                         SEQUENCE LISTING

<110>  Bristol-Myers Squibb Company
 
<120>  IDENTIFICATION OF POLYNUCLEOTIDES FOR PREDICTING ACTIVITY OF 
       COMPOUNDS THAT INTERACT WITH AND/OR MODULATE PROTEIN TYROSINE 
       KINASES AND/OR PROTEIN TYROSINE KINASE PATHWAYS IN PROSTATE CELLS

<130>  10989 PCT

<150>  U.S. 60/879,374
<151>  2007-01-09

<150>  U.S. 60/899,260
<151>  2007-02-02

<160>  912   

<170>  PatentIn version 3.3

<210>  1
<211>  2320
<212>  DNA
<213>  Homo sapiens

<400>  1
tcgacagctc tctcgcccag cccagttctg gaagggataa aaagggggca tcaccgttcc     60

tgggtaacag agccaccttc tgcgtcctgc tgagctctgt tctctccagc acctcccaac    120

ccactagtgc ctggttctct tgctccacca ggaacaagcc accatgtctc gccagtcaag    180

tgtgtccttc cggagcgggg gcagtcgtag cttcagcacc gcctctgcca tcaccccgtc    240

tgtctcccgc accagcttca cctccgtgtc ccggtccggg ggtggcggtg gtggtggctt    300

cggcagggtc agccttgcgg gtgcttgtgg agtgggtggc tatggcagcc ggagcctcta    360

caacctgggg ggctccaaga ggatatccat cagcactagt ggtggcagct tcaggaaccg    420

gtttggtgct ggtgctggag gcggctatgg ctttggaggt ggtgccggta gtggatttgg    480

tttcggcggt ggagctggtg gtggctttgg gctcggtggc ggagctggct ttggaggtgg    540

cttcggtggc cctggctttc ctgtctgccc tcctggaggt atccaagagg tcactgtcaa    600

ccagagtctc ctgactcccc tcaacctgca aatcgacccc agcatccaga gggtgaggac    660

cgaggagcgc gagcagatca agaccctcaa caataagttt gcctccttca tcgacaaggt    720

gcggttcctg gagcagcaga acaaggttct ggacaccaag tggaccctgc tgcaggagca    780

gggcaccaag actgtgaggc agaacctgga gccgttgttc gagcagtaca tcaacaacct    840

caggaggcag ctggacagca tcgtggggga acggggccgc ctggactcag agctgagaaa    900

catgcaggac ctggtggaag acttcaagaa caagtatgag gatgaaatca acaagcgtac    960

cactgctgag aatgagtttg tgatgctgaa gaaggatgta gatgctgcct acatgaacaa   1020

ggtggagctg gaggccaagg ttgatgcact gatggatgag attaacttca tgaagatgtt   1080

ctttgatgcg gagctgtccc agatgcagac gcatgtctct gacacctcag tggtcctctc   1140

catggacaac aaccgcaacc tggacctgga tagcatcatc gctgaggtca aggcccagta   1200

tgaggagatt gccaaccgca gccggacaga agccgagtcc tggtatcaga ccaagtatga   1260

ggagctgcag cagacagctg gccggcatgg cgatgacctc cgcaacacca agcatgagat   1320

ctctgagatg aaccggatga tccagaggct gagagccgag attgacaatg tcaagaaaca   1380

gtgcgccaat ctgcagaacg ccattgcgga tgccgagcag cgtggggagc tggccctcaa   1440

ggatgccagg aacaagctgg ccgagctgga ggaggccctg cagaaggcca agcaggacat   1500

ggcccggctg ctgcgtgagt accaggagct catgaacacc aagctggccc tggacgtgga   1560

gatcgccact taccgcaagc tgctggaggg cgaggaatgc agactcagtg gagaaggagt   1620

tggaccagtc aacatctctg ttgtcacaag cagtgtttcc tctggatatg gcagtggcag   1680

tggctatggc ggtggcctcg gtggaggtct tggcggcggc ctcggtggag gtcttgccgg   1740

aggtagcagt ggaagctact actccagcag cagtgggggt gtcggcctag gtggtgggct   1800

cagtgtgggg ggctctggct tcagtgcaag cagtggccga gggctggggg tgggctttgg   1860

cagtggcggg ggtagcagct ccagcgtcaa atttgtctcc accacctcct cctcccggaa   1920

gagcttcaag agctaagaac ctgctgcaag tcactgcctt ccaagtgcag caacccagcc   1980

catggagatt gcctcttcta ggcagttgct caagccatgt tttatccttt tctggagagt   2040

agtctagacc aagccaattg cagaaccaca ttctttggtt cccaggagag ccccattccc   2100

agcccctggt ctcccgtgcc gcagttctat attctgcttc aaatcagcct tcaggtttcc   2160

cacagcatgg cccctgctga cacgagaacc caaagttttc ccaaatctaa atcatcaaaa   2220

cagaatcccc accccaatcc caaattttgt tttggttcta actacctcca gaatgtgttc   2280

aataaaatgc ttttataata taaaaaaaaa aaaaaaaaaa                         2320


<210>  2
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Arg Gln Ser Ser Val Ser Phe Arg Ser Gly Gly Ser Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ala Ser Ala Ile Thr Pro Ser Val Ser Arg Thr Ser Phe 
            20                  25                  30          


Thr Ser Val Ser Arg Ser Gly Gly Gly Gly Gly Gly Gly Phe Gly Arg 
        35                  40                  45              


Val Ser Leu Ala Gly Ala Cys Gly Val Gly Gly Tyr Gly Ser Arg Ser 
    50                  55                  60                  


Leu Tyr Asn Leu Gly Gly Ser Lys Arg Ile Ser Ile Ser Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Phe Arg Asn Arg Phe Gly Ala Gly Ala Gly Gly Gly Tyr Gly 
                85                  90                  95      


Phe Gly Gly Gly Ala Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly 
            100                 105                 110         


Gly Gly Phe Gly Leu Gly Gly Gly Ala Gly Phe Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Pro Gly Phe Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr 
    130                 135                 140                 


Val Asn Gln Ser Leu Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ser 
145                 150                 155                 160 


Ile Gln Arg Val Arg Thr Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn 
                165                 170                 175     


Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln 
            180                 185                 190         


Asn Lys Val Leu Asp Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr 
        195                 200                 205             


Lys Thr Val Arg Gln Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn 
    210                 215                 220                 


Asn Leu Arg Arg Gln Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu 
225                 230                 235                 240 


Asp Ser Glu Leu Arg Asn Met Gln Asp Leu Val Glu Asp Phe Lys Asn 
                245                 250                 255     


Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Thr Ala Glu Asn Glu Phe 
            260                 265                 270         


Val Met Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu 
        275                 280                 285             


Leu Glu Ala Lys Val Asp Ala Leu Met Asp Glu Ile Asn Phe Met Lys 
    290                 295                 300                 


Met Phe Phe Asp Ala Glu Leu Ser Gln Met Gln Thr His Val Ser Asp 
305                 310                 315                 320 


Thr Ser Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp 
                325                 330                 335     


Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Ile Ala Asn Arg 
            340                 345                 350         


Ser Arg Thr Glu Ala Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu 
        355                 360                 365             


Gln Gln Thr Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys His 
    370                 375                 380                 


Glu Ile Ser Glu Met Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile 
385                 390                 395                 400 


Asp Asn Val Lys Lys Gln Cys Ala Asn Leu Gln Asn Ala Ile Ala Asp 
                405                 410                 415     


Ala Glu Gln Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Asn Lys Leu 
            420                 425                 430         


Ala Glu Leu Glu Glu Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Arg 
        435                 440                 445             


Leu Leu Arg Glu Tyr Gln Glu Leu Met Asn Thr Lys Leu Ala Leu Asp 
    450                 455                 460                 


Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg 
465                 470                 475                 480 


Leu Ser Gly Glu Gly Val Gly Pro Val Asn Ile Ser Val Val Thr Ser 
                485                 490                 495     


Ser Val Ser Ser Gly Tyr Gly Ser Gly Ser Gly Tyr Gly Gly Gly Leu 
            500                 505                 510         


Gly Gly Gly Leu Gly Gly Gly Leu Gly Gly Gly Leu Ala Gly Gly Ser 
        515                 520                 525             


Ser Gly Ser Tyr Tyr Ser Ser Ser Ser Gly Gly Val Gly Leu Gly Gly 
    530                 535                 540                 


Gly Leu Ser Val Gly Gly Ser Gly Phe Ser Ala Ser Ser Gly Arg Gly 
545                 550                 555                 560 


Leu Gly Val Gly Phe Gly Ser Gly Gly Gly Ser Ser Ser Ser Val Lys 
                565                 570                 575     


Phe Val Ser Thr Thr Ser Ser Ser Arg Lys Ser Phe Lys Ser 
            580                 585                 590 


<210>  3
<211>  2360
<212>  DNA
<213>  Homo sapiens

<400>  3
acagtgcgga gaccgcagcc ccggagcccg ggccagggtc cacctgtccc cgcagcgccg     60

gctcgcgccc tcctgccgca gccaccgagc cgccgtctag cgccccgacc tcgccaccat    120

gagagccctg ctggcgcgcc tgcttctctg cgtcctggtc gtgagcgact ccaaaggcag    180

caatgaactt catcaagttc catcgaactg tgactgtcta aatggaggaa catgtgtgtc    240

caacaagtac ttctccaaca ttcactggtg caactgccca aagaaattcg gagggcagca    300

ctgtgaaata gataagtcaa aaacctgcta tgaggggaat ggtcactttt accgaggaaa    360

ggccagcact gacaccatgg gccggccctg cctgccctgg aactctgcca ctgtccttca    420

gcaaacgtac catgcccaca gatctgatgc tcttcagctg ggcctgggga aacataatta    480

ctgcaggaac ccagacaacc ggaggcgacc ctggtgctat gtgcaggtgg gcctaaagcc    540

gcttgtccaa gagtgcatgg tgcatgactg cgcagatgga aaaaagccct cctctcctcc    600

agaagaatta aaatttcagt gtggccaaaa gactctgagg ccccgcttta agattattgg    660

gggagaattc accaccatcg agaaccagcc ctggtttgcg gccatctaca ggaggcaccg    720

ggggggctct gtcacctacg tgtgtggagg cagcctcatc agcccttgct gggtgatcag    780

cgccacacac tgcttcattg attacccaaa gaaggaggac tacatcgtct acctgggtcg    840

ctcaaggctt aactccaaca cgcaagggga gatgaagttt gaggtggaaa acctcatcct    900

acacaaggac tacagcgctg acacgcttgc tcaccacaac gacattgcct tgctgaagat    960

ccgttccaag gagggcaggt gtgcgcagcc atcccggact atacagacca tctgcctgcc   1020

ctcgatgtat aacgatcccc agtttggcac aagctgtgag atcactggct ttggaaaaga   1080

gaattctacc gactatctct atccggagca gctgaaaatg actgttgtga agctgatttc   1140

ccaccgggag tgtcagcagc cccactacta cggctctgaa gtcaccacca aaatgctgtg   1200

tgctgctgac ccacagtgga aaacagattc ctgccaggga gactcagggg gacccctcgt   1260

ctgttccctc caaggccgca tgactttgac tggaattgtg agctggggcc gtggatgtgc   1320

cctgaaggac aagccaggcg tctacacgag agtctcacac ttcttaccct ggatccgcag   1380

tcacaccaag gaagagaatg gcctggccct ctgagggtcc ccagggagga aacgggcacc   1440

acccgctttc ttgctggttg tcatttttgc agtagagtca tctccatcag ctgtaagaag   1500

agactgggaa gataggctct gcacagatgg atttgcctgt gccacccacc agggcgaacg   1560

acaatagctt taccctcagg cataggcctg ggtgctggct gcccagaccc ctctggccag   1620

gatggagggg tggtcctgac tcaacatgtt actgaccagc aacttgtctt tttctggact   1680

gaagcctgca ggagttaaaa agggcagggc atctcctgtg catgggtgaa gggagagcca   1740

gctcccccga cggtgggcat ttgtgaggcc catggttgag aaatgaataa tttcccaatt   1800

aggaagtgta acagctgagg tctcttgagg gagcttagcc aatgtgggag cagcggtttg   1860

gggagcagag acactaacga cttcagggca gggctctgat attccatgaa tgtatcagga   1920

aatatatatg tgtgtgtatg tttgcacact tgtgtgtggg ctgtgagtgt aagtgtgagt   1980

aagagctggt gtctgattgt taagtctaaa tatttcctta aactgtgtgg actgtgatgc   2040

cacacagagt ggtctttctg gagaggttat aggtcactcc tggggcctct tgggtccccc   2100

acgtgacagt gcctgggaat gtattattct gcagcatgac ctgtgaccag cactgtctca   2160

gtttcacttt cacatagatg tccctttctt ggccagttat cccttccttt tagcctagtt   2220

catccaatcc tcactgggtg gggtgaggac cactcctgta cactgaatat ttatatttca   2280

ctatttttat ttatattttt gtaattttaa ataaaagtga tcaataaaat gtgatttttc   2340

tgatgaaaaa aaaaaaaaaa                                               2360


<210>  4
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Ala Leu Leu Ala Arg Leu Leu Leu Cys Val Leu Val Val Ser 
1               5                   10                  15      


Asp Ser Lys Gly Ser Asn Glu Leu His Gln Val Pro Ser Asn Cys Asp 
            20                  25                  30          


Cys Leu Asn Gly Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile 
        35                  40                  45              


His Trp Cys Asn Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile 
    50                  55                  60                  


Asp Lys Ser Lys Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly 
65                  70                  75                  80  


Lys Ala Ser Thr Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser 
                85                  90                  95      


Ala Thr Val Leu Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu 
            100                 105                 110         


Gln Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg 
        115                 120                 125             


Arg Arg Pro Trp Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln 
    130                 135                 140                 


Glu Cys Met Val His Asp Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Glu Glu Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg 
                165                 170                 175     


Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp 
            180                 185                 190         


Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val 
        195                 200                 205             


Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His 
    210                 215                 220                 


Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly 
225                 230                 235                 240 


Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val 
                245                 250                 255     


Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His 
            260                 265                 270         


His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys 
        275                 280                 285             


Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr 
    290                 295                 300                 


Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys 
305                 310                 315                 320 


Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val 
                325                 330                 335     


Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly 
            340                 345                 350         


Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys 
        355                 360                 365             


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu 
    370                 375                 380                 


Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys 
385                 390                 395                 400 


Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu 
                405                 410                 415     


Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
            420                 425                 430     


<210>  5
<211>  4314
<212>  DNA
<213>  Homo sapiens

<400>  5
cgagatcccg gggagccagc ttgctgggag agcgggacgg tccggagcaa gcccagaggc     60

agaggaggcg acagagggaa aaagggccga gctagccgct ccagtgctgt acaggagccg    120

aagggacgca ccacgccagc cccagcccgg ctccagcgac agccaacgcc tcttgcagcg    180

cggcggcttc gaagccgccg cccggagctg ccctttcctc ttcggtgaag tttttaaaag    240

ctgctaaaga ctcggaggaa gcaaggaaag tgcctggtag gactgacggc tgcctttgtc    300

ctcctcctct ccaccccgcc tccccccacc ctgccttccc cccctccccc gtcttctctc    360

ccgcagctgc ctcagtcggc tactctcagc caacccccct caccaccctt ctccccaccc    420

gcccccccgc ccccgtcggc ccagcgctgc cagcccgagt ttgcagagag gtaactccct    480

ttggctgcga gcgggcgagc tagctgcaca ttgcaaagaa ggctcttagg agccaggcga    540

ctggggagcg gcttcagcac tgcagccacg acccgcctgg ttaggctgca cgcggagaga    600

accctctgtt ttcccccact ctctctccac ctcctcctgc cttccccacc ccgagtgcgg    660

agccagagat caaaagatga aaaggcagtc aggtcttcag tagccaaaaa acaaaacaaa    720

caaaaacaaa aaagccgaaa taaaagaaaa agataataac tcagttctta tttgcaccta    780

cttcagtgga cactgaattt ggaaggtgga ggattttgtt tttttctttt aagatctggg    840

catcttttga atctaccctt caagtattaa gagacagact gtgagcctag cagggcagat    900

cttgtccacc gtgtgtcttc ttctgcacga gactttgagg ctgtcagagc gctttttgcg    960

tggttgctcc cgcaagtttc cttctctgga gcttcccgca ggtgggcagc tagctgcagc   1020

gactaccgca tcatcacagc ctgttgaact cttctgagca agagaagggg aggcggggta   1080

agggaagtag gtggaagatt cagccaagct caaggatgga agtgcagtta gggctgggaa   1140

gggtctaccc tcggccgccg tccaagacct accgaggagc tttccagaat ctgttccaga   1200

gcgtgcgcga agtgatccag aacccgggcc ccaggcaccc agaggccgcg agcgcagcac   1260

ctcccggcgc cagtttgctg ctgctgcagc agcagcagca gcagcagcag cagcagcagc   1320

agcagcagca gcagcagcag cagcagcagc agcaagagac tagccccagg cagcagcagc   1380

agcagcaggg tgaggatggt tctccccaag cccatcgtag aggccccaca ggctacctgg   1440

tcctggatga ggaacagcaa ccttcacagc cgcagtcggc cctggagtgc caccccgaga   1500

gaggttgcgt cccagagcct ggagccgccg tggccgccag caaggggctg ccgcagcagc   1560

tgccagcacc tccggacgag gatgactcag ctgccccatc cacgttgtcc ctgctgggcc   1620

ccactttccc cggcttaagc agctgctccg ctgaccttaa agacatcctg agcgaggcca   1680

gcaccatgca actccttcag caacagcagc aggaagcagt atccgaaggc agcagcagcg   1740

ggagagcgag ggaggcctcg ggggctccca cttcctccaa ggacaattac ttagggggca   1800

cttcgaccat ttctgacaac gccaaggagt tgtgtaaggc agtgtcggtg tccatgggcc   1860

tgggtgtgga ggcgttggag catctgagtc caggggaaca gcttcggggg gattgcatgt   1920

acgccccact tttgggagtt ccacccgctg tgcgtcccac tccttgtgcc ccattggccg   1980

aatgcaaagg ttctctgcta gacgacagcg caggcaagag cactgaagat actgctgagt   2040

attccccttt caagggaggt tacaccaaag ggctagaagg cgagagccta ggctgctctg   2100

gcagcgctgc agcagggagc tccgggacac ttgaactgcc gtctaccctg tctctctaca   2160

agtccggagc actggacgag gcagctgcgt accagagtcg cgactactac aactttccac   2220

tggctctggc cggaccgccg ccccctccgc cgcctcccca tccccacgct cgcatcaagc   2280

tggagaaccc gctggactac ggcagcgcct gggcggctgc ggcggcgcag tgccgctatg   2340

gggacctggc gagcctgcat ggcgcgggtg cagcgggacc cggttctggg tcaccctcag   2400

ccgccgcttc ctcatcctgg cacactctct tcacagccga agaaggccag ttgtatggac   2460

cgtgtggtgg tggtgggggt ggtggcggcg gcggcggcgg cggcggcggc ggcggcggcg   2520

gcggcggcgg cggcgaggcg ggagctgtag ccccctacgg ctacactcgg ccccctcagg   2580

ggctggcggg ccaggaaagc gacttcaccg cacctgatgt gtggtaccct ggcggcatgg   2640

tgagcagagt gccctatccc agtcccactt gtgtcaaaag cgaaatgggc ccctggatgg   2700

atagctactc cggaccttac ggggacatgc gtttggagac tgccagggac catgttttgc   2760

ccattgacta ttactttcca ccccagaaga cctgcctgat ctgtggagat gaagcttctg   2820

ggtgtcacta tggagctctc acatgtggaa gctgcaaggt cttcttcaaa agagccgctg   2880

aagggaaaca gaagtacctg tgcgccagca gaaatgattg cactattgat aaattccgaa   2940

ggaaaaattg tccatcttgt cgtcttcgga aatgttatga agcagggatg actctgggag   3000

cccggaagct gaagaaactt ggtaatctga aactacagga ggaaggagag gcttccagca   3060

ccaccagccc cactgaggag acaacccaga agctgacagt gtcacacatt gaaggctatg   3120

aatgtcagcc catctttctg aatgtcctgg aagccattga gccaggtgta gtgtgtgctg   3180

gacacgacaa caaccagccc gactcctttg cagccttgct ctctagcctc aatgaactgg   3240

gagagagaca gcttgtacac gtggtcaagt gggccaaggc cttgcctggc ttccgcaact   3300

tacacgtgga cgaccagatg gctgtcattc agtactcctg gatggggctc atggtgtttg   3360

ccatgggctg gcgatccttc accaatgtca actccaggat gctctacttc gcccctgatc   3420

tggttttcaa tgagtaccgc atgcacaagt cccggatgta cagccagtgt gtccgaatga   3480

ggcacctctc tcaagagttt ggatggctcc aaatcacccc ccaggaattc ctgtgcatga   3540

aagcactgct actcttcagc attattccag tggatgggct gaaaaatcaa aaattctttg   3600

atgaacttcg aatgaactac atcaaggaac tcgatcgtat cattgcatgc aaaagaaaaa   3660

atcccacatc ctgctcaaga cgcttctacc agctcaccaa gctcctggac tccgtgcagc   3720

ctattgcgag agagctgcat cagttcactt ttgacctgct aatcaagtca cacatggtga   3780

gcgtggactt tccggaaatg atggcagaga tcatctctgt gcaagtgccc aagatccttt   3840

ctgggaaagt caagcccatc tatttccaca cccagtgaag cattggaaac cctatttccc   3900

caccccagct catgccccct ttcagatgtc ttctgcctgt tataactctg cactactcct   3960

ctgcagtgcc ttggggaatt tcctctattg atgtacagtc tgtcatgaac atgttcctga   4020

attctatttg ctgggctttt tttttctctt tctctccttt ctttttcttc ttccctccct   4080

atctaaccct cccatggcac cttcagactt tgcttcccat tgtggctcct atctgtgttt   4140

tgaatggtgt tgtatgcctt taaatctgtg atgatcctca tatggcccag tgtcaagttg   4200

tgcttgttta cagcactact ctgtgccagc cacacaaacg tttacttatc ttatgccacg   4260

ggaagtttag agagctaaga ttatctgggg aaatcaaaac aaaaacaagc aaac         4314


<210>  6
<211>  920
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr 
                645                 650                 655     


Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala 
                725                 730                 735     


Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp 
            740                 745                 750         


Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp 
        755                 760                 765             


Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln 
    770                 775                 780                 


Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile 
785                 790                 795                 800 


Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile 
                805                 810                 815     


Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg 
            820                 825                 830         


Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys 
        835                 840                 845             


Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
    850                 855                 860                 


Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp 
865                 870                 875                 880 


Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met 
                885                 890                 895     


Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val 
            900                 905                 910         


Lys Pro Ile Tyr Phe His Thr Gln 
        915                 920 


<210>  7
<211>  1906
<212>  DNA
<213>  Homo sapiens

<400>  7
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct     60

tcctcaccct gtccgtgacg tggattggtg ctgcacccct catcctgtct cggattgtgg    120

gaggctggga gtgcgagaag cattcccaac cctggcaggt gcttgtggcc tctcgtggca    180

gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt cctcacagct gcccactgca    240

tcaggaacaa aagcgtgatc ttgctgggtc ggcacagcct gtttcatcct gaagacacag    300

gccaggtatt tcaggtcagc cacagcttcc cacacccgct ctacgatatg agcctcctga    360

agaatcgatt cctcaggcca ggtgatgact ccagccacga cctcatgctg ctccgcctgt    420

cagagcctgc cgagctcacg gatgctgtga aggtcatgga cctgcccacc caggagccag    480

cactggggac cacctgctac gcctcaggct ggggcagcat tgaaccagag gagttcttga    540

ccccaaagaa acttcagtgt gtggacctcc atgttatttc caatgacgtg tgtgcgcaag    600

ttcaccctca gaaggtgacc aagttcatgc tgtgtgctgg acgctggaca gggggcaaaa    660

gcacctgctc gtgggtcatt ctgatcaccg aactgaccat gccagccctg ccgatggtcc    720

tccatggctc cctagtgccc tggagaggag gtgtctagtc agagagtagt cctggaaggt    780

ggcctctgtg aggagccacg gggacagcat cctgcagatg gtcctggccc ttgtcccacc    840

gacctgtcta caaggactgt cctcgtggac cctcccctct gcacaggagc tggaccctga    900

agtcccttcc ccaccggcca ggactggagc ccctacccct ctgttggaat ccctgcccac    960

cttcttctgg aagtcggctc tggagacatt tctctcttct tccaaagctg ggaactgcta   1020

tctgttatct gcctgtccag gtctgaaaga taggattgcc caggcagaaa ctgggactga   1080

cctatctcac tctctccctg cttttaccct tagggtgatt ctgggggccc acttgtctgt   1140

aatggtgtgc ttcaaggtat cacgtcatgg ggcagtgaac catgtgccct gcccgaaagg   1200

ccttccctgt acaccaaggt ggtgcattac cggaagtgga tcaaggacac catcgtggcc   1260

aacccctgag cacccctatc aaccccctat tgtagtaaac ttggaacctt ggaaatgacc   1320

aggccaagac tcaagcctcc ccagttctac tgacctttgt ccttaggtgt gaggtccagg   1380

gttgctagga aaagaaatca gcagacacag gtgtagacca gagtgtttct taaatggtgt   1440

aattttgtcc tctctgtgtc ctggggaata ctggccatgc ctggagacat atcactcaat   1500

ttctctgagg acacagatag gatggggtgt ctgtgttatt tgtggggtac agagatgaaa   1560

gaggggtggg atccacactg agagagtgga gagtgacatg tgctggacac tgtccatgaa   1620

gcactgagca gaagctggag gcacaacgca ccagacactc acagcaagga tggagctgaa   1680

aacataaccc actctgtcct ggaggcactg ggaagcctag agaaggctgt gagccaagga   1740

gggagggtct tcctttggca tgggatgggg atgaagtaag gagagggact ggaccccctg   1800

gaagctgatt cactatgggg ggaggtgtat tgaagtcctc cagacaaccc tcagatttga   1860

tgatttccta gtagaactca cagaaataaa gagctgttat actgtg                  1906


<210>  8
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Trp Val Ile Leu Ile Thr Glu Leu Thr Met Pro Ala Leu Pro 
    210                 215                 220                 


Met Val Leu His Gly Ser Leu Val Pro Trp Arg Gly Gly Val 
225                 230                 235             


<210>  9
<211>  3963
<212>  DNA
<213>  Homo sapiens

<400>  9
attaaggact cggggcagga ggggcagaag ttgcgcgcag gccggcgggc gggagcggac     60

accgaggccg gcgtgcaggc gtgcgggtgt gcgggagccg ggctcggggg gatcggaccg    120

agagcgagaa gcgcggcatg gagctccagg cagcccgcgc ctgcttcgcc ctgctgtggg    180

gctgtgcgct ggccgcggcc gcggcggcgc agggcaagga agtggtactg ctggactttg    240

ctgcagctgg aggggagctc ggctggctca cacacccgta tggcaaaggg tgggacctga    300

tgcagaacat catgaatgac atgccgatct acatgtactc cgtgtgcaac gtgatgtctg    360

gcgaccagga caactggctc cgcaccaact gggtgtaccg aggagaggct gagcgtatct    420

tcattgagct caagtttact gtacgtgact gcaacagctt ccctggtggc gccagctcct    480

gcaaggagac tttcaacctc tactatgccg agtcggacct ggactacggc accaacttcc    540

agaagcgcct gttcaccaag attgacacca ttgcgcccga tgagatcacc gtcagcagcg    600

acttcgaggc acgccacgtg aagctgaacg tggaggagcg ctccgtgggg ccgctcaccc    660

gcaaaggctt ctacctggcc ttccaggata tcggtgcctg tgtggcgctg ctctccgtcc    720

gtgtctacta caagaagtgc cccgagctgc tgcagggcct ggcccacttc cctgagacca    780

tcgccggctc tgatgcacct tccctggcca ctgtggccgg cacctgtgtg gaccatgccg    840

tggtgccacc ggggggtgaa gagccccgta tgcactgtgc agtggatggc gagtggctgg    900

tgcccattgg gcagtgcctg tgccaggcag gctacgagaa ggtggaggat gcctgccagg    960

cctgctcgcc tggatttttt aagtttgagg catctgagag cccctgcttg gagtgccctg   1020

agcacacgct gccatcccct gagggtgcca cctcctgcga gtgtgaggaa ggcttcttcc   1080

gggcacctca ggacccagcg tcgatgcctt gcacacgacc cccctccgcc ccacactacc   1140

tcacagccgt gggcatgggt gccaaggtgg agctgcgctg gacgccccct caggacagcg   1200

ggggccgcga ggacattgtc tacagcgtca cctgcgaaca gtgctggccc gagtctgggg   1260

aatgcgggcc gtgtgaggcc agtgtgcgct actcggagcc tcctcacgga ctgacccgca   1320

ccagtgtgac agtgagcgac ctggagcccc acatgaacta caccttcacc gtggaggccc   1380

gcaatggcgt ctcaggcctg gtaaccagcc gcagcttccg tactgccagt gtcagcatca   1440

accagacaga gccccccaag gtgaggctgg agggccgcag caccacctcg cttagcgtct   1500

cctggagcat ccccccgccg cagcagagcc gagtgtggaa gtacgaggtc acttaccgca   1560

agaagggaga ctccaacagc tacaatgtgc gccgcaccga gggtttctcc gtgaccctgg   1620

acgacctggc cccagacacc acctacctgg tccaggtgca ggcactgacg caggagggcc   1680

agggggccgg cagcaaggtg cacgaattcc agacgctgtc cccggaggga tctggcaact   1740

tggcggtgat tggcggcgtg gctgtcggtg tggtcctgct tctggtgctg gcaggagttg   1800

gcttctttat ccaccgcagg aggaagaacc agcgtgcccg ccagtccccg gaggacgttt   1860

acttctccaa gtcagaacaa ctgaagcccc tgaagacata cgtggacccc cacacatatg   1920

aggaccccaa ccaggctgtg ttgaagttca ctaccgagat ccatccatcc tgtgtcactc   1980

ggcagaaggt gatcggagca ggagagtttg gggaggtgta caagggcatg ctgaagacat   2040

cctcggggaa gaaggaggtg ccggtggcca tcaagacgct gaaagccggc tacacagaga   2100

agcagcgagt ggacttcctc ggcgaggccg gcatcatggg ccagttcagc caccacaaca   2160

tcatccgcct agagggcgtc atctccaaat acaagcccat gatgatcatc actgagtaca   2220

tggagaatgg ggccctggac aagttccttc gggagaagga tggcgagttc agcgtgctgc   2280

agctggtggg catgctgcgg ggcatcgcag ctggcatgaa gtacctggcc aacatgaact   2340

atgtgcaccg tgacctggct gcccgcaaca tcctcgtcaa cagcaacctg gtctgcaagg   2400

tgtctgactt tggcctgtcc cgcgtgctgg aggacgaccc cgaggccacc tacaccacca   2460

gtggcggcaa gatccccatc cgctggaccg ccccggaggc catttcctac cggaagttca   2520

cctctgccag cgacgtgtgg agctttggca ttgtcatgtg ggaggtgatg acctatggcg   2580

agcggcccta ctgggagttg tccaaccacg aggtgatgaa agccatcaat gatggcttcc   2640

ggctccccac acccatggac tgcccctccg ccatctacca gctcatgatg cagtgctggc   2700

agcaggagcg tgcccgccgc cccaagttcg ctgacatcgt cagcatcctg gacaagctca   2760

ttcgtgcccc tgactccctc aagaccctgg ctgactttga cccccgcgtg tctatccggc   2820

tccccagcac gagcggctcg gagggggtgc ccttccgcac ggtgtccgag tggctggagt   2880

ccatcaagat gcagcagtat acggagcact tcatggcggc cggctacact gccatcgaga   2940

aggtggtgca gatgaccaac gacgacatca agaggattgg ggtgcggctg cccggccacc   3000

agaagcgcat cgcctacagc ctgctgggac tcaaggacca ggtgaacact gtggggatcc   3060

ccatctgagc ctcgacaggg cctggagccc catcggccaa gaatacttga agaaacagag   3120

tggcctccct gctgtgccat gctgggccac tggggacttt atttatttct agttctttcc   3180

tccccctgca acttccgctg aggggtctcg gatgacaccc tggcctgaac tgaggagatg   3240

accagggatg ctgggctggg ccctctttcc ctgcgagacg cacacagctg agcacttagc   3300

aggcaccgcc acgtcccagc atccctggag caggagcccc gccacagcct tcggacagac   3360

atataggata ttcccaagcc gaccttccct ccgccttctc ccacatgagg ccatctcagg   3420

agatggaggg cttggcccag cgccaagtaa acagggtacc tcaagcccca tttcctcaca   3480

ctaagagggc agactgtgaa cttgactggg tgagacccaa agcggtccct gtccctctag   3540

tgccttcttt agaccctcgg gccccatcct catccctgac tggccaaacc cttgctttcc   3600

tgggcctttg caagatgctt ggttgtgttg aggtttttaa atatatattt tgtactttgt   3660

ggagagaatg tgtgtgtgtg gcagggggcc ccgccagggc tggggacaga gggtgtcaaa   3720

cattcgtgag ctggggactc agggaccggt gctgcaggag tgtcctgccc atgccccagt   3780

cggccccatc tctcatcctt ttggataagt ttctattctg tcagtgttaa agattttgtt   3840

ttgttggaca tttttttcga atcttaattt attatttttt ttatatttat tgttagaaaa   3900

tgacttattt ctgctctgga ataaagttgc agatgattca aaccgaaaaa aaaaaaaaaa   3960

aaa                                                                 3963


<210>  10
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys 
1               5                   10                  15      


Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu 
            20                  25                  30          


Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr 
        35                  40                  45              


Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile 
    50                  55                  60                  


Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp 
65                  70                  75                  80  


Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile 
                85                  90                  95      


Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala 
            100                 105                 110         


Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu 
        115                 120                 125             


Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr 
    130                 135                 140                 


Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His 
145                 150                 155                 160 


Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys 
                165                 170                 175     


Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu 
            180                 185                 190         


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu 
        195                 200                 205             


Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala 
    210                 215                 220                 


Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly 
225                 230                 235                 240 


Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala 
            260                 265                 270         


Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser 
        275                 280                 285             


Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr 
                325                 330                 335     


Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln 
            340                 345                 350         


Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln 
        355                 360                 365             


Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg 
    370                 375                 380                 


Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser 
385                 390                 395                 400 


Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn 
                405                 410                 415     


Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val 
            420                 425                 430         


Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser 
        435                 440                 445             


Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser 
    450                 455                 460                 


Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn 
465                 470                 475                 480 


Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp 
                485                 490                 495     


Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln 
            500                 505                 510         


Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser 
        515                 520                 525             


Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly 
    530                 535                 540                 


Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg 
545                 550                 555                 560 


Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe 
                565                 570                 575     


Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His 
            580                 585                 590         


Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile 
        595                 600                 605             


His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe 
    610                 615                 620                 


Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln 
                645                 650                 655     


Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His 
            660                 665                 670         


His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met 
        675                 680                 685             


Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu 
    690                 695                 700                 


Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu 
705                 710                 715                 720 


Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val 
                725                 730                 735     


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val 
            740                 745                 750         


Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro 
        755                 760                 765             


Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr 
    770                 775                 780                 


Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val 
785                 790                 795                 800 


Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg 
                805                 810                 815     


Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp 
            820                 825                 830         


Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln 
        835                 840                 845             


Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe 
    850                 855                 860                 


Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser 
865                 870                 875                 880 


Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro 
                885                 890                 895     


Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp 
            900                 905                 910         


Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala 
        915                 920                 925             


Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile 
    930                 935                 940                 


Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr 
945                 950                 955                 960 


Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile 
                965                 970                 975     


<210>  11
<211>  2558
<212>  DNA
<213>  Homo sapiens

<400>  11
ttgtgctcct cgcttgcctg ttccttttcc acgcattttc caggataact gtgactccag     60

gcccgcaatg gatgccctgc aactagcaaa ttcggctttt gccgttgatc tgttcaaaca    120

actatgtgaa aaggagccac tgggcaatgt cctcttctct ccaatctgtc tctccacctc    180

tctgtcactt gctcaagtgg gtgctaaagg tgacactgca aatgaaattg gacaggttct    240

tcattttgaa aatgtcaaag atataccctt tggatttcaa acagtaacat cggatgtaaa    300

caaacttagt tccttttact cactgaaact aatcaagcgg ctctacgtag acaaatctct    360

gaatctttct acagagttca tcagctctac gaagagaccc tatgcaaagg aattggaaac    420

tgttgacttc aaagataaat tggaagaaac gaaaggtcag atcaacaact caattaagga    480

tctcacagat ggccactttg agaacatttt agctgacaac agtgtgaacg accagaccaa    540

aatccttgtg gttaatgctg cctactttgt tggcaagtgg atgaagaaat ttcctgaatc    600

agaaacaaaa gaatgtcctt tcagactcaa caagacagac accaaaccag tgcagatgat    660

gaacatggag gccacgttct gtatgggaaa cattgacagt atcaattgta agatcataga    720

gcttcctttt caaaataagc atctcagcat gttcatccta ctacccaagg atgtggagga    780

tgagtccaca ggcttggaga agattgaaaa acaactcaac tcagagtcac tgtcacagtg    840

gactaatccc agcaccatgg ccaatgccaa ggtcaaactc tccattccaa aatttaaggt    900

ggaaaagatg attgatccca aggcttgtct ggaaaatcta gggctgaaac atatcttcag    960

tgaagacaca tctgatttct ctggaatgtc agagaccaag ggagtggccc tatcaaatgt   1020

tatccacaaa gtgtgcttag aaataactga agatggtggg gattccatag aggtgccagg   1080

agcacggatc ctgcagcaca aggatgaatt gaatgctgac catcccttta tttacatcat   1140

caggcacaac aaaactcgaa acatcatttt ctttggcaaa ttctgttctc cttaagtggc   1200

atagcccatg ttaagtcctc cctgactttt ctgtggatgc cgatttctgt aaactctgca   1260

tccagagatt cattttctag atacaataaa ttgctaatgt tgctggatca ggaagccgcc   1320

agtacttgtc atatgtagcc ttcacacaga tagacctttt tttttttcca attctatctt   1380

ttgtttcctt ttttcccata agacaatgac atacgctttt aatgaaaagg aatcacgtta   1440

gaggaaaaat atttattcat tatttgtcaa attgtccggg gtagttggca gaaatacagt   1500

cttccacaaa gaaaattcct ataaggaaga tttggaagct cttcttccca gcactatgct   1560

ttccttcttt gggatagaga atgttccaga cattctcgct tccctgaaag actgaagaaa   1620

gtgtagtgca tgggacccac gaaactgccc tggctccagt gaaacttggg cacatgctca   1680

ggctactata ggtccagaag tccttatgtt aagccctggc aggcaggtgt ttattaaaat   1740

tctgaatttt ggggattttc aaaagataat attttacata cactgtatgt tatagaactt   1800

catggatcag atctggggca gcaacctata aatcaacacc ttaatatgct gcaacaaaat   1860

gtagaatatt cagacaaaat ggatacataa agactaagta gcccataagg ggtcaaaatt   1920

tgctgccaaa tgcgtatgcc accaacttac aaaaacactt cgttcgcaga gcttttcaga   1980

ttgtggaatg ttggataagg aattatagac ctctagtagc tgaaatgcaa gaccccaaga   2040

ggaagttcag atcttaatat aaattcactt tcatttttga tagctgtccc atctggtcat   2100

gtggttggca ctagactggt ggcaggggct tctagctgac tcgcacaggg attctcacaa   2160

tagccgatat cagaatttgt gttgaaggaa cttgtctctt catctaatat gatagcggga   2220

aaaggagagg aaactactgc ctttagaaaa tataagtaaa gtgattaaag tgctcacgtt   2280

accttgacac atagtttttc agtctatggg tttagttact ttagatggca agcatgtaac   2340

ttatattaat agtaatttgt aaagttgggt ggataagcta tccctgttgc cggttcatgg   2400

attacttctc tataaaaaat atatatttac caaaaaattt tgtgacattc cttctcccat   2460

ctcttccttg acatgcattg taaataggtt cttcttgttc tgagattcaa tattgaattt   2520

ctcctatgct attgacaata aaatattatt gaactacc                           2558


<210>  12
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Ala Leu Gln Leu Ala Asn Ser Ala Phe Ala Val Asp Leu Phe 
1               5                   10                  15      


