln Ile 
    450                 455                 460                 


Ala Leu Leu Val Lys Asp Met Ser Pro 
465                 470             


<210>  188
<211>  6885
<212>  PRT
<213>  homo sapiens

<400>  188

Met Ala Ser Ser Pro Glu Leu Pro Thr Glu Asp Glu Gln Gly Ser Trp 
1               5                   10                  15      


Gly Ile Asp Asp Leu His Ile Ser Leu Gln Ala Glu Gln Glu Asp Thr 
            20                  25                  30          


Gln Lys Lys Ala Phe Thr Cys Trp Ile Asn Ser Gln Leu Ala Arg His 
        35                  40                  45              


Thr Ser Pro Ser Val Ile Ser Asp Leu Phe Thr Asp Ile Lys Lys Gly 
    50                  55                  60                  


His Val Leu Leu Asp Leu Leu Glu Val Leu Ser Gly Gln Gln Leu Pro 
65                  70                  75                  80  


Arg Asp Lys Gly Ser Asn Thr Phe Gln Cys Arg Ile Asn Ile Glu His 
                85                  90                  95      


Ala Leu Thr Phe Leu Arg Asn Arg Ser Ile Lys Leu Ile Asn Ile His 
            100                 105                 110         


Val Thr Asp Ile Ile Asp Gly Asn Pro Ser Ile Ile Leu Gly Leu Ile 
        115                 120                 125             


Trp Thr Ile Ile Leu His Phe His Ile Glu Lys Leu Ala Gln Thr Leu 
    130                 135                 140                 


Ser Cys Asn Tyr Asn Gln Pro Ser Leu Asp Asp Val Ser Val Val Asp 
145                 150                 155                 160 


Ser Ser Pro Ala Ser Ser Pro Pro Ala Lys Lys Cys Ser Lys Val Gln 
                165                 170                 175     


Ala Arg Trp Gln Met Ser Ala Arg Lys Ala Leu Leu Leu Trp Ala Gln 
            180                 185                 190         


Glu Gln Cys Ala Thr Tyr Glu Ser Val Asn Val Thr Asp Phe Lys Ser 
        195                 200                 205             


Ser Trp Arg Asn Gly Met Ala Phe Leu Ala Ile Ile His Ala Leu Arg 
    210                 215                 220                 


Pro Asp Leu Ile Asp Met Lys Ser Val Lys His Arg Ser Asn Lys Asp 
225                 230                 235                 240 


Asn Leu Arg Glu Ala Phe Arg Ile Ala Glu Gln Glu Leu Lys Ile Pro 
                245                 250                 255     


Arg Leu Leu Glu Pro Glu Asp Val Asp Val Val Asp Pro Asp Glu Lys 
            260                 265                 270         


Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Gln Tyr Ser Lys Asp Ala 
        275                 280                 285             


Pro Gly Thr Gly Glu Glu Ala Gln Gly Lys Val Lys Asp Ala Met Gly 
    290                 295                 300                 


Trp Leu Thr Leu Gln Lys Glu Lys Leu Gln Lys Leu Leu Lys Asp Ser 
305                 310                 315                 320 


Glu Asn Asp Thr Tyr Phe Lys Lys Tyr Asn Ser Leu Leu Ser Phe Met 
                325                 330                 335     


Glu Ser Phe Asn Glu Glu Lys Lys Ser Phe Leu Asp Val Leu Ser Ile 
            340                 345                 350         


Lys Arg Asp Leu Asp Glu Leu Asp Lys Asp His Leu Gln Leu Arg Glu 
        355                 360                 365             


Ala Trp Asp Gly Leu Asp His Gln Ile Asn Ala Trp Lys Ile Lys Leu 
    370                 375                 380                 


Asn Tyr Ala Leu Pro Pro Pro Leu His Gln Thr Glu Ala Trp Leu Gln 
385                 390                 395                 400 


Glu Val Glu Glu Leu Met Asp Glu Asp Leu Ser Ala Ser Gln Asp His 
                405                 410                 415     


Ser Gln Ala Val Thr Leu Ile Gln Glu Lys Met Thr Leu Phe Lys Ser 
            420                 425                 430         


Leu Met Asp Arg Phe Glu His His Ser Asn Ile Leu Leu Thr Phe Glu 
        435                 440                 445             


Asn Lys Asp Glu Asn His Leu Pro Leu Val Pro Pro Asn Lys Leu Glu 
    450                 455                 460                 


Glu Met Lys Arg Arg Ile Asn Asn Ile Leu Glu Lys Lys Phe Ile Leu 
465                 470                 475                 480 


Leu Leu Glu Phe His Tyr Tyr Lys Cys Leu Val Leu Gly Leu Val Asp 
                485                 490                 495     


Glu Val Lys Ser Lys Leu Asp Ile Trp Asn Ile Lys Tyr Gly Ser Arg 
            500                 505                 510         


Glu Ser Val Glu Leu Leu Leu Glu Asp Trp His Lys Phe Ile Glu Glu 
        515                 520                 525             


Lys Glu Phe Leu Ala Arg Leu Asp Thr Ser Phe Gln Lys Cys Gly Glu 
    530                 535                 540                 


Ile Tyr Lys Asn Leu Ala Gly Glu Cys Gln Asn Ile Asn Lys Gln Tyr 
545                 550                 555                 560 


Met Met Val Lys Ser Asp Val Cys Met Tyr Arg Lys Asn Ile Tyr Asn 
                565                 570                 575     


Val Lys Ser Thr Leu Gln Lys Val Leu Ala Cys Trp Ala Thr Tyr Val 
            580                 585                 590         


Glu Asn Leu Arg Leu Leu Arg Ala Cys Phe Glu Glu Thr Lys Lys Glu 
        595                 600                 605             


Glu Ile Lys Glu Val Pro Phe Glu Thr Leu Ala Gln Trp Asn Leu Glu 
    610                 615                 620                 


His Ala Thr Leu Asn Glu Ala Gly Asn Phe Leu Val Glu Val Ser Asn 
625                 630                 635                 640 


Asp Val Val Gly Ser Ser Ile Ser Lys Glu Leu Arg Arg Leu Asn Lys 
                645                 650                 655     


Arg Trp Arg Lys Leu Val Ser Lys Thr Gln Leu Glu Met Asn Leu Pro 
            660                 665                 670         


Leu Met Ile Lys Lys Gln Asp Gln Pro Thr Phe Asp Asn Ser Gly Asn 
        675                 680                 685             


Ile Leu Ser Lys Glu Glu Lys Ala Thr Val Glu Phe Ser Thr Asp Met 
    690                 695                 700                 


Ser Val Glu Leu Pro Glu Asn Tyr Asn Gln Asn Ile Lys Ala Gly Glu 
705                 710                 715                 720 


Lys His Glu Lys Glu Asn Glu Glu Phe Thr Gly Gln Leu Lys Val Ala 
                725                 730                 735     


Lys Asp Val Glu Lys Leu Ile Gly Gln Val Glu Ile Trp Glu Ala Glu 
            740                 745                 750         


Ala Lys Ser Val Leu Asp Gln Asp Asp Val Asp Thr Ser Met Glu Glu 
        755                 760                 765             


Ser Leu Lys His Leu Ile Ala Lys Gly Ser Met Phe Asp Glu Leu Met 
    770                 775                 780                 


Ala Arg Ser Glu Asp Met Leu Gln Met Asp Ile Gln Asn Ile Ser Ser 
785                 790                 795                 800 


Gln Glu Ser Phe Gln His Val Leu Thr Thr Gly Leu Gln Ala Lys Ile 
                805                 810                 815     


Gln Glu Ala Lys Glu Lys Val Gln Ile Asn Val Val Lys Leu Ile Ala 
            820                 825                 830         


Ala Leu Lys Asn Leu Thr Asp Val Ser Pro Asp Leu Asp Ile Arg Leu 
        835                 840                 845             


Lys Met Glu Glu Ser Gln Lys Glu Leu Glu Ser Tyr Met Met Arg Ala 
    850                 855                 860                 


Gln Gln Leu Leu Gly Gln Arg Glu Ser Pro Gly Glu Leu Ile Ser Lys 
865                 870                 875                 880 


His Lys Glu Ala Leu Ile Ile Ser Asn Thr Lys Ser Leu Ala Lys Tyr 
                885                 890                 895     


Leu Lys Ala Val Glu Glu Leu Lys Asn Asn Val Thr Glu Asp Ile Lys 
            900                 905                 910         


Met Ser Leu Glu Glu Lys Ser Arg Asp Val Cys Ala Lys Trp Glu Ser 
        915                 920                 925             


Leu His His Glu Leu Ser Leu Tyr Val Gln Gln Leu Lys Ile Asp Ile 
    930                 935                 940                 


Glu Lys Gly Lys Leu Ser Asp Asn Ile Leu Lys Leu Glu Lys Gln Ile 
945                 950                 955                 960 


Asn Lys Glu Lys Lys Leu Ile Arg Arg Gly Arg Thr Lys Gly Leu Ile 
                965                 970                 975     


Lys Glu His Glu Ala Cys Phe Ser Glu Glu Gly Cys Leu Tyr Gln Leu 
            980                 985                 990         


Asn His His Met Glu Val Leu Arg  Glu Leu Cys Glu Glu  Leu Pro Ser 
        995                 1000                 1005             


Gln Lys  Ser Gln Gln Glu Val  Lys Arg Leu Leu Lys  Asp Tyr Glu 
    1010                 1015                 1020             


Gln Lys  Ile Glu Arg Leu Leu  Lys Cys Ala Ser Glu  Ile His Met 
    1025                 1030                 1035             


Thr Leu  Gln Pro Thr Ala Gly  Gly Thr Ser Lys Asn  Glu Gly Thr 
    1040                 1045                 1050             


Ile Thr  Thr Ser Glu Asn Arg  Gly Gly Asp Pro His  Ser Glu Ala 
    1055                 1060                 1065             


Pro Phe  Ala Lys Ser Asp Asn  Gln Pro Ser Thr Glu  Lys Ala Met 
    1070                 1075                 1080             


Glu Pro  Thr Met Lys Phe Ser  Leu Ala Ser Val Leu  Arg Pro Leu 
    1085                 1090                 1095             


Gln Glu  Glu Ser Ile Met Glu  Lys Asp Tyr Ser Ala  Ser Ile Asn 
    1100                 1105                 1110             


Ser Leu  Leu Glu Arg Tyr Asp  Thr Tyr Arg Asp Ile  Leu Glu His 
    1115                 1120                 1125             


His Leu  Gln Asn Asn Lys Phe  Arg Ile Thr Ser Asp  Phe Ser Ser 
    1130                 1135                 1140             


Glu Glu  Asp Arg Ser Ser Ser  Cys Leu Gln Ala Lys  Leu Thr Asp 
    1145                 1150                 1155             


Leu Gln  Val Ile Lys Asn Glu  Thr Asp Ala Arg Trp  Lys Glu Phe 
    1160                 1165                 1170             


Glu Ile  Ile Ser Leu Lys Leu  Glu Asn His Val Asn  Asp Ile Lys 
    1175                 1180                 1185             


Lys Pro  Phe Val Ile Lys Glu  Arg Asp Thr Leu Lys  Glu Arg Glu 
    1190                 1195                 1200             


Arg Glu  Leu Gln Met Thr Leu  Asn Thr Arg Met Glu  Ser Leu Glu 
    1205                 1210                 1215             


Thr Ala  Leu Arg Leu Val Leu  Pro Val Glu Lys Ala  Ser Leu Leu 
    1220                 1225                 1230             


Leu Cys  Gly Ser Asp Leu Pro  Leu His Lys Met Ala  Ile Gln Gly 
    1235                 1240                 1245             


Phe His  Leu Ile Asp Ala Asp  Arg Ile Tyr Gln His  Leu Arg Asn 
    1250                 1255                 1260             


Ile Gln  Asp Ser Ile Ala Lys  Gln Ile Glu Ile Cys  Asn Arg Leu 
    1265                 1270                 1275             


Glu Glu  Pro Gly Asn Phe Val  Leu Lys Glu Leu His  Pro Phe Asp 
    1280                 1285                 1290             


Leu His  Ala Met Gln Asn Ile  Ile Leu Lys Tyr Lys  Thr Gln Phe 
    1295                 1300                 1305             


Glu Gly  Met Asn His Arg Val  Gln Arg Ser Glu Asp  Thr Leu Lys 
    1310                 1315                 1320             


Ala Leu  Glu Asp Phe Leu Ala  Ser Leu Arg Thr Ala  Lys Leu Ser 
    1325                 1330                 1335             


Ala Glu  Pro Val Thr Asp Leu  Ser Ala Ser Asp Thr  Gln Val Ala 
    1340                 1345                 1350             


Gln Glu  Asn Thr Leu Thr Val  Lys Asn Lys Glu Gly  Glu Ile His 
    1355                 1360                 1365             


Leu Met  Lys Asp Lys Ala Lys  His Leu Asp Lys Cys  Leu Lys Met 
    1370                 1375                 1380             


Leu Asp  Met Ser Phe Lys Asp  Ala Glu Arg Gly Asp  Asp Thr Ser 
    1385                 1390                 1395             


Cys Glu  Asn Leu Leu Asp Ala  Phe Ser Ile Lys Leu  Ser Glu Thr 
    1400                 1405                 1410             


His Gly  Tyr Gly Val Gln Glu  Glu Phe Thr Glu Glu  Asn Lys Leu 
    1415                 1420                 1425             


Leu Glu  Ala Cys Ile Phe Lys  Asn Asn Glu Leu Leu  Lys Asn Ile 
    1430                 1435                 1440             


Gln Asp  Val Gln Ser Gln Ile  Ser Lys Ile Gly Leu  Lys Asp Pro 
    1445                 1450                 1455             


Thr Val  Pro Ala Val Lys His  Arg Lys Lys Ser Leu  Ile Arg Leu 
    1460                 1465                 1470             


Asp Lys  Val Leu Asp Glu Tyr  Glu Glu Glu Lys Arg  His Leu Gln 
    1475                 1480                 1485             


Glu Met  Ala Asn Ser Leu Pro  His Phe Lys Asp Gly  Arg Glu Lys 
    1490                 1495                 1500             


Thr Val  Asn Gln Gln Cys Gln  Asn Thr Val Val Leu  Trp Glu Asn 
    1505                 1510                 1515             


Thr Lys  Ala Leu Val Thr Glu  Cys Leu Glu Gln Cys  Gly Arg Val 
    1520                 1525                 1530             


Leu Glu  Leu Leu Lys Gln Tyr  Gln Asn Phe Lys Ser  Ile Leu Thr 
    1535                 1540                 1545             


Thr Leu  Ile Gln Lys Glu Glu  Ser Val Ile Ser Leu  Gln Ala Ser 
    1550                 1555                 1560             


Tyr Met  Gly Lys Glu Asn Leu  Lys Lys Arg Ile Ala  Glu Ile Glu 
    1565                 1570                 1575             


Ile Val  Lys Glu Glu Phe Asn  Glu His Leu Glu Val  Val Asp Lys 
    1580                 1585                 1590             


Ile Asn  Gln Val Cys Lys Asn  Leu Gln Phe Tyr Leu  Asn Lys Met 
    1595                 1600                 1605             


Lys Thr  Phe Glu Glu Pro Pro  Phe Glu Lys Glu Ala  Asn Ile Ile 
    1610                 1615                 1620             


Val Asp  Arg Trp Leu Asp Ile  Asn Glu Lys Thr Glu  Asp Tyr Tyr 
    1625                 1630                 1635             


Glu Asn  Leu Gly Arg Ala Leu  Ala Leu Trp Asp Lys  Leu Phe Asn 
    1640                 1645                 1650             


Leu Lys  Asn Val Ile Asp Glu  Trp Thr Glu Lys Ala  Leu Gln Lys 
    1655                 1660                 1665             


Met Glu  Leu His Gln Leu Thr  Glu Glu Asp Arg Glu  Arg Leu Lys 
    1670                 1675                 1680             


Glu Glu  Leu Gln Val His Glu  Gln Lys Thr Ser Glu  Phe Ser Arg 
    1685                 1690                 1695             


Arg Val  Ala Glu Ile Gln Phe  Leu Leu Gln Ser Ser  Glu Ile Pro 
    1700                 1705                 1710             


Leu Glu  Leu Gln Val Met Glu  Ser Ser Ile Leu Asn  Lys Met Glu 
    1715                 1720                 1725             


His Val  Gln Lys Cys Leu Thr  Gly Glu Ser Asn Cys  His Ala Leu 
    1730                 1735                 1740             


Ser Gly  Ser Thr Ala Glu Leu  Arg Glu Asp Leu Asp  Gln Ala Lys 
    1745                 1750                 1755             


Thr Gln  Ile Gly Met Thr Glu  Ser Leu Leu Lys Ala  Leu Ser Pro 
    1760                 1765                 1770             


Ser Asp  Ser Leu Glu Ile Phe  Thr Lys Leu Glu Glu  Ile Gln Gln 
    1775                 1780                 1785             


Gln Ile  Leu Gln Gln Lys His  Ser Met Ile Leu Leu  Glu Asn Gln 
    1790                 1795                 1800             


Ile Gly  Cys Leu Thr Pro Glu  Leu Ser Glu Leu Lys  Lys Gln Tyr 
    1805                 1810                 1815             


Glu Ser  Val Ser Asp Leu Phe  Asn Thr Lys Lys Ser  Val Leu Gln 
    1820                 1825                 1830             


Asp His  Phe Ser Lys Leu Leu  Asn Asp Gln Cys Lys  Asn Phe Asn 
    1835                 1840                 1845             


Asp Trp  Phe Ser Asn Ile Lys  Val Asn Leu Lys Glu  Cys Phe Glu 
    1850                 1855                 1860             


Ser Ser  Glu Thr Lys Lys Ser  Val Glu Gln Lys Leu  Gln Lys Leu 
    1865                 1870                 1875             


Ser Asp  Phe Leu Thr Leu Glu  Gly Arg Asn Ser Lys  Ile Lys Gln 
    1880                 1885                 1890             


Val Asp  Ser Val Leu Lys His  Val Lys Lys His Leu  Pro Lys Ala 
    1895                 1900                 1905             


His Val  Lys Glu Leu Ile Ser  Trp Leu Val Gly Gln  Glu Phe Glu 
    1910                 1915                 1920             


Leu Glu  Lys Met Glu Ser Ile  Cys Gln Ala Arg Ala  Lys Glu Leu 
    1925                 1930                 1935             


Glu Asp  Ser Leu Gln Gln Leu  Leu Arg Leu Gln Asp  Asp His Arg 
    1940                 1945                 1950             


Asn Leu  Arg Lys Trp Leu Thr  Asn Gln Glu Glu Lys  Trp Lys Gly 
    1955                 1960                 1965             


Met Glu  Glu Pro Gly Glu Lys  Thr Glu Leu Phe Cys  Gln Ala Leu 
    1970                 1975                 1980             


Ala Arg  Lys Arg Glu Gln Phe  Glu Ser Val Ala Gln  Leu Asn Asn 
    1985                 1990                 1995             


Ser Leu  Lys Glu Tyr Gly Phe  Thr Glu Glu Glu Glu  Ile Ile Met 
    2000                 2005                 2010             


Glu Ala  Thr Cys Leu Met Asp  Arg Tyr Gln Thr Leu  Leu Arg Gln 
    2015                 2020                 2025             


Leu Ser  Glu Ile Glu Glu Glu  Asp Lys Leu Leu Pro  Thr Glu Asp 
    2030                 2035                 2040             


Gln Ser  Phe Asn Asp Leu Ala  His Asp Val Ile His  Trp Ile Lys 
    2045                 2050                 2055             


Glu Ile  Lys Glu Ser Leu Met  Val Leu Asn Ser Ser  Glu Gly Lys 
    2060                 2065                 2070             


Met Pro  Leu Glu Glu Arg Ile  Gln Lys Ile Lys Glu  Ile Ile Leu 
    2075                 2080                 2085             


Leu Lys  Pro Glu Gly Asp Ala  Arg Ile Glu Thr Ile  Met Lys Gln 
    2090                 2095                 2100             


Ala Glu  Ser Ser Glu Ala Pro  Leu Val Gln Lys Thr  Leu Thr Asp 
    2105                 2110                 2115             


Ile Ser  Asn Gln Trp Asp Asn  Thr Leu His Leu Ala  Ser Thr Tyr 
    2120                 2125                 2130             


Leu Ser  His Gln Glu Lys Leu  Leu Leu Glu Gly Glu  Lys Tyr Leu 
    2135                 2140                 2145             


Gln Ser  Lys Glu Asp Leu Arg  Leu Met Leu Ile Glu  Leu Lys Lys 
    2150                 2155                 2160             


Lys Gln  Glu Ala Gly Phe Ala  Leu Gln His Gly Leu  Gln Glu Lys 
    2165                 2170                 2175             


Lys Ala  Gln Leu Lys Ile Tyr  Lys Lys Phe Leu Lys  Lys Ala Gln 
    2180                 2185                 2190             


Asp Leu  Thr Ser Leu Leu Lys  Glu Leu Lys Ser Gln  Gly Asn Tyr 
    2195                 2200                 2205             


Leu Leu  Glu Cys Thr Lys Asn  Pro Ser Phe Ser Glu  Glu Pro Trp 
    2210                 2215                 2220             


Leu Glu  Ile Lys His Leu His  Glu Ser Leu Leu Gln  Gln Leu Gln 
    2225                 2230                 2235             


Asp Ser  Val Gln Asn Leu Asp  Gly His Val Arg Glu  His Asp Ser 
    2240                 2245                 2250             


Tyr Gln  Val Cys Val Thr Asp  Leu Asn Thr Thr Leu  Asp Asn Phe 
    2255                 2260                 2265             


Ser Lys  Glu Phe Val Ser Phe  Ser Asp Lys Pro Val  Asp Gln Ile 
    2270                 2275                 2280             


Ala Val  Glu Glu Lys Leu Gln  Lys Leu Gln Glu Leu  Glu Asn Arg 
    2285                 2290                 2295             


Leu Ser  Leu Gln Asp Gly Thr  Leu Lys Lys Ile Leu  Ala Leu Ala 
    2300                 2305                 2310             


Lys Ser  Val Lys Gln Asn Thr  Ser Ser Val Gly Gln  Lys Ile Ile 
    2315                 2320                 2325             


Lys Asp  Asp Ile Lys Ser Leu  Gln Cys Lys Gln Lys  Asp Leu Glu 
    2330                 2335                 2340             


Asn Arg  Leu Ala Ser Ala Lys  Gln Glu Met Glu Cys  Cys Leu Asn 
    2345                 2350                 2355             


Ser Ile  Leu Lys Ser Lys Arg  Ser Thr Glu Lys Lys  Gly Lys Phe 
    2360                 2365                 2370             


Thr Leu  Pro Gly Arg Glu Lys  Gln Ala Thr Ser Asp  Val Gln Glu 
    2375                 2380                 2385             


Ser Thr  Gln Glu Ser Ala Ala  Val Glu Lys Leu Glu  Glu Asp Trp 
    2390                 2395                 2400             


Glu Ile  Asn Lys Asp Ser Ala  Val Glu Met Ala Met  Ser Lys Gln 
    2405                 2410                 2415             


Leu Ser  Leu Asn Ala Gln Glu  Ser Met Lys Asn Thr  Glu Asp Glu 
    2420                 2425                 2430             


Arg Lys  Val Asn Glu Leu Gln  Asn Gln Pro Leu Glu  Leu Asp Thr 
    2435                 2440                 2445             


Met Leu  Arg Asn Glu Gln Leu  Glu Glu Ile Glu Lys  Leu Tyr Thr 
    2450                 2455                 2460             


Gln Leu  Glu Ala Lys Lys Ala  Ala Ile Lys Pro Leu  Glu Gln Thr 
    2465                 2470                 2475             


Glu Cys  Leu Asn Lys Thr Glu  Thr Gly Ala Leu Val  Leu His Asn 
    2480                 2485                 2490             


Ile Gly  Tyr Ser Ala Gln His  Leu Asp Asn Leu Leu  Gln Ala Leu 
    2495                 2500                 2505             


Ile Thr  Leu Lys Lys Asn Lys  Glu Ser Gln Tyr Cys  Val Leu Arg 
    2510                 2515                 2520             


Asp Phe  Gln Glu Tyr Leu Ala  Ala Val Glu Ser Ser  Met Lys Ala 
    2525                 2530                 2535             


Leu Leu  Thr Asp Lys Glu Ser  Leu Lys Val Gly Pro  Leu Asp Ser 
    2540                 2545                 2550             


Val Thr  Tyr Leu Asp Lys Ile  Lys Lys Phe Ile Ala  Ser Ile Glu 
    2555                 2560                 2565             


Lys Glu  Lys Asp Ser Leu Gly  Asn Leu Lys Ile Lys  Trp Glu Asn 
    2570                 2575                 2580             


Leu Ser  Asn His Val Thr Asp  Met Asp Lys Lys Leu  Leu Glu Ser 
    2585                 2590                 2595             


Gln Ile  Lys Gln Leu Glu His  Gly Trp Glu Gln Val  Glu Gln Gln 
    2600                 2605                 2610             


Ile Gln  Lys Lys Tyr Ser Gln  Gln Val Val Glu Tyr  Asp Glu Phe 
    2615                 2620                 2625             


Thr Thr  Leu Met Asn Lys Val  Gln Asp Thr Glu Ile  Ser Leu Gln 
    2630                 2635                 2640             


Gln Gln  Gln Gln His Leu Gln  Leu Arg Leu Lys Ser  Pro Glu Glu 
    2645                 2650                 2655             


Arg Ala  Gly Asn Gln Ser Met  Ile Ala Leu Thr Thr  Asp Leu Gln 
    2660                 2665                 2670             


Ala Thr  Lys His Gly Phe Ser  Val Leu Lys Gly Gln  Ala Glu Leu 
    2675                 2680                 2685             


Gln Met  Lys Arg Ile Trp Gly  Glu Lys Glu Lys Lys  Asn Leu Glu 
    2690                 2695                 2700             


Asp Gly  Ile Asn Asn Leu Lys  Lys Gln Trp Glu Thr  Leu Glu Pro 
    2705                 2710                 2715             


Leu His  Leu Glu Ala Glu Asn  Gln Ile Lys Lys Cys  Asp Ile Arg 
    2720                 2725                 2730             


Asn Lys  Met Lys Glu Thr Ile  Leu Trp Ala Lys Asn  Leu Leu Gly 
    2735                 2740                 2745             


Glu Leu  Asn Pro Ser Ile Pro  Leu Leu Pro Asp Asp  Ile Leu Ser 
    2750                 2755                 2760             


Gln Ile  Arg Lys Cys Lys Val  Thr His Asp Gly Ile  Leu Ala Arg 
    2765                 2770                 2775             


Gln Gln  Ser Val Glu Ser Leu  Ala Glu Glu Val Lys  Asp Lys Val 
    2780                 2785                 2790             


Pro Ser  Leu Thr Thr Tyr Glu  Gly Ser Asp Leu Asn  Asn Thr Leu 
    2795                 2800                 2805             


Glu Asp  Leu Arg Asn Gln Tyr  Gln Met Leu Val Leu  Lys Ser Thr 
    2810                 2815                 2820             


Gln Arg  Ser Gln Gln Leu Glu  Phe Lys Leu Glu Glu  Arg Ser Asn 
    2825                 2830                 2835             


Phe Phe  Ala Ile Ile Arg Lys  Phe Gln Leu Met Val  Gln Glu Ser 
    2840                 2845                 2850             


Glu Thr  Leu Ile Ile Pro Arg  Val Glu Thr Ala Ala  Thr Glu Ala 
    2855                 2860                 2865             


Glu Leu  Lys His His His Val  Thr Leu Glu Ala Ser  Gln Lys Glu 
    2870                 2875                 2880             


Leu Gln  Glu Ile Asp Ser Gly  Ile Ser Thr His Leu  Gln Glu Leu 
    2885                 2890                 2895             


Thr Asn  Ile Tyr Glu Glu Leu  Asn Val Phe Glu Arg  Leu Phe Leu 
    2900                 2905                 2910             


Glu Asp  Gln Leu Lys Asn Leu  Lys Ile Arg Thr Asn  Arg Ile Gln 
    2915                 2920                 2925             


Arg Phe  Ile Gln Asn Thr Cys  Asn Glu Val Glu His  Lys Ile Lys 
    2930                 2935                 2940             


Phe Cys  Arg Gln Phe His Glu  Lys Thr Ser Ala Leu  Gln Glu Glu 
    2945                 2950                 2955             


Ala Asp  Ser Ile Gln Arg Asn  Glu Leu Leu Leu Asn  Gln Glu Val 
    2960                 2965                 2970             


Asn Lys  Gly Val Lys Glu Glu  Ile Tyr Asn Leu Lys  Asp Arg Leu 
    2975                 2980                 2985             


Thr Ala  Ile Lys Cys Cys Ile  Leu Gln Val Leu Lys  Leu Lys Lys 
    2990                 2995                 3000             


Val Phe  Asp Tyr Ile Gly Leu  Asn Trp Asp Phe Ser  Gln Leu Asp 
    3005                 3010                 3015             


Gln Leu  Gln Thr Gln Val Phe  Glu Lys Glu Lys Glu  Leu Glu Glu 
    3020                 3025                 3030             


Lys Ile  Lys Gln Leu Asp Thr  Phe Glu Glu Glu His  Gly Lys Tyr 
    3035                 3040                 3045             


Gln Ala  Leu Leu Ser Lys Met  Arg Ala Ile Asp Leu  Gln Ile Lys 
    3050                 3055                 3060             


Lys Met  Thr Glu Val Val Leu  Lys Ala Pro Asp Ser  Ser Pro Glu 
    3065                 3070                 3075             


Ser Arg  Arg Leu Asn Ala Gln  Ile Leu Ser Gln Arg  Ile Glu Lys 
    3080                 3085                 3090             


Ala Lys  Cys Leu Cys Asp Glu  Ile Ile Lys Lys Leu  Asn Glu Asn 
    3095                 3100                 3105             


Lys Thr  Phe Asp Asp Ser Phe  Lys Glu Lys Glu Ile  Leu Gln Ile 
    3110                 3115                 3120             


Lys Leu  Asn Ala Glu Glu Asn  Asp Lys Leu Tyr Lys  Val Leu Gln 
    3125                 3130                 3135             


Asn Met  Val Leu Glu Leu Ser  Pro Lys Glu Leu Asp  Glu Lys Asn 
    3140                 3145                 3150             


Cys Gln  Asp Lys Leu Glu Thr  Ser Leu His Val Leu  Asn Gln Ile 
    3155                 3160                 3165             


Lys Ser  Gln Leu Gln Gln Pro  Leu Leu Ile Asn Leu  Glu Ile Lys 
    3170                 3175                 3180             


His Ile  Gln Asn Glu Lys Asp  Asn Cys Glu Ala Phe  Gln Glu Gln 
    3185                 3190                 3195             


Val Trp  Ala Glu Met Cys Ser  Ile Lys Ala Val Thr  Ala Ile Glu 
    3200                 3205                 3210             


Lys Gln  Arg Glu Glu Asn Ser  Ser Glu Ala Ser Asp  Val Glu Thr 
    3215                 3220                 3225             


Lys Leu  Arg Glu Phe Glu Asp  Leu Gln Met Gln Leu  Asn Thr Ser 
    3230                 3235                 3240             


Ile Asp  Leu Arg Thr Asn Val  Leu Asn Asp Ala Tyr  Glu Asn Leu 
    3245                 3250                 3255             


Thr Arg  Tyr Lys Glu Ala Val  Thr Arg Ala Val Glu  Ser Ile Thr 
    3260                 3265                 3270             


Ser Leu  Glu Ala Ile Ile Ile  Pro Tyr Arg Val Asp  Val Gly Asn 
    3275                 3280                 3285             


Pro Glu  Glu Ser Leu Glu Met  Pro Leu Arg Lys Gln  Glu Glu Leu 
    3290                 3295                 3300             


Glu Ser  Thr Val Ala His Ile  Gln Asp Leu Thr Glu  Lys Leu Gly 
    3305                 3310                 3315             


Met Ile  Ser Ser Pro Glu Ala  Lys Leu Gln Leu Gln  Tyr Thr Leu 
    3320                 3325                 3330             


Gln Glu  Leu Val Ser Lys Asn  Ser Ala Met Lys Glu  Ala Phe Lys 
    3335                 3340                 3345             


Ala Gln  Glu Thr Glu Ala Glu  Arg Tyr Leu Glu Asn  Tyr Lys Cys 
    3350                 3355                 3360             


Tyr Arg  Lys Met Glu Glu Asp  Ile Tyr Thr Asn Leu  Ser Lys Met 
    3365                 3370                 3375             


Glu Thr  Val Leu Gly Gln Ser  Met Ser Ser Leu Pro  Leu Ser Tyr 
    3380                 3385                 3390             


Arg Glu  Ala Leu Glu Arg Leu  Glu Gln Ser Lys Ala  Leu Val Ser 
    3395                 3400                 3405             


Asn Leu  Ile Ser Thr Lys Glu  Glu Leu Met Lys Leu  Arg Gln Ile 
    3410                 3415                 3420             


Leu Arg  Leu Leu Arg Leu Arg  Cys Thr Glu Asn Asp  Gly Ile Cys 
    3425                 3430                 3435             


Leu Leu  Lys Ile Val Ser Ala  Leu Trp Glu Lys Trp  Leu Ser Leu 
    3440                 3445                 3450             


Leu Glu  Ala Ala Lys Glu Trp  Glu Met Trp Cys Glu  Glu Leu Lys 
    3455                 3460                 3465             


Gln Glu  Trp Lys Phe Val Ser  Glu Glu Ile Glu Arg  Glu Ala Ile 
    3470                 3475                 3480             


Ile Leu  Asp Asn Leu Gln Glu  Glu Leu Pro Glu Ile  Ser Lys Thr 
    3485                 3490                 3495             


Lys Glu  Ala Ala Thr Thr Glu  Glu Leu Ser Glu Leu  Leu Asp Cys 
    3500                 3505                 3510             


Leu Cys  Gln Tyr Gly Glu Asn  Val Glu Lys Gln Gln  Leu Leu Leu 
    3515                 3520                 3525             


Thr Leu  Leu Leu Gln Arg Ile  Arg Ser Ile Gln Asn  Val Pro Glu 
    3530                 3535                 3540             


Ser Ser  Gly Ala Val Glu Thr  Val Pro Ala Phe Gln  Glu Ile Thr 
    3545                 3550                 3555             


Ser Met  Lys Glu Arg Cys Asn  Lys Leu Leu Gln Lys  Val Gln Lys 
    3560                 3565                 3570             


Asn Lys  Glu Leu Val Gln Thr  Glu Ile Gln Glu Arg  His Ser Phe 
    3575                 3580                 3585             


Thr Lys  Glu Ile Ile Ala Leu  Lys Asn Phe Phe Gln  Gln Thr Thr 
    3590                 3595                 3600             


Thr Ser  Phe Gln Asn Met Ala  Phe Gln Asp His Pro  Glu Lys Ser 
    3605                 3610                 3615             


Glu Gln  Phe Glu Glu Leu Gln  Ser Ile Leu Lys Lys  Gly Lys Leu 
    3620                 3625                 3630             


Thr Phe  Glu Asn Ile Met Glu  Lys Leu Arg Ile Lys  Tyr Ser Glu 
    3635                 3640                 3645             


Met Tyr  Thr Ile Val Pro Ala  Glu Ile Glu Ser Gln  Val Glu Glu 
    3650                 3655                 3660             


Cys Arg  Lys Ala Leu Glu Asp  Ile Asp Glu Lys Ile  Ser Asn Glu 
    3665                 3670                 3675             


Val Leu  Lys Ser Ser Pro Ser  Tyr Ala Met Arg Arg  Lys Ile Glu 
    3680                 3685                 3690             


Glu Ile  Asn Asn Gly Leu His  Asn Val Glu Lys Met  Leu Gln Gln 
    3695                 3700                 3705             


Lys Ser  Lys Asn Ile Glu Lys  Ala Gln Glu Ile Gln  Lys Lys Met 
    3710                 3715                 3720             


Trp Asp  Glu Leu Asp Leu Trp  His Ser Lys Leu Asn  Glu Leu Asp 
    3725                 3730                 3735             


Ser Glu  Val Gln Asp Ile Val  Glu Gln Asp Pro Gly  Gln Ala Gln 
    3740                 3745                 3750             


Glu Trp  Met Asp Asn Leu Met  Ile Pro Phe Gln Gln  Tyr Gln Gln 
    3755                 3760                 3765             


Val Ser  Gln Arg Ala Glu Cys  Arg Thr Ser Gln Leu  Asn Lys Ala 
    3770                 3775                 3780             


Thr Val  Lys Met Glu Glu Tyr  Ser Asp Leu Leu Lys  Ser Thr Glu 
    3785                 3790                 3795             


Ala Trp  Ile Glu Asn Thr Ser  His Leu Leu Ala Asn  Pro Ala Asp 
    3800                 3805                 3810             


Tyr Asp  Ser Leu Arg Thr Leu  Ser His His Ala Ser  Thr Val Gln 
    3815                 3820                 3825             


Met Ala  Leu Glu Asp Ser Glu  Gln Lys His Asn Leu  Leu His Ser 
    3830                 3835                 3840             


Ile Phe  Met Asp Leu Glu Asp  Leu Ser Ile Ile Phe  Glu Thr Asp 
    3845                 3850                 3855             


Glu Leu  Thr Gln Ser Ile Gln  Glu Leu Ser Asn Gln  Val Thr Ala 
    3860                 3865                 3870             


Leu Gln  Gln Lys Ile Met Glu  Ser Leu Pro Gln Ile  Gln Arg Met 
    3875                 3880                 3885             


Ala Asp  Asp Val Val Ala Ile  Glu Ser Glu Val Lys  Ser Met Glu 
    3890                 3895                 3900             


Lys Arg  Val Ser Lys Ile Lys  Thr Ile Leu Leu Ser  Lys Glu Ile 
    3905                 3910                 3915             


Phe Asp  Phe Ser Pro Glu Glu  His Leu Lys His Gly  Glu Val Ile 
    3920                 3925                 3930             


Leu Glu  Asn Ile Arg Pro Met  Lys Lys Thr Ile Ala  Glu Ile Val 
    3935                 3940                 3945             


Ser Tyr  Gln Val Glu Leu Arg  Leu Pro Gln Thr Gly  Met Lys Pro 
    3950                 3955                 3960             


Leu Pro  Val Phe Gln Arg Thr  Asn Gln Leu Leu Gln  Asp Ile Lys 
    3965                 3970                 3975             


Leu Leu  Glu Asn Val Thr Gln  Glu Gln Asn Glu Leu  Leu Lys Val 
    3980                 3985                 3990             


Val Ile  Lys Gln Thr Asn Glu  Trp Asp Glu Glu Ile  Glu Asn Leu 
    3995                 4000                 4005             


Lys Gln  Ile Leu Asn Asn Tyr  Ser Ala Gln Phe Ser  Leu Glu His 
    4010                 4015                 4020             


Met Ser  Pro Asp Gln Ala Asp  Lys Leu Pro Gln Leu  Gln Gly Glu 
    4025                 4030                 4035             


Ile Glu  Arg Met Glu Lys Gln  Ile Leu Ser Leu Asn  Gln Arg Lys 
    4040                 4045                 4050             


Glu Asp  Leu Leu Val Asp Leu  Lys Ala Thr Val Leu  Asn Leu His 
    4055                 4060                 4065             


Gln His  Leu Lys Gln Glu Gln  Glu Gly Val Glu Arg  Asp Arg Leu 
    4070                 4075                 4080             


Pro Ala  Val Thr Ser Glu Glu  Gly Gly Val Ala Glu  Arg Asp Ala 
    4085                 4090                 4095             


Ser Glu  Arg Lys Leu Asn Arg  Arg Gly Ser Met Ser  Tyr Leu Ala 
    4100                 4105                 4110             


Ala Val  Glu Glu Glu Val Glu  Glu Ser Ser Val Lys  Ser Asp Asn 
    4115                 4120                 4125             


Gly Asp  Glu Lys Ala Glu Pro  Ser Pro Gln Ser Trp  Ser Ser Leu 
    4130                 4135                 4140             


Trp Lys  His Asp Lys Asp Met  Glu Glu Asp Arg Ala  Ser Ser Ser 
    4145                 4150                 4155             


Ser Gly  Thr Ile Val Gln Glu  Ala Tyr Gly Lys Ile  Ser Thr Ser 
    4160                 4165                 4170             


Asp Asn  Ser Met Ala Gln Ile  Leu Thr Pro Asp Ser  Leu Asn Thr 
    4175                 4180                 4185             


Glu Gln  Gly Pro Glu Cys Ser  Leu Arg Pro Asn Gln  Thr Glu Glu 
    4190                 4195                 4200             


Gly Thr  Thr Pro Pro Ile Glu  Ala Asp Thr Leu Asp  Ser Ser Asp 
    4205                 4210                 4215             


Ala Gln  Gly Gly Leu Glu Pro  Arg Val Glu Lys Thr  Arg Pro Glu 
    4220                 4225                 4230             


Pro Thr  Glu Val Leu His Ala  Cys Lys Thr Gln Val  Ala Glu Leu 
    4235                 4240                 4245             


Glu Leu  Trp Leu Gln Gln Ala  Asn Val Ala Val Glu  Pro Glu Thr 
    4250                 4255                 4260             


Leu Asn  Ala Asp Met Gln Gln  Val Leu Glu Gln Gln  Leu Val Gly 
    4265                 4270                 4275             


Cys Gln  Ala Met Leu Thr Glu  Ile Glu His Lys Val  Ala Phe Leu 
    4280                 4285                 4290             


Leu Glu  Thr Cys Lys Asp Gln  Gly Leu Gly Asp Asn  Gly Ala Thr 
    4295                 4300                 4305             


Gln His  Glu Ala Glu Ala Leu  Ser Leu Lys Leu Lys  Thr Val Lys 
    4310                 4315                 4320             


Cys Asn  Leu Glu Lys Val Gln  Met Met Leu Gln Glu  Lys His Ser 
    4325                 4330                 4335             


Glu Asp  Gln His Pro Thr Ile  Leu Lys Lys Ser Ser  Glu Pro Glu 
    4340                 4345                 4350             


His Gln  Glu Ala Leu Gln Pro  Val Asn Leu Ser Glu  Leu Glu Ser 
    4355                 4360                 4365             


Ile Val  Thr Glu Arg Pro Gln  Phe Ser Arg Gln Lys  Asp Phe Gln 
    4370                 4375                 4380             


Gln Gln  Gln Val Leu Glu Leu  Lys Pro Met Glu Gln  Lys Asp Phe 
    4385                 4390                 4395             


Ile Lys  Phe Ile Glu Phe Asn  Ala Lys Lys Met Trp  Pro Gln Tyr 
    4400                 4405                 4410             


Cys Gln  His Asp Asn Asp Thr  Thr Gln Glu Ser Ser  Ala Ser Asn 
    4415                 4420                 4425             


Gln Ala  Ser Ser Pro Glu Asn  Asp Val Pro Asp Ser  Ile Leu Ser 
    4430                 4435                 4440             


Pro Gln  Gly Gln Asn Gly Asp  Lys Trp Gln Tyr Leu  His His Glu 
    4445                 4450                 4455             


Leu Ser  Ser Lys Ile Lys Leu  Pro Leu Pro Gln Leu  Val Glu Pro 
    4460                 4465                 4470             


Gln Val  Ser Thr Asn Met Gly  Ile Leu Pro Ser Val  Thr Met Tyr 
    4475                 4480                 4485             


Asn Phe  Arg Tyr Pro Thr Thr  Glu Glu Leu Lys Thr  Tyr Thr Thr 
    4490                 4495                 4500             


Gln Leu  Glu Asp Leu Arg Gln  Glu Ala Ser Asn Leu  Gln Thr Gln 
    4505                 4510                 4515             


Glu Asn  Met Thr Glu Glu Ala  Tyr Ile Asn Leu Asp  Lys Lys Leu 
    4520                 4525                 4530             


Phe Glu  Leu Phe Leu Thr Leu  Ser Gln Cys Leu Ser  Ser Val Glu 
    4535                 4540                 4545             


Glu Met  Leu Glu Met Pro Arg  Leu Tyr Arg Glu Asp  Gly Ser Gly 
    4550                 4555                 4560             


Gln Gln  Val His Tyr Glu Thr  Leu Ala Leu Glu Leu  Lys Lys Leu 
    4565                 4570                 4575             


Tyr Leu  Ala Leu Ser Asp Lys  Lys Gly Asp Leu Leu  Lys Ala Met 
    4580                 4585                 4590             


Thr Trp  Pro Gly Glu Asn Thr  Asn Leu Leu Leu Glu  Cys Phe Asp 
    4595                 4600                 4605             


Asn Leu  Gln Val Cys Leu Glu  His Thr Gln Ala Ala  Ala Val Cys 
    4610                 4615                 4620             


Arg Ser  Lys Ser Leu Lys Ala  Gly Leu Asp Tyr Asn  Arg Ser Tyr 
    4625                 4630                 4635             


Gln Asn  Glu Ile Lys Arg Leu  Tyr His Gln Leu Ile  Lys Ser Lys 
    4640                 4645                 4650             


Thr Ser  Leu Gln Gln Ser Leu  Asn Glu Ile Ser Gly  Gln Ser Val 
    4655                 4660                 4665             


Ala Glu  Gln Leu Gln Lys Ala  Asp Ala Tyr Thr Val  Glu Leu Glu 
    4670                 4675                 4680             


Asn Ala  Glu Ser Arg Val Ala  Lys Leu Arg Asp Glu  Gly Glu Arg 
    4685                 4690                 4695             


Leu His  Leu Pro Tyr Ala Leu  Leu Gln Glu Val Tyr  Lys Leu Glu 
    4700                 4705                 4710             


Asp Val  Leu Asp Ser Met Trp  Gly Met Leu Arg Ala  Arg Tyr Thr 
    4715                 4720                 4725             


Glu Leu  Ser Ser Pro Phe Val  Thr Glu Ser Gln Gln  Asp Ala Leu 
    4730                 4735                 4740             


Leu Gln  Gly Met Val Glu Leu  Val Lys Ile Gly Lys  Glu Lys Leu 
    4745                 4750                 4755             


Ala His  Gly His Leu Lys Gln  Thr Lys Ser Lys Val  Ala Leu Gln 
    4760                 4765                 4770             


Ala Gln  Ile Glu Asn His Lys  Val Phe Phe Gln Lys  Leu Val Ala 
    4775                 4780                 4785             


Asp Met  Leu Leu Ile Gln Ala  Tyr Ser Ala Lys Ile  Leu Pro Ser 
    4790                 4795                 4800             


Leu Leu  Gln Asn Arg Glu Thr  Phe Trp Ala Glu Gln  Val Thr Glu 
    4805                 4810                 4815             


Val Lys  Ile Leu Glu Glu Lys  Ser Arg Gln Cys Gly  Met Lys Leu 
    4820                 4825                 4830             


Gln Ser  Leu Leu Gln Lys Trp  Glu Glu Phe Asp Glu  Asn Tyr Ala 
    4835                 4840                 4845             


Ser Leu  Glu Lys Asp Leu Glu  Ile Leu Ile Ser Thr  Leu Pro Ser 
    4850                 4855                 4860             


Val Ser  Leu Val Glu Glu Thr  Glu Glu Arg Leu Val  Glu Arg Ile 
    4865                 4870                 4875             


Ser Phe  Tyr Gln Gln Ile Lys  Arg Asn Ile Gly Gly  Lys His Ala 
    4880                 4885                 4890             


Arg Leu  Tyr Gln Thr Leu Asn  Glu Gly Lys Gln Leu  Val Ala Ser 
    4895                 4900                 4905             


Val Ser  Cys Pro Glu Leu Glu  Gly Gln Ile Ala Lys  Leu Glu Glu 
    4910                 4915                 4920             


Gln Trp  Leu Ser Leu Asn Lys  Lys Ile Asp His Glu  Leu His Arg 
    4925                 4930                 4935             


Leu Gln  Ala Leu Leu Lys His  Leu Leu Ser Tyr Asn  Arg Asp Ser 
    4940                 4945                 4950             


Asp Gln  Leu Thr Lys Trp Leu  Glu Ser Ser Gln His  Thr Leu Asn 
    4955                 4960                 4965             


Tyr Trp  Lys Glu Gln Ser Leu  Asn Val Ser Gln Asp  Leu Asp Thr 
    4970                 4975                 4980             


Ile Arg  Ser Asn Ile Asn Asn  Phe Phe Glu Phe Ser  Lys Glu Val 
    4985                 4990                 4995             


Asp Glu  Lys Ser Ser Leu Lys  Thr Ala Val Ile Ser  Ile Gly Asn 
    5000                 5005                 5010             


Gln Leu  Leu His Leu Lys Glu  Thr Asp Thr Ala Thr  Leu Arg Ala 
    5015                 5020                 5025             


Ser Leu  Ala Gln Phe Glu Gln  Lys Trp Thr Met Leu  Ile Thr Gln 
    5030                 5035                 5040             


Leu Pro  Asp Ile Gln Glu Lys  Leu His Gln Leu Gln  Met Glu Lys 
    5045                 5050                 5055             


Leu Pro  Ser Arg Lys Ala Ile  Thr Glu Met Ile Ser  Trp Met Asn 
    5060                 5065                 5070             


Asn Val  Glu His Gln Thr Ser  Asp Glu Asp Ser Val  His Ser Pro 
    5075                 5080                 5085             


Ser Ser  Ala Ser Gln Val Lys  His Leu Leu Gln Lys  His Lys Glu 
    5090                 5095                 5100             


Phe Arg  Met Glu Met Asp Tyr  Lys Gln Trp Ile Val  Asp Phe Val 
    5105                 5110                 5115             


Asn Gln  Ser Leu Leu Gln Leu  Ser Thr Cys Asp Val  Glu Ser Lys 
    5120                 5125                 5130             


Arg Tyr  Glu Arg Thr Glu Phe  Ala Glu His Leu Gly  Glu Met Asn 
    5135                 5140                 5145             


Arg Gln  Trp His Arg Val His  Gly Met Leu Asn Arg  Lys Ile Gln 
    5150                 5155                 5160             


His Leu  Glu Gln Leu Leu Glu  Ser Ile Thr Glu Ser  Glu Asn Lys 
    5165                 5170                 5175             


Ile Gln  Ile Leu Asn Asn Trp  Leu Glu Ala Gln Glu  Glu Arg Leu 
    5180                 5185                 5190             


Lys Thr  Leu Gln Lys Pro Glu  Ser Val Ile Ser Val  Gln Lys Leu 
    5195                 5200                 5205             


Leu Leu  Asp Cys Gln Asp Ile  Glu Asn Gln Leu Ala  Ile Lys Ser 
    5210                 5215                 5220             


Lys Ala  Leu Asp Glu Leu Lys  Gln Ser Tyr Leu Thr  Leu Glu Ser 
    5225                 5230                 5235             


Gly Ala  Val Pro Leu Leu Glu  Asp Thr Ala Ser Arg  Ile Asp Glu 
    5240                 5245                 5250             


Leu Phe  Gln Lys Arg Ser Ser  Val Leu Thr Gln Val  Asn Gln Leu 
    5255                 5260                 5265             


Lys Thr  Ser Met Gln Ser Val  Leu Gln Glu Trp Lys  Ile Tyr Asp 
    5270                 5275                 5280             


Gln Leu  Tyr Asp Glu Val Asn  Met Met Thr Ile Arg  Phe Trp Tyr 
    5285                 5290                 5295             


Cys Met  Glu His Ser Lys Pro  Val Val Leu Ser Leu  Glu Thr Leu 
    5300                 5305                 5310             


Arg Cys  Gln Val Glu Asn Leu  Gln Ser Leu Gln Asp  Glu Ala Glu 
    5315                 5320                 5325             


Ser Ser  Glu Gly Ser Trp Glu  Lys Leu Gln Glu Val  Ile Gly Lys 
    5330                 5335                 5340             


Leu Lys  Gly Leu Cys Pro Ser  Val Ala Glu Ile Ile  Glu Glu Lys 
    5345                 5350                 5355             


Cys Gln  Asn Thr His Lys Arg  Trp Thr Gln Val Asn  Gln Ala Ile 
    5360                 5365                 5370             


Ala Asp  Gln Leu Gln Lys Ala  Gln Ser Leu Leu Gln  Leu Trp Lys 
    5375                 5380                 5385             


Ala Tyr  Ser Asn Ala His Gly  Glu Ala Ala Ala Arg  Leu Lys Gln 
    5390                 5395                 5400             


Gln Glu  Ala Lys Phe Gln Gln  Leu Ala Asn Ile Ser  Met Ser Gly 
    5405                 5410                 5415             


Asn Asn  Leu Ala Glu Ile Leu  Pro Pro Ala Leu Gln  Asp Ile Lys 
    5420                 5425                 5430             


Glu Leu  Gln His Asp Val Gln  Lys Thr Lys Glu Ala  Phe Leu Gln 
    5435                 5440                 5445             


Asn Ser  Ser Val Leu Asp Arg  Leu Pro Gln Pro Ala  Glu Ser Ser 
    5450                 5455                 5460             


Thr His  Met Leu Leu Pro Gly  Pro Leu His Ser Leu  Gln Arg Ala 
    5465                 5470                 5475             


Ala Tyr  Leu Glu Lys Met Leu  Leu Val Lys Ala Asn  Glu Phe Glu 
    5480                 5485                 5490             


Phe Val  Leu Ser Gln Phe Lys  Asp Phe Gly Val Arg  Leu Glu Ser 
    5495                 5500                 5505             


Leu Lys  Gly Leu Ile Met His  Glu Glu Glu Asn Leu  Asp Arg Leu 
    5510                 5515                 5520             


His Gln  Gln Glu Lys Glu Asn  Pro Asp Ser Phe Leu  Asn His Val 
    5525                 5530                 5535             


Leu Ala  Leu Thr Ala Gln Ser  Pro Asp Ile Glu His  Leu Asn Glu 
    5540                 5545                 5550             


Val Ser  Leu Lys Leu Pro Leu  Ser Asp Val Ala Val  Lys Thr Leu 
    5555                 5560                 5565             


Gln Asn  Met Asn Arg Gln Trp  Ile Arg Ala Thr Ala  Thr Ala Leu 
    5570                 5575                 5580             


Glu Arg  Cys Ser Glu Leu Gln  Gly Ile Gly Leu Asn  Glu Lys Phe 
    5585                 5590                 5595             


Leu Tyr  Cys Cys Glu Lys Trp  Ile Gln Leu Leu Glu  Lys Ile Glu 
    5600                 5605                 5610             


Glu Ala  Leu Lys Val Asp Val  Ala Asn Ser Leu Pro  Glu Leu Leu 
    5615                 5620                 5625             


Glu Gln  Gln Lys Thr Tyr Lys  Met Leu Glu Ala Glu  Val Ser Ile 
    5630                 5635                 5640             


Asn Gln  Thr Ile Ala Asp Ser  Tyr Val Thr Gln Ser  Leu Gln Leu 
    5645                 5650                 5655             


Leu Asp  Thr Thr Glu Ile Glu  Asn Arg Pro Glu Phe  Ile Thr Glu 
    5660                 5665                 5670             


Phe Ser  Lys Leu Thr Asp Arg  Trp Gln Asn Ala Val  Gln Gly Val 
    5675                 5680                 5685             


Arg Gln  Arg Lys Gly Asp Val  Asp Gly Leu Val Arg  Gln Trp Gln 
    5690                 5695                 5700             


Asp Phe  Thr Thr Ser Val Glu  Asn Leu Phe Arg Phe  Leu Thr Asp 
    5705                 5710                 5715             


Thr Ser  His Leu Leu Ser Ala  Val Lys Gly Gln Glu  Arg Phe Ser 
    5720                 5725                 5730             


Leu Tyr  Gln Thr Arg Ser Leu  Ile His Glu Leu Lys  Asn Lys Glu 
    5735                 5740                 5745             


Ile His  Phe Gln Arg Arg Arg  Thr Thr Cys Ala Leu  Thr Leu Glu 
    5750                 5755                 5760             


Ala Gly  Glu Lys Leu Leu Leu  Thr Thr Asp Leu Lys  Thr Lys Glu 
    5765                 5770                 5775             


Ser Val  Gly Arg Arg Ile Ser  Gln Leu Gln Asp Ser  Trp Lys Asp 
    5780                 5785                 5790             


Met Glu  Pro Gln Leu Ala Glu  Met Ile Lys Gln Phe  Gln Ser Thr 
    5795                 5800                 5805             


Val Glu  Thr Trp Asp Gln Cys  Glu Lys Lys Ile Lys  Glu Leu Lys 
    5810                 5815                 5820             


Ser Arg  Leu Gln Val Leu Lys  Ala Gln Ser Glu Asp  Pro Leu Pro 
    5825                 5830                 5835             


Glu Leu  His Glu Asp Leu His  Asn Glu Lys Glu Leu  Ile Lys Glu 
    5840                 5845                 5850             


Leu Glu  Gln Ser Leu Ala Ser  Trp Thr Gln Asn Leu  Lys Glu Leu 
    5855                 5860                 5865             


Gln Thr  Met Lys Ala Asp Leu  Thr Arg His Val Leu  Val Glu Asp 
    5870                 5875                 5880             


Val Met  Val Leu Lys Glu Gln  Ile Glu His Leu His  Arg Gln Trp 
    5885                 5890                 5895             


Glu Asp  Leu Cys Leu Arg Val  Ala Ile Arg Lys Gln  Glu Ile Glu 
    5900                 5905                 5910             


Asp Arg  Leu Asn Thr Trp Val  Val Phe Asn Glu Lys  Asn Lys Glu 
    5915                 5920                 5925             


Leu Cys  Ala Trp Leu Val Gln  Met Glu Asn Lys Val  Leu Gln Thr 
    5930                 5935                 5940             


Ala Asp  Ile Ser Ile Glu Glu  Met Ile Glu Lys Leu  Gln Lys Asp 
    5945                 5950                 5955             


Cys Met  Glu Glu Ile Asn Leu  Phe Ser Glu Asn Lys  Leu Gln Leu 
    5960                 5965                 5970             


Lys Gln  Met Gly Asp Gln Leu  Ile Lys Ala Ser Asn  Lys Ser Arg 
    5975                 5980                 5985             


Ala Ala  Glu Ile Asp Asp Lys  Leu Asn Lys Ile Asn  Asp Arg Trp 
    5990                 5995                 6000             


Gln His  Leu Phe Asp Val Ile  Gly Ser Arg Val Lys  Lys Leu Lys 
    6005                 6010                 6015             


Glu Thr  Phe Ala Phe Ile Gln  Gln Leu Asp Lys Asn  Met Ser Asn 
    6020                 6025                 6030             


Leu Arg  Thr Trp Leu Ala Arg  Ile Glu Ser Glu Leu  Ser Lys Pro 
    6035                 6040                 6045             


Val Val  Tyr Asp Val Cys Asp  Asp Gln Glu Ile Gln  Lys Arg Leu 
    6050                 6055                 6060             


Ala Glu  Gln Gln Asp Leu Gln  Arg Asp Ile Glu Gln  His Ser Ala 
    6065                 6070                 6075             


Gly Val  Glu Ser Val Phe Asn  Ile Cys Asp Val Leu  Leu His Asp 
    6080                 6085                 6090             


Ser Asp  Ala Cys Ala Asn Glu  Thr Glu Cys Asp Ser  Ile Gln Gln 
    6095                 6100                 6105             


Thr Thr  Arg Ser Leu Asp Arg  Arg Trp Arg Asn Ile  Cys Ala Met 
    6110                 6115                 6120             


Ser Met  Glu Arg Arg Met Lys  Ile Glu Glu Thr Trp  Arg Leu Trp 
    6125                 6130                 6135             


Gln Lys  Phe Leu Asp Asp Tyr  Ser Arg Phe Glu Asp  Trp Leu Lys 
    6140                 6145                 6150             


Ser Ala  Glu Arg Thr Ala Ala  Cys Pro Asn Ser Ser  Glu Val Leu 
    6155                 6160                 6165             


Tyr Thr  Ser Ala Lys Glu Glu  Leu Lys Arg Phe Glu  Ala Phe Gln 
    6170                 6175                 6180             


Arg Gln  Ile His Glu Arg Leu  Thr Gln Leu Glu Leu  Ile Asn Lys 
    6185                 6190                 6195             


Gln Tyr  Arg Arg Leu Ala Arg  Glu Asn Arg Thr Asp  Thr Ala Ser 
    6200                 6205                 6210             


Arg Leu  Lys Gln Met Val His  Glu Gly Asn Gln Arg  Trp Asp Asn 
    6215                 6220                 6225             


Leu Gln  Arg Arg Val Thr Ala  Val Leu Arg Arg Leu  Arg His Phe 
    6230                 6235                 6240             


Thr Asn  Gln Arg Glu Glu Phe  Glu Gly Thr Arg Glu  Ser Ile Leu 
    6245                 6250                 6255             


Val Trp  Leu Thr Glu Met Asp  Leu Gln Leu Thr Asn  Val Glu His 
    6260                 6265                 6270             


Phe Ser  Glu Ser Asp Ala Asp  Asp Lys Met Arg Gln  Leu Asn Gly 
    6275                 6280                 6285             


Phe Gln  Gln Glu Ile Thr Leu  Asn Thr Asn Lys Ile  Asp Gln Leu 
    6290                 6295                 6300             


Ile Val  Phe Gly Glu Gln Leu  Ile Gln Lys Ser Glu  Pro Leu Asp 
    6305                 6310                 6315             


Ala Val  Leu Ile Glu Asp Glu  Leu Glu Glu Leu His  Arg Tyr Cys 
    6320                 6325                 6330             


Gln Glu  Val Phe Gly Arg Val  Ser Arg Phe His Arg  Arg Leu Thr 
    6335                 6340                 6345             


Ser Cys  Thr Pro Gly Leu Glu  Asp Glu Lys Glu Ala  Ser Glu Asn 
    6350                 6355                 6360             


Glu Thr  Asp Met Glu Asp Pro  Arg Glu Ile Gln Thr  Asp Ser Trp 
    6365                 6370                 6375             


Arg Lys  Arg Gly Glu Ser Glu  Glu Pro Ser Ser Pro  Gln Ser Leu 
    6380                 6385                 6390             


Cys His  Leu Val Ala Pro Gly  His Glu Arg Ser Gly  Cys Glu Thr 
    6395                 6400                 6405             


Pro Val  Ser Val Asp Ser Ile  Pro Leu Glu Trp Asp  His Thr Gly 
    6410                 6415                 6420             


Asp Val  Gly Gly Ser Ser Ser  His Glu Glu Asp Glu  Glu Gly Pro 
    6425                 6430                 6435             


Tyr Tyr  Ser Ala Leu Ser Gly  Lys Ser Ile Ser Asp  Gly His Ser 
    6440                 6445                 6450             


Trp His  Val Pro Asp Ser Pro  Ser Cys Pro Glu His  His Tyr Lys 
    6455                 6460                 6465             


Gln Met  Glu Gly Asp Arg Asn  Val Pro Pro Val Pro  Pro Ala Ser 
    6470                 6475                 6480             


Ser Thr  Pro Tyr Lys Pro Pro  Tyr Gly Lys Leu Leu  Leu Pro Pro 
    6485                 6490                 6495             


Gly Thr  Asp Gly Gly Lys Glu  Gly Pro Arg Val Leu  Asn Gly Asn 
    6500                 6505                 6510             


Pro Gln  Gln Glu Asp Gly Gly  Leu Ala Gly Ile Thr  Glu Gln Gln 
    6515                 6520                 6525             


Ser Gly  Ala Phe Asp Arg Trp  Glu Met Ile Gln Ala  Gln Glu Leu 
    6530                 6535                 6540             


His Asn  Lys Leu Lys Ile Lys  Gln Asn Leu Gln Gln  Leu Asn Ser 
    6545                 6550                 6555             


Asp Ile  Ser Ala Ile Thr Thr  Trp Leu Lys Lys Thr  Glu Ala Glu 
    6560                 6565                 6570             


Leu Glu  Met Leu Lys Met Ala  Lys Pro Pro Ser Asp  Ile Gln Glu 
    6575                 6580                 6585             


Ile Glu  Leu Arg Val Lys Arg  Leu Gln Glu Ile Leu  Lys Ala Phe 
    6590                 6595                 6600             


Asp Thr  Tyr Lys Ala Leu Val  Val Ser Val Asn Val  Ser Ser Lys 
    6605                 6610                 6615             


Glu Phe  Leu Gln Thr Glu Ser  Pro Glu Ser Thr Glu  Leu Gln Ser 
    6620                 6625                 6630             


Arg Leu  Arg Gln Leu Ser Leu  Leu Trp Glu Ala Ala  Gln Gly Ala 
    6635                 6640                 6645             


Val Asp  Ser Trp Arg Gly Gly  Leu Arg Gln Ser Leu  Met Gln Cys 
    6650                 6655                 6660             


Gln Asp  Phe His Gln Leu Ser  Gln Asn Leu Leu Leu  Trp Leu Ala 
    6665                 6670                 6675             


Ser Ala  Lys Asn Arg Arg Gln  Lys Ala His Val Thr  Asp Pro Lys 
    6680                 6685                 6690             


Ala Asp  Pro Arg Ala Leu Leu  Glu Cys Arg Arg Glu  Leu Met Gln 
    6695                 6700                 6705             


Leu Glu  Lys Glu Leu Val Glu  Arg Gln Pro Gln Val  Asp Met Leu 
    6710                 6715                 6720             


Gln Glu  Ile Ser Asn Ser Leu  Leu Ile Lys Gly His  Gly Glu Asp 
    6725                 6730                 6735             


Cys Ile  Glu Ala Glu Glu Lys  Val His Val Ile Glu  Lys Lys Leu 
    6740                 6745                 6750             


Lys Gln  Leu Arg Glu Gln Val  Ser Gln Asp Leu Met  Ala Leu Gln 
    6755                 6760                 6765             


Gly Thr  Gln Asn Pro Ala Ser  Pro Leu Pro Ser Phe  Asp Glu Val 
    6770                 6775                 6780             


Asp Ser  Gly Asp Gln Pro Pro  Ala Thr Ser Val Pro  Ala Pro Arg 
    6785                 6790                 6795             


Ala Lys  Gln Phe Arg Ala Val  Arg Thr Thr Glu Gly  Glu Glu Glu 
    6800                 6805                 6810             


Thr Glu  Ser Arg Val Pro Gly  Ser Thr Arg Pro Gln  Arg Ser Phe 
    6815                 6820                 6825             


Leu Ser  Arg Val Val Arg Ala  Ala Leu Pro Leu Gln  Leu Leu Leu 
    6830                 6835                 6840             


Leu Leu  Leu Leu Leu Leu Ala  Cys Leu Leu Pro Ser  Ser Glu Glu 
    6845                 6850                 6855             


Asp Tyr  Ser Cys Thr Gln Ala  Asn Asn Phe Ala Arg  Ser Phe Tyr 
    6860                 6865                 6870             


Pro Met  Leu Arg Tyr Thr Asn  Gly Pro Pro Pro Thr  
    6875                 6880                 6885 


<210>  189
<211>  2960
<212>  PRT
<213>  homo sapiens

<400>  189

Met Pro Gly Ile Lys Val Gly Gly Ser Gly Val Asn Val Asn Ala Lys 
1               5                   10                  15      


Gly Leu Asp Leu Gly Gly Arg Gly Gly Val Gln Val Pro Ala Val Asp 
            20                  25                  30          


Ile Ser Ser Ser Leu Gly Gly Arg Pro Val Glu Val Gln Gly Pro Ser 
        35                  40                  45              


Leu Glu Ser Gly Asp His Ala Lys Ile Lys Phe Pro Thr Met Lys Val 
    50                  55                  60                  


Pro Lys Phe Gly Val Ser Thr Gly Arg Glu Gly Gln Thr Pro Lys Ala 
65                  70                  75                  80  


Gly Leu Arg Val Ser Ala Pro Glu Val Ser Val Gly His Lys Gly Gly 
                85                  90                  95      


Lys Pro Gly Leu Thr Ile Gln Ala Pro Gln Leu Glu Val Ser Val Pro 
            100                 105                 110         


Ser Ala Asn Ile Glu Gly Leu Glu Gly Lys Leu Lys Gly Pro Gln Ile 
        115                 120                 125             


Thr Gly Pro Ser Leu Glu Gly Asp Leu Gly Leu Lys Gly Ala Lys Pro 
    130                 135                 140                 


Gln Gly His Ile Gly Val Asp Ala Ser Ala Pro Gln Ile Gly Gly Ser 
145                 150                 155                 160 


Ile Thr Gly Pro Ser Val Glu Val Gln Ala Pro Asp Ile Asp Val Gln 
                165                 170                 175     


Gly Pro Gly Ser Lys Leu Asn Val Pro Lys Met Lys Val Pro Lys Phe 
            180                 185                 190         


Ser Val Ser Gly Ala Lys Gly Glu Glu Thr Gly Ile Asp Val Thr Leu 
        195                 200                 205             


Pro Thr Gly Glu Val Thr Val Pro Gly Val Ser Gly Asp Val Ser Leu 
    210                 215                 220                 


Pro Glu Ile Ala Thr Gly Gly Leu Glu Gly Lys Met Lys Gly Thr Lys 
225                 230                 235                 240 


Val Lys Thr Pro Glu Met Ile Ile Gln Lys Pro Lys Ile Ser Met Gln 
                245                 250                 255     


Asp Val Asp Leu Ser Leu Gly Ser Pro Lys Leu Lys Gly Asp Ile Lys 
            260                 265                 270         


Val Ser Ala Pro Gly Val Gln Gly Asp Val Lys Gly Pro Gln Val Ala 
        275                 280                 285             


Leu Lys Gly Ser Arg Val Asp Ile Glu Thr Pro Asn Leu Glu Gly Thr 
    290                 295                 300                 


Leu Thr Gly Pro Arg Leu Gly Ser Pro Ser Gly Lys Thr Gly Thr Cys 
305                 310                 315                 320 


Arg Ile Ser Met Ser Glu Val Asp Leu Asn Val Ala Ala Pro Lys Val 
                325                 330                 335     


Lys Gly Gly Val Asp Val Thr Leu Pro Arg Val Glu Gly Lys Val Lys 
            340                 345                 350         


Val Pro Glu Val Asp Val Arg Gly Pro Lys Val Asp Val Ser Ala Pro 
        355                 360                 365             


Asp Val Glu Ala His Gly Pro Glu Trp Asn Leu Lys Met Pro Lys Met 
    370                 375                 380                 


Lys Met Pro Thr Phe Ser Thr Pro Gly Ala Lys Gly Glu Gly Pro Asp 
385                 390                 395                 400 


Val His Met Thr Leu Pro Lys Gly Asp Ile Ser Ile Ser Gly Pro Lys 
                405                 410                 415     


Val Asn Val Glu Ala Pro Asp Val Asn Leu Glu Gly Leu Gly Gly Lys 
            420                 425                 430         


Leu Lys Gly Pro Asp Val Lys Leu Pro Asp Met Ser Val Lys Thr Pro 
        435                 440                 445             


Lys Ile Ser Met Pro Asp Val Asp Leu His Val Lys Gly Thr Lys Val 
    450                 455                 460                 


Lys Gly Glu Tyr Asp Val Thr Val Pro Lys Leu Glu Gly Glu Leu Lys 
465                 470                 475                 480 


Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro 
                485                 490                 495     


Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Val 
            500                 505                 510         


Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys 
        515                 520                 525             


Ala Asp Val Asp Ile Ser Gly Pro Lys Ile Asp Val Thr Ala Pro Asp 
    530                 535                 540                 


Val Ser Ile Glu Glu Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys 
545                 550                 555                 560 


Met Pro Glu Met Asn Ile Lys Val Pro Lys Ile Ser Met Pro Asp Val 
                565                 570                 575     


Asp Leu His Leu Lys Gly Pro Asn Val Lys Gly Glu Tyr Asp Val Thr 
            580                 585                 590         


Met Pro Lys Val Glu Ser Glu Ile Lys Val Pro Asp Val Glu Leu Lys 
        595                 600                 605             


Ser Ala Lys Met Asp Ile Asp Val Pro Asp Val Glu Val Gln Gly Pro 
    610                 615                 620                 


Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met 
625                 630                 635                 640 


Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys 
                645                 650                 655     


Ala Asp Val Asp Ile Ser Gly Pro Lys Val Gly Val Glu Val Pro Asp 
            660                 665                 670         


Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys 
        675                 680                 685             


Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Val 
    690                 695                 700                 


Asp Leu His Met Lys Gly Pro Lys Val Lys Gly Glu Tyr Asp Met Thr 
705                 710                 715                 720 


Val Pro Lys Leu Glu Gly Asp Leu Lys Gly Pro Lys Val Asp Val Ser 
                725                 730                 735     


Ala Pro Asp Val Glu Met Gln Gly Pro Asp Trp Asn Leu Lys Met Pro 
            740                 745                 750         


Lys Ile Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly 
        755                 760                 765             


Pro Glu Phe Asp Val Asn Leu Ser Lys Ala Asn Val Asp Ile Ser Ala 
    770                 775                 780                 


Pro Lys Val Asp Thr Asn Ala Pro Asp Leu Ser Leu Glu Gly Pro Glu 
785                 790                 795                 800 


Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Arg 
                805                 810                 815     


Ala Pro Lys Met Ser Leu Pro Asp Val Asp Leu Asp Leu Lys Gly Pro 
            820                 825                 830         


Lys Met Lys Gly Asn Val Asp Ile Ser Ala Pro Lys Ile Glu Gly Glu 
        835                 840                 845             


Met Gln Val Pro Asp Val Asp Ile Arg Gly Pro Lys Val Asp Ile Lys 
    850                 855                 860                 


Ala Pro Asp Val Glu Gly Gln Gly Leu Asp Trp Ser Leu Lys Ile Pro 
865                 870                 875                 880 


Lys Met Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly 
                885                 890                 895     


Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Val Ser Gly 
            900                 905                 910         


Pro Lys Val Asp Ile Glu Ala Pro Asp Val Ser Leu Glu Gly Pro Glu 
        915                 920                 925             


Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Lys 
    930                 935                 940                 


Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro 
945                 950                 955                 960 


Lys Val Lys Gly Asp Val Asp Val Ser Val Pro Lys Val Glu Gly Glu 
                965                 970                 975     


Met Lys Val Pro Asp Val Glu Ile Lys Gly Pro Lys Met Asp Ile Asp 
            980                 985                 990         


Ala Pro Asp Val Glu Val Gln Gly  Pro Asp Trp His Leu  Lys Met Pro 
        995                 1000                 1005             


Lys Met  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    1010                 1015                 1020             


Gly Arg  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    1025                 1030                 1035             


Ser Gly  Pro Lys Val Asp Val  Glu Val Pro Asp Val  Ser Leu Glu 
    1040                 1045                 1050             


Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    1055                 1060                 1065             


Met His  Phe Lys Ala Pro Lys  Ile Ser Met Pro Asp  Val Asp Leu 
    1070                 1075                 1080             


Asn Leu  Lys Gly Pro Lys Leu  Lys Gly Asp Val Asp  Val Ser Leu 
    1085                 1090                 1095             


Pro Glu  Val Glu Gly Glu Met  Lys Val Pro Asp Val  Asp Ile Lys 
    1100                 1105                 1110             


Gly Pro  Lys Val Asp Ile Ser  Ala Pro Asp Val Asp  Val His Gly 
    1115                 1120                 1125             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    1130                 1135                 1140             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Val Lys 
    1145                 1150                 1155             


Leu Pro  Lys Ala Asp Val Asp  Val Ser Gly Pro Lys  Met Asp Ala 
    1160                 1165                 1170             


Glu Val  Pro Asp Val Asn Ile  Glu Gly Pro Asp Ala  Lys Leu Lys 
    1175                 1180                 1185             


Gly Pro  Lys Phe Lys Met Pro  Glu Met Ser Ile Lys  Pro Gln Lys 
    1190                 1195                 1200             


Ile Ser  Ile Pro Asp Val Gly  Leu His Leu Lys Gly  Pro Lys Met 
    1205                 1210                 1215             


Lys Gly  Asp Tyr Asp Val Thr  Val Pro Lys Val Glu  Gly Glu Ile 
    1220                 1225                 1230             


Lys Ala  Pro Asp Val Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asn 
    1235                 1240                 1245             


Ala Pro  Asp Val Glu Val His  Gly Pro Asp Trp His  Leu Lys Met 
    1250                 1255                 1260             


Pro Lys  Val Lys Met Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly 
    1265                 1270                 1275             


Glu Gly  Pro Glu Val Asp Met  Asn Leu Pro Lys Ala  Asp Leu Gly 
    1280                 1285                 1290             


Val Ser  Gly Pro Lys Val Asp  Ile Asp Val Pro Asp  Val Asn Leu 
    1295                 1300                 1305             


Glu Ala  Pro Glu Gly Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro 
    1310                 1315                 1320             


Ser Met  Asn Ile Gln Thr His  Lys Ile Ser Met Pro  Asp Val Gly 
    1325                 1330                 1335             


Leu Asn  Leu Lys Ala Pro Lys  Leu Lys Thr Asp Val  Asp Val Ser 
    1340                 1345                 1350             


Leu Pro  Lys Val Glu Gly Asp  Leu Lys Gly Pro Glu  Ile Asp Val 
    1355                 1360                 1365             


Lys Ala  Pro Lys Met Asp Val  Asn Val Gly Asp Ile  Asp Ile Glu 
    1370                 1375                 1380             


Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    1385                 1390                 1395             


Met His  Phe Lys Ala Pro Lys  Ile Ser Met Pro Asp  Val Asp Leu 
    1400                 1405                 1410             


His Leu  Lys Gly Pro Lys Val  Lys Gly Asp Met Asp  Val Ser Val 
    1415                 1420                 1425             


Pro Lys  Val Glu Gly Glu Met  Lys Val Pro Asp Val  Asp Ile Lys 
    1430                 1435                 1440             


Gly Pro  Lys Val Asp Ile Asp  Ala Pro Asp Val Glu  Val His Asp 
    1445                 1450                 1455             


Pro Asp  Trp His Leu Lys Met  Pro Lys Met Lys Met  Pro Lys Phe 
    1460                 1465                 1470             


Ser Met  Pro Gly Phe Lys Ala  Glu Gly Pro Glu Val  Asp Val Asn 
    1475                 1480                 1485             


Leu Arg  Lys Ala Asp Ile Asp  Val Ser Gly Pro Ser  Val Asp Thr 
    1490                 1495                 1500             


Asp Ala  Pro Asp Leu Asp Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    1505                 1510                 1515             


Gly Ser  Lys Phe Lys Met Pro  Lys Leu Asn Ile Lys  Ala Pro Lys 
    1520                 1525                 1530             


Val Ser  Met Pro Asp Val Asp  Leu Asn Leu Lys Gly  Pro Lys Leu 
    1535                 1540                 1545             


Lys Gly  Glu Ile Asp Ala Ser  Val Pro Glu Leu Glu  Gly Asp Leu 
    1550                 1555                 1560             


Arg Gly  Pro Gln Val Asp Val  Lys Gly Pro Leu Val  Glu Ala Glu 
    1565                 1570                 1575             


Val Pro  Asp Val Asp Leu Glu  Cys Pro Asp Ala Lys  Leu Lys Gly 
    1580                 1585                 1590             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1595                 1600                 1605             


Ser Met  Pro Asp Val Asp Leu  His Leu Lys Gly Pro  Lys Val Lys 
    1610                 1615                 1620             


Gly Asp  Ala Asp Val Ser Val  Pro Lys Leu Glu Gly  Asp Leu Thr 
    1625                 1630                 1635             


Gly Pro  Ser Val Gly Val Glu  Val Pro Asp Val Glu  Leu Glu Cys 
    1640                 1645                 1650             


Pro Asp  Ala Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Asp Met 
    1655                 1660                 1665             


His Phe  Lys Ala Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1670                 1675                 1680             


Thr Leu  Pro Lys Val Glu Gly  Asp Leu Lys Gly Pro  Glu Ala Asp 
    1685                 1690                 1695             


Ile Lys  Gly Pro Lys Val Asp  Ile Asn Thr Pro Asp  Val Asp Val 
    1700                 1705                 1710             


His Gly  Pro Asp Trp His Leu  Lys Met Pro Lys Val  Lys Met Pro 
    1715                 1720                 1725             


Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu Gly Pro  Asp Val Asp 
    1730                 1735                 1740             


Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val Ser Gly  Pro Lys Val 
    1745                 1750                 1755             


Asp Val  Asp Val Pro Asp Val  Asn Ile Glu Gly Pro  Asp Ala Lys 
    1760                 1765                 1770             


Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu Met Ser  Ile Lys Ala 
    1775                 1780                 1785             


Pro Lys  Ile Ser Met Pro Asp  Ile Asp Leu Asn Leu  Lys Gly Pro 
    1790                 1795                 1800             


Lys Val  Lys Gly Asp Val Asp  Val Thr Leu Pro Lys  Val Glu Gly 
    1805                 1810                 1815             


Asp Leu  Lys Gly Pro Glu Ala  Asp Ile Lys Gly Pro  Lys Val Asp 
    1820                 1825                 1830             


Ile Asn  Thr Pro Asp Val Asp  Val His Gly Pro Asp  Trp His Leu 
    1835                 1840                 1845             


Lys Met  Pro Lys Val Lys Met  Pro Lys Phe Ser Met  Pro Gly Phe 
    1850                 1855                 1860             


Lys Gly  Glu Gly Pro Asp Val  Asp Val Ser Leu Pro  Lys Ala Asp 
    1865                 1870                 1875             


Ile Asp  Val Ser Gly Pro Lys  Val Asp Val Asp Ile  Pro Asp Val 
    1880                 1885                 1890             


Asn Ile  Glu Gly Pro Asp Pro  Lys Leu Lys Val Pro  Lys Val Lys 
    1895                 1900                 1905             


Met Pro  Glu Ile Asn Ile Lys  Ala Pro Lys Ile Ser  Ile Pro Asp 
    1910                 1915                 1920             


Val Asp  Leu Asp Leu Lys Gly  Pro Lys Val Lys Gly  Asp Phe Asp 
    1925                 1930                 1935             


Val Ser  Val Pro Lys Val Glu  Gly Thr Leu Lys Gly  Pro Glu Val 
    1940                 1945                 1950             


Asp Leu  Lys Gly Pro Arg Leu  Asp Phe Glu Gly Pro  Asp Ala Lys 
    1955                 1960                 1965             


Leu Ser  Gly Pro Ser Leu Lys  Met Pro Ser Leu Glu  Ile Ser Ala 
    1970                 1975                 1980             


Pro Lys  Val Thr Ala Pro Asp  Val Asp Leu His Leu  Lys Ala Pro 
    1985                 1990                 1995             


Lys Ile  Gly Phe Ser Gly Pro  Lys Leu Glu Gly Gly  Glu Val Asp 
    2000                 2005                 2010             


Leu Lys  Gly Pro Lys Val Glu  Ala Pro Ser Leu Asp  Val His Met 
    2015                 2020                 2025             


Asp Ser  Pro Asp Ile Asn Ile  Glu Gly Pro Asp Val  Lys Ile Pro 
    2030                 2035                 2040             


Lys Phe  Lys Lys Pro Lys Phe  Gly Phe Gly Pro Lys  Ser Pro Lys 
    2045                 2050                 2055             


Ala Asp  Ile Lys Ser Pro Ser  Leu Asp Val Thr Val  Pro Glu Ala 
    2060                 2065                 2070             


Glu Leu  Asn Leu Glu Thr Pro  Glu Ile Ser Val Gly  Gly Lys Gly 
    2075                 2080                 2085             


Lys Lys  Ser Lys Phe Lys Met  Pro Lys Ile His Met  Ser Gly Pro 
    2090                 2095                 2100             


Lys Ile  Lys Ala Lys Lys Gln  Gly Phe Asp Leu Asn  Val Pro Gly 
    2105                 2110                 2115             


Gly Glu  Ile Asp Ala Ser Leu  Lys Ala Pro Asp Val  Asp Val Asn 
    2120                 2125                 2130             


Ile Ala  Gly Pro Asp Ala Ala  Leu Lys Val Asp Val  Lys Ser Pro 
    2135                 2140                 2145             


Lys Thr  Lys Lys Thr Met Phe  Gly Lys Met Tyr Phe  Pro Asp Val 
    2150                 2155                 2160             


Glu Phe  Asp Ile Lys Ser Pro  Lys Phe Lys Ala Glu  Ala Pro Leu 
    2165                 2170                 2175             


Pro Ser  Pro Lys Leu Glu Gly  Glu Leu Gln Ala Pro  Asp Leu Glu 
    2180                 2185                 2190             


Leu Ser  Leu Pro Ala Ile His  Val Glu Gly Leu Asp  Ile Lys Ala 
    2195                 2200                 2205             


Lys Ala  Pro Lys Val Lys Met  Pro Asp Val Asp Ile  Ser Val Pro 
    2210                 2215                 2220             


Lys Ile  Glu Gly Asp Leu Lys  Gly Pro Lys Val Gln  Ala Asn Leu 
    2225                 2230                 2235             


Gly Ala  Pro Asp Ile Asn Ile  Glu Gly Leu Asp Ala  Lys Val Lys 
    2240                 2245                 2250             


Thr Pro  Ser Phe Gly Ile Ser  Ala Pro Gln Val Ser  Ile Pro Asp 
    2255                 2260                 2265             


Val Asn  Val Asn Leu Lys Gly  Pro Lys Ile Lys Gly  Asp Val Pro 
    2270                 2275                 2280             


Ser Val  Gly Leu Glu Gly Pro  Asp Val Asp Leu Gln  Gly Pro Glu 
    2285                 2290                 2295             


Ala Lys  Ile Lys Phe Pro Lys  Phe Ser Met Pro Lys  Ile Gly Ile 
    2300                 2305                 2310             


Pro Gly  Val Lys Met Glu Gly  Gly Gly Ala Glu Val  His Ala Gln 
    2315                 2320                 2325             


Leu Pro  Ser Leu Glu Gly Asp  Leu Arg Gly Pro Asp  Val Lys Leu 
    2330                 2335                 2340             


Glu Gly  Pro Asp Val Ser Leu  Lys Gly Pro Gly Val  Asp Leu Pro 
    2345                 2350                 2355             


Ser Val  Asn Leu Ser Met Pro  Lys Val Ser Gly Pro  Asp Leu Asp 
    2360                 2365                 2370             


Leu Asn  Leu Lys Gly Pro Ser  Leu Lys Gly Asp Leu  Asp Ala Ser 
    2375                 2380                 2385             


Val Pro  Ser Met Lys Val His  Ala Pro Gly Leu Asn  Leu Ser Gly 
    2390                 2395                 2400             


Val Gly  Gly Lys Met Gln Val  Gly Gly Asp Gly Val  Lys Val Pro 
    2405                 2410                 2415             


Gly Ile  Asp Ala Thr Thr Lys  Leu Asn Val Gly Ala  Pro Asp Val 
    2420                 2425                 2430             


Thr Leu  Arg Gly Pro Ser Leu  Gln Gly Asp Leu Ala  Val Ser Gly 
    2435                 2440                 2445             


Asp Ile  Lys Cys Pro Lys Val  Ser Val Gly Ala Pro  Asp Leu Ser 
    2450                 2455                 2460             


Leu Glu  Ala Ser Glu Gly Ser  Ile Lys Leu Pro Lys  Met Lys Leu 
    2465                 2470                 2475             


Pro Gln  Phe Gly Ile Ser Thr  Pro Gly Ser Asp Leu  His Val Asn 
    2480                 2485                 2490             


Ala Lys  Gly Pro Gln Val Ser  Gly Glu Leu Lys Gly  Pro Gly Val 
    2495                 2500                 2505             


Asp Val  Asn Leu Lys Gly Ser  Arg Ile Ser Ala Pro  Asn Val Asp 
    2510                 2515                 2520             


Phe Asn  Leu Glu Gly Pro Lys  Val Lys Gly Ser Leu  Gly Ala Thr 
    2525                 2530                 2535             


Gly Glu  Ile Lys Gly Pro Thr  Val Gly Gly Gly Leu  Pro Gly Ile 
    2540                 2545                 2550             


Gly Val  Gln Gly Leu Glu Gly  Asn Leu Gln Met Pro  Gly Ile Lys 
    2555                 2560                 2565             


Ser Ser  Gly Cys Asp Val Asn  Leu Pro Gly Val Asn  Val Lys Leu 
    2570                 2575                 2580             


Pro Thr  Gly Gln Ile Ser Gly  Pro Glu Ile Lys Gly  Gly Leu Lys 
    2585                 2590                 2595             


Gly Ser  Glu Val Gly Phe His  Gly Ala Ala Pro Asp  Ile Ser Val 
    2600                 2605                 2610             


Lys Gly  Pro Ala Phe Asn Met  Ala Ser Pro Glu Ser  Asp Phe Gly 
    2615                 2620                 2625             


Ile Asn  Leu Lys Gly Pro Lys  Ile Lys Gly Gly Ala  Asp Val Ser 
    2630                 2635                 2640             


Gly Gly  Val Ser Ala Pro Asp  Ile Ser Leu Gly Glu  Gly His Leu 
    2645                 2650                 2655             


Ser Val  Lys Gly Ser Gly Gly  Glu Trp Lys Gly Pro  Gln Val Ser 
    2660                 2665                 2670             


Ser Ala  Leu Asn Leu Asp Thr  Ser Lys Phe Ala Gly  Gly Leu His 
    2675                 2680                 2685             


Phe Ser  Gly Pro Lys Val Glu  Gly Gly Val Lys Gly  Gly Gln Ile 
    2690                 2695                 2700             


Gly Leu  Gln Ala Pro Gly Leu  Ser Val Ser Gly Pro  Gln Gly His 
    2705                 2710                 2715             


Leu Glu  Ser Gly Ser Gly Lys  Val Thr Phe Pro Lys  Met Lys Ile 
    2720                 2725                 2730             


Pro Lys  Phe Thr Phe Ser Gly  Arg Glu Leu Val Gly  Arg Glu Met 
    2735                 2740                 2745             


Gly Val  Asp Val His Phe Pro  Lys Ala Glu Ala Ser  Ile Gln Ala 
    2750                 2755                 2760             


Gly Ala  Gly Asp Gly Glu Trp  Glu Glu Ser Glu Val  Lys Leu Lys 
    2765                 2770                 2775             


Lys Ser  Lys Ile Lys Met Pro  Lys Phe Asn Phe Ser  Lys Pro Lys 
    2780                 2785                 2790             


Gly Lys  Gly Gly Val Thr Gly  Ser Pro Glu Ala Ser  Ile Ser Gly 
    2795                 2800                 2805             


Ser Lys  Gly Asp Leu Lys Ser  Ser Lys Ala Ser Leu  Gly Ser Leu 
    2810                 2815                 2820             


Glu Gly  Glu Ala Glu Ala Glu  Ala Ser Ser Pro Lys  Gly Lys Phe 
    2825                 2830                 2835             


Ser Leu  Phe Lys Ser Lys Lys  Pro Arg His Arg Ser  Asn Ser Phe 
    2840                 2845                 2850             


Ser Asp  Glu Arg Glu Phe Ser  Gly Pro Ser Thr Pro  Thr Gly Thr 
    2855                 2860                 2865             


Leu Glu  Phe Glu Gly Gly Glu  Val Ser Leu Glu Gly  Gly Lys Val 
    2870                 2875                 2880             


Lys Gly  Lys His Gly Lys Leu  Lys Phe Gly Thr Phe  Gly Gly Leu 
    2885                 2890                 2895             


Gly Ser  Lys Ser Lys Gly His  Tyr Glu Val Thr Gly  Ser Asp Asp 
    2900                 2905                 2910             


Glu Thr  Gly Lys Leu Gln Gly  Ser Gly Val Ser Leu  Ala Ser Lys 
    2915                 2920                 2925             


Lys Ser  Arg Leu Ser Ser Ser  Ser Ser Asn Asp Ser  Gly Asn Lys 
    2930                 2935                 2940             


Val Gly  Ile Gln Leu Pro Glu  Val Glu Leu Ser Val  Ser Thr Lys 
    2945                 2950                 2955             


Lys Glu  
    2960 


<210>  190
<211>  390
<212>  PRT
<213>  homo sapiens

<400>  190

Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly Ser Arg 
1               5                   10                  15      


Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile Pro Phe 
            20                  25                  30          


Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro Ala Pro 
        35                  40                  45              


Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu 
    50                  55                  60                  


Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val Thr Lys 
65                  70                  75                  80  


Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr Phe Glu 
                85                  90                  95      


Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr 
            100                 105                 110         


Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu Lys Ile 
        115                 120                 125             


Leu Pro Thr Leu Glu Ala Val Ala Ala Leu Gly Asn Lys Val Val Glu 
    130                 135                 140                 


Ser Leu Arg Ala Gln Asp Pro Ser Glu Val Leu Thr Met Leu Thr Asn 
145                 150                 155                 160 


Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys Ile Leu 
                165                 170                 175     


Ile Thr Thr Val Pro Pro Asn Leu Arg Lys Leu Asp Pro Glu Leu His 
            180                 185                 190         


Leu Asp Ile Lys Val Leu Gln Ser Ala Leu Ala Ala Ile Arg His Ala 
        195                 200                 205             


Arg Trp Phe Glu Glu Asn Ala Ser Gln Ser Thr Val Lys Val Leu Ile 
    210                 215                 220                 


Arg Leu Leu Lys Asp Leu Arg Ile Arg Phe Pro Gly Phe Glu Pro Leu 
225                 230                 235                 240 


Thr Pro Trp Ile Leu Asp Leu Leu Gly His Tyr Ala Val Met Asn Asn 
                245                 250                 255     


Pro Thr Arg Gln Pro Leu Ala Leu Asn Val Ala Tyr Arg Arg Cys Leu 
            260                 265                 270         


Gln Ile Leu Ala Ala Gly Leu Phe Leu Pro Gly Ser Val Gly Ile Thr 
        275                 280                 285             


Asp Pro Cys Glu Ser Gly Asn Phe Arg Val His Thr Val Met Thr Leu 
    290                 295                 300                 


Glu Gln Gln Asp Met Val Cys Tyr Thr Ala Gln Thr Leu Val Arg Ile 
305                 310                 315                 320 


Leu Ser His Gly Gly Phe Arg Lys Ile Leu Gly Gln Glu Gly Asp Ala 
                325                 330                 335     


Ser Tyr Leu Ala Ser Glu Ile Ser Thr Trp Asp Gly Val Ile Val Thr 
            340                 345                 350         


Pro Ser Glu Lys Ala Tyr Glu Lys Pro Pro Glu Lys Lys Glu Gly Glu 
        355                 360                 365             


Glu Glu Glu Glu Asn Thr Glu Glu Pro Pro Gln Gly Glu Glu Glu Glu 
    370                 375                 380                 


Ser Met Glu Thr Gln Glu 
385                 390 


<210>  191
<211>  594
<212>  PRT
<213>  homo sapiens

<400>  191

Met Val Leu Leu His Val Leu Phe Glu His Ala Val Gly Tyr Ala Leu 
1               5                   10                  15      


Leu Ala Leu Lys Glu Val Glu Glu Ile Ser Leu Leu Gln Pro Gln Val 
            20                  25                  30          


Glu Glu Ser Val Leu Asn Leu Gly Lys Phe His Ser Ile Val Arg Leu 
        35                  40                  45              


Val Ala Phe Cys Pro Phe Ala Ser Ser Gln Val Ala Leu Glu Asn Ala 
    50                  55                  60                  


Asn Ala Val Ser Glu Gly Val Val His Glu Asp Leu Arg Leu Leu Leu 
65                  70                  75                  80  


Glu Thr His Leu Pro Ser Lys Lys Lys Lys Val Leu Leu Gly Val Gly 
                85                  90                  95      


Asp Pro Lys Ile Gly Ala Ala Ile Gln Glu Glu Leu Gly Tyr Asn Cys 
            100                 105                 110         


Gln Thr Gly Gly Val Ile Ala Glu Ile Leu Arg Gly Val Arg Leu His 
        115                 120                 125             


Phe His Asn Leu Val Lys Gly Leu Thr Asp Leu Ser Ala Cys Lys Ala 
    130                 135                 140                 


Gln Leu Gly Leu Gly His Ser Tyr Ser Arg Ala Lys Val Lys Phe Asn 
145                 150                 155                 160 


Val Asn Arg Val Asp Asn Met Ile Ile Gln Ser Ile Ser Leu Leu Asp 
                165                 170                 175     


Gln Leu Asp Lys Asp Ile Asn Thr Phe Ser Met Arg Val Arg Glu Trp 
            180                 185                 190         


Tyr Gly Tyr His Phe Pro Glu Leu Val Lys Ile Ile Asn Asp Asn Ala 
        195                 200                 205             


Thr Tyr Cys Arg Leu Ala Gln Phe Ile Gly Asn Arg Arg Glu Leu Asn 
    210                 215                 220                 


Glu Asp Lys Leu Glu Lys Leu Glu Glu Leu Thr Met Asp Gly Ala Lys 
225                 230                 235                 240 


Ala Lys Ala Ile Leu Asp Ala Ser Arg Ser Ser Met Gly Met Asp Ile 
                245                 250                 255     


Ser Ala Ile Asp Leu Ile Asn Ile Glu Ser Phe Ser Ser Arg Val Val 
            260                 265                 270         


Ser Leu Ser Glu Tyr Arg Gln Ser Leu His Thr Tyr Leu Arg Ser Lys 
        275                 280                 285             


Met Ser Gln Val Ala Pro Ser Leu Ser Ala Leu Ile Gly Glu Ala Val 
    290                 295                 300                 


Gly Ala Arg Leu Ile Ala His Ala Gly Ser Leu Thr Asn Leu Ala Lys 
305                 310                 315                 320 


Tyr Pro Ala Ser Thr Val Gln Ile Leu Gly Ala Glu Lys Ala Leu Phe 
                325                 330                 335     


Arg Ala Leu Lys Thr Arg Gly Asn Thr Pro Lys Tyr Gly Leu Ile Phe 
            340                 345                 350         


His Ser Thr Phe Ile Gly Arg Ala Ala Ala Lys Asn Lys Gly Arg Ile 
        355                 360                 365             


Ser Arg Tyr Leu Ala Asn Lys Cys Ser Ile Ala Ser Arg Ile Asp Cys 
    370                 375                 380                 


Phe Ser Glu Val Pro Thr Ser Val Phe Gly Glu Lys Leu Arg Glu Gln 
385                 390                 395                 400 


Val Glu Glu Arg Leu Ser Phe Tyr Glu Thr Gly Glu Ile Pro Arg Lys 
                405                 410                 415     


Asn Leu Asp Val Met Lys Glu Ala Met Val Gln Ala Glu Glu Ala Ala 
            420                 425                 430         


Ala Glu Ile Thr Arg Lys Leu Glu Lys Gln Glu Lys Lys Arg Leu Lys 
        435                 440                 445             


Lys Glu Lys Lys Arg Leu Ala Ala Leu Ala Leu Ala Ser Ser Glu Asn 
    450                 455                 460                 


Ser Ser Ser Thr Pro Glu Glu Cys Glu Glu Met Ser Glu Lys Pro Lys 
465                 470                 475                 480 


Lys Lys Lys Lys Gln Lys Pro Gln Glu Val Pro Gln Glu Asn Gly Met 
                485                 490                 495     


Glu Asp Pro Ser Ile Ser Phe Ser Lys Pro Lys Lys Lys Lys Ser Phe 
            500                 505                 510         


Ser Lys Glu Glu Leu Met Ser Ser Asp Leu Glu Glu Thr Ala Gly Ser 
        515                 520                 525             


Thr Ser Ile Pro Lys Arg Lys Lys Ser Thr Pro Lys Glu Glu Thr Val 
    530                 535                 540                 


Asn Asp Pro Glu Glu Ala Gly His Arg Ser Gly Ser Lys Lys Lys Arg 
545                 550                 555                 560 


Lys Phe Ser Lys Glu Glu Pro Val Ser Ser Gly Pro Glu Glu Ala Val 
                565                 570                 575     


Gly Lys Ser Ser Ser Lys Lys Lys Lys Lys Phe His Lys Ala Ser Gln 
            580                 585                 590         


Glu Asp 
        


<210>  192
<211>  336
<212>  PRT
<213>  homo sapiens

<400>  192

Met Glu Lys Leu Arg Leu Leu Gly Leu Arg Tyr Gln Glu Tyr Val Thr 
1               5                   10                  15      


Arg His Pro Ala Ala Thr Ala Gln Leu Glu Thr Ala Val Arg Gly Phe 
            20                  25                  30          


Ser Tyr Leu Leu Ala Gly Arg Phe Ala Asp Ser His Glu Leu Ser Glu 
        35                  40                  45              


Leu Val Tyr Ser Ala Ser Asn Leu Leu Val Leu Leu Asn Asp Gly Ile 
    50                  55                  60                  


Leu Arg Lys Glu Leu Arg Lys Lys Leu Pro Val Ser Leu Ser Gln Gln 
65                  70                  75                  80  


Lys Leu Leu Thr Trp Leu Ser Val Leu Glu Cys Val Glu Val Phe Met 
                85                  90                  95      


Glu Met Gly Ala Ala Lys Val Trp Gly Glu Val Gly Arg Trp Leu Val 
            100                 105                 110         


Ile Ala Leu Ile Gln Leu Ala Lys Ala Val Leu Arg Met Leu Leu Leu 
        115                 120                 125             


Leu Trp Phe Lys Ala Gly Leu Gln Thr Ser Pro Pro Ile Val Pro Leu 
    130                 135                 140                 


Asp Arg Glu Thr Gln Ala Gln Pro Pro Asp Gly Asp His Ser Pro Gly 
145                 150                 155                 160 


Asn His Glu Gln Ser Tyr Val Gly Lys Arg Ser Asn Arg Val Val Arg 
                165                 170                 175     


Thr Leu Gln Asn Thr Pro Ser Leu His Ser Arg His Trp Gly Ala Pro 
            180                 185                 190         


Gln Gln Arg Glu Gly Arg Gln Gln Gln His His Glu Glu Leu Ser Ala 
        195                 200                 205             


Thr Pro Thr Pro Leu Gly Leu Gln Glu Thr Ile Ala Glu Phe Leu Tyr 
    210                 215                 220                 


Ile Ala Arg Pro Leu Leu His Leu Leu Ser Leu Gly Leu Trp Gly Gln 
225                 230                 235                 240 


Arg Ser Trp Lys Pro Trp Leu Leu Ala Gly Val Val Asp Val Thr Ser 
                245                 250                 255     


Leu Ser Leu Leu Ser Asp Arg Lys Gly Leu Thr Arg Arg Glu Arg Arg 
            260                 265                 270         


Glu Leu Arg Arg Arg Thr Ile Leu Leu Leu Tyr Tyr Leu Leu Arg Ser 
        275                 280                 285             


Pro Phe Tyr Asp Arg Phe Ser Glu Ala Arg Ile Leu Phe Leu Leu Gln 
    290                 295                 300                 


Leu Leu Ala Asp His Val Pro Gly Val Gly Leu Val Thr Arg Pro Leu 
305                 310                 315                 320 


Met Asp Tyr Leu Pro Thr Trp Gln Lys Ile Tyr Phe Tyr Ser Trp Gly 
                325                 330                 335     


<210>  193
<211>  376
<212>  PRT
<213>  homo sapiens

<400>  193

Met Asp Val Leu Ala Glu Ala Asn Gly Thr Phe Ala Leu Asn Leu Leu 
1               5                   10                  15      


Lys Thr Leu Gly Lys Asp Asn Ser Lys Asn Val Phe Phe Ser Pro Met 
            20                  25                  30          


Ser Met Ser Cys Ala Leu Ala Met Val Tyr Met Gly Ala Lys Gly Asn 
        35                  40                  45              


Thr Ala Ala Gln Met Ala Gln Ile Leu Ser Phe Asn Lys Ser Gly Gly 
    50                  55                  60                  


Gly Gly Asp Ile His Gln Gly Phe Gln Ser Leu Leu Thr Glu Val Asn 
65                  70                  75                  80  


Lys Thr Gly Thr Gln Tyr Leu Leu Arg Val Ala Asn Arg Leu Phe Gly 
                85                  90                  95      


Glu Lys Ser Cys Asp Phe Leu Ser Ser Phe Arg Asp Ser Cys Gln Lys 
            100                 105                 110         


Phe Tyr Gln Ala Glu Met Glu Glu Leu Asp Phe Ile Ser Ala Val Glu 
        115                 120                 125             


Lys Ser Arg Lys His Ile Asn Thr Trp Val Ala Glu Lys Thr Glu Gly 
    130                 135                 140                 


Lys Ile Ala Glu Leu Leu Ser Pro Gly Ser Val Asp Pro Leu Thr Arg 
145                 150                 155                 160 


Leu Val Leu Val Asn Ala Val Tyr Phe Arg Gly Asn Trp Asp Glu Gln 
                165                 170                 175     


Phe Asp Lys Glu Asn Thr Glu Glu Arg Leu Phe Lys Val Ser Lys Asn 
            180                 185                 190         


Glu Glu Lys Pro Val Gln Met Met Phe Lys Gln Ser Thr Phe Lys Lys 
        195                 200                 205             


Thr Tyr Ile Gly Glu Ile Phe Thr Gln Ile Leu Val Leu Pro Tyr Val 
    210                 215                 220                 


Gly Lys Glu Leu Asn Met Ile Ile Met Leu Pro Asp Glu Thr Thr Asp 
225                 230                 235                 240 


Leu Arg Thr Val Glu Lys Glu Leu Thr Tyr Glu Lys Phe Val Glu Trp 
                245                 250                 255     


Thr Arg Leu Asp Met Met Asp Glu Glu Glu Val Glu Val Ser Leu Pro 
            260                 265                 270         


Arg Phe Lys Leu Glu Glu Ser Tyr Asp Met Glu Ser Val Leu Arg Asn 
        275                 280                 285             


Leu Gly Met Thr Asp Ala Phe Glu Leu Gly Lys Ala Asp Phe Ser Gly 
    290                 295                 300                 


Met Ser Gln Thr Asp Leu Ser Leu Ser Lys Val Val His Lys Ser Phe 
305                 310                 315                 320 


Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Ala 
                325                 330                 335     


Ile Met Met Met Arg Cys Ala Arg Phe Val Pro Arg Phe Cys Ala Asp 
            340                 345                 350         


His Pro Phe Leu Phe Phe Ile Gln His Ser Lys Thr Asn Gly Ile Leu 
        355                 360                 365             


Phe Cys Gly Arg Phe Ser Ser Pro 
    370                 375     


<210>  194
<211>  472
<212>  PRT
<213>  homo sapiens

<400>  194

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  195
<211>  4684
<212>  PRT
<213>  homo sapiens

<400>  195

Met Val Ala Gly Met Leu Met Pro Arg Asp Gln Leu Arg Ala Ile Tyr 
1               5                   10                  15      


Glu Val Leu Phe Arg Glu Gly Val Met Val Ala Lys Lys Asp Arg Arg 
            20                  25                  30          


Pro Arg Ser Leu His Pro His Val Pro Gly Val Thr Asn Leu Gln Val 
        35                  40                  45              


Met Arg Ala Met Ala Ser Leu Arg Ala Arg Gly Leu Val Arg Glu Thr 
    50                  55                  60                  


Phe Ala Trp Cys His Phe Phe Trp Tyr Leu Thr Asn Glu Gly Ile Ala 
65                  70                  75                  80  


His Leu Arg Gln Tyr Leu His Leu Pro Pro Glu Ile Val Ala Ala Ser 
                85                  90                  95      


Leu Gln Arg Val Arg Arg Pro Val Ala Met Val Met Pro Ala Arg Arg 
            100                 105                 110         


Thr Pro His Val Gln Ala Val Gln Gly Pro Leu Gly Ser Pro Pro Lys 
        115                 120                 125             


Arg Gly Pro Leu Pro Thr Glu Glu Gln Arg Leu Tyr Arg Arg Lys Glu 
    130                 135                 140                 


Leu Glu Glu Val Ser Pro Glu Thr Pro Val Val Pro Ala Thr Thr Gln 
145                 150                 155                 160 


Arg Thr Leu Ala Arg Pro Gly Pro Glu Pro Ala Pro Ala Thr Asp Glu 
                165                 170                 175     


Arg Asp Arg Val Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His 
            180                 185                 190         


Leu Ile Lys Ala Gln Arg His Ile Ser Asp Leu Tyr Glu Asp Leu Arg 
        195                 200                 205             


Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Ser 
    210                 215                 220                 


Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Lys Leu Gln Asn Val 
225                 230                 235                 240 


Gln Ile Ala Leu Asp Tyr Leu Arg His Arg Gln Val Lys Leu Val Asn 
                245                 250                 255     


Ile Arg Asn Asp Asp Ile Ala Asp Gly Asn Pro Lys Leu Thr Leu Gly 
            260                 265                 270         


Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile Gln Val 
        275                 280                 285             


Ser Gly Gln Ser Glu Asp Met Thr Ala Lys Glu Lys Leu Leu Leu Trp 
    290                 295                 300                 


Ser Gln Arg Met Val Glu Gly Tyr Gln Gly Leu Arg Cys Asp Asn Phe 
305                 310                 315                 320 


Thr Ser Ser Trp Arg Asp Gly Arg Leu Phe Asn Ala Ile Ile His Arg 
                325                 330                 335     


His Lys Pro Leu Leu Ile Asp Met Asn Lys Val Tyr Arg Gln Thr Asn 
            340                 345                 350         


Leu Glu Asn Leu Asp Gln Ala Phe Ser Val Ala Glu Arg Asp Leu Gly 
        355                 360                 365             


Val Thr Arg Leu Leu Asp Pro Glu Asp Val Asp Val Pro Gln Pro Asp 
    370                 375                 380                 


Glu Lys Ser Ile Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Met Pro 
385                 390                 395                 400 


Arg Val Pro Asp Val Gln Asp Gly Val Arg Ala Asn Glu Leu Gln Leu 
                405                 410                 415     


Arg Trp Gln Glu Tyr Arg Glu Leu Val Leu Leu Leu Leu Gln Trp Met 
            420                 425                 430         


Arg His His Thr Ala Ala Phe Glu Glu Arg Arg Phe Pro Ser Ser Phe 
        435                 440                 445             


Glu Glu Ile Glu Ile Leu Trp Ser Gln Phe Leu Lys Phe Lys Glu Met 
    450                 455                 460                 


Glu Leu Pro Ala Lys Glu Ala Asp Lys Asn Arg Ser Lys Gly Ile Tyr 
465                 470                 475                 480 


Gln Ser Leu Glu Gly Ala Val Gln Ala Gly Gln Leu Lys Val Pro Pro 
                485                 490                 495     


Gly Tyr His Pro Leu Asp Val Glu Lys Glu Trp Gly Lys Leu His Val 
            500                 505                 510         


Ala Ile Leu Glu Arg Glu Lys Gln Leu Arg Ser Glu Phe Glu Arg Leu 
        515                 520                 525             


Glu Cys Leu Gln Arg Ile Val Thr Lys Leu Gln Met Glu Ala Gly Leu 
    530                 535                 540                 


Cys Glu Glu Gln Leu Asn Gln Ala Asp Ala Leu Leu Gln Ser Asp Val 
545                 550                 555                 560 


Arg Leu Leu Ala Ala Gly Lys Val Pro Gln Arg Ala Gly Glu Val Glu 
                565                 570                 575     


Arg Asp Leu Asp Lys Ala Asp Ser Met Ile Arg Leu Leu Phe Asn Asp 
            580                 585                 590         


Val Gln Thr Leu Lys Asp Gly Arg His Pro Gln Gly Glu Gln Met Tyr 
        595                 600                 605             


Arg Arg Val Tyr Arg Leu His Glu Arg Leu Val Ala Ile Arg Thr Glu 
    610                 615                 620                 


Tyr Asn Leu Arg Leu Lys Ala Gly Val Ala Ala Pro Ala Thr Gln Val 
625                 630                 635                 640 


Ala Gln Val Thr Leu Gln Ser Val Gln Arg Arg Pro Glu Leu Glu Asp 
                645                 650                 655     


Ser Thr Leu Arg Tyr Leu Gln Asp Leu Leu Ala Trp Val Glu Glu Asn 
            660                 665                 670         


Gln His Arg Val Asp Gly Ala Glu Trp Gly Val Asp Leu Pro Ser Val 
        675                 680                 685             


Glu Ala Gln Leu Gly Ser His Arg Gly Leu His Gln Ser Ile Glu Glu 
    690                 695                 700                 


Phe Arg Ala Lys Ile Glu Arg Ala Arg Ser Asp Glu Gly Gln Leu Ser 
705                 710                 715                 720 


Pro Ala Thr Arg Gly Ala Tyr Arg Asp Cys Leu Gly Arg Leu Asp Leu 
                725                 730                 735     


Gln Tyr Ala Lys Leu Leu Asn Ser Ser Lys Ala Arg Leu Arg Ser Leu 
            740                 745                 750         


Glu Ser Leu His Ser Phe Val Ala Ala Ala Thr Lys Glu Leu Met Trp 
        755                 760                 765             


Leu Asn Glu Lys Glu Glu Glu Glu Val Gly Phe Asp Trp Ser Asp Arg 
    770                 775                 780                 


Asn Thr Asn Met Thr Ala Lys Lys Glu Ser Tyr Ser Ala Leu Met Arg 
785                 790                 795                 800 


Glu Leu Glu Leu Lys Glu Lys Lys Ile Lys Glu Leu Gln Asn Ala Gly 
                805                 810                 815     


Asp Arg Leu Leu Arg Glu Asp His Pro Ala Arg Pro Thr Val Glu Ser 
            820                 825                 830         


Phe Gln Ala Ala Leu Gln Thr Gln Trp Ser Trp Met Leu Gln Leu Cys 
        835                 840                 845             


Cys Cys Ile Glu Ala His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe 
    850                 855                 860                 


Phe Ser Asp Val Arg Glu Ala Glu Gly Gln Leu Gln Lys Leu Gln Glu 
865                 870                 875                 880 


Ala Leu Arg Arg Lys Tyr Ser Cys Asp Arg Ser Ala Thr Val Thr Arg 
                885                 890                 895     


Leu Glu Asp Leu Leu Gln Asp Ala Gln Asp Glu Lys Glu Gln Leu Asn 
            900                 905                 910         


Glu Tyr Lys Gly His Leu Ser Gly Leu Ala Lys Arg Ala Lys Ala Val 
        915                 920                 925             


Val Gln Leu Lys Pro Arg His Pro Ala His Pro Met Arg Gly Arg Leu 
    930                 935                 940                 


Pro Leu Leu Ala Val Cys Asp Tyr Lys Gln Val Glu Val Thr Val His 
945                 950                 955                 960 


Lys Gly Asp Glu Cys Gln Leu Val Gly Pro Ala Gln Pro Ser His Trp 
                965                 970                 975     


Lys Val Leu Ser Ser Ser Gly Ser Glu Ala Ala Val Pro Ser Val Cys 
            980                 985                 990         


Phe Leu Val Pro Pro Pro Asn Gln  Glu Ala Gln Glu Ala  Val Thr Arg 
        995                 1000                 1005             


Leu Glu  Ala Gln His Gln Ala  Leu Val Thr Leu Trp  His Gln Leu 
    1010                 1015                 1020             


His Val  Asp Met Lys Ser Leu  Leu Ala Trp Gln Ser  Leu Arg Arg 
    1025                 1030                 1035             


Asp Val  Gln Leu Ile Arg Ser  Trp Ser Leu Ala Thr  Phe Arg Thr 
    1040                 1045                 1050             


Leu Lys  Pro Glu Glu Gln Arg  Gln Ala Leu His Ser  Leu Glu Leu 
    1055                 1060                 1065             


His Tyr  Gln Ala Phe Leu Arg  Asp Ser Gln Asp Ala  Gly Gly Phe 
    1070                 1075                 1080             


Gly Pro  Glu Asp Arg Leu Met  Ala Glu Arg Glu Tyr  Gly Ser Cys 
    1085                 1090                 1095             


Ser His  His Tyr Gln Gln Leu  Leu Gln Ser Leu Glu  Gln Gly Ala 
    1100                 1105                 1110             


Gln Glu  Glu Ser Arg Cys Gln  Arg Cys Ile Ser Glu  Leu Lys Asp 
    1115                 1120                 1125             


Ile Arg  Leu Gln Leu Glu Ala  Cys Glu Thr Arg Thr  Val His Arg 
    1130                 1135                 1140             


Leu Arg  Leu Pro Leu Asp Lys  Glu Pro Ala Arg Glu  Cys Ala Gln 
    1145                 1150                 1155             


Arg Ile  Ala Glu Gln Gln Lys  Ala Gln Ala Glu Val  Glu Gly Leu 
    1160                 1165                 1170             


Gly Lys  Gly Val Ala Arg Leu  Ser Ala Glu Ala Glu  Lys Val Leu 
    1175                 1180                 1185             


Ala Leu  Pro Glu Pro Ser Pro  Ala Ala Pro Thr Leu  Arg Ser Glu 
    1190                 1195                 1200             


Leu Glu  Leu Thr Leu Gly Lys  Leu Glu Gln Val Arg  Ser Leu Ser 
    1205                 1210                 1215             


Ala Ile  Tyr Leu Glu Lys Leu  Lys Thr Ile Ser Leu  Val Ile Arg 
    1220                 1225                 1230             


Gly Thr  Gln Gly Ala Glu Glu  Val Leu Arg Ala His  Glu Glu Gln 
    1235                 1240                 1245             


Leu Lys  Glu Ala Gln Ala Val  Pro Ala Thr Leu Pro  Glu Leu Glu 
    1250                 1255                 1260             


Ala Thr  Lys Ala Ser Leu Lys  Lys Leu Arg Ala Gln  Ala Glu Ala 
    1265                 1270                 1275             


Gln Gln  Pro Thr Phe Asp Ala  Leu Arg Asp Glu Leu  Arg Gly Ala 
    1280                 1285                 1290             


Gln Glu  Val Gly Glu Arg Leu  Gln Gln Arg His Gly  Glu Arg Asp 
    1295                 1300                 1305             


Val Glu  Val Glu Arg Trp Arg  Glu Arg Val Ala Gln  Leu Leu Glu 
    1310                 1315                 1320             


Arg Trp  Gln Ala Val Leu Ala  Gln Thr Asp Val Arg  Gln Arg Glu 
    1325                 1330                 1335             


Leu Glu  Gln Leu Gly Arg Gln  Leu Arg Tyr Tyr Arg  Glu Ser Ala 
    1340                 1345                 1350             


Asp Pro  Leu Gly Ala Trp Leu  Gln Asp Ala Arg Arg  Arg Gln Glu 
    1355                 1360                 1365             


Gln Ile  Gln Ala Met Pro Leu  Ala Asp Ser Gln Ala  Val Arg Glu 
    1370                 1375                 1380             


Gln Leu  Arg Gln Glu Gln Ala  Leu Leu Glu Glu Ile  Glu Arg His 
    1385                 1390                 1395             


Gly Glu  Lys Val Glu Glu Cys  Gln Arg Phe Ala Lys  Gln Tyr Ile 
    1400                 1405                 1410             


Asn Ala  Ile Lys Asp Tyr Glu  Leu Gln Leu Val Thr  Tyr Lys Ala 
    1415                 1420                 1425             


Gln Leu  Glu Pro Val Ala Ser  Pro Ala Lys Lys Pro  Lys Val Gln 
    1430                 1435                 1440             


Ser Gly  Ser Glu Ser Val Ile  Gln Glu Tyr Val Asp  Leu Arg Thr 
    1445                 1450                 1455             


His Tyr  Ser Glu Leu Thr Thr  Leu Thr Ser Gln Tyr  Ile Lys Phe 
    1460                 1465                 1470             


Ile Ser  Glu Thr Leu Arg Arg  Met Glu Glu Glu Glu  Arg Leu Ala 
    1475                 1480                 1485             


Glu Gln  Gln Arg Ala Glu Glu  Arg Glu Arg Leu Ala  Glu Val Glu 
    1490                 1495                 1500             


Ala Ala  Leu Glu Lys Gln Arg  Gln Leu Ala Glu Ala  His Ala Gln 
    1505                 1510                 1515             


Ala Lys  Ala Gln Ala Glu Arg  Glu Ala Lys Glu Leu  Gln Gln Arg 
    1520                 1525                 1530             


Met Gln  Glu Glu Val Val Arg  Arg Glu Glu Ala Ala  Val Asp Ala 
    1535                 1540                 1545             


Gln Gln  Gln Lys Arg Ser Ile  Gln Glu Glu Leu Gln  Gln Leu Arg 
    1550                 1555                 1560             


Gln Ser  Ser Glu Ala Glu Ile  Gln Ala Lys Ala Arg  Gln Ala Glu 
    1565                 1570                 1575             


Ala Ala  Glu Arg Ser Arg Leu  Arg Ile Glu Glu Glu  Ile Arg Val 
    1580                 1585                 1590             


Val Arg  Leu Gln Leu Glu Ala  Thr Glu Arg Gln Arg  Gly Gly Ala 
    1595                 1600                 1605             


Glu Gly  Glu Leu Gln Ala Leu  Arg Ala Arg Ala Glu  Glu Ala Glu 
    1610                 1615                 1620             


Ala Gln  Lys Arg Gln Ala Gln  Glu Glu Ala Glu Arg  Leu Arg Arg 
    1625                 1630                 1635             


Gln Val  Gln Asp Glu Ser Gln  Arg Lys Arg Gln Ala  Glu Val Glu 
    1640                 1645                 1650             


Leu Ala  Ser Arg Val Lys Ala  Glu Ala Glu Ala Ala  Arg Glu Lys 
    1655                 1660                 1665             


Gln Arg  Ala Leu Gln Ala Leu  Glu Glu Leu Arg Leu  Gln Ala Glu 
    1670                 1675                 1680             


Glu Ala  Glu Arg Arg Leu Arg  Gln Ala Glu Val Glu  Arg Ala Arg 
    1685                 1690                 1695             


Gln Val  Gln Val Ala Leu Glu  Thr Ala Gln Arg Ser  Ala Glu Ala 
    1700                 1705                 1710             


Glu Leu  Gln Ser Lys Arg Ala  Ser Phe Ala Glu Lys  Thr Ala Gln 
    1715                 1720                 1725             


Leu Glu  Arg Ser Leu Gln Glu  Glu His Val Ala Val  Ala Gln Leu 
    1730                 1735                 1740             


Arg Glu  Glu Ala Glu Arg Arg  Ala Gln Gln Gln Ala  Glu Ala Glu 
    1745                 1750                 1755             


Arg Ala  Arg Glu Glu Ala Glu  Arg Glu Leu Glu Arg  Trp Gln Leu 
    1760                 1765                 1770             


Lys Ala  Asn Glu Ala Leu Arg  Leu Arg Leu Gln Ala  Glu Glu Val 
    1775                 1780                 1785             


Ala Gln  Gln Lys Ser Leu Ala  Gln Ala Glu Ala Glu  Lys Gln Lys 
    1790                 1795                 1800             


Glu Glu  Ala Glu Arg Glu Ala  Arg Arg Arg Gly Lys  Ala Glu Glu 
    1805                 1810                 1815             


Gln Ala  Val Arg Gln Arg Glu  Leu Ala Glu Gln Glu  Leu Glu Lys 
    1820                 1825                 1830             


Gln Arg  Gln Leu Ala Glu Gly  Thr Ala Gln Gln Arg  Leu Ala Ala 
    1835                 1840                 1845             


Glu Gln  Glu Leu Ile Arg Leu  Arg Ala Glu Thr Glu  Gln Gly Glu 
    1850                 1855                 1860             


Gln Gln  Arg Gln Leu Leu Glu  Glu Glu Leu Ala Arg  Leu Gln Arg 
    1865                 1870                 1875             


Glu Ala  Ala Ala Ala Thr Gln  Lys Arg Gln Glu Leu  Glu Ala Glu 
    1880                 1885                 1890             


Leu Ala  Lys Val Arg Ala Glu  Met Glu Val Leu Leu  Ala Ser Lys 
    1895                 1900                 1905             


Ala Arg  Ala Glu Glu Glu Ser  Arg Ser Thr Ser Glu  Lys Ser Lys 
    1910                 1915                 1920             


Gln Arg  Leu Glu Ala Glu Ala  Gly Arg Phe Arg Glu  Leu Ala Glu 
    1925                 1930                 1935             


Glu Ala  Ala Arg Leu Arg Ala  Leu Ala Glu Glu Ala  Lys Arg Gln 
    1940                 1945                 1950             


Arg Gln  Leu Ala Glu Glu Asp  Ala Ala Arg Gln Arg  Ala Glu Ala 
    1955                 1960                 1965             


Glu Arg  Val Leu Ala Glu Lys  Leu Ala Ala Ile Gly  Glu Ala Thr 
    1970                 1975                 1980             


Arg Leu  Lys Thr Glu Ala Glu  Ile Ala Leu Lys Glu  Lys Glu Ala 
    1985                 1990                 1995             


Glu Asn  Glu Arg Leu Arg Arg  Leu Ala Glu Asp Glu  Ala Phe Gln 
    2000                 2005                 2010             


Arg Arg  Arg Leu Glu Glu Gln  Ala Ala Gln His Lys  Ala Asp Ile 
    2015                 2020                 2025             


Glu Glu  Arg Leu Ala Gln Leu  Arg Lys Ala Ser Asp  Ser Glu Leu 
    2030                 2035                 2040             


Glu Arg  Gln Lys Gly Leu Val  Glu Asp Thr Leu Arg  Gln Arg Arg 
    2045                 2050                 2055             


Gln Val  Glu Glu Glu Ile Leu  Ala Leu Lys Ala Ser  Phe Glu Lys 
    2060                 2065                 2070             


Ala Ala  Ala Gly Lys Ala Glu  Leu Glu Leu Glu Leu  Gly Arg Ile 
    2075                 2080                 2085             


Arg Ser  Asn Ala Glu Asp Thr  Leu Arg Ser Lys Glu  Gln Ala Glu 
    2090                 2095                 2100             


Leu Glu  Ala Ala Arg Gln Arg  Gln Leu Ala Ala Glu  Glu Glu Arg 
    2105                 2110                 2115             


Arg Arg  Arg Glu Ala Glu Glu  Arg Val Gln Lys Ser  Leu Ala Ala 
    2120                 2125                 2130             


Glu Glu  Glu Ala Ala Arg Gln  Arg Lys Ala Ala Leu  Glu Glu Val 
    2135                 2140                 2145             


Glu Arg  Leu Lys Ala Asn Val  Glu Glu Ala Arg Arg  Leu Arg Glu 
    2150                 2155                 2160             


Arg Ala  Glu Gln Glu Ser Ala  Arg Gln Leu Gln Leu  Ala Gln Glu 
    2165                 2170                 2175             


Ala Ala  Gln Lys Arg Leu Gln  Ala Glu Glu Lys Ala  His Ala Phe 
    2180                 2185                 2190             


Ala Val  Gln Gln Lys Glu Gln  Glu Leu Gln Gln Thr  Leu Gln Gln 
    2195                 2200                 2205             


Glu Gln  Ser Val Leu Asp Gln  Leu Arg Gly Glu Ala  Glu Ala Ala 
    2210                 2215                 2220             


Arg Arg  Ala Ala Glu Glu Ala  Glu Glu Ala Arg Val  Gln Ala Glu 
    2225                 2230                 2235             


Arg Glu  Ala Ala Gln Ala Arg  Arg Gln Val Glu Glu  Ala Glu Arg 
    2240                 2245                 2250             


Leu Lys  Gln Ser Ala Glu Glu  Gln Ala Gln Ala Arg  Ala Gln Ala 
    2255                 2260                 2265             


Gln Ala  Ala Ala Glu Lys Leu  Arg Lys Glu Ala Glu  Gln Glu Ala 
    2270                 2275                 2280             


Ala Arg  Arg Ala Gln Ala Glu  Gln Ala Ala Leu Arg  Gln Lys Gln 
    2285                 2290                 2295             


Ala Ala  Asp Ala Glu Met Glu  Lys His Lys Lys Phe  Ala Glu Gln 
    2300                 2305                 2310             


Thr Leu  Arg Gln Lys Ala Gln  Val Glu Gln Glu Leu  Thr Thr Leu 
    2315                 2320                 2325             


Arg Leu  Gln Leu Glu Glu Thr  Asp His Gln Lys Asn  Leu Leu Asp 
    2330                 2335                 2340             


Glu Glu  Leu Gln Arg Leu Lys  Ala Glu Ala Thr Glu  Ala Ala Arg 
    2345                 2350                 2355             


Gln Arg  Ser Gln Val Glu Glu  Glu Leu Phe Ser Val  Arg Val Gln 
    2360                 2365                 2370             


Met Glu  Glu Leu Ser Lys Leu  Lys Ala Arg Ile Glu  Ala Glu Asn 
    2375                 2380                 2385             


Arg Ala  Leu Ile Leu Arg Asp  Lys Asp Asn Thr Gln  Arg Phe Leu 
    2390                 2395                 2400             


Gln Glu  Glu Ala Glu Lys Met  Lys Gln Val Ala Glu  Glu Ala Ala 
    2405                 2410                 2415             


Arg Leu  Ser Val Ala Ala Gln  Glu Ala Ala Arg Leu  Arg Gln Leu 
    2420                 2425                 2430             


Ala Glu  Glu Asp Leu Ala Gln  Gln Arg Ala Leu Ala  Glu Lys Met 
    2435                 2440                 2445             


Leu Lys  Glu Lys Met Gln Ala  Val Gln Glu Ala Thr  Arg Leu Lys 
    2450                 2455                 2460             


Ala Glu  Ala Glu Leu Leu Gln  Gln Gln Lys Glu Leu  Ala Gln Glu 
    2465                 2470                 2475             


Gln Ala  Arg Arg Leu Gln Glu  Asp Lys Glu Gln Met  Ala Gln Gln 
    2480                 2485                 2490             


Leu Ala  Glu Glu Thr Gln Gly  Phe Gln Arg Thr Leu  Glu Ala Glu 
    2495                 2500                 2505             


Arg Gln  Arg Gln Leu Glu Met  Ser Ala Glu Ala Glu  Arg Leu Lys 
    2510                 2515                 2520             


Leu Arg  Val Ala Glu Met Ser  Arg Ala Gln Ala Arg  Ala Glu Glu 
    2525                 2530                 2535             


Asp Ala  Gln Arg Phe Arg Lys  Gln Ala Glu Glu Ile  Gly Glu Lys 
    2540                 2545                 2550             


Leu His  Arg Thr Glu Leu Ala  Thr Gln Glu Lys Val  Thr Leu Val 
    2555                 2560                 2565             


Gln Thr  Leu Glu Ile Gln Arg  Gln Gln Ser Asp His  Asp Ala Glu 
    2570                 2575                 2580             


Arg Leu  Arg Glu Ala Ile Ala  Glu Leu Glu Arg Glu  Lys Glu Lys 
    2585                 2590                 2595             


Leu Gln  Gln Glu Ala Lys Leu  Leu Gln Leu Lys Ser  Glu Glu Met 
    2600                 2605                 2610             


Gln Thr  Val Gln Gln Glu Gln  Leu Leu Gln Glu Thr  Gln Ala Leu 
    2615                 2620                 2625             


Gln Gln  Ser Phe Leu Ser Glu  Lys Asp Ser Leu Leu  Gln Arg Glu 
    2630                 2635                 2640             


Arg Phe  Ile Glu Gln Glu Lys  Ala Lys Leu Glu Gln  Leu Phe Gln 
    2645                 2650                 2655             


Asp Glu  Val Ala Lys Ala Gln  Gln Leu Arg Glu Glu  Gln Gln Arg 
    2660                 2665                 2670             


Gln Gln  Gln Gln Met Glu Gln  Glu Arg Gln Arg Leu  Val Ala Ser 
    2675                 2680                 2685             


Met Glu  Glu Ala Arg Arg Arg  Gln His Glu Ala Glu  Glu Gly Val 
    2690                 2695                 2700             


Arg Arg  Lys Gln Glu Glu Leu  Gln Gln Leu Glu Gln  Gln Arg Arg 
    2705                 2710                 2715             


Gln Gln  Glu Glu Leu Leu Ala  Glu Glu Asn Gln Arg  Leu Arg Glu 
    2720                 2725                 2730             


Gln Leu  Gln Leu Leu Glu Glu  Gln His Arg Ala Ala  Leu Ala His 
    2735                 2740                 2745             


Ser Glu  Glu Val Thr Ala Ser  Gln Val Ala Ala Thr  Lys Thr Leu 
    2750                 2755                 2760             


Pro Asn  Gly Arg Asp Ala Leu  Asp Gly Pro Ala Ala  Glu Ala Glu 
    2765                 2770                 2775             


Pro Glu  His Ser Phe Asp Gly  Leu Arg Arg Lys Val  Ser Ala Gln 
    2780                 2785                 2790             


Arg Leu  Gln Glu Ala Gly Ile  Leu Ser Ala Glu Glu  Leu Gln Arg 
    2795                 2800                 2805             


Leu Ala  Gln Gly His Thr Thr  Val Asp Glu Leu Ala  Arg Arg Glu 
    2810                 2815                 2820             


Asp Val  Arg His Tyr Leu Gln  Gly Arg Ser Ser Ile  Ala Gly Leu 
    2825                 2830                 2835             


Leu Leu  Lys Ala Thr Asn Glu  Lys Leu Ser Val Tyr  Ala Ala Leu 
    2840                 2845                 2850             


Gln Arg  Gln Leu Leu Ser Pro  Gly Thr Ala Leu Ile  Leu Leu Glu 
    2855                 2860                 2865             


Ala Gln  Ala Ala Ser Gly Phe  Leu Leu Asp Pro Val  Arg Asn Arg 
    2870                 2875                 2880             


Arg Leu  Thr Val Asn Glu Ala  Val Lys Glu Gly Val  Val Gly Pro 
    2885                 2890                 2895             


Glu Leu  His His Lys Leu Leu  Ser Ala Glu Arg Ala  Val Thr Gly 
    2900                 2905                 2910             


Tyr Lys  Asp Pro Tyr Thr Gly  Gln Gln Ile Ser Leu  Phe Gln Ala 
    2915                 2920                 2925             


Met Gln  Lys Gly Leu Ile Val  Arg Glu His Gly Ile  Arg Leu Leu 
    2930                 2935                 2940             


Glu Ala  Gln Ile Ala Thr Gly  Gly Val Ile Asp Pro  Val His Ser 
    2945                 2950                 2955             


His Arg  Val Pro Val Asp Val  Ala Tyr Arg Arg Gly  Tyr Phe Asp 
    2960                 2965                 2970             


Glu Glu  Met Asn Arg Val Leu  Ala Asp Pro Ser Asp  Asp Thr Lys 
    2975                 2980                 2985             


Gly Phe  Phe Asp Pro Asn Thr  His Glu Asn Leu Thr  Tyr Leu Gln 
    2990                 2995                 3000             


Leu Leu  Glu Arg Cys Val Glu  Asp Pro Glu Thr Gly  Leu Cys Leu 
    3005                 3010                 3015             


Leu Pro  Leu Thr Asp Lys Ala  Ala Lys Gly Gly Glu  Leu Val Tyr 
    3020                 3025                 3030             


Thr Asp  Ser Glu Ala Arg Asp  Val Phe Glu Lys Ala  Thr Val Ser 
    3035                 3040                 3045             


Ala Pro  Phe Gly Lys Phe Gln  Gly Lys Thr Val Thr  Ile Trp Glu 
    3050                 3055                 3060             


Ile Ile  Asn Ser Glu Tyr Phe  Thr Ala Glu Gln Arg  Arg Asp Leu 
    3065                 3070                 3075             


Leu Arg  Gln Phe Arg Thr Gly  Arg Ile Thr Val Glu  Lys Ile Ile 
    3080                 3085                 3090             


Lys Ile  Ile Ile Thr Val Val  Glu Glu Gln Glu Gln  Lys Gly Arg 
    3095                 3100                 3105             


Leu Cys  Phe Glu Gly Leu Arg  Ser Leu Val Pro Ala  Ala Glu Leu 
    3110                 3115                 3120             


Leu Glu  Ser Arg Val Ile Asp  Arg Glu Leu Tyr Gln  Gln Leu Gln 
    3125                 3130                 3135             


Arg Gly  Glu Arg Ser Val Arg  Asp Val Ala Glu Val  Asp Thr Val 
    3140                 3145                 3150             


Arg Arg  Ala Leu Arg Gly Ala  Asn Val Ile Ala Gly  Val Trp Leu 
    3155                 3160                 3165             


Glu Glu  Ala Gly Gln Lys Leu  Ser Ile Tyr Asn Ala  Leu Lys Lys 
    3170                 3175                 3180             


Asp Leu  Leu Pro Ser Asp Met  Ala Val Ala Leu Leu  Glu Ala Gln 
    3185                 3190                 3195             


Ala Gly  Thr Gly His Ile Ile  Asp Pro Ala Thr Ser  Ala Arg Leu 
    3200                 3205                 3210             


Thr Val  Asp Glu Ala Val Arg  Ala Gly Leu Val Gly  Pro Glu Phe 
    3215                 3220                 3225             


His Glu  Lys Leu Leu Ser Ala  Glu Lys Ala Val Thr  Gly Tyr Arg 
    3230                 3235                 3240             


Asp Pro  Tyr Thr Gly Gln Ser  Val Ser Leu Phe Gln  Ala Leu Lys 
    3245                 3250                 3255             


Lys Gly  Leu Ile Pro Arg Glu  Gln Gly Leu Arg Leu  Leu Asp Ala 
    3260                 3265                 3270             


Gln Leu  Ser Thr Gly Gly Ile  Val Asp Pro Ser Lys  Ser His Arg 
    3275                 3280                 3285             


Val Pro  Leu Asp Val Ala Cys  Ala Arg Gly Cys Leu  Asp Glu Glu 
    3290                 3295                 3300             


Thr Ser  Arg Ala Leu Ser Ala  Pro Arg Ala Asp Ala  Lys Ala Tyr 
    3305                 3310                 3315             


Ser Asp  Pro Ser Thr Gly Glu  Pro Ala Thr Tyr Gly  Glu Leu Gln 
    3320                 3325                 3330             


Gln Arg  Cys Arg Pro Asp Gln  Leu Thr Gly Leu Ser  Leu Leu Pro 
    3335                 3340                 3345             


Leu Ser  Glu Lys Ala Ala Arg  Ala Arg Gln Glu Glu  Leu Tyr Ser 
    3350                 3355                 3360             


Glu Leu  Gln Ala Arg Glu Thr  Phe Glu Lys Thr Pro  Val Glu Val 
    3365                 3370                 3375             


Pro Val  Gly Gly Phe Lys Gly  Arg Thr Val Thr Val  Trp Glu Leu 
    3380                 3385                 3390             


Ile Ser  Ser Glu Tyr Phe Thr  Ala Glu Gln Arg Gln  Glu Leu Leu 
    3395                 3400                 3405             


Arg Gln  Phe Arg Thr Gly Lys  Val Thr Val Glu Lys  Val Ile Lys 
    3410                 3415                 3420             


Ile Leu  Ile Thr Ile Val Glu  Glu Val Glu Thr Leu  Arg Gln Glu 
    3425                 3430                 3435             


Arg Leu  Ser Phe Ser Gly Leu  Arg Ala Pro Val Pro  Ala Ser Glu 
    3440                 3445                 3450             


Leu Leu  Ala Ser Gly Val Leu  Ser Arg Ala Gln Phe  Glu Gln Leu 
    3455                 3460                 3465             


Lys Asp  Gly Lys Thr Thr Val  Lys Asp Leu Ser Glu  Leu Gly Ser 
    3470                 3475                 3480             


Val Arg  Thr Leu Leu Gln Gly  Ser Gly Cys Leu Ala  Gly Ile Tyr 
    3485                 3490                 3495             


Leu Glu  Asp Thr Lys Glu Lys  Val Ser Ile Tyr Glu  Ala Met Arg 
    3500                 3505                 3510             


Arg Gly  Leu Leu Arg Ala Thr  Thr Ala Ala Leu Leu  Leu Glu Ala 
    3515                 3520                 3525             


Gln Ala  Ala Thr Gly Phe Leu  Val Asp Pro Val Arg  Asn Gln Arg 
    3530                 3535                 3540             


Leu Tyr  Val His Glu Ala Val  Lys Ala Gly Val Val  Gly Pro Glu 
    3545                 3550                 3555             


Leu His  Glu Gln Leu Leu Ser  Ala Glu Lys Ala Val  Thr Gly Tyr 
    3560                 3565                 3570             


Arg Asp  Pro Tyr Ser Gly Ser  Thr Ile Ser Leu Phe  Gln Ala Met 
    3575                 3580                 3585             


Gln Lys  Gly Leu Val Leu Arg  Gln His Gly Ile Arg  Leu Leu Glu 
    3590                 3595                 3600             


Ala Gln  Ile Ala Thr Gly Gly  Ile Ile Asp Pro Val  His Ser His 
    3605                 3610                 3615             


Arg Val  Pro Val Asp Val Ala  Tyr Gln Arg Gly Tyr  Phe Ser Glu 
    3620                 3625                 3630             


Glu Met  Asn Arg Val Leu Ala  Asp Pro Ser Asp Asp  Thr Lys Gly 
    3635                 3640                 3645             


Phe Phe  Asp Pro Asn Thr His  Glu Asn Leu Thr Tyr  Arg Gln Leu 
    3650                 3655                 3660             


Leu Glu  Arg Cys Val Glu Asp  Pro Glu Thr Gly Leu  Arg Leu Leu 
    3665                 3670                 3675             


Pro Leu  Lys Gly Ala Glu Lys  Ala Glu Val Val Glu  Thr Thr Gln 
    3680                 3685                 3690             


Val Tyr  Thr Glu Glu Glu Thr  Arg Arg Ala Phe Glu  Glu Thr Gln 
    3695                 3700                 3705             


Ile Asp  Ile Pro Gly Gly Gly  Ser His Gly Gly Ser  Thr Met Ser 
    3710                 3715                 3720             


Leu Trp  Glu Val Met Gln Ser  Asp Leu Ile Pro Glu  Glu Gln Arg 
    3725                 3730                 3735             


Ala Gln  Leu Met Ala Asp Phe  Gln Ala Gly Arg Val  Thr Lys Glu 
    3740                 3745                 3750             


Arg Met  Ile Ile Ile Ile Ile  Glu Ile Ile Glu Lys  Thr Glu Ile 
    3755                 3760                 3765             


Ile Arg  Gln Gln Gly Leu Ala  Ser Tyr Asp Tyr Val  Arg Arg Arg 
    3770                 3775                 3780             


Leu Thr  Ala Glu Asp Leu Phe  Glu Ala Arg Ile Ile  Ser Leu Glu 
    3785                 3790                 3795             


Thr Tyr  Asn Leu Leu Arg Glu  Gly Thr Arg Ser Leu  Arg Glu Ala 
    3800                 3805                 3810             


Leu Glu  Ala Glu Ser Ala Trp  Cys Tyr Leu Tyr Gly  Thr Gly Ser 
    3815                 3820                 3825             


Val Ala  Gly Val Tyr Leu Pro  Gly Ser Arg Gln Thr  Leu Ser Ile 
    3830                 3835                 3840             


Tyr Gln  Ala Leu Lys Lys Gly  Leu Leu Ser Ala Glu  Val Ala Arg 
    3845                 3850                 3855             


Leu Leu  Leu Glu Ala Gln Ala  Ala Thr Gly Phe Leu  Leu Asp Pro 
    3860                 3865                 3870             


Val Lys  Gly Glu Arg Leu Thr  Val Asp Glu Ala Val  Arg Lys Gly 
    3875                 3880                 3885             


Leu Val  Gly Pro Glu Leu His  Asp Arg Leu Leu Ser  Ala Glu Arg 
    3890                 3895                 3900             


Ala Val  Thr Gly Tyr Arg Asp  Pro Tyr Thr Glu Gln  Thr Ile Ser 
    3905                 3910                 3915             


Leu Phe  Gln Ala Met Lys Lys  Glu Leu Ile Pro Thr  Glu Glu Ala 
    3920                 3925                 3930             


Leu Arg  Leu Leu Asp Ala Gln  Leu Ala Thr Gly Gly  Ile Val Asp 
    3935                 3940                 3945             


Pro Arg  Leu Gly Phe His Leu  Pro Leu Glu Val Ala  Tyr Gln Arg 
    3950                 3955                 3960             