Lys Gln Leu Cys Glu Lys Glu Pro Leu Gly Asn Val Leu Phe Ser Pro 
            20                  25                  30          


Ile Cys Leu Ser Thr Ser Leu Ser Leu Ala Gln Val Gly Ala Lys Gly 
        35                  40                  45              


Asp Thr Ala Asn Glu Ile Gly Gln Val Leu His Phe Glu Asn Val Lys 
    50                  55                  60                  


Asp Ile Pro Phe Gly Phe Gln Thr Val Thr Ser Asp Val Asn Lys Leu 
65                  70                  75                  80  


Ser Ser Phe Tyr Ser Leu Lys Leu Ile Lys Arg Leu Tyr Val Asp Lys 
                85                  90                  95      


Ser Leu Asn Leu Ser Thr Glu Phe Ile Ser Ser Thr Lys Arg Pro Tyr 
            100                 105                 110         


Ala Lys Glu Leu Glu Thr Val Asp Phe Lys Asp Lys Leu Glu Glu Thr 
        115                 120                 125             


Lys Gly Gln Ile Asn Asn Ser Ile Lys Asp Leu Thr Asp Gly His Phe 
    130                 135                 140                 


Glu Asn Ile Leu Ala Asp Asn Ser Val Asn Asp Gln Thr Lys Ile Leu 
145                 150                 155                 160 


Val Val Asn Ala Ala Tyr Phe Val Gly Lys Trp Met Lys Lys Phe Pro 
                165                 170                 175     


Glu Ser Glu Thr Lys Glu Cys Pro Phe Arg Leu Asn Lys Thr Asp Thr 
            180                 185                 190         


Lys Pro Val Gln Met Met Asn Met Glu Ala Thr Phe Cys Met Gly Asn 
        195                 200                 205             


Ile Asp Ser Ile Asn Cys Lys Ile Ile Glu Leu Pro Phe Gln Asn Lys 
    210                 215                 220                 


His Leu Ser Met Phe Ile Leu Leu Pro Lys Asp Val Glu Asp Glu Ser 
225                 230                 235                 240 


Thr Gly Leu Glu Lys Ile Glu Lys Gln Leu Asn Ser Glu Ser Leu Ser 
                245                 250                 255     


Gln Trp Thr Asn Pro Ser Thr Met Ala Asn Ala Lys Val Lys Leu Ser 
            260                 265                 270         


Ile Pro Lys Phe Lys Val Glu Lys Met Ile Asp Pro Lys Ala Cys Leu 
        275                 280                 285             


Glu Asn Leu Gly Leu Lys His Ile Phe Ser Glu Asp Thr Ser Asp Phe 
    290                 295                 300                 


Ser Gly Met Ser Glu Thr Lys Gly Val Ala Leu Ser Asn Val Ile His 
305                 310                 315                 320 


Lys Val Cys Leu Glu Ile Thr Glu Asp Gly Gly Asp Ser Ile Glu Val 
                325                 330                 335     


Pro Gly Ala Arg Ile Leu Gln His Lys Asp Glu Leu Asn Ala Asp His 
            340                 345                 350         


Pro Phe Ile Tyr Ile Ile Arg His Asn Lys Thr Arg Asn Ile Ile Phe 
        355                 360                 365             


Phe Gly Lys Phe Cys Ser Pro 
    370                 375 


<210>  13
<211>  2270
<212>  DNA
<213>  Homo sapiens

<400>  13
ctcctccagc ctctcacact ctcctcagct ctctcatctc ctggaaccat ggccagcaca     60

tccaccacca tcaggagcca cagcagcagc cgccggggtt tcagtgccaa ctcagccagg    120

ctccctgggg tcagccgctc tggcttcagc agcgtctccg tgtcccgctc caggggcagt    180

ggtggcctgg gtggtgcatg tggaggagct ggctttggca gccgcagtct gtatggcctg    240

gggggctcca agaggatctc cattggaggg ggcagctgtg ccatcagtgg cggctatggc    300

agcagagccg gaggcagcta tggctttggt ggcgccggga gtggatttgg tttcggtggt    360

ggagccggca ttggctttgg tctgggtggt ggagccggcc ttgctggtgg ctttgggggc    420

cctggcttcc ctgtgtgccc ccctggaggc atccaagagg tcaccgtcaa ccagagtctc    480

ctgactcccc tcaacctgca aatcgatccc accatccagc gggtgcgggc tgaggagcgt    540

gaacagatca agaccctcaa caacaagttt gcctccttca tcgacaaggt gcggttcctg    600

gagcagcaga acaaggttct ggaaacaaag tggaccctgc tgcaggagca gggcaccaag    660

actgtgaggc agaacctgga gccgttgttc gagcagtaca tcaacaacct caggaggcag    720

ctggacagca ttgtcgggga acggggccgc ctggactcag agctcagagg catgcaggac    780

ctggtggagg acttcaagaa caaatatgag gatgaaatca acaagcgcac agcagcagag    840

aatgaatttg tgactctgaa gaaggatgtg gatgctgcct acatgaacaa ggttgaactg    900

caagccaagg cagacactct cacagacgag atcaacttcc tgagagcctt gtatgatgca    960

gagctgtccc agatgcagac ccacatctca gacacatctg tggtgctgtc catggacaac   1020

aaccgcaacc tggacctgga cagcatcatc gctgaggtca aggcccaata tgaggagatt   1080

gctcagagaa gccgggctga ggctgagtcc tggtaccaga ccaagtacga ggagctgcag   1140

gtcacagcag gcagacatgg ggacgacctg cgcaacacca agcaggagat tgctgagatc   1200

aaccgcatga tccagaggct gagatctgag atcgaccacg tcaagaagca gtgcgccaac   1260

ctgcaggccg ccattgctga tgctgagcag cgtggggaga tggccctcaa ggatgccaag   1320

aacaagctgg aagggctgga ggatgccctg cagaaggcca agcaggacct ggcccggctg   1380

ctgaaggagt accaggagct gatgaatgtc aagctggccc tggacgtgga gatcgccacc   1440

taccgcaagc tgctggaggg tgaggagtgc aggctgaatg gcgaaggcgt tggacaagtc   1500

aacatctctg tggtgcagtc caccgtctcc agtggctatg gcggtgccag tggtgtcggc   1560

agtggcttag gcctgggtgg aggaagcagc tactcctatg gcagtggtct tggcgttgga   1620

ggtggcttca gttccagcag tggcagagcc attgggggtg gcctcagctc tgttggaggc   1680

ggcagttcca ccatcaagta caccaccacc tcctcctcca gcaggaagag ctataagcac   1740

taaagtgcgt ctgctagctc tcggtcccac agtcctcagg cccctctctg gctgcagagc   1800

cctctcctca ggttgcctgt cctctcctgg cctccagtct cccctgctgt cccaggtaga   1860

gctggggatg aatgcttagt gccctcactt cttctctctc tctctatacc atctgagcac   1920

ccattgctca ccatcagatc aacctctgat tttacatcat gatgtaatca ccactggagc   1980

ttcactgtta ctaaattatt aatttcttgc ctccagtgtt ctatctctga ggctgagcat   2040

tataagaaaa tgacctctgc tccttttcat tgcagaaaat tgccaggggc ttatttcaga   2100

acaacttcca cttactttcc actggctctc aaactctcta acttataagt gttgtgaacc   2160

cccacccagg cagtatccat gaaagcacaa gtgactagtc ctatgatgta caaagcctgt   2220

atctctgtga tgatttctgt gctcttcact gtttgcaatt gctaaataaa              2270


<210>  14
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Val Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Thr Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Glu 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Gly Met Gln Asp Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Val Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Ile Ser Val Val Gln Ser Thr Val Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Ile Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  15
<211>  2381
<212>  DNA
<213>  Homo sapiens

<400>  15
cactgaataa actctaggtt cccatttctt tcagccagat cctcccaggg aatcactaca     60

ggctggttag ccaaaaagtc ctgattttct gctcaataga ggtccttact ggaaggcagc    120

atgtccaatg ttaccttgag aaaaatgtct cccacaggaa atgagatgaa gagcaccact    180

cagggaacca cacggaagca gcaggatttt cacgaggtga acaaaagaag aactttctta    240

caggataaca gttggataaa gaaacgccct gaagaagaaa aagatgaaaa ttacggtagg    300

gtggtgctca accgacataa ttcccatgat gcattggaca ggaaagtaaa tgagagagat    360

gtgccaaaag ctacaattag tcggtacagt tctgatgaca ctttggacag gatctcagac    420

agaaatgatg ctgctaaaac atataaggcc aataccttgg ataaccaact aaccaatagg    480

agcatgtcca tgtttagatc actggaagta acaaagttgc aacctggcgg ttcattgaat    540

gccaacacct ccaacaccat agcatccact tctgctacta ctcctgtaaa gaagaagagg    600

cagtcctggt ttccaccgcc ccctccaggt tacaatgcct cttcgagcac aggaaccagg    660

agacgggaac caggtgttca ccctccaata cctccaaagc ccagttctcc tgtttcttct    720

cctaaccagc tgagacagga taataggcag atacatccac ctaaaccagg tgtatataca    780

gaaaccaaca gatctgctga aagaaatata agtgaagaat tggataatct catcaaaatg    840

aacaaaagct tgaataggaa tcaaggtctt gatagtctct tcagagcaaa tccaaaggta    900

gaagaaagag agaaaagagc caaaagcctt gaaagtctca tctatatgag tacccggaca    960

gataaagatg gcaaaggaat ccaaagcctt ggaagtccga ttaaagttaa tcaaaggact   1020

gacaaaaatg agaaaggaag acaaaatctc gaatctgttg ctaaagtgaa tgccaggatg   1080

aataaaacga gcagaagaag tgaagacctt gataatgcta ctgaagtaaa tcccaaagga   1140

catgaaaata ccactggaaa aaaagacctt gatgggctta ttaaagtgga tcctgaaaca   1200

aataaaaata ttacgagggg ccagagcctt gataatctca tcaaagtgac ccctgaagta   1260

aagagaagta accaaggttc caaagacctt aataacttca tcaaagtgta tccaggaaca   1320

gaaaaaagta ctgaaggggg ccaaagtctc gacagcctca ttaaagtgac tcctgaaaga   1380

aacagaacta accaagggaa ccaagacttg gaaaatctta tcaaagtgat cccttcagca   1440

aacaaaagca gtgaacaagg tcttgatgaa catattaatg tcagccccaa agctgtcaaa   1500

aacactgatg gaaaacaaga tcttgataaa ctcatcaagg tgaatcctga aattttcaca   1560

aacaaccaaa gaaaccaaga tcttgctaac ctcatcaaag taaatcctgc agtaatcaga   1620

aacaatcaga gccaagactt ggaaaatctt atcaaagtga tcccttcagc tcttagaaac   1680

actaatcgag accagaacct ggaaaattta attgaagtaa attctcatgt gtctgaaaac   1740

aagaatggaa gctctaacac tggagccaag caggcaggac cacaggatac tgttgtgtac   1800

acaaggacat atgtggagaa tagtaaatca cccaaggatg gatatcagga gaatatctct   1860

ggaaaataca tacaaactgt ttattcaact tctgataggt ctgtcattga aagagatatg   1920

tgcacttact gccgaaaacc cttgggtgta gaaactaaaa tgattttaga tgaattacaa   1980

atttgctgcc attctacttg ctttaagtgt gaaatatgca agcagccttt ggaaaatcta   2040

caagcgggtg atagtatttg gatttataga cagacaatac actgtgaacc ttgctactct   2100

aaaattatgg caaagtggat tccataactc tggcacaagg aaatcaagat gaaaagcact   2160

cattaaggaa ttaaagttac aagttttatc ttaataatat gtaatctaga aaagctttca   2220

cattgaagat caactcttgt acaaaattaa caattctgtt attgcataag taatctaatt   2280

gtcttcaata aggtcacaca cataaaaaga gccatctggt ctctggctag agttagcaat   2340

aaaaagttca aatggttcca gaaaaaaaaa aaaaaaaaaa a                       2381


<210>  16
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Asn Val Thr Leu Arg Lys Met Ser Pro Thr Gly Asn Glu Met 
1               5                   10                  15      


Lys Ser Thr Thr Gln Gly Thr Thr Arg Lys Gln Gln Asp Phe His Glu 
            20                  25                  30          


Val Asn Lys Arg Arg Thr Phe Leu Gln Asp Asn Ser Trp Ile Lys Lys 
        35                  40                  45              


Arg Pro Glu Glu Glu Lys Asp Glu Asn Tyr Gly Arg Val Val Leu Asn 
    50                  55                  60                  


Arg His Asn Ser His Asp Ala Leu Asp Arg Lys Val Asn Glu Arg Asp 
65                  70                  75                  80  


Val Pro Lys Ala Thr Ile Ser Arg Tyr Ser Ser Asp Asp Thr Leu Asp 
                85                  90                  95      


Arg Ile Ser Asp Arg Asn Asp Ala Ala Lys Thr Tyr Lys Ala Asn Thr 
            100                 105                 110         


Leu Asp Asn Gln Leu Thr Asn Arg Ser Met Ser Met Phe Arg Ser Leu 
        115                 120                 125             


Glu Val Thr Lys Leu Gln Pro Gly Gly Ser Leu Asn Ala Asn Thr Ser 
    130                 135                 140                 


Asn Thr Ile Ala Ser Thr Ser Ala Thr Thr Pro Val Lys Lys Lys Arg 
145                 150                 155                 160 


Gln Ser Trp Phe Pro Pro Pro Pro Pro Gly Tyr Asn Ala Ser Ser Ser 
                165                 170                 175     


Thr Gly Thr Arg Arg Arg Glu Pro Gly Val His Pro Pro Ile Pro Pro 
            180                 185                 190         


Lys Pro Ser Ser Pro Val Ser Ser Pro Asn Gln Leu Arg Gln Asp Asn 
        195                 200                 205             


Arg Gln Ile His Pro Pro Lys Pro Gly Val Tyr Thr Glu Thr Asn Arg 
    210                 215                 220                 


Ser Ala Glu Arg Asn Ile Ser Glu Glu Leu Asp Asn Leu Ile Lys Met 
225                 230                 235                 240 


Asn Lys Ser Leu Asn Arg Asn Gln Gly Leu Asp Ser Leu Phe Arg Ala 
                245                 250                 255     


Asn Pro Lys Val Glu Glu Arg Glu Lys Arg Ala Lys Ser Leu Glu Ser 
            260                 265                 270         


Leu Ile Tyr Met Ser Thr Arg Thr Asp Lys Asp Gly Lys Gly Ile Gln 
        275                 280                 285             


Ser Leu Gly Ser Pro Ile Lys Val Asn Gln Arg Thr Asp Lys Asn Glu 
    290                 295                 300                 


Lys Gly Arg Gln Asn Leu Glu Ser Val Ala Lys Val Asn Ala Arg Met 
305                 310                 315                 320 


Asn Lys Thr Ser Arg Arg Ser Glu Asp Leu Asp Asn Ala Thr Glu Val 
                325                 330                 335     


Asn Pro Lys Gly His Glu Asn Thr Thr Gly Lys Lys Asp Leu Asp Gly 
            340                 345                 350         


Leu Ile Lys Val Asp Pro Glu Thr Asn Lys Asn Ile Thr Arg Gly Gln 
        355                 360                 365             


Ser Leu Asp Asn Leu Ile Lys Val Thr Pro Glu Val Lys Arg Ser Asn 
    370                 375                 380                 


Gln Gly Ser Lys Asp Leu Asn Asn Phe Ile Lys Val Tyr Pro Gly Thr 
385                 390                 395                 400 


Glu Lys Ser Thr Glu Gly Gly Gln Ser Leu Asp Ser Leu Ile Lys Val 
                405                 410                 415     


Thr Pro Glu Arg Asn Arg Thr Asn Gln Gly Asn Gln Asp Leu Glu Asn 
            420                 425                 430         


Leu Ile Lys Val Ile Pro Ser Ala Asn Lys Ser Ser Glu Gln Gly Leu 
        435                 440                 445             


Asp Glu His Ile Asn Val Ser Pro Lys Ala Val Lys Asn Thr Asp Gly 
    450                 455                 460                 


Lys Gln Asp Leu Asp Lys Leu Ile Lys Val Asn Pro Glu Ile Phe Thr 
465                 470                 475                 480 


Asn Asn Gln Arg Asn Gln Asp Leu Ala Asn Leu Ile Lys Val Asn Pro 
                485                 490                 495     


Ala Val Ile Arg Asn Asn Gln Ser Gln Asp Leu Glu Asn Leu Ile Lys 
            500                 505                 510         


Val Ile Pro Ser Ala Leu Arg Asn Thr Asn Arg Asp Gln Asn Leu Glu 
        515                 520                 525             


Asn Leu Ile Glu Val Asn Ser His Val Ser Glu Asn Lys Asn Gly Ser 
    530                 535                 540                 


Ser Asn Thr Gly Ala Lys Gln Ala Gly Pro Gln Asp Thr Val Val Tyr 
545                 550                 555                 560 


Thr Arg Thr Tyr Val Glu Asn Ser Lys Ser Pro Lys Asp Gly Tyr Gln 
                565                 570                 575     


Glu Asn Ile Ser Gly Lys Tyr Ile Gln Thr Val Tyr Ser Thr Ser Asp 
            580                 585                 590         


Arg Ser Val Ile Glu Arg Asp Met Cys Thr Tyr Cys Arg Lys Pro Leu 
        595                 600                 605             


Gly Val Glu Thr Lys Met Ile Leu Asp Glu Leu Gln Ile Cys Cys His 
    610                 615                 620                 


Ser Thr Cys Phe Lys Cys Glu Ile Cys Lys Gln Pro Leu Glu Asn Leu 
625                 630                 635                 640 


Gln Ala Gly Asp Ser Ile Trp Ile Tyr Arg Gln Thr Ile His Cys Glu 
                645                 650                 655     


Pro Cys Tyr Ser Lys Ile Met Ala Lys Trp Ile Pro 
            660                 665             


<210>  17
<211>  4465
<212>  DNA
<213>  Homo sapiens

<400>  17
caattgtcat acgacttgca gtgagcgtca ggagcacgtc caggaactcc tcagcagcgc     60

ctccttcagc tccacagcca gacgccctca gacagcaaag cctacccccg cgccgcgccc    120

tgcccgccgc tcggatgctc gcccgcgccc tgctgctgtg cgcggtcctg gcgctcagcc    180

atacagcaaa tccttgctgt tcccacccat gtcaaaaccg aggtgtatgt atgagtgtgg    240

gatttgacca gtataagtgc gattgtaccc ggacaggatt ctatggagaa aactgctcaa    300

caccggaatt tttgacaaga ataaaattat ttctgaaacc cactccaaac acagtgcact    360

acatacttac ccacttcaag ggattttgga acgttgtgaa taacattccc ttccttcgaa    420

atgcaattat gagttatgtc ttgacatcca gatcacattt gattgacagt ccaccaactt    480

acaatgctga ctatggctac aaaagctggg aagccttctc taacctctcc tattatacta    540

gagcccttcc tcctgtgcct gatgattgcc cgactccctt gggtgtcaaa ggtaaaaagc    600

agcttcctga ttcaaatgag attgtggaaa aattgcttct aagaagaaag ttcatccctg    660

atccccaggg ctcaaacatg atgtttgcat tctttgccca gcacttcacg catcagtttt    720

tcaagacaga tcataagcga gggccagctt tcaccaacgg gctgggccat ggggtggact    780

taaatcatat ttacggtgaa actctggcta gacagcgtaa actgcgcctt ttcaaggatg    840

gaaaaatgaa atatcagata attgatggag agatgtatcc tcccacagtc aaagatactc    900

aggcagagat gatctaccct cctcaagtcc ctgagcatct acggtttgct gtggggcagg    960

aggtctttgg tctggtgcct ggtctgatga tgtatgccac aatctggctg cgggaacaca   1020

acagagtatg cgatgtgctt aaacaggagc atcctgaatg gggtgatgag cagttgttcc   1080

agacaagcag gctaatactg ataggagaga ctattaagat tgtgattgaa gattatgtgc   1140

aacacttgag tggctatcac ttcaaactga aatttgaccc agaactactt ttcaacaaac   1200

aattccagta ccaaaatcgt attgctgctg aatttaacac cctctatcac tggcatcccc   1260

ttctgcctga cacctttcaa attcatgacc agaaatacaa ctatcaacag tttatctaca   1320

acaactctat attgctggaa catggaatta cccagtttgt tgaatcattc accaggcaaa   1380

ttgctggcag ggttgctggt ggtaggaatg ttccacccgc agtacagaaa gtatcacagg   1440

cttccattga ccagagcagg cagatgaaat accagtcttt taatgagtac cgcaaacgct   1500

ttatgctgaa gccctatgaa tcatttgaag aacttacagg agaaaaggaa atgtctgcag   1560

agttggaagc actctatggt gacatcgatg ctgtggagct gtatcctgcc cttctggtag   1620

aaaagcctcg gccagatgcc atctttggtg aaaccatggt agaagttgga gcaccattct   1680

ccttgaaagg acttatgggt aatgttatat gttctcctgc ctactggaag ccaagcactt   1740

ttggtggaga agtgggtttt caaatcatca acactgcctc aattcagtct ctcatctgca   1800

ataacgtgaa gggctgtccc tttacttcat tcagtgttcc agatccagag ctcattaaaa   1860

cagtcaccat caatgcaagt tcttcccgct ccggactaga tgatatcaat cccacagtac   1920

tactaaaaga acgttcgact gaactgtaga agtctaatga tcatatttat ttatttatat   1980

gaaccatgtc tattaattta attatttaat aatatttata ttaaactcct tatgttactt   2040

aacatcttct gtaacagaag tcagtactcc tgttgcggag aaaggagtca tacttgtgaa   2100

gacttttatg tcactactct aaagattttg ctgttgctgt taagtttgga aaacagtttt   2160

tattctgttt tataaaccag agagaaatga gttttgacgt ctttttactt gaatttcaac   2220

ttatattata agaacgaaag taaagatgtt tgaatactta aacactatca caagatggca   2280

aaatgctgaa agtttttaca ctgtcgatgt ttccaatgca tcttccatga tgcattagaa   2340

gtaactaatg tttgaaattt taaagtactt ttggttattt ttctgtcatc aaacaaaaac   2400

aggtatcagt gcattattaa atgaatattt aaattagaca ttaccagtaa tttcatgtct   2460

actttttaaa atcagcaatg aaacaataat ttgaaatttc taaattcata gggtagaatc   2520

acctgtaaaa gcttgtttga tttcttaaag ttattaaact tgtacatata ccaaaaagaa   2580

gctgtcttgg atttaaatct gtaaaatcag atgaaatttt actacaattg cttgttaaaa   2640

tattttataa gtgatgttcc tttttcacca agagtataaa cctttttagt gtgactgtta   2700

aaacttcctt ttaaatcaaa atgccaaatt tattaaggtg gtggagccac tgcagtgtta   2760

tctcaaaata agaatatttt gttgagatat tccagaattt gtttatatgg ctggtaacat   2820

gtaaaatcta tatcagcaaa agggtctacc tttaaaataa gcaataacaa agaagaaaac   2880

caaattattg ttcaaattta ggtttaaact tttgaagcaa actttttttt atccttgtgc   2940

actgcaggcc tggtactcag attttgctat gaggttaatg aagtaccaag ctgtgcttga   3000

ataacgatat gttttctcag attttctgtt gtacagttta atttagcagt ccatatcaca   3060

ttgcaaaagt agcaatgacc tcataaaata cctcttcaaa atgcttaaat tcatttcaca   3120

cattaatttt atctcagtct tgaagccaat tcagtaggtg cattggaatc aagcctggct   3180

acctgcatgc tgttcctttt cttttcttct tttagccatt ttgctaagag acacagtctt   3240

ctcatcactt cgtttctcct attttgtttt actagtttta agatcagagt tcactttctt   3300

tggactctgc ctatattttc ttacctgaac ttttgcaagt tttcaggtaa acctcagctc   3360

aggactgcta tttagctcct cttaagaaga ttaaaagaga aaaaaaaagg cccttttaaa   3420

aatagtatac acttatttta agtgaaaagc agagaatttt atttatagct aattttagct   3480

atctgtaacc aagatggatg caaagaggct agtgcctcag agagaactgt acggggtttg   3540

tgactggaaa aagttacgtt cccattctaa ttaatgccct ttcttattta aaaacaaaac   3600

caaatgatat ctaagtagtt ctcagcaata ataataatga cgataatact tcttttccac   3660

atctcattgt cactgacatt taatggtact gtatattact taatttattg aagattatta   3720

tttatgtctt attaggacac tatggttata aactgtgttt aagcctacaa tcattgattt   3780

ttttttgtta tgtcacaatc agtatatttt ctttggggtt acctctctga atattatgta   3840

aacaatccaa agaaatgatt gtattaagat ttgtgaataa atttttagaa atctgattgg   3900

catattgaga tatttaaggt tgaatgtttg tccttaggat aggcctatgt gctagcccac   3960

aaagaatatt gtctcattag cctgaatgtg ccataagact gaccttttaa aatgttttga   4020

gggatctgtg gatgcttcgt taatttgttc agccacaatt tattgagaaa atattctgtg   4080

tcaagcactg tgggttttaa tatttttaaa tcaaacgctg attacagata atagtattta   4140

tataaataat tgaaaaaaat tttcttttgg gaagagggag aaaatgaaat aaatatcatt   4200

aaagataact caggagaatc ttctttacaa ttttacgttt agaatgttta aggttaagaa   4260

agaaatagtc aatatgcttg tataaaacac tgttcactgt tttttttaaa aaaaaaactt   4320

gatttgttat taacattgat ctgctgacaa aacctgggaa tttgggttgt gtatgcgaat   4380

gtttcagtgc ctcagacaaa tgtgtattta acttatgtaa aagataagtc tggaaataaa   4440

tgtctgttta tttttgtact attta                                         4465


<210>  18
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 
1               5                   10                  15      


Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 
            20                  25                  30          


Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 
                85                  90                  95      


Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser 
145                 150                 155                 160 


Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp 
                165                 170                 175     


Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 
            180                 185                 190         


His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn 
        195                 200                 205             


Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 
    210                 215                 220                 


Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr 
225                 230                 235                 240 


Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln 
                245                 250                 255     


Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala 
            260                 265                 270         


Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 
        275                 280                 285             


Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln 
    290                 295                 300                 


Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu 
305                 310                 315                 320 


Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln 
                325                 330                 335     


His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu 
            340                 345                 350         


Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn 
        355                 360                 365             


Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His 
    370                 375                 380                 


Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu 
385                 390                 395                 400 


Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile 
                405                 410                 415     


Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys 
            420                 425                 430         


Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser 
        435                 440                 445             


Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe 
    450                 455                 460                 


Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu 
                485                 490                 495     


Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly 
            500                 505                 510         


Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro 
        515                 520                 525             


Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile 
    530                 535                 540                 


Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly 
545                 550                 555                 560 


Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr 
                565                 570                 575     


Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn 
            580                 585                 590         


Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu 
        595                 600                 


<210>  19
<211>  970
<212>  DNA
<213>  Homo sapiens

<400>  19
ctcccctcac cccggtccag gatgcccagt ccccacgaca cctcccactt cccactgtgg     60

cctgggtggg ctcaggggct gcccttgacc tggcctagag ccctccccca gctggtggtg    120

gagctggcac tctctgggag ggagggggct gggagggaat gagtgggaat ggcaagaggc    180

cagggtttgg tgggatcagg ttgaggcagg tttggtttcc ttaaaatgcc aagttggggg    240

ccagtggggc ccacatataa atcctcaccc tgggagcctg gctgccttgc tctccttcct    300

gggtctgtct ctgccacctg gtctgccaca gatccatgat gtgcagttct ctggagcagg    360

cgctggctgt gctggtcact accttccaca agtactcctg ccaagagggc gacaagttca    420

agctgagtaa gggggaaatg aaggaacttc tgcacaagga gctgcccagc tttgtggggg    480

agaaagtgga tgaggagggg ctgaagaagc tgatgggcag cctggatgag aacagtgacc    540

agcaggtgga cttccaggag tatgctgttt tcctggcact catcactgtc atgtgcaatg    600

acttcttcca gggctgccca gaccgaccct gaagcagaac tcttgacttc ctgccatgga    660

tctcttgggc ccaggactgt tgatgccttt gagttttgta ttcaataaac tttttttgtc    720

tgttgataat attttaattg ctcagtgatg ttccataacc cggctggctc agctggagtg    780

ctgggagatg agggcctcct ggatcctgct cccttctggg ctctgactct cctggaaatc    840

tctccaaggc cagagctatg ctttaggtct caattttgga atttcaaaca ccagcaaaaa    900

attggaaatc gagataggtt gctgactttt attttgtcaa ataaagatat taaaaaaggc    960

aaaaaaaaaa                                                           970


<210>  20
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Cys Ser Ser Leu Glu Gln Ala Leu Ala Val Leu Val Thr Thr Phe 
1               5                   10                  15      


His Lys Tyr Ser Cys Gln Glu Gly Asp Lys Phe Lys Leu Ser Lys Gly 
            20                  25                  30          


Glu Met Lys Glu Leu Leu His Lys Glu Leu Pro Ser Phe Val Gly Glu 
        35                  40                  45              


Lys Val Asp Glu Glu Gly Leu Lys Lys Leu Met Gly Ser Leu Asp Glu 
    50                  55                  60                  


Asn Ser Asp Gln Gln Val Asp Phe Gln Glu Tyr Ala Val Phe Leu Ala 
65                  70                  75                  80  


Leu Ile Thr Val Met Cys Asn Asp Phe Phe Gln Gly Cys Pro Asp Arg 
                85                  90                  95      


Pro 
    


<210>  21
<211>  1753
<212>  DNA
<213>  Homo sapiens

<400>  21
cagccccgcc cctacctgtg gaagcccagc cgcccgctcc cgcggataaa aggcgcggag     60

tgtccccgag gtcagcgagt gcgcgctcct cctcgcccgc cgctaggtcc atcccggccc    120

agccaccatg tccatccact tcagctcccc ggtattcacc tcgcgctcag ccgccttctc    180

gggccgcggc gcccaggtgc gcctgagctc cgctcgcccc ggcggccttg gcagcagcag    240

cctctacggc ctcggcgcct cacggccgcg cgtggccgtg cgctctgcct atgggggccc    300

ggtgggcgcc ggcatccgcg aggtcaccat taaccagagc ctgctggccc cgctgcggct    360

ggacgccgac ccctccctcc agcgggtgcg ccaggaggag agcgagcaga tcaagaccct    420

caacaacaag tttgcctcct tcatcgacaa ggtgcggttt ctggagcagc agaacaagct    480

gctggagacc aagtggacgc tgctgcagga gcagaagtcg gccaagagca gccgcctccc    540

agacatcttt gaggcccaga ttgctggcct tcggggtcag cttgaggcac tgcaggtgga    600

tgggggccgc ctggaggcgg agctgcggag catgcaggat gtggtggagg acttcaagaa    660

taagtacgaa gatgaaatta accaccgcac agctgctgag aatgagtttg tggtgctgaa    720

gaaggatgtg gatgctgcct acatgagcaa ggtggagctg gaggccaagg tggatgccct    780

gaatgatgag atcaacttcc tcaggaccct caatgagacg gagttgacag agctgcagtc    840

ccagatctcc gacacatctg tggtgctgtc catggacaac agtcgctccc tggacctgga    900

cggcatcatc gctgaggtca aggcgcagta tgaggagatg gccaaatgca gccgggctga    960

ggctgaagcc tggtaccaga ccaagtttga gaccctccag gcccaggctg ggaagcatgg   1020

ggacgacctc cggaataccc ggaatgagat ttcagagatg aaccgggcca tccagaggct   1080

gcaggctgag atcgacaaca tcaagaacca gcgtgccaag ttggaggccg ccattgccga   1140

ggctgaggag cgtggggagc tggcgctcaa ggatgctcgt gccaagcagg aggagctgga   1200

agccgccctg cagcggggca agcaggatat ggcacggcag ctgcgtgagt accaggaact   1260

catgagcgtg aagctggccc tggacatcga gatcgccacc taccgcaagc tgctggaggg   1320

cgaggagagc cggttggctg gagatggagt gggagccgtg aatatctctg tgatgaattc   1380

cactggtggc agtagcagtg gcggtggcat tgggctgacc ctcgggggaa ccatgggcag   1440

caatgccctg agcttctcca gcagtgcggg tcctgggctc ctgaaggctt attccatccg   1500

gaccgcatcc gccagtcgca ggagtgcccg cgactgagcc gcctcccacc actccactcc   1560

tccagccacc acccacaatc acaagaagat tcccacccct gcctcccatg cctggtccca   1620

agacagtgag acagtctgga aagtgatgtc agaatagctt ccaataaagc agcctcattc   1680

tgaggcctga gtgatccacg tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1740

aaaaaaaaaa aaa                                                      1753


<210>  22
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Ile His Phe Ser Ser Pro Val Phe Thr Ser Arg Ser Ala Ala 
1               5                   10                  15      


Phe Ser Gly Arg Gly Ala Gln Val Arg Leu Ser Ser Ala Arg Pro Gly 
            20                  25                  30          


Gly Leu Gly Ser Ser Ser Leu Tyr Gly Leu Gly Ala Ser Arg Pro Arg 
        35                  40                  45              


Val Ala Val Arg Ser Ala Tyr Gly Gly Pro Val Gly Ala Gly Ile Arg 
    50                  55                  60                  


Glu Val Thr Ile Asn Gln Ser Leu Leu Ala Pro Leu Arg Leu Asp Ala 
65                  70                  75                  80  


Asp Pro Ser Leu Gln Arg Val Arg Gln Glu Glu Ser Glu Gln Ile Lys 
                85                  90                  95      


Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu 
            100                 105                 110         


Glu Gln Gln Asn Lys Leu Leu Glu Thr Lys Trp Thr Leu Leu Gln Glu 
        115                 120                 125             


Gln Lys Ser Ala Lys Ser Ser Arg Leu Pro Asp Ile Phe Glu Ala Gln 
    130                 135                 140                 


Ile Ala Gly Leu Arg Gly Gln Leu Glu Ala Leu Gln Val Asp Gly Gly 
145                 150                 155                 160 


Arg Leu Glu Ala Glu Leu Arg Ser Met Gln Asp Val Val Glu Asp Phe 
                165                 170                 175     


Lys Asn Lys Tyr Glu Asp Glu Ile Asn His Arg Thr Ala Ala Glu Asn 
            180                 185                 190         


Glu Phe Val Val Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Ser Lys 
        195                 200                 205             


Val Glu Leu Glu Ala Lys Val Asp Ala Leu Asn Asp Glu Ile Asn Phe 
    210                 215                 220                 


Leu Arg Thr Leu Asn Glu Thr Glu Leu Thr Glu Leu Gln Ser Gln Ile 
225                 230                 235                 240 


Ser Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp 
                245                 250                 255     


Leu Asp Gly Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Met Ala 
            260                 265                 270         


Lys Cys Ser Arg Ala Glu Ala Glu Ala Trp Tyr Gln Thr Lys Phe Glu 
        275                 280                 285             


Thr Leu Gln Ala Gln Ala Gly Lys His Gly Asp Asp Leu Arg Asn Thr 
    290                 295                 300                 


Arg Asn Glu Ile Ser Glu Met Asn Arg Ala Ile Gln Arg Leu Gln Ala 
305                 310                 315                 320 


Glu Ile Asp Asn Ile Lys Asn Gln Arg Ala Lys Leu Glu Ala Ala Ile 
                325                 330                 335     


Ala Glu Ala Glu Glu Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Ala 
            340                 345                 350         


Lys Gln Glu Glu Leu Glu Ala Ala Leu Gln Arg Gly Lys Gln Asp Met 
        355                 360                 365             


Ala Arg Gln Leu Arg Glu Tyr Gln Glu Leu Met Ser Val Lys Leu Ala 
    370                 375                 380                 


Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
385                 390                 395                 400 


Ser Arg Leu Ala Gly Asp Gly Val Gly Ala Val Asn Ile Ser Val Met 
                405                 410                 415     


Asn Ser Thr Gly Gly Ser Ser Ser Gly Gly Gly Ile Gly Leu Thr Leu 
            420                 425                 430         


Gly Gly Thr Met Gly Ser Asn Ala Leu Ser Phe Ser Ser Ser Ala Gly 
        435                 440                 445             


Pro Gly Leu Leu Lys Ala Tyr Ser Ile Arg Thr Ala Ser Ala Ser Arg 
    450                 455                 460                 


Arg Ser Ala Arg Asp 
465                 


<210>  23
<211>  1145
<212>  DNA
<213>  Homo sapiens

<400>  23
attctctccc cagcttgctg agccctttgc tcccctggcg actgcctgga cagtcagcaa     60

ggaattgtct cccagtgcat tttgccctcc tggctgccaa ctctggctgc taaagcggct    120

gccacctgct gcagtctaca cagcttcggg aagaggaaag gaacctcaga ccttccagat    180

cgcttcctct cgcaacaaac tatttgtcgc aggaataaag atggctgctg aaccagtaga    240

agacaattgc atcaactttg tggcaatgaa atttattgac aatacgcttt actttatagc    300

tgaagatgat gaaaacctgg aatcagatta ctttggcaag cttgaatcta aattatcagt    360

cataagaaat ttgaatgacc aagttctctt cattgaccaa ggaaatcggc ctctatttga    420

agatatgact gattctgact gtagagataa tgcaccccgg accatattta ttataagtat    480

gtataaagat agccagccta gaggtatggc tgtaactatc tctgtgaagt gtgagaaaat    540

ttcaactctc tcctgtgaga acaaaattat ttcctttaag gaaatgaatc ctcctgataa    600

catcaaggat acaaaaagtg acatcatatt ctttcagaga agtgtcccag gacatgataa    660

taagatgcaa tttgaatctt catcatacga aggatacttt ctagcttgtg aaaaagagag    720

agaccttttt aaactcattt tgaaaaaaga ggatgaattg ggggatagat ctataatgtt    780

cactgttcaa aacgaagact agctattaaa atttcatgcc gggcgcagtg gctcacgcct    840

gtaatcccag ccctttggga ggctgaggcg ggcagatcac cagaggtcag gtgttcaaga    900

ccagcctgac caacatggtg aaacctcatc tctactaaaa atacaaaaaa ttagctgagt    960

gtagtgacgc atgccctcaa tcccagctac tcaagaggct gaggcaggag aatcacttgc   1020

actccggagg tagaggttgt ggtgagccga gattgcacca ttgcgctcta gcctgggcaa   1080

caacagcaaa actccatctc aaaaaataaa ataaataaat aaacaaataa aaaattcata   1140

atgtg                                                               1145


<210>  24
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210>  25
<211>  1634
<212>  DNA
<213>  Homo sapiens

<400>  25
gggtggggaa gcttagagac cggtgaggga gcagagctgg ggcgcctgtg tacagggata     60

gagcccggcg gcagcagggc gcggcttccc tttcccgggg cctggggccg caatcaggtg    120

gagtcgagag gccggaggag gggcaggagg aaggggtgcg gtcgcgatcc ggacccggag    180

ccagcgcgga gcacctgcgc ccgcggctga caccttcgct cgcagtttgt tcgcagttta    240

ctcgcacacc agtttccccc accgcgcttt ggattagtgt gatctcagct caaggcaaag    300

gtgggatatc atggcatcta tctgggttgg acaccgagga acagtaagag attatccaga    360

ctttagccca tcagtggatg ctgaagctat tcagaaagca atcagaggaa ttggaactga    420

tgagaaaatg ctcatcagca ttctgactga gaggtcaaat gcacagcggc agctgattgt    480

taaggaatat caagcagcat atggaaagga gctgaaagat gacttgaagg gtgatctctc    540

tggccacttt gagcatctca tggtggccct agtgactcca ccagcagtct ttgatgcaaa    600

gcagctaaag aaatccatga agggcgcggg aacaaacgaa gatgccttga ttgaaatctt    660

aactaccagg acaagcaggc aaatgaagga tatctctcaa gcctattata cagtatacaa    720

gaagagtctt ggagatgaca ttagttccga aacatctggt gacttccgga aagctctgtt    780

gactttggca gatggcagaa gagatgaaag tctgaaagtg gatgagcatc tggccaaaca    840

agatgcccag attctctata aagctggtga gaacagatgg ggcacggatg aagacaaatt    900

cactgagatc ctgtgtttaa ggagctttcc tcaattaaaa ctaacatttg atgaatacag    960

aaatatcagc caaaaggaca ttgtggacag cataaaagga gaattatctg ggcattttga   1020

agacttactg ttggccatag ttaattgtgt gaggaacacg ccggcctttt tagccgaaag   1080

actgcatcga gccttgaagg gtattggaac tgatgagttt actctgaacc gaataatggt   1140

gtccagatca gaaattgacc ttttggacat tcgaacagag ttcaagaagc attatggcta   1200

ttccctatat tcagcaatta aatcggatac ttctggagac tatgaaatca cactcttaaa   1260

aatctgtggt ggagatgact gaaccaagaa gataatctcc aaaggtccac gatgggcttt   1320

cccaacagct ccaccttact tcttctcata ctatttaaga gaacaagcaa atataaacag   1380

caacttgtgt tcctaacagg aattttcatt gttctataac aacaacaaca aaagcgatta   1440

ttattttaga gcatctcatt tataatgtag cagctcataa atgaaattga aaatggtatt   1500

aaagatctgc aactactatc caacttatat ttctgctttc aaagttaaga atctttatag   1560

ttctactcca ttaaatataa agcaagataa taaaaattgt tgcttttgtt aaaagtaaaa   1620

aaaaaaaaaa aaaa                                                     1634


<210>  26
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp 
            


<210>  27
<211>  623
<212>  DNA
<213>  Homo sapiens

<400>  27
aggccaagct ggactgcata aagattggta tggccttagc tcttagccaa acaccttcct     60

gacaccatga gggccagcag cttcttgatc gtggtggtgt tcctcatcgc tgggacgctg    120

gttctagagg cagctgtcac gggagttcct gttaaaggtc aagacactgt caaaggccgt    180

gttccattca atggacaaga tcccgttaaa ggacaagttt cagttaaagg tcaagataaa    240

gtcaaagcgc aagagccagt caaaggtcca gtctccacta agcctggctc ctgccccatt    300

atcttgatcc ggtgcgccat gttgaatccc cctaaccgct gcttgaaaga tactgactgc    360

ccaggaatca agaagtgctg tgaaggctct tgcgggatgg cctgtttcgt tccccagtga    420

gagggagccg gtccttgctg cacctgtgcc gtccccagag ctacaggccc catctggtcc    480

taagtccctg ctgcccttcc ccttcccaca ctgtccattc ttcctcccat tcaggatgcc    540

cacggctgga gctgcctctc tcatccactt tccaataaag agttccttct gctccaaaaa    600

aaaaaaaaaa aaaaaaaaaa aaa                                            623


<210>  28
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Arg Ala Ser Ser Phe Leu Ile Val Val Val Phe Leu Ile Ala Gly 
1               5                   10                  15      


Thr Leu Val Leu Glu Ala Ala Val Thr Gly Val Pro Val Lys Gly Gln 
            20                  25                  30          


Asp Thr Val Lys Gly Arg Val Pro Phe Asn Gly Gln Asp Pro Val Lys 
        35                  40                  45              


Gly Gln Val Ser Val Lys Gly Gln Asp Lys Val Lys Ala Gln Glu Pro 
    50                  55                  60                  


Val Lys Gly Pro Val Ser Thr Lys Pro Gly Ser Cys Pro Ile Ile Leu 
65                  70                  75                  80  


Ile Arg Cys Ala Met Leu Asn Pro Pro Asn Arg Cys Leu Lys Asp Thr 
                85                  90                  95      


Asp Cys Pro Gly Ile Lys Lys Cys Cys Glu Gly Ser Cys Gly Met Ala 
            100                 105                 110         


Cys Phe Val Pro Gln 
        115         


<210>  29
<211>  1498
<212>  DNA
<213>  Homo sapiens

<400>  29
ttacattagc aagagagcaa gttgttccag tagttgcctg gcaggagaat ttgaaagggt     60

gccccaaagg acaatctcta aaggggtaag ggagatacct accttgtctg gtaggggaga    120

tgtttcgttt tcatgcttta ccagaaaatc cacttccctg ctgaccttag tttcaaagct    180

tattcttaat tagagacaag aaacctgttt caacttgaag acaccgtatg aggtgaatgg    240

acagccagcc accacaatga aagaaatcaa accaggaata acctatgctg aacccacgcc    300

tcaatcgtcc ccaagtgttt cctgacacgc atctttgctt acagtgcatc acaactgaag    360

aatggggttc aacttgacgc ttgcaaaatt accaaataac gagctgcacg gccaagagag    420

tcacaattca ggcaacagga gcgacgggcc aggaaagaac accacccttc acaatgaatt    480

tgacacaatt gtcttgccgg tgctttatct cattatattt gtggcaagca tcttgctgaa    540

tggtttagca gtgtggatct tcttccacat taggaataaa accagcttca tattctatct    600

caaaaacata gtggttgcag acctcataat gacgctgaca tttccatttc gaatagtcca    660

tgatgcagga tttggacctt ggtacttcaa gtttattctc tgcagataca cttcagtttt    720

gttttatgca aacatgtata cttccatcgt gttccttggg ctgataagca ttgatcgcta    780

tctgaaggtg gtcaagccat ttggggactc tcggatgtac aacataacct tcacgaaggt    840

tttatctgtt tgtgtttggg tgatcatggc tgttttgtct ttgccaaaca tcatcctgac    900

aaatggtcag ccaacagagg acaatatcca tgactgctca aaacttaaaa gtcctttggg    960

ggtcaaatgg catacggcag tcacctatgt gaacagctgc ttgtttgtgg ccgtgctggt   1020

gattctgatc ggatgttaca tagccatatc caggtacatc cacaaatcca gcaggcaatt   1080

cataagtcag tcaagccgaa agcgaaaaca taaccagagc atcagggttg ttgtggctgt   1140

gttttttacc tgctttctac catatcactt gtgcagaatt ccttttactt ttagtcactt   1200

agacaggctt ttagatgaat ctgcacaaaa aatcctatat tactgcaaag aaattacact   1260

tttcttgtct gcgtgtaatg tttgcctgga tccaataatt tactttttca tgtgtaggtc   1320

attttcaaga aggctgttca aaaaatcaaa tatcagaacc aggagtgaaa gcatcagatc   1380

actgcaaagt gtgagaagat cggaagttcg catatattat gattatactg atgtgtaggc   1440

cttttattgt ttgttggaat cgatatgtac aaagtgtaaa taaatgtttc ttttcatt     1498


<210>  30
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Phe Asn Leu Thr Leu Ala Lys Leu Pro Asn Asn Glu Leu His 
1               5                   10                  15      


Gly Gln Glu Ser His Asn Ser Gly Asn Arg Ser Asp Gly Pro Gly Lys 
            20                  25                  30          


Asn Thr Thr Leu His Asn Glu Phe Asp Thr Ile Val Leu Pro Val Leu 
        35                  40                  45              


Tyr Leu Ile Ile Phe Val Ala Ser Ile Leu Leu Asn Gly Leu Ala Val 
    50                  55                  60                  


Trp Ile Phe Phe His Ile Arg Asn Lys Thr Ser Phe Ile Phe Tyr Leu 
65                  70                  75                  80  


Lys Asn Ile Val Val Ala Asp Leu Ile Met Thr Leu Thr Phe Pro Phe 
                85                  90                  95      


Arg Ile Val His Asp Ala Gly Phe Gly Pro Trp Tyr Phe Lys Phe Ile 
            100                 105                 110         


Leu Cys Arg Tyr Thr Ser Val Leu Phe Tyr Ala Asn Met Tyr Thr Ser 
        115                 120                 125             


Ile Val Phe Leu Gly Leu Ile Ser Ile Asp Arg Tyr Leu Lys Val Val 
    130                 135                 140                 


Lys Pro Phe Gly Asp Ser Arg Met Tyr Asn Ile Thr Phe Thr Lys Val 
145                 150                 155                 160 


Leu Ser Val Cys Val Trp Val Ile Met Ala Val Leu Ser Leu Pro Asn 
                165                 170                 175     


Ile Ile Leu Thr Asn Gly Gln Pro Thr Glu Asp Asn Ile His Asp Cys 
            180                 185                 190         


Ser Lys Leu Lys Ser Pro Leu Gly Val Lys Trp His Thr Ala Val Thr 
        195                 200                 205             


Tyr Val Asn Ser Cys Leu Phe Val Ala Val Leu Val Ile Leu Ile Gly 
    210                 215                 220                 


Cys Tyr Ile Ala Ile Ser Arg Tyr Ile His Lys Ser Ser Arg Gln Phe 
225                 230                 235                 240 


Ile Ser Gln Ser Ser Arg Lys Arg Lys His Asn Gln Ser Ile Arg Val 
                245                 250                 255     


Val Val Ala Val Phe Phe Thr Cys Phe Leu Pro Tyr His Leu Cys Arg 
            260                 265                 270         


Ile Pro Phe Thr Phe Ser His Leu Asp Arg Leu Leu Asp Glu Ser Ala 
        275                 280                 285             


Gln Lys Ile Leu Tyr Tyr Cys Lys Glu Ile Thr Leu Phe Leu Ser Ala 
    290                 295                 300                 


Cys Asn Val Cys Leu Asp Pro Ile Ile Tyr Phe Phe Met Cys Arg Ser 
305                 310                 315                 320 


Phe Ser Arg Arg Leu Phe Lys Lys Ser Asn Ile Arg Thr Arg Ser Glu 
                325                 330                 335     


Ser Ile Arg Ser Leu Gln Ser Val Arg Arg Ser Glu Val Arg Ile Tyr 
            340                 345                 350         


Tyr Asp Tyr Thr Asp Val 
        355             


<210>  31
<211>  1270
<212>  DNA
<213>  Homo sapiens

<400>  31
agacgttcgc acacctgggt gccagcgccc cagaggtccc gggacagccc gaggcgccgc     60

gcccgccgcc ccgagctccc caagccttcg agagcggcgc acactcccgg tctccactcg    120

ctcttccaac acccgctcgt tttggcggca gctcgtgtcc cagagaccga gttgccccag    180

agaccgagac gccgccgctg cgaaggacca atgagagccc cgctgctacc gccggcgccg    240

gtggtgctgt cgctcttgat actcggctca ggccattatg ctgctggatt ggacctcaat    300

gacacctact ctgggaagcg tgaaccattt tctggggacc acagtgctga tggatttgag    360

gttacctcaa gaagtgagat gtcttcaggg agtgagattt cccctgtgag tgaaatgcct    420

tctagtagtg aaccgtcctc gggagccgac tatgactact cagaagagta tgataacgaa    480

ccacaaatac ctggctatat tgtcgatgat tcagtcagag ttgaacaggt agttaagccc    540

ccccaaaaca agacggaaag tgaaaatact tcagataaac ccaaaagaaa gaaaaaggga    600

ggcaaaaatg gaaaaaatag aagaaacaga aagaagaaaa atccatgtaa tgcagaattt    660

caaaatttct gcattcacgg agaatgcaaa tatatagagc acctggaagc agtaacatgc    720

aaatgtcagc aagaatattt cggtgaacgg tgtggggaaa agtccatgaa aactcacagc    780

atgattgaca gtagtttatc aaaaattgca ttagcagcca tagctgcctt tatgtctgct    840

gtgatcctca cagctgttgc tgttattaca gtccagctta gaagacaata cgtcaggaaa    900

tatgaaggag aagctgagga acgaaagaaa cttcgacaag agaatggaaa tgtacatgct    960

atagcataac tgaagataaa attacaggat atcacattgg agtcactgcc aagtcatagc   1020

cataaatgat gagtcggtcc tctttccagt ggatcataag acaatggacc ctttttgtta   1080

tgatggtttt aaactttcaa ttgtcacttt ttatgctatt tctgtatata aaggtgcacg   1140

aaggtaaaaa gtattttttc aagttgtaaa taatttattt aatatttaat ggaagtgtat   1200

ttattttaca gctcattaaa cttttttaac caaacagaaa aaaaaaaaaa aaaaaaaaaa   1260

aaaaaaaaaa                                                          1270


<210>  32
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Arg Ala Pro Leu Leu Pro Pro Ala Pro Val Val Leu Ser Leu Leu 
1               5                   10                  15      


Ile Leu Gly Ser Gly His Tyr Ala Ala Gly Leu Asp Leu Asn Asp Thr 
            20                  25                  30          


Tyr Ser Gly Lys Arg Glu Pro Phe Ser Gly Asp His Ser Ala Asp Gly 
        35                  40                  45              


Phe Glu Val Thr Ser Arg Ser Glu Met Ser Ser Gly Ser Glu Ile Ser 
    50                  55                  60                  


Pro Val Ser Glu Met Pro Ser Ser Ser Glu Pro Ser Ser Gly Ala Asp 
65                  70                  75                  80  


Tyr Asp Tyr Ser Glu Glu Tyr Asp Asn Glu Pro Gln Ile Pro Gly Tyr 
                85                  90                  95      


Ile Val Asp Asp Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln 
            100                 105                 110         


Asn Lys Thr Glu Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys 
        115                 120                 125             


Lys Gly Gly Lys Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn 
    130                 135                 140                 


Pro Cys Asn Ala Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys 
145                 150                 155                 160 


Tyr Ile Glu His Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr 
                165                 170                 175     


Phe Gly Glu Arg Cys Gly Glu Lys Ser Met Lys Thr His Ser Met Ile 
            180                 185                 190         


Asp Ser Ser Leu Ser Lys Ile Ala Leu Ala Ala Ile Ala Ala Phe Met 
        195                 200                 205             


Ser Ala Val Ile Leu Thr Ala Val Ala Val Ile Thr Val Gln Leu Arg 
    210                 215                 220                 


Arg Gln Tyr Val Arg Lys Tyr Glu Gly Glu Ala Glu Glu Arg Lys Lys 
225                 230                 235                 240 


Leu Arg Gln Glu Asn Gly Asn Val His Ala Ile Ala 
                245                 250         


<210>  33
<211>  1900
<212>  DNA
<213>  Homo sapiens

<400>  33
acaactctca gaggagcatt gcccgtcaga cagcaactca gagaataacc agagaacaac     60

cagattgaaa caatggagga tctttgtgtg gcaaacacac tctttgccct caatttattc    120

aagcatctgg caaaagcaag ccccacccag aacctcttcc tctccccatg gagcatctcg    180

tccaccatgg ccatggtcta catgggctcc aggggcagca ccgaagacca gatggccaag    240

gtgcttcagt ttaatgaagt gggagccaat gcagttaccc ccatgactcc agagaacttt    300

accagctgtg ggttcatgca gcagatccag aagggtagtt atcctgatgc gattttgcag    360

gcacaagctg cagataaaat ccattcatcc ttccgctctc tcagctctgc aatcaatgca    420

tccacaggga attatttact ggaaagtgtc aataagctgt ttggtgagaa gtctgcgagc    480

ttccgggaag aatatattcg actctgtcag aaatattact cctcagaacc ccaggcagta    540

gacttcctag aatgtgcaga agaagctaga aaaaagatta attcctgggt caagactcaa    600

accaaaggca aaatcccaaa cttgttacct gaaggttctg tagatgggga taccaggatg    660

gtcctggtga atgctgtcta cttcaaagga aagtggaaaa ctccatttga gaagaaacta    720

aatgggcttt atcctttccg tgtaaactcg gctcagcgca cacctgtaca gatgatgtac    780

ttgcgtgaaa agctaaacat tggatacata gaagacctaa aggctcagat tctagaactc    840

ccatatgctg gagatgttag catgttcttg ttgcttccag atgaaattgc cgatgtgtcc    900

actggcttgg agctgctgga aagtgaaata acctatgaca aactcaacaa gtggaccagc    960

aaagacaaaa tggctgaaga tgaagttgag gtatacatac cccagttcaa attagaagag   1020

cattatgaac tcagatccat tctgagaagc atgggcatgg aggacgcctt caacaaggga   1080

cgggccaatt tctcagggat gtcggagagg aatgacctgt ttctttctga agtgttccac   1140

caagccatgg tggatgtgaa tgaggagggc actgaagcag ccgctggcac aggaggtgtt   1200

atgacaggga gaactggaca tggaggccca cagtttgtgg cagatcatcc ttttcttttt   1260

cttattatgc ataagataac caactgcatt ttatttttcg gcagattttc ctcaccctaa   1320

aactaagcgt gctgcttctg caaaagattt ttgtagatga gctgtgtgcc tcagaattgc   1380

tatttcaaat tgccaaaaat ttagagatgt tttctacata tttctgctct tctgaacaac   1440

ttctgctacc cactaaataa aaacacagaa ataattagac aattgtctat tataacatga   1500

caaccctatt aatcatttgg tcttctaaaa tgggatcatg cccatttaga ttttccttac   1560

tatcagttta tttttataac attaactttt actttgttat ttattatttt atataatggt   1620

gagtttttaa attattgctc actgcctatt taatgtagct aataaagtta tagaagcaga   1680

tgatctgtta atttcctatc taataaatgc ctttaattgt tctcataatg aagaataagt   1740

aggtaccctc catgcccttc tgtaataaat atctggaaaa aacattaaac aataggcaaa   1800

tatatgttat gtgcatttct agaaatacat aacacatata tatgtctgta tcttatattc   1860

aattgcaagt atataataaa taaacctgct tccaaacaac                         1900


<210>  34
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Glu Asp Leu Cys Val Ala Asn Thr Leu Phe Ala Leu Asn Leu Phe 
1               5                   10                  15      


Lys His Leu Ala Lys Ala Ser Pro Thr Gln Asn Leu Phe Leu Ser Pro 
            20                  25                  30          


Trp Ser Ile Ser Ser Thr Met Ala Met Val Tyr Met Gly Ser Arg Gly 
        35                  40                  45              


Ser Thr Glu Asp Gln Met Ala Lys Val Leu Gln Phe Asn Glu Val Gly 
    50                  55                  60                  


Ala Asn Ala Val Thr Pro Met Thr Pro Glu Asn Phe Thr Ser Cys Gly 
65                  70                  75                  80  


Phe Met Gln Gln Ile Gln Lys Gly Ser Tyr Pro Asp Ala Ile Leu Gln 
                85                  90                  95      


Ala Gln Ala Ala Asp Lys Ile His Ser Ser Phe Arg Ser Leu Ser Ser 
            100                 105                 110         


Ala Ile Asn Ala Ser Thr Gly Asn Tyr Leu Leu Glu Ser Val Asn Lys 
        115                 120                 125             


Leu Phe Gly Glu Lys Ser Ala Ser Phe Arg Glu Glu Tyr Ile Arg Leu 
    130                 135                 140                 


Cys Gln Lys Tyr Tyr Ser Ser Glu Pro Gln Ala Val Asp Phe Leu Glu 
145                 150                 155                 160 


Cys Ala Glu Glu Ala Arg Lys Lys Ile Asn Ser Trp Val Lys Thr Gln 
                165                 170                 175     


Thr Lys Gly Lys Ile Pro Asn Leu Leu Pro Glu Gly Ser Val Asp Gly 
            180                 185                 190         


Asp Thr Arg Met Val Leu Val Asn Ala Val Tyr Phe Lys Gly Lys Trp 
        195                 200                 205             


Lys Thr Pro Phe Glu Lys Lys Leu Asn Gly Leu Tyr Pro Phe Arg Val 
    210                 215                 220                 


Asn Ser Ala Gln Arg Thr Pro Val Gln Met Met Tyr Leu Arg Glu Lys 
225                 230                 235                 240 


Leu Asn Ile Gly Tyr Ile Glu Asp Leu Lys Ala Gln Ile Leu Glu Leu 
                245                 250                 255     


Pro Tyr Ala Gly Asp Val Ser Met Phe Leu Leu Leu Pro Asp Glu Ile 
            260                 265                 270         


Ala Asp Val Ser Thr Gly Leu Glu Leu Leu Glu Ser Glu Ile Thr Tyr 
        275                 280                 285             


Asp Lys Leu Asn Lys Trp Thr Ser Lys Asp Lys Met Ala Glu Asp Glu 
    290                 295                 300                 


Val Glu Val Tyr Ile Pro Gln Phe Lys Leu Glu Glu His Tyr Glu Leu 
305                 310                 315                 320 


Arg Ser Ile Leu Arg Ser Met Gly Met Glu Asp Ala Phe Asn Lys Gly 
                325                 330                 335     


Arg Ala Asn Phe Ser Gly Met Ser Glu Arg Asn Asp Leu Phe Leu Ser 
            340                 345                 350         


Glu Val Phe His Gln Ala Met Val Asp Val Asn Glu Glu Gly Thr Glu 
        355                 360                 365             


Ala Ala Ala Gly Thr Gly Gly Val Met Thr Gly Arg Thr Gly His Gly 
    370                 375                 380                 


Gly Pro Gln Phe Val Ala Asp His Pro Phe Leu Phe Leu Ile Met His 
385                 390                 395                 400 


Lys Ile Thr Asn Cys Ile Leu Phe Phe Gly Arg Phe Ser Ser Pro 
                405                 410                 415 


<210>  35
<211>  4048
<212>  DNA
<213>  Homo sapiens

<400>  35
ggctgcctcg caggggctgc gcgcagcggc aagaagtgtc tgggctggga cggacaggag     60

aggctgtcgc catcggcgtc ctgtgcccct ctgctccggc acggccctgt cgcagtgccc    120

gcgctttccc cggcgcctgc acgcggcgcg cctgggtaac atgcttgggg tcctggtcct    180

tggcgcgctg gccctggccg gcctggggtt ccccgcaccc gcagagccgc agccgggtgg    240

cagccagtgc gtcgagcacg actgcttcgc gctctacccg ggccccgcga ccttcctcaa    300

tgccagtcag atctgcgacg gactgcgggg ccacctaatg acagtgcgct cctcggtggc    360

tgccgatgtc atttccttgc tactgaacgg cgacggcggc gttggccgcc ggcgcctctg    420

gatcggcctg cagctgccac ccggctgcgg cgaccccaag cgcctcgggc ccctgcgcgg    480

cttccagtgg gttacgggag acaacaacac cagctatagc aggtgggcac ggctcgacct    540

caatggggct cccctctgcg gcccgttgtg cgtcgctgtc tccgctgctg aggccactgt    600

gcccagcgag ccgatctggg aggagcagca gtgcgaagtg aaggccgatg gcttcctctg    660

cgagttccac ttcccagcca cctgcaggcc actggctgtg gagcccggcg ccgcggctgc    720

cgccgtctcg atcacctacg gcaccccgtt cgcggcccgc ggagcggact tccaggcgct    780

gccggtgggc agctccgccg cggtggctcc cctcggctta cagctaatgt gcaccgcgcc    840

gcccggagcg gtccaggggc actgggccag ggaggcgccg ggcgcttggg actgcagcgt    900

ggagaacggc ggctgcgagc acgcgtgcaa tgcgatccct ggggctcccc gctgccagtg    960

cccagccggc gccgccctgc aggcagacgg gcgctcctgc accgcatccg cgacgcagtc   1020

ctgcaacgac ctctgcgagc acttctgcgt tcccaacccc gaccagccgg gctcctactc   1080

gtgcatgtgc gagaccggct accggctggc ggccgaccaa caccggtgcg aggacgtgga   1140

tgactgcata ctggagccca gtccgtgtcc gcagcgctgt gtcaacacac agggtggctt   1200

cgagtgccac tgctacccta actacgacct ggtggacggc gagtgtgtgg agcccgtgga   1260

cccgtgcttc agagccaact gcgagtacca gtgccagccc ctgaaccaaa ctagctacct   1320

ctgcgtctgc gccgagggct tcgcgcccat tccccacgag ccgcacaggt gccagatgtt   1380

ttgcaaccag actgcctgtc cagccgactg cgaccccaac acccaggcta gctgtgagtg   1440

ccctgaaggc tacatcctgg acgacggttt catctgcacg gacatcgacg agtgcgaaaa   1500

cggcggcttc tgctccgggg tgtgccacaa cctccccggt accttcgagt gcatctgcgg   1560

gcccgactcg gcccttgccc gccacattgg caccgactgt gactccggca aggtggacgg   1620

tggcgacagc ggctctggcg agcccccgcc cagcccgacg cccggctcca ccttgactcc   1680

tccggccgtg gggctcgtgc attcgggctt gctcataggc atctccatcg cgagcctgtg   1740

cctggtggtg gcgcttttgg cgctcctctg ccacctgcgc aagaagcagg gcgccgccag   1800

ggccaagatg gagtacaagt gcgcggcccc ttccaaggag gtagtgctgc agcacgtgcg   1860

gaccgagcgg acgccgcaga gactctgagc ggcctccgtc caggagcctg gctccgtcca   1920

ggagcctgtg cctcctcacc cccagctttg ctaccaaagc accttagctg gcattacagc   1980

tggagaagac cctccccgca ccccccaagc tgttttcttc tattccatgg ctaactggcg   2040

agggggtgat tagagggagg agaatgagcc tcggcctctt ccgtgacgtc actggaccac   2100

tgggcaatga tggcaatttt gtaacgaaga cacagactgc gatttgtccc aggtcctcac   2160

taccgggcgc aggagggtga gcgttattgg tcggcagcct tctgggcaga ccttgacctc   2220

gtgggctagg gatgactaaa atatttattt tttttaagta tttaggtttt tgtttgtttc   2280

ctttgttctt acctgtatgt ctccagtatc cactttgcac agctctccgg tctctctctc   2340

tctacaaact cccacttgtc atgtgacagg taaactatct tggtgaattt ttttttccta   2400

gccctctcac atttatgaag caagccccac ttattcccca ttcttcctag ttttctcctc   2460

ccaggaactg ggccaactca cctgagtcac cctacctgtg cctgacccta cttcttttgc   2520

tcttagctgt ctgctcagac agaaccccta catgaaacag aaacaaaaac actaaaaata   2580

aaaatggcca tttgcttttt caccagattt gctaatttat cctgaaattt cagattccca   2640

gagcaaaata attttaaaca aaggttgaga tgtaaaaggt attaaattga tgttgctgga   2700

ctgtcataga aattacaccc aaagaggtat ttatctttac ttttaaacag tgagcctgaa   2760

ttttgttgct gttttgattt gtactgaaaa atggtaattg ttgctaatct tcttatgcaa   2820

tttccttttt tgttattatt acttattttt gacagtgttg aaaatgttca gaaggttgct   2880

ctagattgag agaagagaca aacacctccc aggagacagt tcaagaaagc ttcaaactgc   2940

atgattcatg ccaattagca attgactgtc actgttcctt gtcactggta gaccaaaata   3000

aaaccagctc tactggtctt gtggaattgg gagcttggga atggatcctg gaggatgccc   3060

aattagggcc tagccttaat caggtcctca gagaatttct accatttcag agaggccttt   3120

tggaatgtgg cccctgaaca agaattggaa gctgccctgc ccatgggagc tggttagaaa   3180

tgcagaatcc taggctccac cccatccagt tcatgagaat ctatatttaa caagatctgc   3240

agggggtgtg tctgctcagt aatttgagga caaccattcc agactgcttc caattttctg   3300

gaatacatga aatatagatc agttataagt agcaggccaa gtcaggccct tattttcaag   3360

aaactgagga attttctttg tgtagctttg ctctttggta gaaaaggcta ggtacacagc   3420

tctagacact gccacacagg gtctgcaagg tctttggttc agctaagcta ggaatgaaat   3480

cctgcttcag tgtatggaaa taaatgtatc atagaaatgt aacttttgta agacaaaggt   3540

tttcctcttc tattttgtaa actcaaaata tttgtacata gttatttatt tattggagat   3600

aatctagaac acaggcaaaa tccttgctta tgacatcact tgtacaaaat aaacaaataa   3660

caatgtgctc tcgggttgtg tgtctgttca cttttcctcc ctcagtgccc tcattttatg   3720

tcattaaatg gggctcacaa accatgcaaa tgctatgaga tgcatggagg gctgccctgt   3780

accccagcac ttgtgttgtc tggtggtggc accatctctg attttcaaag ctttttccag   3840

aggctattat tttcactgta gaatgatttc atgctatctc tgtgtgcaca aatatttatt   3900

ttctttctgt aaccataaca acttcatata tgaggacttg tgtctctgtg cttttaaatg   3960

cataaatgca ttataggatc atttgttgga atgaattaaa taaacccttc ctggggcatc   4020

tggcgaatcc caaaaaaaaa aaaaaaaa                                      4048


<210>  36
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
        35                  40                  45              


Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
65                  70                  75                  80  


Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                85                  90                  95      


Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
            100                 105                 110         


Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
        115                 120                 125             


Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
    130                 135                 140                 


Ala Thr Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val 
145                 150                 155                 160 


Lys Ala Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg 
                165                 170                 175     


Pro Leu Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr 
            180                 185                 190         


Tyr Gly Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro 
        195                 200                 205             


Val Gly Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys 
    210                 215                 220                 


Thr Ala Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro 
225                 230                 235                 240 


Gly Ala Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys 
                245                 250                 255     


Asn Ala Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala 
            260                 265                 270         


Leu Gln Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys 
        275                 280                 285             


Asn Asp Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly 
    290                 295                 300                 


Ser Tyr Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln 
305                 310                 315                 320 


His Arg Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys 
                325                 330                 335     


Pro Gln Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr 
            340                 345                 350         


Pro Asn Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro 
        355                 360                 365             


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
    370                 375                 380                 


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
385                 390                 395                 400 


Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
                405                 410                 415     


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
            420                 425                 430         


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
        435                 440                 445             


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
    450                 455                 460                 


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
465                 470                 475                 480 


Asp Ser Gly Lys Val Asp Gly Gly Asp Ser Gly Ser Gly Glu Pro Pro 
                485                 490                 495     


Pro Ser Pro Thr Pro Gly Ser Thr Leu Thr Pro Pro Ala Val Gly Leu 
            500                 505                 510         


Val His Ser Gly Leu Leu Ile Gly Ile Ser Ile Ala Ser Leu Cys Leu 
        515                 520                 525             


Val Val Ala Leu Leu Ala Leu Leu Cys His Leu Arg Lys Lys Gln Gly 
    530                 535                 540                 


Ala Ala Arg Ala Lys Met Glu Tyr Lys Cys Ala Ala Pro Ser Lys Glu 
545                 550                 555                 560 


Val Val Leu Gln His Val Arg Thr Glu Arg Thr Pro Gln Arg Leu 
                565                 570                 575 


<210>  37
<211>  627
<212>  DNA
<213>  Homo sapiens

<400>  37
gcggccgcaa gctcggcact cacggctctg agggctccga cggcactgac ggccatggcg     60

cgttcgaacc tcccgctggc gctgggcctg gccctggtcg cattctgcct cctggcgctg    120

ccacgcgacg cccgggcccg gccgcaggag cgcatggtcg gagaactccg ggacctgtcg    180

cccgacgacc cgcaggtgca gaaggcggcg caggcggccg tggccagcta caacatgggc    240

agcaacagca tctactactt ccgagacacg cacatcatca aggcgcagag ccagctggtg    300

gccggcatca agtacttcct gacgatggag atggggagca cagactgccg caagaccagg    360

gtcactggag accacgtcga cctcaccact tgccccctgg cagcaggggc gcagcaggag    420

aagctgcgct gtgactttga ggtccttgtg gttccctggc agaactcctc tcagctccta    480

aagcacaact gtgtgcagat gtgataagtc cccgagggcg aaggccattg ggtttggggc    540

catggtggag ggcacttcag gtccgtgggc cgtatctgtc acaataaatg gccagtgctg    600

cttcttgcaa aaaaaaaaaa aaaaaaa                                        627


<210>  38
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Arg Ser Asn Leu Pro Leu Ala Leu Gly Leu Ala Leu Val Ala 
1               5                   10                  15      


Phe Cys Leu Leu Ala Leu Pro Arg Asp Ala Arg Ala Arg Pro Gln Glu 
            20                  25                  30          


Arg Met Val Gly Glu Leu Arg Asp Leu Ser Pro Asp Asp Pro Gln Val 
        35                  40                  45              


Gln Lys Ala Ala Gln Ala Ala Val Ala Ser Tyr Asn Met Gly Ser Asn 
    50                  55                  60                  


Ser Ile Tyr Tyr Phe Arg Asp Thr His Ile Ile Lys Ala Gln Ser Gln 
65                  70                  75                  80  


Leu Val Ala Gly Ile Lys Tyr Phe Leu Thr Met Glu Met Gly Ser Thr 
                85                  90                  95      


Asp Cys Arg Lys Thr Arg Val Thr Gly Asp His Val Asp Leu Thr Thr 
            100                 105                 110         


Cys Pro Leu Ala Ala Gly Ala Gln Gln Glu Lys Leu Arg Cys Asp Phe 
        115                 120                 125             


Glu Val Leu Val Val Pro Trp Gln Asn Ser Ser Gln Leu Leu Lys His 
    130                 135                 140                 