Gly Tyr  Leu Asn Lys Asp Thr  His Asp Gln Leu Ser  Glu Pro Ser 
    3965                 3970                 3975             


Glu Val  Arg Ser Tyr Val Asp  Pro Ser Thr Asp Glu  Arg Leu Ser 
    3980                 3985                 3990             


Tyr Thr  Gln Leu Leu Arg Arg  Cys Arg Arg Asp Asp  Gly Thr Gly 
    3995                 4000                 4005             


Gln Leu  Leu Leu Pro Leu Ser  Asp Ala Arg Lys Leu  Thr Phe Arg 
    4010                 4015                 4020             


Gly Leu  Arg Lys Gln Ile Thr  Met Glu Glu Leu Val  Arg Ser Gln 
    4025                 4030                 4035             


Val Met  Asp Glu Ala Thr Ala  Leu Gln Leu Arg Glu  Gly Leu Thr 
    4040                 4045                 4050             


Ser Ile  Glu Glu Val Thr Lys  Asn Leu Gln Lys Phe  Leu Glu Gly 
    4055                 4060                 4065             


Thr Ser  Cys Ile Ala Gly Val  Phe Val Asp Ala Thr  Lys Glu Arg 
    4070                 4075                 4080             


Leu Ser  Val Tyr Gln Ala Met  Lys Lys Gly Ile Ile  Arg Pro Gly 
    4085                 4090                 4095             


Thr Ala  Phe Glu Leu Leu Glu  Ala Gln Ala Ala Thr  Gly Tyr Val 
    4100                 4105                 4110             


Ile Asp  Pro Ile Lys Gly Leu  Lys Leu Thr Val Glu  Glu Ala Val 
    4115                 4120                 4125             


Arg Met  Gly Ile Val Gly Pro  Glu Phe Lys Asp Lys  Leu Leu Ser 
    4130                 4135                 4140             


Ala Glu  Arg Ala Val Thr Gly  Tyr Lys Asp Pro Tyr  Ser Gly Lys 
    4145                 4150                 4155             


Leu Ile  Ser Leu Phe Gln Ala  Met Lys Lys Gly Leu  Ile Leu Lys 
    4160                 4165                 4170             


Asp His  Gly Ile Arg Leu Leu  Glu Ala Gln Ile Ala  Thr Gly Gly 
    4175                 4180                 4185             


Ile Ile  Asp Pro Glu Glu Ser  His Arg Leu Pro Val  Glu Val Ala 
    4190                 4195                 4200             


Tyr Lys  Arg Gly Leu Phe Asp  Glu Glu Met Asn Glu  Ile Leu Thr 
    4205                 4210                 4215             


Asp Pro  Ser Asp Asp Thr Lys  Gly Phe Phe Asp Pro  Asn Thr Glu 
    4220                 4225                 4230             


Glu Asn  Leu Thr Tyr Leu Gln  Leu Met Glu Arg Cys  Ile Thr Asp 
    4235                 4240                 4245             


Pro Gln  Thr Gly Leu Cys Leu  Leu Pro Leu Lys Glu  Lys Lys Arg 
    4250                 4255                 4260             


Glu Arg  Lys Thr Ser Ser Lys  Ser Ser Val Arg Lys  Arg Arg Val 
    4265                 4270                 4275             


Val Ile  Val Asp Pro Glu Thr  Gly Lys Glu Met Ser  Val Tyr Glu 
    4280                 4285                 4290             


Ala Tyr  Arg Lys Gly Leu Ile  Asp His Gln Thr Tyr  Leu Glu Leu 
    4295                 4300                 4305             


Ser Glu  Gln Glu Cys Glu Trp  Glu Glu Ile Thr Ile  Ser Ser Ser 
    4310                 4315                 4320             


Asp Gly  Val Val Lys Ser Met  Ile Ile Asp Arg Arg  Ser Gly Arg 
    4325                 4330                 4335             


Gln Tyr  Asp Ile Asp Asp Ala  Ile Ala Lys Asn Leu  Ile Asp Arg 
    4340                 4345                 4350             


Ser Ala  Leu Asp Gln Tyr Arg  Ala Gly Thr Leu Ser  Ile Thr Glu 
    4355                 4360                 4365             


Phe Ala  Asp Met Leu Ser Gly  Asn Ala Gly Gly Phe  Arg Ser Arg 
    4370                 4375                 4380             


Ser Ser  Ser Val Gly Ser Ser  Ser Ser Tyr Pro Ile  Ser Pro Ala 
    4385                 4390                 4395             


Val Ser  Arg Thr Gln Leu Ala  Ser Trp Ser Asp Pro  Thr Glu Glu 
    4400                 4405                 4410             


Thr Gly  Pro Val Ala Gly Ile  Leu Asp Thr Glu Thr  Leu Glu Lys 
    4415                 4420                 4425             


Val Ser  Ile Thr Glu Ala Met  His Arg Asn Leu Val  Asp Asn Ile 
    4430                 4435                 4440             


Thr Gly  Gln Arg Leu Leu Glu  Ala Gln Ala Cys Thr  Gly Gly Ile 
    4445                 4450                 4455             


Ile Asp  Pro Ser Thr Gly Glu  Arg Phe Pro Val Thr  Asp Ala Val 
    4460                 4465                 4470             


Asn Lys  Gly Leu Val Asp Lys  Ile Met Val Asp Arg  Ile Asn Leu 
    4475                 4480                 4485             


Ala Gln  Lys Ala Phe Cys Gly  Phe Glu Asp Pro Arg  Thr Lys Thr 
    4490                 4495                 4500             


Lys Met  Ser Ala Ala Gln Ala  Leu Lys Lys Gly Trp  Leu Tyr Tyr 
    4505                 4510                 4515             


Glu Ala  Gly Gln Arg Phe Leu  Glu Val Gln Tyr Leu  Thr Gly Gly 
    4520                 4525                 4530             


Leu Ile  Glu Pro Asp Thr Pro  Gly Arg Val Pro Leu  Asp Glu Ala 
    4535                 4540                 4545             


Leu Gln  Arg Gly Thr Val Asp  Ala Arg Thr Ala Gln  Lys Leu Arg 
    4550                 4555                 4560             


Asp Val  Gly Ala Tyr Ser Lys  Tyr Leu Thr Cys Pro  Lys Thr Lys 
    4565                 4570                 4575             


Leu Lys  Ile Ser Tyr Lys Asp  Ala Leu Asp Arg Ser  Met Val Glu 
    4580                 4585                 4590             


Glu Gly  Thr Gly Leu Arg Leu  Leu Glu Ala Ala Ala  Gln Ser Thr 
    4595                 4600                 4605             


Lys Gly  Tyr Tyr Ser Pro Tyr  Ser Val Ser Gly Ser  Gly Ser Thr 
    4610                 4615                 4620             


Ala Gly  Ser Arg Thr Gly Ser  Arg Thr Gly Ser Arg  Ala Gly Ser 
    4625                 4630                 4635             


Arg Arg  Gly Ser Phe Asp Ala  Thr Gly Ser Gly Phe  Ser Met Thr 
    4640                 4645                 4650             


Phe Ser  Ser Ser Ser Tyr Ser  Ser Ser Gly Tyr Gly  Arg Arg Tyr 
    4655                 4660                 4665             


Ala Ser  Gly Ser Ser Ala Ser  Leu Gly Gly Pro Glu  Ser Ala Val 
    4670                 4675                 4680             


Ala 
    


<210>  196
<211>  4074
<212>  PRT
<213>  homo sapiens

<400>  196

Met Thr Ala Trp Leu Ile Ser Leu Met Ser Ile Glu Val Leu Leu Leu 
1               5                   10                  15      


Ala Val Arg His Leu Ser Leu His Ile Glu Pro Glu Glu Gly Ser Leu 
            20                  25                  30          


Ala Gly Gly Thr Trp Ile Thr Val Ile Phe Asp Gly Leu Glu Leu Gly 
        35                  40                  45              


Val Leu Tyr Pro Asn Asn Gly Ser Gln Leu Glu Ile His Leu Val Asn 
    50                  55                  60                  


Val Asn Met Val Val Pro Ala Leu Arg Ser Val Pro Cys Asp Val Phe 
65                  70                  75                  80  


Pro Val Phe Leu Asp Leu Pro Val Val Thr Cys Arg Thr Arg Ser Val 
                85                  90                  95      


Leu Ser Glu Ala His Glu Gly Leu Tyr Phe Leu Glu Ala Tyr Phe Gly 
            100                 105                 110         


Gly Gln Leu Val Ser Ser Pro Asn Pro Gly Pro Arg Asp Ser Cys Thr 
        115                 120                 125             


Phe Lys Phe Ser Lys Ala Gln Thr Pro Ile Val His Gln Val Tyr Pro 
    130                 135                 140                 


Pro Ser Gly Val Pro Gly Lys Leu Ile His Val Tyr Gly Trp Ile Ile 
145                 150                 155                 160 


Thr Gly Arg Leu Glu Thr Phe Asp Phe Asp Ala Glu Tyr Ile Asp Ser 
                165                 170                 175     


Pro Val Ile Leu Glu Ala Gln Gly Asp Lys Trp Val Thr Pro Cys Ser 
            180                 185                 190         


Leu Ile Asn Arg Gln Met Gly Ser Cys Tyr Pro Ile Gln Glu Asp His 
        195                 200                 205             


Gly Leu Gly Thr Leu Gln Cys His Val Glu Gly Asp Tyr Ile Gly Ser 
    210                 215                 220                 


Gln Asn Val Ser Phe Ser Val Phe Asn Lys Gly Lys Ser Met Val His 
225                 230                 235                 240 


Lys Lys Ala Trp Leu Ile Ser Ala Lys Gln Asp Leu Phe Leu Tyr Gln 
                245                 250                 255     


Thr His Ser Glu Ile Leu Ser Val Phe Pro Glu Thr Gly Ser Leu Gly 
            260                 265                 270         


Gly Arg Thr Asn Ile Thr Ile Thr Gly Asp Phe Phe Asp Asn Ser Ala 
        275                 280                 285             


Gln Val Thr Ile Ala Gly Ile Pro Cys Asp Ile Arg His Val Ser Pro 
    290                 295                 300                 


Arg Lys Ile Glu Cys Thr Thr Arg Ala Pro Gly Lys Asp Val Arg Leu 
305                 310                 315                 320 


Thr Thr Pro Gln Pro Gly Asn Arg Gly Leu Leu Phe Glu Val Gly Asp 
                325                 330                 335     


Ala Val Glu Gly Leu Glu Leu Thr Glu Ala Thr Pro Gly Tyr Arg Trp 
            340                 345                 350         


Gln Ile Val Pro Asn Ala Ser Ser Pro Phe Gly Phe Trp Ser Gln Glu 
        355                 360                 365             


Gly Gln Pro Phe Arg Ala Arg Leu Ser Gly Phe Phe Val Ala Pro Glu 
    370                 375                 380                 


Thr Asn Asn Tyr Thr Phe Trp Ile Gln Ala Asp Ser Gln Ala Ser Leu 
385                 390                 395                 400 


His Phe Ser Trp Ser Glu Glu Pro Arg Thr Lys Val Lys Val Ala Ser 
                405                 410                 415     


Ile Ser Val Gly Thr Ala Asp Trp Phe Asp Ser Trp Glu Gln Asn Arg 
            420                 425                 430         


Asp Glu Gly Thr Trp Gln Gln Lys Thr Pro Lys Leu Glu Leu Leu Gly 
        435                 440                 445             


Gly Ala Met Tyr Tyr Leu Glu Ala Glu His His Gly Ile Ala Pro Ser 
    450                 455                 460                 


Arg Gly Met Arg Ile Gly Val Gln Ile His Asn Thr Trp Leu Asn Pro 
465                 470                 475                 480 


Asp Val Val Thr Thr Tyr Leu Arg Glu Lys His Gln Ile Arg Val Arg 
                485                 490                 495     


Ala Gln Arg Leu Pro Glu Val Gln Val Leu Asn Val Ser Gly Arg Gly 
            500                 505                 510         


Asn Phe Phe Leu Thr Trp Asp Asn Val Ser Ser Gln Pro Ile Pro Ala 
        515                 520                 525             


Asn Ala Thr Ala His Leu Ile Gln Thr Thr Ile Glu Glu Leu Leu Ala 
    530                 535                 540                 


Val Lys Cys Lys Leu Glu Pro Leu Trp Ser Asn Ile Leu Leu Arg Leu 
545                 550                 555                 560 


Gly Phe Glu Arg Gly Pro Glu Val Ser Asn Ser Asp Gly Asp Leu Thr 
                565                 570                 575     


Ser Gly Thr Glu Pro Phe Cys Gly Arg Phe Ser Leu Arg Gln Pro Arg 
            580                 585                 590         


His Leu Val Leu Thr Pro Pro Ala Ala Gln Lys Gly Tyr Arg Leu Asp 
        595                 600                 605             


Gln Tyr Thr His Leu Cys Leu Ala Tyr Lys Gly His Met Asn Lys Ile 
    610                 615                 620                 


Leu Lys Met Ile Val Ser Phe Thr Ile Gly Phe Gln Asn Met Val Lys 
625                 630                 635                 640 


Asn Thr Thr Cys Asp Trp Ser Leu Thr Arg Thr Ser Pro Glu Ser Trp 
                645                 650                 655     


Gln Phe Asp Cys Thr Asp Leu Trp Glu Thr Cys Val Arg Cys Phe Gly 
            660                 665                 670         


Asp Leu Gln Pro Pro Pro Ala Asn Ser Pro Val Leu Val His Gln Ile 
        675                 680                 685             


Asn Leu Leu Pro Leu Ala Gln Glu Thr Gly Leu Phe Tyr Val Asp Glu 
    690                 695                 700                 


Ile Ile Ile Ala Asp Thr Asn Val Thr Val Ser Gln Ala Asp Ser Gly 
705                 710                 715                 720 


Thr Ala Arg Pro Gly Gly Asn Leu Val Glu Ser Val Ser Val Val Gly 
                725                 730                 735     


Ser Pro Pro Val Tyr Ser Val Thr Ser Trp Leu Ala Gly Cys Gly Thr 
            740                 745                 750         


Glu Leu Pro Leu Ile Thr Ala Arg Ser Val Pro Thr Glu Gly Thr Glu 
        755                 760                 765             


Glu Gly Ser Gly Leu Val Leu Val Thr Thr Gln Arg Arg Gln Arg Thr 
    770                 775                 780                 


Ser Pro Pro Leu Gly Gly His Phe Arg Ile Gln Leu Pro Asn Thr Val 
785                 790                 795                 800 


Ile Ser Asp Val Pro Val Gln Ile Ser Ala His His Leu His Gln Leu 
                805                 810                 815     


Leu Gln Asn Asn Ala Asp Asp Phe Thr Ser Arg Tyr Leu Asn Ala Ser 
            820                 825                 830         


Asp Phe Thr Val Lys Glu Asp Leu Tyr Thr Cys Tyr Glu His Val Trp 
        835                 840                 845             


Thr Leu Ser Trp Ser Thr Gln Ile Gly Asp Leu Pro Asn Phe Ile Arg 
    850                 855                 860                 


Val Ser Asp Glu Asn Leu Thr Gly Val Asn Pro Ala Ala Ala Thr Arg 
865                 870                 875                 880 


Val Val Tyr Asp Gly Gly Val Phe Leu Gly Pro Ile Phe Gly Asp Met 
                885                 890                 895     


Leu Ala Thr Ala Asn Gln His Thr Gln Val Val Val Arg Val Asn Asp 
            900                 905                 910         


Val Pro Ala His Cys Pro Gly Ser Cys Ser Phe Gln Tyr Leu Gln Gly 
        915                 920                 925             


Ser Thr Pro Cys Val His Ser Val Trp Tyr Ser Ile Asp Gly Asp Ile 
    930                 935                 940                 


Asn Leu Met Ile Tyr Ile Thr Gly Thr Gly Phe Ser Gly Asp Ser Gln 
945                 950                 955                 960 


Phe Leu Gln Val Thr Val Asn Lys Thr Ser Cys Lys Val Ile Phe Ser 
                965                 970                 975     


Asn Gln Thr Asn Val Val Cys Gln Thr Asp Leu Leu Pro Val Gly Met 
            980                 985                 990         


His Arg Ile Leu Met Leu Val Arg  Pro Ser Gly Leu Ala  Ile Ser Ala 
        995                 1000                 1005             


Thr Gly  Glu Asp Leu Phe Leu  Asn Val Lys Pro Arg  Leu Asp Met 
    1010                 1015                 1020             


Val Glu  Pro Ser Arg Ala Ala  Asp Ile Gly Gly Leu  Trp Ala Thr 
    1025                 1030                 1035             


Ile Arg  Gly Ser Ser Leu Glu  Gly Val Ser Leu Ile  Leu Phe Gly 
    1040                 1045                 1050             


Ser Tyr  Ser Cys Ala Ile Asn  Val Ala Thr Ser Asn  Ser Ser Arg 
    1055                 1060                 1065             


Ile Gln  Cys Lys Val Pro Pro  Arg Gly Lys Asp Gly  Arg Ile Val 
    1070                 1075                 1080             


Asn Val  Thr Val Ile Arg Gly  Asp Tyr Ser Ala Val  Leu Pro Arg 
    1085                 1090                 1095             


Ala Phe  Thr Tyr Val Ser Ser  Leu Asn Pro Val Ile  Val Thr Leu 
    1100                 1105                 1110             


Ser Arg  Asn Ile Ser Asn Ile  Ala Gly Gly Glu Thr  Leu Val Ile 
    1115                 1120                 1125             


Gly Val  Ala Arg Leu Met Asn  Tyr Thr Asp Leu Asp  Val Glu Val 
    1130                 1135                 1140             


His Val  Gln Asp Ala Leu Ala  Pro Val His Thr Gln  Ser Ala Trp 
    1145                 1150                 1155             


Gly Leu  Glu Val Ala Leu Pro  Pro Leu Pro Ala Gly  Leu His Arg 
    1160                 1165                 1170             


Ile Ser  Val Ser Ile Asn Gly  Val Ser Ile His Ser  Gln Gly Val 
    1175                 1180                 1185             


Asp Leu  His Ile Gln Tyr Leu  Thr Glu Val Phe Ser  Ile Glu Pro 
    1190                 1195                 1200             


Cys Cys  Gly Ser Leu Leu Gly  Gly Thr Ile Leu Ser  Ile Ser Gly 
    1205                 1210                 1215             


Ile Gly  Phe Ser Arg Asp Pro  Ala Leu Val Trp Val  Leu Val Gly 
    1220                 1225                 1230             


Asn Arg  Ser Cys Asp Ile Val  Asn Leu Thr Glu Ala  Ser Ile Trp 
    1235                 1240                 1245             


Cys Glu  Thr Leu Pro Ala Pro  Gln Ile Pro Asp Ala  Gly Ala Pro 
    1250                 1255                 1260             


Thr Val  Pro Ala Ala Val Glu  Val Trp Ala Gly Asn  Arg Phe Phe 
    1265                 1270                 1275             


Ala Arg  Gly Pro Ser Pro Ser  Leu Val Gly Lys Gly  Phe Thr Phe 
    1280                 1285                 1290             


Met Tyr  Glu Ala Ala Ala Thr  Pro Val Val Thr Ala  Met Gln Gly 
    1295                 1300                 1305             


Glu Ile  Thr Asn Ser Ser Leu  Ser Leu His Val Gly  Gly Ser Asn 
    1310                 1315                 1320             


Leu Ser  Asn Ser Val Ile Leu  Leu Gly Asn Leu Asn  Cys Asp Val 
    1325                 1330                 1335             


Glu Thr  Gln Ser Phe Gln Gly  Asn Val Ser Leu Ser  Gly Cys Ser 
    1340                 1345                 1350             


Ile Pro  Leu His Ser Leu Glu  Ala Gly Ile Tyr Pro  Leu Gln Val 
    1355                 1360                 1365             


Arg Gln  Lys Gln Met Gly Phe  Ala Asn Met Ser Val  Val Leu Gln 
    1370                 1375                 1380             


Gln Phe  Ala Val Met Pro Arg  Ile Met Ala Ile Phe  Pro Ser Gln 
    1385                 1390                 1395             


Gly Ser  Ala Cys Gly Gly Thr  Ile Leu Thr Val Arg  Gly Leu Leu 
    1400                 1405                 1410             


Leu Asn  Ser Arg Arg Arg Ser  Val Arg Val Asp Leu  Ser Gly Pro 
    1415                 1420                 1425             


Phe Thr  Cys Val Ile Leu Ser  Leu Gly Asp His Thr  Ile Leu Cys 
    1430                 1435                 1440             


Gln Val  Ser Leu Glu Gly Asp  Pro Leu Pro Gly Ala  Ser Phe Ser 
    1445                 1450                 1455             


Leu Asn  Val Thr Val Leu Val  Asn Gly Leu Thr Ser  Glu Cys Gln 
    1460                 1465                 1470             


Gly Asn  Cys Thr Leu Phe Ile  Arg Glu Glu Ala Ser  Pro Val Met 
    1475                 1480                 1485             


Asp Ala  Leu Ser Thr Asn Thr  Ser Gly Ser Leu Thr  Thr Val Leu 
    1490                 1495                 1500             


Ile Arg  Gly Gln Arg Leu Ala  Thr Thr Ala Asp Glu  Pro Met Val 
    1505                 1510                 1515             


Phe Val  Asp Asp Gln Leu Pro  Cys Asn Val Thr Phe  Phe Asn Ala 
    1520                 1525                 1530             


Ser His  Val Val Cys Gln Thr  Arg Asp Leu Ala Pro  Gly Pro His 
    1535                 1540                 1545             


Tyr Leu  Ser Val Phe Tyr Thr  Arg Asn Gly Tyr Ala  Cys Ser Gly 
    1550                 1555                 1560             


Asn Val  Ser Arg His Phe Tyr  Ile Met Pro Gln Val  Phe His Tyr 
    1565                 1570                 1575             


Phe Pro  Lys Asn Phe Ser Leu  His Gly Gly Ser Leu  Leu Thr Ile 
    1580                 1585                 1590             


Glu Gly  Thr Gly Leu Arg Gly  Gln Asn Thr Thr Ser  Val Tyr Ile 
    1595                 1600                 1605             


Asp Gln  Gln Thr Cys Leu Thr  Val Asn Ile Gly Ala  Glu Leu Ile 
    1610                 1615                 1620             


Arg Cys  Ile Val Pro Thr Gly  Asn Gly Ser Val Ala  Leu Glu Ile 
    1625                 1630                 1635             


Glu Val  Asp Gly Leu Trp Tyr  His Ile Gly Val Ile  Gly Tyr Asn 
    1640                 1645                 1650             


Lys Ala  Phe Thr Pro Glu Leu  Ile Ser Ile Ser Gln  Ser Asp Asp 
    1655                 1660                 1665             


Ile Leu  Thr Phe Ala Val Ala  Gln Ile Ser Gly Ala  Ala Asn Ile 
    1670                 1675                 1680             


Asp Ile  Phe Ile Gly Met Ser  Pro Cys Val Gly Val  Ser Gly Asn 
    1685                 1690                 1695             


His Thr  Val Leu Gln Cys Val  Val Pro Ser Leu Pro  Ala Gly Glu 
    1700                 1705                 1710             


Tyr His  Val Arg Gly Tyr Asp  Cys Ile Arg Gly Trp  Ala Ser Ser 
    1715                 1720                 1725             


Ala Leu  Val Phe Thr Ser Arg  Val Ile Ile Thr Ala  Val Thr Glu 
    1730                 1735                 1740             


Asn Phe  Gly Cys Leu Gly Gly  Arg Leu Val His Val  Phe Gly Ala 
    1745                 1750                 1755             


Gly Phe  Ser Pro Gly Asn Val  Ser Ala Ala Val Cys  Gly Ala Pro 
    1760                 1765                 1770             


Cys Arg  Val Leu Ala Asn Ala  Thr Val Ser Ala Phe  Ser Cys Leu 
    1775                 1780                 1785             


Val Leu  Pro Leu Asp Val Ser  Leu Ala Phe Leu Cys  Gly Leu Lys 
    1790                 1795                 1800             


Arg Glu  Glu Asp Ser Cys Glu  Ala Ala Arg His Thr  Tyr Val Gln 
    1805                 1810                 1815             


Cys Asp  Leu Thr Val Ala Met  Ala Thr Glu Gln Leu  Leu Glu Ser 
    1820                 1825                 1830             


Trp Pro  Tyr Leu Tyr Ile Cys  Glu Glu Ser Ser Gln  Cys Leu Phe 
    1835                 1840                 1845             


Val Pro  Asp His Trp Ala Glu  Ser Met Phe Pro Ser  Phe Ser Gly 
    1850                 1855                 1860             


Leu Phe  Ile Ser Pro Lys Leu  Glu Arg Asp Glu Val  Leu Ile Tyr 
    1865                 1870                 1875             


Asn Ser  Ser Cys Asn Ile Thr  Met Glu Thr Glu Ala  Glu Met Glu 
    1880                 1885                 1890             


Cys Glu  Thr Pro Asn Gln Pro  Ile Thr Val Lys Ile  Thr Glu Ile 
    1895                 1900                 1905             


Arg Lys  Arg Trp Gly Gln Asn  Thr Gln Gly Asn Phe  Ser Leu Gln 
    1910                 1915                 1920             


Phe Cys  Arg Arg Trp Ser Arg  Thr His Ser Trp Phe  Pro Glu Arg 
    1925                 1930                 1935             


Leu Pro  Gln Asp Gly Asp Asn  Val Thr Val Glu Asn  Gly Gln Leu 
    1940                 1945                 1950             


Leu Leu  Leu Asp Thr Asn Thr  Ser Ile Leu Asn Leu  Leu His Ile 
    1955                 1960                 1965             


Lys Gly  Gly Lys Leu Ile Phe  Met Ala Pro Gly Pro  Ile Glu Leu 
    1970                 1975                 1980             


Arg Ala  His Ala Ile Leu Val  Ser Asp Gly Gly Glu  Leu Arg Ile 
    1985                 1990                 1995             


Gly Ser  Glu Asp Lys Pro Phe  Gln Gly Arg Ala Gln  Ile Thr Leu 
    2000                 2005                 2010             


Tyr Gly  Ser Ser Tyr Ser Thr  Pro Phe Phe Pro Tyr  Gly Val Lys 
    2015                 2020                 2025             


Phe Leu  Ala Val Arg Asn Gly  Thr Leu Ser Leu His  Gly Ser Leu 
    2030                 2035                 2040             


Pro Glu  Val Ile Val Thr Cys  Leu Arg Ala Thr Ala  His Ala Leu 
    2045                 2050                 2055             


Asp Thr  Val Leu Ala Leu Glu  Asp Ala Val Asp Trp  Asn Pro Gly 
    2060                 2065                 2070             


Asp Glu  Val Val Ile Ile Ser  Gly Thr Gly Val Lys  Gly Ala Lys 
    2075                 2080                 2085             


Pro Met  Glu Glu Ile Val Thr  Val Glu Thr Val Gln  Asp Thr Asp 
    2090                 2095                 2100             


Leu Tyr  Leu Lys Ser Pro Leu  Arg Tyr Ser His Asn  Phe Thr Glu 
    2105                 2110                 2115             


Asn Trp  Val Ala Gly Glu His  His Ile Leu Lys Ala  Thr Val Ala 
    2120                 2125                 2130             


Leu Leu  Ser Arg Ser Ile Thr  Ile Gln Gly Asn Leu  Thr Asn Glu 
    2135                 2140                 2145             


Arg Glu  Lys Leu Leu Val Ser  Cys Gln Glu Ala Asn  Ala Pro Glu 
    2150                 2155                 2160             


Gly Asn  Leu Gln His Cys Leu  Tyr Ser Met Ser Glu  Lys Met Leu 
    2165                 2170                 2175             


Gly Ser  Arg Asp Met Gly Ala  Arg Val Ile Val Gln  Ser Phe Pro 
    2180                 2185                 2190             


Glu Glu  Pro Ser Gln Val Gln  Leu Lys Gly Val Gln  Phe Gln Val 
    2195                 2200                 2205             


Leu Gly  Gln Ala Phe His Lys  His Leu Ser Ser Leu  Thr Leu Val 
    2210                 2215                 2220             


Gly Ala  Met Arg Glu Ser Phe  Ile Gln Gly Cys Thr  Val Arg Asn 
    2225                 2230                 2235             


Ser Phe  Ser Arg Gly Leu Ser  Met Cys Gly Thr Leu  Gly Leu Lys 
    2240                 2245                 2250             


Val Asp  Ser Asn Val Phe Tyr  Asn Ile Leu Gly His  Ala Leu Leu 
    2255                 2260                 2265             


Val Gly  Thr Cys Thr Glu Met  Arg Tyr Ile Ser Trp  Glu Ala Ile 
    2270                 2275                 2280             


His Gly  Arg Lys Asp Asp Trp  Ser Gly His Gly Asn  Ile Ile Arg 
    2285                 2290                 2295             


Asn Asn  Val Ile Ile Gln Val  Ser Gly Ala Glu Gly  Leu Ser Asn 
    2300                 2305                 2310             


Pro Glu  Met Leu Thr Pro Ser  Gly Ile Tyr Ile Cys  Ser Pro Thr 
    2315                 2320                 2325             


Asn Val  Ile Glu Gly Asn Arg  Val Cys Gly Ala Gly  Tyr Gly Tyr 
    2330                 2335                 2340             


Phe Phe  His Leu Met Thr Asn  Gln Thr Ser Gln Ala  Pro Leu Leu 
    2345                 2350                 2355             


Ser Phe  Thr Gln Asn Ile Ala  His Ser Cys Thr Arg  Tyr Gly Leu 
    2360                 2365                 2370             


Phe Val  Tyr Pro Lys Phe Gln  Pro Pro Trp Asp Asn  Val Thr Gly 
    2375                 2380                 2385             


Thr Thr  Leu Phe Gln Ser Phe  Thr Val Trp Glu Ser  Ala Gly Gly 
    2390                 2395                 2400             


Ala Gln  Ile Phe Arg Ser Ser  Asn Leu Arg Leu Lys  Asn Phe Lys 
    2405                 2410                 2415             


Val Tyr  Ser Cys Arg Asp Phe  Gly Ile Asp Val Leu  Glu Ser Asp 
    2420                 2425                 2430             


Ala Asn  Thr Ser Val Thr Asp  Ser Leu Leu Leu Gly  His Phe Ala 
    2435                 2440                 2445             


His Lys  Gly Ser Leu Cys Met  Ser Ser Gly Ile Lys  Thr Pro Lys 
    2450                 2455                 2460             


Arg Trp  Glu Leu Met Val Ser  Asn Thr Thr Phe Val  Asn Phe Asp 
    2465                 2470                 2475             


Leu Ile  Asn Cys Val Ala Ile  Arg Thr Cys Ser Asp  Cys Ser Gln 
    2480                 2485                 2490             


Gly Gln  Gly Gly Phe Thr Val  Lys Thr Ser Gln Leu  Lys Phe Thr 
    2495                 2500                 2505             


Asn Ser  Ser Asn Leu Val Ala  Phe Pro Phe Pro His  Ala Ala Ile 
    2510                 2515                 2520             


Leu Glu  Asp Leu Asp Gly Ser  Leu Ser Gly Lys Asn  Arg Ser His 
    2525                 2530                 2535             


Ile Leu  Ala Ser Met Glu Thr  Leu Ser Ala Ser Cys  Leu Val Asn 
    2540                 2545                 2550             


Ser Ser  Phe Gly Arg Val Val  His Gly Ser Ala Cys  Gly Gly Gly 
    2555                 2560                 2565             


Val Leu  Phe His Arg Met Ser  Ile Gly Leu Ala Asn  Thr Pro Glu 
    2570                 2575                 2580             


Val Ser  Tyr Asp Leu Thr Met  Thr Asp Ser Arg Asn  Lys Thr Thr 
    2585                 2590                 2595             


Thr Val  Asn Tyr Val Arg Asp  Thr Leu Ser Asn Pro  Arg Gly Trp 
    2600                 2605                 2610             


Met Ala  Leu Leu Leu Asp Gln  Glu Thr Tyr Ser Leu  Gln Ser Glu 
    2615                 2620                 2625             


Asn Leu  Trp Ile Asn Arg Ser  Leu Gln Tyr Ser Ala  Thr Phe Asp 
    2630                 2635                 2640             


Asn Phe  Ala Pro Gly Asn Tyr  Leu Leu Leu Val His  Thr Asp Leu 
    2645                 2650                 2655             


Pro Pro  Tyr Pro Asp Ile Leu  Leu Arg Cys Gly Ser  Arg Val Gly 
    2660                 2665                 2670             


Leu Ser  Phe Pro Phe Leu Pro  Ser Pro Gly Gln Asn  Gln Gly Cys 
    2675                 2680                 2685             


Asp Trp  Phe Phe Asn Ser Gln  Leu Arg Gln Leu Thr  Tyr Leu Val 
    2690                 2695                 2700             


Ser Gly  Glu Gly Gln Val Gln  Val Ile Leu Arg Val  Lys Glu Gly 
    2705                 2710                 2715             


Met Pro  Pro Thr Ile Ser Ala  Ser Thr Ser Ala Pro  Glu Ser Ala 
    2720                 2725                 2730             


Leu Lys  Trp Ser Leu Pro Glu  Thr Trp Gln Gly Val  Glu Glu Gly 
    2735                 2740                 2745             


Trp Gly  Gly Tyr Asn Asn Thr  Ile Pro Gly Pro Gly  Asp Asp Val 
    2750                 2755                 2760             


Leu Ile  Leu Pro Asn Arg Thr  Val Leu Val Asp Thr  Asp Leu Pro 
    2765                 2770                 2775             


Phe Phe  Lys Gly Leu Tyr Val  Met Gly Thr Leu Asp  Phe Pro Val 
    2780                 2785                 2790             


Asp Arg  Ser Asn Val Leu Ser  Val Ala Cys Met Val  Ile Ala Gly 
    2795                 2800                 2805             


Gly Glu  Leu Lys Val Gly Thr  Leu Glu Asn Pro Leu  Glu Lys Glu 
    2810                 2815                 2820             


Gln Lys  Leu Leu Ile Leu Leu  Arg Ala Ser Glu Gly  Val Phe Cys 
    2825                 2830                 2835             


Asp Arg  Met Asn Gly Ile His  Ile Asp Pro Gly Thr  Ile Gly Val 
    2840                 2845                 2850             


Tyr Gly  Lys Val His Leu Tyr  Ser Ala Tyr Pro Lys  Asn Ser Trp 
    2855                 2860                 2865             


Thr His  Leu Gly Ala Asp Ile  Ala Ser Gly Asn Glu  Arg Ile Ile 
    2870                 2875                 2880             


Val Glu  Asp Ala Val Asp Trp  Arg Pro His Asp Lys  Ile Val Leu 
    2885                 2890                 2895             


Ser Ser  Ser Ser Tyr Glu Pro  His Glu Ala Glu Val  Leu Thr Val 
    2900                 2905                 2910             


Lys Glu  Val Lys Gly His His  Val Arg Ile Tyr Glu  Arg Leu Lys 
    2915                 2920                 2925             


His Arg  His Ile Gly Ser Val  His Val Thr Glu Asp  Gly Arg His 
    2930                 2935                 2940             


Ile Arg  Leu Ala Ala Glu Val  Gly Leu Leu Thr Arg  Asn Ile Gln 
    2945                 2950                 2955             


Ile Gln  Pro Asp Val Ser Cys  Arg Gly Arg Leu Phe  Val Gly Ser 
    2960                 2965                 2970             


Phe Arg  Lys Ser Ser Arg Glu  Glu Phe Ser Gly Val  Leu Gln Leu 
    2975                 2980                 2985             


Leu Asn  Val Glu Ile Gln Asn  Phe Gly Ser Pro Leu  Tyr Ser Ser 
    2990                 2995                 3000             


Val Glu  Phe Ser Asn Val Ser  Ala Gly Ser Trp Ile  Ile Ser Ser 
    3005                 3010                 3015             


Thr Leu  His Gln Ser Cys Gly  Gly Gly Ile His Ala  Ala Ala Ser 
    3020                 3025                 3030             


His Gly  Val Leu Leu Asn Asp  Asn Ile Val Phe Gly  Thr Ala Gly 
    3035                 3040                 3045             


His Gly  Ile Asp Leu Glu Gly  Gln Ala Tyr Thr Val  Thr Asn Asn 
    3050                 3055                 3060             


Leu Val  Val Leu Met Thr Gln  Pro Ala Trp Ser Thr  Ile Trp Val 
    3065                 3070                 3075             


Ala Gly  Ile Lys Val Asn Gln  Val Lys Asp Ile Asn  Leu His Gly 
    3080                 3085                 3090             


Asn Val  Val Ala Gly Ser Glu  Arg Leu Gly Phe His  Ile Arg Gly 
    3095                 3100                 3105             


His Lys  Cys Ser Ser Cys Glu  Leu Leu Trp Ser Asp  Asn Val Ala 
    3110                 3115                 3120             


His Ser  Ser Leu His Gly Leu  His Leu Tyr Lys Glu  Ser Gly Leu 
    3125                 3130                 3135             


Asp Asn  Cys Thr Arg Ile Ser  Gly Phe Leu Ala Phe  Lys Asn Phe 
    3140                 3145                 3150             


Asp Tyr  Gly Ala Met Leu His  Val Glu Asn Ser Val  Glu Ile Glu 
    3155                 3160                 3165             


Asn Ile  Thr Leu Val Asp Asn  Thr Ile Gly Leu Leu  Ala Val Val 
    3170                 3175                 3180             


Tyr Val  Phe Ser Ala Pro Gln  Asn Ser Val Lys Lys  Val Gln Ile 
    3185                 3190                 3195             


Val Leu  Arg Asn Ser Val Ile  Val Ala Thr Ser Ser  Ser Phe Asp 
    3200                 3205                 3210             


Cys Ile  Gln Asp Lys Val Lys  Pro His Ser Ala Asn  Leu Thr Ser 
    3215                 3220                 3225             


Thr Asp  Arg Ala Pro Ser Asn  Pro Arg Gly Gly Arg  Ile Gly Ile 
    3230                 3235                 3240             


Leu Trp  Pro Val Phe Thr Ser  Glu Pro Asn Gln Trp  Pro Gln Glu 
    3245                 3250                 3255             


Pro Trp  His Lys Val Arg Asn  Asp His Ser Ile Ser  Gly Ile Met 
    3260                 3265                 3270             


Lys Leu  Gln Asp Val Thr Phe  Ser Ser Phe Val Lys  Ser Cys Tyr 
    3275                 3280                 3285             


Ser Asp  Asp Leu Asp Val Cys  Ile Leu Pro Asn Ala  Glu Asn Ser 
    3290                 3295                 3300             


Gly Ile  Met His Pro Ile Thr  Ala Glu Arg Thr Arg  Met Leu Lys 
    3305                 3310                 3315             


Ile Lys  Asp Lys Asn Lys Phe  Tyr Phe Pro Ser Leu  Gln Pro Arg 
    3320                 3325                 3330             


Lys Asp  Leu Gly Lys Val Val  Cys Pro Glu Leu Asp  Cys Ala Ser 
    3335                 3340                 3345             


Pro Arg  Lys Tyr Leu Phe Lys  Asp Leu Asp Gly Arg  Ala Leu Gly 
    3350                 3355                 3360             


Leu Pro  Pro Pro Val Ser Val  Phe Pro Lys Thr Glu  Ala Glu Trp 
    3365                 3370                 3375             


Thr Ala  Ser Phe Phe Asn Ala  Gly Thr Phe Arg Glu  Glu Gln Lys 
    3380                 3385                 3390             


Cys Thr  Tyr Gln Phe Leu Met  Gln Gly Phe Ile Cys  Lys Gln Thr 
    3395                 3400                 3405             


Asp Gln  Val Val Leu Ile Leu  Asp Ser Ala Asp Ala  Ile Trp Ala 
    3410                 3415                 3420             


Ile Gln  Lys Leu Tyr Pro Val  Val Ser Val Thr Ser  Gly Phe Val 
    3425                 3430                 3435             


Asp Val  Phe Ser Ser Val Asn  Ala Asn Ile Pro Cys  Ser Thr Ser 
    3440                 3445                 3450             


Gly Ser  Val Ser Thr Phe Tyr  Ser Ile Leu Pro Ile  Arg Gln Ile 
    3455                 3460                 3465             


Thr Lys  Val Cys Phe Met Asp  Gln Thr Pro Gln Val  Leu Arg Phe 
    3470                 3475                 3480             


Phe Leu  Leu Gly Asn Lys Ser  Thr Ser Lys Leu Leu  Leu Ala Val 
    3485                 3490                 3495             


Phe Tyr  His Glu Leu Gln Ser  Pro His Val Phe Leu  Gly Glu Ser 
    3500                 3505                 3510             


Phe Ile  Pro Pro Thr Leu Val  Gln Ser Ala Ser Leu  Leu Leu Asn 
    3515                 3520                 3525             


Glu Ser  Ile Gly Ala Asn Tyr  Phe Asn Ile Met Asp  Asn Leu Leu 
    3530                 3535                 3540             


Tyr Val  Val Leu Gln Gly Glu  Glu Pro Ile Glu Ile  Arg Ser Gly 
    3545                 3550                 3555             


Val Ser  Ile His Leu Ala Leu  Thr Val Met Val Ser  Val Leu Glu 
    3560                 3565                 3570             


Lys Gly  Trp Glu Ile Val Ile  Leu Glu Arg Leu Thr  Asn Phe Leu 
    3575                 3580                 3585             


Gln Ile  Gly Gln Asn Gln Ile  Arg Phe Ile His Glu  Met Pro Gly 
    3590                 3595                 3600             


His Glu  Glu Thr Leu Lys Ala  Ile Ala Asp Ser Arg  Ala Lys Arg 
    3605                 3610                 3615             


Lys Arg  Asn Cys Pro Thr Val  Thr Cys Thr Ser His  Tyr Arg Arg 
    3620                 3625                 3630             


Val Gly  Gln Arg Arg Pro Leu  Met Met Glu Met Asn  Ser His Arg 
    3635                 3640                 3645             


Ala Ser  Pro Pro Met Thr Val  Glu Thr Ile Ser Lys  Val Ile Val 
    3650                 3655                 3660             


Ile Glu  Ile Gly Asp Ser Pro  Thr Val Arg Ser Thr  Gly Met Ile 
    3665                 3670                 3675             


Ser Ser  Leu Ser Ser Asn Lys  Leu Gln Asn Leu Ala  His Arg Val 
    3680                 3685                 3690             


Ile Thr  Ala Gln Gln Thr Gly  Val Leu Glu Asn Val  Leu Asn Met 
    3695                 3700                 3705             


Thr Ile  Gly Ala Leu Leu Val  Thr Gln Ser Lys Gly  Val Ile Gly 
    3710                 3715                 3720             


Tyr Gly  Asn Thr Ser Ser Phe  Lys Thr Gly Asn Leu  Ile Tyr Ile 
    3725                 3730                 3735             


Arg Pro  Tyr Ala Leu Ser Ile  Leu Val Gln Pro Ser  Asp Gly Glu 
    3740                 3745                 3750             


Val Gly  Asn Glu Leu Pro Val  Gln Pro Gln Leu Val  Phe Leu Asp 
    3755                 3760                 3765             


Glu Gln  Asn Arg Arg Val Glu  Ser Leu Gly Pro Pro  Ser Glu Pro 
    3770                 3775                 3780             


Trp Thr  Ile Ser Ala Ser Leu  Glu Gly Ala Ser Asp  Ser Val Leu 
    3785                 3790                 3795             


Lys Gly  Cys Thr Gln Ala Glu  Thr Gln Asp Gly Tyr  Val Ser Phe 
    3800                 3805                 3810             


Tyr Asn  Leu Ala Val Leu Ile  Ser Gly Ser Asn Trp  His Phe Ile 
    3815                 3820                 3825             


Phe Thr  Val Thr Ser Pro Pro  Gly Val Asn Phe Thr  Ala Arg Ser 
    3830                 3835                 3840             


Lys Pro  Phe Ala Val Leu Pro  Val Thr Arg Lys Glu  Lys Ser Thr 
    3845                 3850                 3855             


Ile Ile  Leu Ala Ala Ser Leu  Ser Ser Val Ala Ser  Trp Leu Ala 
    3860                 3865                 3870             


Leu Ser  Cys Leu Val Cys Cys  Trp Leu Lys Arg Ser  Lys Ser Arg 
    3875                 3880                 3885             


Lys Thr  Lys Pro Glu Glu Ile  Pro Glu Ser Gln Thr  Asn Asn Gln 
    3890                 3895                 3900             


Asn Ile  His Ile His Ile Ser  Ser Lys Arg Arg Glu  Ser Gln Gly 
    3905                 3910                 3915             


Pro Lys  Lys Glu Asp Thr Val  Val Gly Glu Asp Met  Arg Met Lys 
    3920                 3925                 3930             


Val Met  Leu Gly Lys Val Asn  Gln Cys Pro His Gln  Leu Met Asn 
    3935                 3940                 3945             


Gly Val  Ser Arg Arg Lys Val  Ser Arg His Ile Val  Arg Glu Glu 
    3950                 3955                 3960             


Glu Ala  Ala Val Pro Ala Pro  Gly Thr Thr Gly Ile  Thr Ser His 
    3965                 3970                 3975             


Gly His  Ile Cys Ala Pro Gly  Ala Pro Ala Gln Gln  Val Tyr Leu 
    3980                 3985                 3990             


Gln Glu  Thr Gly Asn Trp Lys  Glu Gly Gln Glu Gln  Leu Leu Arg 
    3995                 4000                 4005             


Tyr Gln  Leu Ala Gly Gln Asn  Gln Leu Leu Leu Leu  Cys Pro Asp 
    4010                 4015                 4020             


Phe Arg  Gln Glu Arg Gln Gln  Leu Pro Gly Gln Ser  Arg Leu Ser 
    4025                 4030                 4035             


Lys Gln  Ser Gly Ser Leu Gly  Leu Ser Gln Glu Lys  Lys Ala Ser 
    4040                 4045                 4050             


Cys Gly  Ala Thr Glu Ala Phe  Cys Leu His Ser Val  His Pro Glu 
    4055                 4060                 4065             


Thr Ile  Gln Glu Gln Leu 
    4070                 


<210>  197
<211>  254
<212>  PRT
<213>  homo sapiens

<400>  197

Met Ala Ser Leu Leu Lys Val Asp Gln Glu Val Lys Leu Lys Val Asp 
1               5                   10                  15      


Ser Phe Arg Glu Arg Ile Thr Ser Glu Ala Glu Asp Leu Val Ala Asn 
            20                  25                  30          


Phe Phe Pro Lys Lys Leu Leu Glu Leu Asp Ser Phe Leu Lys Glu Pro 
        35                  40                  45              


Ile Leu Asn Ile His Asp Leu Thr Gln Ile His Ser Asp Met Asn Leu 
    50                  55                  60                  


Pro Val Pro Asp Pro Ile Leu Leu Thr Asn Ser His Asp Gly Leu Asp 
65                  70                  75                  80  


Gly Pro Thr Tyr Lys Lys Arg Arg Leu Asp Glu Cys Glu Glu Ala Phe 
                85                  90                  95      


Gln Gly Thr Lys Val Phe Val Met Pro Asn Gly Met Leu Lys Ser Asn 
            100                 105                 110         


Gln Gln Leu Val Asp Ile Ile Glu Lys Val Lys Pro Glu Ile Arg Leu 
        115                 120                 125             


Leu Ile Glu Lys Cys Asn Thr Val Lys Met Trp Val Gln Leu Leu Ile 
    130                 135                 140                 


Pro Arg Ile Glu Asp Gly Asn Asn Phe Gly Val Ser Ile Gln Glu Glu 
145                 150                 155                 160 


Thr Val Ala Glu Leu Arg Thr Val Glu Ser Glu Ala Ala Ser Tyr Leu 
                165                 170                 175     


Asp Gln Ile Ser Arg Tyr Tyr Ile Thr Arg Ala Lys Leu Val Ser Lys 
            180                 185                 190         


Ile Ala Lys Tyr Pro His Val Glu Asp Tyr Arg Arg Thr Val Thr Glu 
        195                 200                 205             


Ile Asp Glu Lys Glu Tyr Ile Ser Leu Arg Leu Ile Ile Ser Glu Leu 
    210                 215                 220                 


Arg Asn Gln Tyr Val Thr Leu His Asp Met Ile Leu Lys Asn Ile Glu 
225                 230                 235                 240 


Lys Ile Lys Arg Pro Arg Ser Ser Asn Ala Glu Thr Leu Tyr 
                245                 250                 


<210>  198
<211>  977
<212>  PRT
<213>  homo sapiens

<400>  198

Met Pro Ala Arg Arg Leu Leu Leu Leu Leu Thr Leu Leu Leu Pro Gly 
1               5                   10                  15      


Leu Gly Ile Phe Gly Ser Thr Ser Thr Val Thr Leu Pro Glu Thr Leu 
            20                  25                  30          


Leu Phe Val Ser Thr Leu Asp Gly Ser Leu His Ala Val Ser Lys Arg 
        35                  40                  45              


Thr Gly Ser Ile Lys Trp Thr Leu Lys Glu Asp Pro Val Leu Gln Val 
    50                  55                  60                  


Pro Thr His Val Glu Glu Pro Ala Phe Leu Pro Asp Pro Asn Asp Gly 
65                  70                  75                  80  


Ser Leu Tyr Thr Leu Gly Ser Lys Asn Asn Glu Gly Leu Thr Lys Leu 
                85                  90                  95      


Pro Phe Thr Ile Pro Glu Leu Val Gln Ala Ser Pro Cys Arg Ser Ser 
            100                 105                 110         


Asp Gly Ile Leu Tyr Met Gly Lys Lys Gln Asp Ile Trp Tyr Val Ile 
        115                 120                 125             


Asp Leu Leu Thr Gly Glu Lys Gln Gln Thr Leu Ser Ser Ala Phe Ala 
    130                 135                 140                 


Asp Ser Leu Cys Pro Ser Thr Ser Leu Leu Tyr Leu Gly Arg Thr Glu 
145                 150                 155                 160 


Tyr Thr Ile Thr Met Tyr Asp Thr Lys Thr Arg Glu Leu Arg Trp Asn 
                165                 170                 175     


Ala Thr Tyr Phe Asp Tyr Ala Ala Ser Leu Pro Glu Asp Glu Gly Asp 
            180                 185                 190         


Tyr Lys Met Ser His Phe Val Ser Asn Gly Asp Gly Leu Val Val Thr 
        195                 200                 205             


Val Asp Ser Glu Ser Gly Asp Val Leu Trp Ile Gln Asn Tyr Ala Ser 
    210                 215                 220                 


Pro Val Val Ala Phe Tyr Val Trp Gln Arg Glu Gly Leu Arg Lys Val 
225                 230                 235                 240 


Met His Ile Asn Val Ala Val Glu Thr Leu Arg Tyr Leu Thr Phe Met 
                245                 250                 255     


Ser Gly Glu Val Gly Arg Ile Thr Lys Trp Lys Tyr Pro Phe Pro Lys 
            260                 265                 270         


Glu Thr Glu Ala Lys Ser Lys Leu Thr Pro Thr Leu Tyr Val Gly Lys 
        275                 280                 285             


Tyr Ser Thr Ser Leu Tyr Ala Ser Pro Ser Met Val His Glu Gly Val 
    290                 295                 300                 


Ala Val Val Pro Arg Gly Ser Thr Leu Pro Leu Leu Glu Gly Pro Gln 
305                 310                 315                 320 


Thr Asp Gly Val Thr Ile Gly Asp Lys Gly Glu Cys Val Ile Thr Pro 
                325                 330                 335     


Ser Thr Asp Val Lys Phe Asp Pro Gly Leu Lys Ser Lys Asn Lys Leu 
            340                 345                 350         


Asn Tyr Leu Arg Asn Tyr Trp Leu Leu Ile Gly His His Glu Thr Pro 
        355                 360                 365             


Leu Ser Ala Ser Thr Lys Met Leu Glu Arg Phe Pro Asn Asn Leu Pro 
    370                 375                 380                 


Lys His Arg Glu Asn Val Ile Pro Ala Asp Ser Glu Lys Lys Ser Phe 
385                 390                 395                 400 


Glu Glu Val Ile Asn Leu Val Asp Gln Thr Ser Glu Asn Ala Pro Thr 
                405                 410                 415     


Thr Val Ser Arg Asp Val Glu Glu Lys Pro Ala His Ala Pro Ala Arg 
            420                 425                 430         


Pro Glu Ala Pro Val Asp Ser Met Leu Lys Asp Met Ala Thr Ile Ile 
        435                 440                 445             


Leu Ser Thr Phe Leu Leu Ile Gly Trp Val Ala Phe Ile Ile Thr Tyr 
    450                 455                 460                 


Pro Leu Ser Met His Gln Gln Gln Gln Leu Gln His Gln Gln Phe Gln 
465                 470                 475                 480 


Lys Glu Leu Glu Lys Ile Gln Leu Leu Gln Gln Gln Gln Gln Gln Leu 
                485                 490                 495     


Pro Phe His Pro Pro Gly Asp Thr Ala Gln Asp Gly Glu Leu Leu Asp 
            500                 505                 510         


Thr Ser Gly Pro Tyr Ser Glu Ser Ser Gly Thr Ser Ser Pro Ser Thr 
        515                 520                 525             


Ser Pro Arg Ala Ser Asn His Ser Leu Cys Ser Gly Ser Ser Ala Ser 
    530                 535                 540                 


Lys Ala Gly Ser Ser Pro Ser Leu Glu Gln Asp Asp Gly Asp Glu Glu 
545                 550                 555                 560 


Thr Ser Val Val Ile Val Gly Lys Ile Ser Phe Cys Pro Lys Asp Val 
                565                 570                 575     


Leu Gly His Gly Ala Glu Gly Thr Ile Val Tyr Arg Gly Met Phe Asp 
            580                 585                 590         


Asn Arg Asp Val Ala Val Lys Arg Ile Leu Pro Glu Cys Phe Ser Phe 
        595                 600                 605             


Ala Asp Arg Glu Val Gln Leu Leu Arg Glu Ser Asp Glu His Pro Asn 
    610                 615                 620                 


Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp Arg Gln Phe Gln Tyr Ile 
625                 630                 635                 640 


Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln Glu Tyr Val Glu Gln Lys 
                645                 650                 655     


Asp Phe Ala His Leu Gly Leu Glu Pro Ile Thr Leu Leu Gln Gln Thr 
            660                 665                 670         


Thr Ser Gly Leu Ala His Leu His Ser Leu Asn Ile Val His Arg Asp 
        675                 680                 685             


Leu Lys Pro His Asn Ile Leu Ile Ser Met Pro Asn Ala His Gly Lys 
    690                 695                 700                 


Ile Lys Ala Met Ile Ser Asp Phe Gly Leu Cys Lys Lys Leu Ala Val 
705                 710                 715                 720 


Gly Arg His Ser Phe Ser Arg Arg Ser Gly Val Pro Gly Thr Glu Gly 
                725                 730                 735     


Trp Ile Ala Pro Glu Met Leu Ser Glu Asp Cys Lys Glu Asn Pro Thr 
            740                 745                 750         


Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Val 
        755                 760                 765             


Ser Glu Gly Ser His Pro Phe Gly Lys Ser Leu Gln Arg Gln Ala Asn 
    770                 775                 780                 


Ile Leu Leu Gly Ala Cys Ser Leu Asp Cys Leu His Pro Glu Lys His 
785                 790                 795                 800 


Glu Asp Val Ile Ala Arg Glu Leu Ile Glu Lys Met Ile Ala Met Asp 
                805                 810                 815     


Pro Gln Lys Arg Pro Ser Ala Asn Asp Val Leu Lys His Pro Phe Phe 
            820                 825                 830         


Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Arg 
        835                 840                 845             


Ile Glu Lys Glu Ser Leu Asp Gly Pro Ile Val Lys Gln Leu Glu Arg 
    850                 855                 860                 


Gly Gly Arg Ala Val Val Lys Met Asp Trp Arg Glu Asn Ile Thr Asp 
865                 870                 875                 880 


Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg Thr Tyr Lys Gly Gly Ser 
                885                 890                 895     


Val Arg Asp Leu Leu Arg Ala Met Arg Asn Lys Lys His His Tyr Arg 
            900                 905                 910         


Glu Leu Pro Ala Glu Val Arg Glu Thr Leu Gly Thr Leu Pro Asp Asp 
        915                 920                 925             


Phe Val Cys Tyr Phe Thr Ser Arg Phe Pro His Leu Leu Ala His Thr 
    930                 935                 940                 


Tyr Arg Ala Met Glu Leu Cys Ser His Glu Arg Leu Phe Gln Pro Tyr 
945                 950                 955                 960 


Tyr Phe His Glu Pro Pro Glu Pro Gln Pro Pro Val Thr Pro Asp Ala 
                965                 970                 975     


Leu 
    


<210>  199
<211>  1222
<212>  PRT
<213>  homo sapiens

<400>  199

Met Leu Val Gly Gln Gly Ala Gly Pro Leu Gly Pro Ala Val Val Thr 
1               5                   10                  15      


Ala Ala Val Val Leu Leu Leu Ser Gly Val Gly Pro Ala His Gly Ser 
            20                  25                  30          


Glu Asp Ile Val Val Gly Cys Gly Gly Phe Val Lys Ser Asp Val Glu 
        35                  40                  45              


Ile Asn Tyr Ser Leu Ile Glu Ile Lys Leu Tyr Thr Lys His Gly Thr 
    50                  55                  60                  


Leu Lys Tyr Gln Thr Asp Cys Ala Pro Asn Asn Gly Tyr Phe Met Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Lys Gly Asp Phe Ile Leu Lys Ile Glu Pro Pro Leu 
                85                  90                  95      


Gly Trp Ser Phe Glu Pro Thr Thr Val Glu Leu His Val Asp Gly Val 
            100                 105                 110         


Ser Asp Ile Cys Thr Lys Gly Gly Asp Ile Asn Phe Val Phe Thr Gly 
        115                 120                 125             


Phe Ser Val Asn Gly Lys Val Leu Ser Lys Gly Gln Pro Leu Gly Pro 
    130                 135                 140                 


Ala Gly Val Gln Val Ser Leu Arg Asn Thr Gly Thr Glu Ala Lys Ile 
145                 150                 155                 160 


Gln Ser Thr Val Thr Gln Pro Gly Gly Lys Phe Ala Phe Phe Lys Val 
                165                 170                 175     


Leu Pro Gly Asp Tyr Glu Ile Leu Ala Thr His Pro Thr Trp Ala Leu 
            180                 185                 190         


Lys Glu Ala Ser Thr Thr Val Arg Val Thr Asn Ser Asn Ala Asn Ala 
        195                 200                 205             


Ala Ser Pro Leu Ile Val Ala Gly Tyr Asn Val Ser Gly Ser Val Arg 
    210                 215                 220                 


Ser Asp Gly Glu Pro Met Lys Gly Val Lys Phe Leu Leu Phe Ser Ser 
225                 230                 235                 240 


Leu Val Thr Lys Glu Asp Val Leu Gly Cys Asn Val Ser Pro Val Pro 
                245                 250                 255     


Gly Phe Gln Pro Gln Asp Glu Ser Leu Val Tyr Leu Cys Tyr Thr Val 
            260                 265                 270         


Ser Arg Glu Asp Gly Ser Phe Ser Phe Tyr Ser Leu Pro Ser Gly Gly 
        275                 280                 285             


Tyr Thr Val Ile Pro Phe Tyr Arg Gly Glu Arg Ile Thr Phe Asp Val 
    290                 295                 300                 


Ala Pro Ser Arg Leu Asp Phe Thr Val Glu His Asp Ser Leu Lys Ile 
305                 310                 315                 320 


Glu Pro Val Phe His Val Met Gly Phe Ser Val Thr Gly Arg Val Leu 
                325                 330                 335     


Asn Gly Pro Glu Gly Asp Gly Val Pro Glu Ala Val Val Thr Leu Asn 
            340                 345                 350         


Asn Gln Ile Lys Val Lys Thr Lys Ala Asp Gly Ser Phe Arg Leu Glu 
        355                 360                 365             


Asn Ile Thr Thr Gly Thr Tyr Thr Ile His Ala Gln Lys Glu His Leu 
    370                 375                 380                 


Tyr Phe Glu Thr Val Thr Ile Lys Ile Ala Pro Asn Thr Pro Gln Leu 
385                 390                 395                 400 


Ala Asp Ile Ile Ala Thr Gly Phe Ser Val Cys Gly Gln Ile Ser Ile 
                405                 410                 415     


Ile Arg Phe Pro Asp Thr Val Lys Gln Met Asn Lys Tyr Lys Val Val 
            420                 425                 430         


Leu Ser Ser Gln Asp Lys Asp Lys Ser Leu Val Thr Val Glu Thr Asp 
        435                 440                 445             


Ala His Gly Ser Phe Cys Phe Lys Ala Lys Pro Gly Thr Tyr Lys Val 
    450                 455                 460                 


Gln Val Met Val Pro Glu Ala Glu Thr Arg Ala Gly Leu Thr Leu Lys 
465                 470                 475                 480 


Pro Gln Thr Phe Pro Leu Thr Val Thr Asn Arg Pro Met Met Asp Val 
                485                 490                 495     


Ala Phe Val Gln Phe Leu Ala Ser Val Ser Gly Lys Val Ser Cys Leu 
            500                 505                 510         


Asp Thr Cys Gly Asp Leu Leu Val Thr Leu Gln Ser Leu Ser Arg Gln 
        515                 520                 525             


Gly Glu Lys Arg Ser Leu Gln Leu Ser Gly Lys Val Asn Ala Met Thr 
    530                 535                 540                 


Phe Thr Phe Asp Asn Val Leu Pro Gly Lys Tyr Lys Ile Ser Ile Met 
545                 550                 555                 560 


His Glu Asp Trp Cys Trp Lys Asn Lys Ser Leu Glu Val Glu Val Leu 
                565                 570                 575     


Glu Asp Asp Met Ser Ala Val Glu Phe Arg Gln Thr Gly Tyr Met Leu 
            580                 585                 590         


Arg Cys Ser Leu Ser His Ala Ile Thr Leu Glu Phe Tyr Gln Asp Gly 
        595                 600                 605             


Asn Gly Arg Glu Asn Val Gly Ile Tyr Asn Leu Ser Lys Gly Val Asn 
    610                 615                 620                 


Arg Phe Cys Leu Ser Lys Pro Gly Val Tyr Lys Val Thr Pro Arg Ser 
625                 630                 635                 640 


Cys His Arg Phe Glu Gln Ala Phe Tyr Thr Tyr Asp Thr Ser Ser Pro 
                645                 650                 655     


Ser Ile Leu Thr Leu Thr Ala Ile Arg His His Val Leu Gly Thr Ile 
            660                 665                 670         


Thr Thr Asp Lys Met Met Asp Val Thr Val Thr Ile Lys Ser Ser Ile 
        675                 680                 685             


Asp Ser Glu Pro Ala Leu Val Leu Gly Pro Leu Lys Ser Val Gln Glu 
    690                 695                 700                 


Leu Arg Arg Glu Gln Gln Leu Ala Glu Ile Glu Ala Arg Arg Gln Glu 
705                 710                 715                 720 


Arg Glu Lys Asn Gly Asn Glu Glu Gly Glu Glu Arg Met Thr Lys Pro 
                725                 730                 735     


Pro Val Gln Glu Met Val Asp Glu Leu Gln Gly Pro Phe Ser Tyr Asp 
            740                 745                 750         


Phe Ser Tyr Trp Ala Arg Ser Gly Glu Lys Ile Thr Val Thr Pro Ser 
        755                 760                 765             


Ser Lys Glu Leu Leu Phe Tyr Pro Pro Ser Met Glu Ala Val Val Ser 
    770                 775                 780                 


Gly Glu Ser Cys Pro Gly Lys Leu Ile Glu Ile His Gly Lys Ala Gly 
785                 790                 795                 800 


Leu Phe Leu Glu Gly Gln Ile His Pro Glu Leu Glu Gly Val Glu Ile 
                805                 810                 815     


Val Ile Ser Glu Lys Gly Ala Ser Ser Pro Leu Ile Thr Val Phe Thr 
            820                 825                 830         


Asp Asp Lys Gly Ala Tyr Ser Val Gly Pro Leu His Ser Asp Leu Glu 
        835                 840                 845             


Tyr Thr Val Thr Ser Gln Lys Glu Gly Tyr Val Leu Thr Ala Val Glu 
    850                 855                 860                 


Gly Thr Ile Gly Asp Phe Lys Ala Tyr Ala Leu Ala Gly Val Ser Phe 
865                 870                 875                 880 


Glu Ile Lys Ala Glu Asp Asp Gln Pro Leu Pro Gly Val Leu Leu Ser 
                885                 890                 895     


Leu Ser Gly Gly Leu Phe Arg Ser Asn Leu Leu Thr Gln Asp Asn Gly 
            900                 905                 910         


Ile Leu Thr Phe Ser Asn Leu Ser Pro Gly Gln Tyr Tyr Phe Lys Pro 
        915                 920                 925             


Met Met Lys Glu Phe Arg Phe Glu Pro Ser Ser Gln Met Ile Glu Val 
    930                 935                 940                 


Gln Glu Gly Gln Asn Leu Lys Ile Thr Ile Thr Gly Tyr Arg Thr Ala 
945                 950                 955                 960 


Tyr Ser Cys Tyr Gly Thr Val Ser Ser Leu Asn Gly Glu Pro Glu Gln 
                965                 970                 975     


Gly Val Ala Met Glu Ala Val Gly Gln Asn Asp Cys Ser Ile Tyr Gly 
            980                 985                 990         


Glu Asp Thr Val Thr Asp Glu Glu  Gly Lys Phe Arg Leu  Arg Gly Leu 
        995                 1000                 1005             


Leu Pro  Gly Cys Val Tyr His  Val Gln Leu Lys Ala  Glu Gly Asn 
    1010                 1015                 1020             


Asp His  Ile Glu Arg Ala Leu  Pro His His Arg Val  Ile Glu Val 
    1025                 1030                 1035             


Gly Asn  Asn Asp Ile Asp Asp  Val Asn Ile Ile Val  Phe Arg Gln 
    1040                 1045                 1050             


Ile Asn  Gln Phe Asp Leu Ser  Gly Asn Val Ile Thr  Ser Ser Glu 
    1055                 1060                 1065             


Tyr Leu  Pro Thr Leu Trp Val  Lys Leu Tyr Lys Ser  Glu Asn Leu 
    1070                 1075                 1080             


Asp Asn  Pro Ile Gln Thr Val  Ser Leu Gly Gln Ser  Leu Phe Phe 
    1085                 1090                 1095             


His Phe  Pro Pro Leu Leu Arg  Asp Gly Glu Asn Tyr  Val Val Leu 
    1100                 1105                 1110             


Leu Asp  Ser Thr Leu Pro Arg  Ser Gln Tyr Asp Tyr  Ile Leu Pro 
    1115                 1120                 1125             


Gln Val  Ser Phe Thr Ala Val  Gly Tyr His Lys His  Ile Thr Leu 
    1130                 1135                 1140             


Ile Phe  Asn Pro Thr Arg Lys  Leu Pro Glu Gln Asp  Ile Ala Gln 
    1145                 1150                 1155             


Gly Ser  Tyr Ile Ala Leu Pro  Leu Thr Leu Leu Val  Leu Leu Ala 
    1160                 1165                 1170             


Gly Tyr  Asn His Asp Lys Leu  Ile Pro Leu Leu Leu  Gln Leu Thr 
    1175                 1180                 1185             


Ser Arg  Leu Gln Gly Val Arg  Val Leu Gly Gln Ala  Ala Ser Asp 
    1190                 1195                 1200             


Asn Ser  Gly Pro Glu Asp Ala  Lys Arg Gln Ala Lys  Lys Gln Lys 
    1205                 1210                 1215             


Thr Arg  Arg Thr 
    1220         


<210>  200
<211>  767
<212>  PRT
<213>  homo sapiens

<400>  200

Met Ala Thr Tyr Leu Glu Phe Ile Gln Gln Asn Glu Glu Arg Asp Gly 
1               5                   10                  15      


Val Arg Phe Ser Trp Asn Val Trp Pro Ser Ser Arg Leu Glu Ala Thr 
            20                  25                  30          


Arg Met Val Val Pro Leu Ala Cys Leu Leu Thr Pro Leu Lys Glu Arg 
        35                  40                  45              


Pro Asp Leu Pro Pro Val Gln Tyr Glu Pro Val Leu Cys Ser Arg Pro 
    50                  55                  60                  


Thr Cys Lys Ala Val Leu Asn Pro Leu Cys Gln Val Asp Tyr Arg Ala 
65                  70                  75                  80  


Lys Leu Trp Ala Cys Asn Phe Cys Phe Gln Arg Asn Gln Phe Pro Pro 
                85                  90                  95      


Ala Tyr Gly Gly Ile Ser Glu Val Asn Gln Pro Ala Glu Leu Met Pro 
            100                 105                 110         


Gln Phe Ser Thr Ile Glu Tyr Val Ile Gln Arg Gly Ala Gln Ser Pro 
        115                 120                 125             


Leu Ile Phe Leu Tyr Val Val Asp Thr Cys Leu Glu Glu Asp Asp Leu 
    130                 135                 140                 


Gln Ala Leu Lys Glu Ser Leu Gln Met Ser Leu Ser Leu Leu Pro Pro 
145                 150                 155                 160 


Asp Ala Leu Val Gly Leu Ile Thr Phe Gly Arg Met Val Gln Val His 
                165                 170                 175     


Glu Leu Ser Cys Glu Gly Ile Ser Lys Ser Tyr Val Phe Arg Gly Thr 
            180                 185                 190         


Lys Asp Leu Thr Ala Lys Gln Ile Gln Asp Met Leu Gly Leu Thr Lys 
        195                 200                 205             


Pro Ala Met Pro Met Gln Gln Ala Arg Pro Ala Gln Pro Gln Glu His 
    210                 215                 220                 


Pro Phe Ala Ser Ser Arg Phe Leu Gln Pro Val His Lys Ile Asp Met 
225                 230                 235                 240 


Asn Leu Thr Asp Leu Leu Gly Glu Leu Gln Arg Asp Pro Trp Pro Val 
                245                 250                 255     


Thr Gln Gly Lys Arg Pro Leu Arg Ser Thr Gly Val Ala Leu Ser Ile 
            260                 265                 270         


Ala Val Gly Leu Leu Glu Gly Thr Phe Pro Asn Thr Gly Ala Arg Ile 
        275                 280                 285             


Met Leu Phe Thr Gly Gly Pro Pro Thr Gln Gly Pro Gly Met Val Val 
    290                 295                 300                 


Gly Asp Glu Leu Lys Ile Pro Ile Arg Ser Trp His Asp Ile Glu Lys 
305                 310                 315                 320 


Asp Asn Ala Arg Phe Met Lys Lys Ala Thr Lys His Tyr Glu Met Leu 
                325                 330                 335     


Ala Asn Arg Thr Ala Ala Asn Gly His Cys Ile Asp Ile Tyr Ala Cys 
            340                 345                 350         


Ala Leu Asp Gln Thr Gly Leu Leu Glu Met Lys Cys Cys Ala Asn Leu 
        355                 360                 365             


Thr Gly Gly Tyr Met Val Met Gly Asp Ser Phe Asn Thr Ser Leu Phe 
    370                 375                 380                 


Lys Gln Thr Phe Gln Arg Ile Phe Thr Lys Asp Phe Asn Gly Asp Phe 
385                 390                 395                 400 


Arg Met Ala Phe Gly Ala Thr Leu Asp Val Lys Thr Ser Arg Glu Leu 
                405                 410                 415     


Lys Ile Ala Gly Ala Ile Gly Pro Cys Val Ser Leu Asn Val Lys Gly 
            420                 425                 430         


Pro Cys Val Ser Glu Asn Glu Leu Gly Val Gly Gly Thr Ser Gln Trp 
        435                 440                 445             


Lys Ile Cys Gly Leu Asp Pro Thr Ser Thr Leu Gly Ile Tyr Phe Glu 
    450                 455                 460                 


Val Val Asn Gln His Asn Thr Pro Ile Pro Gln Gly Gly Arg Gly Ala 
465                 470                 475                 480 


Ile Gln Phe Val Thr His Tyr Gln His Ser Ser Thr Gln Arg Arg Ile 
                485                 490                 495     


Arg Val Thr Thr Ile Ala Arg Asn Trp Ala Asp Val Gln Ser Gln Leu 
            500                 505                 510         


Arg His Ile Glu Ala Ala Phe Asp Gln Glu Ala Ala Ala Val Leu Met 
        515                 520                 525             


Ala Arg Leu Gly Val Phe Arg Ala Glu Ser Glu Glu Gly Pro Asp Val 
    530                 535                 540                 


Leu Arg Trp Leu Asp Arg Gln Leu Ile Arg Leu Cys Gln Lys Phe Gly 
545                 550                 555                 560 


Gln Tyr Asn Lys Glu Asp Pro Thr Ser Phe Arg Leu Ser Asp Ser Phe 
                565                 570                 575     


Ser Leu Tyr Pro Gln Phe Met Phe His Leu Arg Arg Ser Pro Phe Leu 
            580                 585                 590         


Gln Val Phe Asn Asn Ser Pro Asp Glu Ser Ser Tyr Tyr Arg His His 
        595                 600                 605             


Phe Ala Arg Gln Asp Leu Thr Gln Ser Leu Ile Met Ile Gln Pro Ile 
    610                 615                 620                 


Leu Tyr Ser Tyr Ser Phe His Gly Pro Pro Glu Pro Val Leu Leu Asp 
625                 630                 635                 640 


Ser Ser Ser Ile Leu Ala Asp Arg Ile Leu Leu Met Asp Thr Phe Phe 
                645                 650                 655     


Gln Ile Val Ile Tyr Leu Gly Glu Thr Ile Ala Gln Trp Arg Lys Ala 
            660                 665                 670         


Gly Tyr Gln Asp Met Pro Glu Tyr Glu Asn Phe Lys His Leu Leu Gln 
        675                 680                 685             


Ala Pro Leu Asp Asp Ala Gln Glu Ile Leu Gln Ala Arg Phe Pro Met 
    690                 695                 700                 


Pro Arg Tyr Ile Asn Thr Glu His Gly Gly Ser Gln Ala Arg Phe Leu 
705                 710                 715                 720 


Leu Ser Lys Val Asn Pro Ser Gln Thr His Asn Asn Leu Tyr Ala Trp 
                725                 730                 735     


Gly Gln Glu Thr Gly Ala Pro Ile Leu Thr Asp Asp Val Ser Leu Gln 
            740                 745                 750         


Val Phe Met Asp His Leu Lys Lys Leu Ala Val Ser Ser Ala Cys 
        755                 760                 765         


<210>  201
<211>  476
<212>  PRT
<213>  homo sapiens

<400>  201

Met Ala Ile Lys Phe Leu Glu Val Ile Lys Pro Phe Cys Val Ile Leu 
1               5                   10                  15      


Pro Glu Ile Gln Lys Pro Glu Arg Lys Ile Gln Phe Lys Glu Lys Val 
            20                  25                  30          


Leu Trp Thr Ala Ile Thr Leu Phe Ile Phe Leu Val Cys Cys Gln Ile 
        35                  40                  45              


Pro Leu Phe Gly Ile Met Ser Ser Asp Ser Ala Asp Pro Phe Tyr Trp 
    50                  55                  60                  


Met Arg Val Ile Leu Ala Ser Asn Arg Gly Thr Leu Met Glu Leu Gly 
65                  70                  75                  80  


Ile Ser Pro Ile Val Thr Ser Gly Leu Ile Met Gln Leu Leu Ala Gly 
                85                  90                  95      


Ala Lys Ile Ile Glu Val Gly Asp Thr Pro Lys Asp Arg Ala Leu Phe 
            100                 105                 110         


Asn Gly Ala Gln Lys Leu Phe Gly Met Ile Ile Thr Ile Gly Gln Ser 
        115                 120                 125             


Ile Val Tyr Val Met Thr Gly Met Tyr Gly Asp Pro Ser Glu Met Gly 
    130                 135                 140                 


Ala Gly Ile Cys Leu Leu Ile Thr Ile Gln Leu Phe Val Ala Gly Leu 
145                 150                 155                 160 


Ile Val Leu Leu Leu Asp Glu Leu Leu Gln Lys Gly Tyr Gly Leu Gly 
                165                 170                 175     


Ser Gly Ile Ser Leu Phe Ile Ala Thr Asn Ile Cys Glu Thr Ile Val 
            180                 185                 190         


Trp Lys Ala Phe Ser Pro Thr Thr Val Asn Thr Gly Arg Gly Met Glu 
        195                 200                 205             


Phe Glu Gly Ala Ile Ile Ala Leu Phe His Leu Leu Ala Thr Arg Thr 
    210                 215                 220                 


Asp Lys Val Arg Ala Leu Arg Glu Ala Phe Tyr Arg Gln Asn Leu Pro 
225                 230                 235                 240 


Asn Leu Met Asn Leu Ile Ala Thr Ile Phe Val Phe Ala Val Val Ile 
                245                 250                 255     


Tyr Phe Gln Gly Phe Arg Val Asp Leu Pro Ile Lys Ser Ala Arg Tyr 
            260                 265                 270         


Arg Gly Gln Tyr Asn Thr Tyr Pro Ile Lys Leu Phe Tyr Thr Ser Asn 
        275                 280                 285             


Ile Pro Ile Ile Leu Gln Ser Ala Leu Val Ser Asn Leu Tyr Val Ile 
    290                 295                 300                 


Ser Gln Met Leu Ser Ala Arg Phe Ser Gly Asn Leu Leu Val Ser Leu 
305                 310                 315                 320 


Leu Gly Thr Trp Ser Asp Thr Ser Ser Gly Gly Pro Ala Arg Ala Tyr 
                325                 330                 335     


Pro Val Gly Gly Leu Cys Tyr Tyr Leu Ser Pro Pro Glu Ser Phe Gly 
            340                 345                 350         


Ser Val Leu Glu Asp Pro Val His Ala Val Val Tyr Ile Val Phe Met 
        355                 360                 365             


Leu Gly Ser Cys Ala Phe Phe Ser Lys Thr Trp Ile Glu Val Ser Gly 
    370                 375                 380                 


Ser Ser Ala Lys Asp Val Ala Lys Gln Leu Lys Glu Gln Gln Met Val 
385                 390                 395                 400 


Met Arg Gly His Arg Glu Thr Ser Met Val His Glu Leu Asn Arg Tyr 
                405                 410                 415     


Ile Pro Thr Ala Ala Ala Phe Gly Gly Leu Cys Ile Gly Ala Leu Ser 
            420                 425                 430         


Val Leu Ala Asp Phe Leu Gly Ala Ile Gly Ser Gly Thr Gly Ile Leu 
        435                 440                 445             


Leu Ala Val Thr Ile Ile Tyr Gln Tyr Phe Glu Ile Phe Val Lys Glu 
    450                 455                 460                 


Gln Ser Glu Val Gly Ser Met Gly Ala Leu Leu Phe 
465                 470                 475     


<210>  202
<211>  687
<212>  PRT
<213>  homo sapiens

<400>  202

Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr 
1               5                   10                  15      


Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val 
            20                  25                  30          


Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg 
        35                  40                  45              


Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly 
    50                  55                  60                  


Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg 
65                  70                  75                  80  


Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln 
                85                  90                  95      


Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile 
            100                 105                 110         


Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser 
        115                 120                 125             


Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro 
    130                 135                 140                 


Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val 
145                 150                 155                 160 


Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys 
                165                 170                 175     


Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile 
            180                 185                 190         


Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly 
        195                 200                 205             


Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val 
    210                 215                 220                 


Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg 
225                 230                 235                 240 


Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly 
                245                 250                 255     


Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val 
            260                 265                 270         


Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu 
        275                 280                 285             


Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala 
    290                 295                 300                 


His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe 
305                 310                 315                 320 


Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys 
                325                 330                 335     


Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu 
            340                 345                 350         


Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr 
        355                 360                 365             


Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu 
    370                 375                 380                 


Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp 
385                 390                 395                 400 


Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile 
                405                 410                 415     


Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly 
            420                 425                 430         


Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly 
        435                 440                 445             


Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys 
    450                 455                 460                 


Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly 
465                 470                 475                 480 


Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr 
                485                 490                 495     


Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg 
            500                 505                 510         


Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr 
        515                 520                 525             


Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Glu Lys Ser Val Pro Leu 
    530                 535                 540                 


Cys Ile Leu Tyr Glu Lys Tyr Arg Asp Cys Leu Thr Glu Ser Asn Leu 
545                 550                 555                 560 


Ile Lys Val Arg Ala Leu Leu Val Glu Pro Val Ile Asn Ser Tyr Leu 
                565                 570                 575     


Leu Ala Glu Arg Asp Leu Tyr Leu Glu Asn Pro Glu Ile Lys Ile Arg 
            580                 585                 590         


Ile Leu Gly Glu Pro Lys Gln Lys Arg Lys Leu Val Ala Glu Val Ser 
        595                 600                 605             


Leu Gln Asn Pro Leu Pro Val Ala Leu Glu Gly Cys Thr Phe Thr Val 
    610                 615                 620                 


Glu Gly Ala Gly Leu Thr Glu Glu Gln Lys Thr Val Glu Ile Pro Asp 
625                 630                 635                 640 


Pro Val Glu Ala Gly Glu Glu Val Lys Val Arg Met Asp Leu Leu Pro 
                645                 650                 655     


Leu His Met Gly Leu His Lys Leu Val Val Asn Phe Glu Ser Asp Lys 
            660                 665                 670         


Leu Lys Ala Val Lys Gly Phe Arg Asn Val Ile Ile Gly Pro Ala 
        675                 680                 685         


<210>  203
<211>  2347
<212>  PRT
<213>  homo sapiens

<400>  203

Met Lys Asn Ile Tyr Cys Leu Ile Pro Lys Leu Val Asn Phe Ala Thr 
1               5                   10                  15      


Leu Gly Cys Leu Trp Ile Ser Val Val Gln Cys Thr Val Leu Asn Ser 
            20                  25                  30          


Cys Leu Lys Ser Cys Val Thr Asn Leu Gly Gln Gln Leu Asp Leu Gly 
        35                  40                  45              


Thr Pro His Asn Leu Ser Glu Pro Cys Ile Gln Gly Cys His Phe Trp 
    50                  55                  60                  


Asn Ser Val Asp Gln Lys Asn Cys Ala Leu Lys Cys Arg Glu Ser Cys 
65                  70                  75                  80  


Glu Val Gly Cys Ser Ser Ala Glu Gly Ala Tyr Glu Glu Glu Val Leu 
                85                  90                  95      


Glu Asn Ala Asp Leu Pro Thr Ala Pro Phe Ala Ser Ser Ile Gly Ser 
            100                 105                 110         


His Asn Met Thr Leu Arg Trp Lys Ser Ala Asn Phe Ser Gly Val Lys 
        115                 120                 125             


Tyr Ile Ile Gln Trp Lys Tyr Ala Gln Leu Leu Gly Ser Trp Thr Tyr 
    130                 135                 140                 


Thr Lys Thr Val Ser Arg Pro Ser Tyr Val Val Lys Pro Leu His Pro 
145                 150                 155                 160 


Phe Thr Glu Tyr Ile Phe Arg Val Val Trp Ile Phe Thr Ala Gln Leu 
                165                 170                 175     


Gln Leu Tyr Ser Pro Pro Ser Pro Ser Tyr Arg Thr His Pro His Gly 
            180                 185                 190         


Val Pro Glu Thr Ala Pro Leu Ile Arg Asn Ile Glu Ser Ser Ser Pro 
        195                 200                 205             


Asp Thr Val Glu Val Ser Trp Asp Pro Pro Gln Phe Pro Gly Gly Pro 
    210                 215                 220                 


Ile Leu Gly Tyr Asn Leu Arg Leu Ile Ser Lys Asn Gln Lys Leu Asp 
225                 230                 235                 240 


Ala Gly Thr Gln Arg Thr Ser Phe Gln Phe Tyr Ser Thr Leu Pro Asn 
                245                 250                 255     


Thr Ile Tyr Arg Phe Ser Ile Ala Ala Val Asn Glu Val Gly Glu Gly 
            260                 265                 270         


Pro Glu Ala Glu Ser Ser Ile Thr Thr Ser Ser Ser Ala Val Gln Gln 
        275                 280                 285             


Glu Glu Gln Trp Leu Phe Leu Ser Arg Lys Thr Ser Leu Arg Lys Arg 
    290                 295                 300                 


Ser Leu Lys His Leu Val Asp Glu Ala His Cys Leu Arg Leu Asp Ala 
305                 310                 315                 320 


Ile Tyr His Asn Ile Thr Gly Ile Ser Val Asp Val His Gln Gln Ile 
                325                 330                 335     


Val Tyr Phe Ser Glu Gly Thr Leu Ile Trp Ala Lys Lys Ala Ala Asn 
            340                 345                 350         


Met Ser Asp Val Ser Asp Leu Arg Ile Phe Tyr Arg Gly Ser Gly Leu 
        355                 360                 365             


Ile Ser Ser Ile Ser Ile Asp Trp Leu Tyr Gln Arg Met Tyr Phe Ile 
    370                 375                 380                 


Met Asp Glu Leu Val Cys Val Cys Asp Leu Glu Asn Cys Ser Asn Ile 
385                 390                 395                 400 


Glu Glu Ile Thr Pro Pro Ser Ile Ser Ala Pro Gln Lys Ile Val Ala 
                405                 410                 415     


Asp Ser Tyr Asn Gly Tyr Val Phe Tyr Leu Leu Arg Asp Gly Ile Tyr 
            420                 425                 430         


Arg Ala Asp Leu Pro Val Pro Ser Gly Arg Cys Ala Glu Ala Val Arg 
        435                 440                 445             


Ile Val Glu Ser Cys Thr Leu Lys Asp Phe Ala Ile Lys Pro Gln Ala 
    450                 455                 460                 


Lys Arg Ile Ile Tyr Phe Asn Asp Thr Ala Gln Val Phe Met Ser Thr 
465                 470                 475                 480 


Phe Leu Asp Gly Ser Ala Ser His Leu Ile Leu Pro Arg Ile Pro Phe 
                485                 490                 495     


Ala Asp Val Lys Ser Phe Ala Cys Glu Asn Asn Asp Phe Leu Val Thr 
            500                 505                 510         


Asp Gly Lys Val Ile Phe Gln Gln Asp Ala Leu Ser Phe Asn Glu Phe 
        515                 520                 525             


Ile Val Gly Cys Asp Leu Ser His Ile Glu Glu Phe Gly Phe Gly Asn 
    530                 535                 540                 


Leu Val Ile Phe Gly Ser Ser Ser Gln Leu His Pro Leu Pro Gly Arg 
545                 550                 555                 560 


Pro Gln Glu Leu Ser Val Leu Phe Gly Ser His Gln Ala Leu Val Gln 
                565                 570                 575     


Trp Lys Pro Pro Ala Leu Ala Ile Gly Ala Asn Val Ile Leu Ile Ser 
            580                 585                 590         


Asp Ile Ile Glu Leu Phe Glu Leu Gly Pro Ser Ala Trp Gln Asn Trp 
        595                 600                 605             


Thr Tyr Glu Val Lys Val Ser Thr Gln Asp Pro Pro Glu Val Thr His 
    610                 615                 620                 


Ile Phe Leu Asn Ile Ser Gly Thr Met Leu Asn Val Pro Glu Leu Gln 
625                 630                 635                 640 


Ser Ala Met Lys Tyr Lys Val Ser Val Arg Ala Ser Ser Pro Lys Arg 
                645                 650                 655     


Pro Gly Pro Trp Ser Glu Pro Ser Val Gly Thr Thr Leu Val Pro Ala 
            660                 665                 670         


Ser Glu Pro Pro Phe Ile Met Ala Val Lys Glu Asp Gly Leu Trp Ser 
        675                 680                 685             


Lys Pro Leu Asn Ser Phe Gly Pro Gly Glu Phe Leu Ser Ser Asp Ile 
    690                 695                 700                 


Gly Asn Val Ser Asp Met Asp Trp Tyr Asn Asn Ser Leu Tyr Tyr Ser 
705                 710                 715                 720 


Asp Thr Lys Gly Asp Val Phe Val Trp Leu Leu Asn Gly Thr Asp Ile 
                725                 730                 735     


Ser Glu Asn Tyr His Leu Pro Ser Ile Ala Gly Ala Gly Ala Leu Ala 
            740                 745                 750         


Phe Glu Trp Leu Gly His Phe Leu Tyr Trp Ala Gly Lys Thr Tyr Val 
        755                 760                 765             


Ile Gln Arg Gln Ser Val Leu Thr Gly His Thr Asp Ile Val Thr His 
    770                 775                 780                 


Val Lys Leu Leu Val Asn Asp Met Val Val Asp Ser Val Gly Gly Tyr 
785                 790                 795                 800 


Leu Tyr Trp Thr Thr Leu Tyr Ser Val Glu Ser Thr Arg Leu Asn Gly 
                805                 810                 815     


Glu Ser Ser Leu Val Leu Gln Thr Gln Pro Trp Phe Ser Gly Lys Lys 
            820                 825                 830         


Val Ile Ala Leu Thr Leu Asp Leu Ser Asp Gly Leu Leu Tyr Trp Leu 
        835                 840                 845             


Val Gln Asp Ser Gln Cys Ile His Leu Tyr Thr Ala Val Leu Arg Gly 
    850                 855                 860                 


Gln Ser Thr Gly Asp Thr Thr Ile Thr Glu Phe Ala Ala Trp Ser Thr 
865                 870                 875                 880 


Ser Glu Ile Ser Gln Asn Ala Leu Met Tyr Tyr Ser Gly Arg Leu Phe 
                885                 890                 895     


Trp Ile Asn Gly Phe Arg Ile Ile Thr Thr Gln Glu Ile Gly Gln Lys 
            900                 905                 910         


Thr Ser Val Ser Val Leu Glu Pro Ala Arg Phe Asn Gln Phe Thr Ile 
        915                 920                 925             


Ile Gln Thr Ser Leu Lys Pro Leu Pro Gly Asn Phe Ser Phe Thr Pro 
    930                 935                 940                 


Lys Val Ile Pro Asp Ser Val Gln Glu Ser Ser Phe Arg Ile Glu Gly 
945                 950                 955                 960 


Asn Ala Ser Ser Phe Gln Ile Leu Trp Asn Gly Pro Pro Ala Val Asp 
                965                 970                 975     


Trp Gly Val Val Phe Tyr Ser Val Glu Phe Ser Ala His Ser Lys Phe 
            980                 985                 990         


Leu Ala Ser Glu Gln His Ser Leu  Pro Val Phe Thr Val  Glu Gly Leu 
        995                 1000                 1005             


Glu Pro  Tyr Ala Leu Phe Asn  Leu Ser Val Thr Pro  Tyr Thr Tyr 
    1010                 1015                 1020             


Trp Gly  Lys Gly Pro Lys Thr  Ser Leu Ser Leu Arg  Ala Pro Glu 
    1025                 1030                 1035             


Thr Val  Pro Ser Ala Pro Glu  Asn Pro Arg Ile Phe  Ile Leu Pro 
    1040                 1045                 1050             


Ser Gly  Lys Cys Cys Asn Lys  Asn Glu Val Val Val  Glu Phe Arg 
    1055                 1060                 1065             


Trp Asn  Lys Pro Lys His Glu  Asn Gly Val Leu Thr  Lys Phe Glu 
    1070                 1075                 1080             


Ile Phe  Tyr Asn Ile Ser Asn  Gln Ser Ile Thr Asn  Lys Thr Cys 
    1085                 1090                 1095             


Glu Asp  Trp Ile Ala Val Asn  Val Thr Pro Ser Val  Met Ser Phe 
    1100                 1105                 1110             


Gln Leu  Glu Gly Met Ser Pro  Arg Cys Phe Ile Ala  Phe Gln Val 
    1115                 1120                 1125             


Arg Ala  Phe Thr Ser Lys Gly  Pro Gly Pro Tyr Ala  Asp Val Val 
    1130                 1135                 1140             


Lys Ser  Thr Thr Ser Glu Ile  Asn Pro Phe Pro His  Leu Ile Thr 
    1145                 1150                 1155             


Leu Leu  Gly Asn Lys Ile Val  Phe Leu Asp Met Asp  Gln Asn Gln 
    1160                 1165                 1170             


Val Val  Trp Thr Phe Ser Ala  Glu Arg Val Ile Ser  Ala Val Cys 
    1175                 1180                 1185             


Tyr Thr  Ala Asp Asn Glu Met  Gly Tyr Tyr Ala Glu  Gly Asp Ser 
    1190                 1195                 1200             


Leu Phe  Leu Leu His Leu His  Asn Arg Ser Ser Ser  Glu Leu Phe 
    1205                 1210                 1215             


Gln Asp  Ser Leu Val Phe Asp  Ile Thr Val Ile Thr  Ile Asp Trp 
    1220                 1225                 1230             


Ile Ser  Arg His Leu Tyr Phe  Ala Leu Lys Glu Ser  Gln Asn Gly 
    1235                 1240                 1245             


Met Gln  Val Phe Asp Val Asp  Leu Glu His Lys Val  Lys Tyr Pro 
    1250                 1255                 1260             


Arg Glu  Val Lys Ile His Asn  Arg Asn Ser Thr Ile  Ile Ser Phe 
    1265                 1270                 1275             


Ser Val  Tyr Pro Leu Leu Ser  Arg Leu Tyr Trp Thr  Glu Val Ser 
    1280                 1285                 1290             


Asn Phe  Gly Tyr Gln Met Phe  Tyr Tyr Ser Ile Ile  Ser His Thr 
    1295                 1300                 1305             


Leu His  Arg Ile Leu Gln Pro  Thr Ala Thr Asn Gln  Gln Asn Lys 
    1310                 1315                 1320             


Arg Asn  Gln Cys Ser Cys Asn  Val Thr Glu Phe Glu  Leu Ser Gly 
    1325                 1330                 1335             


Ala Met  Ala Ile Asp Thr Ser  Asn Leu Glu Lys Pro  Leu Ile Tyr 
    1340                 1345                 1350             


Phe Ala  Lys Ala Gln Glu Ile  Trp Ala Met Asp Leu  Glu Gly Cys 
    1355                 1360                 1365             


Gln Cys  Trp Arg Val Ile Thr  Val Pro Ala Met Leu  Ala Gly Lys 
    1370                 1375                 1380             


Thr Leu  Val Ser Leu Thr Val  Asp Gly Asp Leu Ile  Tyr Trp Ile 
    1385                 1390                 1395             


Ile Thr  Ala Lys Asp Ser Thr  Gln Ile Tyr Gln Ala  Lys Lys Gly 
    1400                 1405                 1410             


Asn Gly  Ala Ile Val Ser Gln  Val Lys Ala Leu Arg  Ser Arg His 
    1415                 1420                 1425             


Ile Leu  Ala Tyr Ser Ser Val  Met Gln Pro Phe Pro  Asp Lys Ala 
    1430                 1435                 1440             


Phe Leu  Ser Leu Ala Ser Asp  Thr Val Glu Pro Thr  Ile Leu Asn 
    1445                 1450                 1455             


Ala Thr  Asn Thr Ser Leu Thr  Ile Arg Leu Pro Leu  Ala Lys Thr 
    1460                 1465                 1470             


Asn Leu  Thr Trp Tyr Gly Ile  Thr Ser Pro Thr Pro  Thr Tyr Leu 
    1475                 1480                 1485             


Val Tyr  Tyr Ala Glu Val Asn  Asp Arg Lys Asn Ser  Ser Asp Leu 
    1490                 1495                 1500             


Lys Tyr  Arg Ile Leu Glu Phe  Gln Asp Ser Ile Ala  Leu Ile Glu 
    1505                 1510                 1515             


Asp Leu  Gln Pro Phe Ser Thr  Tyr Met Ile Gln Ile  Ala Val Lys 
    1520                 1525                 1530             


Asn Tyr  Tyr Ser Asp Pro Leu  Glu His Leu Pro Pro  Gly Lys Glu 
    1535                 1540                 1545             


Ile Trp  Gly Lys Thr Lys Asn  Gly Val Pro Glu Ala  Val Gln Leu 
    1550                 1555                 1560             


Ile Asn  Thr Thr Val Arg Ser  Asp Thr Ser Leu Ile  Ile Ser Trp 
    1565                 1570                 1575             


Arg Glu  Ser His Lys Pro Asn  Gly Pro Lys Glu Ser  Val Arg Tyr 
    1580                 1585                 1590             


Gln Leu  Ala Ile Ser His Leu  Ala Leu Ile Pro Glu  Thr Pro Leu 
    1595                 1600                 1605             


Arg Gln  Ser Glu Phe Pro Asn  Gly Arg Leu Thr Leu  Leu Val Thr 
    1610                 1615                 1620             


Arg Leu  Ser Gly Gly Asn Ile  Tyr Val Leu Lys Val  Leu Ala Cys 
    1625                 1630                 1635             


His Ser  Glu Glu Met Trp Cys  Thr Glu Ser His Pro  Val Thr Val 
    1640                 1645                 1650             


Glu Met  Phe Asn Thr Pro Glu  Lys Pro Tyr Ser Leu  Val Pro Glu 
    1655                 1660                 1665             


Asn Thr  Ser Leu Gln Phe Asn  Trp Lys Ala Pro Leu  Asn Val Asn 
    1670                 1675                 1680             


Leu Ile  Arg Phe Trp Val Glu  Leu Gln Lys Trp Lys  Tyr Asn Glu 
    1685                 1690                 1695             


Phe Tyr  His Val Lys Thr Ser  Cys Ser Gln Gly Pro  Ala Tyr Val 
    1700                 1705                 1710             


Cys Asn  Ile Thr Asn Leu Gln  Pro Tyr Thr Ser Tyr  Asn Val Arg 
    1715                 1720                 1725             


Val Val  Val Val Tyr Lys Thr  Gly Glu Asn Ser Thr  Ser Leu Pro 
    1730                 1735                 1740             


Glu Ser  Phe Lys Thr Lys Ala  Gly Val Pro Asn Lys  Pro Gly Ile 
    1745                 1750                 1755             


Pro Lys  Leu Leu Glu Gly Ser  Lys Asn Ser Ile Gln  Trp Glu Lys 
    1760                 1765                 1770             


Ala Glu  Asp Asn Gly Cys Arg  Ile Thr Tyr Tyr Ile  Leu Glu Ile 
    1775                 1780                 1785             


Arg Lys  Ser Thr Ser Asn Asn  Leu Gln Asn Gln Asn  Leu Arg Trp 
    1790                 1795                 1800             


Lys Met  Thr Phe Asn Gly Ser  Cys Ser Ser Val Cys  Thr Trp Lys 
    1805                 1810                 1815             


Ser Lys  Asn Leu Lys Gly Ile  Phe Gln Phe Arg Val  Val Ala Ala 
    1820                 1825                 1830             


Asn Asn  Leu Gly Phe Gly Glu  Tyr Ser Gly Ile Ser  Glu Asn Ile 
    1835                 1840                 1845             


Ile Leu  Val Gly Asp Asp Phe  Trp Ile Pro Glu Thr  Ser Phe Ile 
    1850                 1855                 1860             


Leu Thr  Ile Ile Val Gly Ile  Phe Leu Val Val Thr  Ile Pro Leu 
    1865                 1870                 1875             


Thr Phe  Val Trp His Arg Arg  Leu Lys Asn Gln Lys  Ser Ala Lys 
    1880                 1885                 1890             


Glu Gly  Val Thr Val Leu Ile  Asn Glu Asp Lys Glu  Leu Ala Glu 
    1895                 1900                 1905             


Leu Arg  Gly Leu Ala Ala Gly  Val Gly Leu Ala Asn  Ala Cys Tyr 
    1910                 1915                 1920             


Ala Ile  His Thr Leu Pro Thr  Gln Glu Glu Ile Glu  Asn Leu Pro 
    1925                 1930                 1935             


Ala Phe  Pro Arg Glu Lys Leu  Thr Leu Arg Leu Leu  Leu Gly Ser 
    1940                 1945                 1950             


Gly Ala  Phe Gly Glu Val Tyr  Glu Gly Thr Ala Val  Asp Ile Leu 
    1955                 1960                 1965             


Gly Val  Gly Ser Gly Glu Ile  Lys Val Ala Val Lys  Thr Leu Lys 
    1970                 1975                 1980             


Lys Gly  Ser Thr Asp Gln Glu  Lys Ile Glu Phe Leu  Lys Glu Ala 
    1985                 1990                 1995             


His Leu  Met Ser Lys Phe Asn  His Pro Asn Ile Leu  Lys Gln Leu 
    2000                 2005                 2010             


Gly Val  Cys Leu Leu Asn Glu  Pro Gln Tyr Ile Ile  Leu Glu Leu 
    2015                 2020                 2025             


Met Glu  Gly Gly Asp Leu Leu  Thr Tyr Leu Arg Lys  Ala Arg Met 
    2030                 2035                 2040             


Ala Thr  Phe Tyr Gly Pro Leu  Leu Thr Leu Val Asp  Leu Val Asp 
    2045                 2050                 2055             


Leu Cys  Val Asp Ile Ser Lys  Gly Cys Val Tyr Leu  Glu Arg Met 
    2060                 2065                 2070             


His Phe  Ile His Arg Asp Leu  Ala Ala Arg Asn Cys  Leu Val Ser 
    2075                 2080                 2085             


Val Lys  Asp Tyr Thr Ser Pro  Arg Ile Val Lys Ile  Gly Asp Phe 
    2090                 2095                 2100             


Gly Leu  Ala Arg Asp Ile Tyr  Lys Asn Asp Tyr Tyr  Arg Lys Arg 
    2105                 2110                 2115             


Gly Glu  Gly Leu Leu Pro Val  Arg Trp Met Ala Pro  Glu Ser Leu 
    2120                 2125                 2130             


Met Asp  Gly Ile Phe Thr Thr  Gln Ser Asp Val Trp  Ser Phe Gly 
    2135                 2140                 2145             


Ile Leu  Ile Trp Glu Ile Leu  Thr Leu Gly His Gln  Pro Tyr Pro 
    2150                 2155                 2160             


Ala His  Ser Asn Leu Asp Val  Leu Asn Tyr Val Gln  Thr Gly Gly 
    2165                 2170                 2175             


Arg Leu  Glu Pro Pro Arg Asn  Cys Pro Asp Asp Leu  Trp Asn Leu 
    2180                 2185                 2190             


Met Thr  Gln Cys Trp Ala Gln  Glu Pro Asp Gln Arg  Pro Thr Phe 
    2195                 2200                 2205             


His Arg  Ile Gln Asp Gln Leu  Gln Leu Phe Arg Asn  Phe Phe Leu 
    2210                 2215                 2220             


Asn Ser  Ile Tyr Lys Ser Arg  Asp Glu Ala Asn Asn  Ser Gly Val 
    2225                 2230                 2235             


Ile Asn  Glu Ser Phe Glu Gly  Glu Asp Gly Asp Val  Ile Cys Leu 
    2240                 2245                 2250             


Asn Ser  Asp Asp Ile Met Pro  Val Ala Leu Met Glu  Thr Lys Asn 
    2255                 2260                 2265             


Arg Glu  Gly Leu Asn Tyr Met  Val Leu Ala Thr Glu  Cys Gly Gln 
    2270                 2275                 2280             


Gly Glu  Glu Lys Ser Glu Gly  Pro Leu Gly Ser Gln  Glu Ser Glu 
    2285                 2290                 2295             


Ser Cys  Gly Leu Arg Lys Glu  Glu Lys Glu Pro His  Ala Asp Lys 
    2300                 2305                 2310             


Asp Phe  Cys Gln Glu Lys Gln  Val Ala Tyr Cys Pro  Ser Gly Lys 
    2315                 2320                 2325             


Pro Glu  Gly Leu Asn Tyr Ala  Cys Leu Thr His Ser  Gly Tyr Gly 
    2330                 2335                 2340             


Asp Gly  Ser Asp 
    2345         


<210>  204
<211>  543
<212>  PRT
<213>  homo sapiens

<400>  204

Met Gly Cys Ile Lys Ser Lys Glu Asn Lys Ser Pro Ala Ile Lys Tyr 
1               5                   10                  15      


Arg Pro Glu Asn Thr Pro Glu Pro Val Ser Thr Ser Val Ser His Tyr 
            20                  25                  30          


Gly Ala Glu Pro Thr Thr Val Ser Pro Cys Pro Ser Ser Ser Ala Lys 
        35                  40                  45              


Gly Thr Ala Val Asn Phe Ser Ser Leu Ser Met Thr Pro Phe Gly Gly 
    50                  55                  60                  


Ser Ser Gly Val Thr Pro Phe Gly Gly Ala Ser Ser Ser Phe Ser Val 
65                  70                  75                  80  


Val Pro Ser Ser Tyr Pro Ala Gly Leu Thr Gly Gly Val Thr Ile Phe 
                85                  90                  95      


Val Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Thr Glu Asp Leu Ser Phe 
            100                 105                 110         


Lys Lys Gly Glu Arg Phe Gln Ile Ile Asn Asn Thr Glu Gly Asp Trp 
        115                 120                 125             


Trp Glu Ala Arg Ser Ile Ala Thr Gly Lys Asn Gly Tyr Ile Pro Ser 
    130                 135                 140                 


Asn Tyr Val Ala Pro Ala Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe 
145                 150                 155                 160 


Gly Lys Met Gly Arg Lys Asp Ala Glu Arg Leu Leu Leu Asn Pro Gly 
                165                 170                 175     


Asn Gln Arg Gly Ile Phe Leu Val Arg Glu Ser Glu Thr Thr Lys Gly 
            180                 185                 190         


Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Glu Ile Arg Gly Asp Asn 
        195                 200                 205             


Val Lys His Tyr Lys Ile Arg Lys Leu Asp Asn Gly Gly Tyr Tyr Ile 
    210                 215                 220                 


Thr Thr Arg Ala Gln Phe Asp Thr Leu Gln Lys Leu Val Lys His Tyr 
225                 230                 235                 240 


Thr Glu His Ala Asp Gly Leu Cys His Lys Leu Thr Thr Val Cys Pro 
                245                 250                 255     


Thr Val Lys Pro Gln Thr Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile 
            260                 265                 270         


Pro Arg Glu Ser Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe 
        275                 280                 285             


Gly Glu Val Trp Met Gly Thr Trp Asn Gly Thr Thr Lys Val Ala Ile 
    290                 295                 300                 


Lys Thr Leu Lys Pro Gly Thr Met Met Pro Glu Ala Phe Leu Gln Glu 
305                 310                 315                 320 


Ala Gln Ile Met Lys Lys Leu Arg His Asp Lys Leu Val Pro Leu Tyr 
                325                 330                 335     


Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Ser 
            340                 345                 350         


Lys Gly Ser Leu Leu Asp Phe Leu Lys Glu Gly Asp Gly Lys Tyr Leu 
        355                 360                 365             


Lys Leu Pro Gln Leu Val Asp Met Ala Ala Gln Ile Ala Asp Gly Met 
    370                 375                 380                 


Ala Tyr Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
385                 390                 395                 400 


Asn Ile Leu Val Gly Glu Asn Leu Val Cys Lys Ile Ala Asp Phe Gly 
                405                 410                 415     


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala 
            420                 425                 430         


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg 
        435                 440                 445             


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Gln Thr Glu 
    450                 455                 460                 


Leu Val Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu 
465                 470                 475                 480 


Val Leu Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Gln Gly 
                485                 490                 495     


Cys Pro Glu Ser Leu His Glu Leu Met Asn Leu Cys Trp Lys Lys Asp 
            500                 505                 510         


Pro Asp Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Phe Leu Glu Asp 
        515                 520                 525             


Tyr Phe Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535                 540             


<210>  205
<211>  1657
<212>  PRT
<213>  homo sapiens

<400>  205

Met Ser Ala Ala Asp Glu Val Asp Gly Leu Gly Val Ala Arg Pro His 
1               5                   10                  15      


Tyr Gly Ser Val Leu Asp Asn Glu Arg Leu Thr Ala Glu Glu Met Asp 
            20                  25                  30          


Glu Arg Arg Arg Gln Asn Val Ala Tyr Glu Tyr Leu Cys His Leu Glu 
        35                  40                  45              


Glu Ala Lys Arg Trp Met Glu Ala Cys Leu Gly Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Thr Glu Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys 
65                  70                  75                  80  


Leu Gly Asn Phe Phe Ser Pro Lys Val Val Ser Leu Lys Lys Ile Tyr 
                85                  90                  95      


Asp Arg Glu Gln Thr Arg Tyr Lys Ala Thr Gly Leu His Phe Arg His 
            100                 105                 110         


Thr Asp Asn Val Ile Gln Trp Leu Asn Ala Met Asp Glu Ile Gly Leu 
        115                 120                 125             


Pro Lys Ile Phe Tyr Pro Glu Thr Thr Asp Ile Tyr Asp Arg Lys Asn 
    130                 135                 140                 


Met Pro Arg Cys Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe 
145                 150                 155                 160 


Lys Leu Gly Leu Ala Pro Gln Ile Gln Asp Leu Tyr Gly Lys Val Asp 
                165                 170                 175     


Phe Thr Glu Glu Glu Ile Asn Asn Met Lys Thr Glu Leu Glu Lys Tyr 
            180                 185                 190         


Gly Ile Gln Met Pro Ala Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn 
        195                 200                 205             


Glu Leu Ser Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile 
    210                 215                 220                 


Asn Glu Ala Ile Asp Arg Arg Ile Pro Ala Asp Thr Phe Ala Ala Leu 
225                 230                 235                 240 


Lys Asn Pro Asn Ala Met Leu Val Asn Leu Glu Glu Pro Leu Ala Ser 
                245                 250                 255     


Thr Tyr Gln Asp Ile Leu Tyr Gln Ala Lys Gln Asp Lys Met Thr Asn 
            260                 265                 270         


Ala Lys Asn Arg Thr Glu Asn Ser Glu Arg Glu Arg Asp Val Tyr Glu 
        275                 280                 285             


Glu Leu Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn 
    290                 295                 300                 


Thr Phe Ser Ala Leu Ala Asn Ile Asp Leu Ala Leu Glu Gln Gly Asp 
305                 310                 315                 320 


Ala Leu Ala Leu Phe Arg Ala Leu Gln Ser Pro Ala Leu Gly Leu Arg 
                325                 330                 335     


Gly Leu Gln Gln Gln Asn Ser Asp Trp Tyr Leu Lys Gln Leu Leu Ser 
            340                 345                 350         


Asp Lys Gln Gln Lys Arg Gln Ser Gly Gln Thr Asp Pro Leu Gln Lys 
        355                 360                 365             


Glu Glu Leu Gln Ser Gly Val Asp Ala Ala Asn Ser Ala Ala Gln Gln 
    370                 375                 380                 


Tyr Gln Arg Arg Leu Ala Ala Val Ala Leu Ile Asn Ala Ala Ile Gln 
385                 390                 395                 400 


Lys Gly Val Ala Glu Lys Thr Val Leu Glu Leu Met Asn Pro Glu Ala 
                405                 410                 415     


Gln Leu Pro Gln Val Tyr Pro Phe Ala Ala Asp Leu Tyr Gln Lys Glu 
            420                 425                 430         


Leu Ala Thr Leu Gln Arg Gln Ser Pro Glu His Asn Leu Thr His Pro 
        435                 440                 445             


Glu Leu Ser Val Ala Val Glu Met Leu Ser Ser Val Ala Leu Ile Asn 
    450                 455                 460                 


Arg Ala Leu Glu Ser Gly Asp Val Asn Thr Val Trp Lys Gln Leu Ser 
465                 470                 475                 480 


Ser Ser Val Thr Gly Leu Thr Asn Ile Glu Glu Glu Asn Cys Gln Arg 
                485                 490                 495     


Tyr Leu Asp Glu Leu Met Lys Leu Lys Ala Gln Ala His Ala Glu Asn 
            500                 505                 510         


Asn Glu Phe Ile Thr Trp Asn Asp Ile Gln Ala Cys Val Asp His Val 
        515                 520                 525             


Asn Leu Val Val Gln Glu Glu His Glu Arg Ile Leu Ala Ile Gly Leu 
    530                 535                 540                 


Ile Asn Glu Ala Leu Asp Glu Gly Asp Ala Gln Lys Thr Leu Gln Ala 
545                 550                 555                 560 


Leu Gln Ile Pro Ala Ala Lys Leu Glu Gly Val Leu Ala Glu Val Ala 
                565                 570                 575     


Gln His Tyr Gln Asp Thr Leu Ile Arg Ala Lys Arg Glu Lys Ala Gln 
            580                 585                 590         


Glu Ile Gln Asp Glu Ser Ala Val Leu Trp Leu Asp Glu Ile Gln Gly 
        595                 600                 605             


Gly Ile Trp Gln Ser Asn Lys Asp Thr Gln Glu Ala Gln Lys Phe Ala 
    610                 615                 620                 


Leu Gly Ile Phe Ala Ile Asn Glu Ala Val Glu Ser Gly Asp Val Gly 
625                 630                 635                 640 


Lys Thr Leu Ser Ala Leu Arg Ser Pro Asp Val Gly Leu Tyr Gly Val 
                645                 650                 655     


Ile Pro Glu Cys Gly Glu Thr Tyr His Ser Asp Leu Ala Glu Ala Lys 
            660                 665                 670         


Lys Lys Lys Leu Ala Val Gly Asp Asn Asn Ser Lys Trp Val Lys His 
        675                 680                 685             


Trp Val Lys Gly Gly Tyr Tyr Tyr Tyr His Asn Leu Glu Thr Gln Glu 
    690                 695                 700                 


Gly Gly Trp Asp Glu Pro Pro Asn Phe Val Gln Asn Ser Met Gln Leu 
705                 710                 715                 720 


Ser Arg Glu Glu Ile Gln Ser Ser Ile Ser Gly Val Thr Ala Ala Tyr 
                725                 730                 735     


Asn Arg Glu Gln Leu Trp Leu Ala Asn Glu Gly Leu Ile Thr Arg Leu 
            740                 745                 750         


Gln Ala Arg Cys Arg Gly Tyr Leu Val Arg Gln Glu Phe Arg Ser Arg 
        755                 760                 765             


Met Asn Phe Leu Lys Lys Gln Ile Pro Ala Ile Thr Cys Ile Gln Ser 
    770                 775                 780                 


Gln Trp Arg Gly Tyr Lys Gln Lys Lys Ala Tyr Gln Asp Arg Leu Ala 
785                 790                 795                 800 


Tyr Leu Arg Ser His Lys Asp Glu Val Val Lys Ile Gln Ser Leu Ala 
                805                 810                 815     


Arg Met His Gln Ala Arg Lys Arg Tyr Arg Asp Arg Leu Gln Tyr Phe 
            820                 825                 830         


Arg Asp His Ile Asn Asp Ile Ile Lys Ile Gln Ala Phe Ile Arg Ala 
        835                 840                 845             


Asn Lys Ala Arg Asp Asp Tyr Lys Thr Leu Ile Asn Ala Glu Asp Pro 
    850                 855                 860                 


Pro Met Val Val Val Arg Lys Phe Val His Leu Leu Asp Gln Ser Asp 
865                 870                 875                 880 


Gln Asp Phe Gln Glu Glu Leu Asp Leu Met Lys Met Arg Glu Glu Val 
                885                 890                 895     


Ile Thr Leu Ile Arg Ser Asn Gln Gln Leu Glu Asn Asp Leu Asn Leu 
            900                 905                 910         


Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Lys Ile Thr Leu Gln 
        915                 920                 925             


Asp Val Val Ser His Ser Lys Lys Leu Thr Lys Lys Asn Lys Glu Gln 
    930                 935                 940                 


Leu Ser Asp Met Met Met Ile Asn Lys Gln Lys Gly Gly Leu Lys Ala 
945                 950                 955                 960 


Leu Ser Lys Glu Lys Arg Glu Lys Leu Glu Ala Tyr Gln His Leu Phe 
                965                 970                 975     


Tyr Leu Leu Gln Thr Asn Pro Thr Tyr Leu Ala Lys Leu Ile Phe Gln 
            980                 985                 990         


Met Pro Gln Asn Lys Ser Thr Lys  Phe Met Asp Ser Val  Ile Phe Thr 
        995                 1000                 1005             


Leu Tyr  Asn Tyr Ala Ser Asn  Gln Arg Glu Glu Tyr  Leu Leu Leu 
    1010                 1015                 1020             


Arg Leu  Phe Lys Thr Ala Leu  Gln Glu Glu Ile Lys  Ser Lys Val 
    1025                 1030                 1035             


Asp Gln  Ile Gln Glu Ile Val  Thr Gly Asn Pro Thr  Val Ile Lys 
    1040                 1045                 1050             


Met Val  Val Ser Phe Asn Arg  Gly Ala Arg Gly Gln  Asn Ala Leu 
    1055                 1060                 1065             


Arg Gln  Ile Leu Ala Pro Val  Val Lys Glu Ile Met  Asp Asp Lys 
    1070                 1075                 1080             


Ser Leu  Asn Ile Lys Thr Asp  Pro Val Asp Ile Tyr  Lys Ser Trp 
    1085                 1090                 1095             


Val Asn  Gln Met Glu Ser Gln  Thr Gly Glu Ala Ser  Lys Leu Pro 
    1100                 1105                 1110             


Tyr Asp  Val Thr Pro Glu Gln  Ala Leu Ala His Glu  Glu Val Lys 
    1115                 1120                 1125             


Thr Arg  Leu Asp Ser Ser Ile  Arg Asn Met Arg Ala  Val Thr Asp 
    1130                 1135                 1140             


Lys Phe  Leu Ser Ala Ile Val  Ser Ser Val Asp Lys  Ile Pro Tyr 
    1145                 1150                 1155             


Gly Met  Arg Phe Ile Ala Lys  Val Leu Lys Asp Ser  Leu His Glu 
    1160                 1165                 1170             


Lys Phe  Pro Asp Ala Gly Glu  Asp Glu Leu Leu Lys  Ile Ile Gly 
    1175                 1180                 1185             


Asn Leu  Leu Tyr Tyr Arg Tyr  Met Asn Pro Ala Ile  Val Ala Pro 
    1190                 1195                 1200             


Asp Ala  Phe Asp Ile Ile Asp  Leu Ser Ala Gly Gly  Gln Leu Thr 
    1205                 1210                 1215             


Thr Asp  Gln Arg Arg Asn Leu  Gly Ser Ile Ala Lys  Met Leu Gln 
    1220                 1225                 1230             


His Ala  Ala Ser Asn Lys Met  Phe Leu Gly Asp Asn  Ala His Leu 
    1235                 1240                 1245             


Ser Ile  Ile Asn Glu Tyr Leu  Ser Gln Ser Tyr Gln  Lys Phe Arg 
    1250                 1255                 1260             


Arg Phe  Phe Gln Thr Ala Cys  Asp Val Pro Glu Leu  Gln Asp Lys 
    1265                 1270                 1275             


Phe Asn  Val Asp Glu Tyr Ser  Asp Leu Val Thr Leu  Thr Lys Pro 
    1280                 1285                 1290             


Val Ile  Tyr Ile Ser Ile Gly  Glu Ile Ile Asn Thr  His Thr Leu 
    1295                 1300                 1305             


Leu Leu  Asp His Gln Asp Ala  Ile Ala Pro Glu His  Asn Asp Pro 
    1310                 1315                 1320             


Ile His  Glu Leu Leu Asp Asp  Leu Gly Glu Val Pro  Thr Ile Glu 
    1325                 1330                 1335             


Ser Leu  Ile Gly Glu Ser Ser  Gly Asn Leu Asn Asp  Pro Asn Lys 
    1340                 1345                 1350             


Glu Ala  Leu Ala Lys Thr Glu  Val Ser Leu Thr Leu  Thr Asn Lys 
    1355                 1360                 1365             


Phe Asp  Val Pro Gly Asp Glu  Asn Ala Glu Met Asp  Ala Arg Thr 
    1370                 1375                 1380             


Ile Leu  Leu Asn Thr Lys Arg  Leu Ile Val Asp Val  Ile Arg Phe 
    1385                 1390                 1395             


Gln Pro  Gly Glu Thr Leu Thr  Glu Ile Leu Glu Thr  Pro Ala Thr 
    1400                 1405                 1410             


Ser Glu  Gln Glu Ala Glu His  Gln Arg Ala Met Gln  Arg Arg Ala 
    1415                 1420                 1425             


Ile Arg  Asp Ala Lys Thr Pro  Asp Lys Met Lys Lys  Ser Lys Ser 
    1430                 1435                 1440             


Val Lys  Glu Asp Ser Asn Leu  Thr Leu Gln Glu Lys  Lys Glu Lys 
    1445                 1450                 1455             


Ile Gln  Thr Gly Leu Lys Lys  Leu Thr Glu Leu Gly  Thr Val Asp 
    1460                 1465                 1470             


Pro Lys  Asn Lys Tyr Gln Glu  Leu Ile Asn Asp Ile  Ala Arg Asp 
    1475                 1480                 1485             


Ile Arg  Asn Gln Arg Arg Tyr  Arg Gln Arg Arg Lys  Ala Glu Leu 
    1490                 1495                 1500             


Val Lys  Leu Gln Gln Thr Tyr  Ala Ala Leu Asn Ser  Lys Ala Thr 
    1505                 1510                 1515             


Phe Tyr  Gly Glu Gln Val Asp  Tyr Tyr Lys Ser Tyr  Ile Lys Thr 
    1520                 1525                 1530             


Cys Leu  Asp Asn Leu Ala Ser  Lys Gly Lys Val Ser  Lys Lys Pro 
    1535                 1540                 1545             


Arg Glu  Met Lys Gly Lys Lys  Ser Lys Lys Ile Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Thr Ala  Ala Arg Leu His Glu  Lys Gly Val Leu Leu  Glu Ile Glu 
    1565                 1570                 1575             


Asp Leu  Gln Val Asn Gln Phe  Lys Asn Val Ile Phe  Glu Ile Ser 
    1580                 1585                 1590             


Pro Thr  Glu Glu Val Gly Asp  Phe Glu Val Lys Ala  Lys Phe Met 
    1595                 1600                 1605             


Gly Val  Gln Met Glu Thr Phe  Met Leu His Tyr Gln  Asp Leu Leu 
    1610                 1615                 1620             


Gln Leu  Gln Tyr Glu Gly Val  Ala Val Met Lys Leu  Phe Asp Arg 
    1625                 1630                 1635             


Ala Lys  Val Asn Val Asn Leu  Leu Ile Phe Leu Leu  Asn Lys Lys 
    1640                 1645                 1650             


Phe Tyr  Gly Lys 
    1655         


<210>  206
<211>  1575
<212>  PRT
<213>  homo sapiens

<400>  206

Met Pro His Glu Glu Leu Pro Ser Leu Gln Arg Pro Arg Tyr Gly Ser 
1               5                   10                  15      


Ile Val Asp Asp Glu Arg Leu Ser Ala Glu Glu Met Asp Glu Arg Arg 
            20                  25                  30          


Arg Gln Asn Ile Ala Tyr Glu Tyr Leu Cys His Leu Glu Glu Ala Lys 
        35                  40                  45              


Arg Trp Met Glu Val Cys Leu Val Glu Glu Leu Pro Pro Thr Thr Glu 
    50                  55                  60                  


Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys Leu Ala Lys 
65                  70                  75                  80  


Phe Phe Ala Pro Lys Met Val Ser Glu Lys Lys Ile Tyr Asp Val Glu 
                85                  90                  95      


Gln Thr Arg Tyr Lys Lys Ser Gly Leu His Phe Arg His Thr Asp Asn 
            100                 105                 110         


Thr Val Gln Trp Leu Arg Ala Met Glu Ser Ile Gly Leu Pro Lys Ile 
        115                 120                 125             


Phe Tyr Pro Glu Thr Thr Asp Val Tyr Asp Arg Lys Asn Ile Pro Arg 
    130                 135                 140                 


Met Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe Lys Leu Gly 
145                 150                 155                 160 


Ile Ala Pro Gln Ile Gln Asp Leu Leu Gly Lys Val Asp Phe Thr Glu 
                165                 170                 175     


Glu Glu Ile Ser Asn Met Arg Lys Glu Leu Glu Lys Tyr Gly Ile Gln 
            180                 185                 190         


Met Pro Ser Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn Glu Leu Ser 
        195                 200                 205             


Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile Asn Glu Ala 
    210                 215                 220                 


Val Glu Lys Gly Ile Ala Glu Gln Thr Val Val Thr Leu Arg Asn Pro 
225                 230                 235                 240 


Asn Ala Val Leu Thr Leu Val Asp Asp Asn Leu Ala Pro Glu Tyr Gln 
                245                 250                 255     


Lys Glu Leu Trp Asp Ala Lys Lys Lys Lys Glu Glu Asn Ala Arg Leu 
            260                 265                 270         


Lys Asn Ser Cys Ile Ser Glu Glu Glu Arg Asp Ala Tyr Glu Glu Leu 
        275                 280                 285             


Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn Arg Gln 
    290                 295                 300                 


Ala Ala Val Asp His Ile Asn Ala Val Ile Pro Glu Gly Asp Pro Glu 
305                 310                 315                 320 


Asn Thr Leu Leu Ala Leu Lys Lys Pro Glu Ala Gln Leu Pro Ala Val 
                325                 330                 335     


Tyr Pro Phe Ala Ala Ala Met Tyr Gln Asn Glu Leu Phe Asn Leu Gln 
            340                 345                 350         


Lys Gln Asn Thr Met Asn Tyr Leu Ala His Glu Glu Leu Leu Ile Ala 
        355                 360                 365             


Val Glu Met Leu Ser Ala Val Ala Leu Leu Asn Gln Ala Leu Glu Ser 
    370                 375                 380                 


Asn Asp Leu Val Ser Val Gln Asn Gln Leu Arg Ser Pro Ala Ile Gly 
385                 390                 395                 400 


Leu Asn Asn Leu Asp Lys Ala Tyr Val Glu Arg Tyr Ala Asn Thr Leu 
                405                 410                 415     


Leu Ser Val Lys Leu Glu Val Leu Ser Gln Gly Gln Asp Asn Leu Ser 
            420                 425                 430         


Trp Asn Glu Ile Gln Asn Cys Ile Asp Met Val Asn Ala Gln Ile Gln 
        435                 440                 445             


Glu Glu Asn Asp Arg Val Val Ala Val Gly Tyr Ile Asn Glu Ala Ile 
    450                 455                 460                 


Asp Glu Gly Asn Pro Leu Arg Thr Leu Glu Thr Leu Leu Leu Pro Thr 
465                 470                 475                 480 


Ala Asn Ile Ser Asp Val Asp Pro Ala His Ala Gln His Tyr Gln Asp 
                485                 490                 495     


Val Leu Tyr His Ala Lys Ser Gln Lys Leu Gly Asp Ser Glu Ser Val 
            500                 505                 510         


Ser Lys Val Leu Trp Leu Asp Glu Ile Gln Gln Ala Val Asp Glu Ala 
        515                 520                 525             


Asn Val Asp Glu Asp Arg Ala Lys Gln Trp Val Thr Leu Val Val Asp 
    530                 535                 540                 


Val Asn Gln Cys Leu Glu Gly Lys Lys Ser Ser Asp Ile Leu Ser Val 
545                 550                 555                 560 


Leu Lys Ser Ser Thr Ser Asn Ala Asn Asp Ile Ile Pro Glu Cys Ala 
                565                 570                 575     


Asp Lys Tyr Tyr Asp Ala Leu Val Lys Ala Lys Glu Leu Lys Ser Glu 
            580                 585                 590         


Arg Val Ser Ser Asp Gly Ser Trp Leu Lys Leu Asn Leu His Lys Lys 
        595                 600                 605             


Tyr Asp Tyr Tyr Tyr Asn Thr Asp Ser Lys Glu Ser Ser Trp Val Thr 
    610                 615                 620                 


Pro Glu Ser Cys Phe Tyr Lys Glu Ser Trp Leu Thr Gly Lys Glu Ile 
625                 630                 635                 640 


Glu Asp Ile Ile Glu Glu Val Thr Val Gly Tyr Ile Arg Glu Asn Ile 
                645                 650                 655     


Trp Ser Ala Ser Glu Glu Leu Leu Leu Arg Phe Gln Ala Thr Ser Ser 
            660                 665                 670         


Gly Pro Ile Leu Arg Glu Glu Phe Glu Ala Arg Lys Ser Phe Leu His 
        675                 680                 685             


Glu Gln Glu Glu Asn Val Val Lys Ile Gln Ala Phe Trp Lys Gly Tyr 
    690                 695                 700                 


Lys Gln Arg Lys Glu Tyr Met His Arg Arg Gln Thr Phe Ile Asp Asn 
705                 710                 715                 720 


Thr Asp Ser Val Val Lys Ile Gln Ser Trp Phe Arg Met Ala Thr Ala 
                725                 730                 735     


Arg Lys Ser Tyr Leu Ser Arg Leu Gln Tyr Phe Arg Asp His Asn Asn 
            740                 745                 750         


Glu Ile Val Lys Ile Gln Ser Leu Leu Arg Ala Asn Lys Ala Arg Asp 
        755                 760                 765             


Asp Tyr Lys Thr Leu Val Gly Ser Glu Asn Pro Pro Leu Thr Val Ile 
    770                 775                 780                 


Arg Lys Phe Val Tyr Leu Leu Asp Gln Ser Asp Leu Asp Phe Gln Glu 
785                 790                 795                 800 


Glu Leu Glu Val Ala Arg Leu Arg Glu Glu Val Val Thr Lys Ile Arg 
                805                 810                 815     


Ala Asn Gln Gln Leu Glu Lys Asp Leu Asn Leu Met Asp Ile Lys Ile 
            820                 825                 830         


Gly Leu Leu Val Lys Asn Arg Ile Thr Leu Glu Asp Val Ile Ser His 
        835                 840                 845             


Ser Lys Lys Leu Asn Lys Lys Lys Gly Gly Glu Met Glu Ile Leu Asn 
    850                 855                 860                 


Asn Thr Asp Asn Gln Gly Ile Lys Ser Leu Ser Lys Glu Arg Arg Lys 
865                 870                 875                 880 


Thr Leu Glu Thr Tyr Gln Gln Leu Phe Tyr Leu Leu Gln Thr Asn Pro 
                885                 890                 895     


Leu Tyr Leu Ala Lys Leu Ile Phe Gln Met Pro Gln Asn Lys Ser Thr 
            900                 905                 910         


Lys Phe Met Asp Thr Val Ile Phe Thr Leu Tyr Asn Tyr Ala Ser Asn 
        915                 920                 925             


Gln Arg Glu Glu Tyr Leu Leu Leu Lys Leu Phe Lys Thr Ala Leu Glu 
    930                 935                 940                 


Glu Glu Ile Lys Ser Lys Val Asp Gln Val Gln Asp Ile Val Thr Gly 
945                 950                 955                 960 


Asn Pro Thr Val Ile Lys Met Val Val Ser Phe Asn Arg Gly Ala Arg 
                965                 970                 975     


Gly Gln Asn Thr Leu Arg Gln Leu Leu Ala Pro Val Val Lys Glu Ile 
            980                 985                 990         


Ile Asp Asp Lys Ser Leu Ile Ile  Asn Thr Asn Pro Val  Glu Val Tyr 
        995                 1000                 1005             


Lys Ala  Trp Val Asn Gln Leu  Glu Thr Gln Thr Gly  Glu Ala Ser 
    1010                 1015                 1020             


Lys Leu  Pro Tyr Asp Val Thr  Thr Glu Gln Ala Leu  Thr Tyr Pro 
    1025                 1030                 1035             


Glu Val  Lys Asn Lys Leu Glu  Ala Ser Ile Glu Asn  Leu Arg Arg 
    1040                 1045                 1050             


Val Thr  Asp Lys Val Leu Asn  Ser Ile Ile Ser Ser  Leu Asp Leu 
    1055                 1060                 1065             


Leu Pro  Tyr Gly Leu Arg Tyr  Ile Ala Lys Val Leu  Lys Asn Ser 
    1070                 1075                 1080             


Ile His  Glu Lys Phe Pro Asp  Ala Thr Glu Asp Glu  Leu Leu Lys 
    1085                 1090                 1095             


Ile Val  Gly Asn Leu Leu Tyr  Tyr Arg Tyr Met Asn  Pro Ala Ile 
    1100                 1105                 1110             


Val Ala  Pro Asp Gly Phe Asp  Ile Ile Asp Met Thr  Ala Gly Gly 
    1115                 1120                 1125             


Gln Ile  Asn Ser Asp Gln Arg  Arg Asn Leu Gly Ser  Val Ala Lys 
    1130                 1135                 1140             


Val Leu  Gln His Ala Ala Ser  Asn Lys Leu Phe Glu  Gly Glu Asn 
    1145                 1150                 1155             


Glu His  Leu Ser Ser Met Asn  Asn Tyr Leu Ser Glu  Thr Tyr Gln 
    1160                 1165                 1170             


Glu Phe  Arg Lys Tyr Phe Lys  Glu Ala Cys Asn Val  Pro Glu Pro 
    1175                 1180                 1185             


Glu Glu  Lys Phe Asn Met Asp  Lys Tyr Thr Asp Leu  Val Thr Val 
    1190                 1195                 1200             


Ser Lys  Pro Val Ile Tyr Ile  Ser Ile Glu Glu Ile  Ile Ser Thr 
    1205                 1210                 1215             


His Ser  Leu Leu Leu Glu His  Gln Asp Ala Ile Ala  Pro Glu Lys 
    1220                 1225                 1230             


Asn Asp  Leu Leu Ser Glu Leu  Leu Gly Ser Leu Gly  Glu Val Pro 
    1235                 1240                 1245             


Thr Val  Glu Ser Phe Leu Gly  Glu Gly Ala Val Asp  Pro Asn Asp 
    1250                 1255                 1260             


Pro Asn  Lys Ala Asn Thr Leu  Ser Gln Leu Ser Lys  Thr Glu Ile 
    1265                 1270                 1275             


Ser Leu  Val Leu Thr Ser Lys  Tyr Asp Ile Glu Asp  Gly Glu Ala 
    1280                 1285                 1290             


Ile Asp  Ser Arg Ser Leu Met  Ile Lys Thr Lys Lys  Leu Ile Ile 
    1295                 1300                 1305             


Asp Val  Ile Arg Asn Gln Pro  Gly Asn Thr Leu Thr  Glu Ile Leu 
    1310                 1315                 1320             


Glu Thr  Pro Ala Thr Ala Gln  Gln Glu Val Asp His  Ala Thr Asp 
    1325                 1330                 1335             


Met Val  Ser Arg Ala Met Ile  Asp Ser Arg Thr Pro  Glu Glu Met 
    1340                 1345                 1350             


Lys His  Ser Gln Ser Met Ile  Glu Asp Ala Gln Leu  Pro Leu Glu 
    1355                 1360                 1365             


Gln Lys  Lys Arg Lys Ile Gln  Arg Asn Leu Arg Thr  Leu Glu Gln 
    1370                 1375                 1380             


Thr Gly  His Val Ser Ser Glu  Asn Lys Tyr Gln Asp  Ile Leu Asn 
    1385                 1390                 1395             


Glu Ile  Ala Lys Asp Ile Arg  Asn Gln Arg Ile Tyr  Arg Lys Leu 
    1400                 1405                 1410             


Arg Lys  Ala Glu Leu Ala Lys  Leu Gln Gln Thr Leu  Asn Ala Leu 
    1415                 1420                 1425             


Asn Lys  Lys Ala Ala Phe Tyr  Glu Glu Gln Ile Asn  Tyr Tyr Asp 
    1430                 1435                 1440             


Thr Tyr  Ile Lys Thr Cys Leu  Asp Asn Leu Lys Arg  Lys Asn Thr 
    1445                 1450                 1455             


Arg Arg  Ser Ile Lys Leu Asp  Gly Lys Gly Glu Pro  Lys Gly Ala 
    1460                 1465                 1470             


Lys Arg  Ala Lys Pro Val Lys  Tyr Thr Ala Ala Lys  Leu His Glu 
    1475                 1480                 1485             


Lys Gly  Val Leu Leu Asp Ile  Asp Asp Leu Gln Thr  Asn Gln Phe 
    1490                 1495                 1500             


Lys Asn  Val Thr Phe Asp Ile  Ile Ala Thr Glu Asp  Val Gly Ile 
    1505                 1510                 1515             


Phe Asp  Val Arg Ser Lys Phe  Leu Gly Val Glu Met  Glu Lys Val 
    1520                 1525                 1530             


Gln Leu  Asn Ile Gln Asp Leu  Leu Gln Met Gln Tyr  Glu Gly Val 
    1535                 1540                 1545             


Ala Val  Met Lys Met Phe Asp  Lys Val Lys Val Asn  Val Asn Leu 
    1550                 1555                 1560             


Leu Ile  Tyr Leu Leu Asn Lys  Lys Phe Tyr Gly Lys  
    1565                 1570                 1575 


<210>  207
<211>  221
<212>  PRT
<213>  homo sapiens

<400>  207

Met Ser Asp Gly Asp Tyr Asp Tyr Leu Ile Lys Phe Leu Ala Leu Gly 
1               5                   10                  15      


Asp Ser Gly Val Gly Lys Thr Ser Val Leu Tyr Gln Tyr Thr Asp Gly 
            20                  25                  30          


Lys Phe Asn Ser Lys Phe Ile Thr Thr Val Gly Ile Asp Phe Arg Glu 
        35                  40                  45              


Lys Arg Val Val Tyr Arg Ala Ser Gly Pro Asp Gly Ala Thr Gly Arg 
    50                  55                  60                  


Gly Gln Arg Ile His Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg 
65                  70                  75                  80  


Phe Arg Ser Leu Thr Thr Ala Phe Phe Arg Asp Ala Met Gly Phe Leu 
                85                  90                  95      


Leu Leu Phe Asp Leu Thr Asn Glu Gln Ser Phe Leu Asn Val Arg Asn 
            100                 105                 110         


Trp Ile Ser Gln Leu Gln Met His Ala Tyr Cys Glu Asn Pro Asp Ile 
        115                 120                 125             


Val Leu Cys Gly Asn Lys Ser Asp Leu Glu Asp Gln Arg Val Val Lys 
    130                 135                 140                 


Glu Glu Glu Ala Ile Ala Leu Ala Glu Lys Tyr Gly Ile Pro Tyr Phe 
145                 150                 155                 160 


Glu Thr Ser Ala Ala Asn Gly Thr Asn Ile Ser Gln Ala Ile Glu Met 
                165                 170                 175     


Leu Leu Asp Leu Ile Met Lys Arg Met Glu Arg Cys Val Asp Lys Ser 
            180                 185                 190         


Trp Ile Pro Glu Gly Val Val Arg Ser Asn Gly His Ala Ser Thr Asp 
        195                 200                 205             


Gln Leu Ser Glu Glu Lys Glu Lys Gly Ala Cys Gly Cys 
    210                 215                 220     


<210>  208
<211>  547
<212>  PRT
<213>  homo sapiens

<400>  208

Met Phe Tyr Tyr Pro Asn Val Leu Gln Arg His Thr Gly Cys Phe Ala 
1               5                   10                  15      


Thr Ile Trp Leu Ala Ala Thr Arg Gly Ser Arg Leu Val Lys Arg Glu 
            20                  25                  30          


Tyr Leu Arg Val Asn Val Val Lys Thr Cys Glu Glu Ile Leu Asn Tyr 
        35                  40                  45              


Val Leu Val Arg Val Gln Pro Pro Gln Pro Gly Leu Pro Arg Pro Arg 
    50                  55                  60                  


Phe Ser Leu Tyr Leu Ser Ala Gln Leu Gln Ile Gly Val Ile Arg Val 
65                  70                  75                  80  


Tyr Ser Gln Gln Cys Gln Tyr Leu Val Glu Asp Ile Gln His Ile Leu 
                85                  90                  95      


Glu Arg Leu His Arg Ala Gln Leu Gln Ile Arg Ile Asp Met Glu Thr 
            100                 105                 110         


Glu Leu Pro Ser Leu Leu Leu Pro Asn His Leu Ala Met Met Glu Thr 
        115                 120                 125             


Leu Glu Asp Ala Pro Asp Pro Phe Phe Gly Met Met Ser Val Asp Pro 
    130                 135                 140                 


Arg Leu Pro Ser Pro Phe Asp Ile Pro Gln Ile Arg His Leu Leu Glu 
145                 150                 155                 160 


Ala Ala Ile Pro Glu Arg Val Glu Glu Ile Pro Pro Glu Val Pro Thr 
                165                 170                 175     


Glu Pro Arg Glu Pro Glu Arg Ile Pro Val Thr Val Leu Pro Pro Glu 
            180                 185                 190         


Ala Ile Thr Ile Leu Glu Ala Glu Pro Ile Arg Met Leu Glu Ile Glu 
        195                 200                 205             


Gly Glu Arg Glu Leu Pro Glu Val Ser Arg Arg Glu Leu Asp Leu Leu 
    210                 215                 220                 


Ile Ala Glu Glu Glu Glu Ala Ile Leu Leu Glu Ile Pro Arg Leu Pro 
225                 230                 235                 240 


Pro Pro Ala Pro Ala Glu Val Glu Gly Ile Gly Glu Ala Leu Gly Pro 
                245                 250                 255     


Glu Glu Leu Arg Leu Thr Gly Trp Glu Pro Gly Ala Leu Leu Met Glu 
            260                 265                 270         


Val Thr Pro Pro Glu Glu Leu Arg Leu Pro Ala Pro Pro Ser Pro Glu 
        275                 280                 285             


Arg Arg Pro Pro Val Pro Pro Pro Pro Arg Arg Arg Arg Arg Arg Arg 
    290                 295                 300                 


Leu Leu Phe Trp Asp Lys Glu Thr Gln Ile Ser Pro Glu Lys Phe Gln 
305                 310                 315                 320 


Glu Gln Leu Gln Thr Arg Ala His Cys Trp Glu Cys Pro Met Val Gln 
                325                 330                 335     


Pro Pro Glu Arg Thr Ile Arg Gly Pro Ala Glu Leu Phe Arg Thr Pro 
            340                 345                 350         


Thr Leu Ser Gly Trp Leu Pro Pro Glu Leu Leu Gly Leu Trp Thr His 
        355                 360                 365             


Cys Ala Gln Pro Pro Pro Lys Ala Leu Arg Arg Glu Leu Pro Glu Glu 
    370                 375                 380                 


Ala Ala Ala Glu Glu Glu Arg Arg Lys Ile Glu Val Pro Ser Glu Ile 
385                 390                 395                 400 


Glu Val Pro Arg Glu Ala Leu Glu Pro Ser Val Pro Leu Met Val Ser 
                405                 410                 415     


Leu Glu Ile Ser Leu Glu Ala Ala Glu Glu Glu Lys Ser Arg Ile Ser 
            420                 425                 430         


Leu Ile Pro Pro Glu Glu Arg Trp Ala Trp Pro Glu Val Glu Ala Pro 
        435                 440                 445             


Glu Ala Pro Ala Leu Pro Val Val Pro Glu Leu Pro Glu Val Pro Met 
    450                 455                 460                 


Glu Met Pro Leu Val Leu Pro Pro Glu Leu Glu Leu Leu Ser Leu Glu 
465                 470                 475                 480 


Ala Val His Arg Ala Val Ala Leu Glu Leu Gln Ala Asn Arg Glu Pro 
                485                 490                 495     


Asp Phe Ser Ser Leu Val Ser Pro Leu Ser Pro Arg Arg Met Ala Ala 
            500                 505                 510         


Arg Val Phe Tyr Leu Leu Leu Val Leu Ser Ala Gln Gln Ile Leu His 
        515                 520                 525             


Val Lys Gln Glu Lys Pro Tyr Gly Arg Leu Leu Ile Gln Pro Gly Pro 
    530                 535                 540                 


Arg Phe His 
545         


<210>  209
<211>  1692
<212>  PRT
<213>  homo sapiens

<400>  209

Met Ser Ser Ala Val Gly Pro Arg Gly Pro Arg Pro Pro Thr Val Pro 
1               5                   10                  15      


Pro Pro Met Gln Glu Leu Pro Asp Leu Ser His Leu Thr Glu Glu Glu 
            20                  25                  30          


Arg Asn Ile Ile Met Ala Val Met Asp Arg Gln Lys Glu Glu Glu Glu 
        35                  40                  45              