Asn Cys Val Gln Met 
145                 


<210>  39
<211>  8972
<212>  DNA
<213>  Homo sapiens

<400>  39
cagctgccac ttttcaccgt tagaagtaga gctttttcca gacctcctac cttttagtct     60

actttgaaag gtgaaagaaa gaacatcgtt tcaggaataa aaatgcacag tagtagttat    120

agttaccgta gcagtgattc tgtgtttagt aacactacca gcactcgaac cagtcttgat    180

tcaaatgaaa atcttctctt ggttcattgt ggtccaacac tgatcaactc ttgcattagc    240

ttcggcagtg aatcctttga tggacacagg ttagaaatgt tgcaacagat tgccaacaga    300

gttcagaggg acagtgtcat ctgtgaagac aaactgattc ttgctggaaa tgctcttcag    360

tctgattcta aaagattaga atcaggagtg cagtttcaga atgaagcaga aattgctggg    420

tatatacttg aatgtgagaa ccttttacgc cagcatgtaa ttgatgtaca gattcttatt    480

gatggaaaat actaccaggc agatcaattg gtacagaggg ttgcaaaact gcgtgacgaa    540

attatggcct taaggaacga atgttcttct gtgtacagca aaggacgcat actgacaaca    600

gaacagacaa agctcatgat atcaggaatc actcaaagtt taaactcagg atttgcacag    660

accttacacc ctagtctgac ctcagggctg acccagagtt taacaccttc cctaacctct    720

tctagtatga cttctggcct gtcatcaggg atgacttccc gcctgactcc atctgtcact    780

ccagcttata cacctggttt cccatcagga ttagttccaa atttcagttc aggagtagag    840

ccaaattcat tgcaaacttt gaagttgatg cagatccgaa aaccccttct aaagtcttct    900

ttgctggatc aaaatttaac agaagaagaa atcaatatga aatttgttca ggatcttttg    960

aattgggttg atgagatgca ggtacaactg gaccgcactg agtggggctc agatttgcca   1020

agtgttgaaa gccatttaga aaatcataaa aatgttcata gagctattga agaatttgaa   1080

tctagtctca aagaagctaa aatcagtgag attcaaatga cagcacctct taaactgact   1140

tatgcagaaa agttgcacag attagagagt cagtatgcaa aactcttgaa tacatccagg   1200

aatcaagaac ggcaccttga tacactccat aattttgtaa gtcgtgcgac taatgaactt   1260

atttggttga atgaaaaaga agaggaggaa gttgcttatg actggagtga gagaaacacc   1320

aacatagcta ggaaaaaaga ttatcatgct gaattaatga gagaacttga tcaaaaggaa   1380

gaaaatatta aatcagttca ggagatagca gagcagctac ttctagaaaa tcatccagcc   1440

cggttaacta ttgaggccta cagagcggca atgcagacgc agtggagctg gatcttacag   1500

ctctgccagt gtgtggagca gcacataaag gagaacacag cgtatttcga gtttttcaat   1560

gatgccaaag aagctactga ttacttaagg aatctaaaag atgccattca gcggaagtac   1620

agctgtgata gatcaagcag cattcacaag ctagaagacc ttgttcagga atcaatggaa   1680

gagaaagaag aacttctgca gtacaaaagc actatagcaa acctaatggg aaaagcaaaa   1740

acaataattc aactgaagcc aaggaattct gactgtccac tcaaaacttc tattccgatc   1800

aaagctatct gtgactacag acaaattgag ataaccattt acaaagacga tgaatgtgtt   1860

ttggcgaata actctcatcg tgctaaatgg aaggtcatta gtcctactgg gaatgaggct   1920

atggtcccat ctgtgtgctt caccgttcct ccaccaaaca aagaagcggt ggaccttgcc   1980

aacagaattg agcaacagta tcagaatgtc ctgactcttt ggcatgagtc tcacataaac   2040

atgaagagtg tagtatcctg gcattatctc atcaatgaaa ttgatagaat tcgagctagc   2100

aatgtggctt caataaagac aatgctacct ggtgaacatc agcaagttct aagtaatcta   2160

caatctcgtt ttgaagattt tctggaagat agccaggaat cccaagtctt ttcaggctca   2220

gatataacac aactggaaaa ggaggttaat gtatgtaagc agtattatca agaacttctt   2280

aaatctgcag aaagagagga gcaagaggaa tcagtttata atctctacat ctctgaagtt   2340

cgaaacatta gacttcggtt agagaactgt gaagatcggc tgattagaca gattcgaact   2400

cccctggaaa gagatgattt gcatgaaagt gtgttcagaa tcacagaaca ggagaaacta   2460

aagaaagagc tggaacgact taaagatgat ttgggaacaa tcacaaataa gtgtgaggag   2520

tttttcagtc aagcagcagc ctcttcatca gtccctaccc tacgatcaga gcttaatgtg   2580

gtccttcaga acatgaacca agtctattct atgtcttcca cttacataga taagttgaaa   2640

actgttaact tggtgttaaa aaacactcaa gctgcagaag ccctcgtaaa actctatgaa   2700

actaaactgt gtgaagaaga agcagttata gctgacaaga ataatattga gaatctaata   2760

agtactttaa agcaatggag atctgaagta gatgaaaaga gacaggtatt ccatgcctta   2820

gaggatgagt tgcagaaagc taaagccatc agtgatgaaa tgtttaaaac gtataaagaa   2880

cgggaccttg attttgactg gcacaaagaa aaagcagatc aattagttga aaggtggcaa   2940

aatgttcatg tgcagattga caacaggtta cgggacttag agggcattgg caaatcactg   3000

aagtactaca gagacactta ccatccttta gatgattgga tccagcaggt tgaaactact   3060

cagagaaaga ttcaggaaaa tcagcctgaa aatagtaaaa ccctagccac acagttgaat   3120

caacagaaga tgctggtgtc cgaaatagaa atgaaacaga gcaaaatgga cgagtgtcaa   3180

aaatatgcag aacagtactc agctacagtg aaggactatg aattacaaac aatgacctac   3240

cgggccatgg tagattcaca acaaaaatct ccagtgaaac gccgaagaat gcagagttca   3300

gcagatctca ttattcaaga gttcatggac ctaaggactc gatatactgc cctggtcact   3360

ctcatgacac aatatattaa atttgctggt gattcattga agaggctgga agaggaggag   3420

attaaaaggt gtaaggagac ttctgaacat ggggcatatt cagatctgct tcagcgtcag   3480

aaggcaacag tgcttgagaa tagcaaactt acaggaaaga taagtgagtt ggaaagaatg   3540

gtagctgaac taaagaaaca aaagtcccga gtagaggaag aacttccgaa ggtcagggag   3600

gctgcagaaa atgaattgag aaagcagcag agaaatgtag aagatatctc tctgcagaag   3660

ataagggctg aaagtgaagc caagcagtac cgcagggaac ttgaaaccat tgtgagagag   3720

aaggaagccg ctgaaagaga actggagcgg gtgaggcagc tcaccataga ggccgaggct   3780

aaaagagctg ccgtggaaga gaacctcctg aattttcgca atcagttgga ggaaaacacc   3840

tttaccagac gaacactgga agatcatctt aaaagaaaag atttaagtct caatgatttg   3900

gagcaacaaa aaaataaatt aatggaagaa ttaagaagaa agagagacaa tgaggaagaa   3960

ctcttgaagc tgataaagca gatggaaaaa gaccttgcat ttcagaaaca ggtagcagag   4020

aaacagttga aagaaaagca gaaaattgaa ttggaagcaa gaagaaaaat aactgaaatt   4080

cagtatacat gtagagaaaa tgcattgcca gtgtgtccga tcacacaggc tacatcatgc   4140

agggcagtaa cgggtctcca gcaagaacat gacaagcaga aagcagaaga actcaaacag   4200

caggtagatg aactaacagc tgccaataga aaggctgaac aagacatgag agagctgaca   4260

tatgaactta atgccctcca gcttgaaaaa acgtcatctg aggaaaaggc tcgtttgcta   4320

aaagataaac tagatgaaac aaataataca ctcagatgcc ttaagttgga gctggaaagg   4380

aaggatcagg cggagaaagg gtattctcaa caactcagag agcttggtag gcaattgaat   4440

caaaccacag gtaaagctga agaagccatg caagaagcta gtgatctcaa gaaaataaag   4500

cgcaattatc agttagaatt agaatctctt aatcatgaaa aagggaaact acaaagagaa   4560

gtagacagaa tcacaagggc acatgctgta gctgagaaga atattcagca tttaaattca   4620

caaattcatt cttttcgaga tgagaaagaa ttagaaagac tacaaatctg ccagagaaaa   4680

tcagatcatc taaaagaaca atttgagaaa agccatgagc agttgcttca aaatatcaaa   4740

gctgaaaaag aaaataatga taaaatccaa aggctcaatg aagaattgga gaaaagtaat   4800

gagtgtgcag agatgctaaa acaaaaagta gaggagctta ctaggcagaa taatgaaacc   4860

aaattaatga tgcagagaat tcaggcagaa tcagagaata tagttttaga gaaacaaact   4920

atccagcaaa gatgtgaagc actgaaaatt caggcagatg gttttaaaga tcagctacgc   4980

agcacaaatg aacacttgca taaacagaca aaaacagagc aggattttca aagaaaaatt   5040

aaatgcctag aagaagacct ggcgaaaagt caaaatttgg taagtgaatt taagcaaaag   5100

tgtgaccaac agaacattat catccagaat accaagaaag aagttagaaa tctgaatgcg   5160

gaactgaatg cttccaaaga agagaagcga cgcggggagc agaaagttca gctacaacaa   5220

gctcaggtgc aagagttaaa taacaggttg aaaaaagtac aagacgaatt acacttaaag   5280

accatagagg agcagatgac ccacagaaag atggttctgt ttcaggaaga atctggtaaa   5340

ttcaaacaat cagcagagga gtttcggaag aagatggaaa aattaatgga gtccaaagtc   5400

atcactgaaa atgatatttc aggcattagg cttgactttg tgtctcttca acaagaaaac   5460

tctagagccc aagaaaatgc taagctttgt gaaacaaaca ttaaagaact tgaaagacag   5520

cttcaacagt atcgtgaaca aatgcagcaa gggcagcaca tggaagcaaa tcattaccaa   5580

aaatgtcaga aacttgagga tgagctgata gcccagaagc gtgaggttga aaacctgaag   5640

caaaaaatgg accaacagat caaagagcat gaacatcaat tagttttgct ccagtgtgaa   5700

attcaaaaaa agagcacagc caaagactgt accttcaaac cagattttga gatgacagtg   5760

aaggagtgcc agcactctgg agagctgtcc tctagaaaca ctggacacct tcacccaaca   5820

cccagatccc ctctgttgag atggactcaa gaaccacagc cattggaaga gaagtggcag   5880

catcgggttg ttgaacagat acccaaagaa gtccaattcc agccaccagg ggctccactc   5940

gagaaagaga aaagccagca gtgttactct gagtactttt ctcagacaag caccgagtta   6000

cagataactt ttgatgagac aaaccccatt acaagactgt ctgaaattga gaagataaga   6060

gaccaagccc tgaacaattc tagaccacct gttaggtatc aagataacgc atgtgaaatg   6120

gaactggtga aggttttgac acccttagag atagctaaga acaagcagta tgatatgcat   6180

acagaagtca caacattaaa acaagaaaag aacccagttc ccagtgctga agaatggatg   6240

cttgaagggt gcagagcatc tggtggactc aagaaagggg atttccttaa gaagggctta   6300

gaaccagaga ccttccagaa ctttgatggt gatcatgcat gttcagtcag ggatgatgaa   6360

tttaaattcc aagggcttag gcacactgtg actgccaggc agttggtgga agctaagctt   6420

ctggacatga gaacaattga gcagctgcga ctcggtctta agactgttga agaagttcag   6480

aaaactctta acaagtttct gacgaaagcc acctcaattg cagggcttta cctagaatct   6540

acaaaagaaa agatttcatt tgcctcagcg gccgagagaa tcataataga caaaatggtg   6600

gctttggcat ttttagaagc tcaggctgca acaggtttta taattgatcc catttcaggt   6660

cagacatatt ctgttgaaga tgcagttctt aaaggagttg ttgaccccga attcagaatt   6720

aggcttcttg aggcagagaa ggcagctgtg ggatattctt attcttctaa gacattgtca   6780

gtgtttcaag ctatggaaaa tagaatgctt gacagacaaa aaggtaaaca tatcttggaa   6840

gcccagattg ccagtggggg tgtcattgac cctgtgagag gcattcgtgt tcctccagaa   6900

attgctctgc agcaggggtt gttgaataat gccatcttac agtttttaca tgagccatcc   6960

agcaacacaa gagttttccc taatcccaat aacaagcaag ctctgtatta ctcagaatta   7020

ctgcgaatgt gtgtatttga tgtagagtcc caatgctttc tgtttccatt tggggagagg   7080

aacatttcca atctcaatgt caagaaaaca catagaattt ctgtagtaga tactaaaaca   7140

ggatcagaat tgaccgtgta tgaggctttc cagagaaacc tgattgagaa aagtatatat   7200

cttgaacttt cagggcagca atatcagtgg aaggaagcta tgttttttga atcctatggg   7260

cattcttctc atatgctgac tgatactaaa acaggattac acttcaatat taatgaggct   7320

atagagcagg gaacaattga caaagccttg gtcaaaaagt atcaggaagg cctcatcaca   7380

cttacagaac ttgctgattc tttgctgagc cggttagtcc ccaagaaaga tttgcacagt   7440

cctgttgcag ggtattggct gactgctagt ggggaaagga tctctgtact aaaagcctcc   7500

cgtagaaatt tggttgatcg gattactgcc ctccgatgcc ttgaagccca agtcagtaca   7560

gggggcataa ttgatcctct tactggcaaa aagtaccggg tggccgaagc tttgcataga   7620

ggcctggttg atgaggggtt tgcccagcag ctgcgacagt gtgaattagt aatcacaggg   7680

attggccatc ccatcactaa caaaatgatg tcagtggtgg aagctgtgaa tgcaaatatt   7740

ataaataagg aaatgggaat ccgatgtttg gaatttcagt acttgacagg agggttgata   7800

gagccacagg ttcactctcg gttatcaata gaagaggctc tccaagtagg tattatagat   7860

gtcctcattg ccacaaaact caaagatcaa aagtcatatg tcagaaatat aatatgccct   7920

cagacaaaaa gaaagttgac atataaagaa gccttagaaa aagctgattt tgatttccac   7980

acaggactta aactgttaga agtatctgag cccctgatga caggaatttc tagcctctac   8040

tattcttcct aatgggacat gtttaaataa ctgtgcaagg ggtgatgcag gctggttcat   8100

gccacttttt cagagtatga tgatatcggc tacatatgca gtctgtgaat tatgtaacat   8160

actctatttc ttgagggctg caaattgcta agtgctcaaa atagagtaag ttttaaattg   8220

aaaattacat aagatttaat gcccttcaaa tggtttcatt tagccttgag aatggttttt   8280

tgaaacttgg ccacactaaa atgttttttt ttttacgtag aatgtgggat aaacttgatg   8340

aactccaagt tcacagtgtc atttcttcag aactcccctt cattgaatag tgatcattta   8400

ttaaatgata aattgcactc gctgaaagag cacgtcatga agcaccatgg aatcaaagag   8460

aaagatataa attcgttccc acagccttca agctgcagtg ttttagattg cttcaaaaaa   8520

tgaaaaagtt ttgccttttt ctgtatatag tgaccttctt tgcatattaa aatgtttacc   8580

acaatgtccc atttctagtt aagtcttcgc acttgaaagc taacattatg aatattatgt   8640

gttggaggag gggaaggatt ttcttcattc tgtgtatttt ccttacatgt acagtagacg   8700

ttctctattc tatcagcctt ctatggtacc tttttgtcag gacaattagg attgtaatgc   8760

taatgcaaag gcagcaattc aaagatcttc tagtgcctca tgaataaagt tgagatttaa   8820

aatttgtaac attgatggaa cagctgggag gttagaccaa tcattaagga atgtatgcca   8880

tagctttctt tgctaccata aacattttgg aggtgcatct gctatgtgac atggtaaata   8940

tggttaagtg aatgaataaa atgttttagt aa                                 8972


<210>  40
<211>  2649
<212>  PRT
<213>  Homo sapiens

<400>  40

Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser 
1               5                   10                  15      


Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu 
            20                  25                  30          


Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly 
        35                  40                  45              


Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala 
    50                  55                  60                  


Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu 
65                  70                  75                  80  


Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val 
                85                  90                  95      


Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu 
            100                 105                 110         


Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly 
        115                 120                 125             


Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg 
    130                 135                 140                 


Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys 
145                 150                 155                 160 


Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile 
                165                 170                 175     


Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu 
            180                 185                 190         


Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser 
        195                 200                 205             


Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser 
    210                 215                 220                 


Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn 
225                 230                 235                 240 


Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met 
                245                 250                 255     


Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu 
            260                 265                 270         


Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp 
        275                 280                 285             


Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp 
    290                 295                 300                 


Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg 
305                 310                 315                 320 


Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu 
                325                 330                 335     


Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His 
            340                 345                 350         


Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln 
        355                 360                 365             


Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn 
    370                 375                 380                 


Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp 
385                 390                 395                 400 


Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala 
                405                 410                 415     


Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val 
            420                 425                 430         


Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu 
        435                 440                 445             


Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile 
    450                 455                 460                 


Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala 
465                 470                 475                 480 


Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg 
                485                 490                 495     


Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser 
            500                 505                 510         


Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys 
        515                 520                 525             


Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys 
    530                 535                 540                 


Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu 
545                 550                 555                 560 


Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu 
                565                 570                 575     


Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His 
            580                 585                 590         


Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val 
        595                 600                 605             


Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp 
    610                 615                 620                 


Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp 
625                 630                 635                 640 


His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu 
                645                 650                 655     


Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Ile Lys 
            660                 665                 670         


Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser 
        675                 680                 685             


Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser 
    690                 695                 700                 


Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln 
705                 710                 715                 720 


Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu 
                725                 730                 735     


Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg 
            740                 745                 750         


Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu 
        755                 760                 765             


Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu 
    770                 775                 780                 


Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile 
785                 790                 795                 800 


Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser 
                805                 810                 815     


Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn 
            820                 825                 830         


Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Leu Lys Thr Val 
        835                 840                 845             


Asn Leu Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu 
    850                 855                 860                 


Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn 
865                 870                 875                 880 


Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val 
                885                 890                 895     


Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys 
            900                 905                 910         


Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp 
        915                 920                 925             


Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg 
    930                 935                 940                 


Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu 
945                 950                 955                 960 


Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu 
                965                 970                 975     


Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu 
            980                 985                 990         


Asn Gln Pro Glu Asn Ser Lys Thr  Leu Ala Thr Gln Leu  Asn Gln Gln 
        995                 1000                 1005             


Lys Met  Leu Val Ser Glu Ile  Glu Met Lys Gln Ser  Lys Met Asp 
    1010                 1015                 1020             


Glu Cys  Gln Lys Tyr Ala Glu  Gln Tyr Ser Ala Thr  Val Lys Asp 
    1025                 1030                 1035             


Tyr Glu  Leu Gln Thr Met Thr  Tyr Arg Ala Met Val  Asp Ser Gln 
    1040                 1045                 1050             


Gln Lys  Ser Pro Val Lys Arg  Arg Arg Met Gln Ser  Ser Ala Asp 
    1055                 1060                 1065             


Leu Ile  Ile Gln Glu Phe Met  Asp Leu Arg Thr Arg  Tyr Thr Ala 
    1070                 1075                 1080             


Leu Val  Thr Leu Met Thr Gln  Tyr Ile Lys Phe Ala  Gly Asp Ser 
    1085                 1090                 1095             


Leu Lys  Arg Leu Glu Glu Glu  Glu Ile Lys Arg Cys  Lys Glu Thr 
    1100                 1105                 1110             


Ser Glu  His Gly Ala Tyr Ser  Asp Leu Leu Gln Arg  Gln Lys Ala 
    1115                 1120                 1125             


Thr Val  Leu Glu Asn Ser Lys  Leu Thr Gly Lys Ile  Ser Glu Leu 
    1130                 1135                 1140             


Glu Arg  Met Val Ala Glu Leu  Lys Lys Gln Lys Ser  Arg Val Glu 
    1145                 1150                 1155             


Glu Glu  Leu Pro Lys Val Arg  Glu Ala Ala Glu Asn  Glu Leu Arg 
    1160                 1165                 1170             


Lys Gln  Gln Arg Asn Val Glu  Asp Ile Ser Leu Gln  Lys Ile Arg 
    1175                 1180                 1185             


Ala Glu  Ser Glu Ala Lys Gln  Tyr Arg Arg Glu Leu  Glu Thr Ile 
    1190                 1195                 1200             


Val Arg  Glu Lys Glu Ala Ala  Glu Arg Glu Leu Glu  Arg Val Arg 
    1205                 1210                 1215             


Gln Leu  Thr Ile Glu Ala Glu  Ala Lys Arg Ala Ala  Val Glu Glu 
    1220                 1225                 1230             


Asn Leu  Leu Asn Phe Arg Asn  Gln Leu Glu Glu Asn  Thr Phe Thr 
    1235                 1240                 1245             


Arg Arg  Thr Leu Glu Asp His  Leu Lys Arg Lys Asp  Leu Ser Leu 
    1250                 1255                 1260             


Asn Asp  Leu Glu Gln Gln Lys  Asn Lys Leu Met Glu  Glu Leu Arg 
    1265                 1270                 1275             


Arg Lys  Arg Asp Asn Glu Glu  Glu Leu Leu Lys Leu  Ile Lys Gln 
    1280                 1285                 1290             


Met Glu  Lys Asp Leu Ala Phe  Gln Lys Gln Val Ala  Glu Lys Gln 
    1295                 1300                 1305             


Leu Lys  Glu Lys Gln Lys Ile  Glu Leu Glu Ala Arg  Arg Lys Ile 
    1310                 1315                 1320             


Thr Glu  Ile Gln Tyr Thr Cys  Arg Glu Asn Ala Leu  Pro Val Cys 
    1325                 1330                 1335             


Pro Ile  Thr Gln Ala Thr Ser  Cys Arg Ala Val Thr  Gly Leu Gln 
    1340                 1345                 1350             


Gln Glu  His Asp Lys Gln Lys  Ala Glu Glu Leu Lys  Gln Gln Val 
    1355                 1360                 1365             


Asp Glu  Leu Thr Ala Ala Asn  Arg Lys Ala Glu Gln  Asp Met Arg 
    1370                 1375                 1380             


Glu Leu  Thr Tyr Glu Leu Asn  Ala Leu Gln Leu Glu  Lys Thr Ser 
    1385                 1390                 1395             


Ser Glu  Glu Lys Ala Arg Leu  Leu Lys Asp Lys Leu  Asp Glu Thr 
    1400                 1405                 1410             


Asn Asn  Thr Leu Arg Cys Leu  Lys Leu Glu Leu Glu  Arg Lys Asp 
    1415                 1420                 1425             


Gln Ala  Glu Lys Gly Tyr Ser  Gln Gln Leu Arg Glu  Leu Gly Arg 
    1430                 1435                 1440             


Gln Leu  Asn Gln Thr Thr Gly  Lys Ala Glu Glu Ala  Met Gln Glu 
    1445                 1450                 1455             


Ala Ser  Asp Leu Lys Lys Ile  Lys Arg Asn Tyr Gln  Leu Glu Leu 
    1460                 1465                 1470             


Glu Ser  Leu Asn His Glu Lys  Gly Lys Leu Gln Arg  Glu Val Asp 
    1475                 1480                 1485             


Arg Ile  Thr Arg Ala His Ala  Val Ala Glu Lys Asn  Ile Gln His 
    1490                 1495                 1500             


Leu Asn  Ser Gln Ile His Ser  Phe Arg Asp Glu Lys  Glu Leu Glu 
    1505                 1510                 1515             


Arg Leu  Gln Ile Cys Gln Arg  Lys Ser Asp His Leu  Lys Glu Gln 
    1520                 1525                 1530             


Phe Glu  Lys Ser His Glu Gln  Leu Leu Gln Asn Ile  Lys Ala Glu 
    1535                 1540                 1545             


Lys Glu  Asn Asn Asp Lys Ile  Gln Arg Leu Asn Glu  Glu Leu Glu 
    1550                 1555                 1560             


Lys Ser  Asn Glu Cys Ala Glu  Met Leu Lys Gln Lys  Val Glu Glu 
    1565                 1570                 1575             


Leu Thr  Arg Gln Asn Asn Glu  Thr Lys Leu Met Met  Gln Arg Ile 
    1580                 1585                 1590             


Gln Ala  Glu Ser Glu Asn Ile  Val Leu Glu Lys Gln  Thr Ile Gln 
    1595                 1600                 1605             


Gln Arg  Cys Glu Ala Leu Lys  Ile Gln Ala Asp Gly  Phe Lys Asp 
    1610                 1615                 1620             


Gln Leu  Arg Ser Thr Asn Glu  His Leu His Lys Gln  Thr Lys Thr 
    1625                 1630                 1635             


Glu Gln  Asp Phe Gln Arg Lys  Ile Lys Cys Leu Glu  Glu Asp Leu 
    1640                 1645                 1650             


Ala Lys  Ser Gln Asn Leu Val  Ser Glu Phe Lys Gln  Lys Cys Asp 
    1655                 1660                 1665             


Gln Gln  Asn Ile Ile Ile Gln  Asn Thr Lys Lys Glu  Val Arg Asn 
    1670                 1675                 1680             


Leu Asn  Ala Glu Leu Asn Ala  Ser Lys Glu Glu Lys  Arg Arg Gly 
    1685                 1690                 1695             


Glu Gln  Lys Val Gln Leu Gln  Gln Ala Gln Val Gln  Glu Leu Asn 
    1700                 1705                 1710             


Asn Arg  Leu Lys Lys Val Gln  Asp Glu Leu His Leu  Lys Thr Ile 
    1715                 1720                 1725             


Glu Glu  Gln Met Thr His Arg  Lys Met Val Leu Phe  Gln Glu Glu 
    1730                 1735                 1740             


Ser Gly  Lys Phe Lys Gln Ser  Ala Glu Glu Phe Arg  Lys Lys Met 
    1745                 1750                 1755             


Glu Lys  Leu Met Glu Ser Lys  Val Ile Thr Glu Asn  Asp Ile Ser 
    1760                 1765                 1770             


Gly Ile  Arg Leu Asp Phe Val  Ser Leu Gln Gln Glu  Asn Ser Arg 
    1775                 1780                 1785             


Ala Gln  Glu Asn Ala Lys Leu  Cys Glu Thr Asn Ile  Lys Glu Leu 
    1790                 1795                 1800             


Glu Arg  Gln Leu Gln Gln Tyr  Arg Glu Gln Met Gln  Gln Gly Gln 
    1805                 1810                 1815             


His Met  Glu Ala Asn His Tyr  Gln Lys Cys Gln Lys  Leu Glu Asp 
    1820                 1825                 1830             


Glu Leu  Ile Ala Gln Lys Arg  Glu Val Glu Asn Leu  Lys Gln Lys 
    1835                 1840                 1845             


Met Asp  Gln Gln Ile Lys Glu  His Glu His Gln Leu  Val Leu Leu 
    1850                 1855                 1860             


Gln Cys  Glu Ile Gln Lys Lys  Ser Thr Ala Lys Asp  Cys Thr Phe 
    1865                 1870                 1875             


Lys Pro  Asp Phe Glu Met Thr  Val Lys Glu Cys Gln  His Ser Gly 
    1880                 1885                 1890             


Glu Leu  Ser Ser Arg Asn Thr  Gly His Leu His Pro  Thr Pro Arg 
    1895                 1900                 1905             


Ser Pro  Leu Leu Arg Trp Thr  Gln Glu Pro Gln Pro  Leu Glu Glu 
    1910                 1915                 1920             


Lys Trp  Gln His Arg Val Val  Glu Gln Ile Pro Lys  Glu Val Gln 
    1925                 1930                 1935             


Phe Gln  Pro Pro Gly Ala Pro  Leu Glu Lys Glu Lys  Ser Gln Gln 
    1940                 1945                 1950             


Cys Tyr  Ser Glu Tyr Phe Ser  Gln Thr Ser Thr Glu  Leu Gln Ile 
    1955                 1960                 1965             


Thr Phe  Asp Glu Thr Asn Pro  Ile Thr Arg Leu Ser  Glu Ile Glu 
    1970                 1975                 1980             


Lys Ile  Arg Asp Gln Ala Leu  Asn Asn Ser Arg Pro  Pro Val Arg 
    1985                 1990                 1995             


Tyr Gln  Asp Asn Ala Cys Glu  Met Glu Leu Val Lys  Val Leu Thr 
    2000                 2005                 2010             


Pro Leu  Glu Ile Ala Lys Asn  Lys Gln Tyr Asp Met  His Thr Glu 
    2015                 2020                 2025             


Val Thr  Thr Leu Lys Gln Glu  Lys Asn Pro Val Pro  Ser Ala Glu 
    2030                 2035                 2040             


Glu Trp  Met Leu Glu Gly Cys  Arg Ala Ser Gly Gly  Leu Lys Lys 
    2045                 2050                 2055             


Gly Asp  Phe Leu Lys Lys Gly  Leu Glu Pro Glu Thr  Phe Gln Asn 
    2060                 2065                 2070             


Phe Asp  Gly Asp His Ala Cys  Ser Val Arg Asp Asp  Glu Phe Lys 
    2075                 2080                 2085             


Phe Gln  Gly Leu Arg His Thr  Val Thr Ala Arg Gln  Leu Val Glu 
    2090                 2095                 2100             


Ala Lys  Leu Leu Asp Met Arg  Thr Ile Glu Gln Leu  Arg Leu Gly 
    2105                 2110                 2115             


Leu Lys  Thr Val Glu Glu Val  Gln Lys Thr Leu Asn  Lys Phe Leu 
    2120                 2125                 2130             


Thr Lys  Ala Thr Ser Ile Ala  Gly Leu Tyr Leu Glu  Ser Thr Lys 
    2135                 2140                 2145             


Glu Lys  Ile Ser Phe Ala Ser  Ala Ala Glu Arg Ile  Ile Ile Asp 
    2150                 2155                 2160             


Lys Met  Val Ala Leu Ala Phe  Leu Glu Ala Gln Ala  Ala Thr Gly 
    2165                 2170                 2175             


Phe Ile  Ile Asp Pro Ile Ser  Gly Gln Thr Tyr Ser  Val Glu Asp 
    2180                 2185                 2190             


Ala Val  Leu Lys Gly Val Val  Asp Pro Glu Phe Arg  Ile Arg Leu 
    2195                 2200                 2205             


Leu Glu  Ala Glu Lys Ala Ala  Val Gly Tyr Ser Tyr  Ser Ser Lys 
    2210                 2215                 2220             


Thr Leu  Ser Val Phe Gln Ala  Met Glu Asn Arg Met  Leu Asp Arg 
    2225                 2230                 2235             


Gln Lys  Gly Lys His Ile Leu  Glu Ala Gln Ile Ala  Ser Gly Gly 
    2240                 2245                 2250             


Val Ile  Asp Pro Val Arg Gly  Ile Arg Val Pro Pro  Glu Ile Ala 
    2255                 2260                 2265             


Leu Gln  Gln Gly Leu Leu Asn  Asn Ala Ile Leu Gln  Phe Leu His 
    2270                 2275                 2280             


Glu Pro  Ser Ser Asn Thr Arg  Val Phe Pro Asn Pro  Asn Asn Lys 
    2285                 2290                 2295             


Gln Ala  Leu Tyr Tyr Ser Glu  Leu Leu Arg Met Cys  Val Phe Asp 
    2300                 2305                 2310             


Val Glu  Ser Gln Cys Phe Leu  Phe Pro Phe Gly Glu  Arg Asn Ile 
    2315                 2320                 2325             


Ser Asn  Leu Asn Val Lys Lys  Thr His Arg Ile Ser  Val Val Asp 
    2330                 2335                 2340             


Thr Lys  Thr Gly Ser Glu Leu  Thr Val Tyr Glu Ala  Phe Gln Arg 
    2345                 2350                 2355             


Asn Leu  Ile Glu Lys Ser Ile  Tyr Leu Glu Leu Ser  Gly Gln Gln 
    2360                 2365                 2370             


Tyr Gln  Trp Lys Glu Ala Met  Phe Phe Glu Ser Tyr  Gly His Ser 
    2375                 2380                 2385             


Ser His  Met Leu Thr Asp Thr  Lys Thr Gly Leu His  Phe Asn Ile 
    2390                 2395                 2400             


Asn Glu  Ala Ile Glu Gln Gly  Thr Ile Asp Lys Ala  Leu Val Lys 
    2405                 2410                 2415             


Lys Tyr  Gln Glu Gly Leu Ile  Thr Leu Thr Glu Leu  Ala Asp Ser 
    2420                 2425                 2430             


Leu Leu  Ser Arg Leu Val Pro  Lys Lys Asp Leu His  Ser Pro Val 
    2435                 2440                 2445             


Ala Gly  Tyr Trp Leu Thr Ala  Ser Gly Glu Arg Ile  Ser Val Leu 
    2450                 2455                 2460             


Lys Ala  Ser Arg Arg Asn Leu  Val Asp Arg Ile Thr  Ala Leu Arg 
    2465                 2470                 2475             


Cys Leu  Glu Ala Gln Val Ser  Thr Gly Gly Ile Ile  Asp Pro Leu 
    2480                 2485                 2490             


Thr Gly  Lys Lys Tyr Arg Val  Ala Glu Ala Leu His  Arg Gly Leu 
    2495                 2500                 2505             


Val Asp  Glu Gly Phe Ala Gln  Gln Leu Arg Gln Cys  Glu Leu Val 
    2510                 2515                 2520             


Ile Thr  Gly Ile Gly His Pro  Ile Thr Asn Lys Met  Met Ser Val 
    2525                 2530                 2535             


Val Glu  Ala Val Asn Ala Asn  Ile Ile Asn Lys Glu  Met Gly Ile 
    2540                 2545                 2550             


Arg Cys  Leu Glu Phe Gln Tyr  Leu Thr Gly Gly Leu  Ile Glu Pro 
    2555                 2560                 2565             


Gln Val  His Ser Arg Leu Ser  Ile Glu Glu Ala Leu  Gln Val Gly 
    2570                 2575                 2580             


Ile Ile  Asp Val Leu Ile Ala  Thr Lys Leu Lys Asp  Gln Lys Ser 
    2585                 2590                 2595             


Tyr Val  Arg Asn Ile Ile Cys  Pro Gln Thr Lys Arg  Lys Leu Thr 
    2600                 2605                 2610             


Tyr Lys  Glu Ala Leu Glu Lys  Ala Asp Phe Asp Phe  His Thr Gly 
    2615                 2620                 2625             


Leu Lys  Leu Leu Glu Val Ser  Glu Pro Leu Met Thr  Gly Ile Ser 
    2630                 2635                 2640             


Ser Leu  Tyr Tyr Ser Ser 
    2645                 


<210>  41
<211>  3332
<212>  DNA
<213>  Homo sapiens

<400>  41
ctccctccag gaaggccgtt gtcttccctg ggacgacttg ccagctctga ggcatgacag     60

tacgggcccc cagaagggtg accaggaggc cctcctcgtc ccagctgccg gcgtcgccgc    120

ccactgcagg gcccgggctg tgactcgtgg ggacggttcc ctgcgccccg gcgggggagg    180

tgggcgggga ggggcggcgg ggcgccgggg cggggctcgg gacggccggg ctgggagctg    240

gagcccacag cgggaagcgg ccgccgcccg ggcctcgcag ggctaggcga ggcgaggggg    300

ggcggggccg ggcgctacgg gaaggggagg ccgcgcggac cgggagccgc accgcgccag    360

ccgggctgca gcggccgcgc accaaggctg cgatggggct ggagacggag aaggcggacg    420

tacagctctt catggacgac gactcctaca gccaccacag cggcctcgag tacgccgacc    480

ccgagaagtt cgcggactcg gaccaggacc gggatcccca ccggctcaac tcgcatctca    540

agctgggctt cgaggatgtg atcgcagagc cggtgactac gcactccttt gacaaagtgt    600

ggatctgcag ccatgccctc tttgaaatca gcaaatacgt aatgtacaag ttcctgacgg    660

tgttcctggc cattcccctg gccttcattg cgggaattct ctttgccacc ctcagctgtc    720

tgcacatctg gattttaatg ccttttgtaa agacctgcct aatggttctg ccttcagtgc    780

agacaatatg gaagagtgtg acagatgtta tcattgctcc attgtgtacg agcgtaggac    840

gatgcttctc ttctgtcagc ctgcaactga gccaggattg aatacttgga ccccaggtct    900

ggagattggg atactgtaat acttctttgt tattataaca taaaagcacc actgttctgt    960

tcatttccta gctgttctaa ttaagaaaac tattaagatg agcaaccaca tttagaaatg   1020

tttattgaca ggtcttttca aataatgctt ttctaattaa tagccaaaga tttcatatct   1080

aactttgtaa ccagaattat acagtaagtt gacaccactt agatttaaag gcagacagtt   1140

ttgctttagt acaatagtat acattttata atgatgaact tataatgatt aagggacatt   1200

tctataaaaa tactacaata gttttatgca caacttccca ttaaaaatga gatttcttat   1260

ttgtttgtct gtttttactc tgggagtaat actttttaaa ttacctttac atatatagtc   1320

actggcatac tgagaatata caatgatcct ggaaattgca gtaacaaaag cacacaacga   1380

ttatagtaac tataagatac aataaaacaa ataaatatga aagtagattc atgaaaatgt   1440

attcctttaa aatattgttt tcctacaggc ctatttaaca agatgtttca ttttactgta   1500

tattttgtag ttaatataaa tgttgctcta atcagattgc ttaaaagcat ttttattata   1560

tttatgttgt tgaactaata tatgaaataa gtaaatgtag ctcccacaag gtaaacttca   1620

ttggtaagat tgcactgttc tgattatgta agcatttgta catcttcttt ggaaataaaa   1680

gataaaagag cgatacacaa agctttcttt tctaactttt ccaagcaaaa tctaaaatgt   1740

tttatgacat ttttctggct gtgatcttaa aataattcat atctaaatag tattttgtct   1800

aggagatgct ttctctctag tagttagaaa ttaaatctgt gtcagcattc ctattaatgt   1860

ctcactttac tttcaagtaa tattggtgct atttaacatt ttacagtaaa tgttacttct   1920

gatactttag tacaatttca actacagtga ttcatgtaga gagacagggg agttgtcaac   1980

ttgggctact gaactacatg cataaactaa aaactaacag ctacaaactt ttaagatttc   2040

tctaatattg gtatgtaaca caggataaag ttattcttgt cattttgaac tgtagagtcc   2100

tatttcagtg tgatgaatca ctgttgcttt gaaaaatctc attatttctg ggccgggcat   2160

ggtggctcac ccctgtaatc ccagcacttt gggaggccaa ggcgggtgga tcatgaggtc   2220

aggagatcaa gaccatcctg gccaacatgg tgataccccg tctctactaa aaatacaaaa   2280

aaattagttg ggcatggtgg catgcacctg tagtcccagc tacctgggag gctgaggcag   2340

gagaattgct tgaacctggg aggcagaggt tgcagtgagc caaaatcatg ccactgcact   2400

cccgcctggc aacagagcaa gagtctgtct caaaaaaaaa aagaaaaaaa gaaaaaaaga   2460

aaaaagaaaa atctcattat ttcaaaatga tagacatata ccaaaaacaa gtctataatg   2520

tgagtagtta ctaaaattta cacatcttaa aagtgtgtaa atgcttaaat ttcagaatta   2580

ccatcagaac ctcaattgac attcctttga atacgctaat aagtgacaaa taagattaat   2640

aagatttttc aaaatcgcca ggactggtga atataaatga tgattgaact ggaataatat   2700

tggggaccaa atcaaatgaa tgattaaatt atgaagctca tatccttttg aaggtagttg   2760

caaagagaca tttcaaaact gccctaggcc attgcagcat ccttagatgg gacgcataat   2820

cattacctta aagcatcacc actcattttg accatataga ttttattatg ttagtttaaa   2880

aggtcaatca gcctcatgac tttatagtta tgtcttgtat ttaaaaacat tttttataca   2940

tttggttatg ttgataaacc aaaaacattt gattaataaa atatctattt gaataaatta   3000

tgagctatcc tttcaaacag ctattggcaa gttttaaacc caaaatatat acacatagtt   3060

ctgtaataaa actgtttgac ttctcaagta acatgacttc cttatttctg aacagtactg   3120

gttactttca aaatgaattt ttattgagat tttccattaa ctattttttt caaagactca   3180

aattttgtac caagtaaatc caggctttat gtacaaacat gttgtttgtt ttatttgggg   3240

ctgggggagg tatatgatga gcagacttct cggaattcat aataaatttt ctaaaagcct   3300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                 3332