Lys Glu Glu Ala Met Leu Lys Cys Val Val Arg Asp Met Ala Lys Pro 
    50                  55                  60                  


Ala Ala Cys Lys Thr Pro Arg Asn Ala Glu Asn Gln Pro His Gln Pro 
65                  70                  75                  80  


Ser Pro Arg Leu His Gln Gln Phe Glu Ser Tyr Lys Glu Gln Val Arg 
                85                  90                  95      


Lys Ile Gly Glu Glu Ala Arg Arg Tyr Gln Gly Glu His Lys Asp Asp 
            100                 105                 110         


Ala Pro Thr Cys Gly Ile Cys His Lys Thr Lys Phe Ala Asp Gly Cys 
        115                 120                 125             


Gly His Leu Cys Ser Tyr Cys Arg Thr Lys Phe Cys Ala Arg Cys Gly 
    130                 135                 140                 


Gly Arg Val Ser Leu Arg Ser Asn Asn Glu Asp Lys Val Val Met Trp 
145                 150                 155                 160 


Val Cys Asn Leu Cys Arg Lys Gln Gln Glu Ile Leu Thr Lys Ser Gly 
                165                 170                 175     


Ala Trp Phe Phe Gly Ser Gly Pro Gln Gln Thr Ser Gln Asp Gly Thr 
            180                 185                 190         


Leu Ser Asp Thr Ala Thr Gly Ala Gly Ser Glu Val Pro Arg Glu Lys 
        195                 200                 205             


Lys Ala Arg Leu Gln Glu Arg Ser Arg Ser Gln Thr Pro Leu Ser Thr 
    210                 215                 220                 


Ala Ala Ala Ser Ser Gln Asp Ala Ala Pro Pro Ser Ala Pro Pro Asp 
225                 230                 235                 240 


Arg Ser Lys Gly Ala Glu Pro Ser Gln Gln Ala Leu Gly Pro Glu Gln 
                245                 250                 255     


Lys Gln Ala Ser Ser Arg Ser Arg Ser Glu Pro Pro Arg Glu Arg Lys 
            260                 265                 270         


Lys Thr Pro Gly Leu Ser Glu Gln Asn Gly Lys Gly Ala Leu Lys Ser 
        275                 280                 285             


Glu Arg Lys Arg Val Pro Lys Thr Ser Ala Gln Pro Val Glu Gly Ala 
    290                 295                 300                 


Val Glu Glu Arg Glu Arg Lys Glu Arg Arg Glu Ser Arg Arg Leu Glu 
305                 310                 315                 320 


Lys Gly Arg Ser Gln Asp Tyr Pro Asp Thr Pro Glu Lys Arg Asp Glu 
                325                 330                 335     


Gly Lys Ala Ala Asp Glu Glu Lys Gln Arg Lys Glu Glu Asp Tyr Gln 
            340                 345                 350         


Thr Arg Tyr Arg Ser Asp Pro Asn Leu Ala Arg Tyr Pro Val Lys Pro 
        355                 360                 365             


Pro Pro Glu Glu Gln Gln Met Arg Met His Ala Arg Val Ser Arg Ala 
    370                 375                 380                 


Arg His Glu Arg Arg His Ser Asp Val Ala Leu Pro Arg Thr Glu Ala 
385                 390                 395                 400 


Gly Ala Ala Leu Pro Glu Gly Lys Ala Gly Lys Arg Ala Pro Ala Ala 
                405                 410                 415     


Ala Arg Ala Ser Pro Pro Asp Ser Pro Arg Ala Tyr Ser Ala Glu Arg 
            420                 425                 430         


Thr Ala Glu Thr Arg Ala Pro Gly Ala Lys Gln Leu Thr Asn His Ser 
        435                 440                 445             


Pro Pro Ala Pro Arg His Gly Pro Val Pro Ala Glu Ala Pro Glu Leu 
    450                 455                 460                 


Lys Ala Gln Glu Pro Leu Arg Lys Gln Ser Arg Leu Asp Pro Ser Ser 
465                 470                 475                 480 


Ala Val Leu Met Arg Lys Ala Lys Arg Glu Lys Val Glu Thr Met Leu 
                485                 490                 495     


Arg Asn Asp Ser Leu Ser Ser Asp Gln Ser Glu Ser Val Arg Pro Ser 
            500                 505                 510         


Pro Pro Lys Pro His Arg Ser Lys Arg Gly Gly Lys Lys Arg Gln Met 
        515                 520                 525             


Ser Val Ser Ser Ser Glu Glu Glu Gly Val Ser Thr Pro Glu Tyr Thr 
    530                 535                 540                 


Ser Cys Glu Asp Val Glu Leu Glu Ser Glu Ser Val Ser Glu Lys Gly 
545                 550                 555                 560 


Asp Leu Asp Tyr Tyr Trp Leu Asp Pro Ala Thr Trp His Ser Arg Glu 
                565                 570                 575     


Thr Ser Pro Ile Ser Ser His Pro Val Thr Trp Gln Pro Ser Lys Glu 
            580                 585                 590         


Gly Asp Arg Leu Ile Gly Arg Val Ile Leu Asn Lys Arg Thr Thr Met 
        595                 600                 605             


Pro Lys Asp Ser Gly Ala Leu Leu Gly Leu Lys Val Val Gly Gly Lys 
    610                 615                 620                 


Met Thr Asp Leu Gly Arg Leu Gly Ala Phe Ile Thr Lys Val Lys Lys 
625                 630                 635                 640 


Gly Ser Leu Ala Asp Val Val Gly His Leu Arg Ala Gly Asp Glu Val 
                645                 650                 655     


Leu Glu Trp Asn Gly Lys Pro Leu Pro Gly Ala Thr Asn Glu Glu Val 
            660                 665                 670         


Tyr Asn Ile Ile Leu Glu Ser Lys Ser Glu Pro Gln Val Glu Ile Ile 
        675                 680                 685             


Val Ser Arg Pro Ile Gly Asp Ile Pro Arg Ile Pro Glu Ser Ser His 
    690                 695                 700                 


Pro Pro Leu Glu Ser Ser Ser Ser Ser Phe Glu Ser Gln Lys Met Glu 
705                 710                 715                 720 


Arg Pro Ser Ile Ser Val Ile Ser Pro Thr Ser Pro Gly Ala Leu Lys 
                725                 730                 735     


Asp Ala Pro Gln Val Leu Pro Gly Gln Leu Ser Val Lys Leu Trp Tyr 
            740                 745                 750         


Asp Lys Val Gly His Gln Leu Ile Val Asn Val Leu Gln Ala Thr Asp 
        755                 760                 765             


Leu Pro Ala Arg Val Asp Gly Arg Pro Arg Asn Pro Tyr Val Lys Met 
    770                 775                 780                 


Tyr Phe Leu Pro Asp Arg Ser Asp Lys Ser Lys Arg Arg Thr Lys Thr 
785                 790                 795                 800 


Val Lys Lys Ile Leu Glu Pro Lys Trp Asn Gln Thr Phe Val Tyr Ser 
                805                 810                 815     


His Val His Arg Arg Asp Phe Arg Glu Arg Met Leu Glu Ile Thr Val 
            820                 825                 830         


Trp Asp Gln Pro Arg Val Gln Glu Glu Glu Ser Glu Phe Leu Gly Glu 
        835                 840                 845             


Ile Leu Ile Glu Leu Glu Thr Ala Leu Leu Asp Asp Glu Pro His Trp 
    850                 855                 860                 


Tyr Lys Leu Gln Thr His Asp Glu Ser Ser Leu Pro Leu Pro Gln Pro 
865                 870                 875                 880 


Ser Pro Phe Met Pro Arg Arg His Ile His Gly Glu Ser Ser Ser Lys 
                885                 890                 895     


Lys Leu Gln Arg Ser Gln Arg Ile Ser Asp Ser Asp Ile Ser Asp Tyr 
            900                 905                 910         


Glu Val Asp Asp Gly Ile Gly Val Val Pro Pro Val Gly Tyr Arg Ser 
        915                 920                 925             


Ser Ala Arg Glu Ser Lys Ser Thr Thr Leu Thr Val Pro Glu Gln Gln 
    930                 935                 940                 


Arg Thr Thr His His Arg Ser Arg Ser Val Ser Pro His Arg Gly Asn 
945                 950                 955                 960 


Asp Gln Gly Lys Pro Arg Ser Arg Leu Pro Asn Val Pro Leu Gln Arg 
                965                 970                 975     


Ser Leu Asp Glu Ile His Pro Thr Arg Arg Ser Arg Ser Pro Thr Arg 
            980                 985                 990         


His His Asp Ala Ser Arg Ser Pro  Val Asp His Arg Thr  Arg Asp Val 
        995                 1000                 1005             


Asp Ser  Gln Tyr Leu Ser Glu  Gln Asp Ser Glu Leu  Leu Met Leu 
    1010                 1015                 1020             


Pro Arg  Ala Lys Arg Gly Arg  Ser Ala Glu Cys Leu  His Thr Thr 
    1025                 1030                 1035             


Arg His  Leu Val Arg His Tyr  Lys Thr Leu Pro Pro  Lys Met Pro 
    1040                 1045                 1050             


Leu Leu  Gln Ser Ser Ser His  Trp Asn Ile Tyr Ser  Ser Ile Leu 
    1055                 1060                 1065             


Pro Ala  His Thr Lys Thr Lys  Ser Val Thr Arg Gln  Asp Ile Ser 
    1070                 1075                 1080             


Leu His  His Glu Cys Phe Asn  Ser Thr Val Leu Arg  Phe Thr Asp 
    1085                 1090                 1095             


Glu Ile  Leu Val Ser Glu Leu  Gln Pro Phe Leu Asp  Arg Ala Arg 
    1100                 1105                 1110             


Ser Ala  Ser Thr Asn Cys Leu  Arg Pro Asp Thr Ser  Leu His Ser 
    1115                 1120                 1125             


Pro Glu  Arg Glu Arg Gly Arg  Trp Ser Pro Ser Leu  Asp Arg Arg 
    1130                 1135                 1140             


Arg Pro  Pro Ser Pro Arg Ile  Gln Ile Gln His Ala  Ser Pro Glu 
    1145                 1150                 1155             


Asn Asp  Arg His Ser Arg Lys  Ser Glu Arg Ser Ser  Ile Gln Lys 
    1160                 1165                 1170             


Gln Thr  Arg Lys Gly Thr Ala  Ser Asp Ala Glu Arg  Val Leu Pro 
    1175                 1180                 1185             


Thr Cys  Leu Ser Arg Arg Gly  His Ala Ala Pro Arg  Ala Thr Asp 
    1190                 1195                 1200             


Gln Pro  Val Ile Arg Gly Lys  His Pro Ala Arg Ser  Arg Ser Ser 
    1205                 1210                 1215             


Glu His  Ser Ser Ile Arg Thr  Leu Cys Ser Met His  His Leu Val 
    1220                 1225                 1230             


Pro Gly  Gly Ser Ala Pro Pro  Ser Pro Leu Leu Thr  Arg Met His 
    1235                 1240                 1245             


Arg Gln  Arg Ser Pro Thr Gln  Ser Pro Pro Ala Asp  Thr Ser Phe 
    1250                 1255                 1260             


Ser Ser  Arg Arg Gly Arg Gln  Leu Pro Gln Val Pro  Val Arg Ser 
    1265                 1270                 1275             


Gly Ser  Ile Glu Gln Ala Ser  Leu Val Val Glu Glu  Arg Thr Arg 
    1280                 1285                 1290             


Gln Met  Lys Met Lys Val His  Arg Phe Lys Gln Thr  Thr Gly Ser 
    1295                 1300                 1305             


Gly Ser  Ser Gln Glu Leu Asp  Arg Glu Gln Tyr Ser  Lys Tyr Asn 
    1310                 1315                 1320             


Ile His  Lys Asp Gln Tyr Arg  Ser Cys Asp Asn Val  Ser Ala Lys 
    1325                 1330                 1335             


Ser Ser  Asp Ser Asp Val Ser  Asp Val Ser Ala Ile  Ser Arg Thr 
    1340                 1345                 1350             


Ser Ser  Ala Ser Arg Leu Ser  Ser Thr Ser Phe Met  Ser Glu Gln 
    1355                 1360                 1365             


Ser Glu  Arg Pro Arg Gly Arg  Ile Ser Ser Phe Thr  Pro Lys Met 
    1370                 1375                 1380             


Gln Gly  Arg Arg Met Gly Thr  Ser Gly Arg Ser Ile  Met Lys Ser 
    1385                 1390                 1395             


Thr Ser  Val Ser Gly Glu Met  Tyr Thr Leu Glu His  Asn Asp Gly 
    1400                 1405                 1410             


Ser Gln  Ser Asp Thr Ala Val  Gly Thr Val Gly Ala  Gly Gly Lys 
    1415                 1420                 1425             


Lys Arg  Arg Ser Ser Leu Ser  Ala Lys Val Val Ala  Ile Val Ser 
    1430                 1435                 1440             


Arg Arg  Ser Arg Ser Thr Ser  Gln Leu Ser Gln Thr  Glu Ser Gly 
    1445                 1450                 1455             


His Lys  Lys Leu Lys Ser Thr  Ile Gln Arg Ser Thr  Glu Thr Gly 
    1460                 1465                 1470             


Met Ala  Ala Glu Met Arg Lys  Met Val Arg Gln Pro  Ser Arg Glu 
    1475                 1480                 1485             


Ser Thr  Asp Gly Ser Ile Asn  Ser Tyr Ser Ser Glu  Gly Asn Leu 
    1490                 1495                 1500             


Ile Phe  Pro Gly Val Arg Leu  Gly Ala Asp Ser Gln  Phe Ser Asp 
    1505                 1510                 1515             


Phe Leu  Asp Gly Leu Gly Pro  Ala Gln Leu Val Gly  Arg Gln Thr 
    1520                 1525                 1530             


Leu Ala  Thr Pro Ala Met Gly  Asp Ile Gln Ile Gly  Met Glu Asp 
    1535                 1540                 1545             


Lys Lys  Gly Gln Leu Glu Val  Glu Val Ile Arg Ala  Arg Ser Leu 
    1550                 1555                 1560             


Thr Gln  Lys Pro Gly Ser Lys  Ser Thr Pro Ala Pro  Tyr Val Lys 
    1565                 1570                 1575             


Val Tyr  Leu Leu Glu Asn Gly  Ala Cys Ile Ala Lys  Lys Lys Thr 
    1580                 1585                 1590             


Arg Ile  Ala Arg Lys Thr Leu  Asp Pro Leu Tyr Gln  Gln Ser Leu 
    1595                 1600                 1605             


Val Phe  Asp Glu Ser Pro Gln  Gly Lys Val Leu Gln  Val Ile Val 
    1610                 1615                 1620             


Trp Gly  Asp Tyr Gly Arg Met  Asp His Lys Cys Phe  Met Gly Val 
    1625                 1630                 1635             


Ala Gln  Ile Leu Leu Glu Glu  Leu Asp Leu Ser Ser  Met Val Ile 
    1640                 1645                 1650             


Gly Trp  Tyr Lys Leu Phe Pro  Pro Ser Ser Leu Val  Asp Pro Thr 
    1655                 1660                 1665             


Leu Thr  Pro Leu Thr Arg Arg  Ala Ser Gln Ser Ser  Leu Glu Ser 
    1670                 1675                 1680             


Ser Thr  Gly Pro Pro Cys Ile  Arg Ser 
    1685                 1690         


<210>  210
<211>  1805
<212>  PRT
<213>  homo sapiens

<400>  210

Gly Gly Leu Leu Gln Thr Glu Thr Thr Leu Gly Leu Ser Ser Tyr Gln 
1               5                   10                  15      


Gln Lys Ser Ile Ser Leu Tyr Arg Gly Asn Cys Arg Pro Ile Arg Phe 
            20                  25                  30          


Glu Pro Pro Met Leu Asp Phe His Glu Gln Pro Val Gly Met Pro Lys 
        35                  40                  45              


Met Glu Lys Val Tyr Leu His Asn Pro Ser Ser Glu Glu Thr Ile Thr 
    50                  55                  60                  


Leu Val Ser Ile Ser Ala Thr Thr Ser His Phe His Ala Ser Phe Phe 
65                  70                  75                  80  


Gln Asn Arg Lys Ile Leu Pro Gly Gly Asn Thr Ser Phe Asp Val Val 
                85                  90                  95      


Phe Leu Ala Arg Val Val Gly Asn Val Glu Asn Thr Leu Phe Ile Asn 
            100                 105                 110         


Thr Ser Asn His Gly Val Phe Thr Tyr Gln Val Phe Gly Val Gly Val 
        115                 120                 125             


Pro Asn Pro Tyr Arg Leu Arg Pro Phe Leu Gly Ala Arg Val Pro Val 
    130                 135                 140                 


Asn Ser Ser Phe Ser Pro Ile Ile Asn Ile His Asn Pro His Ser Glu 
145                 150                 155                 160 


Pro Leu Gln Val Val Glu Met Tyr Ser Ser Gly Gly Asp Leu His Leu 
                165                 170                 175     


Glu Leu Pro Thr Gly Gln Gln Gly Gly Thr Arg Lys Leu Trp Glu Ile 
            180                 185                 190         


Pro Pro Tyr Glu Thr Lys Gly Val Met Arg Ala Ser Phe Ser Ser Arg 
        195                 200                 205             


Glu Ala Asp Asn His Thr Ala Phe Ile Arg Ile Lys Thr Asn Ala Ser 
    210                 215                 220                 


Asp Ser Thr Glu Phe Ile Ile Leu Pro Val Glu Val Glu Val Thr Thr 
225                 230                 235                 240 


Ala Pro Gly Ile Tyr Ser Ser Thr Glu Met Leu Asp Phe Gly Thr Leu 
                245                 250                 255     


Arg Thr Gln Asp Leu Pro Lys Val Leu Asn Leu His Leu Leu Asn Ser 
            260                 265                 270         


Gly Thr Lys Asp Val Pro Ile Thr Ser Val Arg Pro Thr Pro Gln Asn 
        275                 280                 285             


Asp Ala Ile Thr Val His Phe Lys Pro Ile Thr Leu Lys Ala Ser Glu 
    290                 295                 300                 


Ser Lys Tyr Thr Lys Val Ala Ser Ile Ser Phe Asp Ala Ser Lys Ala 
305                 310                 315                 320 


Lys Lys Pro Ser Gln Phe Ser Gly Lys Ile Thr Val Lys Ala Lys Glu 
                325                 330                 335     


Lys Ser Tyr Ser Lys Leu Glu Ile Pro Tyr Gln Ala Glu Val Leu Asp 
            340                 345                 350         


Gly Tyr Leu Gly Phe Asp His Ala Ala Thr Leu Phe His Ile Arg Asp 
        355                 360                 365             


Ser Pro Ala Asp Pro Val Glu Arg Pro Ile Tyr Leu Thr Asn Thr Phe 
    370                 375                 380                 


Ser Phe Ala Ile Leu Ile His Asp Val Leu Leu Pro Glu Glu Ala Lys 
385                 390                 395                 400 


Thr Met Phe Lys Val His Asn Phe Ser Lys Pro Val Leu Ile Leu Pro 
                405                 410                 415     


Asn Glu Ser Gly Tyr Ile Phe Thr Leu Leu Phe Met Pro Ser Thr Ser 
            420                 425                 430         


Ser Met His Ile Asp Asn Asn Ile Leu Leu Ile Thr Asn Ala Ser Lys 
        435                 440                 445             


Phe His Leu Pro Val Arg Val Tyr Thr Gly Phe Leu Asp Tyr Phe Val 
    450                 455                 460                 


Leu Pro Pro Lys Ile Glu Glu Arg Phe Ile Asp Phe Gly Val Leu Ser 
465                 470                 475                 480 


Ala Thr Glu Ala Ser Asn Ile Leu Phe Ala Ile Ile Asn Ser Asn Pro 
                485                 490                 495     


Ile Glu Leu Ala Ile Lys Ser Trp His Ile Ile Gly Asp Gly Leu Ser 
            500                 505                 510         


Ile Glu Leu Val Ala Val Glu Arg Gly Asn Arg Thr Thr Ile Ile Ser 
        515                 520                 525             


Ser Leu Pro Glu Phe Glu Lys Ser Ser Leu Ser Asp Gln Ser Ser Val 
    530                 535                 540                 


Thr Leu Ala Ser Gly Tyr Phe Ala Val Phe Arg Val Lys Leu Thr Ala 
545                 550                 555                 560 


Lys Lys Leu Glu Gly Ile His Asp Gly Ala Ile Gln Ile Thr Thr Asp 
                565                 570                 575     


Tyr Glu Ile Leu Thr Ile Pro Val Lys Ala Val Ile Ala Val Gly Ser 
            580                 585                 590         


Leu Thr Cys Phe Pro Lys His Val Val Leu Pro Pro Ser Phe Pro Gly 
        595                 600                 605             


Lys Ile Val His Gln Ser Leu Asn Ile Met Asn Ser Phe Ser Gln Lys 
    610                 615                 620                 


Val Lys Ile Gln Gln Ile Arg Ser Leu Ser Glu Asp Val Arg Phe Tyr 
625                 630                 635                 640 


Tyr Lys Arg Leu Arg Gly Asn Lys Glu Asp Leu Glu Pro Gly Lys Lys 
                645                 650                 655     


Ser Lys Ile Ala Asn Ile Tyr Phe Asp Pro Gly Leu Gln Cys Gly Asp 
            660                 665                 670         


His Cys Tyr Val Gly Leu Pro Phe Leu Ser Lys Ser Glu Pro Lys Val 
        675                 680                 685             


Gln Pro Gly Val Ala Met Gln Glu Asp Met Trp Asp Ala Asp Trp Asp 
    690                 695                 700                 


Leu His Gln Ser Leu Phe Lys Gly Trp Thr Gly Ile Lys Glu Asn Ser 
705                 710                 715                 720 


Gly His Arg Leu Ser Ala Ile Phe Glu Val Asn Thr Asp Leu Gln Lys 
                725                 730                 735     


Asn Ile Ile Ser Lys Ile Thr Ala Glu Leu Ser Trp Pro Ser Ile Leu 
            740                 745                 750         


Ser Ser Pro Arg His Leu Lys Phe Pro Leu Thr Asn Thr Asn Cys Ser 
        755                 760                 765             


Ser Glu Glu Glu Ile Thr Leu Glu Asn Pro Ala Asp Val Pro Val Tyr 
    770                 775                 780                 


Val Gln Phe Ile Pro Leu Ala Leu Tyr Ser Asn Pro Ser Val Phe Val 
785                 790                 795                 800 


Asp Lys Leu Val Ser Arg Phe Asn Leu Ser Lys Val Ala Lys Ile Asp 
                805                 810                 815     


Leu Arg Thr Leu Glu Phe Gln Val Phe Arg Asn Ser Ala His Pro Leu 
            820                 825                 830         


Gln Ser Ser Thr Gly Phe Met Glu Gly Leu Ser Arg His Leu Ile Leu 
        835                 840                 845             


Asn Leu Ile Leu Lys Pro Gly Glu Lys Lys Ser Val Lys Val Lys Phe 
    850                 855                 860                 


Thr Pro Val His Asn Arg Thr Val Ser Ser Leu Ile Ile Val Arg Asn 
865                 870                 875                 880 


Asn Leu Thr Val Met Asp Ala Val Met Val Gln Gly Gln Gly Thr Thr 
                885                 890                 895     


Glu Asn Leu Arg Val Ala Gly Lys Leu Pro Gly Pro Gly Ser Ser Leu 
            900                 905                 910         


Arg Phe Lys Ile Thr Glu Ala Leu Leu Lys Asp Cys Thr Asp Ser Leu 
        915                 920                 925             


Lys Leu Arg Glu Pro Asn Phe Thr Leu Lys Arg Thr Phe Lys Val Glu 
    930                 935                 940                 


Asn Thr Gly Gln Leu Gln Ile His Ile Glu Thr Ile Glu Ile Ser Gly 
945                 950                 955                 960 


Tyr Ser Cys Glu Gly Tyr Gly Phe Lys Val Val Asn Cys Gln Glu Phe 
                965                 970                 975     


Thr Leu Ser Ala Asn Ala Ser Arg Asp Ile Ile Ile Leu Phe Thr Pro 
            980                 985                 990         


Asp Phe Thr Ala Ser Arg Val Ile  Arg Glu Leu Lys Phe  Ile Thr Thr 
        995                 1000                 1005             


Ser Gly  Ser Glu Phe Val Phe  Ile Leu Asn Ala Ser  Leu Pro Tyr 
    1010                 1015                 1020             


His Met  Leu Ala Thr Cys Ala  Glu Ala Leu Pro Arg  Pro Asn Trp 
    1025                 1030                 1035             


Glu Leu  Ala Leu Tyr Ile Ile  Ile Ser Gly Ile Met  Ser Ala Leu 
    1040                 1045                 1050             


Phe Leu  Leu Val Ile Gly Thr  Ala Tyr Leu Glu Ala  Gln Gly Ile 
    1055                 1060                 1065             


Trp Glu  Pro Phe Arg Arg Arg  Leu Ser Phe Glu Ala  Ser Asn Pro 
    1070                 1075                 1080             


Pro Phe  Asp Val Gly Arg Pro  Phe Asp Leu Arg Arg  Ile Val Gly 
    1085                 1090                 1095             


Ile Ser  Ser Glu Gly Asn Leu  Asn Thr Leu Ser Cys  Asp Pro Gly 
    1100                 1105                 1110             


His Ser  Arg Gly Phe Cys Gly  Ala Gly Gly Ser Ser  Ser Arg Pro 
    1115                 1120                 1125             


Ser Ala  Gly Ser His Lys Gln  Cys Gly Pro Ser Val  His Pro His 
    1130                 1135                 1140             


Ser Ser  His Ser Asn Arg Asn  Ser Ala Asp Val Glu  Asn Val Arg 
    1145                 1150                 1155             


Ala Lys  Asn Ser Ser Ser Thr  Ser Ser Arg Thr Ser  Ala Gln Ala 
    1160                 1165                 1170             


Ala Ser  Ser Gln Ser Ala Asn  Lys Thr Ser Pro Leu  Val Leu Asp 
    1175                 1180                 1185             


Ser Asn  Thr Val Thr Gln Gly  His Thr Ala Gly Arg  Lys Ser Lys 
    1190                 1195                 1200             


Gly Ala  Lys Gln Ser Gln His  Gly Ser Gln His His  Ala His Ser 
    1205                 1210                 1215             


Pro Leu  Glu Gln His Pro Gln  Pro Pro Leu Pro Pro  Pro Val Pro 
    1220                 1225                 1230             


Gln Pro  Gln Glu Pro Gln Pro  Glu Arg Leu Ser Pro  Ala Pro Leu 
    1235                 1240                 1245             


Ala His  Pro Ser His Pro Glu  Arg Ala Ser Ser Ala  Arg His Ser 
    1250                 1255                 1260             


Ser Glu  Asp Ser Asp Ile Thr  Ser Leu Ile Glu Ala  Met Asp Lys 
    1265                 1270                 1275             


Asp Phe  Asp His His Asp Ser  Pro Ala Leu Glu Val  Phe Thr Glu 
    1280                 1285                 1290             


Gln Pro  Pro Ser Pro Leu Pro  Lys Ser Lys Gly Lys  Gly Lys Pro 
    1295                 1300                 1305             


Leu Gln  Arg Lys Val Lys Pro  Pro Lys Lys Gln Glu  Glu Lys Glu 
    1310                 1315                 1320             


Lys Lys  Gly Lys Gly Lys Pro  Gln Glu Asp Glu Leu  Lys Asp Ser 
    1325                 1330                 1335             


Leu Ala  Asp Asp Asp Ser Ser  Ser Thr Thr Thr Glu  Thr Ser Asn 
    1340                 1345                 1350             


Pro Asp  Thr Glu Pro Leu Leu  Lys Glu Asp Thr Glu  Lys Gln Lys 
    1355                 1360                 1365             


Gly Lys  Gln Ala Met Pro Glu  Lys His Glu Ser Glu  Met Ser Gln 
    1370                 1375                 1380             


Val Lys  Gln Lys Ser Lys Lys  Leu Leu Asn Ile Lys  Lys Glu Ile 
    1385                 1390                 1395             


Pro Thr  Asp Val Lys Pro Ser  Ser Leu Glu Leu Pro  Tyr Thr Pro 
    1400                 1405                 1410             


Pro Leu  Glu Ser Lys Gln Arg  Arg Asn Leu Pro Ser  Lys Ile Pro 
    1415                 1420                 1425             


Leu Pro  Thr Ala Met Thr Ser  Gly Ser Lys Ser Arg  Asn Ala Gln 
    1430                 1435                 1440             


Lys Thr  Lys Gly Thr Ser Lys  Leu Val Asp Asn Arg  Pro Pro Ala 
    1445                 1450                 1455             


Leu Ala  Lys Phe Leu Pro Asn  Ser Gln Glu Leu Gly  Asn Thr Ser 
    1460                 1465                 1470             


Ser Ser  Glu Gly Glu Lys Asp  Ser Pro Pro Pro Glu  Trp Asp Ser 
    1475                 1480                 1485             


Val Pro  Val His Lys Pro Gly  Ser Ser Thr Asp Ser  Leu Tyr Lys 
    1490                 1495                 1500             


Leu Ser  Leu Gln Thr Leu Asn  Ala Asp Ile Phe Leu  Lys Gln Arg 
    1505                 1510                 1515             


Gln Thr  Ser Pro Thr Pro Ala  Ser Pro Ser Pro Pro  Ala Ala Pro 
    1520                 1525                 1530             


Cys Pro  Phe Val Ala Arg Gly  Ser Tyr Ser Ser Ile  Val Asn Ser 
    1535                 1540                 1545             


Ser Ser  Ser Ser Asp Pro Lys  Ile Lys Gln Pro Asn  Gly Ser Lys 
    1550                 1555                 1560             


His Lys  Leu Thr Lys Ala Ala  Ser Leu Pro Gly Lys  Asn Gly Asn 
    1565                 1570                 1575             


Pro Thr  Phe Ala Ala Val Thr  Ala Gly Tyr Asp Lys  Ser Pro Gly 
    1580                 1585                 1590             


Gly Asn  Gly Phe Ala Lys Val  Ser Ser Asn Lys Thr  Gly Phe Ser 
    1595                 1600                 1605             


Ser Ser  Leu Gly Ile Ser His  Ala Pro Val Asp Ser  Asp Gly Ser 
    1610                 1615                 1620             


Asp Ser  Ser Gly Leu Trp Ser  Pro Val Ser Asn Pro  Ser Ser Pro 
    1625                 1630                 1635             


Asp Phe  Thr Pro Leu Asn Ser  Phe Ser Ala Phe Gly  Asn Ser Phe 
    1640                 1645                 1650             


Asn Leu  Thr Gly Glu Val Phe  Ser Lys Leu Gly Leu  Ser Arg Ser 
    1655                 1660                 1665             


Cys Asn  Gln Ala Ser Gln Arg  Ser Trp Asn Glu Phe  Asn Ser Gly 
    1670                 1675                 1680             


Pro Ser  Tyr Leu Trp Glu Ser  Pro Ala Thr Asp Pro  Ser Pro Ser 
    1685                 1690                 1695             


Trp Pro  Ala Ser Ser Gly Ser  Pro Thr His Thr Ala  Thr Ser Val 
    1700                 1705                 1710             


Leu Gly  Asn Thr Ser Gly Leu  Trp Ser Thr Thr Pro  Phe Ser Ser 
    1715                 1720                 1725             


Ser Ile  Trp Ser Ser Asn Leu  Ser Ser Ala Leu Pro  Phe Thr Thr 
    1730                 1735                 1740             


Pro Ala  Asn Thr Leu Ala Ser  Ile Gly Leu Met Gly  Thr Glu Asn 
    1745                 1750                 1755             


Ser Pro  Ala Pro His Ala Pro  Ser Thr Ser Ser Pro  Ala Asp Asp 
    1760                 1765                 1770             


Leu Gly  Gln Thr Tyr Asn Pro  Trp Arg Ile Trp Ser  Pro Thr Ile 
    1775                 1780                 1785             


Gly Arg  Arg Ser Ser Asp Pro  Trp Ser Asn Ser His  Phe Pro His 
    1790                 1795                 1800             


Glu Asn  
    1805 


<210>  211
<211>  5038
<212>  PRT
<213>  homo sapiens

<400>  211

Met Gly Asp Ala Glu Gly Glu Asp Glu Val Gln Phe Leu Arg Thr Asp 
1               5                   10                  15      


Asp Glu Val Val Leu Gln Cys Ser Ala Thr Val Leu Lys Glu Gln Leu 
            20                  25                  30          


Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe Leu 
        35                  40                  45              


Glu Pro Thr Ser Asn Ala Gln Asn Val Pro Pro Asp Leu Ala Ile Cys 
    50                  55                  60                  


Cys Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu Met 
65                  70                  75                  80  


Leu Ala Asn Thr Val Glu Ala Gly Val Glu Ser Ser Gln Gly Gly Gly 
                85                  90                  95      


His Arg Thr Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ala His 
            100                 105                 110         


Ser Arg Met Tyr Leu Ser Cys Leu Thr Thr Ser Arg Ser Met Thr Asp 
        115                 120                 125             


Lys Leu Ala Phe Asp Val Gly Leu Gln Glu Asp Ala Thr Gly Glu Ala 
    130                 135                 140                 


Cys Trp Trp Thr Met His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu 
145                 150                 155                 160 


Lys Val Arg Val Gly Asp Asp Ile Ile Leu Val Ser Val Ser Ser Glu 
                165                 170                 175     


Arg Tyr Leu His Leu Ser Thr Ala Ser Gly Glu Leu Gln Val Asp Ala 
            180                 185                 190         


Ser Phe Met Gln Thr Leu Trp Asn Met Asn Pro Ile Cys Ser Arg Cys 
        195                 200                 205             


Glu Glu Gly Phe Val Thr Gly Gly His Val Leu Arg Leu Phe His Gly 
    210                 215                 220                 


His Met Asp Glu Cys Leu Thr Ile Ser Pro Ala Asp Ser Asp Asp Gln 
225                 230                 235                 240 


Arg Arg Leu Val Tyr Tyr Glu Gly Gly Ala Val Cys Thr His Ala Arg 
                245                 250                 255     


Ser Leu Trp Arg Leu Glu Pro Leu Arg Ile Ser Trp Ser Gly Ser His 
            260                 265                 270         


Leu Arg Trp Gly Gln Pro Leu Arg Val Arg His Val Thr Thr Gly Gln 
        275                 280                 285             


Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Val Val Val Asp Ala Ser 
    290                 295                 300                 


Lys Ala His Thr Lys Ala Thr Ser Phe Cys Phe Arg Ile Ser Lys Glu 
305                 310                 315                 320 


Lys Leu Asp Val Ala Pro Lys Arg Asp Val Glu Gly Met Gly Pro Pro 
                325                 330                 335     


Glu Ile Lys Tyr Gly Glu Ser Leu Cys Phe Val Gln His Val Ala Ser 
            340                 345                 350         


Gly Leu Trp Leu Thr Tyr Ala Ala Pro Asp Pro Lys Ala Leu Arg Leu 
        355                 360                 365             


Gly Val Leu Lys Lys Lys Ala Met Leu His Gln Glu Gly His Met Asp 
    370                 375                 380                 


Asp Ala Leu Ser Leu Thr Arg Cys Gln Gln Glu Glu Ser Gln Ala Ala 
385                 390                 395                 400 


Arg Met Ile His Ser Thr Asn Gly Leu Tyr Asn Gln Phe Ile Lys Ser 
                405                 410                 415     


Leu Asp Ser Phe Ser Gly Lys Pro Arg Gly Ser Gly Pro Pro Ala Gly 
            420                 425                 430         


Thr Ala Leu Pro Ile Glu Gly Val Ile Leu Ser Leu Gln Asp Leu Ile 
        435                 440                 445             


Ile Tyr Phe Glu Pro Pro Ser Glu Asp Leu Gln His Glu Glu Lys Gln 
    450                 455                 460                 


Ser Lys Leu Arg Ser Leu Arg Asn Arg Gln Ser Leu Phe Gln Glu Glu 
465                 470                 475                 480 


Gly Met Leu Ser Met Val Leu Asn Cys Ile Asp Arg Leu Asn Val Tyr 
                485                 490                 495     


Thr Thr Ala Ala His Phe Ala Glu Phe Ala Gly Glu Glu Ala Ala Glu 
            500                 505                 510         


Ser Trp Lys Glu Ile Val Asn Leu Leu Tyr Glu Leu Leu Ala Ser Leu 
        515                 520                 525             


Ile Arg Gly Asn Arg Ser Asn Cys Ala Leu Phe Ser Thr Asn Leu Asp 
    530                 535                 540                 


Trp Leu Val Ser Lys Leu Asp Arg Leu Glu Ala Ser Ser Gly Ile Leu 
545                 550                 555                 560 


Glu Val Leu Tyr Cys Val Leu Ile Glu Ser Pro Glu Val Leu Asn Ile 
                565                 570                 575     


Ile Gln Glu Asn His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His 
            580                 585                 590         


Gly Arg Asn His Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys 
        595                 600                 605             


Asn Gly Val Ala Val Arg Ser Asn Gln Asp Leu Ile Thr Glu Asn Leu 
    610                 615                 620                 


Leu Pro Gly Arg Glu Leu Leu Leu Gln Thr Asn Leu Ile Asn Tyr Val 
625                 630                 635                 640 


Thr Ser Ile Arg Pro Asn Ile Phe Val Gly Arg Ala Glu Gly Thr Thr 
                645                 650                 655     


Gln Tyr Ser Lys Trp Tyr Phe Glu Val Met Val Asp Glu Val Thr Pro 
            660                 665                 670         


Phe Leu Thr Ala Gln Ala Thr His Leu Arg Val Gly Trp Ala Leu Thr 
        675                 680                 685             


Glu Gly Tyr Thr Pro Tyr Pro Gly Ala Gly Glu Gly Trp Gly Gly Asn 
    690                 695                 700                 


Gly Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu 
705                 710                 715                 720 


Trp Thr Gly His Val Ala Arg Pro Val Thr Ser Pro Gly Gln His Leu 
                725                 730                 735     


Leu Ala Pro Glu Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Val Pro 
            740                 745                 750         


Ser Ile Ser Phe Arg Ile Asn Gly Cys Pro Val Gln Gly Val Phe Glu 
        755                 760                 765             


Ser Phe Asn Leu Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala 
    770                 775                 780                 


Gly Val Lys Val Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys 
785                 790                 795                 800 


Phe Leu Pro Pro Pro Gly Tyr Ala Pro Cys His Glu Ala Val Leu Pro 
                805                 810                 815     


Arg Glu Arg Leu His Leu Glu Pro Ile Lys Glu Tyr Arg Arg Glu Gly 
            820                 825                 830         


Pro Arg Gly Pro His Leu Val Gly Pro Ser Arg Cys Leu Ser His Thr 
        835                 840                 845             


Asp Phe Val Pro Cys Pro Val Asp Thr Val Gln Ile Val Leu Pro Pro 
    850                 855                 860                 


His Leu Glu Arg Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu 
865                 870                 875                 880 


Trp Ala Leu Thr Arg Ile Glu Gln Gly Trp Thr Tyr Gly Pro Val Arg 
                885                 890                 895     


Asp Asp Asn Lys Arg Leu His Pro Cys Leu Val Asp Phe His Ser Leu 
            900                 905                 910         


Pro Glu Pro Glu Arg Asn Tyr Asn Leu Gln Met Ser Gly Glu Thr Leu 
        915                 920                 925             


Lys Thr Leu Leu Ala Leu Gly Cys His Val Gly Met Ala Asp Glu Lys 
    930                 935                 940                 


Ala Glu Asp Asn Leu Lys Lys Thr Lys Leu Pro Lys Thr Tyr Met Met 
945                 950                 955                 960 


Ser Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser His Val Arg Leu 
                965                 970                 975     


Thr Pro Ala Gln Thr Thr Leu Val Asp Arg Leu Ala Glu Asn Gly His 
            980                 985                 990         


Asn Val Trp Ala Arg Asp Arg Val  Gly Gln Gly Trp Ser  Tyr Ser Ala 
        995                 1000                 1005             


Val Gln  Asp Ile Pro Ala Arg  Arg Asn Pro Arg Leu  Val Pro Tyr 
    1010                 1015                 1020             


Arg Leu  Leu Asp Glu Ala Thr  Lys Arg Ser Asn Arg  Asp Ser Leu 
    1025                 1030                 1035             


Cys Gln  Ala Val Arg Thr Leu  Leu Gly Tyr Gly Tyr  Asn Ile Glu 
    1040                 1045                 1050             


Pro Pro  Asp Gln Glu Pro Ser  Gln Val Glu Asn Gln  Ser Arg Cys 
    1055                 1060                 1065             


Asp Arg  Val Arg Ile Phe Arg  Ala Glu Lys Ser Tyr  Thr Val Gln 
    1070                 1075                 1080             


Ser Gly  Arg Trp Tyr Phe Glu  Phe Glu Ala Val Thr  Thr Gly Glu 
    1085                 1090                 1095             


Met Arg  Val Gly Trp Ala Arg  Pro Glu Leu Arg Pro  Asp Val Glu 
    1100                 1105                 1110             


Leu Gly  Ala Asp Glu Leu Ala  Tyr Val Phe Asn Gly  His Arg Gly 
    1115                 1120                 1125             


Gln Arg  Trp His Leu Gly Ser  Glu Pro Phe Gly Arg  Pro Trp Gln 
    1130                 1135                 1140             


Pro Gly  Asp Val Val Gly Cys  Met Ile Asp Leu Thr  Glu Asn Thr 
    1145                 1150                 1155             


Ile Ile  Phe Thr Leu Asn Gly  Glu Val Leu Met Ser  Asp Ser Gly 
    1160                 1165                 1170             


Ser Glu  Thr Ala Phe Arg Glu  Ile Glu Ile Gly Asp  Gly Phe Leu 
    1175                 1180                 1185             


Pro Val  Cys Ser Leu Gly Pro  Gly Gln Val Gly His  Leu Asn Leu 
    1190                 1195                 1200             


Gly Gln  Asp Val Ser Ser Leu  Arg Phe Phe Ala Ile  Cys Gly Leu 
    1205                 1210                 1215             


Gln Glu  Gly Phe Glu Pro Phe  Ala Ile Asn Met Gln  Arg Pro Val 
    1220                 1225                 1230             


Thr Thr  Trp Phe Ser Lys Gly  Leu Pro Gln Phe Glu  Pro Val Pro 
    1235                 1240                 1245             


Leu Glu  His Pro His Tyr Glu  Val Ser Arg Val Asp  Gly Thr Val 
    1250                 1255                 1260             


Asp Thr  Pro Pro Cys Leu Arg  Leu Thr His Arg Thr  Trp Gly Ser 
    1265                 1270                 1275             


Gln Asn  Ser Leu Val Glu Met  Leu Phe Leu Arg Leu  Ser Leu Pro 
    1280                 1285                 1290             


Val Gln  Phe His Gln His Phe  Arg Cys Thr Ala Gly  Ala Thr Pro 
    1295                 1300                 1305             


Leu Ala  Pro Pro Gly Leu Gln  Pro Pro Ala Glu Asp  Glu Ala Arg 
    1310                 1315                 1320             


Ala Ala  Glu Pro Asp Pro Asp  Tyr Glu Asn Leu Arg  Arg Ser Ala 
    1325                 1330                 1335             


Gly Gly  Trp Ser Glu Ala Glu  Asn Gly Lys Glu Gly  Thr Ala Lys 
    1340                 1345                 1350             


Glu Gly  Ala Pro Gly Gly Thr  Pro Gln Ala Gly Gly  Glu Ala Gln 
    1355                 1360                 1365             


Pro Ala  Arg Ala Glu Asn Glu  Lys Asp Ala Thr Thr  Glu Lys Asn 
    1370                 1375                 1380             


Lys Lys  Arg Gly Phe Leu Phe  Lys Ala Lys Lys Val  Ala Met Met 
    1385                 1390                 1395             


Thr Gln  Pro Pro Ala Thr Pro  Thr Leu Pro Arg Leu  Pro His Asp 
    1400                 1405                 1410             


Val Val  Pro Ala Asp Asn Arg  Asp Asp Pro Glu Ile  Ile Leu Asn 
    1415                 1420                 1425             


Thr Thr  Thr Tyr Tyr Tyr Ser  Val Arg Val Phe Ala  Gly Gln Glu 
    1430                 1435                 1440             


Pro Ser  Cys Val Trp Ala Gly  Trp Val Thr Pro Asp  Tyr His Gln 
    1445                 1450                 1455             


His Asp  Met Ser Phe Asp Leu  Ser Lys Val Arg Val  Val Thr Val 
    1460                 1465                 1470             


Thr Met  Gly Asp Glu Gln Gly  Asn Val His Ser Ser  Leu Lys Cys 
    1475                 1480                 1485             


Ser Asn  Cys Tyr Met Val Trp  Gly Gly Asp Phe Val  Ser Pro Gly 
    1490                 1495                 1500             


Gln Gln  Gly Arg Ile Ser His  Thr Asp Leu Val Ile  Gly Cys Leu 
    1505                 1510                 1515             


Val Asp  Leu Ala Thr Gly Leu  Met Thr Phe Thr Ala  Asn Gly Lys 
    1520                 1525                 1530             


Glu Ser  Asn Thr Phe Phe Gln  Val Glu Pro Asn Thr  Lys Leu Phe 
    1535                 1540                 1545             


Pro Ala  Val Phe Val Leu Pro  Thr His Gln Asn Val  Ile Gln Phe 
    1550                 1555                 1560             


Glu Leu  Gly Lys Gln Lys Asn  Ile Met Pro Leu Ser  Ala Ala Met 
    1565                 1570                 1575             


Phe Gln  Ser Glu Arg Lys Asn  Pro Ala Pro Gln Cys  Pro Pro Arg 
    1580                 1585                 1590             


Leu Glu  Met Gln Met Leu Met  Pro Val Ser Trp Ser  Arg Met Pro 
    1595                 1600                 1605             


Asn His  Phe Leu Gln Val Glu  Thr Arg Arg Ala Gly  Glu Arg Leu 
    1610                 1615                 1620             


Gly Trp  Ala Val Gln Cys Gln  Glu Pro Leu Thr Met  Met Ala Leu 
    1625                 1630                 1635             


His Ile  Pro Glu Glu Asn Arg  Cys Met Asp Ile Leu  Glu Leu Ser 
    1640                 1645                 1650             


Glu Arg  Leu Asp Leu Gln Arg  Phe His Ser His Thr  Leu Arg Leu 
    1655                 1660                 1665             


Tyr Arg  Ala Val Cys Ala Leu  Gly Asn Asn Arg Val  Ala His Ala 
    1670                 1675                 1680             


Leu Cys  Ser His Val Asp Gln  Ala Gln Leu Leu His  Ala Leu Glu 
    1685                 1690                 1695             


Asp Ala  His Leu Pro Gly Pro  Leu Arg Ala Gly Tyr  Tyr Asp Leu 
    1700                 1705                 1710             


Leu Ile  Ser Ile His Leu Glu  Ser Ala Cys Arg Ser  Arg Arg Ser 
    1715                 1720                 1725             


Met Leu  Ser Glu Tyr Ile Val  Pro Leu Thr Pro Glu  Thr Arg Ala 
    1730                 1735                 1740             


Ile Thr  Leu Phe Pro Pro Gly  Arg Ser Thr Glu Asn  Gly His Pro 
    1745                 1750                 1755             


Arg His  Gly Leu Pro Gly Val  Gly Val Thr Thr Ser  Leu Arg Pro 
    1760                 1765                 1770             


Pro His  His Phe Ser Pro Pro  Cys Phe Val Ala Ala  Leu Pro Ala 
    1775                 1780                 1785             


Ala Gly  Ala Ala Glu Ala Pro  Ala Arg Leu Ser Pro  Ala Ile Pro 
    1790                 1795                 1800             


Leu Glu  Ala Leu Arg Asp Lys  Ala Leu Arg Met Leu  Gly Glu Ala 
    1805                 1810                 1815             


Val Arg  Asp Gly Gly Gln His  Ala Arg Asp Pro Val  Gly Gly Ser 
    1820                 1825                 1830             


Val Glu  Phe Gln Phe Val Pro  Val Leu Lys Leu Val  Ser Thr Leu 
    1835                 1840                 1845             


Leu Val  Met Gly Ile Phe Gly  Asp Glu Asp Val Lys  Gln Ile Leu 
    1850                 1855                 1860             


Lys Met  Ile Glu Pro Glu Val  Phe Thr Glu Glu Glu  Glu Glu Glu 
    1865                 1870                 1875             


Asp Glu  Glu Glu Glu Gly Glu  Glu Glu Asp Glu Glu  Glu Lys Glu 
    1880                 1885                 1890             


Glu Asp  Glu Glu Glu Thr Ala  Gln Glu Lys Glu Asp  Glu Glu Lys 
    1895                 1900                 1905             


Glu Glu  Glu Glu Ala Ala Glu  Gly Glu Lys Glu Glu  Gly Leu Glu 
    1910                 1915                 1920             


Glu Gly  Leu Leu Gln Met Lys  Leu Pro Glu Ser Val  Lys Leu Gln 
    1925                 1930                 1935             


Met Cys  His Leu Leu Glu Tyr  Phe Cys Asp Gln Glu  Leu Gln His 
    1940                 1945                 1950             


Arg Val  Glu Ser Leu Ala Ala  Phe Ala Glu Arg Tyr  Val Asp Lys 
    1955                 1960                 1965             


Leu Gln  Ala Asn Gln Arg Ser  Arg Tyr Gly Leu Leu  Ile Lys Ala 
    1970                 1975                 1980             


Phe Ser  Met Thr Ala Ala Glu  Thr Ala Arg Arg Thr  Arg Glu Phe 
    1985                 1990                 1995             


Arg Ser  Pro Pro Gln Glu Gln  Ile Asn Met Leu Leu  Gln Phe Lys 
    2000                 2005                 2010             


Asp Gly  Thr Asp Glu Glu Asp  Cys Pro Leu Pro Glu  Glu Ile Arg 
    2015                 2020                 2025             


Gln Asp  Leu Leu Asp Phe His  Gln Asp Leu Leu Ala  His Cys Gly 
    2030                 2035                 2040             


Ile Gln  Leu Asp Gly Glu Glu  Glu Glu Pro Glu Glu  Glu Thr Thr 
    2045                 2050                 2055             


Leu Gly  Ser Arg Leu Met Ser  Leu Leu Glu Lys Val  Arg Leu Val 
    2060                 2065                 2070             


Lys Lys  Lys Glu Glu Lys Pro  Glu Glu Glu Arg Ser  Ala Glu Glu 
    2075                 2080                 2085             


Ser Lys  Pro Arg Ser Leu Gln  Glu Leu Val Ser His  Met Val Val 
    2090                 2095                 2100             


Arg Trp  Ala Gln Glu Asp Phe  Val Gln Ser Pro Glu  Leu Val Arg 
    2105                 2110                 2115             


Ala Met  Phe Ser Leu Leu His  Arg Gln Tyr Asp Gly  Leu Gly Glu 
    2120                 2125                 2130             


Leu Leu  Arg Ala Leu Pro Arg  Ala Tyr Thr Ile Ser  Pro Ser Ser 
    2135                 2140                 2145             


Val Glu  Asp Thr Met Ser Leu  Leu Glu Cys Leu Gly  Gln Ile Arg 
    2150                 2155                 2160             


Ser Leu  Leu Ile Val Gln Met  Gly Pro Gln Glu Glu  Asn Leu Met 
    2165                 2170                 2175             


Ile Gln  Ser Ile Gly Asn Ile  Met Asn Asn Lys Val  Phe Tyr Gln 
    2180                 2185                 2190             


His Pro  Asn Leu Met Arg Ala  Leu Gly Met His Glu  Thr Val Met 
    2195                 2200                 2205             


Glu Val  Met Val Asn Val Leu  Gly Gly Gly Glu Ser  Lys Glu Ile 
    2210                 2215                 2220             


Arg Phe  Pro Lys Met Val Thr  Ser Cys Cys Arg Phe  Leu Cys Tyr 
    2225                 2230                 2235             


Phe Cys  Arg Ile Ser Arg Gln  Asn Gln Arg Ser Met  Phe Asp His 
    2240                 2245                 2250             


Leu Ser  Tyr Leu Leu Glu Asn  Ser Gly Ile Gly Leu  Gly Met Gln 
    2255                 2260                 2265             


Gly Ser  Thr Pro Leu Asp Val  Ala Ala Ala Ser Val  Ile Asp Asn 
    2270                 2275                 2280             


Asn Glu  Leu Ala Leu Ala Leu  Gln Glu Gln Asp Leu  Glu Lys Val 
    2285                 2290                 2295             


Val Ser  Tyr Leu Ala Gly Cys  Gly Leu Gln Ser Cys  Pro Met Leu 
    2300                 2305                 2310             


Val Ala  Lys Gly Tyr Pro Asp  Ile Gly Trp Asn Pro  Cys Gly Gly 
    2315                 2320                 2325             


Glu Arg  Tyr Leu Asp Phe Leu  Arg Phe Ala Val Phe  Val Asn Gly 
    2330                 2335                 2340             


Glu Ser  Val Glu Glu Asn Ala  Asn Val Val Val Arg  Leu Leu Ile 
    2345                 2350                 2355             


Arg Lys  Pro Glu Cys Phe Gly  Pro Ala Leu Arg Gly  Glu Gly Gly 
    2360                 2365                 2370             


Ser Gly  Leu Leu Ala Ala Ile  Glu Glu Ala Ile Arg  Ile Ser Glu 
    2375                 2380                 2385             


Asp Pro  Ala Arg Asp Gly Pro  Gly Ile Arg Arg Asp  Arg Arg Arg 
    2390                 2395                 2400             


Glu His  Phe Gly Glu Glu Pro  Pro Glu Glu Asn Arg  Val His Leu 
    2405                 2410                 2415             


Gly His  Ala Ile Met Ser Phe  Tyr Ala Ala Leu Ile  Asp Leu Leu 
    2420                 2425                 2430             


Gly Arg  Cys Ala Pro Glu Met  His Leu Ile Gln Ala  Gly Lys Gly 
    2435                 2440                 2445             


Glu Ala  Leu Arg Ile Arg Ala  Ile Leu Arg Ser Leu  Val Pro Leu 
    2450                 2455                 2460             


Glu Asp  Leu Val Gly Ile Ile  Ser Leu Pro Leu Gln  Ile Pro Thr 
    2465                 2470                 2475             


Leu Gly  Lys Asp Gly Ala Leu  Val Gln Pro Lys Met  Ser Ala Ser 
    2480                 2485                 2490             


Phe Val  Pro Asp His Lys Ala  Ser Met Val Leu Phe  Leu Asp Arg 
    2495                 2500                 2505             


Val Tyr  Gly Ile Glu Asn Gln  Asp Phe Leu Leu His  Val Leu Asp 
    2510                 2515                 2520             


Val Gly  Phe Leu Pro Asp Met  Arg Ala Ala Ala Ser  Leu Asp Thr 
    2525                 2530                 2535             


Ala Thr  Phe Ser Thr Thr Glu  Met Ala Leu Ala Leu  Asn Arg Tyr 
    2540                 2545                 2550             


Leu Cys  Leu Ala Val Leu Pro  Leu Ile Thr Lys Cys  Ala Pro Leu 
    2555                 2560                 2565             


Phe Ala  Gly Thr Glu His Arg  Ala Ile Met Val Asp  Ser Met Leu 
    2570                 2575                 2580             


His Thr  Val Tyr Arg Leu Ser  Arg Gly Arg Ser Leu  Thr Lys Ala 
    2585                 2590                 2595             


Gln Arg  Asp Val Ile Glu Asp  Cys Leu Met Ser Leu  Cys Arg Tyr 
    2600                 2605                 2610             


Ile Arg  Pro Ser Met Leu Gln  His Leu Leu Arg Arg  Leu Val Phe 
    2615                 2620                 2625             


Asp Val  Pro Ile Leu Asn Glu  Phe Ala Lys Met Pro  Leu Lys Leu 
    2630                 2635                 2640             


Leu Thr  Asn His Tyr Glu Arg  Cys Trp Lys Tyr Tyr  Cys Leu Pro 
    2645                 2650                 2655             


Thr Gly  Trp Ala Asn Phe Gly  Val Thr Ser Glu Glu  Glu Leu His 
    2660                 2665                 2670             


Leu Thr  Arg Lys Leu Phe Trp  Gly Ile Phe Asp Ser  Leu Ala His 
    2675                 2680                 2685             


Lys Lys  Tyr Asp Pro Glu Leu  Tyr Arg Met Ala Met  Pro Cys Leu 
    2690                 2695                 2700             


Cys Ala  Ile Ala Gly Ala Leu  Pro Pro Asp Tyr Val  Asp Ala Ser 
    2705                 2710                 2715             


Tyr Ser  Ser Lys Ala Glu Lys  Lys Ala Thr Val Asp  Ala Glu Gly 
    2720                 2725                 2730             


Asn Phe  Asp Pro Arg Pro Val  Glu Thr Leu Asn Val  Ile Ile Pro 
    2735                 2740                 2745             


Glu Lys  Leu Asp Ser Phe Ile  Asn Lys Phe Ala Glu  Tyr Thr His 
    2750                 2755                 2760             


Glu Lys  Trp Ala Phe Asp Lys  Ile Gln Asn Asn Trp  Ser Tyr Gly 
    2765                 2770                 2775             


Glu Asn  Ile Asp Glu Glu Leu  Lys Thr His Pro Met  Leu Arg Pro 
    2780                 2785                 2790             


Tyr Lys  Thr Phe Ser Glu Lys  Asp Lys Glu Ile Tyr  Arg Trp Pro 
    2795                 2800                 2805             


Ile Lys  Glu Ser Leu Lys Ala  Met Ile Ala Trp Glu  Trp Thr Ile 
    2810                 2815                 2820             


Glu Lys  Ala Arg Glu Gly Glu  Glu Glu Lys Thr Glu  Lys Lys Lys 
    2825                 2830                 2835             


Thr Arg  Lys Ile Ser Gln Ser  Ala Gln Thr Tyr Asp  Pro Arg Glu 
    2840                 2845                 2850             


Gly Tyr  Asn Pro Gln Pro Pro  Asp Leu Ser Ala Val  Thr Leu Ser 
    2855                 2860                 2865             


Arg Glu  Leu Gln Ala Met Ala  Glu Gln Leu Ala Glu  Asn Tyr His 
    2870                 2875                 2880             


Asn Thr  Trp Gly Arg Lys Lys  Lys Gln Glu Leu Glu  Ala Lys Gly 
    2885                 2890                 2895             


Gly Gly  Thr His Pro Leu Leu  Val Pro Tyr Asp Thr  Leu Thr Ala 
    2900                 2905                 2910             


Lys Glu  Lys Ala Arg Asp Arg  Glu Lys Ala Gln Glu  Leu Leu Lys 
    2915                 2920                 2925             


Phe Leu  Gln Met Asn Gly Tyr  Ala Val Thr Arg Gly  Leu Lys Asp 
    2930                 2935                 2940             


Met Glu  Leu Asp Ser Ser Ser  Ile Glu Lys Arg Phe  Ala Phe Gly 
    2945                 2950                 2955             


Phe Leu  Gln Gln Leu Leu Arg  Trp Met Asp Ile Ser  Gln Glu Phe 
    2960                 2965                 2970             


Ile Ala  His Leu Glu Ala Val  Val Ser Ser Gly Arg  Val Glu Lys 
    2975                 2980                 2985             


Ser Pro  His Glu Gln Glu Ile  Lys Phe Phe Ala Lys  Ile Leu Leu 
    2990                 2995                 3000             


Pro Leu  Ile Asn Gln Tyr Phe  Thr Asn His Cys Leu  Tyr Phe Leu 
    3005                 3010                 3015             


Ser Thr  Pro Ala Lys Val Leu  Gly Ser Gly Gly His  Ala Ser Asn 
    3020                 3025                 3030             


Lys Glu  Lys Glu Met Ile Thr  Ser Leu Phe Cys Lys  Leu Ala Ala 
    3035                 3040                 3045             


Leu Val  Arg His Arg Val Ser  Leu Phe Gly Thr Asp  Ala Pro Ala 
    3050                 3055                 3060             


Val Val  Asn Cys Leu His Ile  Leu Ala Arg Ser Leu  Asp Ala Arg 
    3065                 3070                 3075             


Thr Val  Met Lys Ser Gly Pro  Glu Ile Val Lys Ala  Gly Leu Arg 
    3080                 3085                 3090             


Ser Phe  Phe Glu Ser Ala Ser  Glu Asp Ile Glu Lys  Met Val Glu 
    3095                 3100                 3105             


Asn Leu  Arg Leu Gly Lys Val  Ser Gln Ala Arg Thr  Gln Val Lys 
    3110                 3115                 3120             


Gly Val  Gly Gln Asn Leu Thr  Tyr Thr Thr Val Ala  Leu Leu Pro 
    3125                 3130                 3135             


Val Leu  Thr Thr Leu Phe Gln  His Ile Ala Gln His  Gln Phe Gly 
    3140                 3145                 3150             


Asp Asp  Val Ile Leu Asp Asp  Val Gln Val Ser Cys  Tyr Arg Thr 
    3155                 3160                 3165             


Leu Cys  Ser Ile Tyr Ser Leu  Gly Thr Thr Lys Asn  Thr Tyr Val 
    3170                 3175                 3180             


Glu Lys  Leu Arg Pro Ala Leu  Gly Glu Cys Leu Ala  Arg Leu Ala 
    3185                 3190                 3195             


Ala Ala  Met Pro Val Ala Phe  Leu Glu Pro Gln Leu  Asn Glu Tyr 
    3200                 3205                 3210             


Asn Ala  Cys Ser Val Tyr Thr  Thr Lys Ser Pro Arg  Glu Arg Ala 
    3215                 3220                 3225             


Ile Leu  Gly Leu Pro Asn Ser  Val Glu Glu Met Cys  Pro Asp Ile 
    3230                 3235                 3240             


Pro Val  Leu Glu Arg Leu Met  Ala Asp Ile Gly Gly  Leu Ala Glu 
    3245                 3250                 3255             


Ser Gly  Ala Arg Tyr Thr Glu  Met Pro His Val Ile  Glu Ile Thr 
    3260                 3265                 3270             


Leu Pro  Met Leu Cys Ser Tyr  Leu Pro Arg Trp Trp  Glu Arg Gly 
    3275                 3280                 3285             


Pro Glu  Ala Pro Pro Ser Ala  Leu Pro Ala Gly Ala  Pro Pro Pro 
    3290                 3295                 3300             


Cys Thr  Ala Val Thr Ser Asp  His Leu Asn Ser Leu  Leu Gly Asn 
    3305                 3310                 3315             


Ile Leu  Arg Ile Ile Val Asn  Asn Leu Gly Ile Asp  Glu Ala Ser 
    3320                 3325                 3330             


Trp Met  Lys Arg Leu Ala Val  Phe Ala Gln Pro Ile  Val Ser Arg 
    3335                 3340                 3345             


Ala Arg  Pro Glu Leu Leu Gln  Ser His Phe Ile Pro  Thr Ile Gly 
    3350                 3355                 3360             


Arg Leu  Arg Lys Arg Ala Gly  Lys Val Val Ser Glu  Glu Glu Gln 
    3365                 3370                 3375             


Leu Arg  Leu Glu Ala Lys Ala  Glu Ala Gln Glu Gly  Glu Leu Leu 
    3380                 3385                 3390             


Val Arg  Asp Glu Phe Ser Val  Leu Cys Arg Asp Leu  Tyr Ala Leu 
    3395                 3400                 3405             


Tyr Pro  Leu Leu Ile Arg Tyr  Val Asp Asn Asn Arg  Ala Gln Trp 
    3410                 3415                 3420             


Leu Thr  Glu Pro Asn Pro Ser  Ala Glu Glu Leu Phe  Arg Met Val 
    3425                 3430                 3435             


Gly Glu  Ile Phe Ile Tyr Trp  Ser Lys Ser His Asn  Phe Lys Arg 
    3440                 3445                 3450             


Glu Glu  Gln Asn Phe Val Val  Gln Asn Glu Ile Asn  Asn Met Ser 
    3455                 3460                 3465             


Phe Leu  Thr Ala Asp Asn Lys  Ser Lys Met Ala Lys  Ala Gly Asp 
    3470                 3475                 3480             


Ile Gln  Ser Gly Gly Ser Asp  Gln Glu Arg Thr Lys  Lys Lys Arg 
    3485                 3490                 3495             


Arg Gly  Asp Arg Tyr Ser Val  Gln Thr Ser Leu Ile  Val Ala Thr 
    3500                 3505                 3510             


Leu Lys  Lys Met Leu Pro Ile  Gly Leu Asn Met Cys  Ala Pro Thr 
    3515                 3520                 3525             


Asp Gln  Asp Leu Ile Thr Leu  Ala Lys Thr Arg Tyr  Ala Leu Lys 
    3530                 3535                 3540             


Asp Thr  Asp Glu Glu Val Arg  Glu Phe Leu His Asn  Asn Leu His 
    3545                 3550                 3555             


Leu Gln  Gly Lys Val Glu Gly  Ser Pro Ser Leu Arg  Trp Gln Met 
    3560                 3565                 3570             


Ala Leu  Tyr Arg Gly Val Pro  Gly Arg Glu Glu Asp  Ala Asp Asp 
    3575                 3580                 3585             


Pro Glu  Lys Ile Val Arg Arg  Val Gln Glu Val Ser  Ala Val Leu 
    3590                 3595                 3600             


Tyr Tyr  Leu Asp Gln Thr Glu  His Pro Tyr Lys Ser  Lys Lys Ala 
    3605                 3610                 3615             


Val Trp  His Lys Leu Leu Ser  Lys Gln Arg Arg Arg  Ala Val Val 
    3620                 3625                 3630             


Ala Cys  Phe Arg Met Thr Pro  Leu Tyr Asn Leu Pro  Thr His Arg 
    3635                 3640                 3645             


Ala Cys  Asn Met Phe Leu Glu  Ser Tyr Lys Ala Ala  Trp Ile Leu 
    3650                 3655                 3660             


Thr Glu  Asp His Ser Phe Glu  Asp Arg Met Ile Asp  Asp Leu Ser 
    3665                 3670                 3675             


Lys Ala  Gly Glu Gln Glu Glu  Glu Glu Glu Glu Val  Glu Glu Lys 
    3680                 3685                 3690             


Lys Pro  Asp Pro Leu His Gln  Leu Val Leu His Phe  Ser Arg Thr 
    3695                 3700                 3705             


Ala Leu  Thr Glu Lys Ser Lys  Leu Asp Glu Asp Tyr  Leu Tyr Met 
    3710                 3715                 3720             


Ala Tyr  Ala Asp Ile Met Ala  Lys Ser Cys His Leu  Glu Glu Gly 
    3725                 3730                 3735             


Gly Glu  Asn Gly Glu Ala Glu  Glu Glu Val Glu Val  Ser Phe Glu 
    3740                 3745                 3750             


Glu Lys  Gln Met Glu Lys Gln  Arg Leu Leu Tyr Gln  Gln Ala Arg 
    3755                 3760                 3765             


Leu His  Thr Arg Gly Ala Ala  Glu Met Val Leu Gln  Met Ile Ser 
    3770                 3775                 3780             


Ala Cys  Lys Gly Glu Thr Gly  Ala Met Val Ser Ser  Thr Leu Lys 
    3785                 3790                 3795             


Leu Gly  Ile Ser Ile Leu Asn  Gly Gly Asn Ala Glu  Val Gln Gln 
    3800                 3805                 3810             


Lys Met  Leu Asp Tyr Leu Lys  Asp Lys Lys Glu Val  Gly Phe Phe 
    3815                 3820                 3825             


Gln Ser  Ile Gln Ala Leu Met  Gln Thr Cys Ser Val  Leu Asp Leu 
    3830                 3835                 3840             


Asn Ala  Phe Glu Arg Gln Asn  Lys Ala Glu Gly Leu  Gly Met Val 
    3845                 3850                 3855             


Asn Glu  Asp Gly Thr Val Ile  Asn Arg Gln Asn Gly  Glu Lys Val 
    3860                 3865                 3870             


Met Ala  Asp Asp Glu Phe Thr  Gln Asp Leu Phe Arg  Phe Leu Gln 
    3875                 3880                 3885             


Leu Leu  Cys Glu Gly His Asn  Asn Asp Phe Gln Asn  Tyr Leu Arg 
    3890                 3895                 3900             


Thr Gln  Thr Gly Asn Thr Thr  Thr Ile Asn Ile Ile  Ile Cys Thr 
    3905                 3910                 3915             


Val Asp  Tyr Leu Leu Arg Leu  Gln Glu Ser Ile Ser  Asp Phe Tyr 
    3920                 3925                 3930             


Trp Tyr  Tyr Ser Gly Lys Asp  Val Ile Glu Glu Gln  Gly Lys Arg 
    3935                 3940                 3945             


Asn Phe  Ser Lys Ala Met Ser  Val Ala Lys Gln Val  Phe Asn Ser 
    3950                 3955                 3960             


Leu Thr  Glu Tyr Ile Gln Gly  Pro Cys Thr Gly Asn  Gln Gln Ser 
    3965                 3970                 3975             


Leu Ala  His Ser Arg Leu Trp  Asp Ala Val Val Gly  Phe Leu His 
    3980                 3985                 3990             


Val Phe  Ala His Met Met Met  Lys Leu Ala Gln Asp  Ser Ser Gln 
    3995                 4000                 4005             


Ile Glu  Leu Leu Lys Glu Leu  Leu Asp Leu Gln Lys  Asp Met Val 
    4010                 4015                 4020             


Val Met  Leu Leu Ser Leu Leu  Glu Gly Asn Val Val  Asn Gly Met 
    4025                 4030                 4035             


Ile Ala  Arg Gln Met Val Asp  Met Leu Val Glu Ser  Ser Ser Asn 
    4040                 4045                 4050             


Val Glu  Met Ile Leu Lys Phe  Phe Asp Met Phe Leu  Lys Leu Lys 
    4055                 4060                 4065             


Asp Ile  Val Gly Ser Glu Ala  Phe Gln Asp Tyr Val  Thr Asp Pro 
    4070                 4075                 4080             


Arg Gly  Leu Ile Ser Lys Lys  Asp Phe Gln Lys Ala  Met Asp Ser 
    4085                 4090                 4095             


Gln Lys  Gln Phe Ser Gly Pro  Glu Ile Gln Phe Leu  Leu Ser Cys 
    4100                 4105                 4110             


Ser Glu  Ala Asp Glu Asn Glu  Met Ile Asn Cys Glu  Glu Phe Ala 
    4115                 4120                 4125             


Asn Arg  Phe Gln Glu Pro Ala  Arg Asp Ile Gly Phe  Asn Val Ala 
    4130                 4135                 4140             


Val Leu  Leu Thr Asn Leu Ser  Glu His Val Pro His  Asp Pro Arg 
    4145                 4150                 4155             


Leu His  Asn Phe Leu Glu Leu  Ala Glu Ser Ile Leu  Glu Tyr Phe 
    4160                 4165                 4170             


Arg Pro  Tyr Leu Gly Arg Ile  Glu Ile Met Gly Ala  Ser Arg Arg 
    4175                 4180                 4185             


Ile Glu  Arg Ile Tyr Phe Glu  Ile Ser Glu Thr Asn  Arg Ala Gln 
    4190                 4195                 4200             


Trp Glu  Met Pro Gln Val Lys  Glu Ser Lys Arg Gln  Phe Ile Phe 
    4205                 4210                 4215             


Asp Val  Val Asn Glu Gly Gly  Glu Ala Glu Lys Met  Glu Leu Phe 
    4220                 4225                 4230             


Val Ser  Phe Cys Glu Asp Thr  Ile Phe Glu Met Gln  Ile Ala Ala 
    4235                 4240                 4245             


Gln Ile  Ser Glu Pro Glu Gly  Glu Pro Glu Thr Asp  Glu Asp Glu 
    4250                 4255                 4260             


Gly Ala  Gly Ala Ala Glu Ala  Gly Ala Glu Gly Ala  Glu Glu Gly 
    4265                 4270                 4275             