<210>  42
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gly Leu Glu Thr Glu Lys Ala Asp Val Gln Leu Phe Met Asp Asp 
1               5                   10                  15      


Asp Ser Tyr Ser His His Ser Gly Leu Glu Tyr Ala Asp Pro Glu Lys 
            20                  25                  30          


Phe Ala Asp Ser Asp Gln Asp Arg Asp Pro His Arg Leu Asn Ser His 
        35                  40                  45              


Leu Lys Leu Gly Phe Glu Asp Val Ile Ala Glu Pro Val Thr Thr His 
    50                  55                  60                  


Ser Phe Asp Lys Val Trp Ile Cys Ser His Ala Leu Phe Glu Ile Ser 
65                  70                  75                  80  


Lys Tyr Val Met Tyr Lys Phe Leu Thr Val Phe Leu Ala Ile Pro Leu 
                85                  90                  95      


Ala Phe Ile Ala Gly Ile Leu Phe Ala Thr Leu Ser Cys Leu His Ile 
            100                 105                 110         


Trp Ile Leu Met Pro Phe Val Lys Thr Cys Leu Met Val Leu Pro Ser 
        115                 120                 125             


Val Gln Thr Ile Trp Lys Ser Val Thr Asp Val Ile Ile Ala Pro Leu 
    130                 135                 140                 


Cys Thr Ser Val Gly Arg Cys Phe Ser Ser Val Ser Leu Gln Leu Ser 
145                 150                 155                 160 


Gln Asp 
        


<210>  43
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  43
actcgccacc tcctcttcca cccctgccag gcccagcagc caccacagcg cctgcttcct     60

cggccctgaa atcatgcccc taggtctcct gtggctgggc ctagccctgt tgggggctct    120

gcatgcccag gcccaggact ccacctcaga cctgatccca gccccacctc tgagcaaggt    180

ccctctgcag cagaacttcc aggacaacca attccagggg aagtggtatg tggtaggcct    240

ggcagggaat gcaattctca gagaagacaa agacccgcaa aagatgtatg ccaccatcta    300

tgagctgaaa gaagacaaga gctacaatgt cacctccgtc ctgtttagga aaaagaagtg    360

tgactactgg atcaggactt ttgttccagg ttgccagccc ggcgagttca cgctgggcaa    420

cattaagagt taccctggat taacgagtta cctcgtccga gtggtgagca ccaactacaa    480

ccagcatgct atggtgttct tcaagaaagt ttctcaaaac agggagtact tcaagatcac    540

cctctacggg agaaccaagg agctgacttc ggaactaaag gagaacttca tccgcttctc    600

caaatctctg ggcctccctg aaaaccacat cgtcttccct gtcccaatcg accagtgtat    660

cgacggctga gtgcacaggt gccgccagct gccgcaccag cccgaacacc attgagggag    720

ctgggagacc ctccccacag tgccacccat gcagctgctc cccaggccac cccgctgatg    780

gagccccacc ttgtctgcta aataaacatg tgccctcagg ccaaaaaaaa aaaaaaaaaa    840


<210>  44
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
            20                  25                  30          


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
        35                  40                  45              


Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu 
    50                  55                  60                  


Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu 
65                  70                  75                  80  


Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys 
                85                  90                  95      


Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe 
            100                 105                 110         


Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val 
        115                 120                 125             


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
    130                 135                 140                 


Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg 
145                 150                 155                 160 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
                165                 170                 175     


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
            180                 185                 190         


Asp Gln Cys Ile Asp Gly 
        195             


<210>  45
<211>  813
<212>  DNA
<213>  Homo sapiens

<400>  45
acccgcgcct gaccgcggca gctcccacca tggcggagac caagctccag ctgtttgtca     60

aggcgagtga ggacggggag agcgtgggtc actgcccctc ctgccagcgg ctcttcatgg    120

tcctgctcct caagggcgta cctttcaccc tcaccacggt ggacacgcgc aggtccccgg    180

acgtgctgaa ggacttcgcc cccggctcgc agctgcccat cctgctctat gacagcgacg    240

ccaagacaga cacgctgcag atcgaggact ttctggagga gacgctgggg ccgcccgact    300

tccccagcct ggcgcctcgt tacagggagt ccaacaccgc cggcaacgac gttttccaca    360

agttctccgc gttcatcaag aacccggtgc ccgcgcagga cgaagccctg taccagcagc    420

tgctgcgcgc cctcgccagg ctggacagct acctgcgcgc gcccctggag cacgagctgg    480

cgggggagcc gcagctgcgc gagtcccgcc gccgcttcct ggacggcgac aggctcacgc    540

tggccgactg cagcctcctg cccaagctgc acatcgtcga cacggtgtgc gcgcacttcc    600

gccaggcgcc catccccgcg gagctgcgcg gcgtacgccg ctacctggac agcgcgatgc    660

aggagaaaga gttcaaatac acgtgtccgc acagcgccga gatcctggcg gcctaccggc    720

ccgccgtgca cccccgctag cgccccaccc cgcgtctgtc gcccaataaa ggcatctttg    780

tcgggagtga gggtgtcctg acatctgaag ggc                                 813


<210>  46
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Glu Thr Lys Leu Gln Leu Phe Val Lys Ala Ser Glu Asp Gly 
1               5                   10                  15      


Glu Ser Val Gly His Cys Pro Ser Cys Gln Arg Leu Phe Met Val Leu 
            20                  25                  30          


Leu Leu Lys Gly Val Pro Phe Thr Leu Thr Thr Val Asp Thr Arg Arg 
        35                  40                  45              


Ser Pro Asp Val Leu Lys Asp Phe Ala Pro Gly Ser Gln Leu Pro Ile 
    50                  55                  60                  


Leu Leu Tyr Asp Ser Asp Ala Lys Thr Asp Thr Leu Gln Ile Glu Asp 
65                  70                  75                  80  


Phe Leu Glu Glu Thr Leu Gly Pro Pro Asp Phe Pro Ser Leu Ala Pro 
                85                  90                  95      


Arg Tyr Arg Glu Ser Asn Thr Ala Gly Asn Asp Val Phe His Lys Phe 
            100                 105                 110         


Ser Ala Phe Ile Lys Asn Pro Val Pro Ala Gln Asp Glu Ala Leu Tyr 
        115                 120                 125             


Gln Gln Leu Leu Arg Ala Leu Ala Arg Leu Asp Ser Tyr Leu Arg Ala 
    130                 135                 140                 


Pro Leu Glu His Glu Leu Ala Gly Glu Pro Gln Leu Arg Glu Ser Arg 
145                 150                 155                 160 


Arg Arg Phe Leu Asp Gly Asp Arg Leu Thr Leu Ala Asp Cys Ser Leu 
                165                 170                 175     


Leu Pro Lys Leu His Ile Val Asp Thr Val Cys Ala His Phe Arg Gln 
            180                 185                 190         


Ala Pro Ile Pro Ala Glu Leu Arg Gly Val Arg Arg Tyr Leu Asp Ser 
        195                 200                 205             


Ala Met Gln Glu Lys Glu Phe Lys Tyr Thr Cys Pro His Ser Ala Glu 
    210                 215                 220                 


Ile Leu Ala Ala Tyr Arg Pro Ala Val His Pro Arg 
225                 230                 235     


<210>  47
<211>  1695
<212>  DNA
<213>  Homo sapiens

<400>  47
caagcaggat acgtttttct gttgggcatt gactagattg tttgcaaaag tttcgcatca     60

aaaacaaaca acaacaacaa aaaaccaaac aactctcctt gatctatact ttgagaattg    120

ttgatttctt tttttttatt ctgactttta aaaacaactt ttttttccac ttttttaaaa    180

aatgcactac tgtgtgctga gcgcttttct gatcctgcat ctggtcacgg tcgcgctcag    240

cctgtctacc tgcagcacac tcgatatgga ccagttcatg cgcaagagga tcgaggcgat    300

ccgcgggcag atcctgagca agctgaagct caccagtccc ccagaagact atcctgagcc    360

cgaggaagtc cccccggagg tgatttccat ctacaacagc accagggact tgctccagga    420

gaaggcgagc cggagggcgg ccgcctgcga gcgcgagagg agcgacgaag agtactacgc    480

caaggaggtt tacaaaatag acatgccgcc cttcttcccc tccgaaaatg ccatcccgcc    540

cactttctac agaccctact tcagaattgt tcgatttgac gtctcagcaa tggagaagaa    600

tgcttccaat ttggtgaaag cagagttcag agtctttcgt ttgcagaacc caaaagccag    660

agtgcctgaa caacggattg agctatatca gattctcaag tccaaagatt taacatctcc    720

aacccagcgc tacatcgaca gcaaagttgt gaaaacaaga gcagaaggcg aatggctctc    780

cttcgatgta actgatgctg ttcatgaatg gcttcaccat aaagacagga acctgggatt    840

taaaataagc ttacactgtc cctgctgcac ttttgtacca tctaataatt acatcatccc    900

aaataaaagt gaagaactag aagcaagatt tgcaggtatt gatggcacct ccacatatac    960

cagtggtgat cagaaaacta taaagtccac taggaaaaaa aacagtggga agaccccaca   1020

tctcctgcta atgttattgc cctcctacag acttgagtca caacagacca accggcggaa   1080

gaagcgtgct ttggatgcgg cctattgctt tagaaatgtg caggataatt gctgcctacg   1140

tccactttac attgatttca agagggatct agggtggaaa tggatacacg aacccaaagg   1200

gtacaatgcc aacttctgtg ctggagcatg cccgtattta tggagttcag acactcagca   1260

cagcagggtc ctgagcttat ataataccat aaatccagaa gcatctgctt ctccttgctg   1320

cgtgtcccaa gatttagaac ctctaaccat tctctactac attggcaaaa cacccaagat   1380

tgaacagctt tctaatatga ttgtaaagtc ttgcaaatgc agctaaaatt cttggaaaag   1440

tggcaagacc aaaatgacaa tgatgatgat aatgatgatg acgacgacaa cgatgatgct   1500

tgtaacaaga aaacataaga gagccttggt tcatcagtgt taaaaaattt ttgaaaaggc   1560

ggtactagtt cagacacttt ggaagtttgt gttctgtttg ttaaaactgg catctgacac   1620

aaaaaaagtt gaaggcctta ttctacattt cacctacttt gtaagtgaga gagacaagaa   1680

gcaaattttt ttaaa                                                    1695


<210>  48
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  48

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 
        355                 360                 365             


Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                 375                 380                 


Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile 
385                 390                 395                 400 


Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410                 


<210>  49
<211>  2070
<212>  DNA
<213>  Homo sapiens

<400>  49
caggagatgc ccaaagccag gcagagcccg ggggcgaggg gacggcaggc aggtgtggcg     60

ctgccctggg cgggcttgca cccccacacc caagtgagcg gcctgctcac tcctcagctg    120

caggagccag acgtgtggag tcccagcaga ggccaacctg tgtctcttca tctccctggg    180

aaaggtgccc ccgaggtgaa agagatggcc tggtggaaat cctggattga acaggagggt    240

gtcacagtga agagcagctc ccacttcaac ccagaccctg atgcagagac cctctacaaa    300

gccatgaagg ggatcgggac caacgagcag gctatcatcg atgtgctcac caagagaagc    360

aacacgcagc ggcagcagat cgccaagtcc ttcaaggctc agttcggcaa ggacctcact    420

gagaccttga agtctgagct cagtggcaag tttgagaggc tcattgtggc ccttatgtac    480

ccgccataca gatacgaagc caaggagctg catgacgcca tgaagggctt aggaaccaag    540

gagggtgtca tcattgagat cctggcctct cggaccaaga accagctgcg ggagataatg    600

aaggcgtatg aggaagacta tgggtccagc ctggaggagg acatccaagc agacacaagt    660

ggctacctgg agaggatcct ggtgtgcctc ctgcagggca gcagggatga tgtgagcagc    720

tttgtggacc caggactggc cctccaagac gcacaggatc tgtatgcggc aggcgagaag    780

attcgtggga ctgatgagat gaaattcatc accatcctgt gcacgcgcag tgccactcac    840

ctgctgagag tgtttgaaga gtatgagaaa attgccaaca agagcattga ggacagcatc    900

aagagtgaga cccatggctc actggaggag gccatgctca ctgtggtgaa atgcacccaa    960

aacctccaca gctactttgc agagagactc tactatgcca tgaagggagc agggacgcgt   1020

gatgggaccc tgataagaaa catcgtttca aggagcgaga ttgacttaaa tcttatcaaa   1080

tgtcacttca agaagatgta cggcaagacc ctcagcagca tgatcatgga agacaccagc   1140

ggtgactaca agaacgccct gctgagcctg gtgggcagcg acccctgagg cacagaagaa   1200

caagagcaaa gaccatgaag ccagagtctc caggactcct cactcaacct cggccatgga   1260

cgcaggttgg gtgtgagggg ggtcccagcc tttcggtctt ctatttccct atttccagtg   1320

ctttccagcc gggtttctga cccagagggt ggaaccggcc tggactcctc ttcccaactt   1380

cctccaggtc atttcccagt gtgagcacaa tgccaacctt agtgtttctc cagccagaca   1440

gatgcctcag catgaagggc ttggggactt gtggatcatt ccttcctccc tgcaggagct   1500

tcccaagctg gtcacagagt ctcctgggca caggttatac agaccccagc cccattccca   1560

tctactgaaa cagggtctcc acaagagggg ccagggaata tgggttttta acaagcgtct   1620

tacaaaacac ttctctatca tgcagccgga gagctggctg ggagcccttt tgttttagaa   1680

cacacatcct tcagcagctg agaaacgaac acgaatccat cccaaccgag atgccattaa   1740

cattcatcta aaaatgttag gctctaaatg gacgaaaaat tctctcgcca tcttaataac   1800

aaaataaact acaaattcct gacccaagga cactgtgtta taagaggcgt gggctcccct   1860

ggtggctgac caggtcagct gccctggcct tgcacccctc tgcatgcagc acagaagggt   1920

gtgaccatgc cctcagcacc actcttgtcc ccactgaacg gcaactgaga ctgggtacct   1980

ggagattctg aagtgccttt gctgtggttt tcaaaataat aaagatttgt attcaactca   2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                    2070


<210>  50
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Trp Trp Lys Ser Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Gly Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro 
                325         


<210>  51
<211>  1690
<212>  DNA
<213>  Homo sapiens

<400>  51
gtaactgaaa atccacaaga cagaatagcc agatctcaga ggagcctggc taagcaaaac     60

cctgcagaac ggctgcctaa tttacagcaa ccatgagtac aaatggtgat gatcatcagg    120

tcaaggatag tctggagcaa ttgagatgtc actttacatg ggagttatcc attgatgacg    180

atgaaatgcc tgatttagaa aacagagtct tggatcagat tgaattccta gacaccaaat    240

acagtgtggg aatacacaac ctactagcct atgtgaaaca cctgaaaggc cagaatgagg    300

aagccctgaa gagcttaaaa gaagctgaaa acttaatgca ggaagaacat gacaaccaag    360

caaatgtgag gagtctggtg acctggggca actttgcctg gatgtattac cacatgggca    420

gactggcaga agcccagact tacctggaca aggtggagaa catttgcaag aagctttcaa    480

atcccttccg ctatagaatg gagtgtccag aaatagactg tgaggaagga tgggccttgc    540

tgaagtgtgg aggaaagaat tatgaacggg ccaaggcctg ctttgaaaag gtgcttgaag    600

tggaccctga aaaccctgaa tccagcgctg ggtatgcgat ctctgcctat cgcctggatg    660

gctttaaatt agccacaaaa aatcacaagc cattttcttt gcttccccta aggcaggctg    720

tccgcttaaa tccagacaat ggatatatta aggttctcct tgccctgaag cttcaggatg    780

aaggacagga agctgaagga gaaaagtaca ttgaagaagc tctagccaac atgtcctcac    840

agacctatgt ctttcgatat gcagccaagt tttaccgaag aaaaggctct gtggataaag    900

ctcttgagtt attaaaaaag gccttgcagg aaacacccac ttctgtctta ctgcatcacc    960

agatagggct ttgctacaag gcacaaatga tccaaatcaa ggaggctaca aaagggcagc   1020

ctagagggca gaacagagaa aagctagaca aaatgataag atcagccata tttcattttg   1080

aatctgcagt ggaaaaaaag cccacatttg aggtggctca tctagacctg gcaagaatgt   1140

atatagaagc aggcaatcac agaaaagctg aagagaattt tcaaaaattg ttatgcatga   1200

aaccagtggt agaagaaaca atgcaagaca tacatttcca ctatggtcgg tttcaggaat   1260

ttcaaaagaa atctgacgtc aatgcaatta tccattattt aaaagctata aaaatagaac   1320

aggcatcatt aacaagggat aaaagtatca attctttgaa gaaattggtt ttaaggaaac   1380

ttcggagaaa ggcattagat ctggaaagct tgagcctcct tgggttcgtc tacaaattgg   1440

aaggaaatat gaatgaagcc ctggagtact atgagcgggc cctgagactg gctgctgact   1500

ttgagaactc tgtgagacaa ggtccttagg cacccagata tcagccactt tcacatttca   1560

tttcatttta tgctaacatt tactaatcat cttttctgct tactgttttc agaaacatta   1620

taattcactg taatgatgta attcttgaat aataaatctg acaaaaaaaa aaaaaaaaaa   1680

aaaaaaaaaa                                                          1690


<210>  52
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ser Thr Asn Gly Asp Asp His Gln Val Lys Asp Ser Leu Glu Gln 
1               5                   10                  15      


Leu Arg Cys His Phe Thr Trp Glu Leu Ser Ile Asp Asp Asp Glu Met 
            20                  25                  30          


Pro Asp Leu Glu Asn Arg Val Leu Asp Gln Ile Glu Phe Leu Asp Thr 
        35                  40                  45              


Lys Tyr Ser Val Gly Ile His Asn Leu Leu Ala Tyr Val Lys His Leu 
    50                  55                  60                  


Lys Gly Gln Asn Glu Glu Ala Leu Lys Ser Leu Lys Glu Ala Glu Asn 
65                  70                  75                  80  


Leu Met Gln Glu Glu His Asp Asn Gln Ala Asn Val Arg Ser Leu Val 
                85                  90                  95      


Thr Trp Gly Asn Phe Ala Trp Met Tyr Tyr His Met Gly Arg Leu Ala 
            100                 105                 110         


Glu Ala Gln Thr Tyr Leu Asp Lys Val Glu Asn Ile Cys Lys Lys Leu 
        115                 120                 125             


Ser Asn Pro Phe Arg Tyr Arg Met Glu Cys Pro Glu Ile Asp Cys Glu 
    130                 135                 140                 


Glu Gly Trp Ala Leu Leu Lys Cys Gly Gly Lys Asn Tyr Glu Arg Ala 
145                 150                 155                 160 


Lys Ala Cys Phe Glu Lys Val Leu Glu Val Asp Pro Glu Asn Pro Glu 
                165                 170                 175     


Ser Ser Ala Gly Tyr Ala Ile Ser Ala Tyr Arg Leu Asp Gly Phe Lys 
            180                 185                 190         


Leu Ala Thr Lys Asn His Lys Pro Phe Ser Leu Leu Pro Leu Arg Gln 
        195                 200                 205             


Ala Val Arg Leu Asn Pro Asp Asn Gly Tyr Ile Lys Val Leu Leu Ala 
    210                 215                 220                 


Leu Lys Leu Gln Asp Glu Gly Gln Glu Ala Glu Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Glu Glu Ala Leu Ala Asn Met Ser Ser Gln Thr Tyr Val Phe Arg Tyr 
                245                 250                 255     


Ala Ala Lys Phe Tyr Arg Arg Lys Gly Ser Val Asp Lys Ala Leu Glu 
            260                 265                 270         


Leu Leu Lys Lys Ala Leu Gln Glu Thr Pro Thr Ser Val Leu Leu His 
        275                 280                 285             


His Gln Ile Gly Leu Cys Tyr Lys Ala Gln Met Ile Gln Ile Lys Glu 
    290                 295                 300                 


Ala Thr Lys Gly Gln Pro Arg Gly Gln Asn Arg Glu Lys Leu Asp Lys 
305                 310                 315                 320 


Met Ile Arg Ser Ala Ile Phe His Phe Glu Ser Ala Val Glu Lys Lys 
                325                 330                 335     


Pro Thr Phe Glu Val Ala His Leu Asp Leu Ala Arg Met Tyr Ile Glu 
            340                 345                 350         


Ala Gly Asn His Arg Lys Ala Glu Glu Asn Phe Gln Lys Leu Leu Cys 
        355                 360                 365             


Met Lys Pro Val Val Glu Glu Thr Met Gln Asp Ile His Phe His Tyr 
    370                 375                 380                 


Gly Arg Phe Gln Glu Phe Gln Lys Lys Ser Asp Val Asn Ala Ile Ile 
385                 390                 395                 400 


His Tyr Leu Lys Ala Ile Lys Ile Glu Gln Ala Ser Leu Thr Arg Asp 
                405                 410                 415     


Lys Ser Ile Asn Ser Leu Lys Lys Leu Val Leu Arg Lys Leu Arg Arg 
            420                 425                 430         


Lys Ala Leu Asp Leu Glu Ser Leu Ser Leu Leu Gly Phe Val Tyr Lys 
        435                 440                 445             


Leu Glu Gly Asn Met Asn Glu Ala Leu Glu Tyr Tyr Glu Arg Ala Leu 
    450                 455                 460                 


Arg Leu Ala Ala Asp Phe Glu Asn Ser Val Arg Gln Gly Pro 
465                 470                 475             


<210>  53
<211>  1881
<212>  DNA
<213>  Homo sapiens

<400>  53
cctgcatctt tttggaagga ttctttttat aaatcagaaa gtgttcgagg ttcaaaggtt     60

tgcctcggag cgtgtgaaca ttcctccgct cggttttcaa ctcgcctcca acctgcgccg    120

cccggccagc atgtctcccc gcccgtgaag cggggctgcc gcctccctgc cgctccggct    180

gccactaacg acccgccctc gccgccacct ggccctcctg atcgacgaca cacgcacttg    240

aaacttgttc tcagggtgtg tggaatcaac tttccggaag caaccagccc accagaggag    300

gtcccgagcg cgagcggaga cgatgcagcg gagactggtt cagcagtgga gcgtcgcggt    360

gttcctgctg agctacgcgg tgccctcctg cgggcgctcg gtggagggtc tcagccgccg    420

cctcaaaaga gctgtgtctg aacatcagct cctccatgac aaggggaagt ccatccaaga    480

tttacggcga cgattcttcc ttcaccatct gatcgcagaa atccacacag ctgaaatcag    540

agctacctcg gaggtgtccc ctaactccaa gccctctccc aacacaaaga accaccccgt    600

ccgatttggg tctgatgatg agggcagata cctaactcag gaaactaaca aggtggagac    660

gtacaaagag cagccgctca agacacctgg gaagaaaaag aaaggcaagc ccgggaaacg    720

caaggagcag gaaaagaaaa aacggcgaac tcgctctgcc tggttagact ctggagtgac    780

tgggagtggg ctagaagggg accacctgtc tgacacctcc acaacgtcgc tggagctcga    840

ttcacggtaa caggcttctc tggcccgtag cctcagcggg gtgctctcag ctgggttttg    900

gagcctccct tctgccttgg cttggacaaa cctagaattt tctcccttta tgtatctcta    960

tcgattgtgt agcaattgac agagaataac tcagaatatt gtctgcctta aagcagtacc   1020

cccctaccac acacacccct gtcctccagc accatagaga ggcgctagag cccattcctc   1080

tttctccacc gtcacccaac atcaatcctt taccactcta ccaaataatt tcatattcaa   1140

gcttcagaag ctagtgacca tcttcataat ttgctggaga agtgtgtttc ttccccttac   1200

tctcacacct gggcaaactt tcttcagtgt ttttcatttc ttacgttctt tcacttcaag   1260

ggagaatata gaagcatttg atattatcta caaacactgc agaacagcat catgtcataa   1320

acgattctga gccattcaca ctttttattt aattaaatgt atttaattaa atctcaaatt   1380

tattttaatg taaagaactt aaattatgtt ttaaacacat gccttaaatt tgtttaatta   1440

aatttaactc tggtttctac cagctcatac aaaataaatg gtttctgaaa atgtttaagt   1500

attaacttac aaggatatag gtttttctca tgtatctttt tgttcattgg caagatgaaa   1560

taatttttct agggtaatgc cgtaggaaaa ataaaacttc acatttatgt ggcttgttta   1620

tccttagctc acagattgag gtaataatga cactcctaga ctttgggatc aaataactta   1680

gggccaagtc ttgggtctga atttatttaa gttcacaacc tagggcaagt tactctgcct   1740

ttctaagact cacttacatc ttctgtgaaa tataattgta ccaacctcat agagtttggt   1800

gtcaactaaa tgagattata tgtggactaa atatctgtca tatagtaaac actcaataaa   1860

ttgcaacata ttaaaaaaaa a                                             1881


<210>  54
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Gln Arg Arg Leu Val Gln Gln Trp Ser Val Ala Val Phe Leu Leu 
1               5                   10                  15      


Ser Tyr Ala Val Pro Ser Cys Gly Arg Ser Val Glu Gly Leu Ser Arg 
            20                  25                  30          


Arg Leu Lys Arg Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly 
        35                  40                  45              


Lys Ser Ile Gln Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile 
    50                  55                  60                  


Ala Glu Ile His Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro 
65                  70                  75                  80  


Asn Ser Lys Pro Ser Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly 
                85                  90                  95      


Ser Asp Asp Glu Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu 
            100                 105                 110         


Thr Tyr Lys Glu Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly 
        115                 120                 125             


Lys Pro Gly Lys Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg 
    130                 135                 140                 


Ser Ala Trp Leu Asp Ser Gly Val Thr Gly Ser Gly Leu Glu Gly Asp 
145                 150                 155                 160 


His Leu Ser Asp Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser Arg 
                165                 170                 175 


<210>  55
<211>  4713
<212>  DNA
<213>  Homo sapiens

<400>  55
ggaaatctgg cattttttaa agtttgcgcc ccacaaagag gaaatattcc aaaggtactc     60

aggatgtaaa aggggagatc ttcacagatg cctccgtgga tggcatggca atccatccat    120

caatgagaag accatgattt cttttaattt tctgtgtgtt tccacattcc ccagtgagaa    180

ttcttccacc tttttttgtg ccatgggaaa aacctgaagg gcaggcagag ctgctcccga    240

acttgtgacc ttctctgagg ttgcagcggc tcttgtagaa catgactctg ggacatcact    300

tccttttgtt ttctttcgga gctgaaccaa agaatgtgca ccctctttct ctagtgctgt    360

ggtgtctgct tatttttgta tttgtgcttt ccatccatct tctgtgatca caaggcattc    420

ttaaggtttt ctagcacgac ttgcggacat ccagactcgt ggggggccca cccatggctc    480

ggtaagccag cagcccaggg cactggcact accatgaggc actgcattaa ttgctgcata    540

cagctgttac ccgacggcgc acacaagcag caggtcaact gccaaggggg cccccatcac    600

ggtcaccagg cgtgccccac gtgcaaagga gaaaacaaaa ttctgtttcg tgtggacagt    660

aagcagatga acttgcttgc tgttctcgaa gtgaggactg aagggaacga aaactggggt    720

gggtttttgc gcttcaaaaa ggggaagcga tgtagcctcg tttttggact gataataatg    780

accttggtaa tggcttctta catcctttct ggggcccacc aagagcttct gatctcatca    840

cctttccatt acggaggctt ccccagcaac cccagcttga tggacagcga aaacccaagt    900

gacacaaagg agcatcacca ccaatcctct gtaaataata tttcatacat gaaggactat    960

ccaagcatta aattaattat caacagcatc acaactagga ttgagttcac gaccagacag   1020

ctcccagact tagaagacct taagaagcag gagttgcata tgttttcagt catccccaac   1080

aaattccttc caaacagtaa gagcccctgt tggtacgagg agttctcggg gcagaacacc   1140

accgacccct acctcaccaa ctcctacgtg ctctactcca agcgcttccg ctccaccttc   1200

gacgccctgc gcaaggcctt ctggggccac ctggcgcacg cgcacgggaa gcacttccgc   1260

ctgcgctgcc tgccgcactt ctacatcata gggcagccca agtgcgggac cacagacctc   1320

tatgaccgcc tgcggctgca ccctgaggtc aagttctccg ccatcaagga gccacactgg   1380

tggacccgga agcgctttgg aatcgtccgc ctaagagatg ggctgcgaga ccgctatccc   1440

gtggaagatt atctggacct ctttgacctg gccgcacacc agatccatca aggactgcag   1500

gccagctctg caaaggagca gagcaagatg aatacaatca ttatcgggga ggccagtgcc   1560

tccacgatgt gggataataa tgcctggacg ttcttctacg acaacagcac ggatggcgag   1620

ccaccgtttc tgacgcagga cttcatccac gcctttcagc caaatgccag actgattgtc   1680

atgctcaggg accctgtgga gaggttgtac tcagactatc tctactttgc aagttcgaat   1740

aaatccgcgg acgacttcca tgagaaagtg acagaagcac tgcagctgtt tgaaaattgc   1800

atgcttgatt attcactgcg cgcctgcgtc tacaacaaca ccctcaacaa cgccatgcct   1860

gtgaggctcc aggttgggct ctatgctgtg taccttctgg actggctcag cgtttttgac   1920

aagcaacagt ttctcattct tcgcctggaa gatcatgcat ccaacgtcaa gtacaccatg   1980

cacaaggtct tccagtttct gaacctaggg cccttaagtg agaagcagga ggctttgatg   2040

accaagagcc ccgcatccaa tgcacggcgt cccgaggacc ggaacctggg gcccatgtgg   2100

cccatcacac agaagattct gcgggatttc tacaggccct tcaacgctag gctggcgcag   2160

gtcctcgcgg atgaggcgtt tgcgtggaag acgacgtgag agctgaattg ttgctgcacg   2220

tgctgggccc gccaatgccg tcatcatcag gattttacaa atctctttgc ggggaactgt   2280

ttcactcatg gtatggaaaa ccccaggact ctgccactct aggcacacat gaattataac   2340

cattttggaa tttccttcgt gatgttcgag agctcagcaa tggacccctc acagagctcc   2400

tctatccgag gccattggag accccagttt ctcaagaatt cagctctgct ctgagcgtcc   2460

tggagcttgg ggatgcagcc agctggcctg cactgggtgt ggagagaaca cctagggaag   2520

gcagcctggc cctgcccgcc tccgccttct ggagagcctc tgggttctga gtcagcaagc   2580

cagaggtcat gccacaggcc tggctggaac ttacacttca cgttcccttt ttttccccct   2640

agagatgggg tctcgccgtg ttgcacagac tgtctgtatt caatggctat cttcacaggt   2700

gtgatcatac cacattcact tctgaaacac tcttgttgcg atcgctaacc tcactgggac   2760

agagaaccgc agtctttcga gaatggaggc tcttcatttt ttttttctcc tttactccaa   2820

actcagccct ccagtttctt cagatgtaaa ccctgttaac gtcactgttt ccaaaaggaa   2880

aaaaataagt cagtttttgg cagcaccttc atctttctga cctcctccta ttctgtcctt   2940

gtggacttat gtttaacata gaaaatgaat gcgtttaaaa caaaaccact ttctgcattt   3000

aaccagtcct ggctctctct ctgctgcctc ttcatacgtt ttctcaagaa cttcagttta   3060

taattggaag agaaattttt gctgttaatg ccagaatgag caacctcaag gaattgaaca   3120

cttcttggaa aatctaggta attcaagccc tcatcaggtt tacaagatca tcagagaaac   3180

agaggatttt aatttttagt tctggccggc tacaggctcc atttctctgc cttcccattg   3240

gaaatagttt atttccacat tctccactgc gtgtggtcaa agttcctcac ccagcaaggg   3300

actatagata ctcgtgtccc aattccaaaa cacaatgcac aagctgaact tgggctgaac   3360

gtggcgtgtt gagatttgga atgaggtttc taagagccgt gttcttcatg gaattttcca   3420

ggccacttgg cagcttggtt taccgatgga tgggctagag atcttgtcgt ttcttggaag   3480

tcacagggaa gattgaagag aacgcttgag catccttggc aacagcccag gtgggacctg   3540

gatgaagctt tgcactcaag tattgtcaag ggaagcttcc tgtgaaccaa agttctcagg   3600

ccaaggtctc gcccaccaaa gccagaaagt gcaagcaccc gtctacccag ctctaacttg   3660

tatgtgtgag acagaccagg cttcgggggt aggaggatct gcagttgttc agccgtcttt   3720

ctgctggtgt tgtctttctg ccatcagaga agggacacac agcccgttcg aaggtgtgca   3780

gagggctctg agcgccagga tggccagggc tgtttttgct actgaaggag cgtgtgtcct   3840

gaactcccac ttgcagggac agtccccacc ttctctatag ccggcactgg gagcagccgc   3900

cagcagggaa atctggcctg agcacaagga tgctttaggg agagatcact tcagtgtgtg   3960

tgtatattta tttgcagtac agtgcgcgcg tgtgtgtgtg tgtacgcgca cgtgtgggtg   4020

agtgcgtctt ctgagtgggt tctgttcagt tgctaatgag gctcctccgc tctggacaca   4080

acccttttat agattaattt ctctgccaat taacttgtca ttttcagtac atattttact   4140

attccacacc aaccataatt acaacaaggg atttttctta tgcactccta tgcatgtgaa   4200

taacatgtgg tgtaattctg cttcttacag aagtattact gaaggtatta tttccaatat   4260

tatttggttt attatgcgga tcttttttat atatgcagtc ccatcccttc tgtgccactc   4320

aatgccatcc agacatggtt tttccctcca ggggcctttc tctccagagg gcacttcggc   4380

tgcctctgct tcctctcatt cgaggcccgg ctcttgctga cagaataggt tccgttctgg   4440

gcggtggttc tcgagcctgc cattcaaaac caaagcaaat tggagcattt ctcacaacat   4500

ggtattgaag ttcctttttg ttctcaaaag ttgtgaccgt gttaaattgt actcccttag   4560

tcctgtaagg tatgttaagt gaatcgcagt tacgctgtac ttttattaat atttaacata   4620

attaaagatg gacccataag agtgacgcct gtggagcgcg tgctcttcct ctgcagccaa   4680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                4713


<210>  56
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Arg His Cys Ile Asn Cys Cys Ile Gln Leu Leu Pro Asp Gly Ala 
1               5                   10                  15      


His Lys Gln Gln Val Asn Cys Gln Gly Gly Pro His His Gly His Gln 
            20                  25                  30          


Ala Cys Pro Thr Cys Lys Gly Glu Asn Lys Ile Leu Phe Arg Val Asp 
        35                  40                  45              


Ser Lys Gln Met Asn Leu Leu Ala Val Leu Glu Val Arg Thr Glu Gly 
    50                  55                  60                  


Asn Glu Asn Trp Gly Gly Phe Leu Arg Phe Lys Lys Gly Lys Arg Cys 
65                  70                  75                  80  


Ser Leu Val Phe Gly Leu Ile Ile Met Thr Leu Val Met Ala Ser Tyr 
                85                  90                  95      


Ile Leu Ser Gly Ala His Gln Glu Leu Leu Ile Ser Ser Pro Phe His 
            100                 105                 110         


Tyr Gly Gly Phe Pro Ser Asn Pro Ser Leu Met Asp Ser Glu Asn Pro 
        115                 120                 125             


Ser Asp Thr Lys Glu His His His Gln Ser Ser Val Asn Asn Ile Ser 
    130                 135                 140                 


Tyr Met Lys Asp Tyr Pro Ser Ile Lys Leu Ile Ile Asn Ser Ile Thr 
145                 150                 155                 160 


Thr Arg Ile Glu Phe Thr Thr Arg Gln Leu Pro Asp Leu Glu Asp Leu 
                165                 170                 175     


Lys Lys Gln Glu Leu His Met Phe Ser Val Ile Pro Asn Lys Phe Leu 
            180                 185                 190         


Pro Asn Ser Lys Ser Pro Cys Trp Tyr Glu Glu Phe Ser Gly Gln Asn 
        195                 200                 205             


Thr Thr Asp Pro Tyr Leu Thr Asn Ser Tyr Val Leu Tyr Ser Lys Arg 
    210                 215                 220                 


Phe Arg Ser Thr Phe Asp Ala Leu Arg Lys Ala Phe Trp Gly His Leu 
225                 230                 235                 240 


Ala His Ala His Gly Lys His Phe Arg Leu Arg Cys Leu Pro His Phe 
                245                 250                 255     


Tyr Ile Ile Gly Gln Pro Lys Cys Gly Thr Thr Asp Leu Tyr Asp Arg 
            260                 265                 270         


Leu Arg Leu His Pro Glu Val Lys Phe Ser Ala Ile Lys Glu Pro His 
        275                 280                 285             


Trp Trp Thr Arg Lys Arg Phe Gly Ile Val Arg Leu Arg Asp Gly Leu 
    290                 295                 300                 


Arg Asp Arg Tyr Pro Val Glu Asp Tyr Leu Asp Leu Phe Asp Leu Ala 
305                 310                 315                 320 


Ala His Gln Ile His Gln Gly Leu Gln Ala Ser Ser Ala Lys Glu Gln 
                325                 330                 335     


Ser Lys Met Asn Thr Ile Ile Ile Gly Glu Ala Ser Ala Ser Thr Met 
            340                 345                 350         


Trp Asp Asn Asn Ala Trp Thr Phe Phe Tyr Asp Asn Ser Thr Asp Gly 
        355                 360                 365             


Glu Pro Pro Phe Leu Thr Gln Asp Phe Ile His Ala Phe Gln Pro Asn 
    370                 375                 380                 


Ala Arg Leu Ile Val Met Leu Arg Asp Pro Val Glu Arg Leu Tyr Ser 
385                 390                 395                 400 


Asp Tyr Leu Tyr Phe Ala Ser Ser Asn Lys Ser Ala Asp Asp Phe His 
                405                 410                 415     


Glu Lys Val Thr Glu Ala Leu Gln Leu Phe Glu Asn Cys Met Leu Asp 
            420                 425                 430         


Tyr Ser Leu Arg Ala Cys Val Tyr Asn Asn Thr Leu Asn Asn Ala Met 
        435                 440                 445             


Pro Val Arg Leu Gln Val Gly Leu Tyr Ala Val Tyr Leu Leu Asp Trp 
    450                 455                 460                 