Ala Ala  Gly Leu Glu Gly Thr  Ala Ala Thr Ala Ala  Ala Gly Ala 
    4280                 4285                 4290             


Thr Ala  Arg Val Val Ala Ala  Ala Gly Arg Ala Leu  Arg Gly Leu 
    4295                 4300                 4305             


Ser Tyr  Arg Ser Leu Arg Arg  Arg Val Arg Arg Leu  Arg Arg Leu 
    4310                 4315                 4320             


Thr Ala  Arg Glu Ala Ala Thr  Ala Val Ala Ala Leu  Leu Trp Ala 
    4325                 4330                 4335             


Ala Val  Thr Arg Ala Gly Ala  Ala Gly Ala Gly Ala  Ala Ala Gly 
    4340                 4345                 4350             


Ala Leu  Gly Leu Leu Trp Gly  Ser Leu Phe Gly Gly  Gly Leu Val 
    4355                 4360                 4365             


Glu Gly  Ala Lys Lys Val Thr  Val Thr Glu Leu Leu  Ala Gly Met 
    4370                 4375                 4380             


Pro Asp  Pro Thr Ser Asp Glu  Val His Gly Glu Gln  Pro Ala Gly 
    4385                 4390                 4395             


Pro Gly  Gly Asp Ala Asp Gly  Glu Gly Ala Ser Glu  Gly Ala Gly 
    4400                 4405                 4410             


Asp Ala  Ala Glu Gly Ala Gly  Asp Glu Glu Glu Ala  Val His Glu 
    4415                 4420                 4425             


Ala Gly  Pro Gly Gly Ala Asp  Gly Ala Val Ala Val  Thr Asp Gly 
    4430                 4435                 4440             


Gly Pro  Phe Arg Pro Glu Gly  Ala Gly Gly Leu Gly  Asp Met Gly 
    4445                 4450                 4455             


Asp Thr  Thr Pro Ala Glu Pro  Pro Thr Pro Glu Gly  Ser Pro Ile 
    4460                 4465                 4470             


Leu Lys  Arg Lys Leu Gly Val  Asp Gly Val Glu Glu  Glu Leu Pro 
    4475                 4480                 4485             


Pro Glu  Pro Glu Pro Glu Pro  Glu Pro Glu Leu Glu  Pro Glu Lys 
    4490                 4495                 4500             


Ala Asp  Ala Glu Asn Gly Glu  Lys Glu Glu Val Pro  Glu Pro Thr 
    4505                 4510                 4515             


Pro Glu  Pro Pro Lys Lys Gln  Ala Pro Pro Ser Pro  Pro Pro Lys 
    4520                 4525                 4530             


Lys Glu  Glu Ala Gly Gly Glu  Phe Trp Gly Glu Leu  Glu Val Gln 
    4535                 4540                 4545             


Arg Val  Lys Phe Leu Asn Tyr  Leu Ser Arg Asn Phe  Tyr Thr Leu 
    4550                 4555                 4560             


Arg Phe  Leu Ala Leu Phe Leu  Ala Phe Ala Ile Asn  Phe Ile Leu 
    4565                 4570                 4575             


Leu Phe  Tyr Lys Val Ser Asp  Ser Pro Pro Gly Glu  Asp Asp Met 
    4580                 4585                 4590             


Glu Gly  Ser Ala Ala Gly Asp  Val Ser Gly Ala Gly  Ser Gly Gly 
    4595                 4600                 4605             


Ser Ser  Gly Trp Gly Leu Gly  Ala Gly Glu Glu Ala  Glu Gly Asp 
    4610                 4615                 4620             


Glu Asp  Glu Asn Met Val Tyr  Tyr Phe Leu Glu Glu  Ser Thr Gly 
    4625                 4630                 4635             


Tyr Met  Glu Pro Ala Leu Arg  Cys Leu Ser Leu Leu  His Thr Leu 
    4640                 4645                 4650             


Val Ala  Phe Leu Cys Ile Ile  Gly Tyr Asn Cys Leu  Lys Val Pro 
    4655                 4660                 4665             


Leu Val  Ile Phe Lys Arg Glu  Lys Glu Leu Ala Arg  Lys Leu Glu 
    4670                 4675                 4680             


Phe Asp  Gly Leu Tyr Ile Thr  Glu Gln Pro Glu Asp  Asp Asp Val 
    4685                 4690                 4695             


Lys Gly  Gln Trp Asp Arg Leu  Val Leu Asn Thr Pro  Ser Phe Pro 
    4700                 4705                 4710             


Ser Asn  Tyr Trp Asp Lys Phe  Val Lys Arg Lys Val  Leu Asp Lys 
    4715                 4720                 4725             


His Gly  Asp Ile Tyr Gly Arg  Glu Arg Ile Ala Glu  Leu Leu Gly 
    4730                 4735                 4740             


Met Asp  Leu Ala Thr Leu Glu  Ile Thr Ala His Asn  Glu Arg Lys 
    4745                 4750                 4755             


Pro Asn  Pro Pro Pro Gly Leu  Leu Thr Trp Leu Met  Ser Ile Asp 
    4760                 4765                 4770             


Val Lys  Tyr Gln Ile Trp Lys  Phe Gly Val Ile Phe  Thr Asp Asn 
    4775                 4780                 4785             


Ser Phe  Leu Tyr Leu Gly Trp  Tyr Met Val Met Ser  Leu Leu Gly 
    4790                 4795                 4800             


His Tyr  Asn Asn Phe Phe Phe  Ala Ala His Leu Leu  Asp Ile Ala 
    4805                 4810                 4815             


Met Gly  Val Lys Thr Leu Arg  Thr Ile Leu Ser Ser  Val Thr His 
    4820                 4825                 4830             


Asn Gly  Lys Gln Leu Val Met  Thr Val Gly Leu Leu  Ala Val Val 
    4835                 4840                 4845             


Val Tyr  Leu Tyr Thr Val Val  Ala Phe Asn Phe Phe  Arg Lys Phe 
    4850                 4855                 4860             


Tyr Asn  Lys Ser Glu Asp Glu  Asp Glu Pro Asp Met  Lys Cys Asp 
    4865                 4870                 4875             


Asp Met  Met Thr Cys Tyr Leu  Phe His Met Tyr Val  Gly Val Arg 
    4880                 4885                 4890             


Ala Gly  Gly Gly Ile Gly Asp  Glu Ile Glu Asp Pro  Ala Gly Asp 
    4895                 4900                 4905             


Glu Tyr  Glu Leu Tyr Arg Val  Val Phe Asp Ile Thr  Phe Phe Phe 
    4910                 4915                 4920             


Phe Val  Ile Val Ile Leu Leu  Ala Ile Ile Gln Gly  Leu Ile Ile 
    4925                 4930                 4935             


Asp Ala  Phe Gly Glu Leu Arg  Asp Gln Gln Glu Gln  Val Lys Glu 
    4940                 4945                 4950             


Asp Met  Glu Thr Lys Cys Phe  Ile Cys Gly Ile Gly  Ser Asp Tyr 
    4955                 4960                 4965             


Phe Asp  Thr Thr Pro His Gly  Phe Glu Thr His Thr  Leu Glu Glu 
    4970                 4975                 4980             


His Asn  Leu Ala Asn Tyr Met  Phe Phe Leu Met Tyr  Leu Ile Asn 
    4985                 4990                 4995             


Lys Asp  Glu Thr Glu His Thr  Gly Gln Glu Ser Tyr  Val Trp Lys 
    5000                 5005                 5010             


Met Tyr  Gln Glu Arg Cys Trp  Asp Phe Phe Pro Ala  Gly Asp Cys 
    5015                 5020                 5025             


Phe Arg  Lys Gln Tyr Glu Asp  Gln Leu Ser 
    5030                 5035             


<210>  212
<211>  4870
<212>  PRT
<213>  homo sapiens

<400>  212

Met Ala Glu Gly Gly Glu Gly Gly Glu Asp Glu Ile Gln Phe Leu Arg 
1               5                   10                  15      


Thr Glu Asp Glu Val Val Leu Gln Cys Ile Ala Thr Ile His Lys Glu 
            20                  25                  30          


Gln Arg Lys Phe Cys Leu Ala Ala Glu Gly Leu Gly Asn Arg Leu Cys 
        35                  40                  45              


Phe Leu Glu Pro Thr Ser Glu Ala Lys Tyr Ile Pro Pro Asp Leu Cys 
    50                  55                  60                  


Val Cys Asn Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln 
65                  70                  75                  80  


Glu Met Leu Ala Asn Thr Gly Glu Asn Gly Gly Glu Gly Ala Ala Gln 
                85                  90                  95      


Gly Gly Gly His Arg Thr Leu Leu Tyr Gly His Ala Val Leu Leu Arg 
            100                 105                 110         


His Ser Phe Ser Gly Met Tyr Leu Thr Cys Leu Thr Thr Ser Arg Ser 
        115                 120                 125             


Gln Thr Asp Lys Leu Ala Phe Asp Val Gly Leu Arg Glu His Ala Thr 
    130                 135                 140                 


Gly Glu Ala Cys Trp Trp Thr Ile His Pro Ala Ser Lys Gln Arg Ser 
145                 150                 155                 160 


Glu Gly Glu Lys Val Arg Ile Gly Asp Asp Leu Ile Leu Val Ser Val 
                165                 170                 175     


Ser Ser Glu Arg Tyr Leu His Leu Ser Val Ser Asn Gly Asn Ile Gln 
            180                 185                 190         


Val Asp Ala Ser Phe Met Gln Thr Leu Trp Asn Val His Pro Thr Cys 
        195                 200                 205             


Ser Gly Ser Ser Ile Glu Glu Gly Tyr Leu Leu Gly Gly His Val Val 
    210                 215                 220                 


Arg Leu Phe His Gly His Asp Glu Cys Leu Thr Ile Pro Ser Thr Asp 
225                 230                 235                 240 


Gln Asn Asp Ser Gln His Arg Arg Ile Phe Tyr Glu Ala Gly Gly Ala 
                245                 250                 255     


Gly Thr Arg Ala Ser Ser Leu Trp Arg Val Glu Pro Leu Arg Ile Ser 
            260                 265                 270         


Trp Ser Gly Ser Asn Ile Arg Trp Gly Gln Ala Phe Arg Leu Arg His 
        275                 280                 285             


Leu Thr Thr Gly His Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Ile 
    290                 295                 300                 


Leu Gln Asp Arg Ala Lys Ser Asp Thr Lys Ser Thr Ala Phe Ser Phe 
305                 310                 315                 320 


Arg Ala Ser Lys Glu Leu Lys Glu Lys Leu Asp Ser Ser His Lys Arg 
                325                 330                 335     


Asp Ile Glu Gly Met Gly Val Pro Glu Ile Lys Tyr Gly Asp Ser Val 
            340                 345                 350         


Cys Phe Val Gln His Ile Ala Ser Gly Leu Trp Val Thr Tyr Lys Ala 
        355                 360                 365             


Gln Asp Ala Lys Thr Ser Arg Leu Gly Pro Leu Lys Arg Lys Val Ile 
    370                 375                 380                 


Leu His Gln Glu Gly His Met Asp Asp Gly Leu Thr Leu Gln Arg Cys 
385                 390                 395                 400 


Gln Arg Glu Glu Ser Gln Ala Ala Arg Ile Ile Arg Asn Thr Thr Ala 
                405                 410                 415     


Leu Phe Ser Gln Phe Val Ser Gly Asn Asn Arg Thr Ala Ala Pro Ile 
            420                 425                 430         


Thr Leu Pro Ile Glu Glu Val Leu Gln Thr Leu Gln Asp Leu Ile Ala 
        435                 440                 445             


Tyr Phe Gln Pro Pro Glu Glu Glu Met Arg His Glu Asp Lys Gln Asn 
    450                 455                 460                 


Lys Leu Arg Ser Leu Lys Asn Arg Gln Asn Leu Phe Lys Glu Glu Gly 
465                 470                 475                 480 


Met Leu Ala Leu Val Leu Asn Cys Ile Asp Arg Leu Asn Ile Tyr Asn 
                485                 490                 495     


Ser Val Ala His Phe Ala Gly Ile Ala Arg Glu Glu Ser Gly Met Ala 
            500                 505                 510         


Trp Lys Glu Ile Leu Asn Leu Leu Tyr Lys Leu Leu Ala Ala Leu Ile 
        515                 520                 525             


Arg Gly Asn Arg Asn Asn Cys Ala Gln Phe Ser Asn Asn Leu Asp Trp 
    530                 535                 540                 


Leu Ile Ser Lys Leu Asp Arg Leu Glu Ser Ser Ser Gly Ile Leu Glu 
545                 550                 555                 560 


Val Leu His Cys Ile Leu Thr Glu Ser Pro Glu Ala Leu Asn Leu Ile 
                565                 570                 575     


Ala Glu Gly His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His Gly 
            580                 585                 590         


Arg Asn His Lys Val Leu Asp Ile Leu Cys Ser Leu Cys Leu Cys Asn 
        595                 600                 605             


Gly Val Ala Val Arg Ala Asn Gln Asn Leu Ile Cys Asp Asn Leu Leu 
    610                 615                 620                 


Pro Arg Arg Asn Leu Leu Leu Gln Thr Arg Leu Ile Asn Asp Val Thr 
625                 630                 635                 640 


Ser Ile Arg Pro Asn Ile Phe Leu Gly Val Ala Glu Gly Ser Ala Gln 
                645                 650                 655     


Tyr Lys Lys Trp Tyr Phe Glu Leu Ile Ile Asp Gln Val Asp Pro Phe 
            660                 665                 670         


Leu Thr Ala Glu Pro Thr His Leu Arg Val Gly Trp Ala Ser Ser Ser 
        675                 680                 685             


Gly Tyr Ala Pro Cys Pro Gly Gly Gly Glu Gly Trp Gly Gly Asn Gly 
    690                 695                 700                 


Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu Trp 
705                 710                 715                 720 


Ser Gly Arg Ile Pro Arg Ala Val Ala Ser Val Asn Gln His Leu Leu 
                725                 730                 735     


Arg Ser Asp Asp Val Val Ser Cys Cys Leu Asp Leu Gly Val Pro Ser 
            740                 745                 750         


Ile Ser Phe Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe Glu Asn 
        755                 760                 765             


Phe Asn Thr Asp Gly Leu Phe Phe Pro Val Met Ser Phe Ser Ala Gly 
    770                 775                 780                 


Val Lys Val Arg Phe Leu Met Gly Gly Arg His Gly Glu Phe Lys Phe 
785                 790                 795                 800 


Leu Pro Pro Ser Gly Tyr Ala Pro Cys Tyr Glu Ala Leu Leu Pro Lys 
                805                 810                 815     


Glu Lys Met Arg Leu Glu Pro Val Lys Glu Tyr Lys Arg Asp Ala Asp 
            820                 825                 830         


Gly Ile Arg Asp Leu Leu Gly Thr Thr Gln Phe Leu Ser Gln Ala Ser 
        835                 840                 845             


Phe Ile Pro Cys Pro Val Asp Thr Ser Gln Val Ile Leu Pro Pro His 
    850                 855                 860                 


Leu Glu Lys Ile Arg Asp Arg Leu Ala Glu Asn Ile His Glu Leu Trp 
865                 870                 875                 880 


Gly Met Asn Lys Ile Glu Leu Gly Trp Thr Phe Gly Lys Ile Arg Asp 
                885                 890                 895     


Asp Asn Lys Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro 
            900                 905                 910         


Glu Thr Glu Lys Asn Tyr Asn Leu Gln Met Ser Thr Glu Thr Leu Lys 
        915                 920                 925             


Thr Leu Leu Ala Leu Gly Cys His Ile Ala His Val Asn Pro Ala Ala 
    930                 935                 940                 


Glu Glu Asp Leu Lys Lys Val Lys Leu Pro Lys Asn Tyr Met Met Ser 
945                 950                 955                 960 


Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser Asp Val Lys Leu Leu 
                965                 970                 975     


Pro Pro Gln Glu Ile Leu Val Asp Lys Leu Ala Glu Asn Ala His Asn 
            980                 985                 990         


Val Trp Ala Lys Asp Arg Ile Lys  Gln Gly Trp Thr Tyr  Gly Ile Gln 
        995                 1000                 1005             


Gln Asp  Leu Lys Asn Lys Arg  Asn Pro Arg Leu Val  Pro Tyr Ala 
    1010                 1015                 1020             


Leu Leu  Asp Glu Arg Thr Lys  Lys Ser Asn Arg Asp  Ser Leu Arg 
    1025                 1030                 1035             


Glu Ala  Val Arg Thr Phe Val  Gly Tyr Gly Tyr Asn  Ile Glu Pro 
    1040                 1045                 1050             


Ser Asp  Gln Glu Leu Ala Asp  Ser Ala Val Glu Lys  Val Ser Ile 
    1055                 1060                 1065             


Asp Lys  Ile Arg Phe Phe Arg  Val Glu Arg Ser Tyr  Ala Val Arg 
    1070                 1075                 1080             


Ser Gly  Lys Trp Tyr Phe Glu  Phe Glu Val Val Thr  Gly Gly Asp 
    1085                 1090                 1095             


Met Arg  Val Gly Trp Ala Arg  Pro Gly Cys Arg Pro  Asp Val Glu 
    1100                 1105                 1110             


Leu Gly  Ala Asp Asp Gln Ala  Phe Val Phe Glu Gly  Asn Arg Gly 
    1115                 1120                 1125             


Gln Arg  Trp His Gln Gly Ser  Gly Tyr Phe Gly Arg  Thr Trp Gln 
    1130                 1135                 1140             


Pro Gly  Asp Val Val Gly Cys  Met Ile Asn Leu Asp  Asp Ala Ser 
    1145                 1150                 1155             


Met Ile  Phe Thr Leu Asn Gly  Glu Leu Leu Ile Thr  Asn Lys Gly 
    1160                 1165                 1170             


Ser Glu  Leu Ala Phe Ala Asp  Tyr Glu Ile Glu Asn  Gly Phe Val 
    1175                 1180                 1185             


Pro Ile  Cys Cys Leu Gly Leu  Ser Gln Ile Gly Arg  Met Asn Leu 
    1190                 1195                 1200             


Gly Thr  Asp Ala Ser Thr Phe  Lys Phe Tyr Thr Met  Cys Gly Leu 
    1205                 1210                 1215             


Gln Glu  Gly Phe Glu Pro Phe  Ala Val Asn Met Asn  Arg Asp Val 
    1220                 1225                 1230             


Ala Met  Trp Phe Ser Lys Arg  Leu Pro Thr Phe Val  Asn Val Pro 
    1235                 1240                 1245             


Lys Asp  His Pro His Ile Glu  Val Met Arg Ile Asp  Gly Thr Met 
    1250                 1255                 1260             


Asp Ser  Pro Pro Cys Leu Lys  Val Thr His Lys Thr  Phe Gly Thr 
    1265                 1270                 1275             


Gln Asn  Ser Asn Ala Asp Met  Ile Tyr Cys Arg Leu  Ser Met Pro 
    1280                 1285                 1290             


Val Glu  Cys His Ser Ser Phe  Ser His Ser Pro Cys  Leu Asp Ser 
    1295                 1300                 1305             


Glu Ala  Phe Gln Lys Arg Lys  Gln Met Gln Glu Ile  Leu Ser His 
    1310                 1315                 1320             


Thr Thr  Thr Gln Cys Tyr Tyr  Ala Ile Arg Ile Phe  Ala Gly Gln 
    1325                 1330                 1335             


Asp Pro  Ser Cys Val Trp Val  Gly Trp Val Thr Pro  Asp Tyr His 
    1340                 1345                 1350             


Leu Tyr  Ser Glu Lys Phe Asp  Leu Asn Lys Asn Cys  Thr Val Thr 
    1355                 1360                 1365             


Val Thr  Leu Gly Asp Glu Arg  Gly Arg Val His Glu  Ser Val Lys 
    1370                 1375                 1380             


Arg Ser  Asn Cys Tyr Met Val  Trp Gly Gly Asp Ile  Val Ala Ser 
    1385                 1390                 1395             


Ser Gln  Arg Ser Asn Arg Ser  Asn Val Asp Leu Glu  Ile Gly Cys 
    1400                 1405                 1410             


Leu Val  Asp Leu Ala Met Gly  Met Leu Ser Phe Ser  Ala Asn Gly 
    1415                 1420                 1425             


Lys Glu  Leu Gly Thr Cys Tyr  Gln Val Glu Pro Asn  Thr Lys Val 
    1430                 1435                 1440             


Phe Pro  Ala Val Phe Leu Gln  Pro Thr Ser Thr Ser  Leu Phe Gln 
    1445                 1450                 1455             


Phe Glu  Leu Gly Lys Leu Lys  Asn Ala Met Pro Leu  Ser Ala Ala 
    1460                 1465                 1470             


Ile Phe  Arg Ser Glu Glu Lys  Asn Pro Val Pro Gln  Cys Pro Pro 
    1475                 1480                 1485             


Arg Leu  Asp Val Gln Thr Ile  Gln Pro Val Leu Trp  Ser Arg Met 
    1490                 1495                 1500             


Pro Asn  Ser Phe Leu Lys Val  Glu Thr Glu Arg Val  Ser Glu Arg 
    1505                 1510                 1515             


His Gly  Trp Val Val Gln Cys  Leu Glu Pro Leu Gln  Met Met Ala 
    1520                 1525                 1530             


Leu His  Ile Pro Glu Glu Asn  Arg Cys Val Asp Ile  Leu Glu Leu 
    1535                 1540                 1545             


Cys Glu  Gln Glu Asp Leu Met  Arg Phe His Tyr His  Thr Leu Arg 
    1550                 1555                 1560             


Leu Tyr  Ser Ala Val Cys Ala  Leu Gly Asn Ser Arg  Val Ala Tyr 
    1565                 1570                 1575             


Ala Leu  Cys Ser His Val Asp  Leu Ser Gln Leu Phe  Tyr Ala Ile 
    1580                 1585                 1590             


Asp Asn  Lys Tyr Leu Pro Gly  Leu Leu Arg Ser Gly  Phe Tyr Asp 
    1595                 1600                 1605             


Leu Leu  Ile Ser Ile His Leu  Ala Ser Ala Lys Glu  Arg Lys Leu 
    1610                 1615                 1620             


Met Met  Lys Asn Glu Tyr Ile  Ile Pro Ile Thr Ser  Thr Thr Arg 
    1625                 1630                 1635             


Asn Ile  Cys Leu Phe Pro Asp  Glu Ser Lys Arg His  Gly Leu Pro 
    1640                 1645                 1650             


Gly Val  Gly Leu Arg Thr Cys  Leu Lys Pro Gly Phe  Arg Phe Ser 
    1655                 1660                 1665             


Thr Pro  Cys Phe Val Val Thr  Gly Glu Asp His Gln  Lys Gln Ser 
    1670                 1675                 1680             


Pro Glu  Ile Pro Leu Glu Ser  Leu Arg Thr Lys Ala  Leu Ser Met 
    1685                 1690                 1695             


Leu Thr  Glu Ala Val Gln Cys  Ser Gly Ala His Ile  Arg Asp Pro 
    1700                 1705                 1710             


Val Gly  Gly Ser Val Glu Phe  Gln Phe Val Pro Val  Leu Lys Leu 
    1715                 1720                 1725             


Ile Gly  Thr Leu Leu Val Met  Gly Val Phe Asp Asp  Asp Asp Val 
    1730                 1735                 1740             


Arg Gln  Ile Leu Leu Leu Ile  Asp Pro Ser Val Phe  Gly Glu His 
    1745                 1750                 1755             


Ser Ala  Gly Thr Glu Glu Gly  Ala Glu Lys Glu Glu  Val Thr Gln 
    1760                 1765                 1770             


Val Glu  Glu Lys Ala Val Glu  Ala Gly Glu Lys Ala  Gly Lys Glu 
    1775                 1780                 1785             


Ala Pro  Val Lys Gly Leu Leu  Gln Thr Arg Leu Pro  Glu Ser Val 
    1790                 1795                 1800             


Lys Leu  Gln Met Cys Glu Leu  Leu Ser Tyr Leu Cys  Asp Cys Glu 
    1805                 1810                 1815             


Leu Gln  His Arg Val Glu Ala  Ile Val Ala Phe Gly  Asp Ile Tyr 
    1820                 1825                 1830             


Val Ser  Lys Leu Gln Ala Asn  Gln Lys Phe Arg Tyr  Asn Glu Leu 
    1835                 1840                 1845             


Met Gln  Ala Leu Asn Met Ser  Ala Ala Leu Thr Ala  Arg Lys Thr 
    1850                 1855                 1860             


Lys Glu  Phe Arg Ser Pro Pro  Gln Glu Gln Ile Asn  Met Leu Leu 
    1865                 1870                 1875             


Asn Phe  Gln Leu Gly Glu Asn  Cys Pro Cys Pro Glu  Glu Ile Arg 
    1880                 1885                 1890             


Glu Glu  Leu Tyr Asp Phe His  Glu Asp Leu Leu Leu  His Cys Gly 
    1895                 1900                 1905             


Val Pro  Leu Glu Glu Glu Glu  Glu Glu Glu Glu Asp  Thr Ser Trp 
    1910                 1915                 1920             


Thr Gly  Lys Leu Cys Ala Leu  Val Tyr Lys Ile Lys  Gly Pro Pro 
    1925                 1930                 1935             


Lys Pro  Glu Lys Glu Gln Pro  Thr Glu Glu Glu Glu  Arg Cys Pro 
    1940                 1945                 1950             


Thr Thr  Leu Lys Glu Leu Ile  Ser Gln Thr Met Ile  Cys Trp Ala 
    1955                 1960                 1965             


Gln Glu  Asp Gln Ile Gln Asp  Ser Glu Leu Val Arg  Met Met Phe 
    1970                 1975                 1980             


Asn Leu  Leu Arg Arg Gln Tyr  Asp Ser Ile Gly Glu  Leu Leu Gln 
    1985                 1990                 1995             


Ala Leu  Arg Lys Thr Tyr Thr  Ile Ser His Thr Ser  Val Ser Asp 
    2000                 2005                 2010             


Thr Ile  Asn Leu Leu Ala Ala  Leu Gly Gln Ile Arg  Ser Leu Leu 
    2015                 2020                 2025             


Ser Val  Arg Met Gly Lys Glu  Glu Glu Leu Leu Met  Ile Asn Gly 
    2030                 2035                 2040             


Leu Gly  Asp Ile Met Asn Asn  Lys Val Phe Tyr Gln  His Pro Asn 
    2045                 2050                 2055             


Leu Met  Arg Val Leu Gly Met  His Glu Thr Val Met  Glu Val Met 
    2060                 2065                 2070             


Val Asn  Val Leu Gly Thr Glu  Lys Ser Gln Ile Ala  Phe Pro Lys 
    2075                 2080                 2085             


Met Val  Ala Ser Cys Cys Arg  Phe Leu Cys Tyr Phe  Cys Arg Ile 
    2090                 2095                 2100             


Ser Arg  Gln Asn Gln Lys Ala  Met Phe Glu His Leu  Ser Tyr Leu 
    2105                 2110                 2115             


Leu Glu  Asn Ser Ser Val Gly  Leu Ala Ser Pro Ser  Met Arg Gly 
    2120                 2125                 2130             


Ser Thr  Pro Leu Asp Val Ala  Ala Ser Ser Val Met  Asp Asn Asn 
    2135                 2140                 2145             


Glu Leu  Ala Leu Ser Leu Glu  Glu Pro Asp Leu Glu  Lys Val Val 
    2150                 2155                 2160             


Thr Tyr  Leu Ala Gly Cys Gly  Leu Gln Ser Cys Pro  Met Leu Leu 
    2165                 2170                 2175             


Ala Lys  Gly Tyr Pro Asp Val  Gly Trp Asn Pro Ile  Glu Gly Glu 
    2180                 2185                 2190             


Arg Tyr  Leu Ser Phe Leu Arg  Phe Ala Val Phe Val  Asn Ser Glu 
    2195                 2200                 2205             


Ser Val  Glu Glu Asn Ala Ser  Val Val Val Lys Leu  Leu Ile Arg 
    2210                 2215                 2220             


Arg Pro  Glu Cys Phe Gly Pro  Ala Leu Arg Gly Glu  Gly Gly Asn 
    2225                 2230                 2235             


Gly Leu  Leu Ala Ala Met Gln  Gly Ala Ile Lys Ile  Ser Glu Asn 
    2240                 2245                 2250             


Pro Ala  Leu Asp Leu Pro Ser  Gln Gly Tyr Lys Arg  Glu Val Ser 
    2255                 2260                 2265             


Thr Glu  Asp Asp Glu Glu Glu  Glu Glu Ile Val His  Met Gly Asn 
    2270                 2275                 2280             


Ala Ile  Met Ser Phe Tyr Ser  Ala Leu Ile Asp Leu  Leu Gly Arg 
    2285                 2290                 2295             


Cys Ala  Pro Glu Met His Leu  Ile Gln Thr Gly Lys  Gly Glu Ala 
    2300                 2305                 2310             


Ile Arg  Ile Arg Ser Ile Leu  Arg Ser Leu Val Pro  Thr Glu Asp 
    2315                 2320                 2325             


Leu Val  Gly Ile Ile Ser Ile  Pro Leu Lys Leu Pro  Ser Leu Asn 
    2330                 2335                 2340             


Lys Asp  Gly Ser Val Ser Glu  Pro Asp Met Ala Ala  Asn Phe Cys 
    2345                 2350                 2355             


Pro Asp  His Lys Ala Pro Met  Val Leu Phe Leu Asp  Arg Val Tyr 
    2360                 2365                 2370             


Gly Ile  Lys Asp Gln Thr Phe  Leu Leu His Leu Leu  Glu Val Gly 
    2375                 2380                 2385             


Phe Leu  Pro Asp Leu Arg Ala  Ser Ala Ser Leu Asp  Thr Val Ser 
    2390                 2395                 2400             


Leu Ser  Thr Thr Glu Ala Ala  Leu Ala Leu Asn Arg  Tyr Ile Cys 
    2405                 2410                 2415             


Ser Ala  Val Leu Pro Leu Leu  Thr Arg Cys Ala Pro  Leu Phe Ala 
    2420                 2425                 2430             


Gly Thr  Glu His Cys Thr Ser  Leu Ile Asp Ser Thr  Leu Gln Thr 
    2435                 2440                 2445             


Ile Tyr  Arg Leu Ser Lys Gly  Arg Ser Leu Thr Lys  Ala Gln Arg 
    2450                 2455                 2460             


Asp Thr  Ile Glu Glu Cys Leu  Leu Ala Ile Cys Asn  His Leu Arg 
    2465                 2470                 2475             


Pro Ser  Met Leu Gln Gln Leu  Leu Arg Arg Leu Val  Phe Asp Val 
    2480                 2485                 2490             


Pro Gln  Leu Asn Glu Tyr Cys  Lys Met Pro Leu Lys  Leu Leu Thr 
    2495                 2500                 2505             


Asn His  Tyr Glu Gln Cys Trp  Lys Tyr Tyr Cys Leu  Pro Ser Gly 
    2510                 2515                 2520             


Trp Gly  Ser Tyr Gly Leu Ala  Val Glu Glu Glu Leu  His Leu Thr 
    2525                 2530                 2535             


Glu Lys  Leu Phe Trp Gly Ile  Phe Asp Ser Leu Ser  His Lys Lys 
    2540                 2545                 2550             


Tyr Asp  Pro Asp Leu Phe Arg  Met Ala Leu Pro Cys  Leu Ser Ala 
    2555                 2560                 2565             


Ile Ala  Gly Ala Leu Pro Pro  Asp Tyr Leu Asp Thr  Arg Ile Thr 
    2570                 2575                 2580             


Ala Thr  Leu Glu Lys Gln Ile  Ser Val Asp Ala Asp  Gly Asn Phe 
    2585                 2590                 2595             


Asp Pro  Lys Pro Ile Asn Thr  Met Asn Phe Ser Leu  Pro Glu Lys 
    2600                 2605                 2610             


Leu Glu  Tyr Ile Val Thr Lys  Tyr Ala Glu His Ser  His Asp Lys 
    2615                 2620                 2625             


Trp Ala  Cys Asp Lys Ser Gln  Ser Gly Trp Lys Tyr  Gly Ile Ser 
    2630                 2635                 2640             


Leu Asp  Glu Asn Val Lys Thr  His Pro Leu Ile Arg  Pro Phe Lys 
    2645                 2650                 2655             


Thr Leu  Thr Glu Lys Glu Lys  Glu Ile Tyr Arg Trp  Pro Ala Arg 
    2660                 2665                 2670             


Glu Ser  Leu Lys Thr Met Leu  Ala Val Gly Trp Thr  Val Glu Arg 
    2675                 2680                 2685             


Thr Lys  Glu Gly Glu Ala Leu  Val Gln Gln Arg Glu  Asn Glu Lys 
    2690                 2695                 2700             


Leu Arg  Ser Val Ser Gln Ala  Asn Gln Gly Asn Ser  Tyr Ser Pro 
    2705                 2710                 2715             


Ala Pro  Leu Asp Leu Ser Asn  Val Val Leu Ser Arg  Glu Leu Gln 
    2720                 2725                 2730             


Gly Met  Val Glu Val Val Ala  Glu Asn Tyr His Asn  Ile Trp Ala 
    2735                 2740                 2745             


Lys Lys  Lys Lys Leu Glu Leu  Glu Ser Lys Gly Gly  Gly Ser His 
    2750                 2755                 2760             


Pro Leu  Leu Val Pro Tyr Asp  Thr Leu Thr Ala Lys  Glu Lys Phe 
    2765                 2770                 2775             


Lys Asp  Arg Glu Lys Ala Gln  Asp Leu Phe Lys Phe  Leu Gln Val 
    2780                 2785                 2790             


Asn Gly  Ile Ile Val Ser Arg  Gly Met Lys Asp Met  Glu Leu Asp 
    2795                 2800                 2805             


Ala Ser  Ser Met Glu Lys Arg  Phe Ala Tyr Lys Phe  Leu Lys Lys 
    2810                 2815                 2820             


Ile Leu  Lys Tyr Val Asp Ser  Ala Gln Glu Phe Ile  Ala His Leu 
    2825                 2830                 2835             


Glu Ala  Ile Val Ser Ser Gly  Lys Thr Glu Lys Ser  Pro Arg Asp 
    2840                 2845                 2850             


Gln Glu  Ile Lys Phe Phe Ala  Lys Val Leu Leu Pro  Leu Val Asp 
    2855                 2860                 2865             


Gln Tyr  Phe Thr Ser His Cys  Leu Tyr Phe Leu Ser  Ser Pro Leu 
    2870                 2875                 2880             


Lys Pro  Leu Ser Ser Ser Gly  Tyr Ala Ser His Lys  Glu Lys Glu 
    2885                 2890                 2895             


Met Val  Ala Gly Leu Phe Cys  Lys Leu Ala Ala Leu  Val Arg His 
    2900                 2905                 2910             


Arg Ile  Ser Leu Phe Gly Ser  Asp Ser Thr Thr Met  Val Ser Cys 
    2915                 2920                 2925             


Leu His  Ile Leu Ala Gln Thr  Leu Asp Thr Arg Thr  Val Met Lys 
    2930                 2935                 2940             


Ser Gly  Ser Glu Leu Val Lys  Ala Gly Leu Arg Ala  Phe Phe Glu 
    2945                 2950                 2955             


Asn Ala  Ala Glu Asp Leu Glu  Lys Thr Ser Glu Asn  Leu Lys Leu 
    2960                 2965                 2970             


Gly Lys  Phe Thr His Ser Arg  Thr Gln Ile Lys Gly  Val Ser Gln 
    2975                 2980                 2985             


Asn Ile  Asn Tyr Thr Thr Val  Ala Leu Leu Pro Ile  Leu Thr Ser 
    2990                 2995                 3000             


Ile Phe  Glu His Val Thr Gln  His Gln Phe Gly Met  Asp Leu Leu 
    3005                 3010                 3015             


Leu Gly  Asp Val Gln Ile Ser  Cys Tyr His Ile Leu  Cys Ser Leu 
    3020                 3025                 3030             


Tyr Ser  Leu Gly Thr Gly Lys  Asn Ile Tyr Val Glu  Arg Gln Arg 
    3035                 3040                 3045             


Pro Ala  Leu Gly Glu Cys Leu  Ala Ser Leu Ala Ala  Ala Ile Pro 
    3050                 3055                 3060             


Val Ala  Phe Leu Glu Pro Thr  Leu Asn Arg Tyr Asn  Pro Leu Ser 
    3065                 3070                 3075             


Val Phe  Asn Thr Lys Thr Pro  Arg Glu Arg Ser Ile  Leu Gly Met 
    3080                 3085                 3090             


Pro Asp  Thr Val Glu Asp Met  Cys Pro Asp Ile Pro  Gln Leu Glu 
    3095                 3100                 3105             


Gly Leu  Met Lys Glu Ile Asn  Asp Leu Ala Glu Ser  Gly Ala Arg 
    3110                 3115                 3120             


Tyr Thr  Glu Met Pro His Val  Ile Glu Val Ile Leu  Pro Met Leu 
    3125                 3130                 3135             


Cys Asn  Tyr Leu Ser Tyr Trp  Trp Glu Arg Gly Pro  Glu Asn Leu 
    3140                 3145                 3150             


Pro Pro  Ser Thr Gly Pro Cys  Cys Thr Lys Val Thr  Ser Glu His 
    3155                 3160                 3165             


Leu Ser  Leu Ile Leu Gly Asn  Ile Leu Lys Ile Ile  Asn Asn Asn 
    3170                 3175                 3180             


Leu Gly  Ile Asp Glu Ala Ser  Trp Met Lys Arg Ile  Ala Val Tyr 
    3185                 3190                 3195             


Ala Gln  Pro Ile Ile Ser Lys  Ala Arg Pro Asp Leu  Leu Arg Ser 
    3200                 3205                 3210             


His Phe  Ile Pro Thr Leu Glu  Lys Leu Lys Lys Lys  Ala Val Lys 
    3215                 3220                 3225             


Thr Val  Gln Glu Glu Glu Gln  Leu Lys Ala Asp Gly  Lys Gly Asp 
    3230                 3235                 3240             


Thr Gln  Glu Ala Glu Leu Leu  Ile Leu Asp Glu Phe  Ala Val Leu 
    3245                 3250                 3255             


Cys Arg  Asp Leu Tyr Ala Phe  Tyr Pro Met Leu Ile  Arg Tyr Val 
    3260                 3265                 3270             


Asp Asn  Asn Arg Ser Asn Trp  Leu Lys Ser Pro Asp  Ala Asp Ser 
    3275                 3280                 3285             


Asp Gln  Leu Phe Arg Met Val  Ala Glu Val Phe Ile  Leu Trp Cys 
    3290                 3295                 3300             


Lys Ser  His Asn Phe Lys Arg  Glu Glu Gln Asn Phe  Val Ile Gln 
    3305                 3310                 3315             


Asn Glu  Ile Asn Asn Leu Ala  Phe Leu Thr Gly Asp  Ser Lys Ser 
    3320                 3325                 3330             


Lys Met  Ser Lys Ala Met Gln  Val Lys Ser Gly Gly  Gln Asp Gln 
    3335                 3340                 3345             


Glu Arg  Lys Lys Thr Lys Arg  Arg Gly Asp Leu Tyr  Ser Ile Gln 
    3350                 3355                 3360             


Thr Ser  Leu Ile Val Ala Ala  Leu Lys Lys Met Leu  Pro Ile Gly 
    3365                 3370                 3375             


Leu Asn  Met Cys Thr Pro Gly  Asp Gln Glu Leu Ile  Ser Leu Ala 
    3380                 3385                 3390             


Lys Ser  Arg Tyr Ser His Arg  Asp Thr Asp Glu Glu  Val Arg Glu 
    3395                 3400                 3405             


His Leu  Arg Asn Asn Leu His  Leu Gln Glu Lys Ser  Asp Asp Pro 
    3410                 3415                 3420             


Ala Val  Lys Trp Gln Leu Asn  Leu Tyr Lys Asp Val  Leu Lys Ser 
    3425                 3430                 3435             


Glu Glu  Pro Phe Asn Pro Glu  Lys Thr Val Glu Arg  Val Gln Arg 
    3440                 3445                 3450             


Ile Ser  Ala Ala Val Phe His  Leu Glu Gln Val Glu  Gln Pro Leu 
    3455                 3460                 3465             


Arg Ser  Lys Lys Ala Val Trp  His Lys Leu Leu Ser  Lys Gln Arg 
    3470                 3475                 3480             


Lys Arg  Ala Val Val Ala Cys  Phe Arg Met Ala Pro  Leu Tyr Asn 
    3485                 3490                 3495             


Leu Pro  Arg His Arg Ser Ile  Asn Leu Phe Leu His  Gly Tyr Gln 
    3500                 3505                 3510             


Arg Phe  Trp Ile Glu Thr Glu  Glu Tyr Ser Phe Glu  Glu Lys Leu 
    3515                 3520                 3525             


Val Gln  Asp Leu Ala Lys Ser  Pro Lys Val Glu Glu  Glu Glu Glu 
    3530                 3535                 3540             


Glu Glu  Thr Glu Lys Gln Pro  Asp Pro Leu His Gln  Ile Ile Leu 
    3545                 3550                 3555             


Tyr Phe  Ser Arg Asn Ala Leu  Thr Glu Arg Ser Lys  Leu Glu Asp 
    3560                 3565                 3570             


Asp Pro  Leu Tyr Thr Ser Tyr  Ser Ser Met Met Ala  Lys Ser Cys 
    3575                 3580                 3585             


Gln Ser  Gly Glu Asp Glu Glu  Glu Asp Glu Asp Lys  Glu Lys Thr 
    3590                 3595                 3600             


Phe Glu  Glu Lys Glu Met Glu  Lys Gln Lys Thr Leu  Tyr Gln Gln 
    3605                 3610                 3615             


Ala Arg  Leu His Glu Arg Gly  Ala Ala Glu Met Val  Leu Gln Met 
    3620                 3625                 3630             


Ile Ser  Ala Ser Lys Gly Glu  Met Ser Pro Met Val  Val Glu Thr 
    3635                 3640                 3645             


Leu Lys  Leu Gly Ile Ala Ile  Leu Asn Gly Gly Asn  Ala Gly Val 
    3650                 3655                 3660             


Gln Gln  Lys Met Leu Asp Tyr  Leu Lys Glu Lys Lys  Asp Ala Gly 
    3665                 3670                 3675             


Phe Phe  Gln Ser Leu Ser Gly  Leu Met Gln Ser Cys  Ser Val Leu 
    3680                 3685                 3690             


Asp Leu  Asn Ala Phe Glu Arg  Gln Asn Lys Ala Glu  Gly Leu Gly 
    3695                 3700                 3705             


Met Val  Thr Glu Glu Gly Thr  Leu Ile Val Arg Glu  Arg Gly Glu 
    3710                 3715                 3720             


Lys Val  Leu Gln Asn Asp Glu  Phe Thr Arg Asp Leu  Phe Arg Phe 
    3725                 3730                 3735             


Leu Gln  Leu Leu Cys Glu Gly  His Asn Ser Asp Phe  Gln Asn Phe 
    3740                 3745                 3750             


Leu Arg  Thr Gln Met Gly Asn  Thr Thr Thr Val Asn  Val Ile Ile 
    3755                 3760                 3765             


Ser Thr  Val Asp Tyr Leu Leu  Arg Leu Gln Glu Ser  Ile Ser Asp 
    3770                 3775                 3780             


Phe Tyr  Trp Tyr Tyr Ser Gly  Lys Asp Ile Ile Asp  Glu Ser Gly 
    3785                 3790                 3795             


Gln His  Asn Phe Ser Lys Ala  Leu Ala Val Thr Lys  Gln Ile Phe 
    3800                 3805                 3810             


Asn Ser  Leu Thr Glu Tyr Ile  Gln Gly Pro Cys Ile  Gly Asn Gln 
    3815                 3820                 3825             


Gln Ser  Leu Ala His Ser Arg  Leu Trp Asp Ala Val  Val Gly Phe 
    3830                 3835                 3840             


Leu His  Val Phe Ala Asn Met  Gln Met Lys Leu Ser  Gln Asp Ser 
    3845                 3850                 3855             


Ser Gln  Ile Glu Leu Leu Lys  Glu Leu Leu Asp Leu  Leu Gln Asp 
    3860                 3865                 3870             


Met Val  Val Met Leu Leu Ser  Leu Leu Glu Gly Asn  Val Val Asn 
    3875                 3880                 3885             


Gly Thr  Ile Gly Lys Gln Met  Val Asp Thr Leu Val  Glu Ser Ser 
    3890                 3895                 3900             


Thr Asn  Val Glu Met Ile Leu  Lys Phe Phe Asp Met  Phe Leu Lys 
    3905                 3910                 3915             


Leu Lys  Asp Leu Thr Ser Ser  Asp Thr Phe Lys Glu  Tyr Asp Pro 
    3920                 3925                 3930             


Asp Gly  Lys Gly Ile Ile Ser  Lys Lys Glu Phe Gln  Lys Ala Met 
    3935                 3940                 3945             


Glu Gly  Gln Lys Gln Tyr Thr  Gln Ser Glu Ile Asp  Phe Leu Leu 
    3950                 3955                 3960             


Ser Cys  Ala Glu Ala Asp Glu  Asn Asp Met Phe Asn  Tyr Val Asp 
    3965                 3970                 3975             


Phe Val  Asp Arg Phe His Glu  Pro Ala Lys Asp Ile  Gly Phe Asn 
    3980                 3985                 3990             


Val Ala  Val Leu Leu Thr Asn  Leu Ser Glu His Met  Pro Asn Asp 
    3995                 4000                 4005             


Ser Arg  Leu Lys Cys Leu Leu  Asp Pro Ala Glu Ser  Val Leu Asn 
    4010                 4015                 4020             


Tyr Phe  Glu Pro Tyr Leu Gly  Arg Ile Glu Ile Met  Gly Gly Ala 
    4025                 4030                 4035             


Lys Lys  Ile Glu Arg Val Tyr  Phe Glu Ile Ser Glu  Ser Ser Arg 
    4040                 4045                 4050             


Thr Gln  Trp Glu Lys Pro Gln  Val Lys Glu Ser Lys  Arg Gln Phe 
    4055                 4060                 4065             


Ile Phe  Asp Val Val Asn Glu  Gly Gly Glu Gln Glu  Lys Met Glu 
    4070                 4075                 4080             


Leu Phe  Val Asn Phe Cys Glu  Asp Thr Ile Phe Glu  Met Gln Leu 
    4085                 4090                 4095             


Ala Ser  Gln Ile Ser Glu Ser  Asp Ser Ala Asp Arg  Pro Glu Glu 
    4100                 4105                 4110             


Glu Glu  Glu Asp Glu Asp Ser  Ser Tyr Val Leu Glu  Ile Ala Gly 
    4115                 4120                 4125             


Glu Glu  Glu Glu Asp Gly Ser  Leu Glu Pro Ala Ser  Ala Phe Ala 
    4130                 4135                 4140             


Met Ala  Cys Ala Ser Val Lys  Arg Asn Val Thr Asp  Phe Leu Lys 
    4145                 4150                 4155             


Arg Ala  Thr Leu Lys Asn Leu  Arg Lys Gln Tyr Arg  Asn Val Lys 
    4160                 4165                 4170             


Lys Met  Thr Ala Lys Glu Leu  Val Lys Val Leu Phe  Ser Phe Phe 
    4175                 4180                 4185             


Trp Met  Leu Phe Val Gly Leu  Phe Gln Leu Leu Phe  Thr Ile Leu 
    4190                 4195                 4200             


Gly Gly  Ile Phe Gln Ile Leu  Trp Ser Thr Val Phe  Gly Gly Gly 
    4205                 4210                 4215             


Leu Val  Glu Gly Ala Lys Asn  Ile Arg Val Thr Lys  Ile Leu Gly 
    4220                 4225                 4230             


Asp Met  Pro Asp Pro Thr Gln  Phe Gly Ile His Asp  Asp Thr Met 
    4235                 4240                 4245             


Glu Ala  Glu Arg Ala Glu Val  Met Glu Pro Gly Ile  Thr Thr Glu 
    4250                 4255                 4260             


Leu Val  His Phe Ile Lys Gly  Glu Lys Gly Asp Thr  Asp Ile Met 
    4265                 4270                 4275             


Ser Asp  Leu Phe Gly Leu His  Pro Lys Lys Glu Gly  Ser Leu Lys 
    4280                 4285                 4290             


His Gly  Pro Glu Val Gly Leu  Gly Asp Leu Ser Glu  Ile Ile Gly 
    4295                 4300                 4305             


Lys Asp  Glu Pro Pro Thr Leu  Glu Ser Thr Val Gln  Lys Lys Arg 
    4310                 4315                 4320             


Lys Ala  Gln Ala Ala Glu Met  Lys Ala Ala Asn Glu  Ala Glu Gly 
    4325                 4330                 4335             


Lys Val  Glu Ser Glu Lys Ala  Asp Met Glu Asp Gly  Glu Lys Glu 
    4340                 4345                 4350             


Asp Lys  Asp Lys Glu Glu Glu  Gln Ala Glu Tyr Leu  Trp Thr Glu 
    4355                 4360                 4365             


Val Thr  Lys Lys Lys Lys Arg  Arg Cys Gly Gln Lys  Val Glu Lys 
    4370                 4375                 4380             


Pro Glu  Ala Phe Thr Ala Asn  Phe Phe Lys Gly Leu  Glu Ile Tyr 
    4385                 4390                 4395             


Gln Thr  Lys Leu Leu His Tyr  Leu Ala Arg Asn Phe  Tyr Asn Leu 
    4400                 4405                 4410             


Arg Phe  Leu Ala Leu Phe Val  Ala Phe Ala Ile Asn  Phe Ile Leu 
    4415                 4420                 4425             


Leu Phe  Tyr Lys Val Thr Glu  Glu Pro Leu Glu Glu  Glu Thr Glu 
    4430                 4435                 4440             


Asp Val  Ala Asn Leu Trp Asn  Ser Phe Asn Asp Glu  Glu Glu Glu 
    4445                 4450                 4455             


Glu Ala  Met Val Phe Phe Val  Leu Gln Glu Ser Thr  Gly Tyr Met 
    4460                 4465                 4470             


Ala Pro  Thr Leu Arg Ala Leu  Ala Ile Ile His Thr  Ile Ile Ser 
    4475                 4480                 4485             


Leu Val  Cys Val Val Gly Tyr  Tyr Cys Leu Lys Val  Pro Leu Val 
    4490                 4495                 4500             


Val Phe  Lys Arg Glu Lys Glu  Ile Ala Arg Lys Leu  Glu Phe Asp 
    4505                 4510                 4515             


Gly Leu  Tyr Ile Thr Glu Gln  Pro Ser Glu Asp Asp  Ile Lys Gly 
    4520                 4525                 4530             


Gln Trp  Asp Arg Leu Val Ile  Asn Thr Pro Ser Phe  Pro Asn Asn 
    4535                 4540                 4545             


Tyr Trp  Asp Lys Phe Val Lys  Arg Lys Val Ile Asn  Lys Tyr Gly 
    4550                 4555                 4560             


Asp Leu  Tyr Gly Ala Glu Arg  Ile Ala Glu Leu Leu  Gly Leu Asp 
    4565                 4570                 4575             


Lys Asn  Ala Leu Asp Phe Ser  Pro Val Glu Glu Thr  Lys Ala Glu 
    4580                 4585                 4590             


Ala Ala  Ser Leu Val Ser Trp  Leu Ser Ser Ile Asp  Met Lys Tyr 
    4595                 4600                 4605             


His Ile  Trp Lys Leu Gly Val  Val Phe Thr Asp Asn  Ser Phe Leu 
    4610                 4615                 4620             


Tyr Leu  Ala Trp Tyr Thr Thr  Met Ser Val Leu Gly  His Tyr Asn 
    4625                 4630                 4635             


Asn Phe  Phe Phe Ala Ala His  Leu Leu Asp Ile Ala  Met Gly Phe 
    4640                 4645                 4650             


Lys Thr  Leu Arg Thr Ile Leu  Ser Ser Val Thr His  Asn Gly Lys 
    4655                 4660                 4665             


Gln Leu  Val Leu Thr Val Gly  Leu Leu Ala Val Val  Val Tyr Leu 
    4670                 4675                 4680             


Tyr Thr  Val Val Ala Phe Asn  Phe Phe Arg Lys Phe  Tyr Asn Lys 
    4685                 4690                 4695             


Ser Glu  Asp Asp Asp Glu Pro  Asp Met Lys Cys Asp  Asp Met Met 
    4700                 4705                 4710             


Thr Cys  Tyr Leu Phe His Met  Tyr Val Gly Val Arg  Ala Gly Gly 
    4715                 4720                 4725             


Gly Ile  Gly Asp Glu Ile Glu  Asp Pro Ala Gly Asp  Pro Tyr Glu 
    4730                 4735                 4740             


Met Tyr  Arg Ile Val Phe Asp  Ile Thr Phe Phe Phe  Phe Val Ile 
    4745                 4750                 4755             


Val Ile  Leu Leu Ala Ile Ile  Gln Gly Leu Ile Ile  Asp Ala Phe 
    4760                 4765                 4770             


Gly Glu  Leu Arg Asp Gln Gln  Glu Gln Val Arg Glu  Asp Met Glu 
    4775                 4780                 4785             


Thr Lys  Cys Phe Ile Cys Gly  Ile Gly Asn Asp Tyr  Phe Asp Thr 
    4790                 4795                 4800             


Thr Pro  His Gly Phe Glu Thr  His Thr Leu Gln Glu  His Asn Leu 
    4805                 4810                 4815             


Ala Asn  Tyr Leu Phe Phe Leu  Met Tyr Leu Ile Asn  Lys Asp Glu 
    4820                 4825                 4830             


Thr Glu  His Thr Gly Gln Glu  Ser Tyr Val Trp Lys  Met Tyr Gln 
    4835                 4840                 4845             


Glu Arg  Cys Trp Asp Phe Phe  Pro Ala Gly Asp Cys  Phe Arg Lys 
    4850                 4855                 4860             


Gln Tyr  Glu Asp Gln Leu Gly  
    4865                 4870 


<210>  213
<211>  715
<212>  PRT
<213>  homo sapiens

<400>  213

Met Val Gln Lys Tyr Gln Ser Pro Val Arg Val Tyr Lys Tyr Pro Phe 
1               5                   10                  15      


Glu Leu Ile Met Ala Ala Tyr Glu Arg Arg Phe Pro Thr Cys Pro Leu 
            20                  25                  30          


Ile Pro Met Phe Val Gly Ser Asp Thr Val Ser Glu Phe Lys Ser Glu 
        35                  40                  45              


Asp Gly Ala Ile His Val Ile Glu Arg Arg Cys Lys Leu Asp Val Asp 
    50                  55                  60                  


Ala Pro Arg Leu Leu Lys Lys Ile Ala Gly Val Asp Tyr Val Tyr Phe 
65                  70                  75                  80  


Val Gln Lys Asn Ser Leu Asn Ser Arg Glu Arg Thr Leu His Ile Glu 
                85                  90                  95      


Ala Tyr Asn Glu Thr Phe Ser Asn Arg Val Ile Ile Asn Glu His Cys 
            100                 105                 110         


Cys Tyr Thr Val His Pro Glu Asn Glu Asp Trp Thr Cys Phe Glu Gln 
        115                 120                 125             


Ser Ala Ser Leu Asp Ile Lys Ser Phe Phe Gly Phe Glu Ser Thr Val 
    130                 135                 140                 


Glu Lys Ile Ala Met Lys Gln Tyr Thr Ser Asn Ile Lys Lys Gly Lys 
145                 150                 155                 160 


Glu Ile Ile Glu Tyr Tyr Leu Arg Gln Leu Glu Glu Glu Gly Ile Thr 
                165                 170                 175     


Phe Val Pro Arg Trp Ser Pro Pro Ser Ile Thr Pro Ser Ser Glu Thr 
            180                 185                 190         


Ser Ser Ser Ser Ser Lys Lys Gln Ala Ala Ser Met Ala Val Val Ile 
        195                 200                 205             


Pro Glu Ala Ala Leu Lys Glu Gly Leu Ser Gly Asp Ala Leu Ser Ser 
    210                 215                 220                 


Pro Ser Ala Pro Glu Pro Val Val Gly Thr Pro Asp Asp Lys Leu Asp 
225                 230                 235                 240 


Ala Asp His Ile Lys Arg Tyr Leu Gly Asp Leu Thr Pro Leu Gln Glu 
                245                 250                 255     


Ser Cys Leu Ile Arg Leu Arg Gln Trp Leu Gln Glu Thr His Lys Gly 
            260                 265                 270         


Lys Ile Pro Lys Asp Glu His Ile Leu Arg Phe Leu Arg Ala Arg Asp 
        275                 280                 285             


Phe Asn Ile Asp Lys Ala Arg Glu Ile Met Cys Gln Ser Leu Thr Trp 
    290                 295                 300                 


Arg Lys Gln His Gln Val Asp Tyr Ile Leu Glu Thr Trp Thr Pro Pro 
305                 310                 315                 320 


Gln Val Leu Gln Asp Tyr Tyr Ala Gly Gly Trp His His His Asp Lys 
                325                 330                 335     


Asp Gly Arg Pro Leu Tyr Val Leu Arg Leu Gly Gln Met Asp Thr Lys 
            340                 345                 350         


Gly Leu Val Arg Ala Leu Gly Glu Glu Ala Leu Leu Arg Tyr Val Leu 
        355                 360                 365             


Ser Val Asn Glu Glu Arg Leu Arg Arg Cys Glu Glu Asn Thr Lys Val 
    370                 375                 380                 


Phe Gly Arg Pro Ile Ser Ser Trp Thr Cys Leu Val Asp Leu Glu Gly 
385                 390                 395                 400 


Leu Asn Met Arg His Leu Trp Arg Pro Gly Val Lys Ala Leu Leu Arg 
                405                 410                 415     


Ile Ile Glu Val Val Glu Ala Asn Tyr Pro Glu Thr Leu Gly Arg Leu 
            420                 425                 430         


Leu Ile Leu Arg Ala Pro Arg Val Phe Pro Val Leu Trp Thr Leu Val 
        435                 440                 445             


Ser Pro Phe Ile Asp Asp Asn Thr Arg Arg Lys Phe Leu Ile Tyr Ala 
    450                 455                 460                 


Gly Asn Asp Tyr Gln Gly Pro Gly Gly Leu Leu Asp Tyr Ile Asp Lys 
465                 470                 475                 480 


Glu Ile Ile Pro Asp Phe Leu Ser Gly Glu Cys Met Cys Glu Val Pro 
                485                 490                 495     


Glu Gly Gly Leu Val Pro Lys Ser Leu Tyr Arg Thr Ala Glu Glu Leu 
            500                 505                 510         


Glu Asn Glu Asp Leu Lys Leu Trp Thr Glu Thr Ile Tyr Gln Ser Ala 
        515                 520                 525             


Ser Val Phe Lys Gly Ala Pro His Glu Ile Leu Ile Gln Ile Val Asp 
    530                 535                 540                 


Ala Ser Ser Val Ile Thr Trp Asp Phe Asp Val Cys Lys Gly Asp Ile 
545                 550                 555                 560 


Val Phe Asn Ile Tyr His Ser Lys Arg Ser Pro Gln Pro Pro Lys Lys 
                565                 570                 575     


Asp Ser Leu Gly Ala His Ser Ile Thr Ser Pro Gly Gly Asn Asn Val 
            580                 585                 590         


Gln Leu Ile Asp Lys Val Trp Gln Leu Gly Arg Asp Tyr Ser Met Val 
        595                 600                 605             


Glu Ser Pro Leu Ile Cys Lys Glu Gly Glu Ser Val Gln Gly Ser His 
    610                 615                 620                 


Val Thr Arg Trp Pro Gly Phe Tyr Ile Leu Gln Trp Lys Phe His Ser 
625                 630                 635                 640 


Met Pro Ala Cys Ala Ala Ser Ser Leu Pro Arg Val Asp Asp Val Leu 
                645                 650                 655     


Ala Ser Leu Gln Val Ser Ser His Lys Cys Lys Val Met Tyr Tyr Thr 
            660                 665                 670         


Glu Val Ile Gly Ser Glu Asp Phe Arg Gly Ser Met Thr Ser Leu Glu 
        675                 680                 685             


Ser Ser His Ser Gly Phe Ser Gln Leu Ser Ala Ala Thr Thr Ser Ser 
    690                 695                 700                 


Ser Gln Ser His Ser Ser Ser Met Ile Ser Arg 
705                 710                 715 


<210>  214
<211>  175
<212>  PRT
<213>  homo sapiens

<400>  214

Met Glu Lys Ile Pro Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser 
1               5                   10                  15      


Tyr Thr Leu Ala Arg Asp Thr Thr Val Lys Pro Gly Ala Lys Lys Asp 
            20                  25                  30          


Thr Lys Asp Ser Arg Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Thr Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Met Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly Arg 
    130                 135                 140                 


Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ala Asp Thr Ala Leu Leu 
145                 150                 155                 160 


Leu Asp Asn Met Lys Lys Ala Leu Lys Leu Leu Lys Thr Glu Leu 
                165                 170                 175 


<210>  215
<211>  961
<212>  PRT
<213>  homo sapiens

<400>  215

Met Glu Val Pro Ala Ala Gly Arg Val Pro Ala Glu Gly Ala Pro Thr 
1               5                   10                  15      


Ala Ala Val Ala Glu Val Arg Cys Pro Gly Pro Ala Pro Leu Arg Leu 
            20                  25                  30          


Leu Glu Trp Arg Val Ala Ala Gly Ala Ala Val Arg Ile Gly Ser Val 
        35                  40                  45              


Leu Ala Val Phe Glu Ala Ala Ala Ser Ala Gln Ser Ala Gly Ala Ser 
    50                  55                  60                  


Gln Ser Arg Val Ala Ser Gly Gly Cys Val Arg Pro Ala Arg Pro Glu 
65                  70                  75                  80  


Arg Arg Leu Arg Ser Glu Arg Ala Gly Val Val Arg Glu Leu Cys Ala 
                85                  90                  95      


Gln Pro Gly Gln Val Val Ala Pro Gly Ala Val Leu Val Arg Leu Glu 
            100                 105                 110         


Gly Cys Ser His Pro Val Val Met Lys Gly Leu Cys Ala Glu Cys Gly 
        115                 120                 125             


Gln Asp Leu Thr Gln Leu Gln Ser Lys Asn Gly Lys Gln Gln Val Pro 
    130                 135                 140                 


Leu Ser Thr Ala Thr Val Ser Met Val His Ser Val Pro Glu Leu Met 
145                 150                 155                 160 


Val Ser Ser Glu Gln Ala Glu Gln Leu Gly Arg Glu Asp Gln Gln Arg 
                165                 170                 175     


Leu His Arg Asn Arg Lys Leu Val Leu Met Val Asp Leu Asp Gln Thr 
            180                 185                 190         


Leu Ile His Thr Thr Glu Gln His Cys Gln Gln Met Ser Asn Lys Gly 
        195                 200                 205             


Ile Phe His Phe Gln Leu Gly Arg Gly Glu Pro Met Leu His Thr Arg 
    210                 215                 220                 


Leu Arg Pro His Cys Lys Asp Phe Leu Glu Lys Ile Ala Lys Leu Tyr 
225                 230                 235                 240 


Glu Leu His Val Phe Thr Phe Gly Ser Arg Leu Tyr Ala His Thr Ile 
                245                 250                 255     


Ala Gly Phe Leu Asp Pro Glu Lys Lys Leu Phe Ser His Arg Ile Leu 
            260                 265                 270         


Ser Arg Asp Glu Cys Ile Asp Pro Phe Ser Lys Thr Gly Asn Leu Arg 
        275                 280                 285             


Asn Leu Phe Pro Cys Gly Asp Ser Met Val Cys Ile Ile Asp Asp Arg 
    290                 295                 300                 


Glu Asp Val Trp Lys Phe Ala Pro Asn Leu Ile Thr Val Lys Lys Tyr 
305                 310                 315                 320 


Val Tyr Phe Gln Gly Thr Gly Asp Met Asn Ala Pro Pro Gly Ser Arg 
                325                 330                 335     


Glu Ser Gln Thr Arg Lys Lys Val Asn His Ser Arg Gly Thr Glu Val 
            340                 345                 350         


Ser Glu Pro Ser Pro Pro Val Arg Asp Pro Glu Gly Val Thr Gln Ala 
        355                 360                 365             


Pro Gly Val Glu Pro Ser Asn Gly Leu Glu Lys Pro Ala Arg Glu Leu 
    370                 375                 380                 


Asn Gly Ser Glu Ala Ala Thr Pro Arg Asp Ser Pro Arg Pro Gly Lys 
385                 390                 395                 400 


Pro Asp Glu Arg Asp Ile Trp Pro Pro Ala Gln Ala Pro Thr Ser Ser 
                405                 410                 415     


Gln Glu Leu Ala Gly Ala Pro Glu Pro Gln Gly Ser Cys Ala Gln Gly 
            420                 425                 430         


Gly Arg Val Ala Pro Gly Gln Arg Pro Ala Gln Gly Ala Thr Gly Thr 
        435                 440                 445             


Asp Leu Asp Phe Asp Leu Ser Ser Asp Ser Glu Ser Ser Ser Glu Ser 
    450                 455                 460                 


Glu Gly Thr Lys Ser Ser Ser Ser Ala Ser Asp Gly Glu Ser Glu Gly 
465                 470                 475                 480 


Lys Arg Gly Arg Gln Lys Pro Lys Ala Ala Pro Glu Gly Ala Gly Ala 
                485                 490                 495     


Leu Ala Gln Gly Ser Ser Leu Glu Pro Gly Arg Pro Ala Ala Pro Ser 
            500                 505                 510         


Leu Pro Gly Glu Ala Glu Pro Gly Ala His Ala Pro Asp Lys Glu Pro 
        515                 520                 525             


Glu Leu Gly Gly Gln Glu Glu Gly Glu Arg Asp Gly Leu Cys Gly Leu 
    530                 535                 540                 


Gly Asn Gly Cys Ala Asp Arg Lys Glu Ala Glu Thr Glu Ser Gln Asn 
545                 550                 555                 560 


Ser Glu Leu Ser Gly Val Thr Ala Gly Glu Ser Leu Asp Gln Ser Met 
                565                 570                 575     


Glu Glu Glu Glu Glu Glu Asp Thr Asp Glu Asp Asp His Leu Ile Tyr 
            580                 585                 590         


Leu Glu Glu Ile Leu Val Arg Val His Thr Asp Tyr Tyr Ala Lys Tyr 
        595                 600                 605             


Asp Arg Tyr Leu Asn Lys Glu Ile Glu Glu Ala Pro Asp Ile Arg Lys 
    610                 615                 620                 


Ile Val Pro Glu Leu Lys Ser Lys Val Leu Ala Asp Val Ala Ile Ile 
625                 630                 635                 640 


Phe Ser Gly Leu His Pro Thr Asn Phe Pro Ile Glu Lys Thr Arg Glu 
                645                 650                 655     


His Tyr His Ala Thr Ala Leu Gly Ala Lys Ile Leu Thr Arg Leu Val 
            660                 665                 670         


Leu Ser Pro Asp Ala Pro Asp Arg Ala Thr His Leu Ile Ala Ala Arg 
        675                 680                 685             


Ala Gly Thr Glu Lys Val Leu Gln Ala Gln Glu Cys Gly His Leu His 
    690                 695                 700                 


Val Val Asn Pro Asp Trp Leu Trp Ser Cys Leu Glu Arg Trp Asp Lys 
705                 710                 715                 720 


Val Glu Glu Gln Leu Phe Pro Leu Arg Asp Asp His Thr Lys Ala Gln 
                725                 730                 735     


Arg Glu Asn Ser Pro Ala Ala Phe Pro Asp Arg Glu Gly Val Pro Pro 
            740                 745                 750         


Thr Ala Leu Phe His Pro Met Pro Val Leu Pro Lys Ala Gln Pro Gly 
        755                 760                 765             


Pro Glu Val Arg Ile Tyr Asp Ser Asn Thr Gly Lys Leu Ile Arg Thr 
    770                 775                 780                 


Gly Ala Arg Gly Pro Pro Ala Pro Ser Ser Ser Leu Pro Ile Arg Gln 
785                 790                 795                 800 


Glu Pro Ser Ser Phe Arg Ala Val Pro Pro Pro Gln Pro Gln Met Phe 
                805                 810                 815     


Gly Glu Glu Leu Pro Asp Ala Gln Asp Gly Glu Gln Pro Gly Pro Ser 
            820                 825                 830         


Arg Arg Lys Arg Gln Pro Ser Met Ser Glu Thr Met Pro Leu Tyr Thr 
        835                 840                 845             


Leu Cys Lys Glu Asp Leu Glu Ser Met Asp Lys Glu Val Asp Asp Ile 
    850                 855                 860                 


Leu Gly Glu Gly Ser Asp Asp Ser Asp Ser Glu Lys Arg Arg Pro Glu 
865                 870                 875                 880 


Glu Gln Glu Glu Glu Pro Gln Pro Arg Lys Pro Gly Thr Arg Arg Gly 
                885                 890                 895     


Ala Asp Ala Arg Ala Pro Ala Ser Ser Glu Arg Ser Ala Ala Gly Gly 
            900                 905                 910         


Arg Gly Pro Arg Gly His Lys Arg Lys Leu Asn Glu Glu Asp Ala Ala 
        915                 920                 925             


Ser Glu Ser Ser Arg Glu Ser Ser Asn Glu Asp Glu Gly Ser Ser Ser 
    930                 935                 940                 


Glu Ala Asp Glu Met Ala Lys Ala Leu Glu Ala Glu Leu Asn Asp Leu 
945                 950                 955                 960 


Met 
    


<210>  216
<211>  653
<212>  PRT
<213>  homo sapiens

<400>  216

Met Gly Cys Ser Ser Ser Ser Thr Lys Thr Arg Arg Ser Asp Thr Ser 
1               5                   10                  15      


Leu Arg Ala Ala Leu Ile Ile Gln Asn Trp Tyr Arg Gly Tyr Lys Ala 
            20                  25                  30          


Arg Leu Lys Ala Arg Gln His Tyr Ala Leu Thr Ile Phe Gln Ser Ile 
        35                  40                  45              


Glu Tyr Ala Asp Glu Gln Gly Gln Met Gln Leu Ser Thr Phe Phe Ser 
    50                  55                  60                  


Phe Met Leu Glu Asn Tyr Thr His Ile His Lys Glu Glu Leu Glu Leu 
65                  70                  75                  80  


Arg Asn Gln Ser Leu Glu Ser Glu Gln Asp Met Arg Asp Arg Trp Asp 
                85                  90                  95      


Tyr Val Asp Ser Ile Asp Val Pro Asp Ser Tyr Asn Gly Pro Arg Leu 
            100                 105                 110         


Gln Phe Pro Leu Thr Cys Thr Asp Ile Asp Leu Leu Leu Glu Ala Phe 
        115                 120                 125             


Lys Glu Gln Gln Ile Leu His Ala His Tyr Val Leu Glu Val Leu Phe 
    130                 135                 140                 


Glu Thr Lys Lys Val Leu Lys Gln Met Pro Asn Phe Thr His Ile Gln 
145                 150                 155                 160 


Thr Ser Pro Ser Lys Glu Val Thr Ile Cys Gly Asp Leu His Gly Lys 
                165                 170                 175     


Leu Asp Asp Leu Phe Leu Ile Phe Tyr Lys Asn Gly Leu Pro Ser Glu 
            180                 185                 190         


Arg Asn Pro Tyr Val Phe Asn Gly Asp Phe Val Asp Arg Gly Lys Asn 
        195                 200                 205             


Ser Ile Glu Ile Leu Met Ile Leu Cys Val Ser Phe Leu Val Tyr Pro 
    210                 215                 220                 


Asn Asp Leu His Leu Asn Arg Gly Asn His Glu Asp Phe Met Met Asn 
225                 230                 235                 240 


Leu Arg Tyr Gly Phe Thr Lys Glu Ile Leu His Lys Tyr Lys Leu His 
                245                 250                 255     


Gly Lys Arg Ile Leu Gln Ile Leu Glu Glu Phe Tyr Ala Trp Leu Pro 
            260                 265                 270         


Ile Gly Thr Ile Val Asp Asn Glu Ile Leu Val Ile His Gly Gly Ile 
        275                 280                 285             


Ser Glu Thr Thr Asp Leu Asn Leu Leu His Arg Val Glu Arg Asn Lys 
    290                 295                 300                 


Met Lys Ser Val Leu Ile Pro Pro Thr Glu Thr Asn Arg Asp His Asp 
305                 310                 315                 320 


Thr Asp Ser Lys His Asn Lys Val Gly Val Thr Phe Asn Ala His Gly 
                325                 330                 335     


Arg Ile Lys Thr Asn Gly Ser Pro Thr Glu His Leu Thr Glu His Glu 
            340                 345                 350         


Trp Glu Gln Ile Ile Asp Ile Leu Trp Ser Asp Pro Arg Gly Lys Asn 
        355                 360                 365             


Gly Cys Phe Pro Asn Thr Cys Arg Gly Gly Gly Cys Tyr Phe Gly Pro 
    370                 375                 380                 


Asp Val Thr Ser Lys Ile Leu Asn Lys Tyr Gln Leu Lys Met Leu Ile 
385                 390                 395                 400 


Arg Ser His Glu Cys Lys Pro Glu Gly Tyr Glu Ile Cys His Asp Gly 
                405                 410                 415     


Lys Val Val Thr Ile Phe Ser Ala Ser Asn Tyr Tyr Glu Glu Gly Ser 
            420                 425                 430         


Asn Arg Gly Ala Tyr Ile Lys Leu Cys Ser Gly Thr Thr Pro Arg Phe 
        435                 440                 445             


Phe Gln Tyr Gln Val Thr Lys Ala Thr Cys Phe Gln Pro Leu Arg Gln 
    450                 455                 460                 


Arg Val Asp Thr Met Glu Asn Ser Ala Ile Lys Ile Leu Arg Glu Arg 
465                 470                 475                 480 


Val Ile Ser Arg Lys Ser Asp Leu Thr Arg Ala Phe Gln Leu Gln Asp 
                485                 490                 495     


His Arg Lys Ser Gly Lys Leu Ser Val Ser Gln Trp Ala Phe Cys Met 
            500                 505                 510         


Glu Asn Ile Leu Gly Leu Asn Leu Pro Trp Arg Ser Leu Ser Ser Asn 
        515                 520                 525             


Leu Val Asn Ile Asp Gln Asn Gly Asn Val Glu Tyr Met Ser Ser Phe 
    530                 535                 540                 


Gln Asn Ile Arg Ile Glu Lys Pro Val Gln Glu Ala His Ser Thr Leu 
545                 550                 555                 560 


Val Glu Thr Leu Tyr Arg Tyr Arg Ser Asp Leu Glu Ile Ile Phe Asn 
                565                 570                 575     


Ala Ile Asp Thr Asp His Ser Gly Leu Ile Ser Val Glu Glu Phe Arg 
            580                 585                 590         


Ala Met Trp Lys Leu Phe Ser Ser His Tyr Asn Val His Ile Asp Asp 
        595                 600                 605             


Ser Gln Val Asn Lys Leu Ala Asn Ile Met Asp Leu Asn Lys Asp Gly 
    610                 615                 620                 


Ser Ile Asp Phe Asn Glu Phe Leu Lys Ala Phe Tyr Val Val His Arg 
625                 630                 635                 640 


Tyr Glu Asp Leu Met Lys Pro Asp Val Thr Asn Leu Gly 
                645                 650             


<210>  217
<211>  3056
<212>  PRT
<213>  homo sapiens

<400>  217

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Thr Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Thr Lys Gly Cys Cys Ser Gln Thr Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Thr Ile Phe Leu 
225                 230                 235                 240 


Lys Thr Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Thr Leu Leu Tyr Ile Trp Thr Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Thr Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Thr Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Thr Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Thr Thr Thr Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Thr Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Thr Pro Tyr Val Leu Arg Cys Leu Thr Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Thr Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Thr 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Thr Leu 
    530                 535                 540                 


Ala Leu Thr Thr Ser Ile Val Pro Gly Ala Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Thr Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Thr Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Thr Thr 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Thr Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Thr Asn Ser Glu Thr Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Asn Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Thr Leu Phe Lys Asn Lys Thr Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Thr 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Thr Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Thr Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Thr Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Thr Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Thr Thr Ala Gln 
            900                 905                 910         


Thr Asn Thr Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Thr Leu Glu Pro Thr Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Thr Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Thr Arg Asp Ala Gln  Gly Gln Phe Leu Thr  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Thr Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Thr Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Thr  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Thr  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Thr Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Thr 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Thr Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Thr  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Thr Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Thr Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Thr Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Thr Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Thr Ala  Thr Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Thr  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Thr Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro Pro His  Phe Pro Ser 
    1370                 1375                 1380             


His Val  Ile Lys Ala Thr Phe  Ala Tyr Ile Ser Asn  Cys His Lys 
    1385                 1390                 1395             


Thr Lys  Leu Lys Ser Ile Leu  Glu Ile Leu Ser Lys  Ser Pro Asp 
    1400                 1405                 1410             


Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys Glu Gln  Ala Ala Glu 
    1415                 1420                 1425             


Thr Asn  Asn Val Tyr Lys Lys  His Arg Ile Leu Lys  Ile Tyr His 
    1430                 1435                 1440             


Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile Lys Ser  Gly Leu Gly 
    1445                 1450                 1455             


Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val Ile Tyr  Thr Leu Ile 
    1460                 1465                 1470             


His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile Met Asp  Val Ser Leu 
    1475                 1480                 1485             


Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu Ser Gln  Val Cys Gln 
    1490                 1495                 1500             


Thr Ala  Val Thr Tyr Cys Lys  Asp Ala Leu Glu Asn  His Leu His 
    1505                 1510                 1515             


Val Ile  Val Gly Thr Leu Ile  Pro Leu Val Tyr Glu  Gln Val Glu 
    1520                 1525                 1530             


Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys Tyr Leu  Val Ile Asp 
    1535                 1540                 1545             


Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Thr Ile Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Phe  Pro Asp His Val Val  Phe Lys Asp Leu Arg  Ile Thr Gln 
    1565                 1570                 1575             


Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe Ser Leu  Leu Glu Glu 
    1580                 1585                 1590             


Ile Asn  His Phe Leu Ser Val  Ser Val Tyr Asp Ala  Leu Pro Leu 
    1595                 1600                 1605             


Thr Arg  Leu Glu Gly Leu Lys  Asp Leu Arg Arg Gln  Leu Glu Leu 
    1610                 1615                 1620             


His Lys  Asp Gln Met Val Asp  Ile Met Arg Ala Ser  Gln Asp Asn 
    1625                 1630                 1635             


Pro Gln  Asp Gly Ile Met Val  Lys Leu Val Val Asn  Leu Leu Gln 
    1640                 1645                 1650             


Leu Ser  Lys Met Ala Ile Asn  His Thr Gly Glu Lys  Glu Val Leu 
    1655                 1660                 1665             


Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val Gly Pro  Ile Asp Phe 
    1670                 1675                 1680             


Ser Thr  Ile Ala Ile Gln His  Ser Lys Asp Ala Ser  Tyr Thr Lys 
    1685                 1690                 1695             


Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu Gln Trp  Thr Phe Ile 
    1700                 1705                 1710             


Met Leu  Thr Tyr Leu Asn Asn  Thr Leu Val Glu Asp  Cys Val Lys 
    1715                 1720                 1725             


Val Arg  Ser Ala Ala Val Thr  Cys Leu Lys Asn Ile  Leu Ala Thr 
    1730                 1735                 1740             


Lys Thr  Gly His Ser Phe Trp  Glu Ile Tyr Lys Met  Thr Thr Asp 
    1745                 1750                 1755             


Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg Thr Ser  Arg Lys Lys 
    1760                 1765                 1770             


Phe Leu  Glu Val Pro Arg Phe  Asp Lys Glu Asn Pro  Phe Glu Gly 
    1775                 1780                 1785             


Leu Asp  Asp Ile Asn Leu Trp  Ile Pro Leu Ser Glu  Asn His Asp 
    1790                 1795                 1800             


Ile Trp  Ile Lys Thr Leu Thr  Cys Ala Phe Leu Asp  Ser Gly Gly 
    1805                 1810                 1815             


Thr Lys  Cys Glu Ile Leu Gln  Leu Leu Lys Pro Met  Cys Glu Val 
    1820                 1825                 1830             


Lys Thr  Asp Phe Cys Gln Thr  Val Leu Pro Tyr Leu  Ile His Asp 
    1835                 1840                 1845             


Ile Leu  Leu Gln Asp Thr Asn  Glu Ser Trp Arg Asn  Leu Leu Ser 
    1850                 1855                 1860             


Thr His  Val Gln Gly Phe Phe  Thr Ser Cys Leu Arg  His Phe Ser 
    1865                 1870                 1875             


Gln Thr  Ser Arg Ser Thr Thr  Pro Ala Asn Leu Asp  Ser Glu Ser 
    1880                 1885                 1890             


Glu His  Phe Phe Arg Cys Cys  Leu Asp Lys Lys Ser  Gln Arg Thr 
    1895                 1900                 1905             


Met Leu  Ala Val Val Asp Tyr  Met Arg Arg Gln Lys  Arg Pro Ser 
    1910                 1915                 1920             


Ser Gly  Thr Ile Phe Asn Asp  Ala Phe Trp Leu Asp  Leu Asn Tyr 
    1925                 1930                 1935             


Leu Glu  Val Ala Lys Val Ala  Gln Ser Cys Ala Ala  His Phe Thr 
    1940                 1945                 1950             


Ala Leu  Leu Tyr Ala Glu Ile  Tyr Ala Asp Lys Lys  Ser Met Asp 
    1955                 1960                 1965             


Asp Gln  Glu Lys Arg Ser Leu  Ala Phe Glu Glu Gly  Ser Gln Ser 
    1970                 1975                 1980             


Thr Thr  Ile Ser Ser Leu Ser  Glu Lys Ser Lys Glu  Glu Thr Gly 
    1985                 1990                 1995             


Ile Ser  Leu Gln Asp Leu Leu  Leu Glu Ile Tyr Arg  Ser Ile Gly 
    2000                 2005                 2010             


Glu Pro  Asp Ser Leu Tyr Gly  Cys Gly Gly Gly Lys  Met Leu Gln 
    2015                 2020                 2025             


Pro Ile  Thr Arg Leu Arg Thr  Tyr Glu His Glu Ala  Met Trp Gly 
    2030                 2035                 2040             


Lys Ala  Leu Val Thr Tyr Asp  Leu Glu Thr Ala Ile  Pro Ser Ser 
    2045                 2050                 2055             


Thr Arg  Gln Ala Gly Ile Ile  Gln Ala Leu Gln Asn  Leu Gly Leu 
    2060                 2065                 2070             


Cys His  Ile Leu Ser Val Tyr  Leu Lys Gly Leu Asp  Tyr Glu Asn 
    2075                 2080                 2085             


Lys Asp  Trp Cys Pro Glu Leu  Glu Glu Leu His Tyr  Gln Ala Ala 
    2090                 2095                 2100             


Trp Arg  Asn Met Gln Trp Asp  His Cys Thr Ser Val  Ser Lys Glu 
    2105                 2110                 2115             


Val Glu  Gly Thr Ser Tyr His  Glu Ser Leu Tyr Asn  Ala Leu Gln 
    2120                 2125                 2130             


Ser Leu  Arg Asp Arg Glu Phe  Ser Thr Phe Tyr Glu  Ser Leu Lys 
    2135                 2140                 2145             


Tyr Ala  Arg Val Lys Glu Val  Glu Glu Met Cys Lys  Arg Ser Leu 
    2150                 2155                 2160             


Glu Ser  Val Tyr Ser Leu Tyr  Pro Thr Leu Ser Arg  Leu Gln Ala 
    2165                 2170                 2175             


Ile Gly  Glu Leu Glu Ser Ile  Gly Glu Leu Phe Ser  Arg Ser Val 
    2180                 2185                 2190             


Thr His  Arg Gln Leu Ser Glu  Val Tyr Ile Lys Trp  Gln Lys His 
    2195                 2200                 2205             


Ser Gln  Leu Leu Lys Asp Ser  Asp Phe Ser Phe Gln  Glu Pro Ile 
    2210                 2215                 2220             


Met Ala  Leu Arg Thr Val Ile  Leu Glu Ile Leu Met  Glu Lys Glu 
    2225                 2230                 2235             


Met Asp  Asn Ser Gln Arg Glu  Cys Ile Lys Asp Ile  Leu Thr Lys 
    2240                 2245                 2250             


His Leu  Val Glu Leu Ser Ile  Leu Ala Arg Thr Phe  Lys Asn Thr 
    2255                 2260                 2265             


Gln Leu  Pro Glu Arg Ala Ile  Phe Gln Ile Lys Gln  Tyr Asn Ser 
    2270                 2275                 2280             


Val Ser  Cys Gly Val Ser Glu  Trp Gln Leu Glu Glu  Ala Gln Val 
    2285                 2290                 2295             


Phe Trp  Ala Lys Lys Glu Gln  Ser Leu Ala Leu Ser  Ile Leu Lys 
    2300                 2305                 2310             


Gln Met  Ile Lys Lys Leu Asp  Ala Ser Cys Ala Ala  Asn Asn Pro 
    2315                 2320                 2325             


Ser Leu  Lys Leu Thr Tyr Thr  Glu Cys Leu Arg Val  Cys Gly Asn 
    2330                 2335                 2340             


Trp Leu  Ala Glu Thr Cys Leu  Glu Asn Pro Ala Val  Ile Met Gln 
    2345                 2350                 2355             


Thr Tyr  Leu Glu Lys Ala Val  Glu Val Ala Gly Asn  Tyr Asp Gly 
    2360                 2365                 2370             


Glu Ser  Ser Asp Glu Leu Arg  Asn Gly Lys Met Lys  Ala Phe Leu 
    2375                 2380                 2385             


Ser Leu  Ala Arg Phe Ser Asp  Thr Gln Tyr Gln Arg  Ile Glu Asn 
    2390                 2395                 2400             


Tyr Met  Lys Ser Ser Glu Phe  Glu Asn Lys Gln Ala  Leu Leu Lys 
    2405                 2410                 2415             


Arg Ala  Lys Glu Glu Val Gly  Leu Leu Arg Glu His  Lys Ile Gln 
    2420                 2425                 2430             


Thr Asn  Arg Tyr Thr Val Lys  Val Gln Arg Glu Leu  Glu Leu Asp 
    2435                 2440                 2445             


Glu Leu  Ala Leu Arg Ala Leu  Lys Glu Asp Arg Lys  Arg Phe Leu 
    2450                 2455                 2460             


Cys Lys  Ala Val Glu Asn Tyr  Ile Asn Cys Leu Leu  Ser Gly Glu 
    2465                 2470                 2475             


Glu His  Asp Met Trp Val Phe  Arg Leu Cys Ser Leu  Trp Leu Glu 
    2480                 2485                 2490             


Asn Ser  Gly Val Ser Glu Val  Asn Gly Met Met Lys  Arg Asp Gly 
    2495                 2500                 2505             


Met Lys  Ile Pro Thr Tyr Lys  Phe Leu Pro Leu Met  Tyr Gln Leu 
    2510                 2515                 2520             


Ala Ala  Arg Met Gly Thr Lys  Met Met Gly Gly Leu  Gly Phe His 
    2525                 2530                 2535             


Glu Val  Leu Asn Asn Leu Ile  Ser Arg Ile Ser Met  Asp His Pro 
    2540                 2545                 2550             


His His  Thr Leu Phe Ile Ile  Leu Ala Leu Ala Asn  Ala Asn Arg 
    2555                 2560                 2565             


Asp Glu  Phe Leu Thr Lys Pro  Glu Val Ala Arg Arg  Ser Arg Ile 
    2570                 2575                 2580             


Thr Lys  Asn Val Pro Lys Gln  Ser Ser Gln Leu Asp  Glu Asp Arg 
    2585                 2590                 2595             


Thr Glu  Ala Ala Asn Arg Ile  Ile Cys Thr Ile Arg  Ser Arg Arg 
    2600                 2605                 2610             


Pro Gln  Met Val Arg Ser Val  Glu Ala Leu Cys Asp  Ala Tyr Ile 
    2615                 2620                 2625             


Ile Leu  Ala Asn Leu Asp Ala  Thr Gln Trp Lys Thr  Gln Arg Lys 
    2630                 2635                 2640             


Gly Ile  Asn Ile Pro Ala Asp  Gln Pro Ile Thr Lys  Leu Lys Asn 
    2645                 2650                 2655             


Leu Glu  Asp Val Val Val Pro  Thr Met Glu Ile Lys  Val Asp His 
    2660                 2665                 2670             


Thr Gly  Glu Tyr Gly Asn Leu  Val Thr Ile Gln Ser  Phe Lys Ala 
    2675                 2680                 2685             


Glu Phe  Arg Leu Ala Gly Gly  Val Asn Leu Pro Lys  Ile Ile Asp 
    2690                 2695                 2700             


Cys Val  Gly Ser Asp Gly Lys  Glu Arg Arg Gln Leu  Val Lys Gly 
    2705                 2710                 2715             


Arg Asp  Asp Leu Arg Gln Asp  Ala Val Met Gln Gln  Val Phe Gln 
    2720                 2725                 2730             


Met Cys  Asn Thr Leu Leu Gln  Arg Asn Thr Glu Thr  Arg Lys Arg 
    2735                 2740                 2745             


Lys Leu  Thr Ile Cys Thr Tyr  Lys Val Val Pro Leu  Ser Gln Arg 
    2750                 2755                 2760             


Ser Gly  Val Leu Glu Trp Cys  Thr Gly Thr Val Pro  Ile Gly Glu 
    2765                 2770                 2775             


Phe Leu  Val Asn Asn Glu Asp  Gly Ala His Lys Arg  Tyr Arg Pro 
    2780                 2785                 2790             


Asn Asp  Phe Ser Ala Phe Gln  Cys Gln Lys Lys Met  Met Glu Val 
    2795                 2800                 2805             


Gln Lys  Lys Ser Phe Glu Glu  Lys Tyr Glu Val Phe  Met Asp Val 
    2810                 2815                 2820             


Cys Gln  Asn Phe Gln Pro Val  Phe Arg Tyr Phe Cys  Met Glu Lys 
    2825                 2830                 2835             


Phe Leu  Asp Pro Ala Ile Trp  Phe Glu Lys Arg Leu  Ala Tyr Thr 
    2840                 2845                 2850             


Arg Ser  Val Ala Thr Ser Ser  Ile Val Gly Tyr Ile  Leu Gly Leu 
    2855                 2860                 2865             


Gly Asp  Arg His Val Gln Asn  Ile Leu Ile Asn Glu  Gln Ser Ala 
    2870                 2875                 2880             


Glu Leu  Val His Ile Asp Leu  Gly Val Ala Phe Glu  Gln Gly Lys 
    2885                 2890                 2895             


Ile Leu  Pro Thr Pro Glu Thr  Val Pro Phe Arg Leu  Thr Arg Asp 
    2900                 2905                 2910             


Ile Val  Asp Gly Met Gly Ile  Thr Gly Val Glu Gly  Val Phe Arg 
    2915                 2920                 2925             


Arg Cys  Cys Glu Lys Thr Met  Glu Val Met Arg Asn  Ser Gln Glu 
    2930                 2935                 2940             


Thr Leu  Leu Thr Ile Val Glu  Val Leu Leu Tyr Asp  Pro Leu Phe 
    2945                 2950                 2955             


Asp Trp  Thr Met Asn Pro Leu  Lys Ala Leu Tyr Leu  Gln Gln Arg 
    2960                 2965                 2970             


Pro Glu  Asp Glu Thr Glu Leu  His Pro Thr Leu Asn  Ala Asp Asp 
    2975                 2980                 2985             


Gln Glu  Cys Lys Arg Asn Leu  Ser Asp Ile Asp Gln  Ser Phe Asp 
    2990                 2995                 3000             


Lys Val  Ala Glu Arg Val Leu  Met Arg Leu Gln Glu  Lys Leu Lys 
    3005                 3010                 3015             


Gly Val  Glu Glu Gly Thr Val  Leu Ser Val Gly Gly  Gln Val Asn 
    3020                 3025                 3030             


Leu Leu  Ile Gln Gln Ala Ile  Asp Pro Lys Asn Leu  Ser Arg Leu 
    3035                 3040                 3045             


Phe Pro  Gly Trp Lys Ala Trp  Val 
    3050                 3055     


<210>  218
<211>  830
<212>  PRT
<213>  homo sapiens

<400>  218

Ala Ala Gly Ile Gly Lys Leu Ser Thr Ala Asp Gly Lys Ala Phe Ala 
1               5                   10                  15      


Asp Pro Glu Val Leu Arg Arg Leu Thr Ser Ser Val Ser Cys Ala Leu 
            20                  25                  30          


Asp Glu Ala Ala Ala Ala Leu Thr Arg Met Arg Ala Glu Ser Thr Ala 
        35                  40                  45              


Asn Ala Gly Gln Ser Asp Asn Arg Ser Leu Ala Glu Ala Cys Ser Glu 
    50                  55                  60                  


Gly Asp Val Asn Ala Val Arg Lys Leu Leu Ile Glu Gly Arg Ser Val 
65                  70                  75                  80  


Asn Glu His Thr Glu Glu Gly Glu Ser Leu Leu Cys Leu Ala Cys Ser 
                85                  90                  95      


Ala Gly Tyr Tyr Glu Leu Ala Gln Val Leu Leu Ala Met His Ala Asn 
            100                 105                 110         


Val Glu Asp Arg Gly Ile Lys Gly Asp Ile Thr Pro Leu Met Ala Ala 
        115                 120                 125             


Ala Asn Gly Gly His Val Lys Ile Val Lys Leu Leu Leu Ala His Lys 
    130                 135                 140                 


Ala Asp Val Asn Ala Gln Ser Ser Thr Gly Asn Thr Ala Leu Thr Tyr 
145                 150                 155                 160 


Ala Cys Ala Gly Gly Tyr Val Asp Val Val Lys Val Leu Leu Glu Ser 
                165                 170                 175     


Gly Ala Ser Ile Glu Asp His Asn Glu Asn Gly His Thr Pro Leu Met 
            180                 185                 190         


Glu Ala Gly Ser Ala Gly His Val Glu Val Ala Arg Leu Leu Leu Glu 
        195                 200                 205             


Asn Gly Ala Gly Ile Asn Thr His Ser Asn Glu Phe Lys Glu Ser Ala 
    210                 215                 220                 


Leu Thr Leu Ala Cys Tyr Lys Gly His Leu Glu Met Val Arg Phe Leu 
225                 230                 235                 240 


Leu Glu Ala Gly Ala Asp Gln Glu His Lys Thr Asp Glu Met His Thr 
                245                 250                 255     


Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu Val Ala Arg Leu 
            260                 265                 270         


Leu Leu Asp Ser Gly Ala Gln Val Asn Met Pro Ala Asp Ser Phe Glu 
        275                 280                 285             


Ser Pro Leu Thr Leu Ala Ala Cys Gly Gly His Val Glu Leu Ala Ala 
    290                 295                 300                 


Leu Leu Ile Glu Arg Gly Ala Ser Leu Glu Glu Val Asn Asp Glu Gly 
305                 310                 315                 320 


Tyr Thr Pro Leu Met Glu Ala Ala Arg Glu Gly His Glu Glu Met Val 
                325                 330                 335     


Ala Leu Leu Leu Gly Gln Gly Ala Asn Ile Asn Ala Gln Thr Glu Glu 
            340                 345                 350         


Thr Gln Glu Thr Ala Leu Thr Leu Ala Cys Cys Gly Gly Phe Leu Glu 
        355                 360                 365             


Val Ala Asp Phe Leu Ile Lys Ala Gly Ala Asp Ile Glu Leu Gly Cys 
    370                 375                 380                 


Ser Thr Pro Leu Met Glu Ala Ala Gln Glu Gly His Leu Glu Leu Val 
385                 390                 395                 400 


Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala Thr Thr Ala Thr 
                405                 410                 415     


Gly Asp Thr Ala Leu Thr Tyr Ala Cys Glu Asn Gly His Thr Asp Val 
            420                 425                 430         


Ala Asp Val Leu Leu Gln Ala Gly Ala Asp Leu Glu His Glu Ser Glu 
        435                 440                 445             


Gly Gly Arg Thr Pro Leu Met Lys Ala Ala Arg Ala Gly His Val Cys 
    450                 455                 460                 


Thr Val Gln Phe Leu Ile Ser Lys Gly Ala Asn Val Asn Arg Thr Thr 
465                 470                 475                 480 


Ala Asn Asn Asp His Thr Val Leu Ser Leu Ala Cys Ala Gly Gly His 
                485                 490                 495     


Leu Ala Val Val Glu Leu Leu Leu Ala His Gly Ala Asp Pro Thr His 
            500                 505                 510         


Arg Leu Lys Asp Gly Ser Thr Met Leu Ile Glu Ala Ala Lys Gly Gly 
        515                 520                 525             


His Thr Ser Val Val Cys Tyr Leu Leu Asp Tyr Pro Asn Asn Leu Leu 
    530                 535                 540                 


Ser Ala Pro Pro Pro Asp Val Thr Gln Leu Thr Pro Pro Ser His Asp 
545                 550                 555                 560 


Leu Asn Arg Ala Pro Arg Val Pro Val Gln Ala Leu Pro Met Val Val 
                565                 570                 575     


Pro Pro Gln Glu Pro Asp Lys Pro Pro Ala Asn Val Ala Thr Thr Leu 
            580                 585                 590         


Pro Ile Arg Asn Lys Ala Ala Ser Lys Gln Lys Ser Ser Ser His Leu 
        595                 600                 605             


Pro Ala Asn Ser Gln Asp Val Gln Gly Tyr Ile Thr Asn Gln Ser Pro 
    610                 615                 620                 


Glu Ser Ile Val Glu Glu Ala Gln Gly Lys Leu Thr Glu Leu Glu Gln 
625                 630                 635                 640 


Arg Ile Lys Glu Ala Ile Glu Lys Asn Ala Gln Leu Gln Ser Leu Glu 
                645                 650                 655     


Leu Ala His Ala Asp Gln Leu Thr Lys Glu Lys Ile Glu Glu Leu Asn 
            660                 665                 670         


Lys Thr Arg Glu Glu Gln Ile Gln Lys Lys Gln Lys Ile Leu Glu Glu 
        675                 680                 685             


Leu Gln Lys Val Glu Arg Glu Leu Gln Leu Lys Thr Gln Gln Gln Leu 
    690                 695                 700                 


Lys Lys Gln Tyr Leu Glu Val Lys Ala Gln Arg Ile Gln Leu Gln Gln 
705                 710                 715                 720 


Gln Gln Gln Gln Ser Cys Gln His Leu Gly Leu Leu Thr Pro Val Gly 
                725                 730                 735     


Val Gly Glu Gln Leu Ser Glu Gly Asp Tyr Ala Arg Leu Gln Gln Val 
            740                 745                 750         


Asp Pro Val Leu Leu Lys Asp Glu Pro Gln Gln Thr Ala Ala Gln Met 
        755                 760                 765             


Gly Phe Ala Pro Ile Gln Pro Leu Ala Met Pro Gln Ala Leu Pro Leu 
    770                 775                 780                 


Ala Ala Gly Pro Leu Pro Pro Gly Ser Ile Ala Asn Leu Thr Glu Leu 
785                 790                 795                 800 


Gln Val Leu Ser Ser Leu Leu Gln Pro Cys Phe Leu Ser Thr Leu Pro 
                805                 810                 815     


Leu Ile Leu Met His Arg Leu Arg Val Ile Met Thr Arg Arg 
            820                 825                 830 


<210>  219
<211>  93
<212>  PRT
<213>  homo sapiens

<400>  219

Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val Thr Gly Ser Arg Glu 
1               5                   10                  15      


Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile Leu Asp Gly Lys Arg 
            20                  25                  30          


Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn Ala Leu Arg Asp 
        35                  40                  45              


Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala Thr Pro Pro Gln Ile 
    50                  55                  60                  


Val Asn Gly Asp Gln Tyr Cys Gly Asp Tyr Glu Leu Phe Val Glu Ala 
65                  70                  75                  80  


Val Glu Gln Asn Thr Leu Gln Glu Phe Leu Lys Leu Ala 
                85                  90              


<210>  220
<211>  847
<212>  PRT
<213>  homo sapiens

<400>  220

Met Ser Leu Trp Gly Leu Val Ser Lys Met Pro Pro Glu Lys Val Gln 
1               5                   10                  15      


Arg Leu Tyr Val Asp Phe Pro Gln His Leu Arg His Leu Leu Gly Asp 
            20                  25                  30          


Trp Leu Glu Ser Gln Pro Trp Glu Phe Leu Val Gly Ser Asp Ala Phe 
        35                  40                  45              


Cys Cys Asn Leu Ala Ser Ala Leu Leu Ser Asp Thr Val Gln His Leu 
    50                  55                  60                  


Gln Ala Ser Val Gly Glu Gln Gly Glu Gly Ser Thr Ile Leu Gln His 
65                  70                  75                  80  


Ile Ser Thr Leu Glu Ser Ile Tyr Gln Arg Asp Pro Leu Lys Leu Val 
                85                  90                  95      


Ala Thr Phe Arg Gln Ile Leu Gln Gly Glu Lys Lys Ala Val Met Glu 
            100                 105                 110         


Gln Phe Arg His Leu Pro Met Pro Phe His Trp Lys Gln Glu Glu Leu 
        115                 120                 125             


Lys Phe Lys Thr Gly Leu Arg Arg Leu Gln His Arg Val Gly Glu Ile 
    130                 135                 140                 


His Leu Leu Arg Glu Ala Leu Gln Lys Gly Ala Glu Ala Gly Gln Val 
145                 150                 155                 160 


Ser Leu His Ser Leu Ile Glu Thr Pro Ala Asn Gly Thr Gly Pro Ser 
                165                 170                 175     


Glu Ala Leu Ala Met Leu Leu Gln Glu Thr Thr Gly Glu Leu Glu Ala 
            180                 185                 190         


Ala Lys Ala Leu Val Leu Lys Arg Ile Gln Ile Trp Lys Arg Gln Gln 
        195                 200                 205             


Gln Leu Ala Gly Asn Gly Ala Pro Phe Glu Glu Ser Leu Ala Pro Leu 
    210                 215                 220                 


Gln Glu Arg Cys Glu Ser Leu Val Asp Ile Tyr Ser Gln Leu Gln Gln 
225                 230                 235                 240 


Glu Val Gly Ala Ala Gly Gly Glu Leu Glu Pro Lys Thr Arg Ala Ser 
                245                 250                 255     


Leu Thr Gly Arg Leu Asp Glu Val Leu Arg Thr Leu Val Thr Ser Cys 
            260                 265                 270         


Phe Leu Val Glu Lys Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys 
        275                 280                 285             


Phe Gln Ala Gly Val Arg Phe Leu Leu Gly Leu Arg Phe Leu Gly Ala 
    290                 295                 300                 


Pro Ala Lys Pro Pro Leu Val Arg Ala Asp Met Val Thr Glu Lys Gln 
305                 310                 315                 320 


Ala Arg Glu Leu Ser Val Pro Gln Gly Pro Gly Ala Gly Ala Glu Ser 
                325                 330                 335     


Thr Gly Glu Ile Ile Asn Asn Thr Val Pro Leu Glu Asn Ser Ile Pro 
            340                 345                 350         


Gly Asn Cys Cys Ser Ala Leu Phe Lys Asn Leu Leu Leu Lys Lys Ile 
        355                 360                 365             


Lys Arg Cys Glu Arg Lys Gly Thr Glu Ser Val Thr Glu Glu Lys Cys 
    370                 375                 380                 


Ala Val Leu Phe Ser Ala Ser Phe Thr Leu Gly Pro Gly Lys Leu Pro 
385                 390                 395                 400 


Ile Gln Leu Gln Ala Leu Ser Leu Pro Leu Val Val Ile Val His Gly 
                405                 410                 415     


Asn Gln Asp Asn Asn Ala Lys Ala Thr Ile Leu Trp Asp Asn Ala Phe 
            420                 425                 430         


Ser Glu Met Asp Arg Val Pro Phe Val Val Ala Glu Arg Val Pro Trp 
        435                 440                 445             


Glu Lys Met Cys Glu Thr Leu Asn Leu Lys Phe Met Ala Glu Val Gly 
    450                 455                 460                 


Thr Asn Arg Gly Leu Leu Pro Glu His Phe Leu Phe Leu Ala Gln Lys 
465                 470                 475                 480 


Ile Phe Asn Asp Asn Ser Leu Ser Met Glu Ala Phe Gln His Arg Ser 
                485                 490                 495     


Val Ser Trp Ser Gln Phe Asn Lys Glu Ile Leu Leu Gly Arg Gly Phe 
            500                 505                 510         


Thr Phe Trp Gln Trp Phe Asp Gly Val Leu Asp Leu Thr Lys Arg Cys 
        515                 520                 525             


Leu Arg Ser Tyr Trp Ser Asp Arg Leu Ile Ile Gly Phe Ile Ser Lys 
    530                 535                 540                 


Gln Tyr Val Thr Ser Leu Leu Leu Asn Glu Pro Asp Gly Thr Phe Leu 
545                 550                 555                 560 


Leu Arg Phe Ser Asp Ser Glu Ile Gly Gly Ile Thr Ile Ala His Val 
                565                 570                 575     


Ile Arg Gly Gln Asp Gly Ser Pro Gln Ile Glu Asn Ile Gln Pro Phe 
            580                 585                 590         


Ser Ala Lys Asp Leu Ser Ile Arg Ser Leu Gly Asp Arg Ile Arg Asp 
        595                 600                 605             


Leu Ala Gln Leu Lys Asn Leu Tyr Pro Lys Lys Pro Lys Asp Glu Ala 
    610                 615                 620                 


Phe Arg Ser His Tyr Lys Pro Glu Gln Met Gly Lys Asp Gly Arg Gly 
625                 630                 635                 640 


Tyr Val Pro Ala Thr Ile Lys Met Thr Val Glu Arg Asp Gln Pro Leu 
                645                 650                 655     


Pro Thr Pro Glu Leu Gln Met Pro Thr Met Val Pro Ser Tyr Asp Leu 
            660                 665                 670         


Gly Met Ala Pro Asp Ser Ser Met Ser Met Gln Leu Gly Pro Asp Met 
        675                 680                 685             


Val Pro Gln Val Tyr Pro Pro His Ser His Ser Ile Pro Pro Tyr Gln 
    690                 695                 700                 


Gly Leu Ser Pro Glu Glu Ser Val Asn Val Leu Ser Ala Phe Gln Glu 
705                 710                 715                 720 


Pro His Leu Gln Met Pro Pro Ser Leu Gly Gln Met Ser Leu Pro Phe 
                725                 730                 735     


Asp Gln Pro His Pro Gln Gly Leu Leu Pro Cys Gln Pro Gln Glu His 
            740                 745                 750         


Ala Val Ser Ser Pro Asp Pro Leu Leu Cys Ser Asp Val Thr Met Val 
        755                 760                 765             


Glu Asp Ser Cys Leu Ser Gln Pro Val Thr Ala Phe Pro Gln Gly Thr 
    770                 775                 780                 


Trp Ile Gly Glu Asp Ile Phe Pro Pro Leu Leu Pro Pro Thr Glu Gln 
785                 790                 795                 800 


Asp Leu Thr Lys Leu Leu Leu Glu Gly Gln Gly Glu Ser Gly Gly Gly 
                805                 810                 815     


Ser Leu Gly Ala Gln Pro Leu Leu Gln Pro Ser His Tyr Gly Gln Ser 
            820                 825                 830         


Gly Ile Ser Met Ser His Met Asp Leu Arg Ala Asn Pro Ser Trp 
        835                 840                 845         


<210>  221
<211>  910
<212>  PRT
<213>  homo sapiens

<400>  221

Met Asp Thr Ala Glu Glu Asp Ile Cys Arg Val Cys Arg Ser Glu Gly 
1               5                   10                  15      


Thr Pro Glu Lys Pro Leu Tyr His Pro Cys Val Cys Thr Gly Ser Ile 
            20                  25                  30          


Lys Phe Ile His Gln Glu Cys Leu Val Gln Trp Leu Lys His Ser Arg 
        35                  40                  45              


Lys Glu Tyr Cys Glu Leu Cys Lys His Arg Phe Ala Phe Thr Pro Ile 
    50                  55                  60                  


Tyr Ser Pro Asp Met Pro Ser Arg Leu Pro Ile Gln Asp Ile Phe Ala 
65                  70                  75                  80  


Gly Leu Val Thr Ser Ile Gly Thr Ala Ile Arg Tyr Trp Phe His Tyr 
                85                  90                  95      


Thr Leu Val Ala Phe Ala Trp Leu Gly Val Val Pro Leu Thr Ala Cys 
            100                 105                 110         


Arg Ile Tyr Lys Cys Leu Phe Thr Gly Ser Val Ser Ser Leu Leu Thr 
        115                 120                 125             


Leu Pro Leu Asp Met Leu Ser Thr Glu Asn Leu Leu Ala Asp Cys Leu 
    130                 135                 140                 


Gln Gly Cys Phe Val Val Thr Cys Thr Leu Cys Ala Phe Ile Ser Leu 
145                 150                 155                 160 


Val Trp Leu Arg Glu Gln Ile Val His Gly Gly Ala Pro Ile Trp Leu 
                165                 170                 175     


Glu His Ala Ala Pro Pro Phe Asn Ala Ala Gly His His Gln Asn Glu 
            180                 185                 190         


Ala Pro Ala Gly Gly Asn Gly Ala Glu Asn Val Ala Ala Asp Gln Pro 
        195                 200                 205             


Ala Asn Pro Pro Ala Glu Asn Ala Val Val Gly Glu Asn Pro Asp Ala 
    210                 215                 220                 


Gln Asp Asp Gln Ala Glu Glu Glu Glu Glu Asp Asn Glu Glu Glu Asp 
225                 230                 235                 240 


Asp Ala Gly Val Glu Asp Ala Ala Asp Ala Asn Asn Gly Ala Gln Asp 
                245                 250                 255     


Asp Met Asn Trp Asn Ala Leu Glu Trp Asp Arg Ala Ala Glu Glu Leu 
            260                 265                 270         


Thr Trp Glu Arg Met Leu Gly Leu Asp Gly Ser Leu Val Phe Leu Glu 
        275                 280                 285             


His Val Phe Trp Val Val Ser Leu Asn Thr Leu Phe Ile Leu Val Phe 
    290                 295                 300                 


Ala Phe Cys Pro Tyr His Ile Gly His Phe Ser Leu Val Gly Leu Gly 
305                 310                 315                 320 


Phe Glu Glu His Val Gln Ala Ser His Phe Glu Gly Leu Ile Thr Thr 
                325                 330                 335     


Ile Val Gly Tyr Ile Leu Leu Ala Ile Thr Leu Ile Ile Cys His Gly 
            340                 345                 350         


Leu Ala Thr Leu Val Lys Phe His Arg Ser Arg Arg Leu Leu Gly Val 
        355                 360                 365             


Cys Tyr Ile Val Val Lys Val Ser Leu Leu Val Val Val Glu Ile Gly 
    370                 375                 380                 


Val Phe Pro Leu Ile Cys Gly Trp Trp Leu Asp Ile Cys Ser Leu Glu 
385                 390                 395                 400 


Met Phe Asp Ala Thr Leu Lys Asp Arg Glu Leu Ser Phe Gln Ser Ala 
                405                 410                 415     


Pro Gly Thr Thr Met Phe Leu His Trp Leu Val Gly Met Val Tyr Val 
            420                 425                 430         


Phe Tyr Phe Ala Ser Phe Ile Leu Leu Leu Arg Glu Val Leu Arg Pro 
        435                 440                 445             


Gly Val Leu Trp Phe Leu Arg Asn Leu Asn Asp Pro Asp Phe Asn Pro 
    450                 455                 460                 


Val Gln Glu Met Ile His Leu Pro Ile Tyr Arg His Leu Arg Arg Phe 
465                 470                 475                 480 


Ile Leu Ser Val Ile Val Phe Gly Ser Ile Val Leu Leu Met Leu Trp 
                485                 490                 495     


Leu Pro Ile Arg Ile Ile Lys Ser Val Leu Pro Asn Phe Leu Pro Tyr 
            500                 505                 510         


Asn Val Met Leu Tyr Ser Asp Ala Pro Val Ser Glu Leu Ser Leu Glu 
        515                 520                 525             


Leu Leu Leu Leu Gln Val Val Leu Pro Ala Leu Leu Glu Gln Gly His 
    530                 535                 540                 


Thr Arg Gln Trp Leu Lys Gly Leu Val Arg Ala Trp Thr Val Thr Ala 
545                 550                 555                 560 


Gly Tyr Leu Leu Asp Leu His Ser Tyr Leu Leu Gly Asp Gln Glu Glu 
                565                 570                 575     


Asn Glu Asn Ser Ala Asn Gln Gln Val Asn Asn Asn Gln His Ala Arg 
            580                 585                 590         


Asn Asn Asn Ala Ile Pro Val Val Gly Glu Gly Leu His Ala Ala His 
        595                 600                 605             


Gln Ala Ile Leu Gln Gln Gly Gly Pro Val Gly Phe Gln Pro Tyr Arg 
    610                 615                 620                 


Arg Pro Leu Asn Phe Pro Leu Arg Ile Phe Leu Leu Ile Val Phe Met 
625                 630                 635                 640 


Cys Ile Thr Leu Leu Ile Ala Ser Leu Ile Cys Leu Thr Leu Pro Val 
                645                 650                 655     


Phe Ala Gly Arg Trp Leu Met Ser Phe Trp Thr Gly Thr Ala Lys Ile 
            660                 665                 670         


His Glu Leu Tyr Thr Ala Ala Cys Gly Leu Tyr Val Cys Trp Leu Thr 
        675                 680                 685             


Ile Arg Ala Val Thr Val Met Val Ala Trp Met Pro Gln Gly Arg Arg 
    690                 695                 700                 


Val Ile Phe Gln Lys Val Lys Glu Trp Ser Leu Met Ile Met Lys Thr 
705                 710                 715                 720 


Leu Ile Val Ala Val Leu Leu Ala Gly Val Val Pro Leu Leu Leu Gly 
                725                 730                 735     


Leu Leu Phe Glu Leu Val Ile Val Ala Pro Leu Arg Val Pro Leu Asp 
            740                 745                 750         


Gln Thr Pro Leu Phe Tyr Pro Trp Gln Asp Trp Ala Leu Gly Val Leu 
        755                 760                 765             


His Ala Lys Ile Ile Ala Ala Ile Thr Leu Met Gly Pro Gln Trp Trp 
    770                 775                 780                 


Leu Lys Thr Val Ile Glu Gln Val Tyr Ala Asn Gly Ile Arg Asn Ile 
785                 790                 795                 800 


Asp Leu His Tyr Ile Val Arg Lys Leu Ala Ala Pro Val Ile Ser Val 
                805                 810                 815     


Leu Leu Leu Ser Leu Cys Val Pro Tyr Val Ile Ala Ser Gly Val Val 
            820                 825                 830         


Pro Leu Leu Gly Val Thr Ala Glu Met Gln Asn Leu Val His Arg Arg 
        835                 840                 845             


Ile Tyr Pro Phe Leu Leu Met Val Val Val Leu Met Ala Ile Leu Ser 
    850                 855                 860                 


Phe Gln Val Arg Gln Phe Lys Arg Leu Tyr Glu His Ile Lys Asn Asp 
865                 870                 875                 880 


Lys Tyr Leu Val Gly Gln Arg Leu Val Asn Tyr Glu Arg Lys Ser Gly 
                885                 890                 895     


Lys Gln Gly Ser Ser Pro Pro Pro Pro Gln Ser Ser Gln Glu 
            900                 905                 910 


<210>  222
<211>  292
<212>  PRT
<213>  homo sapiens

<400>  222

Met Gly Glu Lys Ser Glu Asn Cys Gly Val Pro Glu Asp Leu Leu Asn 
1               5                   10                  15      


Gly Leu Lys Val Thr Asp Thr Gln Glu Ala Glu Cys Ala Gly Pro Pro 
            20                  25                  30          


Val Pro Asp Pro Lys Asn Gln His Ser Gln Ser Lys Leu Leu Arg Asp 
        35                  40                  45              


Asp Glu Ala His Leu Gln Glu Asp Gln Gly Glu Glu Glu Cys Phe His 
    50                  55                  60                  


Asp Cys Ser Ala Ser Phe Glu Glu Glu Pro Gly Ala Asp Lys Val Glu 
65                  70                  75                  80  


Asn Lys Ser Asn Glu Asp Val Asn Ser Ser Glu Leu Asp Glu Glu Tyr 
                85                  90                  95      


Leu Ile Glu Leu Glu Lys Asn Met Ser Asp Glu Glu Lys Gln Lys Arg 
            100                 105                 110         


Arg Glu Glu Ser Thr Arg Leu Lys Glu Glu Gly Asn Glu Gln Phe Lys 
        115                 120                 125             


Lys Gly Asp Tyr Ile Glu Ala Glu Ser Ser Tyr Ser Arg Ala Leu Glu 
    130                 135                 140                 


Met Cys Pro Ser Cys Phe Gln Lys Glu Arg Ser Ile Leu Phe Ser Asn 
145                 150                 155                 160 


Arg Ala Ala Ala Arg Met Lys Gln Asp Lys Lys Glu Met Ala Ile Asn 
                165                 170                 175     


Asp Cys Ser Lys Ala Ile Gln Leu Asn Pro Ser Tyr Ile Arg Ala Ile 
            180                 185                 190         


Leu Arg Arg Ala Glu Leu Tyr Glu Lys Thr Asp Lys Leu Asp Glu Ala 
        195                 200                 205             


Leu Glu Asp Tyr Lys Ser Ile Leu Glu Lys Asp Pro Ser Ile His Gln 
    210                 215                 220                 


Ala Arg Glu Ala Cys Met Arg Leu Pro Lys Gln Ile Glu Glu Arg Asn 
225                 230                 235                 240 


Glu Arg Leu Lys Glu Glu Met Leu Gly Lys Leu Lys Asp Leu Gly Asn 
                245                 250                 255     


Leu Val Leu Arg Pro Phe Gly Leu Ser Thr Glu Asn Phe Gln Ile Lys 
            260                 265                 270         


Gln Asp Ser Ser Thr Gly Ser Tyr Ser Ile Asn Phe Val Gln Asn Pro 
        275                 280                 285             


Asn Asn Asn Arg 
    290         


<210>  223
<211>  206
<212>  PRT
<213>  homo sapiens

<400>  223

Met Arg Arg Thr Gly Ala Pro Ala Gln Ala Asp Ser Arg Gly Arg Gly 
1               5                   10                  15      


Arg Ala Arg Gly Gly Cys Pro Gly Gly Glu Ala Thr Leu Ser Gln Pro 
            20                  25                  30          


Pro Pro Arg Gly Gly Thr Arg Gly Gln Glu Pro Gln Met Lys Glu Thr 
        35                  40                  45              


Ile Met Asn Gln Glu Lys Leu Ala Lys Leu Gln Ala Gln Val Arg Ile 
    50                  55                  60                  


Gly Gly Lys Gly Thr Ala Arg Arg Lys Lys Lys Val Val His Arg Thr 
65                  70                  75                  80  


Ala Thr Ala Asp Asp Lys Lys Leu Gln Phe Ser Leu Lys Lys Leu Gly 
                85                  90                  95      


Val Asn Asn Ile Ser Gly Ile Glu Glu Val Asn Met Phe Thr Asn Gln 
            100                 105                 110         


Gly Thr Val Ile His Phe Asn Asn Pro Lys Val Gln Ala Ser Leu Ala 
        115                 120                 125             


Ala Asn Thr Phe Thr Ile Thr Gly His Ala Glu Thr Lys Gln Leu Thr 
    130                 135                 140                 


Glu Met Leu Pro Ser Ile Leu Asn Gln Leu Gly Ala Asp Ser Leu Thr 
145                 150                 155                 160 


Ser Leu Arg Arg Leu Ala Glu Ala Leu Pro Lys Gln Ser Val Asp Gly 
                165                 170                 175     


Lys Ala Pro Leu Ala Thr Gly Glu Asp Asp Asp Asp Glu Val Pro Asp 
            180                 185                 190         


Leu Val Glu Asn Phe Asp Glu Ala Ser Lys Asn Glu Ala Asn 
        195                 200                 205     


<210>  224
<211>  410
<212>  PRT
<213>  homo sapiens

<400>  224

Met Ala Lys Asp Ala Gly Leu Ile Glu Ala Asn Gly Glu Leu Lys Val 
1               5                   10                  15      


Phe Ile Asp Gln Asn Leu Ser Pro Gly Lys Gly Val Val Ser Leu Val 
            20                  25                  30          


Ala Val His Pro Ser Thr Val Asn Pro Leu Gly Lys Gln Leu Leu Pro 
        35                  40                  45              


Lys Thr Phe Gly Gln Ser Asn Val Asn Ile Ala Gln Gln Val Val Ile 
    50                  55                  60                  


Gly Thr Pro Gln Arg Pro Ala Ala Ser Asn Thr Leu Val Val Gly Ser 
65                  70                  75                  80  


Pro His Thr Pro Ser Thr His Phe Ala Ser Gln Asn Gln Pro Ser Asp 
                85                  90                  95      


Ser Ser Pro Trp Ser Ala Gly Lys Arg Asn Arg Lys Gly Glu Lys Asn 
            100                 105                 110         


Gly Lys Gly Leu Arg His Phe Ser Met Lys Val Cys Glu Lys Val Gln 
        115                 120                 125             


Arg Lys Gly Thr Thr Ser Tyr Asn Glu Val Ala Asp Glu Leu Val Ala 
    130                 135                 140                 


Glu Phe Ser Ala Ala Asp Asn His Ile Leu Pro Asn Glu Ser Ala Tyr 
145                 150                 155                 160 


Asp Gln Lys Asn Ile Arg Arg Arg Val Tyr Asp Ala Leu Asn Val Leu 
                165                 170                 175     


Met Ala Met Asn Ile Ile Ser Lys Glu Lys Lys Glu Ile Lys Trp Ile 
            180                 185                 190         


Gly Leu Pro Thr Asn Ser Ala Gln Glu Cys Gln Asn Leu Glu Val Glu 
        195                 200                 205             


Arg Gln Arg Arg Leu Glu Arg Ile Lys Gln Lys Gln Ser Gln Leu Gln 
    210                 215                 220                 


Glu Leu Ile Leu Gln Gln Ile Ala Phe Lys Asn Leu Val Gln Arg Asn 
225                 230                 235                 240 


Arg His Ala Glu Gln Gln Ala Ser Arg Pro Pro Pro Pro Asn Ser Val 
                245                 250                 255     


Ile His Leu Pro Phe Ile Ile Val Asn Thr Ser Lys Lys Thr Val Ile 
            260                 265                 270         


Asp Cys Ser Ile Ser Asn Asp Lys Phe Glu Tyr Leu Phe Asn Phe Asp 
        275                 280                 285             


Asn Thr Phe Glu Ile His Asp Asp Ile Glu Val Leu Lys Arg Met Gly 
    290                 295                 300                 


Met Ala Cys Gly Leu Glu Ser Gly Ser Cys Ser Ala Glu Asp Leu Lys 
305                 310                 315                 320 


Met Ala Arg Ser Leu Val Pro Lys Ala Leu Glu Pro Tyr Val Thr Glu 
                325                 330                 335     


Met Ala Gln Gly Thr Val Gly Gly Val Phe Ile Thr Thr Ala Gly Ser 
            340                 345                 350         


Thr Ser Asn Gly Thr Arg Phe Ser Ala Ser Asp Leu Thr Asn Gly Ala 
        355                 360                 365             


Asp Gly Met Leu Ala Thr Ser Ser Asn Gly Ser Gln Tyr Ser Gly Ser 
    370                 375                 380                 


Arg Val Glu Thr Pro Val Ser Tyr Val Gly Glu Asp Asp Glu Glu Asp 
385                 390                 395                 400 


Asp Asp Phe Asn Glu Asn Asp Glu Asp Asp 
                405                 410 


<210>  225
<211>  2275
<212>  PRT
<213>  homo sapiens

<400>  225

Met Ala Ala Glu Arg Arg Cys Gly Ser Met Arg Asp Leu Arg Ala Gln 
1               5                   10                  15      


Val Thr Ser Gly Leu Leu Pro Phe Pro Glu Val Thr Leu Gln Ala Leu 
            20                  25                  30          


Gly Glu Asp Glu Ile Thr Leu Glu Ser Val Leu Arg Gly Lys Phe Ala 
        35                  40                  45              


Ala Gly Lys Asn Gly Leu Ala Cys Leu Ala Cys Gly Pro Gln Leu Glu 
    50                  55                  60                  


Val Val Asn Ser Ile Thr Gly Glu Arg Leu Ser Ala Tyr Arg Phe Ser 
65                  70                  75                  80  


Gly Val Asn Glu Gln Pro Pro Val Val Leu Ala Val Lys Glu Phe Ser 
                85                  90                  95      


Trp Gln Lys Arg Thr Gly Leu Leu Ile Gly Leu Glu Glu Thr Glu Gly 
            100                 105                 110         


Ser Val Leu Cys Leu Tyr Asp Leu Gly Ile Ser Lys Val Val Lys Ala 
        115                 120                 125             


Val Val Leu Pro Gly Arg Val Thr Ala Ile Glu Pro Ile Ile Asn His 
    130                 135                 140                 


Gly Gly Ala Ser Ala Ser Thr Gln His Leu His Pro Ser Leu Arg Trp 
145                 150                 155                 160 


Leu Phe Gly Val Ala Ala Val Val Thr Asp Val Gly Gln Ile Leu Leu 
                165                 170                 175     


Val Asp Leu Cys Leu Asp Asp Leu Ser Cys Asn Gln Asn Glu Val Glu 
            180                 185                 190         


Ala Ser Asp Leu Glu Val Leu Thr Gly Ile Pro Ala Glu Val Pro His 
        195                 200                 205             


Ile Arg Glu Ser Val Met Arg Gln Gly Arg His Leu Cys Phe Gln Leu 
    210                 215                 220                 


Val Ser Pro Thr Gly Thr Ala Val Ser Thr Leu Ser Tyr Ile Ser Arg 
225                 230                 235                 240 


Thr Asn Gln Leu Ala Val Gly Phe Ser Asp Gly Tyr Leu Ala Leu Trp 
                245                 250                 255     


Asn Met Lys Ser Met Lys Arg Glu Tyr Tyr Ile Gln Leu Glu Ser Gly 
            260                 265                 270         


Gln Val Pro Val Tyr Ala Val Thr Phe Gln Glu Pro Glu Asn Asp Pro 
        275                 280                 285             


Arg Asn Cys Cys Tyr Leu Trp Ala Val Gln Ser Thr Gln Asp Ser Glu 
    290                 295                 300                 


Gly Asp Val Leu Ser Leu His Leu Leu Gln Leu Ala Phe Gly Asn Arg 
305                 310                 315                 320 


Lys Cys Leu Ala Ser Gly Gln Ile Leu Tyr Glu Gly Leu Glu Tyr Cys 
                325                 330                 335     


Glu Glu Arg Tyr Thr Leu Asp Leu Thr Gly Gly Met Phe Pro Leu Arg 
            340                 345                 350         


Gly Gln Thr Ser Asn Thr Lys Leu Leu Gly Cys Gln Ser Ile Glu Lys 
        355                 360                 365             


Phe Arg Ser His Gly Asp Arg Glu Glu Gly Val Asn Glu Ala Leu Ser 
    370                 375                 380                 


Pro Asp Thr Ser Val Ser Val Phe Thr Trp Gln Val Asn Ile Tyr Gly 
385                 390                 395                 400 


Gln Gly Lys Pro Ser Val Tyr Leu Gly Leu Phe Asp Ile Asn Arg Trp 
                405                 410                 415     


Tyr His Ala Gln Met Pro Asp Ser Leu Arg Ser Gly Glu Tyr Leu His 
            420                 425                 430         


Asn Cys Ser Tyr Phe Ala Leu Trp Ser Leu Glu Ser Val Val Ser Arg 
        435                 440                 445             


Thr Ser Pro His Gly Ile Leu Asp Ile Leu Val His Glu Arg Ser Leu 
    450                 455                 460                 


Asn Arg Gly Val Pro Pro Ser Tyr Pro Pro Pro Glu Gln Phe Phe Asn 
465                 470                 475                 480 


Pro Ser Thr Tyr Asn Phe Asp Ala Thr Cys Leu Leu Asn Ser Gly Val 
                485                 490                 495     


Val His Leu Thr Cys Thr Gly Phe Gln Lys Glu Thr Leu Thr Phe Leu 
            500                 505                 510         


Lys Lys Ser Gly Pro Ser Leu Asn Glu Leu Ile Pro Asp Gly Tyr Asn 
        515                 520                 525             


Arg Cys Leu Val Ala Gly Leu Leu Ser Pro Arg Phe Val Asp Val Gln 
    530                 535                 540                 


Pro Ser Ser Leu Ser Gln Glu Glu Gln Leu Glu Ala Ile Leu Ser Ala 
545                 550                 555                 560 


Ala Ile Gln Thr Ser Ser Leu Gly Leu Leu Thr Gly Tyr Ile Arg Arg 
                565                 570                 575     


Trp Ile Thr Glu Glu Gln Pro Asn Ser Ala Thr Asn Leu Arg Phe Val 
            580                 585                 590         


Leu Glu Trp Thr Trp Asn Lys Val Val Leu Thr Lys Glu Glu Phe Asp 
        595                 600                 605             


Arg Leu Cys Val Pro Leu Phe Asp Gly Ser Cys His Phe Met Asp Pro 
    610                 615                 620                 


Gln Thr Ile Gln Ser Ile Gln Gln Cys Tyr Leu Leu Leu Ser Asn Leu 
625                 630                 635                 640 


Asn Ile Val Leu Ser Cys Phe Ala Ser Glu Ala Arg Glu Ile Thr Glu 
                645                 650                 655     


Arg Gly Leu Ile Asp Leu Ser Asn Lys Phe Val Val Ser His Leu Ile 
            660                 665                 670         


Cys Gln Tyr Ala Gln Val Val Leu Trp Phe Ser His Ser Gly Leu Leu 
        675                 680                 685             


Pro Glu Gly Ile Asp Asp Ser Val Gln Leu Ser Arg Leu Cys Tyr Asn 
    690                 695                 700                 


Tyr Pro Val Ile Gln Asn Tyr Tyr Thr Ser Arg Arg Gln Lys Phe Glu 
705                 710                 715                 720 


Arg Leu Ser Arg Gly Lys Trp Asn Pro Asp Cys Leu Met Ile Asp Gly 
                725                 730                 735     


Leu Val Ser Gln Leu Gly Glu Arg Ile Glu Lys Leu Trp Lys Arg Asp 
            740                 745                 750         


Glu Gly Gly Thr Gly Lys Tyr Pro Pro Ala Ser Leu His Ala Val Leu 
        755                 760                 765             


Asp Met Tyr Leu Leu Asp Gly Val Thr Glu Ala Ala Lys His Ser Ile 
    770                 775                 780                 


Thr Ile Tyr Leu Leu Leu Asp Ile Met Tyr Ser Phe Pro Asn Lys Thr 
785                 790                 795                 800 


Asp Thr Pro Ile Glu Ser Phe Pro Thr Val Phe Ala Ile Ser Trp Gly 
                805                 810                 815     


Gln Val Lys Leu Ile Gln Gly Phe Trp Leu Ile Asp His Asn Asp Tyr 
            820                 825                 830         


Glu Ser Gly Leu Asp Leu Leu Phe His Pro Ala Thr Ala Lys Pro Leu 
        835                 840                 845             


Ser Trp Gln His Ser Lys Ile Ile Gln Ala Phe Met Ser Gln Gly Glu 
    850                 855                 860                 


His Arg Gln Ala Leu Arg Tyr Ile Gln Thr Met Lys Pro Thr Val Ser 
865                 870                 875                 880 


Ser Gly Asn Asp Val Ile Leu His Leu Thr Val Leu Leu Phe Asn Arg 
                885                 890                 895     


Cys Met Val Glu Ala Trp Asn Phe Leu Arg Gln His Cys Asn Arg Leu 
            900                 905                 910         


Asn Ile Glu Glu Leu Leu Lys His Met Tyr Glu Val Cys Gln Glu Met 
        915                 920                 925             


Gly Leu Met Glu Asp Leu Leu Lys Leu Pro Phe Thr Asp Thr Glu Gln 
    930                 935                 940                 


Glu Cys Leu Val Lys Phe Leu Gln Ser Ser Ala Ser Val Gln Asn His 
945                 950                 955                 960 


Glu Phe Leu Leu Val His His Leu Gln Arg Ala Asn Tyr Val Pro Ala 
                965                 970                 975     


Leu Lys Leu Asn Gln Thr Leu Lys Ile Asn Val Met Asn Asp Arg Asp 
            980                 985                 990         


Pro Arg Leu Arg Glu Arg Ser Leu  Ala Arg Asn Ser Ile  Leu Asp Gln 
        995                 1000                 1005             


Tyr Gly  Lys Ile Leu Pro Arg  Val His Arg Lys Leu  Ala Ile Glu 
    1010                 1015                 1020             


Arg Ala  Lys Pro Tyr His Leu  Ser Thr Ser Ser Val  Phe Arg Leu 
    1025                 1030                 1035             


Val Ser  Arg Pro Lys Pro Leu  Ser Ala Val Pro Lys  Gln Val Val 
    1040                 1045                 1050             


Thr Gly  Thr Val Leu Thr Arg  Ser Val Phe Ile Asn  Asn Val Leu 
    1055                 1060                 1065             


Ser Lys  Ile Gly Glu Val Trp  Ala Ser Lys Glu Pro  Ile Asn Ser 
    1070                 1075                 1080             


Thr Thr  Pro Phe Asn Ser Ser  Lys Ile Glu Glu Pro  Ser Pro Ile 
    1085                 1090                 1095             


Val Tyr  Ser Leu Pro Ala Pro  Glu Leu Pro Glu Ala  Phe Phe Gly 
    1100                 1105                 1110             


Thr Pro  Ile Ser Lys Ala Ser  Gln Lys Ile Ser Arg  Leu Leu Asp 
    1115                 1120                 1125             


Leu Val  Val Gln Pro Val Pro  Arg Pro Ser Gln Cys  Ser Glu Phe 
    1130                 1135                 1140             


Ile Gln  Gln Ser Ser Met Lys  Ser Pro Leu Tyr Leu  Val Ser Arg 
    1145                 1150                 1155             


Ser Leu  Pro Ser Ser Ser Gln  Leu Lys Gly Ser Pro  Gln Ala Ile 
    1160                 1165                 1170             


Ser Arg  Ala Ser Glu Leu His  Leu Leu Glu Thr Pro  Leu Val Val 
    1175                 1180                 1185             


Lys Lys  Ala Lys Ser Leu Ala  Met Ser Val Thr Thr  Ser Gly Phe 
    1190                 1195                 1200             


Ser Glu  Phe Thr Pro Gln Ser  Ile Leu Arg Ser Thr  Leu Arg Ser 
    1205                 1210                 1215             


Thr Pro  Leu Ala Ser Pro Ser  Pro Ser Pro Gly Arg  Ser Pro Gln 
    1220                 1225                 1230             


Arg Leu  Lys Glu Thr Arg Ile  Ser Phe Val Glu Glu  Asp Val His 
    1235                 1240                 1245             


Pro Lys  Trp Ile Pro Gly Ala  Ala Asp Asp Ser Lys  Leu Glu Val 
    1250                 1255                 1260             


Phe Thr  Thr Pro Lys Lys Cys  Ala Val Pro Val Glu  Thr Glu Trp 
    1265                 1270                 1275             


Leu Lys  Ser Lys Asp Arg Thr  Thr Ser Phe Phe Leu  Asn Ser Pro 
    1280                 1285                 1290             


Glu Lys  Glu His Gln Glu Met  Asp Glu Gly Ser Gln  Ser Leu Glu 
    1295                 1300                 1305             


Lys Leu  Asp Val Ser Lys Gly  Asn Ser Ser Val Ser  Ile Thr Ser 
    1310                 1315                 1320             


Asp Glu  Thr Thr Leu Glu Tyr  Gln Asp Ala Pro Ser  Pro Glu Asp 
    1325                 1330                 1335             


Leu Glu  Glu Thr Val Phe Thr  Ala Ser Lys Pro Lys  Ser Ser Ser 
    1340                 1345                 1350             


Thr Ala  Leu Thr Thr Asn Val  Thr Glu Gln Thr Glu  Lys Asp Gly 
    1355                 1360                 1365             


Asp Lys  Asp Val Phe Ala Ser  Glu Val Thr Pro Ser  Asp Leu Gln 
    1370                 1375                 1380             


Lys Gln  Met Gly Asn Leu Glu  Asp Ala Glu Thr Lys  Asp Leu Leu 
    1385                 1390                 1395             


Val Ala  Ala Glu Ala Phe Ser  Glu Leu Asn His Leu  Ser Pro Val 
    1400                 1405                 1410             


Gln Gly  Thr Glu Ala Ser Leu  Cys Ala Pro Ser Val  Tyr Glu Gly 
    1415                 1420                 1425             


Lys Ile  Phe Thr Gln Lys Ser  Lys Val Pro Val Leu  Asp Glu Gly 
    1430                 1435                 1440             


Leu Thr  Ser Val Glu Thr Tyr  Thr Pro Ala Ile Arg  Ala Asn Asp 
    1445                 1450                 1455             


Asn Lys  Ser Met Ala Asp Val  Leu Gly Asp Gly Gly  Asn Ser Ser 
    1460                 1465                 1470             


Leu Thr  Ile Ser Glu Gly Pro  Ile Val Ser Glu Arg  Arg Leu Asn 
    1475                 1480                 1485             


Gln Glu  Val Ala Leu Asn Leu  Lys Glu Asp His Glu  Val Glu Val 
    1490                 1495                 1500             


Gly Val  Leu Lys Glu Ser Val  Asp Leu Pro Glu Glu  Lys Leu Pro 
    1505                 1510                 1515             


Ile Ser  Asp Ser Pro Pro Asp  Thr Gln Glu Ile His  Val Ile Glu 
    1520                 1525                 1530             


Gln Glu  Lys Leu Glu Ala Gln  Asp Ser Gly Glu Glu  Ala Arg Asn 
    1535                 1540                 1545             


Leu Ser  Phe Asn Glu Leu Tyr  Pro Ser Gly Thr Leu  Lys Leu Gln 
    1550                 1555                 1560             


Tyr Asn  Phe Asp Thr Ile Asp  Gln Gln Phe Cys Asp  Leu Ala Asp 
    1565                 1570                 1575             


Asn Lys  Asp Thr Ala Glu Cys  Asp Ile Ala Glu Val  Asp Gly Glu 
    1580                 1585                 1590             


Leu Phe  Val Ala Gln Ser Asn  Phe Thr Leu Ile Leu  Glu Gly Glu 
    1595                 1600                 1605             


Glu Gly  Glu Val Glu Pro Gly  Asp Phe Ala Ser Ser  Asp Val Leu 
    1610                 1615                 1620             


Pro Lys  Ala Ala Asn Thr Ala  Thr Glu Glu Lys Leu  Val Cys Ser 
    1625                 1630                 1635             


Gly Glu  Asn Asp Asn His Gly  Gln Ile Ala Asn Leu  Pro Ser Ala 
    1640                 1645                 1650             


Val Thr  Ser Asp Gln Lys Ser  Gln Lys Val Asp Thr  Leu Pro Tyr 
    1655                 1660                 1665             


Val Pro  Glu Pro Ile Lys Val  Ala Ile Ala Glu Asn  Leu Leu Asp 
    1670                 1675                 1680             


Val Ile  Lys Asp Thr Arg Ser  Lys Glu Ile Thr Ser  Asp Thr Met 
    1685                 1690                 1695             


Glu Gln  Ser Ile His Glu Thr  Ile Pro Leu Val Ser  Gln Asn Ile 
    1700                 1705                 1710             


Met Cys  Pro Thr Lys Leu Val  Lys Ser Ala Phe Lys  Thr Ala Gln 
    1715                 1720                 1725             


Glu Thr  Ser Thr Met Thr Met  Asn Val Ser Gln Val  Asp Asp Val 
    1730                 1735                 1740             


Val Ser  Ser Lys Thr Arg Thr  Arg Gly Gln Arg Ile  Gln Asn Val 
    1745                 1750                 1755             


Asn Val  Lys Ser Ala Gln Gln  Glu Ala Ser Ala Asp  Val Ala Thr 
    1760                 1765                 1770             


Pro Lys  Met Pro Gly Gln Ser  Val Arg Lys Lys Thr  Arg Lys Ala 
    1775                 1780                 1785             


Lys Glu  Ile Ser Glu Ala Ser  Glu Asn Ile Tyr Ser  Asp Val Arg 
    1790                 1795                 1800             


Gly Leu  Ser Gln Asn Gln Gln  Ile Pro Gln Asn Ser  Val Thr Pro 
    1805                 1810                 1815             


Arg Arg  Gly Arg Arg Lys Lys  Glu Val Asn Gln Asp  Ile Leu Glu 
    1820                 1825                 1830             


Asn Thr  Ser Ser Val Glu Gln  Glu Leu Gln Ile Thr  Thr Gly Arg 
    1835                 1840                 1845             


Glu Ser  Lys Arg Leu Lys Ser  Ser Gln Leu Leu Glu  Pro Ala Val 
    1850                 1855                 1860             


Glu Glu  Thr Thr Lys Lys Glu  Val Lys Val Ser Ser  Val Thr Lys 
    1865                 1870                 1875             


Arg Thr  Pro Arg Arg Ile Lys  Arg Ser Val Glu Asn  Gln Glu Ser 
    1880                 1885                 1890             


Val Glu  Ile Ile Asn Asp Leu  Lys Val Ser Thr Val  Thr Ser Pro 
    1895                 1900                 1905             


Ser Arg  Met Ile Arg Lys Leu  Arg Ser Thr Asn Leu  Asp Ala Ser 
    1910                 1915                 1920             


Glu Asn  Thr Gly Asn Lys Gln  Asp Asp Lys Ser Ser  Asp Lys Gln 
    1925                 1930                 1935             


Leu Arg  Ile Lys His Val Arg  Arg Val Arg Gly Arg  Glu Val Ser 
    1940                 1945                 1950             


Pro Ser  Asp Val Arg Glu Asp  Ser Asn Leu Glu Ser  Ser Gln Leu 
    1955                 1960                 1965             


Thr Val  Gln Ala Glu Phe Asp  Met Ser Ala Ile Pro  Arg Lys Arg 
    1970                 1975                 1980             


Gly Arg  Pro Arg Lys Ile Asn  Pro Ser Glu Asp Val  Gly Ser Lys 
    1985                 1990                 1995             


Ala Val  Lys Glu Glu Arg Ser  Pro Lys Lys Lys Glu  Ala Pro Ser 
    2000                 2005                 2010             


Ile Arg  Arg Arg Ser Thr Arg  Asn Thr Pro Ala Lys  Ser Glu Asn 
    2015                 2020                 2025             


Val Asp  Val Gly Lys Pro Ala  Leu Gly Lys Ser Ile  Leu Val Pro 
    2030                 2035                 2040             


Asn Glu  Glu Leu Ser Met Val  Met Ser Ser Lys Lys  Lys Leu Thr 
    2045                 2050                 2055             


Lys Lys  Thr Glu Ser Gln Ser  Gln Lys Arg Ser Leu  His Ser Val 
    2060                 2065                 2070             


Ser Glu  Glu Arg Thr Asp Glu  Met Thr His Lys Glu  Thr Asn Glu 
    2075                 2080                 2085             


Gln Glu  Glu Arg Leu Leu Ala  Thr Ala Ser Phe Thr  Lys Ser Ser 
    2090                 2095                 2100             


Arg Ser  Ser Arg Thr Arg Ser  Ser Lys Ala Ile Leu  Leu Pro Asp 
    2105                 2110                 2115             


Leu Ser  Glu Pro Asn Asn Glu  Pro Leu Phe Ser Pro  Ala Ser Glu 
    2120                 2125                 2130             


Val Pro  Arg Lys Ala Lys Ala  Lys Lys Ile Glu Val  Pro Ala Gln 
    2135                 2140                 2145             