Leu Ser Val Phe Asp Lys Gln Gln Phe Leu Ile Leu Arg Leu Glu Asp 
465                 470                 475                 480 


His Ala Ser Asn Val Lys Tyr Thr Met His Lys Val Phe Gln Phe Leu 
                485                 490                 495     


Asn Leu Gly Pro Leu Ser Glu Lys Gln Glu Ala Leu Met Thr Lys Ser 
            500                 505                 510         


Pro Ala Ser Asn Ala Arg Arg Pro Glu Asp Arg Asn Leu Gly Pro Met 
        515                 520                 525             


Trp Pro Ile Thr Gln Lys Ile Leu Arg Asp Phe Tyr Arg Pro Phe Asn 
    530                 535                 540                 


Ala Arg Leu Ala Gln Val Leu Ala Asp Glu Ala Phe Ala Trp Lys Thr 
545                 550                 555                 560 


Thr 
    


<210>  57
<211>  3445
<212>  DNA
<213>  Homo sapiens

<400>  57
gagcaaccgc agcttctagt atccagactc cagcgccgcc ccgggcgcgg accccaaccc     60

cgacccagag cttctccagc ggcggcgcag cgagcagggc tccccgcctt aacttcctcc    120

gcggggccca gccaccttcg ggagtccggg ttgcccacct gcaaactctc cgccttctgc    180

acctgccacc cctgagccag cgcgggcgcc cgagcgagtc atggccaacg cggggctgca    240

gctgttgggc ttcattctcg ccttcctggg atggatcggc gccatcgtca gcactgccct    300

gccccagtgg aggatttact cctatgccgg cgacaacatc gtgaccgccc aggccatgta    360

cgaggggctg tggatgtcct gcgtgtcgca gagcaccggg cagatccagt gcaaagtctt    420

tgactccttg ctgaatctga gcagcacatt gcaagcaacc cgtgccttga tggtggttgg    480

catcctcctg ggagtgatag caatctttgt ggccaccgtt ggcatgaagt gtatgaagtg    540

cttggaagac gatgaggtgc agaagatgag gatggctgtc attgggggtg cgatatttct    600

tcttgcaggt ctggctattt tagttgccac agcatggtat ggcaatagaa tcgttcaaga    660

attctatgac cctatgaccc cagtcaatgc caggtacgaa tttggtcagg ctctcttcac    720

tggctgggct gctgcttctc tctgccttct gggaggtgcc ctactttgct gttcctgtcc    780

ccgaaaaaca acctcttacc caacaccaag gccctatcca aaacctgcac cttccagcgg    840

gaaagactac gtgtgacaca gaggcaaaag gagaaaatca tgttgaaaca aaccgaaaat    900

ggacattgag atactatcat taacattagg accttagaat tttgggtatt gtaatctgaa    960

gtatggtatt acaaaacaaa caaacaaaca aaaaacccat gtgttaaaat actcagtgct   1020

aaacatggct taatcttatt ttatcttctt tcctcaatat aggagggaag atttttccat   1080

ttgtattact gcttcccatt gagtaatcat actcaattgg gggaaggggt gctccttaaa   1140

tatatataga tatgtatata tacatgtttt tctattaaaa atagacagta aaatactatt   1200

ctcattatgt tgatactagc atacttaaaa tatctctaaa ataggtaaat gtatttaatt   1260

ccatattgat gaagatgttt attggtatat tttctttttc gtctatatat acatatgtaa   1320

cagtcaaata tcatttactc ttcttcatta gctttgggtg cctttgccac aagacctagc   1380

ctaatttacc aaggatgaat tctttcaatt cttcatgcgt gcccttttca tatacttatt   1440

ttatttttta ccataatctt atagcacttg catcgttatt aagcccttat ttgttttgtg   1500

tttcattggt ctctatctcc tgaatctaac acatttcata gcctacattt tagtttctaa   1560

agccaagaag aatttattac aaatcagaac tttggaggca aatctttctg catgaccaaa   1620

gtgataaatt cctgttgacc ttcccacaca atccctgtac tctgacccat agcactcttg   1680

tttgctttga aaatatttgt ccaattgagt agctgcatgc tgttccccca ggtgttgtaa   1740

cacaacttta ttgattgaat ttttaagcta cttattcata gttttatatc cccctaaact   1800

acctttttgt tccccattcc ttaattgtat tgttttccca agtgtaatta tcatgcgttt   1860

tatatcttcc taataaggtg tggtctgttt gtctgaacaa agtgctagac tttctggagt   1920

gataatctgg tgacaaatat tctctctgta gctgtaagca agtcacttaa tctttctacc   1980

tcttttttct atctgccaaa ttgagataat gatacttaac cagttagaag aggtagtgtg   2040

aatattaatt agtttatatt actctcattc tttgaacatg aactatgcct atgtagtgtc   2100

tttatttgct cagctggctg agacactgaa gaagtcactg aacaaaacct acacacgtac   2160

cttcatgtga ttcactgcct tcctctctct accagtctat ttccactgaa caaaacctac   2220

acacatacct tcatgtggtt cagtgccttc ctctctctac cagtctattt ccactgaaca   2280

aaacctacgc acataccttc atgtggctca gtgccttcct ctctctacca gtctatttcc   2340

attctttcag ctgtgtctga catgtttgtg ctctgttcca ttttaacaac tgctcttact   2400

tttccagtct gtacagaatg ctatttcact tgagcaagat gatgtaatgg aaagggtgtt   2460

ggcattggtg tctggagacc tggatttgag tcttggtgct atcaatcacc gtctgtgttt   2520

gagcaaggca tttggctgct gtaagcttat tgcttcatct gtaagcggtg gtttgtaatt   2580

cctgatcttc ccacctcaca gtgatgttgt ggggatccag tgagatagaa tacatgtaag   2640

tgtggttttg taatttaaaa agtgctatac taagggaaag aattgaggaa ttaactgcat   2700

acgttttggt gttgcttttc aaatgtttga aaacaaaaaa aatgttaaga aatgggtttc   2760

ttgccttaac cagtctctca agtgatgaga cagtgaagta aaattgagtg cactaaacaa   2820

ataagattct gaggaagtct tatcttctgc agtgagtatg gcccgatgct ttctgtggct   2880

aaacagatgt aatgggaaga aataaaagcc tacgtgttgg taaatccaac agcaagggag   2940

atttttgaat cataataact cataaggtgc tatctgttca gtgatgccct cagagctctt   3000

gctgttagct ggcagctgac gctgctagga tagttagttt ggaaatggta cttcataata   3060

aactacacaa ggaaagtcag ccactgtgtc ttatgaggaa ttggacctaa taaattttag   3120

tgtgccttcc aaacctgaga atatatgctt ttggaagtta aaatttaaat ggcttttgcc   3180

acatacatag atcttcatga tgtgtgagtg taattccatg tggatatcag ttaccaaaca   3240

ttacaaaaaa attttatggc ccaaaatgac caacgaaatt gttacaatag aatttatcca   3300

attttgatct ttttatattc ttctaccaca cctggaaaca gaccaataga cattttgggg   3360

ttttataata ggaatttgta taaagcatta ctctttttca ataaattgtt ttttaattta   3420

aaaaaaggaa aaaaaaaaaa aaaaa                                         3445


<210>  58
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Asn Ala Gly Leu Gln Leu Leu Gly Phe Ile Leu Ala Phe Leu 
1               5                   10                  15      


Gly Trp Ile Gly Ala Ile Val Ser Thr Ala Leu Pro Gln Trp Arg Ile 
            20                  25                  30          


Tyr Ser Tyr Ala Gly Asp Asn Ile Val Thr Ala Gln Ala Met Tyr Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Ser Gln Ser Thr Gly Gln Ile Gln Cys 
    50                  55                  60                  


Lys Val Phe Asp Ser Leu Leu Asn Leu Ser Ser Thr Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Gly Ile Leu Leu Gly Val Ile Ala Ile Phe 
                85                  90                  95      


Val Ala Thr Val Gly Met Lys Cys Met Lys Cys Leu Glu Asp Asp Glu 
            100                 105                 110         


Val Gln Lys Met Arg Met Ala Val Ile Gly Gly Ala Ile Phe Leu Leu 
        115                 120                 125             


Ala Gly Leu Ala Ile Leu Val Ala Thr Ala Trp Tyr Gly Asn Arg Ile 
    130                 135                 140                 


Val Gln Glu Phe Tyr Asp Pro Met Thr Pro Val Asn Ala Arg Tyr Glu 
145                 150                 155                 160 


Phe Gly Gln Ala Leu Phe Thr Gly Trp Ala Ala Ala Ser Leu Cys Leu 
                165                 170                 175     


Leu Gly Gly Ala Leu Leu Cys Cys Ser Cys Pro Arg Lys Thr Thr Ser 
            180                 185                 190         


Tyr Pro Thr Pro Arg Pro Tyr Pro Lys Pro Ala Pro Ser Ser Gly Lys 
        195                 200                 205             


Asp Tyr Val 
    210     


<210>  59
<211>  656
<212>  DNA
<213>  Homo sapiens

<400>  59
gggaacacat ccaagcttaa gacggtgagg tcagcttcac attctcagga actctccttc     60

tttgggtctg gctgaagttg aggatctctt actctctagg ccacggaatt aacccgagca    120

ggcatggagg cctctgctct cacctcatca gcagtgacca gtgtggccaa agtggtcagg    180

gtggcctctg gctctgccgt agttttgccc ctggccagga ttgctacagt tgtgattgga    240

ggagttgtgg ctgtgcccat ggtgctcagt gccatgggct tcactgcggc gggaatcgcc    300

tcgtcctcca tagcagccaa gatgatgtcc gcggcggcca ttgccaatgg gggtggagtt    360

gcctcgggca gccttgtggc tactctgcag tcactgggag caactggact ctccggattg    420

accaagttca tcctgggctc cattgggtct gccattgcgg ctgtcattgc gaggttctac    480

tagctccctg cccctcgccc tgcagagaag agaaccatgc caggggagaa ggcacccagc    540

catcctgacc cagcgaggag ccaactatcc caaatatacc tggggtgaaa tataccaaat    600

tctgcatctc cagaggaaaa taagaaataa agatgaattg ttgcaactct tcaaaa        656


<210>  60
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
1               5                   10                  15      


Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
            20                  25                  30          


Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Val Pro Met Val Leu 
        35                  40                  45              


Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser Ser Ser Ile Ala 
    50                  55                  60                  


Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly Gly Val Ala 
65                  70                  75                  80  


Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala Thr Gly Leu 
                85                  90                  95      


Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser Ala Ile Ala 
            100                 105                 110         


Ala Val Ile Ala Arg Phe Tyr 
        115                 


<210>  61
<211>  1219
<212>  DNA
<213>  Homo sapiens

<400>  61
gaatagtcta ccccccttgc actctacctg acacagctgc agcctgcaat tcactcgcac     60

tgcctgggat tgcactggat ccgtgtgctc agaacaaggt gaacgcccag ctgcagccat    120

gaagatctgt agcctcaccc tgctctcctt cctcctactg gctgctcagg tgctcctggt    180

ggaggggaaa aaaaaagtga agaatggact tcacagcaaa gtggtctcag aacaaaagga    240

cactctgggc aacacccaga ttaagcagaa aagcaggccc gggaacaaag gcaagtttgt    300

caccaaagac caagccaact gcagatgggc tgctactgag caggaggagg gcatctctct    360

caaggttgag tgcactcaat tggaccatga attttcctgt gtctttgctg gcaatccaac    420

ctcatgccta aagctcaagg atgagagagt ctattggaaa caagttgccc ggaatctgcg    480

ctcacagaaa gacatctgta gatattccaa gacagctgtg aaaaccagag tgtgcagaaa    540

ggattttcca gaatccagtc ttaagctagt cagctccact ctatttggga acacaaagcc    600

caggaaggag aaaacagaga tgtcccccag ggagcacatc aaaggcaaag agaccacccc    660

ctctagccta gcagtgaccc agaccatggc caccaaagct cccgagtgtg tggaggaccc    720

agatatggca aaccagagga agactgccct ggagttctgt ggagagactt ggagctctct    780

ctgcacattc ttcctcagca tagtgcagga cacgtcatgc taatgaggtc aaaagagaac    840

gggttccctt aagagatgtc atgtcgtaag tccctctgta tactttaaag ctctctacag    900

tccccccaaa atatgaactt ttgtgcttag tgagtgcaac gaaatattta aacaagtttt    960

gtattttttg cttttgtgtt ttggaatttg ccttattttt cttggatgcg atgttcagag   1020

gctgtttcct gcagcatgta tttccatggc ccacacagct atgtgtttga gcagcgaaga   1080

gtctttgagc tgaatgagcc agagtgataa tttcagtgca acgaactttc tgctgaatta   1140

atggtaataa aactctgggt gtttttcaga aatacattca aaaaaaaaaa aaaaaaaaaa   1200

aaaaaaaaaa aaaaaaaaa                                                1219


<210>  62
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Lys Ile Cys Ser Leu Thr Leu Leu Ser Phe Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gln Val Leu Leu Val Glu Gly Lys Lys Lys Val Lys Asn Gly Leu His 
            20                  25                  30          


Ser Lys Val Val Ser Glu Gln Lys Asp Thr Leu Gly Asn Thr Gln Ile 
        35                  40                  45              


Lys Gln Lys Ser Arg Pro Gly Asn Lys Gly Lys Phe Val Thr Lys Asp 
    50                  55                  60                  


Gln Ala Asn Cys Arg Trp Ala Ala Thr Glu Gln Glu Glu Gly Ile Ser 
65                  70                  75                  80  


Leu Lys Val Glu Cys Thr Gln Leu Asp His Glu Phe Ser Cys Val Phe 
                85                  90                  95      


Ala Gly Asn Pro Thr Ser Cys Leu Lys Leu Lys Asp Glu Arg Val Tyr 
            100                 105                 110         


Trp Lys Gln Val Ala Arg Asn Leu Arg Ser Gln Lys Asp Ile Cys Arg 
        115                 120                 125             


Tyr Ser Lys Thr Ala Val Lys Thr Arg Val Cys Arg Lys Asp Phe Pro 
    130                 135                 140                 


Glu Ser Ser Leu Lys Leu Val Ser Ser Thr Leu Phe Gly Asn Thr Lys 
145                 150                 155                 160 


Pro Arg Lys Glu Lys Thr Glu Met Ser Pro Arg Glu His Ile Lys Gly 
                165                 170                 175     


Lys Glu Thr Thr Pro Ser Ser Leu Ala Val Thr Gln Thr Met Ala Thr 
            180                 185                 190         


Lys Ala Pro Glu Cys Val Glu Asp Pro Asp Met Ala Asn Gln Arg Lys 
        195                 200                 205             


Thr Ala Leu Glu Phe Cys Gly Glu Thr Trp Ser Ser Leu Cys Thr Phe 
    210                 215                 220                 


Phe Leu Ser Ile Val Gln Asp Thr Ser Cys 
225                 230                 


<210>  63
<211>  586
<212>  DNA
<213>  Homo sapiens

<400>  63
aaacactctg tgtggctcct cggctttgac agagtgcaag acgatgactt gcaaaatgtc     60

gcagctggaa cgcaacatag agaccatcat caacaccttc caccaatact ctgtgaagct    120

ggggcaccca gacaccctga accaggggga attcaaagag ctggtgcgaa aagatctgca    180

aaattttctc aagaaggaga ataagaatga aaaggtcata gaacacatca tggaggacct    240

ggacacaaat gcagacaagc agctgagctt cgaggagttc atcatgctga tggcgaggct    300

aacctgggcc tcccacgaga agatgcacga gggtgacgag ggccctggcc accaccataa    360

gccaggcctc ggggagggca ccccctaaga ccacagtggc caagatcaca gtggccacgg    420

ccacggccac agtcatggtg gccacggcca cagccactaa tcaggaggcc aggccaccct    480

gcctctaccc aaccagggcc ccggggcctg ttatgtcaaa ctgtcttggc tgtggggcta    540

ggggctgggg ccaaataaag tctcttcctc caagtcaaaa aaaaaa                   586


<210>  64
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile 
1               5                   10                  15      


Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu 
            20                  25                  30          


Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe 
        35                  40                  45              


Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu 
    50                  55                  60                  


Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile 
65                  70                  75                  80  


Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu 
                85                  90                  95      


Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly 
            100                 105                 110         


Thr Pro 
        


<210>  65
<211>  2058
<212>  DNA
<213>  Homo sapiens

<400>  65
gcacgaggaa gccacagatc tcttaagaac tttctgtctc caaaccgtgg ctgctcgata     60

aatcagacag aacagttaat cctcaattta agcctgatct aacccctaga aacagatata    120

gaacaatgga agtgacaaca agattgacat ggaatgatga aaatcatctg cgcaactgct    180

tggaaatgtt tctttgagtc ttctctataa gtctagtgtt catggaggta gcattgaaga    240

tatggttgaa agatgcagcc gtcagggatg tactataaca atggcttaca ttgattacaa    300

tatgattgta gcctttatgc ttggaaatta tattaattta cgtgaaagtt ctacagagcc    360

aaatgattcc ctatggtttt cacttcaaaa gaaaaatgac accactgaaa tagaaacttt    420

actcttaaat acagcaccaa aaattattga tgagcaactg gtgtgtcgtt tatcgaaaac    480

ggatattttc attatatgtc gagataataa aatttatcta gataaaatga taacaagaaa    540

cttgaaacta aggttttatg gccaccgtca gtatttggaa tgtgaagttt ttcgagttga    600

aggaattaag gataacctag acgacataaa gaggataatt aaagccagag agcacagaaa    660

taggcttcta gcagacatca gagactatag gccctatgca gacttggttt cagaaattcg    720

tattcttttg gtgggtccag ttgggtctgg aaagtccagt tttttcaatt cagtcaagtc    780

tatttttcat ggccatgtga ctggccaagc cgtagtgggg tctgatacca ccagcataac    840

cgagcggtat aggatatatt ctgttaaaga tggaaaaaat ggaaaatctc tgccatttat    900

gttgtgtgac actatggggc tagatggggc agaaggagca ggactgtgca tggatgacat    960

tccccacatc ttaaaaggtt gtatgccaga cagatatcag tttaattccc gtaaaccaat   1020

tacacctgag cattctactt ttatcacctc tccatctctg aaggacagga ttcactgtgt   1080

ggcttatgtc ttagacatca actctattga caatctctac tctaaaatgt tggcaaaagt   1140

gaagcaagtt cacaaagaag tattaaactg tggtatagca tatgtggcct tgcttactaa   1200

agtggatgat tgcagtgagg ttcttcaaga caacttttta aacatgagta gatctatgac   1260

ttctcaaagc cgggtcatga atgtccataa aatgctaggc attcctattt ccaatatttt   1320

gatggttgga aattatgctt cagatttgga actggacccc atgaaggata ttctcatcct   1380

ctctgcactg aggcagatgc tgcgggctgc agatgatttt ttagaagatt tgcctcttga   1440

ggaaactggt gcaattgaga gagcgttaca gccctgcatt tgagataagt tgccttgatt   1500

ctgacatttg gcccagcctg tactggtgtg ccgcaatgag agtcaatctc tattgacagc   1560

ctgcttcaga ttttgctttt gttcgttttg ccttctgtcc ttggaacagt catatctcaa   1620

gttcaaaggc caaaacctga gaagcggtgg gctaagatag gtcctactgc aaaccacccc   1680

tccatatttc cgtaccattt acaattcagt ttctgtgaca tctttttaaa ccactggagg   1740

aaaaatgaga tattctctaa tttattcttc tataacactc tatatagagc tatgtgagta   1800

ctaatcacat tgaataatag ttataaaatt attgtataga catctgcttc ttaaacagat   1860

tgtgagttct ttgagaaaca gcgtggattt tacttatctg tgtattcaca gagcttagca   1920

cagtgcctgg taatgagcaa gcatacttgc cattactttt ccttcccact ctctccaaca   1980

tcacattcac tttaaatttt tctgtatata gaaaggaaaa ctagcctggg caacatgatg   2040

aaaccccatc tccactgc                                                 2058


<210>  66
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Val Glu Arg Cys Ser Arg Gln Gly Cys Thr Ile Thr Met Ala Tyr 
1               5                   10                  15      


Ile Asp Tyr Asn Met Ile Val Ala Phe Met Leu Gly Asn Tyr Ile Asn 
            20                  25                  30          


Leu Arg Glu Ser Ser Thr Glu Pro Asn Asp Ser Leu Trp Phe Ser Leu 
        35                  40                  45              


Gln Lys Lys Asn Asp Thr Thr Glu Ile Glu Thr Leu Leu Leu Asn Thr 
    50                  55                  60                  


Ala Pro Lys Ile Ile Asp Glu Gln Leu Val Cys Arg Leu Ser Lys Thr 
65                  70                  75                  80  


Asp Ile Phe Ile Ile Cys Arg Asp Asn Lys Ile Tyr Leu Asp Lys Met 
                85                  90                  95      


Ile Thr Arg Asn Leu Lys Leu Arg Phe Tyr Gly His Arg Gln Tyr Leu 
            100                 105                 110         


Glu Cys Glu Val Phe Arg Val Glu Gly Ile Lys Asp Asn Leu Asp Asp 
        115                 120                 125             


Ile Lys Arg Ile Ile Lys Ala Arg Glu His Arg Asn Arg Leu Leu Ala 
    130                 135                 140                 


Asp Ile Arg Asp Tyr Arg Pro Tyr Ala Asp Leu Val Ser Glu Ile Arg 
145                 150                 155                 160 


Ile Leu Leu Val Gly Pro Val Gly Ser Gly Lys Ser Ser Phe Phe Asn 
                165                 170                 175     


Ser Val Lys Ser Ile Phe His Gly His Val Thr Gly Gln Ala Val Val 
            180                 185                 190         


Gly Ser Asp Thr Thr Ser Ile Thr Glu Arg Tyr Arg Ile Tyr Ser Val 
        195                 200                 205             


Lys Asp Gly Lys Asn Gly Lys Ser Leu Pro Phe Met Leu Cys Asp Thr 
    210                 215                 220                 


Met Gly Leu Asp Gly Ala Glu Gly Ala Gly Leu Cys Met Asp Asp Ile 
225                 230                 235                 240 


Pro His Ile Leu Lys Gly Cys Met Pro Asp Arg Tyr Gln Phe Asn Ser 
                245                 250                 255     


Arg Lys Pro Ile Thr Pro Glu His Ser Thr Phe Ile Thr Ser Pro Ser 
            260                 265                 270         


Leu Lys Asp Arg Ile His Cys Val Ala Tyr Val Leu Asp Ile Asn Ser 
        275                 280                 285             


Ile Asp Asn Leu Tyr Ser Lys Met Leu Ala Lys Val Lys Gln Val His 
    290                 295                 300                 


Lys Glu Val Leu Asn Cys Gly Ile Ala Tyr Val Ala Leu Leu Thr Lys 
305                 310                 315                 320 


Val Asp Asp Cys Ser Glu Val Leu Gln Asp Asn Phe Leu Asn Met Ser 
                325                 330                 335     


Arg Ser Met Thr Ser Gln Ser Arg Val Met Asn Val His Lys Met Leu 
            340                 345                 350         


Gly Ile Pro Ile Ser Asn Ile Leu Met Val Gly Asn Tyr Ala Ser Asp 
        355                 360                 365             


Leu Glu Leu Asp Pro Met Lys Asp Ile Leu Ile Leu Ser Ala Leu Arg 
    370                 375                 380                 


Gln Met Leu Arg Ala Ala Asp Asp Phe Leu Glu Asp Leu Pro Leu Glu 
385                 390                 395                 400 


Glu Thr Gly Ala Ile Glu Arg Ala Leu Gln Pro Cys Ile 
                405                 410             


<210>  67
<211>  3295
<212>  DNA
<213>  Homo sapiens

<400>  67
tggagaggga caggaggaaa cgcagcgcca gcagcatctc atctaccctc cttgacacct     60

ccccgtggct ccagccagac cctagaggtc agccttgcgg accaacagga ggactcccag    120

ctttcccttt tcaagaggtc cccagacacc ggccaccctc ttccagcccc tgcggccagt    180

gcaaggaggc accaatgctc tgaggctgtc gcgtggtgca gcgtcgagca tcctcgccga    240

ggtcctttct gctgcctgtc ccgcctcacc ccgctccatc acaccagctg gccctctttg    300

cttccttttc ccagaatcgt taagccccga ctcccactag cacctcgtac caacctcgcc    360

ccaccccatc ctcctgcctt cccgcgctcc ggtgtccccc gctgccatga gctcccccat    420

cagcaagagc cgctcgcttg ccgccttcct gcagcagctg cgcagtccga ggcagccccc    480

gagactggtg acatctacgg cgtacacgtc ccctcagccg cgagaggtgc cagtctgccc    540

gctgacagct ggtggcgaga ctcagaacgc ggccgccctg ccgggcccca ccagctggcc    600

actgctgggc agcctgctgc agattctctg gaaagggggt ctcaagaaac agcacgacac    660

cctggtggag taccacaaga agtatggcaa gattttccgc atgaagttgg gttcctttga    720

gtcggtgcac ctgggctcgc catgcctgct ggaagcgctg taccgcaccg agagcgcgta    780

cccgcagcgg ctggagatca aaccgtggaa ggcctatcgc gactaccgca aagaaggcta    840

cgggctgctg atcctggaag gggaagactg gcagcgggtc cggagtgcct ttcaaaagaa    900

actaatgaaa ccaggggaag tgatgaagct ggacaacaaa atcaatgagg tcttggccga    960

ttttatgggc agaatagatg agctctgtga tgaaagaggc cacgtcgaag acttgtacag   1020

cgaactgaac aaatggtcgt ttgaaagtat ctgcctcgtg ttgtatgaga agagatttgg   1080

gcttctccag aagaatgcag gggatgaagc tgtgaacttc atcatggcca tcaaaacaat   1140

gatgagcacg tttgggagga tgatggtcac tccagtcgag ctgcacaaga gcctcaacac   1200

caaggtctgg caggaccaca ctctggcctg ggacaccatt ttcaaatcag tcaaagcttg   1260

tatcgacaac cggttagaga agtattctca gcagcctagt gcagatttcc tttgtgacat   1320

ttatcaccag aatcggcttt caaagaaaga attgtatgct gctgtcacag agctccagct   1380

ggctgcggtg gaaacgacag caaacagtct aatgtggatt ctctacaatt tatcccgtaa   1440

tccccaagtg caacaaaagc ttcttaagga aattcaaagt gtattacctg agaatcaggt   1500

gccacgggca gaagatttga ggaatatgcc gtatttaaaa gcctgtctga aagaatctat   1560

gaggcttacg ccgagtgtac catttacaac tcggactctt gacaaggcaa cagttctggg   1620

tgaatatgct ttacccaaag gaacagtgct catgctaaat acccaggtgt tgggatccag   1680

tgaagacaat tttgaagatt caagtcagtt tagacctgaa cgttggcttc aggagaagga   1740

aaaaattaat ccttttgcgc atcttccatt tggcgttgga aaaagaatgt gcattggtcg   1800

ccgattagca gagcttcaac tgcatttggc tctttgttgg attgtccgca aatacgacat   1860

ccaggccaca gacaatgagc ctgttgagat gctacactca ggcaccctgg tgcccagccg   1920

ggaactcccc atcgcgtttt gccagcgata atacgcctca gatggtggta tttgctaaca   1980

tcatatccaa ctcagggaag cggactgagt gctgggatcc aaggcattct acagggttca   2040

ctgctggttt acacttcacc tgtgtcagca ccatcttcag gtgcttagaa tggcctggga   2100

gcctgttctg tcttgcatct tccatgacat gaaagggagg ctggcacttg tcagtcaggt   2160

agaggttaca aaccgtttca ggccctgcct accacattca ctgtttgaat ctttaattcc   2220

caagaataag tttacatttc acaatgaatg acctacaaca gctaaatttt ctggggctgg   2280

gagtaatact gacaatccat ttactgtagc tctgcttaat gtactactta ggaaaatgtc   2340

cctgcttaat aatgtaagcc aagctaaatg atggttaaag ttatcaggcc tcccatgaaa   2400

ttgcgttctt cctgcattga aataaaaaca ttattgggaa actagagaac acctctattt   2460

ttaaaaggac tttaacgaag tcaaacaact tataagacta gtgattcact ggggcattat   2520

tttgttagag gaccttaaaa ttgtttattt tttaaatgtg attcctttat ggcattaggg   2580

taaagatgaa gcaataattt ttaaattgtg tatgtgcata tgaagcacag acatgcatgt   2640

gtgtgtgtgt ctgtgtgtgt gtgtccgtgt atgtgtgtgt gggttctaat ggtaatttgc   2700

ctcagtcatt tttttaatat ttgcagtact tgatttagga tctgtggtgc agggcaatgt   2760

ttcaaagttt agtcacagct taaaaacatt cagtgtgact ttaatattat aaaatgattt   2820

cccatgccat aatttttctg tctattaaat gggacaagtg taaagcatgc aaaagttaga   2880

gatctgttat ataacatttg ttttgtgatt tgaactccta ggaaaaatat gatttcataa   2940

atgtaaaatg cacagaaatg catgcaatac ttataagact taaaaattgt gtttacagat   3000

ggtttatttg tgcatatttt tactactgct tttcctaaat gcatactgta tataattctg   3060

tgtatttgat aaatatttct tcctacatta tatttttaga atatttcaga aatatacatt   3120

tatgtcttta tattgtaata aatatgtaca tatctaggta tatgctttct ctctgctgtg   3180

aaattatttt tagaattata aattcacgtc ttgtcagatt tcatctgtat accttcaaat   3240

tctctgaaag taaaaataaa agtttttaaa tattaaaaaa aaaaaaaaaa aaaaa        3295


<210>  68
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ser Ser Pro Ile Ser Lys Ser Arg Ser Leu Ala Ala Phe Leu Gln 
1               5                   10                  15      


Gln Leu Arg Ser Pro Arg Gln Pro Pro Arg Leu Val Thr Ser Thr Ala 
            20                  25                  30          


Tyr Thr Ser Pro Gln Pro Arg Glu Val Pro Val Cys Pro Leu Thr Ala 
        35                  40                  45              


Gly Gly Glu Thr Gln Asn Ala Ala Ala Leu Pro Gly Pro Thr Ser Trp 
    50                  55                  60                  


Pro Leu Leu Gly Ser Leu Leu Gln Ile Leu Trp Lys Gly Gly Leu Lys 
65                  70                  75                  80  


Lys Gln His Asp Thr Leu Val Glu Tyr His Lys Lys Tyr Gly Lys Ile 
                85                  90                  95      


Phe Arg Met Lys Leu Gly Ser Phe Glu Ser Val His Leu Gly Ser Pro 
            100                 105                 110         


Cys Leu Leu Glu Ala Leu Tyr Arg Thr Glu Ser Ala Tyr Pro Gln Arg 
        115                 120                 125             


Leu Glu Ile Lys Pro Trp Lys Ala Tyr Arg Asp Tyr Arg Lys Glu Gly 
    130                 135                 140                 


Tyr Gly Leu Leu Ile Leu Glu Gly Glu Asp Trp Gln Arg Val Arg Ser 
145                 150                 155                 160 


Ala Phe Gln Lys Lys Leu Met Lys Pro Gly Glu Val Met Lys Leu Asp 
                165                 170                 175     


Asn Lys Ile Asn Glu Val Leu Ala Asp Phe Met Gly Arg Ile Asp Glu 
            180                 185                 190         


Leu Cys Asp Glu Arg Gly His Val Glu Asp Leu Tyr Ser Glu Leu Asn 
        195                 200                 205             


Lys Trp Ser Phe Glu Ser Ile Cys Leu Val Leu Tyr Glu Lys Arg Phe 
    210                 215                 220                 


Gly Leu Leu Gln Lys Asn Ala Gly Asp Glu Ala Val Asn Phe Ile Met 
225                 230                 235                 240 


Ala Ile Lys Thr Met Met Ser Thr Phe Gly Arg Met Met Val Thr Pro 
                245                 250                 255     


Val Glu Leu His Lys Ser Leu Asn Thr Lys Val Trp Gln Asp His Thr 
            260                 265                 270         


Leu Ala Trp Asp Thr Ile Phe Lys Ser Val Lys Ala Cys Ile Asp Asn 
        275                 280                 285             


Arg Leu Glu Lys Tyr Ser Gln Gln Pro Ser Ala Asp Phe Leu Cys Asp 
    290                 295                 300                 


Ile Tyr His Gln Asn Arg Leu Ser Lys Lys Glu Leu Tyr Ala Ala Val 
305                 310                 315                 320 


Thr Glu Leu Gln Leu Ala Ala Val Glu Thr Thr Ala Asn Ser Leu Met 
                325                 330                 335     


Trp Ile Leu Tyr Asn Leu Ser Arg Asn Pro Gln Val Gln Gln Lys Leu 
            340                 345                 350         


Leu Lys Glu Ile Gln Ser Val Leu Pro Glu Asn Gln Val Pro Arg Ala 
        355                 360                 365             


Glu Asp Leu Arg Asn Met Pro Tyr Leu Lys Ala Cys Leu Lys Glu Ser 
    370                 375                 380                 


Met Arg Leu Thr Pro Ser Val Pro Phe Thr Thr Arg Thr Leu Asp Lys 
385                 390                 395                 400 


Ala Thr Val Leu Gly Glu Tyr Ala Leu Pro Lys Gly Thr Val Leu Met 
                405                 410                 415     


Leu Asn Thr Gln Val Leu Gly Ser Ser Glu Asp Asn Phe Glu Asp Ser 
            420                 425                 430         


Ser Gln Phe Arg Pro Glu Arg Trp Leu Gln Glu Lys Glu Lys Ile Asn 
        435                 440                 445             


Pro Phe Ala His Leu Pro Phe Gly Val Gly Lys Arg Met Cys Ile Gly 
    450                 455                 460                 


Arg Arg Leu Ala Glu Leu Gln Leu His Leu Ala Leu Cys Trp Ile Val 
465                 470                 475                 480 


Arg Lys Tyr Asp Ile Gln Ala Thr Asp Asn Glu Pro Val Glu Met Leu 
                485                 490                 495     


His Ser Gly Thr Leu Val Pro Ser Arg Glu Leu Pro Ile Ala Phe Cys 
            500                 505                 510         


Gln Arg 
        


<210>  69
<211>  2741
<212>  DNA
<213>  Homo sapiens

<400>  69
ggacttcgcc agatcagacc cacggggctg ccctcccctg cgcactcccc tcgctgcccg     60

ggcccggagc gcagcgcggc cgcacaggta tttttgctgt gctgtgcaag gaactctgct    120

agctcaagat tcacaatgtt gaaagccctt ttcctaacta tgctgactct ggcgctggtc    180

aagtcacagg acaccgaaga aaccatcacg tacacgcaat gcactgacgg atatgagtgg    240

gatcctgtga gacagcaatg caaagatatt gatgaatgtg acattgtccc agacgcttgt    300

aaaggtggaa tgaagtgtgt caaccactat ggaggatacc tctgccttcc gaaaacagcc    360

cagattattg tcaataatga acagcctcag caggaaacac aaccagcaga aggaacctca    420

ggggcaacca ccggggttgt agctgccagc agcatggcaa ccagtggagt gttgcccggg    480

ggtggttttg tggccagtgc tgctgcagtc gcaggccctg aaatgcagac tggccgaaat    540

aactttgtca tccggcggaa cccagctgac cctcagcgca ttccctccaa cccttcccac    600

cgtatccagt gtgcagcagg ctacgagcaa agtgaacaca acgtgtgcca agacatagac    660

gagtgcactg cagggacgca caactgtaga gcagaccaag tgtgcatcaa tttacgggga    720

tcctttgcat gtcagtgccc tcctggatat cagaagcgag gggagcagtg cgtagacata    780

gatgaatgta ccatccctcc atattgccac caaagatgcg tgaatacacc aggctcattt    840

tattgccagt gcagtcctgg gtttcaattg gcagcaaaca actatacctg cgtagatata    900

aatgaatgtg atgccagcaa tcaatgtgct cagcagtgct acaacattct tggttcattc    960

atctgtcagt gcaatcaagg atatgagcta agcagtgaca ggctcaactg tgaagacatt   1020

gatgaatgca gaacctcaag ctacctgtgt caatatcaat gtgtcaatga acctgggaaa   1080

ttctcatgta tgtgccccca gggataccaa gtggtgagaa gtagaacatg tcaagatata   1140

aatgagtgtg agaccacaaa tgaatgccgg gaggatgaaa tgtgttggaa ttatcatggc   1200

ggcttccgtt gttatccacg aaatccttgt caagatccct acattctaac accagagaac   1260

cgatgtgttt gcccagtctc aaatgccatg tgccgagaac tgccccagtc aatagtctac   1320

aaatacatga gcatccgatc tgataggtct gtgccatcag acatcttcca gatacaggcc   1380

acaactattt atgccaacac catcaatact tttcggatta aatctggaaa tgaaaatgga   1440

gagttctacc tacgacaaac aagtcctgta agtgcaatgc ttgtgctcgt gaagtcatta   1500

tcaggaccaa gagaacatat cgtggacctg gagatgctga cagtcagcag tatagggacc   1560

ttccgcacaa gctctgtgtt aagattgaca ataatagtgg ggccattttc attttagtct   1620

tttctaagag tcaaccacag gcatttaagt cagccaaaga atattgttac cttaaagcac   1680

tattttattt atagatatat ctagtgcatc tacatctcta tactgtacac tcacccataa   1740

ttcaaacaat tacaccatgg tataaagtgg gcatttaata tgtaaagatt caaagtttgt   1800

ctttattact atatgtaaat tagacattaa tccactaaac tggtcttctt caagagagct   1860

aagtatacac tatctggtga aacttggatt ctttcctata aaagtgggac caagcaatga   1920

tgatcttctg tggtgcttaa ggaaacttac tagagctcca ctaacagtct cataaggagg   1980

cagccatcat aaccattgaa tagcatgcaa gggtaagaat gagtttttaa ctgctttgta   2040

agaaaatgga aaaggtcaat aaagatatat ttctttagaa aatggggatc tgccatattt   2100

gtgttggttt ttattttcat atccagccta aaggtggttg tttattatat agtaataaat   2160

cattgctgta caatatgctg gtttctgtag ggtattttta attttgtcag aaattttaga   2220

ttgtgaatat tttgtaaaaa acagtaagca aaattttcca gaattcccaa aatgaaccag   2280

atatccccta gaaaattata ctattgagaa atctatgggg aggatatgag aaaataaatt   2340

ccttctaaac cacattggaa ctgacctgaa gaagcaaact cggaaaatat aataacatcc   2400

ctgaattcag gacttccaca agatgcagaa caaaatggat aaaaggtatt tcactggaga   2460

agttttaatt tctaagtaaa atttaaatcc taacacttca ctaatttata actaaaattt   2520

ctcatcttcg tacttgatgc tcacagagga agaaaatgat gatggttttt attcctggca   2580

tccagagtga cagtgaactt aagcaaatta ccctcctacc caattctatg gaatatttta   2640

tacgtctcct tgtttaaaat gtcactgctt tactttgatg tatcatattt ttaaataaaa   2700

ataaatattc ctttagaaga tcaaaaaaaa aaaaaaaaaa a                       2741


<210>  70
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
    50                  55                  60                  


Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
65                  70                  75                  80  


Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                85                  90                  95      


Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
            100                 105                 110         


Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
        115                 120                 125             


Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
    130                 135                 140                 


Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
145                 150                 155                 160 


Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                165                 170                 175     


Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn 
            180                 185                 190         


Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg 
        195                 200                 205             


Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys 
    210                 215                 220                 


His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser 
225                 230                 235                 240 


Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                245                 250                 255     


Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
            260                 265                 270         


Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
        275                 280                 285             


Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
305                 310                 315                 320 


Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                325                 330                 335     


Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
            340                 345                 350         


Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro 
        355                 360                 365             


Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala 
    370                 375                 380                 


Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile 
385                 390                 395                 400 


Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                405                 410                 415     


Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
            420                 425                 430         


Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
        435                 440                 445             


Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp 
    450                 455                 460                 


Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
465                 470                 475                 480 


Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                485                 490             


<210>  71
<211>  853
<212>  DNA
<213>  Homo sapiens

<400>  71
ctagtcctga cttcacttct gatgaggaag cctctctcct tagccttcag cctttcctcc     60

caccctgcca taagtaattt gatcctcaag aagttaaacc acacctcatt ggtccctggc    120

taattcacca atttacaaac agcaggaaat agaaacttaa gagaaataca cacttctgag    180

aaactgaaac gacaggggaa aggaggtctc actgagcacc gtcccagcat ccggacacca    240

cagcggccct tcgctccacg cagaaaacca cacttctcaa accttcactc aacacttcct    300

tccccaaagc cagaagatgc acaaggagga acatgaggtg gctgtgctgg gggcaccccc    360

cagcaccatc cttccaaggt ccaccgtgat caacatccac agcgagacct ccgtgcccga    420

ccatgtcgtc tggtccctgt tcaacaccct cttcttgaac tggtgctgtc tgggcttcat    480

agcattcgcc tactccgtga agtctaggga caggaagatg gttggcgacg tgaccggggc    540

ccaggcctat gcctccaccg ccaagtgcct gaacatctgg gccctgattc tgggcatcct    600

catgaccatt ggattcatcc tgtcactggt attcggctct gtgacagtct accatattat    660

gttacagata atacaggaaa aacggggtta ctagtagccg cccatagcct gcaacctttg    720

cactccactg tgcaatgctg gccctgcacg ctggggctgt tgcccctgcc cccttggtcc    780

tgcccctaga tacagcagtt tatacccaca cacctgtcta cagtgtcatt caataaagtg    840

cacgtgcttg tga                                                       853


<210>  72
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  72

Met His Lys Glu Glu His Glu Val Ala Val Leu Gly Ala Pro Pro Ser 
1               5                   10                  15      


Thr Ile Leu Pro Arg Ser Thr Val Ile Asn Ile His Ser Glu Thr Ser 
            20                  25                  30          


Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr Leu Phe Leu Asn 
        35                  40                  45              


Trp Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys Ser Arg 
    50                  55                  60                  


Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln Ala Tyr Ala Ser 
65                  70                  75                  80  


Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu Gly Ile Leu Met 
                85                  90                  95      


Thr Ile Gly Phe Ile Leu Ser Leu Val Phe Gly Ser Val Thr Val Tyr 
            100                 105                 110         


His Ile Met Leu Gln Ile Ile Gln Glu Lys Arg Gly Tyr 
        115                 120                 125 


<210>  73
<211>  5175
<212>  DNA
<213>  Homo sapiens

<400>  73
acagcggagc gcagagtgag aaccaccaac cgaggcgccg ggcagcgacc cctgcagcgg     60

agacagagac tgagcggccc ggcaccgcca tgcctgcgct ctggctgggc tgctgcctct    120

gcttctcgct cctcctgccc gcagcccggg ccacctccag gagggaagtc tgtgattgca    180

atgggaagtc caggcagtgt atctttgatc gggaacttca cagacaaact ggtaatggat    240

tccgctgcct caactgcaat gacaacactg atggcattca ctgcgagaag tgcaagaatg    300

gcttttaccg gcacagagaa agggaccgct gtttgccctg caattgtaac tccaaaggtt    360

ctcttagtgc tcgatgtgac aactctggac ggtgcagctg taaaccaggt gtgacaggag    420

ccagatgcga ccgatgtctg ccaggcttcc acatgctcac ggatgcgggg tgcacccaag    480

accagagact gctagactcc aagtgtgact gtgacccagc tggcatcgca gggccctgtg    540

acgcgggccg ctgtgtctgc aagccagctg ttactggaga acgctgtgat aggtgtcgat    600

caggttacta taatctggat ggggggaacc ctgagggctg tacccagtgt ttctgctatg    660

ggcattcagc cagctgccgc agctctgcag aatacagtgt ccataagatc acctctacct    720

ttcatcaaga tgttgatggc tggaaggctg tccaacgaaa tgggtctcct gcaaagctcc    780

aatggtcaca gcgccatcaa gatgtgttta gctcagccca acgactagac cctgtctatt    840

ttgtggctcc tgccaaattt cttgggaatc aacaggtgag ctatgggcaa agcctgtcct    900

ttgactaccg tgtggacaga ggaggcagac acccatctgc ccatgatgtg attctggaag    960

gtgctggtct acggatcaca gctcccttga tgccacttgg caagacactg ccttgtgggc   1020

tcaccaagac ttacacattc aggttaaatg agcatccaag caataattgg agcccccagc   1080

tgagttactt tgagtatcga aggttactgc ggaatctcac agccctccgc atccgagcta   1140

catatggaga atacagtact gggtacattg acaatgtgac cctgatttca gcccgccctg   1200

tctctggagc cccagcaccc tgggttgaac agtgtatatg tcctgttggg tacaaggggc   1260

aattctgcca ggattgtgct tctggctaca agagagattc agcgagactg gggccttttg   1320

gcacctgtat tccttgtaac tgtcaagggg gaggggcctg tgatccagac acaggagatt   1380

gttattcagg ggatgagaat cctgacattg agtgtgctga ctgcccaatt ggtttctaca   1440

acgatccgca cgacccccgc agctgcaagc catgtccctg tcataacggg ttcagctgct   1500

cagtgatgcc ggagacggag gaggtggtgt gcaataactg ccctcccggg gtcaccggtg   1560

cccgctgtga gctctgtgct gatggctact ttggggaccc ctttggtgaa catggcccag   1620

tgaggccttg tcagccctgt caatgcaaca acaatgtgga ccccagtgcc tctgggaatt   1680

gtgaccggct gacaggcagg tgtttgaagt gtatccacaa cacagccggc atctactgcg   1740

accagtgcaa agcaggctac ttcggggacc cattggctcc caacccagca gacaagtgtc   1800

gagcttgcaa ctgtaacccc atgggctcag agcctgtagg atgtcgaagt gatggcacct   1860

gtgtttgcaa gccaggattt ggtggcccca actgtgagca tggagcattc agctgtccag   1920

cttgctataa tcaagtgaag attcagatgg atcagtttat gcagcagctt cagagaatgg   1980

aggccctgat ttcaaaggct cagggtggtg atggagtagt acctgataca gagctggaag   2040

gcaggatgca gcaggctgag caggcccttc aggacattct gagagatgcc cagatttcag   2100

aaggtgctag cagatccctt ggtctccagt tggccaaggt gaggagccaa gagaacagct   2160

accagagccg cctggatgac ctcaagatga ctgtggaaag agttcgggct ctgggaagtc   2220

agtaccagaa ccgagttcgg gatactcaca ggctcatcac tcagatgcag ctgagcctgg   2280

cagaaagtga agcttccttg ggaaacacta acattcctgc ctcagaccac tacgtggggc   2340

caaatggctt taaaagtctg gctcaggagg ccacaagatt agcagaaagc cacgttgagt   2400

cagccagtaa catggagcaa ctgacaaggg aaactgagga ctattccaaa caagccctct   2460

cactggtgcg caaggccctg catgaaggag tcggaagcgg aagcggtagc ccggacggtg   2520

ctgtggtgca agggcttgtg gaaaaattgg agaaaaccaa gtccctggcc cagcagttga   2580

caagggaggc cactcaagcg gaaattgaag cagataggtc ttatcagcac agtctccgcc   2640

tcctggattc agtgtctcgg cttcagggag tcagtgatca gtcctttcag gtggaagaag   2700

caaagaggat caaacaaaaa gcggattcac tctcaacgct ggtaaccagg catatggatg   2760

agttcaagcg tacacaaaag aatctgggaa actggaaaga agaagcacag cagctcttac   2820

agaatggaaa aagtgggaga gagaaatcag atcagctgct ttcccgtgcc aatcttgcta   2880

aaagcagagc acaagaagca ctgagtatgg gcaatgccac tttttatgaa gttgagagca   2940

tccttaaaaa cctcagagag tttgacctgc aggtggacaa cagaaaagca gaagctgaag   3000

aagccatgaa gagactctcc tacatcagcc agaaggtttc agatgccagt gacaagaccc   3060

agcaagcaga aagagccctg gggagcgctg ctgctgatgc acagagggca aagaatgggg   3120

ccggggaggc cctggaaatc tccagtgaga ttgaacagga gattgggagt ctgaacttgg   3180

aagccaatgt gacagcagat ggagccttgg ccatggaaaa gggactggcc tctctgaaga   3240

gtgagatgag ggaagtggaa ggagagctgg aaaggaagga gctggagttt gacacgaata   3300

tggatgcagt acagatggtg attacagaag cccagaaggt tgataccaga gccaagaacg   3360

ctggggttac aatccaagac acactcaaca cattagacgg cctcctgcat ctgatggacc   3420

agcctctcag tgtagatgaa gaggggctgg tcttactgga gcagaagctt tcccgagcca   3480

agacccagat caacagccaa ctgcggccca tgatgtcaga gctggaagag agggcacgtc   3540

agcagagggg ccacctccat ttgctggaga caagcataga tgggattctg gctgatgtga   3600

agaacttgga gaacattagg gacaacctgc ccccaggctg ctacaatacc caggctcttg   3660

agcaacagtg aagctgccat aaatatttct caactgaggt tcttgggata cagatctcag   3720

ggctcgggag ccatgtcatg tgagtgggtg ggatggggac atttgaacat gtttaatggg   3780

tatgctcagg tcaactgacc tgaccccatt cctgatccca tggccaggtg gttgtcttat   3840

tgcaccatac tccttgcttc ctgatgctgg gcaatgaggc agatagcact gggtgtgaga   3900

atgatcaagg atctggaccc caaagaatag actggatgga aagacaaact gcacaggcag   3960

atgtttgcct cataatagtc gtaagtggag tcctggaatt tggacaagtg ctgttgggat   4020

atagtcaact tattctttga gtaatgtgac taaaggaaaa aactttgact ttgcccaggc   4080

atgaaattct tcctaatgtc agaacagagt gcaacccagt cacactgtgg ccagtaaaat   4140

actattgcct catattgtcc tctgcaagct tcttgctgat cagagttcct cctacttaca   4200

acccagggtg tgaacatgtt ctccattttc aagctggaag aagtgagcag tgttggagtg   4260

aggacctgta aggcaggccc attcagagct atggtgcttg ctggtgcctg ccaccttcaa   4320

gttctggacc tgggcatgac atcctttctt ttaatgatgc catggcaact tagagattgc   4380

atttttatta aagcatttcc taccagcaaa gcaaatgttg ggaaagtatt tactttttcg   4440

gtttcaaagt gatagaaaag tgtggcttgg gcattgaaag aggtaaaatt ctctagattt   4500

attagtccta attcaatcct acttttcgaa caccaaaaat gatgcgcatc aatgtatttt   4560

atcttatttt ctcaatctcc tctctctttc ctccacccat aataagagaa tgttcctact   4620

cacacttcag ctgggtcaca tccatccctc cattcatcct tccatccatc tttccatcca   4680

ttacctccat ccatccttcc aacatatatt tattgagtac ctactgtgtg ccaggggctg   4740

gtgggacagt ggtgacatag tctctgccct catagagttg attgtctagt gaggaagaca   4800

agcattttta aaaaataaat ttaaacttac aaactttgtt tgtcacaagt ggtgtttatt   4860

gcaataaccg cttggtttgc aacctctttg ctcaacagaa catatgttgc aagaccctcc   4920

catgggggca cttgagtttt ggcaaggctg acagagctct gggttgtgca catttctttg   4980

cattccagct gtcactctgt gcctttctac aactgattgc aacagactgt tgagttatga   5040

taacaccagt gggaattgct ggaggaacca gaggcacttc caccttggct gggaagacta   5100

tggtgctgcc ttgcttctgt atttccttgg attttcctga aagtgttttt aaataaagaa   5160

caattgttag atgcc                                                    5175


<210>  74
<211>  1193
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Pro Ala Leu Trp Leu Gly Cys Cys Leu Cys Phe Ser Leu Leu Leu 
1               5                   10                  15      


Pro Ala Ala Arg Ala Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly 
            20                  25                  30          


Lys Ser Arg Gln Cys Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly 
        35                  40                  45              


Asn Gly Phe Arg Cys Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His 
    50                  55                  60                  


Cys Glu Lys Cys Lys Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg 
65                  70                  75                  80  


Cys Leu Pro Cys Asn Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys 
                85                  90                  95      


Asp Asn Ser Gly Arg Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg 
            100                 105                 110         


Cys Asp Arg Cys Leu Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys 
        115                 120                 125             


Thr Gln Asp Gln Arg Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala 
    130                 135                 140                 


Gly Ile Ala Gly Pro Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala 
145                 150                 155                 160 


Val Thr Gly Glu Arg Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu 
                165                 170                 175     


Asp Gly Gly Asn Pro Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His 
            180                 185                 190         


Ser Ala Ser Cys Arg Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr 
        195                 200                 205             


Ser Thr Phe His Gln Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn 
    210                 215                 220                 


Gly Ser Pro Ala Lys Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe 
225                 230                 235                 240 


Ser Ser Ala Gln Arg Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys 
                245                 250                 255     


Phe Leu Gly Asn Gln Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp 
            260                 265                 270         


Tyr Arg Val Asp Arg Gly Gly Arg His Pro Ser Ala His Asp Val Ile 
        275                 280                 285             


Leu Glu Gly Ala Gly Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly 
    290                 295                 300                 


Lys Thr Leu Pro Cys Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn 
305                 310                 315                 320 


Glu His Pro Ser Asn Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr 
                325                 330                 335     


Arg Arg Leu Leu Arg Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr 
            340                 345                 350         


Gly Glu Tyr Ser Thr Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala 
        355                 360                 365             


Arg Pro Val Ser Gly Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys 
    370                 375                 380                 


Pro Val Gly Tyr Lys Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr 
385                 390                 395                 400 


Lys Arg Asp Ser Ala Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys 
                405                 410                 415     


Asn Cys Gln Gly Gly Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr 
            420                 425                 430         


Ser Gly Asp Glu Asn Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly 
        435                 440                 445             


Phe Tyr Asn Asp Pro His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys 
    450                 455                 460                 


His Asn Gly Phe Ser Cys Ser Val Met Pro Glu Thr Glu Glu Val Val 
465                 470                 475                 480 


Cys Asn Asn Cys Pro Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys 
                485                 490                 495     


Ala Asp Gly Tyr Phe Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg 
            500                 505                 510         


Pro Cys Gln Pro Cys Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser 
        515                 520                 525             


Gly Asn Cys Asp Arg Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn 
    530                 535                 540                 


Thr Ala Gly Ile Tyr Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp 
545                 550                 555                 560 


Pro Leu Ala Pro Asn Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn 
                565                 570                 575     


Pro Met Gly Ser Glu Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val 
            580                 585                 590         


Cys Lys Pro Gly Phe Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser 
        595                 600                 605             


Cys Pro Ala Cys Tyr Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met 
    610                 615                 620                 


Gln Gln Leu Gln Arg Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly 
625                 630                 635                 640 


Asp Gly Val Val Pro Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala 
                645                 650                 655     


Glu Gln Ala Leu Gln Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly 
            660                 665                 670         


Ala Ser Arg Ser Leu Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu 
        675                 680                 685             


Asn Ser Tyr Gln Ser Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg 
    690                 695                 700                 


Val Arg Ala Leu Gly Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His 
705                 710                 715                 720 


Arg Leu Ile Thr Gln Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser 
                725                 730                 735     


Leu Gly Asn Thr Asn Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn 
            740                 745                 750         


Gly Phe Lys Ser Leu Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His 
        755                 760                 765             


Val Glu Ser Ala Ser Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp 
    770                 775                 780                 


Tyr Ser Lys Gln Ala Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly 
785                 790                 795                 800 


Val Gly Ser Gly Ser Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu 
                805                 810                 815     


Val Glu Lys Leu Glu Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg 
            820                 825                 830         


Glu Ala Thr Gln Ala Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser 
        835                 840                 845             


Leu Arg Leu Leu Asp Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln 
    850                 855                 860                 


Ser Phe Gln Val Glu Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser 
865                 870                 875                 880 


Leu Ser Thr Leu Val Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln 
                885                 890                 895     


Lys Asn Leu Gly Asn Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn 
            900                 905                 910         


Gly Lys Ser Gly Arg Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn 
        915                 920                 925             


Leu Ala Lys Ser Arg Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr 
    930                 935                 940                 


Phe Tyr Glu Val Glu Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu 
945                 950                 955                 960 


Gln Val Asp Asn Arg Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu 
                965                 970                 975     


Ser Tyr Ile Ser Gln Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln 
            980                 985                 990         


Ala Glu Arg Ala Leu Gly Ser Ala  Ala Ala Asp Ala Gln  Arg Ala Lys 
        995                 1000                 1005             


Asn Gly  Ala Gly Glu Ala Leu  Glu Ile Ser Ser Glu  Ile Glu Gln 
    1010                 1015                 1020             


Glu Ile  Gly Ser Leu Asn Leu  Glu Ala Asn Val Thr  Ala Asp Gly 
    1025                 1030                 1035             


Ala Leu  Ala Met Glu Lys Gly  Leu Ala Ser Leu Lys  Ser Glu Met 
    1040                 1045                 1050             


Arg Glu  Val Glu Gly Glu Leu  Glu Arg Lys Glu Leu  Glu Phe Asp 
    1055                 1060                 1065             


Thr Asn  Met Asp Ala Val Gln  Met Val Ile Thr Glu  Ala Gln Lys 
    1070                 1075                 1080             


Val Asp  Thr Arg Ala Lys Asn  Ala Gly Val Thr Ile  Gln Asp Thr 
    1085                 1090                 1095             


Leu Asn  Thr Leu Asp Gly Leu  Leu His Leu Met Asp  Gln Pro Leu 
    1100                 1105                 1110             


Ser Val  Asp Glu Glu Gly Leu  Val Leu Leu Glu Gln  Lys Leu Ser 
    1115                 1120                 1125             


Arg Ala  Lys Thr Gln Ile Asn  Ser Gln Leu Arg Pro  Met Met Ser 
    1130                 1135                 1140             


Glu Leu  Glu Glu Arg Ala Arg  Gln Gln Arg Gly His  Leu His Leu 
    1145                 1150                 1155             


Leu Glu  Thr Ser Ile Asp Gly  Ile Leu Ala Asp Val  Lys Asn Leu 
    1160                 1165                 1170             


Glu Asn  Ile Arg Asp Asn Leu  Pro Pro Gly Cys Tyr  Asn Thr Gln 
    1175                 1180                 1185             


Ala Leu  Glu Gln Gln 
    1190             


<210>  75
<211>  2210
<212>  DNA
<213>  Homo sapiens

<400>  75
gtccagagcc ttgcctgctt gtgatcctgg tggagaaggt ggagtatggt gagctgcttg     60

ctaaggacag ccaggcaaca ctgtgtttgt gaagatgtgc tccaccttct cctctgtgca    120

tcccagctcc tcctgctgaa acagctgagc ttgctttttg gatttcttag actcctggcc    180

tctgagagac acctctaagg acaaactgac cttgcattgg gaactttatt atccagatcc    240

tcataggctt tgtctactct ggattgcttg ttgcaacagt tcttaggaag caagattgtc    300

tcctgcacca gcatctgcct gtgtttgctt ttacctactt tgagcaagac ccagtgaggc    360

cctagctctg ttggtcctga aaagcctgaa ccctgaggct gtttctcctg cctccaaaat    420

gcaattatag gaaataagaa gcacagaaac agtggaaaca accaggagga gaaacaggaa    480

aacctaaaat tttcaatatt caaaaatacc tgtcgtggtg gttgatgcag aaaacactga    540

gttcatcaaa gagctttgta attgttggac cagagaaccc ctttgctaca ggaactgata    600

tgttttgtct ttctggccta gtcaagggag gataagtaag tatctggggc atggaaggaa    660

tgcactcttg ggctgttttg cttgtatctg actcacccct gactctccag tgaagcagaa    720

aggaagaaac ctcacaccac ccaggtgtgg ccagactttg gccattattg tgaatcccca    780

agagttacca caggcccttc ccaaatatat atttaatctt gtggttcaaa taagcttttg    840

gctcacatct aagcacatca taaagaacgc tgtagaagag gtgacatgat gaggcgggaa    900

gacgaggaag aggagggaac aatgatgaag gcaaaagggg acttagagat gaaggaggag    960

gaagagatta gtgagacagg agaactggtt ggcccttttg tgagtgctat gcccactcca   1020

atgccccaca acaagggcac ccggttctct gaggcatggg aatatttcca cctagctcct   1080

gctcgtgctg ggcaccatcc caaccagtat gccacctgcc gcctgtgtgg caggcaggtg   1140

agccgtggcc ctggggtcaa cgtgggcacc actgcactgt ggaagcatct gaaaagcatg   1200

cacagagagg agctggagaa gagtggccat ggtcaggctg ggcagcgcca ggatccaagg   1260

ccccacgggc cccagctccc cacaggcatt gagggtaact ggggtaggct cctggagcag   1320

gtgggcacca tggctttgtg ggccagccaa agggaaaagg aggtgcttag gagggaaagg   1380

gcagtggaat ggcgggagag ggctgtggaa aaaagggagc gagccctgga ggaggtggaa   1440

agggccatcc tggagatgaa gtggaaggtg agggctgaga aggaggcatg ccagcgggag   1500

aaagagctgc ctgcagcagt acatcccttc cattttgttt aaattgggct tggagaatct   1560

attctgaaaa cattgactct agacttgtag aaaagagcca ttttagtttc aactcaaatg   1620

taaagcaaag tagtttggtg acattttgct tttatgtgaa atagtgcaca gtatgagtta   1680

atctgagcag gtctgaattg accaaatgct tatctacgag gttcctagag ctctgctgac   1740

ccttggccga aactctaaaa tgtacctatt aaagataaat gcttctacca aagtaaaact   1800

ctgtgagttg tttcagggca gaatgtacca gccagtcagc gttgtttaac aaaataatca   1860

gatttttgcc tagcactcgg ttttggtgga gctgacgatt ttgagggctg aggctggtta   1920

ggtagctgga atgtgcctat gtgaccagct cacttgcaga caccctgccg gaagcagagc   1980

ttaatcttcc taggactgag gtcttagcac atgtactggt ggagtttcca gaccaccagt   2040

atgaataaaa gcttgttctg tgtgacccag caagtggaag gacaaagaac tgtgagcctc   2100

agatctttgg acctttccaa tgcgtctctt tctcctgtta ttgctgcaat gtattttctt   2160

gcttatatta aagttgtttc atcagtaaaa aaaaaaaaaa aaaaaaaaaa              2210


<210>  76
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Met Arg Arg Glu Asp Glu Glu Glu Glu Gly Thr Met Met Lys Ala 
1               5                   10                  15      


Lys Gly Asp Leu Glu Met Lys Glu Glu Glu Glu Ile Ser Glu Thr Gly 
            20                  25                  30          


Glu Leu Val Gly Pro Phe Val Ser Ala Met Pro Thr Pro Met Pro His 
        35                  40                  45              


Asn Lys Gly Thr Arg Phe Ser Glu Ala Trp Glu Tyr Phe His Leu Ala 
    50                  55                  60                  


Pro Ala Arg Ala Gly His His Pro Asn Gln Tyr Ala Thr Cys Arg Leu 
65                  70                  75                  80  


Cys Gly Arg Gln Val Ser Arg Gly Pro Gly Val Asn Val Gly Thr Thr 
                85                  90                  95      


Ala Leu Trp Lys His Leu Lys Ser Met His Arg Glu Glu Leu Glu Lys 
            100                 105                 110         


Ser Gly His Gly Gln Ala Gly Gln Arg Gln Asp Pro Arg Pro His Gly 
        115                 120                 125             


Pro Gln Leu Pro Thr Gly Ile Glu Gly Asn Trp Gly Arg Leu Leu Glu 
    130                 135                 140                 


Gln Val Gly Thr Met Ala Leu Trp Ala Ser Gln Arg Glu Lys Glu Val 
145                 150                 155                 160 


Leu Arg Arg Glu Arg Ala Val Glu Trp Arg Glu Arg Ala Val Glu Lys 
                165                 170                 175     


Arg Glu Arg Ala Leu Glu Glu Val Glu Arg Ala Ile Leu Glu Met Lys 
            180                 185                 190         


Trp Lys Val Arg Ala Glu Lys Glu Ala Cys Gln Arg Glu Lys Glu Leu 
        195                 200                 205             


Pro Ala Ala Val His Pro Phe His Phe Val 
    210                 215             


<210>  77
<211>  985
<212>  DNA
<213>  Homo sapiens

<400>  77
caaaccatgg gaggctcctc tcctagaccc tgcatcctga aagctgcgta cctgagagcc     60

tgcggtctgg ctgcagggac acacccaagg ggaggagctg caatcgtgtc tggggcccca    120

gcccaggctg gccggagctc ctgtttcccg ctgctctgct gcctgcccgg ggtaccaaca    180

tggcccagaa gcgtcctgcc tgcaccctga agcctgagtg tgtccagcag ctgctggttt    240

gctcccagga ggccaagaag tcagcctact gcccctacag tcactttcct gtgggggctg    300

ccctgctcac ccaggagggg agaatcttca aagggtgcaa catagaaaat gcctgctacc    360

cgctgggcat ctgtgctgaa cggaccgcta tccagaaggc cgtctcagaa gggtacaagg    420

atttcagggc aattgctatc gccagtgaca tgcaagatga ttttatctct ccatgtgggg    480

cctgcaggca agtcatgaga gagtttggca ccaactggcc cgtgtacatg accaagccgg    540

atggtacgta tattgtcatg acggtccagg agctgctgcc ctcctccttt gggcctgagg    600

acctgcagaa gacccagtga cagccagaga atgcccactg cctgtaacag ccacctggag    660

aacttcataa agatgtctca cagccctggg gacacctgcc cagtgggccc cagccctaca    720

gggactgggc aaagatgatg tttccagatt acactccagc ctgagtcagc acccctccta    780

gcaacctgcc ttgggactta gaacaccgcc gccccctgcc ccacctttcc tttccttcct    840

gtgggccctc tttcaaagtc cagcctagtc tggactgctt ccccatcagc cttcccaagg    900

ttctatcctg ttccgagcaa cttttctaat tataaacatc acagaacatc ctggatcaaa    960

aaaaaaaaaa aaaaaaaaaa aaaaa                                          985


<210>  78
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Gln Lys Arg Pro Ala Cys Thr Leu Lys Pro Glu Cys Val Gln 
1               5                   10                  15      


Gln Leu Leu Val Cys Ser Gln Glu Ala Lys Lys Ser Ala Tyr Cys Pro 
            20                  25                  30          


Tyr Ser His Phe Pro Val Gly Ala Ala Leu Leu Thr Gln Glu Gly Arg 
        35                  40                  45              


Ile Phe Lys Gly Cys Asn Ile Glu Asn Ala Cys Tyr Pro Leu Gly Ile 
    50                  55                  60                  


Cys Ala Glu Arg Thr Ala Ile Gln Lys Ala Val Ser Glu Gly Tyr Lys 
65                  70                  75                  80  


Asp Phe Arg Ala Ile Ala Ile Ala Ser Asp Met Gln Asp Asp Phe Ile 
                85                  90                  95      


Ser Pro Cys Gly Ala Cys Arg Gln Val Met Arg Glu Phe Gly Thr Asn 
            100                 105                 110         


Trp Pro Val Tyr Met Thr Lys Pro Asp Gly Thr Tyr Ile Val Met Thr 
        115                 120                 125             


Val Gln Glu Leu Leu Pro Ser Ser Phe Gly Pro Glu Asp Leu Gln Lys 
    130                 135                 140                 


Thr Gln 
145     


<210>  79
<211>  1551
<212>  DNA
<213>  Homo sapiens

<400>  79
ggcgcccaag ccgccgccgc cagatcggtg ccgattcctg ccctgccccg accgccagcg     60

cgaccatgtc ccatcactgg gggtacggca aacacaacgg acctgagcac tggcataagg    120

acttccccat tgccaaggga gagcgccagt cccctgttga catcgacact catacagcca    180

agtatgaccc ttccctgaag cccctgtctg tttcctatga tcaagcaact tccctgagga    240

tcctcaacaa tggtcatgct ttcaacgtgg agtttgatga ctctcaggac aaagcagtgc    300

tcaagggagg acccctggat ggcacttaca gattgattca gtttcacttt cactggggtt    360

cacttgatgg acaaggttca gagcatactg tggataaaaa gaaatatgct gcagaacttc    420

acttggttca ctggaacacc aaatatgggg attttgggaa agctgtgcag caacctgatg    480

gactggccgt tctaggtatt tttttgaagg ttggcagcgc taaaccgggc cttcagaaag    540

ttgttgatgt gctggattcc attaaaacaa agggcaagag tgctgacttc actaacttcg    600

atcctcgtgg cctccttcct gaatccctgg attactggac ctacccaggc tcactgacca    660

cccctcctct tctggaatgt gtgacctgga ttgtgctcaa ggaacccatc agcgtcagca    720

gcgagcaggt gttgaaattc cgtaaactta acttcaatgg ggagggtgaa cccgaagaac    780

tgatggtgga caactggcgc ccagctcagc cactgaagaa caggcaaatc aaagcttcct    840

tcaaataaga tggtcccata gtctgtatcc aaataatgaa tcttcgggtg tttcccttta    900

gctaagcaca gatctacctt ggtgatttgg accctggttg ctttgtgtct agttttctag    960

acccttcatc tcttacttga tagacttact aataaaatgt gaagactaga ccaattgtca   1020

tgcttgacac aactgctgtg gctggttggt gctttgttta tggtagtagt ttttctgtaa   1080

cacagaatat aggataagaa ataagaataa agtaccttga ctttgttcac agcatgtagg   1140

gtgatgagca ctcacaattg ttgactaaaa tgctgctttt aaaacatagg aaagtagaat   1200

ggttgagtgc aaatccatag cacaagataa attgagctag ttaaggcaaa tcaggtaaaa   1260

tagtcatgat tctatgtaat gtaaaccaga aaaaataaat gttcatgatt tcaagatgtt   1320

atattaaaga aaaactttaa aaattattat atatttatag caaagttatc ttaaatatga   1380

attctgttgt aatttaatga cttttgaatt acagagatat aaatgaagta ttatctgtaa   1440

aaattgttat aattagagtt gtgatacaga gtatatttcc attcagacaa tatatcataa   1500

cttaataaat attgtatttt agatatattc tctaataaaa ttcagaattc t            1551


<210>  80
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210>  81
<211>  1714
<212>  DNA
<213>  Homo sapiens

<400>  81
ggggcatttt gtgcctgcct agctatccag acagagcagc taccctcagc tctagctgat     60

actacagaca gtacaacaga tcaagaagta tggcagtgac aactcgtttg acacggttgc    120

acgaaaagat cctgcaaaat cattttggag ggaagcggct tagccttctc tataagggta    180

gtgtccatgg attccgtaat ggagttttgc ttgacagatg ttgtaatcaa gggcctactc    240

taacagtgat ttatagtgaa gatcatatta ttggagcata tgcggaagag agttaccagg    300

aaggaaagta tgcttccatc atcctttttg cacttcaaga tactaaaatt tcagaatgga    360

aactaggact atgtacacca gaaacactgt tttgttgtga tgttacaaaa tataactccc    420

caactaattt ccagatagat ggaagaaata gaaaagtgat tatggactta aagacaatgg    480

aaaatcttgg acttgctcaa aattgtacta tctctattca ggattatgaa gtttttcgat    540

gcgaagattc actggatgaa agaaagataa aaggggtcat tgagctcagg aagagcttac    600

tgtctgcctt gagaacttat gaaccatatg gatccctggt tcaacaaata cgaattctgc    660

tgctgggtcc aattggagct gggaagtcca gctttttcaa ctcagtgagg tctgttttcc    720

aagggcatgt aacgcatcag gctttggtgg gcactaatac aactgggata tctgagaagt    780

ataggacata ctctattaga gacgggaaag atggcaaata cctgccgttt attctgtgtg    840

actcactggg gctgagtgag aaagaaggcg gcctgtgcag ggatgacata ttctatatct    900

tgaacggtaa cattcgtgat agataccagt ttaatcccat ggaatcaatc aaattaaatc    960

atcatgacta cattgattcc ccatcgctga aggacagaat tcattgtgtg gcatttgtat   1020

ttgatgccag ctctattcaa tacttctcct ctcagatgat agtaaagatc aaaagaattc   1080

gaagggagtt ggtaaacgct ggtgtggtac atgtggcttt gctcactcat gtggatagca   1140

tggatttgat tacaaaaggt gaccttatag aaatagagag atgtgagcct gtgaggtcca   1200

agctagagga agtccaaaga aaacttggat ttgctctttc tgacatctcg gtggttagca   1260

attattcctc tgagtgggag ctggaccctg taaaggatgt tctaattctt tctgctctga   1320

gacgaatgct atgggctgca gatgacttct tagaggattt gccttttgag caaataggga   1380

atctaaggga ggaaattatc aactgtgcac aaggaaaaaa atagatatgt gaaaggttca   1440

cgtaaatttc ctcacatcac agaagattaa aattcagaaa ggagaaaaca cagaccaaag   1500

agaagtatct aagaccaaag ggatgtgttt tattaatgtc taggatgaag aaatgcatag   1560

aacattgtag tacttgtaaa taactagaaa taacatgatt tagtcataat tgtgaaaaat   1620

agtaataatt tttcttggat ttatgttctg tatctgtgaa aaaataaatt tcttataaaa   1680

ctcggaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                               1714


<210>  82
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ala Val Thr Thr Arg Leu Thr Arg Leu His Glu Lys Ile Leu Gln 
1               5                   10                  15      


Asn His Phe Gly Gly Lys Arg Leu Ser Leu Leu Tyr Lys Gly Ser Val 
            20                  25                  30          


His Gly Phe Arg Asn Gly Val Leu Leu Asp Arg Cys Cys Asn Gln Gly 
        35                  40                  45              


Pro Thr Leu Thr Val Ile Tyr Ser Glu Asp His Ile Ile Gly Ala Tyr 
    50                  55                  60                  


Ala Glu Glu Ser Tyr Gln Glu Gly Lys Tyr Ala Ser Ile Ile Leu Phe 
65                  70                  75                  80  


Ala Leu Gln Asp Thr Lys Ile Ser Glu Trp Lys Leu Gly Leu Cys Thr 
                85                  90                  95      


Pro Glu Thr Leu Phe Cys Cys Asp Val Thr Lys Tyr Asn Ser Pro Thr 
            100                 105                 110         


Asn Phe Gln Ile Asp Gly Arg Asn Arg Lys Val Ile Met Asp Leu Lys 
        115                 120                 125             


Thr Met Glu Asn Leu Gly Leu Ala Gln Asn Cys Thr Ile Ser Ile Gln 
    130                 135                 140                 


Asp Tyr Glu Val Phe Arg Cys Glu Asp Ser Leu Asp Glu Arg Lys Ile 
145                 150                 155                 160 


Lys Gly Val Ile Glu Leu Arg Lys Ser Leu Leu Ser Ala Leu Arg Thr 
                165                 170                 175     


Tyr Glu Pro Tyr Gly Ser Leu Val Gln Gln Ile Arg Ile Leu Leu Leu 
            180                 185                 190         


Gly Pro Ile Gly Ala Gly Lys Ser Ser Phe Phe Asn Ser Val Arg Ser 
        195                 200                 205             


Val Phe Gln Gly His Val Thr His Gln Ala Leu Val Gly Thr Asn Thr 
    210                 215                 220                 


Thr Gly Ile Ser Glu Lys Tyr Arg Thr Tyr Ser Ile Arg Asp Gly Lys 
225                 230                 235                 240 


Asp Gly Lys Tyr Leu Pro Phe Ile Leu Cys Asp Ser Leu Gly Leu Ser 
                245                 250                 255     


Glu Lys Glu Gly Gly Leu Cys Arg Asp Asp Ile Phe Tyr Ile Leu Asn 
            260                 265                 270         


Gly Asn Ile Arg Asp Arg Tyr Gln Phe Asn Pro Met Glu Ser Ile Lys 
        275                 280                 285             


Leu Asn His His Asp Tyr Ile Asp Ser Pro Ser Leu Lys Asp Arg Ile 
    290                 295                 300                 


His Cys Val Ala Phe Val Phe Asp Ala Ser Ser Ile Gln Tyr Phe Ser 
305                 310                 315                 320 


Ser Gln Met Ile Val Lys Ile Lys Arg Ile Arg Arg Glu Leu Val Asn 
                325                 330                 335     


Ala Gly Val Val His Val Ala Leu Leu Thr His Val Asp Ser Met Asp 
            340                 345                 350         


Leu Ile Thr Lys Gly Asp Leu Ile Glu Ile Glu Arg Cys Glu Pro Val 
        355                 360                 365             


Arg Ser Lys Leu Glu Glu Val Gln Arg Lys Leu Gly Phe Ala Leu Ser 
    370                 375                 380                 


Asp Ile Ser Val Val Ser Asn Tyr Ser Ser Glu Trp Glu Leu Asp Pro 
385                 390                 395                 400 