Leu Lys  Glu Leu Val Ser Asp  Leu Ser Ser Gln Phe  Val Ile Ser 
    2150                 2155                 2160             


Pro Pro  Ala Leu Arg Ser Arg  Gln Lys Asn Thr Ser  Asn Lys Asn 
    2165                 2170                 2175             


Lys Leu  Glu Asp Glu Leu Lys  Asp Asp Ala Gln Ser  Val Glu Thr 
    2180                 2185                 2190             


Leu Gly  Lys Pro Lys Ala Lys  Arg Ile Arg Thr Ser  Lys Thr Lys 
    2195                 2200                 2205             


Gln Ala  Ser Lys Asn Thr Glu  Lys Glu Ser Ala Trp  Ser Pro Pro 
    2210                 2215                 2220             


Pro Ile  Glu Ile Arg Leu Ile  Ser Pro Leu Ala Ser  Pro Ala Asp 
    2225                 2230                 2235             


Gly Val  Lys Ser Lys Pro Arg  Lys Thr Thr Glu Val  Thr Gly Thr 
    2240                 2245                 2250             


Gly Leu  Gly Arg Asn Arg Lys  Lys Leu Ser Ser Tyr  Pro Lys Gln 
    2255                 2260                 2265             


Ile Leu  Arg Arg Lys Met Leu  
    2270                 2275 


<210>  226
<211>  1872
<212>  PRT
<213>  homo sapiens

<400>  226

Met Gly Pro Gly Cys Asp Leu Leu Leu Arg Thr Ala Ala Thr Ile Thr 
1               5                   10                  15      


Ala Ala Ala Ile Met Ser Asp Thr Asp Ser Asp Glu Asp Ser Ala Gly 
            20                  25                  30          


Gly Gly Pro Phe Ser Leu Ala Gly Phe Leu Phe Gly Asn Ile Asn Gly 
        35                  40                  45              


Ala Gly Gln Leu Glu Gly Glu Ser Val Leu Asp Asp Glu Cys Lys Lys 
    50                  55                  60                  


His Leu Ala Gly Leu Gly Ala Leu Gly Leu Gly Ser Leu Ile Thr Glu 
65                  70                  75                  80  


Leu Thr Ala Asn Glu Glu Leu Thr Gly Thr Asp Gly Ala Leu Val Asn 
                85                  90                  95      


Asp Glu Gly Trp Val Arg Ser Thr Glu Asp Ala Val Asp Tyr Ser Asp 
            100                 105                 110         


Ile Asn Glu Val Ala Glu Asp Glu Ser Arg Arg Tyr Gln Gln Thr Met 
        115                 120                 125             


Gly Ser Leu Gln Pro Leu Cys His Ser Asp Tyr Asp Glu Asp Asp Tyr 
    130                 135                 140                 


Asp Ala Asp Cys Glu Asp Ile Asp Cys Lys Leu Met Pro Pro Pro Pro 
145                 150                 155                 160 


Pro Pro Pro Gly Pro Met Lys Lys Asp Lys Asp Gln Asp Ser Ile Thr 
                165                 170                 175     


Gly Glu Lys Val Asp Phe Ser Ser Ser Ser Asp Ser Glu Ser Glu Met 
            180                 185                 190         


Gly Pro Gln Glu Ala Thr Gln Ala Glu Ser Glu Asp Gly Lys Leu Thr 
        195                 200                 205             


Leu Pro Leu Ala Gly Ile Met Gln His Asp Ala Thr Lys Leu Leu Pro 
    210                 215                 220                 


Ser Val Thr Glu Leu Phe Pro Glu Phe Arg Pro Gly Lys Val Leu Arg 
225                 230                 235                 240 


Phe Leu Arg Leu Phe Gly Pro Gly Lys Asn Val Pro Ser Val Trp Arg 
                245                 250                 255     


Ser Ala Arg Arg Lys Arg Lys Lys Lys His Arg Glu Leu Ile Gln Glu 
            260                 265                 270         


Glu Gln Ile Gln Glu Val Glu Cys Ser Val Glu Ser Glu Val Ser Gln 
        275                 280                 285             


Lys Ser Leu Trp Asn Tyr Asp Tyr Ala Pro Pro Pro Pro Pro Glu Gln 
    290                 295                 300                 


Cys Leu Ser Asp Asp Glu Ile Thr Met Met Ala Pro Val Glu Ser Lys 
305                 310                 315                 320 


Phe Ser Gln Ser Thr Gly Asp Ile Asp Lys Val Thr Asp Thr Lys Pro 
                325                 330                 335     


Arg Val Ala Glu Trp Arg Tyr Gly Pro Ala Arg Leu Trp Tyr Asp Met 
            340                 345                 350         


Leu Gly Val Pro Glu Asp Gly Ser Gly Phe Asp Tyr Gly Phe Lys Leu 
        355                 360                 365             


Arg Lys Thr Glu His Glu Pro Val Ile Lys Ser Arg Met Ile Glu Glu 
    370                 375                 380                 


Phe Arg Lys Leu Glu Glu Asn Asn Gly Thr Asp Leu Leu Ala Asp Glu 
385                 390                 395                 400 


Asn Phe Leu Met Val Thr Gln Leu His Trp Glu Asp Asp Ile Ile Trp 
                405                 410                 415     


Asp Gly Glu Asp Val Lys His Lys Gly Thr Lys Pro Gln Arg Ala Ser 
            420                 425                 430         


Leu Ala Gly Trp Leu Pro Ser Ser Met Thr Arg Asn Ala Met Ala Tyr 
        435                 440                 445             


Asn Val Gln Gln Gly Phe Ala Ala Thr Leu Asp Asp Asp Lys Pro Trp 
    450                 455                 460                 


Tyr Ser Ile Phe Pro Ile Asp Asn Glu Asp Leu Val Tyr Gly Arg Trp 
465                 470                 475                 480 


Glu Asp Asn Ile Ile Trp Asp Ala Gln Ala Met Pro Arg Leu Leu Glu 
                485                 490                 495     


Pro Pro Val Leu Thr Leu Asp Pro Asn Asp Glu Asn Leu Ile Leu Glu 
            500                 505                 510         


Ile Pro Asp Glu Lys Glu Glu Ala Thr Ser Asn Ser Pro Ser Lys Glu 
        515                 520                 525             


Ser Lys Lys Glu Ser Ser Leu Lys Lys Ser Arg Ile Leu Leu Gly Lys 
    530                 535                 540                 


Thr Gly Val Ile Lys Glu Glu Pro Gln Gln Asn Met Ser Gln Pro Glu 
545                 550                 555                 560 


Val Lys Asp Pro Trp Asn Leu Ser Asn Asp Glu Tyr Tyr Tyr Pro Lys 
                565                 570                 575     


Gln Gln Gly Leu Arg Gly Thr Phe Gly Gly Asn Ile Ile Gln His Ser 
            580                 585                 590         


Ile Pro Ala Val Glu Leu Arg Gln Pro Phe Phe Pro Thr His Met Gly 
        595                 600                 605             


Pro Ile Lys Leu Arg Gln Phe His Arg Pro Pro Leu Lys Lys Tyr Ser 
    610                 615                 620                 


Phe Gly Ala Leu Ser Gln Pro Gly Pro His Ser Val Gln Pro Leu Leu 
625                 630                 635                 640 


Lys His Ile Lys Lys Lys Ala Lys Met Arg Glu Gln Glu Arg Gln Ala 
                645                 650                 655     


Ser Gly Gly Gly Glu Met Phe Phe Met Arg Thr Pro Gln Asp Leu Thr 
            660                 665                 670         


Gly Lys Asp Gly Asp Leu Ile Leu Ala Glu Tyr Ser Glu Glu Asn Gly 
        675                 680                 685             


Pro Leu Met Met Gln Val Gly Met Ala Thr Lys Ile Lys Asn Tyr Tyr 
    690                 695                 700                 


Lys Arg Lys Pro Gly Lys Asp Pro Gly Ala Pro Asp Cys Lys Tyr Gly 
705                 710                 715                 720 


Glu Thr Val Tyr Cys His Thr Ser Pro Phe Leu Gly Ser Leu His Pro 
                725                 730                 735     


Gly Gln Leu Leu Gln Ala Phe Glu Asn Asn Leu Phe Arg Ala Pro Ile 
            740                 745                 750         


Tyr Leu His Lys Met Pro Glu Thr Asp Phe Leu Ile Ile Arg Thr Arg 
        755                 760                 765             


Gln Gly Tyr Tyr Ile Arg Glu Leu Val Asp Ile Phe Val Val Gly Gln 
    770                 775                 780                 


Gln Cys Pro Leu Phe Glu Val Pro Gly Pro Asn Ser Lys Arg Ala Asn 
785                 790                 795                 800 


Thr His Ile Arg Asp Phe Leu Gln Val Phe Ile Tyr Arg Leu Phe Trp 
                805                 810                 815     


Lys Ser Lys Asp Arg Pro Arg Arg Ile Arg Met Glu Asp Ile Lys Lys 
            820                 825                 830         


Ala Phe Pro Ser His Ser Glu Ser Ser Ile Arg Lys Arg Leu Lys Leu 
        835                 840                 845             


Cys Ala Asp Phe Lys Arg Thr Gly Met Asp Ser Asn Trp Trp Val Leu 
    850                 855                 860                 


Lys Ser Asp Phe Arg Leu Pro Thr Glu Glu Glu Ile Arg Ala Met Val 
865                 870                 875                 880 


Ser Pro Glu Gln Cys Cys Ala Tyr Tyr Ser Met Ile Ala Ala Glu Gln 
                885                 890                 895     


Arg Leu Lys Asp Ala Gly Tyr Gly Glu Lys Ser Phe Phe Ala Pro Glu 
            900                 905                 910         


Glu Glu Asn Glu Glu Asp Phe Gln Met Lys Ile Asp Asp Glu Val Arg 
        915                 920                 925             


Thr Ala Pro Trp Asn Thr Thr Arg Ala Phe Ile Ala Ala Met Lys Gly 
    930                 935                 940                 


Lys Cys Leu Leu Glu Val Thr Gly Val Ala Asp Pro Thr Gly Cys Gly 
945                 950                 955                 960 


Glu Gly Phe Ser Tyr Val Lys Ile Pro Asn Lys Pro Thr Gln Gln Lys 
                965                 970                 975     


Asp Asp Lys Glu Pro Gln Pro Val Lys Lys Thr Val Thr Gly Thr Asp 
            980                 985                 990         


Ala Asp Leu Arg Arg Leu Ser Leu  Lys Asn Ala Lys Gln  Leu Leu Arg 
        995                 1000                 1005             


Lys Phe  Gly Val Pro Glu Glu  Glu Ile Lys Lys Leu  Ser Arg Trp 
    1010                 1015                 1020             


Glu Val  Ile Asp Val Val Arg  Thr Met Ser Thr Glu  Gln Ala Arg 
    1025                 1030                 1035             


Ser Gly  Glu Gly Pro Met Ser  Lys Phe Ala Arg Gly  Ser Arg Phe 
    1040                 1045                 1050             


Ser Val  Ala Glu His Gln Glu  Arg Tyr Lys Glu Glu  Cys Gln Arg 
    1055                 1060                 1065             


Ile Phe  Asp Leu Gln Asn Lys  Val Leu Ser Ser Thr  Glu Val Leu 
    1070                 1075                 1080             


Ser Thr  Asp Thr Asp Ser Ser  Ser Ala Glu Asp Ser  Asp Phe Glu 
    1085                 1090                 1095             


Glu Met  Gly Lys Asn Ile Glu  Asn Met Leu Gln Asn  Lys Lys Thr 
    1100                 1105                 1110             


Ser Ser  Gln Leu Ser Arg Glu  Arg Glu Glu Gln Glu  Arg Lys Glu 
    1115                 1120                 1125             


Leu Gln  Arg Met Leu Leu Ala  Ala Gly Ser Ala Ala  Ser Gly Asn 
    1130                 1135                 1140             


Asn His  Arg Asp Asp Asp Thr  Ala Ser Val Thr Ser  Leu Asn Ser 
    1145                 1150                 1155             


Ser Ala  Thr Gly Arg Cys Leu  Lys Ile Tyr Arg Thr  Phe Arg Asp 
    1160                 1165                 1170             


Glu Glu  Gly Lys Glu Tyr Val  Arg Cys Glu Thr Val  Arg Lys Pro 
    1175                 1180                 1185             


Ala Val  Ile Asp Ala Tyr Val  Arg Ile Arg Thr Thr  Lys Asp Glu 
    1190                 1195                 1200             


Glu Phe  Ile Arg Lys Phe Ala  Leu Phe Asp Glu Gln  His Arg Glu 
    1205                 1210                 1215             


Glu Met  Arg Lys Glu Arg Arg  Arg Ile Gln Glu Gln  Leu Arg Arg 
    1220                 1225                 1230             


Leu Lys  Arg Asn Gln Glu Lys  Glu Lys Leu Lys Gly  Pro Pro Glu 
    1235                 1240                 1245             


Lys Lys  Pro Lys Lys Met Lys  Glu Arg Pro Asp Leu  Lys Leu Lys 
    1250                 1255                 1260             


Cys Gly  Ala Cys Gly Ala Ile  Gly His Met Arg Thr  Asn Lys Phe 
    1265                 1270                 1275             


Cys Pro  Leu Tyr Tyr Gln Thr  Asn Ala Pro Pro Ser  Asn Pro Val 
    1280                 1285                 1290             


Ala Met  Thr Glu Glu Gln Glu  Glu Glu Leu Glu Lys  Thr Val Ile 
    1295                 1300                 1305             


His Asn  Asp Asn Glu Glu Leu  Ile Lys Val Glu Gly  Thr Lys Ile 
    1310                 1315                 1320             


Val Leu  Gly Lys Gln Leu Ile  Glu Ser Ala Asp Glu  Val Arg Arg 
    1325                 1330                 1335             


Lys Ser  Leu Val Leu Lys Phe  Pro Lys Gln Gln Leu  Pro Pro Lys 
    1340                 1345                 1350             


Lys Lys  Arg Arg Val Gly Thr  Thr Val His Cys Asp  Tyr Leu Asn 
    1355                 1360                 1365             


Arg Pro  His Lys Ser Ile His  Arg Arg Arg Thr Asp  Pro Met Val 
    1370                 1375                 1380             


Thr Leu  Ser Ser Ile Leu Glu  Ser Ile Ile Asn Asp  Met Arg Asp 
    1385                 1390                 1395             


Leu Pro  Asn Thr Tyr Pro Phe  His Thr Pro Val Asn  Ala Lys Val 
    1400                 1405                 1410             


Val Lys  Asp Tyr Tyr Lys Ile  Ile Thr Arg Pro Met  Asp Leu Gln 
    1415                 1420                 1425             


Thr Leu  Arg Glu Asn Val Arg  Lys Arg Leu Tyr Pro  Ser Arg Glu 
    1430                 1435                 1440             


Glu Phe  Arg Glu His Leu Glu  Leu Ile Val Lys Asn  Ser Ala Thr 
    1445                 1450                 1455             


Tyr Asn  Gly Pro Lys His Ser  Leu Thr Gln Ile Ser  Gln Ser Met 
    1460                 1465                 1470             


Leu Asp  Leu Cys Asp Glu Lys  Leu Lys Glu Lys Glu  Asp Lys Leu 
    1475                 1480                 1485             


Ala Arg  Leu Glu Lys Ala Ile  Asn Pro Leu Leu Asp  Asp Asp Asp 
    1490                 1495                 1500             


Gln Val  Ala Phe Ser Phe Ile  Leu Asp Asn Ile Val  Thr Gln Lys 
    1505                 1510                 1515             


Met Met  Ala Val Pro Asp Ser  Trp Pro Phe His His  Pro Val Asn 
    1520                 1525                 1530             


Lys Lys  Phe Val Pro Asp Tyr  Tyr Lys Val Ile Val  Asn Pro Met 
    1535                 1540                 1545             


Asp Leu  Glu Thr Ile Arg Lys  Asn Ile Ser Lys His  Lys Tyr Gln 
    1550                 1555                 1560             


Ser Arg  Glu Ser Phe Leu Asp  Asp Val Asn Leu Ile  Leu Ala Asn 
    1565                 1570                 1575             


Ser Val  Lys Tyr Asn Gly Pro  Glu Ser Gln Tyr Thr  Lys Thr Ala 
    1580                 1585                 1590             


Gln Glu  Ile Val Asn Val Cys  Tyr Gln Thr Leu Thr  Glu Tyr Asp 
    1595                 1600                 1605             


Glu His  Leu Thr Gln Leu Glu  Lys Asp Ile Cys Thr  Ala Lys Glu 
    1610                 1615                 1620             


Ala Ala  Leu Glu Glu Ala Glu  Leu Glu Ser Leu Asp  Pro Met Thr 
    1625                 1630                 1635             


Pro Gly  Pro Tyr Thr Pro Gln  Pro Pro Asp Leu Tyr  Asp Thr Asn 
    1640                 1645                 1650             


Thr Ser  Leu Ser Met Ser Arg  Asp Ala Ser Val Phe  Gln Asp Glu 
    1655                 1660                 1665             


Ser Asn  Met Ser Val Leu Asp  Ile Pro Ser Ala Thr  Pro Glu Lys 
    1670                 1675                 1680             


Gln Val  Thr Gln Glu Gly Glu  Asp Gly Asp Gly Asp  Leu Ala Asp 
    1685                 1690                 1695             


Glu Glu  Glu Gly Thr Val Gln  Gln Pro Gln Ala Ser  Val Leu Tyr 
    1700                 1705                 1710             


Glu Asp  Leu Leu Met Ser Glu  Gly Glu Asp Asp Glu  Glu Asp Ala 
    1715                 1720                 1725             


Gly Ser  Asp Glu Glu Gly Asp  Asn Pro Phe Ser Ala  Ile Gln Leu 
    1730                 1735                 1740             


Ser Glu  Ser Gly Ser Asp Ser  Asp Val Gly Ser Gly  Gly Ile Arg 
    1745                 1750                 1755             


Pro Lys  Gln Pro Arg Met Leu  Gln Glu Asn Thr Arg  Met Asp Met 
    1760                 1765                 1770             


Glu Asn  Glu Glu Ser Met Met  Ser Tyr Glu Gly Asp  Gly Gly Glu 
    1775                 1780                 1785             


Ala Ser  His Gly Leu Glu Asp  Ser Asn Ile Ser Tyr  Gly Ser Tyr 
    1790                 1795                 1800             


Glu Glu  Pro Asp Pro Lys Ser  Asn Thr Gln Asp Thr  Ser Phe Ser 
    1805                 1810                 1815             


Ser Ile  Gly Gly Tyr Glu Val  Ser Glu Glu Glu Glu  Asp Glu Glu 
    1820                 1825                 1830             


Glu Glu  Glu Gln Arg Ser Gly  Pro Ser Val Leu Ser  Gln Val His 
    1835                 1840                 1845             


Leu Ser  Glu Asp Glu Glu Asp  Ser Glu Asp Phe His  Ser Ile Ala 
    1850                 1855                 1860             


Gly Asp  Ser Asp Leu Asp Ser  Asp Glu 
    1865                 1870         


<210>  227
<211>  727
<212>  PRT
<213>  homo sapiens

<400>  227

Met Glu Gly Asp Ala Val Glu Ala Ile Val Glu Glu Ser Glu Thr Phe 
1               5                   10                  15      


Ile Lys Gly Lys Glu Arg Lys Thr Tyr Gln Arg Arg Arg Glu Gly Gly 
            20                  25                  30          


Gln Glu Glu Asp Ala Cys His Leu Pro Gln Asn Gln Thr Asp Gly Gly 
        35                  40                  45              


Glu Val Val Gln Asp Val Asn Ser Ser Val Gln Met Val Met Met Glu 
    50                  55                  60                  


Gln Leu Asp Pro Thr Leu Leu Gln Met Lys Thr Glu Val Met Glu Gly 
65                  70                  75                  80  


Thr Val Ala Pro Glu Ala Glu Ala Ala Val Asp Asp Thr Gln Ile Ile 
                85                  90                  95      


Thr Leu Gln Val Val Asn Met Glu Glu Gln Pro Ile Asn Ile Gly Glu 
            100                 105                 110         


Leu Gln Leu Val Gln Val Pro Val Pro Val Thr Val Pro Val Ala Thr 
        115                 120                 125             


Thr Ser Val Glu Glu Leu Gln Gly Ala Tyr Glu Asn Glu Val Ser Lys 
    130                 135                 140                 


Glu Gly Leu Ala Glu Ser Glu Pro Met Ile Cys His Thr Leu Pro Leu 
145                 150                 155                 160 


Pro Glu Gly Phe Gln Val Val Lys Val Gly Ala Asn Gly Glu Val Glu 
                165                 170                 175     


Thr Leu Glu Gln Gly Glu Leu Pro Pro Gln Glu Asp Pro Ser Trp Gln 
            180                 185                 190         


Lys Asp Pro Asp Tyr Gln Pro Pro Ala Lys Lys Thr Lys Lys Thr Lys 
        195                 200                 205             


Lys Ser Lys Leu Arg Tyr Thr Glu Glu Gly Lys Asp Val Asp Val Ser 
    210                 215                 220                 


Val Tyr Asp Phe Glu Glu Glu Gln Gln Glu Gly Leu Leu Ser Glu Val 
225                 230                 235                 240 


Asn Ala Glu Lys Val Val Gly Asn Met Lys Pro Pro Lys Pro Thr Lys 
                245                 250                 255     


Ile Lys Lys Lys Gly Val Lys Lys Thr Phe Gln Cys Glu Leu Cys Ser 
            260                 265                 270         


Tyr Thr Cys Pro Arg Arg Ser Asn Leu Asp Arg His Met Lys Ser His 
        275                 280                 285             


Thr Asp Glu Arg Pro His Lys Cys His Leu Cys Gly Arg Ala Phe Arg 
    290                 295                 300                 


Thr Val Thr Leu Leu Arg Asn His Leu Asn Thr His Thr Gly Thr Arg 
305                 310                 315                 320 


Pro His Lys Cys Pro Asp Cys Asp Met Ala Phe Val Thr Ser Gly Glu 
                325                 330                 335     


Leu Val Arg His Arg Arg Tyr Lys His Thr His Glu Lys Pro Phe Lys 
            340                 345                 350         


Cys Ser Met Cys Asp Tyr Ala Ser Val Glu Val Ser Lys Leu Lys Arg 
        355                 360                 365             


His Ile Arg Ser His Thr Gly Glu Arg Pro Phe Gln Cys Ser Leu Cys 
    370                 375                 380                 


Ser Tyr Ala Ser Arg Asp Thr Tyr Lys Leu Lys Arg His Met Arg Thr 
385                 390                 395                 400 


His Ser Gly Glu Lys Pro Tyr Glu Cys Tyr Ile Cys His Ala Arg Phe 
                405                 410                 415     


Thr Gln Ser Gly Thr Met Lys Met His Ile Leu Gln Lys His Thr Glu 
            420                 425                 430         


Asn Val Ala Lys Phe His Cys Pro His Cys Asp Thr Val Ile Ala Arg 
        435                 440                 445             


Lys Ser Asp Leu Gly Val His Leu Arg Lys Gln His Ser Tyr Ile Glu 
    450                 455                 460                 


Gln Gly Lys Lys Cys Arg Tyr Cys Asp Ala Val Phe His Glu Arg Tyr 
465                 470                 475                 480 


Ala Leu Ile Gln His Gln Lys Ser His Lys Asn Glu Lys Arg Phe Lys 
                485                 490                 495     


Cys Asp Gln Cys Asp Tyr Ala Cys Arg Gln Glu Arg His Met Ile Met 
            500                 505                 510         


His Lys Arg Thr His Thr Gly Glu Lys Pro Tyr Ala Cys Ser His Cys 
        515                 520                 525             


Asp Lys Thr Phe Arg Gln Lys Gln Leu Leu Asp Met His Phe Lys Arg 
    530                 535                 540                 


Tyr His Asp Pro Asn Phe Val Pro Ala Ala Phe Val Cys Ser Lys Cys 
545                 550                 555                 560 


Gly Lys Thr Phe Thr Arg Arg Asn Thr Met Ala Arg His Ala Asp Asn 
                565                 570                 575     


Cys Ala Gly Pro Asp Gly Val Glu Gly Glu Asn Gly Gly Glu Thr Lys 
            580                 585                 590         


Lys Ser Lys Arg Gly Arg Lys Arg Lys Met Arg Ser Lys Lys Glu Asp 
        595                 600                 605             


Ser Ser Asp Ser Glu Asn Ala Glu Pro Asp Leu Asp Asp Asn Glu Asp 
    610                 615                 620                 


Glu Glu Glu Pro Ala Val Glu Ile Glu Pro Glu Pro Glu Pro Gln Pro 
625                 630                 635                 640 


Val Thr Pro Ala Pro Pro Pro Ala Lys Lys Arg Arg Gly Arg Pro Pro 
                645                 650                 655     


Gly Arg Thr Asn Gln Pro Lys Gln Asn Gln Pro Thr Ala Ile Ile Gln 
            660                 665                 670         


Val Glu Asp Gln Asn Thr Gly Ala Ile Glu Asn Ile Ile Val Glu Val 
        675                 680                 685             


Lys Lys Glu Pro Asp Ala Glu Pro Ala Glu Gly Glu Glu Glu Glu Ala 
    690                 695                 700                 


Gln Pro Ala Ala Thr Asp Ala Pro Asn Gly Asp Leu Thr Pro Glu Met 
705                 710                 715                 720 


Ile Leu Ser Met Met Asp Arg 
                725         


<210>  228
<211>  1182
<212>  PRT
<213>  homo sapiens

<400>  228

Met Gly Gln Gln Val Gly Arg Val Gly Glu Ala Pro Gly Leu Gln Gln 
1               5                   10                  15      


Pro Gln Pro Arg Gly Ile Arg Gly Ser Ser Ala Ala Arg Pro Ser Gly 
            20                  25                  30          


Arg Arg Arg Asp Pro Ala Gly Arg Thr Thr Glu Thr Gly Phe Asn Ile 
        35                  40                  45              


Phe Thr Gln His Asp His Phe Ala Ser Cys Val Glu Asp Gly Phe Glu 
    50                  55                  60                  


Gly Asp Lys Thr Gly Gly Ser Ser Pro Glu Ala Leu His Arg Pro Tyr 
65                  70                  75                  80  


Gly Cys Asp Val Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser 
                85                  90                  95      


Ser Lys Glu Asn Leu Leu Gly Ala Thr Glu Ser Asp Pro Asn Leu Phe 
            100                 105                 110         


Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile 
        115                 120                 125             


Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu 
    130                 135                 140                 


Trp Ser Glu Val Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn 
145                 150                 155                 160 


Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly 
                165                 170                 175     


Pro Val Ser Arg Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn 
            180                 185                 190         


Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser 
        195                 200                 205             


Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Thr 
    210                 215                 220                 


Thr Ala Asp Gly Lys Val Tyr Val Thr Ala Glu Ser Arg Phe Ser Thr 
225                 230                 235                 240 


Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly Leu Val 
                245                 250                 255     


Thr Thr Leu His Tyr Pro Ala Pro Lys Cys Asn Lys Pro Thr Val Tyr 
            260                 265                 270         


Gly Val Ser Pro Ile His Asp Lys Trp Glu Met Glu Arg Thr Asp Ile 
        275                 280                 285             


Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val 
    290                 295                 300                 


Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr Leu Lys 
305                 310                 315                 320 


Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met 
                325                 330                 335     


Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Thr 
            340                 345                 350         


Leu Glu Pro Pro Phe Tyr Ile Val Thr Glu Tyr Met Pro Tyr Gly Asn 
        355                 360                 365             


Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Glu Glu Val Thr Ala Val 
    370                 375                 380                 


Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr Leu 
385                 390                 395                 400 


Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
                405                 410                 415     


Val Gly Glu Asn His Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg 
            420                 425                 430         


Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys Phe Pro 
        435                 440                 445             


Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Thr Phe Ser Ile 
    450                 455                 460                 


Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Thr 
465                 470                 475                 480 


Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp 
                485                 490                 495     


Leu Leu Glu Lys Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro 
            500                 505                 510         


Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp 
        515                 520                 525             


Arg Pro Ser Phe Ala Glu Thr His Gln Ala Phe Glu Thr Met Phe His 
    530                 535                 540                 


Asp Ser Ser Ile Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala 
545                 550                 555                 560 


Ser Ser Ser Ser Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro 
                565                 570                 575     


Ser Lys Thr Arg Thr Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile 
            580                 585                 590         


Glu Gly Ala Gln Asp Ala Thr Glu Asn Ser Ala Ser Ser Leu Ala Pro 
        595                 600                 605             


Gly Phe Ile Arg Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro 
    610                 615                 620                 


Arg Lys Gln Arg Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys 
625                 630                 635                 640 


Glu Thr Cys Phe Thr Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe 
                645                 650                 655     


Met Lys Lys Arg Asn Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe 
            660                 665                 670         


Arg Glu Met Glu Asn Gln Pro His Lys Lys Tyr Glu Leu Thr Gly Asn 
        675                 680                 685             


Phe Ser Ser Val Ala Ser Leu Gln His Ala Asp Gly Phe Ser Phe Thr 
    690                 695                 700                 


Pro Ala Gln Gln Glu Ala Asn Leu Val Pro Pro Lys Cys Tyr Gly Gly 
705                 710                 715                 720 


Ser Phe Ala Gln Arg Asn Leu Cys Asn Asp Asp Gly Gly Gly Gly Gly 
                725                 730                 735     


Gly Ser Gly Thr Ala Gly Gly Gly Trp Ser Gly Ile Thr Gly Phe Phe 
            740                 745                 750         


Thr Pro Arg Leu Ile Lys Lys Thr Leu Gly Leu Arg Ala Gly Lys Pro 
        755                 760                 765             


Thr Ala Ser Asp Asp Thr Ser Lys Pro Phe Pro Arg Ser Asn Ser Thr 
    770                 775                 780                 


Ser Ser Met Ser Ser Gly Leu Pro Glu Gln Asp Arg Met Ala Met Thr 
785                 790                 795                 800 


Leu Pro Arg Asn Cys Gln Arg Ser Lys Leu Gln Leu Glu Arg Thr Val 
                805                 810                 815     


Ser Thr Ser Ser Gln Pro Glu Glu Asn Val Asp Arg Ala Asn Asp Met 
            820                 825                 830         


Leu Pro Lys Lys Ser Glu Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro 
        835                 840                 845             


Lys Ala Lys Leu Leu Pro Arg Gly Ala Thr Ala Leu Pro Leu Arg Thr 
    850                 855                 860                 


Pro Ser Gly Asp Leu Ala Ile Thr Glu Lys Asp Pro Pro Gly Val Gly 
865                 870                 875                 880 


Val Ala Gly Val Ala Ala Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly 
                885                 890                 895     


Ala Arg Leu Gly Met Ala Gly Val Pro Glu Asp Gly Glu Gln Pro Gly 
            900                 905                 910         


Trp Pro Ser Pro Ala Lys Ala Ala Pro Val Leu Pro Thr Thr His Asn 
        915                 920                 925             


His Lys Val Pro Val Leu Ile Ser Pro Thr Leu Lys His Thr Pro Ala 
    930                 935                 940                 


Asp Val Gln Leu Ile Gly Thr Asp Ser Gln Gly Asn Lys Phe Lys Leu 
945                 950                 955                 960 


Leu Ser Glu His Gln Val Thr Ser Ser Gly Asp Lys Asp Arg Pro Arg 
                965                 970                 975     


Arg Val Lys Pro Lys Cys Ala Pro Pro Pro Pro Pro Val Met Arg Leu 
            980                 985                 990         


Leu Gln His Pro Ser Ile Cys Ser  Asp Pro Thr Glu Glu  Pro Thr Ala 
        995                 1000                 1005             


Leu Thr  Ala Gly Gln Ser Thr  Ser Glu Thr Gln Glu  Gly Gly Lys 
    1010                 1015                 1020             


Lys Ala  Ala Leu Gly Ala Val  Pro Ile Ser Gly Lys  Ala Gly Arg 
    1025                 1030                 1035             


Pro Val  Met Pro Pro Pro Gln  Val Pro Leu Pro Thr  Ser Ser Ile 
    1040                 1045                 1050             


Ser Pro  Ala Lys Met Ala Asn  Gly Thr Ala Gly Thr  Lys Val Ala 
    1055                 1060                 1065             


Leu Arg  Lys Thr Lys Gln Ala  Ala Glu Lys Ile Ser  Ala Asp Lys 
    1070                 1075                 1080             


Ile Ser  Lys Glu Ala Leu Leu  Glu Cys Ala Asp Leu  Leu Ser Ser 
    1085                 1090                 1095             


Ala Leu  Thr Glu Pro Val Pro  Asn Ser Gln Leu Val  Asp Thr Gly 
    1100                 1105                 1110             


His Gln  Leu Leu Asp Tyr Cys  Ser Gly Tyr Val Asp  Cys Ile Pro 
    1115                 1120                 1125             


Gln Thr  Arg Asn Lys Phe Ala  Phe Arg Glu Ala Val  Ser Lys Leu 
    1130                 1135                 1140             


Glu Leu  Ser Leu Gln Glu Leu  Gln Val Ser Ser Ala  Ala Ala Gly 
    1145                 1150                 1155             


Val Pro  Gly Thr Asn Pro Val  Leu Asn Asn Leu Leu  Ser Cys Val 
    1160                 1165                 1170             


Gln Glu  Ile Ser Asp Val Val  Gln Arg 
    1175                 1180         


<210>  229
<211>  981
<212>  PRT
<213>  homo sapiens

<400>  229

Met Ala Glu Gly Gly Ala Ala Asp Leu Asp Thr Gln Arg Ser Asp Ile 
1               5                   10                  15      


Ala Thr Leu Leu Lys Thr Ser Leu Arg Lys Gly Asp Thr Trp Tyr Leu 
            20                  25                  30          


Val Asp Ser Arg Trp Phe Lys Gln Trp Lys Lys Tyr Val Gly Phe Asp 
        35                  40                  45              


Ser Trp Asp Lys Tyr Gln Met Gly Asp Gln Asn Val Tyr Pro Gly Pro 
    50                  55                  60                  


Ile Asp Asn Ser Gly Leu Leu Lys Asp Gly Asp Ala Gln Ser Leu Lys 
65                  70                  75                  80  


Glu His Leu Ile Asp Glu Leu Asp Tyr Ile Leu Leu Pro Thr Glu Gly 
                85                  90                  95      


Trp Asn Lys Leu Val Ser Trp Tyr Thr Leu Met Glu Gly Gln Glu Pro 
            100                 105                 110         


Ile Ala Arg Lys Val Val Glu Gln Gly Met Phe Val Lys His Cys Lys 
        115                 120                 125             


Val Glu Val Tyr Leu Thr Glu Leu Lys Leu Cys Glu Asn Gly Asn Met 
    130                 135                 140                 


Asn Asn Val Val Thr Arg Arg Phe Ser Lys Ala Asp Thr Ile Asp Thr 
145                 150                 155                 160 


Ile Glu Lys Glu Ile Arg Lys Ile Phe Ser Ile Pro Asp Glu Lys Glu 
                165                 170                 175     


Thr Arg Leu Trp Asn Lys Tyr Met Ser Asn Thr Phe Glu Pro Leu Asn 
            180                 185                 190         


Lys Pro Asp Ser Thr Ile Gln Asp Ala Gly Leu Tyr Gln Gly Gln Val 
        195                 200                 205             


Leu Val Ile Glu Gln Lys Asn Glu Asp Gly Thr Trp Pro Arg Gly Pro 
    210                 215                 220                 


Ser Thr Pro Lys Ser Pro Gly Ala Ser Asn Phe Ser Thr Leu Pro Lys 
225                 230                 235                 240 


Ile Ser Pro Ser Ser Leu Ser Asn Asn Tyr Asn Asn Met Asn Asn Arg 
                245                 250                 255     


Asn Val Lys Asn Ser Asn Tyr Cys Leu Pro Ser Tyr Thr Ala Tyr Lys 
            260                 265                 270         


Asn Tyr Asp Tyr Ser Glu Pro Gly Arg Asn Asn Glu Gln Pro Gly Leu 
        275                 280                 285             


Cys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ala Ile 
    290                 295                 300                 


Gln Cys Leu Ser Asn Thr Pro Pro Leu Thr Glu Tyr Phe Leu Asn Asp 
305                 310                 315                 320 


Lys Tyr Gln Glu Glu Leu Asn Phe Asp Asn Pro Leu Gly Met Arg Gly 
                325                 330                 335     


Glu Ile Ala Lys Ser Tyr Ala Glu Leu Ile Lys Gln Met Trp Ser Gly 
            340                 345                 350         


Lys Phe Ser Tyr Val Thr Pro Arg Ala Phe Lys Thr Gln Val Gly Arg 
        355                 360                 365             


Phe Ala Pro Gln Phe Ser Gly Tyr Gln Gln Gln Asp Cys Gln Glu Leu 
    370                 375                 380                 


Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile Arg 
385                 390                 395                 400 


Lys Lys Pro Tyr Ile Gln Leu Lys Asp Ala Asp Gly Arg Pro Asp Lys 
                405                 410                 415     


Val Val Ala Glu Glu Ala Trp Glu Asn His Leu Lys Arg Asn Asp Ser 
            420                 425                 430         


Ile Ile Val Asp Ile Phe His Gly Leu Phe Lys Ser Thr Leu Val Cys 
        435                 440                 445             


Pro Glu Cys Ala Lys Ile Ser Val Thr Phe Asp Pro Phe Cys Tyr Leu 
    450                 455                 460                 


Thr Leu Pro Leu Pro Met Lys Lys Glu Arg Thr Leu Glu Val Tyr Leu 
465                 470                 475                 480 


Val Arg Met Asp Pro Leu Thr Lys Pro Met Gln Tyr Lys Val Val Val 
                485                 490                 495     


Pro Lys Ile Gly Asn Ile Leu Asp Leu Cys Thr Ala Leu Ser Ala Leu 
            500                 505                 510         


Ser Gly Ile Pro Ala Asp Lys Met Ile Val Thr Asp Ile Tyr Asn His 
        515                 520                 525             


Arg Phe His Arg Ile Phe Ala Met Asp Glu Asn Leu Ser Ser Ile Met 
    530                 535                 540                 


Glu Arg Asp Asp Ile Tyr Val Phe Glu Ile Asn Ile Asn Arg Thr Glu 
545                 550                 555                 560 


Asp Thr Glu His Val Ile Ile Pro Val Cys Leu Arg Glu Lys Phe Arg 
                565                 570                 575     


His Ser Ser Tyr Thr His His Thr Gly Ser Ser Leu Phe Gly Gln Pro 
            580                 585                 590         


Phe Leu Met Ala Val Pro Arg Asn Asn Thr Glu Asp Lys Leu Tyr Asn 
        595                 600                 605             


Leu Leu Leu Leu Arg Met Cys Arg Tyr Val Lys Ile Ser Thr Glu Thr 
    610                 615                 620                 


Glu Glu Thr Glu Gly Ser Leu His Cys Cys Lys Asp Gln Asn Ile Asn 
625                 630                 635                 640 


Gly Asn Gly Pro Asn Gly Ile His Glu Glu Gly Ser Pro Ser Glu Met 
                645                 650                 655     


Glu Thr Asp Glu Pro Asp Asp Glu Ser Ser Gln Asp Gln Glu Leu Pro 
            660                 665                 670         


Ser Glu Asn Glu Asn Ser Gln Ser Glu Asp Ser Val Gly Gly Asp Asn 
        675                 680                 685             


Asp Ser Glu Asn Gly Leu Cys Thr Glu Asp Thr Cys Lys Gly Gln Leu 
    690                 695                 700                 


Thr Gly His Lys Lys Arg Leu Phe Thr Phe Gln Phe Asn Asn Leu Gly 
705                 710                 715                 720 


Asn Thr Asp Ile Asn Tyr Ile Lys Asp Asp Thr Arg His Ile Arg Phe 
                725                 730                 735     


Asp Asp Arg Gln Leu Arg Leu Asp Glu Arg Ser Phe Leu Ala Leu Asp 
            740                 745                 750         


Trp Asp Pro Asp Leu Lys Lys Arg Tyr Phe Asp Glu Asn Ala Ala Glu 
        755                 760                 765             


Asp Phe Glu Lys His Glu Ser Val Glu Tyr Lys Pro Pro Lys Lys Pro 
    770                 775                 780                 


Phe Val Lys Leu Lys Asp Cys Ile Glu Leu Phe Thr Thr Lys Glu Lys 
785                 790                 795                 800 


Leu Gly Ala Glu Asp Pro Trp Tyr Cys Pro Asn Cys Lys Glu His Gln 
                805                 810                 815     


Gln Ala Thr Lys Lys Leu Asp Leu Trp Ser Leu Pro Pro Val Leu Val 
            820                 825                 830         


Val His Leu Lys Arg Phe Ser Tyr Ser Arg Tyr Met Arg Asp Lys Leu 
        835                 840                 845             


Asp Thr Leu Val Asp Phe Pro Ile Asn Asp Leu Asp Met Ser Glu Phe 
    850                 855                 860                 


Leu Ile Asn Pro Asn Ala Gly Pro Cys Arg Tyr Asn Leu Ile Ala Val 
865                 870                 875                 880 


Ser Asn His Tyr Gly Gly Met Gly Gly Gly His Tyr Thr Ala Phe Ala 
                885                 890                 895     


Lys Asn Lys Asp Asp Gly Lys Trp Tyr Tyr Phe Asp Asp Ser Ser Val 
            900                 905                 910         


Ser Thr Ala Ser Glu Asp Gln Ile Val Ser Lys Ala Ala Tyr Val Leu 
        915                 920                 925             


Phe Tyr Gln Arg Gln Asp Thr Phe Ser Gly Thr Gly Phe Phe Pro Leu 
    930                 935                 940                 


Asp Arg Glu Thr Lys Gly Ala Ser Ala Ala Thr Gly Ile Pro Leu Glu 
945                 950                 955                 960 


Ser Asp Glu Asp Ser Asn Asp Asn Asp Asn Asp Ile Glu Asn Glu Asn 
                965                 970                 975     


Cys Met His Thr Asn 
            980     


<210>  230
<211>  424
<212>  PRT
<213>  homo sapiens

<400>  230

Met Asp Ser Gly Pro Leu Trp Asp Ala Asn Pro Thr Pro Arg Gly Thr 
1               5                   10                  15      


Leu Ser Ala Pro Asn Ala Thr Thr Pro Trp Leu Gly Arg Asp Glu Glu 
            20                  25                  30          


Leu Ala Lys Val Glu Ile Gly Val Leu Ala Thr Val Leu Val Leu Ala 
        35                  40                  45              


Thr Gly Gly Asn Leu Ala Val Leu Leu Thr Leu Gly Gln Leu Gly Arg 
    50                  55                  60                  


Lys Arg Ser Arg Met His Leu Phe Val Leu His Leu Ala Leu Thr Asp 
65                  70                  75                  80  


Leu Ala Val Ala Leu Phe Gln Val Leu Pro Gln Leu Leu Trp Asp Ile 
                85                  90                  95      


Thr Tyr Arg Phe Gln Gly Pro Asp Leu Leu Cys Arg Ala Val Lys Tyr 
            100                 105                 110         


Leu Gln Val Leu Ser Met Phe Ala Ser Thr Tyr Met Leu Leu Ala Met 
        115                 120                 125             


Thr Leu Asp Arg Tyr Leu Ala Val Cys His Pro Leu Arg Ser Leu Gln 
    130                 135                 140                 


Gln Pro Gly Gln Ser Thr Tyr Leu Leu Ile Ala Ala Pro Trp Leu Leu 
145                 150                 155                 160 


Ala Ala Ile Phe Ser Leu Pro Gln Val Phe Ile Phe Ser Leu Arg Glu 
                165                 170                 175     


Val Ile Gln Gly Ser Gly Val Leu Asp Cys Trp Ala Asp Phe Gly Phe 
            180                 185                 190         


Pro Trp Gly Pro Arg Ala Tyr Leu Thr Trp Thr Thr Leu Ala Ile Phe 
        195                 200                 205             


Val Leu Pro Val Thr Met Leu Thr Ala Cys Tyr Ser Leu Ile Cys His 
    210                 215                 220                 


Glu Ile Cys Lys Asn Leu Lys Val Lys Thr Gln Ala Trp Arg Val Gly 
225                 230                 235                 240 


Gly Gly Gly Trp Arg Thr Trp Asp Arg Pro Ser Pro Ser Thr Leu Ala 
                245                 250                 255     


Ala Thr Thr Arg Gly Leu Pro Ser Arg Val Ser Ser Ile Asn Thr Ile 
            260                 265                 270         


Ser Arg Ala Lys Ile Arg Thr Val Lys Met Thr Phe Val Ile Val Leu 
        275                 280                 285             


Ala Tyr Ile Ala Cys Trp Ala Pro Phe Phe Ser Val Gln Met Trp Ser 
    290                 295                 300                 


Val Trp Asp Lys Asn Ala Pro Asp Glu Asp Ser Thr Asn Val Ala Phe 
305                 310                 315                 320 


Thr Ile Ser Met Leu Leu Gly Asn Leu Asn Ser Cys Cys Asn Pro Trp 
                325                 330                 335     


Ile Tyr Met Gly Phe Asn Ser His Leu Leu Pro Arg Pro Leu Arg His 
            340                 345                 350         


Leu Ala Cys Cys Gly Gly Pro Gln Pro Arg Met Arg Arg Arg Leu Ser 
        355                 360                 365             


Asp Gly Ser Leu Ser Ser Arg His Thr Thr Leu Leu Thr Arg Ser Ser 
    370                 375                 380                 


Cys Pro Ala Thr Leu Ser Leu Ser Leu Ser Leu Thr Leu Ser Gly Arg 
385                 390                 395                 400 


Pro Arg Pro Glu Glu Ser Pro Arg Asp Leu Glu Leu Ala Asp Gly Glu 
                405                 410                 415     


Gly Thr Ala Glu Thr Ile Ile Phe 
            420                 


<210>  231
<211>  943
<212>  PRT
<213>  homo sapiens

<400>  231

Met Gly Leu Thr Lys Gln Tyr Leu Arg Tyr Val Ala Ser Ala Val Phe 
1               5                   10                  15      


Gly Val Ile Gly Ser Gln Lys Gly Asn Ile Val Phe Val Thr Leu Arg 
            20                  25                  30          


Gly Glu Lys Gly Arg Tyr Val Ala Val Pro Ala Cys Glu His Val Phe 
        35                  40                  45              


Ile Trp Asp Leu Arg Lys Gly Glu Lys Ile Leu Ile Leu Gln Gly Leu 
    50                  55                  60                  


Lys Gln Glu Val Thr Cys Leu Cys Pro Ser Pro Asp Gly Leu His Leu 
65                  70                  75                  80  


Ala Val Gly Tyr Glu Asp Gly Ser Ile Arg Ile Phe Ser Leu Leu Ser 
                85                  90                  95      


Gly Glu Gly Asn Val Thr Phe Asn Gly His Lys Ala Ala Ile Thr Thr 
            100                 105                 110         


Leu Lys Tyr Asp Gln Leu Gly Gly Arg Leu Ala Ser Gly Ser Lys Asp 
        115                 120                 125             


Thr Asp Ile Ile Val Trp Asp Val Ile Asn Glu Ser Gly Leu Tyr Arg 
    130                 135                 140                 


Leu Lys Gly His Lys Asp Ala Ile Thr Gln Ala Leu Phe Leu Arg Glu 
145                 150                 155                 160 


Lys Asn Leu Leu Val Thr Ser Gly Lys Asp Thr Met Val Lys Trp Trp 
                165                 170                 175     


Asp Leu Asp Thr Gln His Cys Phe Lys Thr Met Val Gly His Arg Thr 
            180                 185                 190         


Glu Val Trp Gly Leu Val Leu Leu Ser Glu Glu Lys Arg Leu Ile Thr 
        195                 200                 205             


Gly Ala Ser Asp Ser Glu Leu Arg Val Trp Asp Ile Ala Tyr Leu Gln 
    210                 215                 220                 


Glu Ile Glu Asp Pro Glu Glu Pro Asp Pro Lys Lys Ile Lys Gly Ser 
225                 230                 235                 240 


Ser Pro Gly Ile Gln Asp Thr Leu Glu Ala Glu Asp Gly Ala Phe Glu 
                245                 250                 255     


Thr Asp Glu Ala Pro Glu Asp Arg Ile Leu Ser Cys Arg Lys Ala Gly 
            260                 265                 270         


Ser Ile Met Arg Glu Gly Arg Asp Arg Val Val Asn Leu Ala Val Asp 
        275                 280                 285             


Lys Thr Gly Arg Ile Leu Ala Cys His Gly Thr Asp Ser Val Leu Glu 
    290                 295                 300                 


Leu Phe Cys Ile Leu Ser Lys Lys Glu Ile Gln Lys Lys Met Asp Lys 
305                 310                 315                 320 


Lys Met Lys Lys Ala Arg Lys Lys Ala Lys Leu His Ser Ser Lys Gly 
                325                 330                 335     


Glu Glu Glu Asp Pro Glu Val Asn Val Glu Met Ser Leu Gln Asp Glu 
            340                 345                 350         


Ile Gln Arg Val Thr Asn Ile Lys Thr Ser Ala Lys Ile Lys Ser Phe 
        355                 360                 365             


Asp Leu Ile His Ser Pro His Gly Glu Leu Lys Ala Val Phe Leu Leu 
    370                 375                 380                 


Gln Asn Asn Leu Val Glu Leu Tyr Ser Leu Asn Pro Ser Leu Pro Thr 
385                 390                 395                 400 


Pro Gln Pro Val Arg Thr Ser Arg Ile Thr Ile Gly Gly His Arg Ser 
                405                 410                 415     


Asp Val Arg Thr Leu Ser Phe Ser Ser Asp Asn Ile Ala Val Leu Ser 
            420                 425                 430         


Ala Ala Ala Asp Ser Ile Lys Ile Trp Asn Arg Ser Thr Leu Gln Cys 
        435                 440                 445             


Ile Arg Thr Met Thr Cys Glu Tyr Ala Leu Cys Ser Phe Phe Val Pro 
    450                 455                 460                 


Gly Asp Arg Gln Val Val Ile Gly Thr Lys Thr Gly Lys Leu Gln Leu 
465                 470                 475                 480 


Tyr Asp Leu Ala Ser Gly Asn Leu Leu Glu Thr Ile Asp Ala His Asp 
                485                 490                 495     


Gly Ala Leu Trp Ser Met Ser Leu Ser Pro Asp Gln Arg Gly Phe Val 
            500                 505                 510         


Thr Gly Gly Ala Asp Lys Ser Val Lys Phe Trp Asp Phe Glu Leu Val 
        515                 520                 525             


Lys Asp Glu Asn Ser Thr Gln Lys Arg Leu Ser Val Lys Gln Thr Arg 
    530                 535                 540                 


Thr Leu Gln Leu Asp Glu Asp Val Leu Cys Val Ser Tyr Ser Pro Asn 
545                 550                 555                 560 


Gln Lys Leu Leu Ala Val Ser Leu Leu Asp Cys Thr Val Lys Ile Phe 
                565                 570                 575     


Tyr Val Asp Thr Leu Lys Phe Phe Leu Ser Leu Tyr Gly His Lys Leu 
            580                 585                 590         


Pro Val Ile Cys Met Asp Ile Ser His Asp Gly Ala Leu Ile Ala Thr 
        595                 600                 605             


Gly Ser Ala Asp Arg Asn Val Lys Ile Trp Gly Leu Asp Phe Gly Asp 
    610                 615                 620                 


Cys His Lys Ser Leu Phe Ala His Asp Asp Ser Val Met Tyr Leu Gln 
625                 630                 635                 640 


Phe Val Pro Lys Ser His Leu Phe Phe Thr Ala Gly Lys Asp His Lys 
                645                 650                 655     


Ile Lys Gln Trp Asp Ala Asp Lys Phe Glu His Ile Gln Thr Leu Glu 
            660                 665                 670         


Gly His His Gln Glu Ile Trp Cys Leu Ala Val Ser Pro Ser Gly Asp 
        675                 680                 685             


Tyr Val Val Ser Ser Ser His Asp Lys Ser Leu Arg Leu Trp Glu Arg 
    690                 695                 700                 


Thr Arg Glu Pro Leu Ile Leu Glu Glu Glu Arg Glu Met Glu Arg Glu 
705                 710                 715                 720 


Ala Glu Tyr Glu Glu Ser Val Ala Lys Glu Asp Gln Pro Ala Val Pro 
                725                 730                 735     


Gly Glu Thr Gln Gly Asp Ser Tyr Phe Thr Gly Lys Lys Thr Ile Glu 
            740                 745                 750         


Thr Val Lys Ala Ala Glu Arg Ile Met Glu Ala Ile Glu Leu Tyr Arg 
        755                 760                 765             


Glu Glu Thr Ala Lys Met Lys Glu His Lys Ala Ile Cys Lys Ala Ala 
    770                 775                 780                 


Gly Lys Glu Val Pro Leu Pro Ser Asn Pro Ile Leu Met Ala Tyr Gly 
785                 790                 795                 800 


Ser Ile Ser Pro Ser Ala Tyr Val Leu Glu Ile Phe Lys Gly Ile Lys 
                805                 810                 815     


Ser Ser Glu Leu Glu Glu Ser Leu Leu Val Leu Pro Phe Ser Tyr Val 
            820                 825                 830         


Pro Asp Ile Leu Lys Leu Phe Asn Glu Phe Ile Gln Leu Gly Ser Asp 
        835                 840                 845             


Val Glu Leu Ile Cys Arg Cys Leu Phe Phe Leu Leu Arg Ile His Phe 
    850                 855                 860                 


Gly Gln Ile Thr Ser Asn Gln Met Leu Val Pro Val Ile Glu Lys Leu 
865                 870                 875                 880 


Arg Glu Thr Thr Ile Ser Lys Val Ser Gln Val Arg Asp Val Ile Gly 
                885                 890                 895     


Phe Asn Met Ala Gly Leu Asp Tyr Leu Lys Arg Glu Cys Glu Ala Lys 
            900                 905                 910         


Ser Glu Val Met Phe Phe Ala Asp Ala Thr Ser His Leu Glu Glu Lys 
        915                 920                 925             


Lys Arg Lys Arg Lys Lys Arg Glu Lys Leu Ile Leu Thr Leu Thr 
    930                 935                 940             


<210>  232
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  232

Trp Ile Thr His Asp Arg Ala Trp Asn 
1               5                   


<210>  233
<211>  1914
<212>  PRT
<213>  homo sapiens

<400>  233

Met Ala Asp Gly Lys Gly Asp Ala Ala Ala Val Ala Gly Ala Gly Ala 
1               5                   10                  15      


Glu Ala Pro Ala Val Ala Gly Ala Gly Asp Gly Val Glu Thr Glu Ser 
            20                  25                  30          


Met Val Arg Gly His Arg Pro Val Ser Pro Ala Pro Gly Ala Ser Gly 
        35                  40                  45              


Leu Arg Pro Cys Leu Trp Gln Leu Glu Thr Glu Leu Arg Glu Gln Glu 
    50                  55                  60                  


Val Ser Glu Val Ser Ser Leu Asn Tyr Cys Arg Ser Phe Cys Gln Thr 
65                  70                  75                  80  


Leu Leu Gln Tyr Ala Ser Asn Lys Asn Ala Ser Glu His Ile Val Tyr 
                85                  90                  95      


Leu Leu Glu Val Tyr Arg Leu Ala Ile Gln Ser Phe Ala Ser Ala Arg 
            100                 105                 110         


Pro Tyr Leu Thr Thr Glu Cys Glu Asp Val Leu Leu Val Leu Gly Arg 
        115                 120                 125             


Leu Val Leu Ser Cys Phe Glu Leu Leu Leu Ser Val Ser Glu Ser Glu 
    130                 135                 140                 


Leu Pro Cys Glu Val Trp Leu Pro Phe Leu Gln Ser Leu Gln Glu Ser 
145                 150                 155                 160 


His Asp Ala Leu Leu Glu Phe Gly Asn Asn Asn Leu Gln Ile Leu Val 
                165                 170                 175     


His Val Thr Lys Glu Gly Val Trp Lys Asn Pro Val Leu Leu Lys Ile 
            180                 185                 190         


Leu Ser Gln Gln Pro Val Glu Thr Glu Glu Val Asn Lys Leu Ile Ala 
        195                 200                 205             


Gln Glu Gly Pro Ser Phe Leu Gln Met Arg Ile Lys His Leu Leu Lys 
    210                 215                 220                 


Ser Asn Cys Ile Pro Gln Ala Thr Ala Leu Ser Lys Leu Cys Ala Glu 
225                 230                 235                 240 


Ser Lys Glu Ile Ser Asn Val Ser Ser Phe Gln Gln Ala Tyr Ile Thr 
                245                 250                 255     


Cys Leu Cys Ser Met Leu Pro Asn Glu Asp Ala Ile Lys Glu Ile Ala 
            260                 265                 270         


Lys Val Asp Cys Lys Glu Val Leu Asp Ile Ile Cys Asn Leu Glu Ser 
        275                 280                 285             


Glu Gly Gln Asp Asn Thr Ala Phe Val Leu Cys Thr Thr Tyr Leu Thr 
    290                 295                 300                 


Gln Gln Leu Gln Thr Ala Ser Val Tyr Cys Ser Trp Glu Leu Thr Leu 
305                 310                 315                 320 


Phe Trp Ser Lys Leu Gln Arg Arg Ile Asp Pro Ser Leu Asp Thr Phe 
                325                 330                 335     


Leu Glu Arg Cys Arg Gln Phe Gly Val Ile Ala Lys Thr Gln Gln His 
            340                 345                 350         


Leu Phe Cys Leu Ile Arg Val Ile Gln Thr Glu Ala Gln Asp Ala Gly 
        355                 360                 365             


Leu Gly Val Ser Ile Leu Leu Cys Val Arg Ala Leu Gln Leu Arg Ser 
    370                 375                 380                 


Ser Glu Asp Glu Glu Met Lys Ala Ser Val Cys Lys Thr Ile Ala Cys 
385                 390                 395                 400 


Leu Leu Pro Glu Asp Leu Glu Val Arg Arg Ala Cys Gln Leu Thr Glu 
                405                 410                 415     


Phe Leu Ile Glu Pro Ser Leu Asp Gly Phe Asn Met Leu Glu Glu Leu 
            420                 425                 430         


Tyr Leu Gln Pro Asp Gln Lys Phe Asp Glu Glu Asn Ala Pro Val Pro 
        435                 440                 445             


Asn Ser Leu Arg Cys Glu Leu Leu Leu Ala Leu Lys Ala His Trp Pro 
    450                 455                 460                 


Phe Asp Pro Glu Phe Trp Asp Trp Lys Thr Leu Lys Arg His Cys His 
465                 470                 475                 480 


Gln Leu Leu Gly Gln Glu Ala Ser Asp Ser Asp Asp Asp Leu Ser Gly 
                485                 490                 495     


Tyr Glu Met Ser Ile Asn Asp Thr Asp Val Leu Glu Ser Phe Leu Ser 
            500                 505                 510         


Asp Tyr Asp Glu Gly Lys Glu Asp Lys Gln Tyr Arg Arg Arg Asp Leu 
        515                 520                 525             


Thr Asp Gln His Lys Glu Lys Arg Asp Lys Lys Pro Ile Gly Ser Ser 
    530                 535                 540                 


Glu Arg Tyr Gln Arg Trp Leu Gln Tyr Lys Phe Phe Cys Leu Leu Cys 
545                 550                 555                 560 


Lys Arg Glu Cys Ile Glu Ala Arg Ile Leu His His Ser Lys Met His 
                565                 570                 575     


Met Glu Asp Gly Ile Tyr Thr Cys Pro Val Cys Ile Lys Lys Phe Lys 
            580                 585                 590         


Arg Lys Glu Met Phe Val Pro His Val Met Glu His Val Lys Met Pro 
        595                 600                 605             


Pro Ser Arg Arg Asp Arg Ser Lys Lys Lys Leu Leu Leu Lys Gly Ser 
    610                 615                 620                 


Gln Lys Gly Ile Cys Pro Lys Ser Pro Ser Ala Ile Pro Glu Gln Asn 
625                 630                 635                 640 


His Ser Leu Asn Asp Gln Ala Lys Gly Glu Ser His Glu Tyr Val Thr 
                645                 650                 655     


Phe Ser Lys Leu Glu Asp Cys His Leu Gln Asp Arg Asp Leu Tyr Pro 
            660                 665                 670         


Cys Pro Gly Thr Asp Cys Ser Arg Val Phe Lys Gln Phe Lys Tyr Leu 
        675                 680                 685             


Ser Val His Leu Lys Ala Glu His Gln Asn Asn Asp Glu Asn Ala Lys 
    690                 695                 700                 


His Tyr Leu Asp Met Lys Asn Arg Arg Glu Lys Cys Thr Tyr Cys Arg 
705                 710                 715                 720 


Arg His Phe Met Ser Ala Phe His Leu Arg Glu His Glu Gln Val His 
                725                 730                 735     


Cys Gly Pro Gln Pro Tyr Met Cys Val Ser Ile Asp Cys Tyr Ala Arg 
            740                 745                 750         


Phe Gly Ser Val Asn Glu Leu Leu Asn His Lys Gln Lys His Asp Asp 
        755                 760                 765             


Leu Arg Tyr Lys Cys Glu Leu Asn Gly Cys Asn Ile Val Phe Ser Asp 
    770                 775                 780                 


Leu Gly Gln Leu Tyr His His Glu Ala Gln His Phe Arg Asp Ala Ser 
785                 790                 795                 800 


Tyr Thr Cys Asn Phe Leu Gly Cys Lys Lys Phe Tyr Tyr Ser Lys Ile 
                805                 810                 815     


Glu Tyr Gln Asn His Leu Ser Met His Asn Val Glu Asn Ser Asn Gly 
            820                 825                 830         


Asp Ile Lys Lys Ser Val Lys Leu Glu Glu Ser Ala Thr Gly Glu Lys 
        835                 840                 845             


Gln Asp Cys Ile Asn Gln Pro His Leu Leu Asn Gln Thr Asp Lys Ser 
    850                 855                 860                 


His Leu Pro Glu Asp Leu Phe Cys Ala Glu Ser Ala Asn Ser Gln Ile 
865                 870                 875                 880 


Asp Thr Glu Thr Ala Glu Asn Leu Lys Glu Asn Ser Asp Ser Asn Ser 
                885                 890                 895     


Ser Asp Gln Leu Ser His Ser Ser Ser Ala Ser Met Asn Glu Glu Leu 
            900                 905                 910         


Ile Asp Thr Leu Asp His Ser Glu Thr Met Gln Asp Val Leu Leu Ser 
        915                 920                 925             


Asn Glu Lys Val Phe Gly Pro Ser Ser Leu Lys Glu Lys Cys Ser Ser 
    930                 935                 940                 


Met Ala Val Cys Phe Asp Gly Thr Lys Phe Thr Cys Gly Phe Asp Gly 
945                 950                 955                 960 


Cys Gly Ser Thr Tyr Lys Asn Ala Arg Gly Met Gln Lys His Leu Arg 
                965                 970                 975     


Lys Val His Pro Tyr His Phe Lys Pro Lys Lys Ile Lys Thr Lys Asp 
            980                 985                 990         


Leu Phe Pro Ser Leu Gly Asn Glu  His Asn Gln Thr Thr  Glu Lys Leu 
        995                 1000                 1005             


Asp Ala  Glu Pro Lys Pro Cys  Ser Asp Thr Asn Ser  Asp Ser Pro 
    1010                 1015                 1020             


Asp Glu  Gly Leu Asp His Asn  Ile His Ile Lys Cys  Lys Arg Glu 
    1025                 1030                 1035             


His Gln  Gly Tyr Ser Ser Glu  Ser Ser Ile Cys Ala  Ser Lys Arg 
    1040                 1045                 1050             


Pro Cys  Thr Glu Asp Thr Met  Leu Glu Leu Leu Leu  Arg Leu Lys 
    1055                 1060                 1065             


His Leu  Ser Leu Lys Asn Ser  Ile Thr His Gly Ser  Phe Ser Gly 
    1070                 1075                 1080             


Ser Leu  Gln Gly Tyr Pro Ser  Ser Gly Ala Lys Ser  Leu Gln Ser 
    1085                 1090                 1095             


Val Ser  Ser Ile Ser Asp Leu  Asn Phe Gln Asn Gln  Asp Glu Asn 
    1100                 1105                 1110             


Met Pro  Ser Gln Tyr Leu Ala  Gln Leu Ala Ala Lys  Pro Phe Phe 
    1115                 1120                 1125             


Cys Glu  Leu Gln Gly Cys Lys  Tyr Glu Phe Val Thr  Arg Glu Ala 
    1130                 1135                 1140             


Leu Leu  Met His Tyr Leu Lys  Lys His Asn Tyr Ser  Lys Glu Lys 
    1145                 1150                 1155             


Val Leu  Gln Leu Thr Met Phe  Gln His Arg Tyr Ser  Pro Phe Gln 
    1160                 1165                 1170             


Cys His  Ile Cys Gln Arg Ser  Phe Thr Arg Lys Thr  His Leu Arg 
    1175                 1180                 1185             


Ile His  Tyr Lys Asn Lys His  Gln Ile Gly Ser Asp  Arg Ala Thr 
    1190                 1195                 1200             


His Lys  Leu Leu Asp Asn Glu  Lys Cys Asp His Glu  Gly Pro Cys 
    1205                 1210                 1215             


Ser Val  Asp Arg Leu Lys Gly  Asp Cys Ser Ala Glu  Leu Gly Gly 
    1220                 1225                 1230             


Asp Pro  Ser Ser Asn Ser Glu  Lys Pro His Cys His  Pro Lys Lys 
    1235                 1240                 1245             


Asp Glu  Cys Ser Ser Glu Thr  Asp Leu Glu Ser Ser  Cys Glu Glu 
    1250                 1255                 1260             


Thr Glu  Ser Lys Thr Ser Asp  Ile Ser Ser Pro Ile  Gly Ser His 
    1265                 1270                 1275             


Arg Glu  Glu Gln Glu Gly Arg  Glu Gly Arg Gly Ser  Arg Arg Thr 
    1280                 1285                 1290             


Val Ala  Lys Gly Asn Leu Cys  Tyr Ile Leu Asn Lys  Tyr His Lys 
    1295                 1300                 1305             


Pro Phe  His Cys Ile His Lys  Thr Cys Asn Ser Ser  Phe Thr Asn 
    1310                 1315                 1320             


Leu Lys  Gly Leu Ile Arg His  Tyr Arg Thr Val His  Gln Tyr Asn 
    1325                 1330                 1335             


Lys Glu  Gln Leu Cys Leu Glu  Lys Asp Lys Ala Arg  Thr Lys Arg 
    1340                 1345                 1350             


Glu Leu  Val Lys Cys Lys Lys  Ile Phe Ala Cys Lys  Tyr Lys Glu 
    1355                 1360                 1365             


Cys Asn  Lys Arg Phe Leu Cys  Ser Lys Ala Leu Ala  Lys His Cys 
    1370                 1375                 1380             


Ser Asp  Ser His Asn Leu Asp  His Ile Glu Glu Pro  Lys Val Leu 
    1385                 1390                 1395             


Ser Glu  Ala Gly Ser Ala Ala  Arg Phe Ser Cys Asn  Gln Pro Gln 
    1400                 1405                 1410             


Cys Pro  Ala Val Phe Tyr Thr  Phe Asn Lys Leu Lys  His His Leu 
    1415                 1420                 1425             


Met Glu  Gln His Asn Ile Glu  Gly Glu Ile His Ser  Asp Tyr Glu 
    1430                 1435                 1440             


Ile His  Cys Asp Leu Asn Gly  Cys Gly Gln Ile Phe  Thr His Arg 
    1445                 1450                 1455             


Ser Asn  Tyr Ser Gln His Val  Tyr Tyr Arg His Lys  Asp Tyr Tyr 
    1460                 1465                 1470             


Asp Asp  Leu Phe Arg Ser Gln  Lys Val Ala Asn Glu  Arg Leu Leu 
    1475                 1480                 1485             


Arg Ser  Glu Lys Val Cys Gln  Thr Ala Asp Thr Gln  Gly His Glu 
    1490                 1495                 1500             


His Gln  Thr Thr Arg Arg Ser  Phe Asn Ala Lys Ser  Lys Lys Cys 
    1505                 1510                 1515             


Gly Leu  Ile Lys Glu Lys Lys  Ala Pro Ile Ser Phe  Lys Thr Arg 
    1520                 1525                 1530             


Ala Glu  Ala Leu His Met Cys  Val Glu His Ser Glu  His Thr Gln 
    1535                 1540                 1545             


Tyr Pro  Cys Met Val Gln Gly  Cys Leu Ser Val Val  Lys Leu Glu 
    1550                 1555                 1560             


Ser Ser  Ile Val Arg His Tyr  Lys Arg Thr His Gln  Met Ser Ser 
    1565                 1570                 1575             


Ala Tyr  Leu Glu Gln Gln Met  Glu Asn Leu Val Val  Cys Val Lys 
    1580                 1585                 1590             


Tyr Gly  Thr Lys Ile Lys Glu  Glu Pro Pro Ser Glu  Ala Asp Pro 
    1595                 1600                 1605             


Cys Ile  Lys Lys Glu Glu Asn  Arg Ser Cys Glu Ser  Glu Arg Thr 
    1610                 1615                 1620             


Glu His  Ser His Ser Pro Gly  Asp Ser Ser Ala Pro  Ile Gln Asn 
    1625                 1630                 1635             


Thr Asp  Cys Cys His Ser Ser  Glu Arg Asp Gly Gly  Gln Lys Gly 
    1640                 1645                 1650             


Cys Ile  Glu Ser Ser Ser Val  Phe Asp Ala Asp Thr  Leu Leu Tyr 
    1655                 1660                 1665             


Arg Gly  Thr Leu Lys Cys Asn  His Ser Ser Lys Thr  Thr Ser Leu 
    1670                 1675                 1680             


Glu Gln  Cys Asn Ile Val Gln  Pro Pro Pro Pro Cys  Lys Ile Glu 
    1685                 1690                 1695             


Asn Ser  Ile Pro Asn Pro Asn  Gly Thr Glu Ser Gly  Thr Tyr Phe 
    1700                 1705                 1710             


Thr Ser  Phe Gln Leu Pro Leu  Pro Arg Ile Lys Glu  Ser Glu Thr 
    1715                 1720                 1725             


Arg Gln  His Ser Ser Gly Gln  Glu Asn Thr Val Lys  Asn Pro Thr 
    1730                 1735                 1740             


His Val  Pro Lys Glu Asn Phe  Arg Lys His Ser Gln  Pro Arg Ser 
    1745                 1750                 1755             


Phe Asp  Leu Lys Thr Tyr Lys  Pro Met Gly Phe Glu  Ser Ser Phe 
    1760                 1765                 1770             


Leu Lys  Phe Ile Gln Glu Ser  Glu Glu Lys Glu Asp  Asp Phe Asp 
    1775                 1780                 1785             


Asp Trp  Glu Pro Ser Glu His  Leu Thr Leu Ser Asn  Ser Ser Gln 
    1790                 1795                 1800             


Ser Ser  Asn Asp Leu Thr Gly  Asn Val Val Ala Asn  Asn Met Val 
    1805                 1810                 1815             


Asn Asp  Ser Glu Pro Glu Val  Asp Ile Pro His Ser  Ser Ser Asp 
    1820                 1825                 1830             


Ser Thr  Ile His Glu Asn Leu  Thr Ala Ile Pro Pro  Leu Ile Val 
    1835                 1840                 1845             


Ala Glu  Thr Thr Thr Val Pro  Ser Leu Glu Asn Leu  Arg Val Val 
    1850                 1855                 1860             


Leu Asp  Lys Ala Leu Thr Asp  Cys Gly Glu Leu Ala  Leu Lys Gln 
    1865                 1870                 1875             


Leu His  Tyr Leu Arg Pro Val  Val Val Leu Glu Arg  Ser Lys Phe 
    1880                 1885                 1890             


Ser Thr  Pro Ile Leu Asp Leu  Phe Pro Thr Lys Lys  Thr Asp Glu 
    1895                 1900                 1905             


Leu Cys  Val Gly Ser Ser 
    1910                 