Val Lys Asp Val Leu Ile Leu Ser Ala Leu Arg Arg Met Leu Trp Ala 
                405                 410                 415     


Ala Asp Asp Phe Leu Glu Asp Leu Pro Phe Glu Gln Ile Gly Asn Leu 
            420                 425                 430         


Arg Glu Glu Ile Ile Asn Cys Ala Gln Gly Lys Lys 
        435                 440                 


<210>  83
<211>  2750
<212>  DNA
<213>  Homo sapiens

<400>  83
attgtttcct actccatttt ctctggggca atagcagaat aggagcaagc cagcactagt     60

cagctaacta agtgactcaa ccaaggcctt ttttccttgt tatctttgca gatacttcat    120

tttcttagcg tttctggaga ttacaacatc ctgcggttcc gtttctggga actttactga    180

tttatctccc ccctcacaca aataagcatt gattcctgca tttctgaaga tctcaagatc    240

tggactactg ttgaaaaaat ttccagtgag gctcacttat gtctgtaaag atgggaaaaa    300

aatacaagaa cattgttcta ctaaaaggat tagaggtcat caatgattat cattttagaa    360

tggttaagtc cttactgagc aacgatttaa aacttaattt aaaaatgaga gaagagtatg    420

acaaaattca gattgctgac ttgatggaag aaaagttccg aggtgatgct ggtttgggca    480

aactaataaa aattttcgaa gatataccaa cgcttgaaga cctggctgaa actcttaaaa    540

aagaaaagtt aaaagtaaaa ggaccagccc tatcaagaaa gaggaagaag gaagtggatg    600

ctacttcacc tgcaccctcc acaagcagca ctgtcaaaac tgaaggagca gaggcaactc    660

ctggagctca gaaaagaaaa aaatcaacca aagaaaaggc tggacccaaa gggagtaagg    720

tgtccgagga acagactcag cctccctctc ctgcaggagc cggcatgtcc acagccatgg    780

gccgttcccc atctcccaag acctcattgt cagctccacc caacagttct tcaactgaga    840

acccgaaaac agtggccaaa tgtcaggtaa ctcccagaag aaatgttctc caaaaacgcc    900

cagtgatagt gaaggtactg agtacaacaa agccatttga atatgagacc ccagaaatgg    960

agaaaaaaat aatgtttcat gctacagtgg ctacacagac acagttcttc catgtgaagg   1020

ttttaaacac cagcttgaag gagaaattca atggaaagaa aatcatcatc atatcagatt   1080

atttggaata tgatagtctc ctagaggtca atgaagaatc tactgtatct gaagctggtc   1140

ctaaccaaac gtttgaggtt ccaaataaaa tcatcaacag agcaaaggaa actctgaaga   1200

ttgatattct tcacaaacaa gcttcaggaa atattgtata tggggtattt atgctacata   1260

agaaaacagt aaatcagaag accacaatct acgaaattca ggatgataga ggaaaaatgg   1320

atgtagtggg gacaggacaa tgtcacaata tcccctgtga agaaggagat aagctccaac   1380

ttttctgctt tcgacttaga aaaaagaacc agatgtcaaa actgatttca gaaatgcata   1440

gttttatcca gataaagaaa aaaacaaacc cgagaaacaa tgaccccaag agcatgaagc   1500

taccccagga acagcgtcag cttccatatc cttcagaggc cagcacaacc ttccctgaga   1560

gccatcttcg gactcctcag atgccaccaa caactccatc cagcagtttc ttcaccaaga   1620

aaagtgaaga cacaatctcc aaaatgaatg acttcatgag gatgcagata ctgaaggaag   1680

ggagtcattt tccaggaccg ttcatgacca gcataggccc agctgagagc catccccaca   1740

ctcctcagat gcctccatca acaccaagca gcagtttctt aaccacgttg aaaccaagac   1800

tgaagactga acctgaagaa gtttccatag aagacagtgc ccagagtgac ctcaaagaag   1860

tgatggtgct gaacgcaaca gaatcatttg tatatgagcc caaagagcag aagaaaatgt   1920

ttcatgccac agtggcaact gagaatgaag tcttccgagt gaaggttttt aatattgacc   1980

taaaggagaa gttcacccca aagaagatca ttgccatagc aaattatgtt tgccgcaatg   2040

ggttcctgga ggtatatcct ttcacacttg tggctgatgt gaatgctgac cgaaacatgg   2100

agatcccaaa aggattgatt agaagtgcca gcgtaactcc taaaatcaat cagctttgct   2160

cacaaactaa aggaagtttt gtgaatgggg tgtttgaggt acataagaaa aatgtaaggg   2220

gtgaattcac ttattatgaa atacaagata atacagggaa gatggaagtg gtggtgcatg   2280

gacgactgac cacaatcaac tgtgaggaag gagataaact gaaactcacc tgctttgaat   2340

tggcaccgaa aagtgggaat accggggagt tgagatctgt aattcatagt cacatcaagg   2400

tcatcaagac caggaaaaac aagaaagaca tactcaatcc tgattcaagt atggaaactt   2460

caccagactt tttcttctaa aatctggatg tcattgacga taatgtttat ggagataagg   2520

tctaagtgcc taaaaaaatg tacatatacc tggttgaaat acaacactat acatacacac   2580

caccatatat actagctgtt aatcctatgg aatggggtat tgggagtgct tttttaattt   2640

ttcatagttt ttttttaata aaatggcata ttttgcatct acaacttcta taatttgaaa   2700

aaataaataa acattatctt ttttgtgaaa ggaaaaaaaa aaaaaaaaaa              2750


<210>  84
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp 
            20                  25                  30          


Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile 
        35                  40                  45              


Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu 
65                  70                  75                  80  


Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro Ala Leu Ser Arg 
                85                  90                  95      


Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala Pro Ser Thr Ser 
            100                 105                 110         


Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro Gly Ala Gln Lys 
        115                 120                 125             


Arg Lys Lys Ser Thr Lys Glu Lys Ala Gly Pro Lys Gly Ser Lys Val 
    130                 135                 140                 


Ser Glu Glu Gln Thr Gln Pro Pro Ser Pro Ala Gly Ala Gly Met Ser 
145                 150                 155                 160 


Thr Ala Met Gly Arg Ser Pro Ser Pro Lys Thr Ser Leu Ser Ala Pro 
                165                 170                 175     


Pro Asn Ser Ser Ser Thr Glu Asn Pro Lys Thr Val Ala Lys Cys Gln 
            180                 185                 190         


Val Thr Pro Arg Arg Asn Val Leu Gln Lys Arg Pro Val Ile Val Lys 
        195                 200                 205             


Val Leu Ser Thr Thr Lys Pro Phe Glu Tyr Glu Thr Pro Glu Met Glu 
    210                 215                 220                 


Lys Lys Ile Met Phe His Ala Thr Val Ala Thr Gln Thr Gln Phe Phe 
225                 230                 235                 240 


His Val Lys Val Leu Asn Thr Ser Leu Lys Glu Lys Phe Asn Gly Lys 
                245                 250                 255     


Lys Ile Ile Ile Ile Ser Asp Tyr Leu Glu Tyr Asp Ser Leu Leu Glu 
            260                 265                 270         


Val Asn Glu Glu Ser Thr Val Ser Glu Ala Gly Pro Asn Gln Thr Phe 
        275                 280                 285             


Glu Val Pro Asn Lys Ile Ile Asn Arg Ala Lys Glu Thr Leu Lys Ile 
    290                 295                 300                 


Asp Ile Leu His Lys Gln Ala Ser Gly Asn Ile Val Tyr Gly Val Phe 
305                 310                 315                 320 


Met Leu His Lys Lys Thr Val Asn Gln Lys Thr Thr Ile Tyr Glu Ile 
                325                 330                 335     


Gln Asp Asp Arg Gly Lys Met Asp Val Val Gly Thr Gly Gln Cys His 
            340                 345                 350         


Asn Ile Pro Cys Glu Glu Gly Asp Lys Leu Gln Leu Phe Cys Phe Arg 
        355                 360                 365             


Leu Arg Lys Lys Asn Gln Met Ser Lys Leu Ile Ser Glu Met His Ser 
    370                 375                 380                 


Phe Ile Gln Ile Lys Lys Lys Thr Asn Pro Arg Asn Asn Asp Pro Lys 
385                 390                 395                 400 


Ser Met Lys Leu Pro Gln Glu Gln Arg Gln Leu Pro Tyr Pro Ser Glu 
                405                 410                 415     


Ala Ser Thr Thr Phe Pro Glu Ser His Leu Arg Thr Pro Gln Met Pro 
            420                 425                 430         


Pro Thr Thr Pro Ser Ser Ser Phe Phe Thr Lys Lys Ser Glu Asp Thr 
        435                 440                 445             


Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly 
    450                 455                 460                 


Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser 
465                 470                 475                 480 


His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe 
                485                 490                 495     


Leu Thr Thr Leu Lys Pro Arg Leu Lys Thr Glu Pro Glu Glu Val Ser 
            500                 505                 510         


Ile Glu Asp Ser Ala Gln Ser Asp Leu Lys Glu Val Met Val Leu Asn 
        515                 520                 525             


Ala Thr Glu Ser Phe Val Tyr Glu Pro Lys Glu Gln Lys Lys Met Phe 
    530                 535                 540                 


His Ala Thr Val Ala Thr Glu Asn Glu Val Phe Arg Val Lys Val Phe 
545                 550                 555                 560 


Asn Ile Asp Leu Lys Glu Lys Phe Thr Pro Lys Lys Ile Ile Ala Ile 
                565                 570                 575     


Ala Asn Tyr Val Cys Arg Asn Gly Phe Leu Glu Val Tyr Pro Phe Thr 
            580                 585                 590         


Leu Val Ala Asp Val Asn Ala Asp Arg Asn Met Glu Ile Pro Lys Gly 
        595                 600                 605             


Leu Ile Arg Ser Ala Ser Val Thr Pro Lys Ile Asn Gln Leu Cys Ser 
    610                 615                 620                 


Gln Thr Lys Gly Ser Phe Val Asn Gly Val Phe Glu Val His Lys Lys 
625                 630                 635                 640 


Asn Val Arg Gly Glu Phe Thr Tyr Tyr Glu Ile Gln Asp Asn Thr Gly 
                645                 650                 655     


Lys Met Glu Val Val Val His Gly Arg Leu Thr Thr Ile Asn Cys Glu 
            660                 665                 670         


Glu Gly Asp Lys Leu Lys Leu Thr Cys Phe Glu Leu Ala Pro Lys Ser 
        675                 680                 685             


Gly Asn Thr Gly Glu Leu Arg Ser Val Ile His Ser His Ile Lys Val 
    690                 695                 700                 


Ile Lys Thr Arg Lys Asn Lys Lys Asp Ile Leu Asn Pro Asp Ser Ser 
705                 710                 715                 720 


Met Glu Thr Ser Pro Asp Phe Phe Phe 
                725                 


<210>  85
<211>  2787
<212>  DNA
<213>  Homo sapiens

<400>  85
agagcggagg ccgcactcca gcactgcgca gggaccgcct tggaccgcag ttgccggcca     60

ggaatcccag tgtcacggtg gacacgcctc cctcgcgccc ttgccgccca cctgctcacc    120

cagctcaggg gctttggaat tctgtggcca cactgcgagg agatcggttc tgggtcggag    180

gctacaggaa gactcccact ccctgaaatc tggagtgaag aacgccgcca tccagccacc    240

attccaagga ggtgcaggag aacagctctg tgataccatt taacttgttg acattacttt    300

tatttgaagg aacgtatatt agagcttact ttgcaaagaa ggaagatggt tgtttccgaa    360

gtggacatcg caaaagctga tccagctgct gcatcccacc ctctattact gaatggagat    420

gctactgtgg cccagaaaaa tccaggctcg gtggctgaga acaacctgtg cagccagtat    480

gaggagaagg tgcgcccctg catcgacctc attgactccc tgcgggctct aggtgtggag    540

caggacctgg ccctgccagc catcgccgtc atcggggacc agagctcggg caagagctcc    600

gtgttggagg cactgtcagg agttgccctt cccagaggca gcgggatcgt gaccagatgc    660

ccgctggtgc tgaaactgaa gaaacttgtg aacgaagata agtggagagg caaggtcagt    720

taccaggact acgagattga gatttcggat gcttcagagg tagaaaagga aattaataaa    780

gcccagaatg ccatcgccgg ggaaggaatg ggaatcagtc atgagctaat caccctggag    840

atcagctccc gagatgtccc ggatctgact ctaatagacc ttcctggcat aaccagagtg    900

gctgtgggca atcagcctgc tgacattggg tataagatca agacactcat caagaagtac    960

atccagaggc aggagacaat cagcctggtg gtggtcccca gtaatgtgga catcgccacc   1020

acagaggctc tcagcatggc ccaggaggtg gaccccgagg gagacaggac catcggaatc   1080

ttgacgaagc ctgatctggt ggacaaagga actgaagaca aggttgtgga cgtggtgcgg   1140

aacctcgtgt tccacctgaa gaagggttac atgattgtca agtgccgggg ccagcaggag   1200

atccaggacc agctgagcct gtccgaagcc ctgcagagag agaagatctt ctttgagaac   1260

cacccatatt tcagggatct gctggaggaa ggaaaggcca cggttccctg cctggcagaa   1320

aaacttacca gcgagctcat cacacatatc tgtaaatctc tgcccctgtt agaaaatcaa   1380

atcaaggaga ctcaccagag aataacagag gagctacaaa agtatggtgt cgacataccg   1440

gaagacgaaa atgaaaaaat gttcttcctg atagataaaa ttaatgcctt taatcaggac   1500

atcactgctc tcatgcaagg agaggaaact gtaggggagg aagacattcg gctgtttacc   1560

agactccgac acgagttcca caaatggagt acaataattg aaaacaattt tcaagaaggc   1620

cataaaattt tgagtagaaa aatccagaaa tttgaaaatc agtatcgtgg tagagagctg   1680

ccaggctttg tgaattacag gacatttgag acaatcgtga aacagcaaat caaggcactg   1740

gaagagccgg ctgtggatat gctacacacc gtgacggata tggtccggct tgctttcaca   1800

gatgtttcga taaaaaattt tgaagagttt tttaacctcc acagaaccgc caagtccaaa   1860

attgaagaca ttagagcaga acaagagaga gaaggtgaga agctgatccg cctccacttc   1920

cagatggaac agattgtcta ctgccaggac caggtataca ggggtgcatt gcagaaggtc   1980

agagagaagg agctggaaga agaaaagaag aagaaatcct gggattttgg ggctttccag   2040

tccagctcgg caacagactc ttccatggag gagatctttc agcacctgat ggcctatcac   2100

caggaggcca gcaagcgcat ctccagccac atccctttga tcatccagtt cttcatgctc   2160

cagacgtacg gccagcagct tcagaaggcc atgctgcagc tcctgcagga caaggacacc   2220

tacagctggc tcctgaagga gcggagcgac accagcgaca agcggaagtt cctgaaggag   2280

cggcttgcac ggctgacgca ggctcggcgc cggcttgccc agttccccgg ttaaccacac   2340

tctgtccagc cccgtagacg tgcacgcaca ctgtctgccc ccgttcccgg gtagccactg   2400

gactgacgac ttgagtgctc agtagtcaga ctggatagtc cgtctctgct tatccgttag   2460

ccgtggtgat ttagcaggaa gctgtgagag cagtttggtt tctagcatga agacagagcc   2520

ccaccctcag atgcacatga gctggcggga ttgaaggatg ctgtcttcgt actgggaaag   2580

ggattttcag ccctcagaat cgctccacct tgcagctctc cccttctctg tattcctaga   2640

aactgacaca tgctgaacat cacagcttat ttcctcattt ttataatgtc ccttcacaaa   2700

cccagtgttt taggagcatg agtgccgtgt gtgtgcgtcc tgtcggagcc ctgtctcctc   2760

tctctgtaat aaactcattt ctagcag                                       2787


<210>  86
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Val Val Ser Glu Val Asp Ile Ala Lys Ala Asp Pro Ala Ala Ala 
1               5                   10                  15      


Ser His Pro Leu Leu Leu Asn Gly Asp Ala Thr Val Ala Gln Lys Asn 
            20                  25                  30          


Pro Gly Ser Val Ala Glu Asn Asn Leu Cys Ser Gln Tyr Glu Glu Lys 
        35                  40                  45              


Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val 
    50                  55                  60                  


Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser 
65                  70                  75                  80  


Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro 
                85                  90                  95      


Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys 
            100                 105                 110         


Lys Leu Val Asn Glu Asp Lys Trp Arg Gly Lys Val Ser Tyr Gln Asp 
        115                 120                 125             


Tyr Glu Ile Glu Ile Ser Asp Ala Ser Glu Val Glu Lys Glu Ile Asn 
    130                 135                 140                 


Lys Ala Gln Asn Ala Ile Ala Gly Glu Gly Met Gly Ile Ser His Glu 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Ile Ser Ser Arg Asp Val Pro Asp Leu Thr Leu 
                165                 170                 175     


Ile Asp Leu Pro Gly Ile Thr Arg Val Ala Val Gly Asn Gln Pro Ala 
            180                 185                 190         


Asp Ile Gly Tyr Lys Ile Lys Thr Leu Ile Lys Lys Tyr Ile Gln Arg 
        195                 200                 205             


Gln Glu Thr Ile Ser Leu Val Val Val Pro Ser Asn Val Asp Ile Ala 
    210                 215                 220                 


Thr Thr Glu Ala Leu Ser Met Ala Gln Glu Val Asp Pro Glu Gly Asp 
225                 230                 235                 240 


Arg Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Val Asp Lys Gly Thr 
                245                 250                 255     


Glu Asp Lys Val Val Asp Val Val Arg Asn Leu Val Phe His Leu Lys 
            260                 265                 270         


Lys Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Gln Asp 
        275                 280                 285             


Gln Leu Ser Leu Ser Glu Ala Leu Gln Arg Glu Lys Ile Phe Phe Glu 
    290                 295                 300                 


Asn His Pro Tyr Phe Arg Asp Leu Leu Glu Glu Gly Lys Ala Thr Val 
305                 310                 315                 320 


Pro Cys Leu Ala Glu Lys Leu Thr Ser Glu Leu Ile Thr His Ile Cys 
                325                 330                 335     


Lys Ser Leu Pro Leu Leu Glu Asn Gln Ile Lys Glu Thr His Gln Arg 
            340                 345                 350         


Ile Thr Glu Glu Leu Gln Lys Tyr Gly Val Asp Ile Pro Glu Asp Glu 
        355                 360                 365             


Asn Glu Lys Met Phe Phe Leu Ile Asp Lys Ile Asn Ala Phe Asn Gln 
    370                 375                 380                 


Asp Ile Thr Ala Leu Met Gln Gly Glu Glu Thr Val Gly Glu Glu Asp 
385                 390                 395                 400 


Ile Arg Leu Phe Thr Arg Leu Arg His Glu Phe His Lys Trp Ser Thr 
                405                 410                 415     


Ile Ile Glu Asn Asn Phe Gln Glu Gly His Lys Ile Leu Ser Arg Lys 
            420                 425                 430         


Ile Gln Lys Phe Glu Asn Gln Tyr Arg Gly Arg Glu Leu Pro Gly Phe 
        435                 440                 445             


Val Asn Tyr Arg Thr Phe Glu Thr Ile Val Lys Gln Gln Ile Lys Ala 
    450                 455                 460                 


Leu Glu Glu Pro Ala Val Asp Met Leu His Thr Val Thr Asp Met Val 
465                 470                 475                 480 


Arg Leu Ala Phe Thr Asp Val Ser Ile Lys Asn Phe Glu Glu Phe Phe 
                485                 490                 495     


Asn Leu His Arg Thr Ala Lys Ser Lys Ile Glu Asp Ile Arg Ala Glu 
            500                 505                 510         


Gln Glu Arg Glu Gly Glu Lys Leu Ile Arg Leu His Phe Gln Met Glu 
        515                 520                 525             


Gln Ile Val Tyr Cys Gln Asp Gln Val Tyr Arg Gly Ala Leu Gln Lys 
    530                 535                 540                 


Val Arg Glu Lys Glu Leu Glu Glu Glu Lys Lys Lys Lys Ser Trp Asp 
545                 550                 555                 560 


Phe Gly Ala Phe Gln Ser Ser Ser Ala Thr Asp Ser Ser Met Glu Glu 
                565                 570                 575     


Ile Phe Gln His Leu Met Ala Tyr His Gln Glu Ala Ser Lys Arg Ile 
            580                 585                 590         


Ser Ser His Ile Pro Leu Ile Ile Gln Phe Phe Met Leu Gln Thr Tyr 
        595                 600                 605             


Gly Gln Gln Leu Gln Lys Ala Met Leu Gln Leu Leu Gln Asp Lys Asp 
    610                 615                 620                 


Thr Tyr Ser Trp Leu Leu Lys Glu Arg Ser Asp Thr Ser Asp Lys Arg 
625                 630                 635                 640 


Lys Phe Leu Lys Glu Arg Leu Ala Arg Leu Thr Gln Ala Arg Arg Arg 
                645                 650                 655     


Leu Ala Gln Phe Pro Gly 
            660         


<210>  87
<211>  2101
<212>  DNA
<213>  Homo sapiens

<400>  87
agttcgtaaa ggagccgggt gacttcagag gcgccggccc gtccgtctgc cgcacctgag     60

cacggcccct gcccgagcct ggcccgccgc gatgctgtag ggaccgccgt gtcctcccgc    120

cggaccgtta tccgcgccgg gcgcccgcca gacccgctgg caagatgccg cgctccttcc    180

tggtcaagaa gcatttcaac gcctccaaaa agccaaacta cagcgaactg gacacacata    240

cagtgattat ttccccgtat ctctatgaga gttactccat gcctgtcata ccacaaccag    300

agatcctcag ctcaggagca tacagcccca tcactgtgtg gactaccgct gctccattcc    360

acgcccagct acccaatggc ctctctcctc tttccggata ctcctcatct ttggggcgag    420

tgagtccccc tcctccatct gacacctcct ccaaggacca cagtggctca gaaagcccca    480

ttagtgatga agaggaaaga ctacagtcca agctttcaga cccccatgcc attgaagctg    540

aaaagtttca gtgcaattta tgcaataaga cctattcaac tttttctggg ctggccaaac    600

ataagcagct gcactgcgat gcccagtcta gaaaatcttt cagctgtaaa tactgtgaca    660

aggaatatgt gagcctgggc gccctgaaga tgcatattcg gacccacaca ttaccttgtg    720

tttgcaagat ctgcggcaag gcgttttcca gaccctggtt gcttcaagga cacattagaa    780

ctcacacggg ggagaagcct ttttcttgcc ctcactgcaa cagagcattt gcagacaggt    840

caaatctgag ggctcatctg cagacccatt ctgatgtaaa gaaataccag tgcaaaaact    900

gctccaaaac cttctccaga atgtctctcc tgcacaaaca tgaggaatct ggctgctgtg    960

tagcacactg agtgacgcaa tcaatgttta ctcgaacaga atgcatttct tcactccgaa   1020

gccaaatgac aaataaagtc caaaggcatt ttctcctgtg ctgaccaacc aaataatatg   1080

tatagacaca cacacatatg cacacacaca cacacacacc cacagagaga gagctgcaag   1140

agcatggaat tcatgtgttt aaagataatc ctttccatgt gaagtttaaa attactatat   1200

atttgctgat ggctagattg agagaataaa agacagtaac ctttctcttc aaagataaaa   1260

tgaaaagcac attgcatctt ttcttcctaa aaaaatgcaa agatttacat tgctgccaaa   1320

tcatttcaac tgaaaagaac agtattgctt tgtaatagag tctgtaatag gatttcccat   1380

aggaagagat ctgccagacg cgaactcagg tgccttaaaa agtattccaa gtttactcca   1440

ttacatgtcg gttgtctggt tgccattgtt gaactaaagc ctttttttga ttacctgtag   1500

tgctttaaag tatattttta aaagggagga aaaaaataac aagaacaaaa cacaggagaa   1560

tgtattaaaa gtatttttgt tttgttttgt ttttgccaat taacagtatg tgccttgggg   1620

gaggagggaa agattagctt tgaacattcc tggcgcatgc tccattgtct tactatttta   1680

aaacatttta ataatttttg aaaattaatt aaagatggga ataagtgcaa aagaggattc   1740

ttacaaattc attaatgtac ttaaactatt tcaaatgcat accacaaatg caataataca   1800

ataccccttc caagtgcctt tttaaattgt atagttgatg agtcaatgta aatttgtgtt   1860

tatttttata tgattgaatg agttctgtat gaaactgaga tgttgtctat agctatgtct   1920

ataaacaacc tgaagacttg tgaaatcaat gtttcttttt taaaaaacaa ttttcaagtt   1980

ttttttacaa taaacagttt tgatttaaaa tctcgtttgt atactatttt cagagacttt   2040

acttgcttca tgattagtac caaaccactg tacaaagaat tgtttgttaa caagaaaaaa   2100

a                                                                   2101


<210>  88
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Pro Arg Ser Phe Leu Val Lys Lys His Phe Asn Ala Ser Lys Lys 
1               5                   10                  15      


Pro Asn Tyr Ser Glu Leu Asp Thr His Thr Val Ile Ile Ser Pro Tyr 
            20                  25                  30          


Leu Tyr Glu Ser Tyr Ser Met Pro Val Ile Pro Gln Pro Glu Ile Leu 
        35                  40                  45              


Ser Ser Gly Ala Tyr Ser Pro Ile Thr Val Trp Thr Thr Ala Ala Pro 
    50                  55                  60                  


Phe His Ala Gln Leu Pro Asn Gly Leu Ser Pro Leu Ser Gly Tyr Ser 
65                  70                  75                  80  


Ser Ser Leu Gly Arg Val Ser Pro Pro Pro Pro Ser Asp Thr Ser Ser 
                85                  90                  95      


Lys Asp His Ser Gly Ser Glu Ser Pro Ile Ser Asp Glu Glu Glu Arg 
            100                 105                 110         


Leu Gln Ser Lys Leu Ser Asp Pro His Ala Ile Glu Ala Glu Lys Phe 
        115                 120                 125             


Gln Cys Asn Leu Cys Asn Lys Thr Tyr Ser Thr Phe Ser Gly Leu Ala 
    130                 135                 140                 


Lys His Lys Gln Leu His Cys Asp Ala Gln Ser Arg Lys Ser Phe Ser 
145                 150                 155                 160 


Cys Lys Tyr Cys Asp Lys Glu Tyr Val Ser Leu Gly Ala Leu Lys Met 
                165                 170                 175     


His Ile Arg Thr His Thr Leu Pro Cys Val Cys Lys Ile Cys Gly Lys 
            180                 185                 190         


Ala Phe Ser Arg Pro Trp Leu Leu Gln Gly His Ile Arg Thr His Thr 
        195                 200                 205             


Gly Glu Lys Pro Phe Ser Cys Pro His Cys Asn Arg Ala Phe Ala Asp 
    210                 215                 220                 


Arg Ser Asn Leu Arg Ala His Leu Gln Thr His Ser Asp Val Lys Lys 
225                 230                 235                 240 


Tyr Gln Cys Lys Asn Cys Ser Lys Thr Phe Ser Arg Met Ser Leu Leu 
                245                 250                 255     


His Lys His Glu Glu Ser Gly Cys Cys Val Ala His 
            260                 265             


<210>  89
<211>  2704
<212>  DNA
<213>  Homo sapiens

<400>  89
gggagaaacg ttctcactcg ctctctgctc gctgcgggcg ctccccgccc tctgctgcca     60

gaaccttggg gatgtgccta gacccggcgc agcacacgtc cgggccaacc gcgagcagaa    120

caaacctttg gcgggcggcc aggaggctcc ctcccagcca ccgcccccct ccagcgcctt    180

tttttccccc catacaatac aagatcttcc ttcctcagtt cccttaaagc acagcccagg    240

gaaacctcct cacagttttc atccagccac gggccagcat gtctgggggc aaatacgtag    300

actcggaggg acatctctac accgttccca tccgggaaca gggcaacatc tacaagccca    360

acaacaaggc catggcagac gagctgagcg agaagcaagt gtacgacgcg cacaccaagg    420

agatcgacct ggtcaaccgc gaccctaaac acctcaacga tgacgtggtc aagattgact    480

ttgaagatgt gattgcagaa ccagaaggga cacacagttt tgacggcatt tggaaggcca    540

gcttcaccac cttcactgtg acgaaatact ggttttaccg cttgctgtct gccctctttg    600

gcatcccgat ggcactcatc tggggcattt acttcgccat tctctctttc ctgcacatct    660

gggcagttgt accatgcatt aagagcttcc tgattgagat tcagtgcatc agccgtgtct    720

attccatcta cgtccacacc gtctgtgacc cactctttga agctgttggg aaaatattca    780

gcaatgtccg catcaacttg cagaaagaaa tataaatgac atttcaagga tagaagtata    840

cctgattttt tttcctttta attttcctgg tgccaatttc aagttccaag ttgctaatac    900

agcaacaatt tatgaattga attatcttgg ttgaaaataa aaagatcact ttctcagttt    960

tcataagtat tatgtctctt ctgagctatt tcatctattt ttggcagtct gaatttttaa   1020

aacccattta aatttttttc cttacctttt tatttgcatg tggatcaacc atcgctttat   1080

tggctgagat atgaacatat tgttgaaagg taatttgaga gaaatatgaa gaactgagga   1140

ggaaaaaaaa aaaaaagaaa agaaccaaca acctcaactg cctactccaa aatgttggtc   1200

attttatgtt aagggaagaa ttccagggta tggccatgga gtgtacaagt atgtgggcag   1260

attttcagca aactcttttc ccactgttta aggagttagt ggattactgc cattcacttc   1320

ataatccagt aggatccagt gatccttaca agttagaaaa cataatcttc tgccttctca   1380

tgatccaact aatgccttac tcttcttgaa attttaacct atgatatttt ctgtgcctga   1440

atatttgtta tgtagataac aagacctcag tgccttcctg tttttcacat tttccttttc   1500

aaatagggtc taactcagca actcgcttta ggtcagcagc ctccctgaag accaaaatta   1560

gaatatccat gacctagttt tccatgcgtg tttctgactc tgagctacag agtctggtga   1620

agctcacttc tgggcttcat ctggcaacat ctttatccgt agtgggtatg gttgacacta   1680

gcccaatgaa atgaattaaa gtggaccaat agggctgagc tctctgtggg ctggcagtcc   1740

tggaagccag ctttccctgc ctctcatcaa ctgaatgagg tcagcatgtc tattcagctt   1800

cgtttatttt caagaataat cacgctttcc tgaatccaaa ctaatccatc accggggtgg   1860

tttagtggct caacattgtg ttcccatttc agctgatcag tgggcctcca aggaggggct   1920

gtaaaatgga ggccattgtg tgagcctatc agagttgctg caaacctgac ccctgctcag   1980

taaagcactt gcaaccgtct gttatgctgt gacacatggc ccctccccct gccaggagct   2040

ttggacctaa tccaagcatc cctttgccca gaaagaagat gggggaggag gcagtaataa   2100

aaagattgaa gtattttgct ggaataagtt caaattcttc tgaactcaaa ctgaggaatt   2160

tcacctgtaa acctgagtcg tacagaaagc tgcctggtat atccaaaagc tttttattcc   2220

tcctgctcat attgtgattc tgcctttggg gacttttctt aaaccttcag ttatgatttt   2280

tttttcatac acttattgga actctgcttg atttttgcct cttccagtct tcctgacact   2340

ttaattacca acctgttacc tactttgact ttttgcattt aaaacagaca ctggcatgga   2400

tatagtttta cttttaaact gtgtacataa ctgaaaatgt gctatactgc atacttttta   2460

aatgtaaaga tatttttatc tttatatgaa gaaaatcact taggaaatgg ctttgtgatt   2520

caatctgtaa actgtgtatt ccaagacatg tctgttctac atagatgctt agtccctcat   2580

gcaaatcaat tactggtcca aaagattgct gaaattttat atgcttactg atatatttta   2640

caatttttta tcatgcatgt cctgtaaagg ttacaagcct gcacaataaa aatgtttaac   2700

ggtt                                                                2704


<210>  90
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ser Gly Gly Lys Tyr Val Asp Ser Glu Gly His Leu Tyr Thr Val 
1               5                   10                  15      


Pro Ile Arg Glu Gln Gly Asn Ile Tyr Lys Pro Asn Asn Lys Ala Met 
            20                  25                  30          


Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Thr Lys Glu 
        35                  40                  45              


Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val Val 
    50                  55                  60                  


Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Thr His Ser 
65                  70                  75                  80  


Phe Asp Gly Ile Trp Lys Ala Ser Phe Thr Thr Phe Thr Val Thr Lys 
                85                  90                  95      


Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met Ala 
            100                 105                 110         


Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile Trp 
        115                 120                 125             


Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys Ile 
    130                 135                 140                 


Ser Arg Val Tyr Ser Ile Tyr Val His Thr Val Cys Asp Pro Leu Phe 
145                 150                 155                 160 


Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln Lys 
                165                 170                 175     


Glu Ile 
        


<210>  91
<211>  1110
<212>  DNA
<213>  Homo sapiens

<400>  91
gacagagccc gggccacgga gctccttgcc agctctcctc ctcgcacagc cgctcgaacc     60

gcctgctgag ccccatggcc cgcgccacgc tctccgccgc ccccagcaat ccccggctcc    120

tgcgggtggc gctgctgctc ctgctcctgg tggccgccag ccggcgcgca gcaggagcgc    180

ccctggccac tgaactgcgc tgccagtgct tgcagaccct gcagggaatt cacctcaaga    240

acatccaaag tgtgaaggtg aagtcccccg gaccccactg cgcccaaacc gaagtcatag    300

ccacactcaa gaatgggcag aaagcttgtc tcaaccccgc atcgcccatg gttaagaaaa    360

tcatcgaaaa gatgctgaaa aatggcaaat ccaactgacc agaaggaagg aggaagctta    420

ttggtggctg ttcctgaagg aggccctgcc ttacaggaac agaagaggaa agagagacac    480

agctgcagag gccacctggc ttgcgcctaa tgtgtttgag catacttagg agaagtcttc    540

tatttattta tttatttatt tatttgtttg ttttagaaga ttctatgtta atattttatg    600

tgtaaaataa ggttatgatt gaatctactt gcacactctc ccattatatt tattgtttat    660

tttaggtcaa acccaagtta gttcaatcct gattcatatt taatttgaag atagaaggtt    720

tgcagatatt ctctagtcat ttgttaatat ttcttcgtga tgacatatca catgtcagcc    780

actgtgatag aggctgagga atccaagaaa atggccagta agatcaatgt gacggcaggg    840

aaatgtatgt gtgtctattt tgtaactgta aagatgaatg tcagttgtta tttattgaaa    900

tgatttcaca gtgtgtggtc aacatttctc atgttgaagc tttaagaact aaaatgttct    960

aaatatccct tggcatttta tgtctttctt gtaagatact gccttgttta atgttaatta   1020

tgcagtgttt ccctctgtgt tagagcagag aggtttcgat atttattgat gttttcacaa   1080

agaacaggaa aataaaatat ttaaaaatat                                    1110


<210>  92
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ala Arg Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Pro Leu Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Lys Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Gln Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Lys Asn Gly Lys Ser Asn 
            100                 105         


<210>  93
<211>  4628
<212>  DNA
<213>  Homo sapiens

<400>  93
tcacttgcct gatatttcca gtgtcagagg gacacagcca acgtggggtc ccttctaggc     60

tgacagccgc tctccagcca ctgccgcgag cccgtctgct cccgccctgc ccgtgcactc    120

tccgcagccg ccctccgcca agccccagcg cccgctccca tcgccgatga ccgcggggag    180

gaggatggag atgctctgtg ccggcagggt ccctgcgctg ctgctctgcc tgggtttcca    240

tcttctacag gcagtcctca gtacaactgt gattccatca tgtatcccag gagagtccag    300

tgataactgc acagctttag ttcagacaga agacaatcca cgtgtggctc aagtgtcaat    360

aacaaagtgt agctctgaca tgaatggcta ttgtttgcat ggacagtgca tctatctggt    420

ggacatgagt caaaactact gcaggtgtga agtgggttat actggtgtcc gatgtgaaca    480

cttcttttta accgtccacc aacctttaag caaagaatat gtggctttga ccgtgattct    540

tattattttg tttcttatca cagtcgtcgg ttccacatat tatttctgca gatggtacag    600

aaatcgaaaa agtaaagaac caaagaagga atatgagaga gttacctcag gggatccaga    660

gttgccgcaa gtctgaatgg cgccatcaaa cttatgggca gggataacag tgtgcctggt    720

taatattaat attcccattt tattaataat atttatgttg ggtcaagtgt taggtcaata    780

acactgtatt ttaatgtact tgaaaaatgt ttttattttt gttttatttt tgacagacta    840

tttgctaatg tataatgtgc agaaaatatt taatatcaaa agaaaattga tatttttata    900

caagtaattt cctgagctaa atgcttcatt gaaagcttca aagtttatat gcctggtgca    960

cagtgcttag aagtaagcaa ttcccaggtc atagctcaag aattgttagc aaatgacaga   1020

tttctgtaag cctatatata tagtcaaatc gatttagtaa gtatgttttt tatgttcctc   1080

aaatcagtga taattggttt gactgtacca tggtttgata tgtagttggc accatggtat   1140

catatattaa aacaataatg caattagaat ttgggagaag caaatatagg tcctgtgtta   1200

aacactacac atttgaaaca agctaaccct ggggagtcta tggtctcttc actcaggtct   1260

cagctataat tctgttatat gaggggcagt ggacagttcc ctatgccaac tcacgactcc   1320

tacaggtact agtcactcat ctaccagatt ctgcctatgt aaaatgaatt gaaaaacaat   1380

tttctgtaat cttttattta agtagtgggc atttcatagc ttcacaatgt tccttttttg   1440

tatattacaa catttatgtg aggtaattat tgctcaacag acaattagaa aaaagtccac   1500

acttgaagcc taaatttgtg ctttttaaga atatttttag actatttctt tttatagggg   1560

ctttgctgaa ttctaacatt aaatcacagc ccaaaatttg atggactaat tattatttta   1620

aaatatatga agacaataat tctacatgtt gtcttaagat ggaaatacag ttatttcatc   1680

ttttattcaa ggaagtttta actttaatac agctcagtaa atggcttctt ctagaatgta   1740

aagttatgta tttaaagttg tatcttgaca caggaaatgg gaaaaaactt aaaaattaat   1800

atggtgtatt tttccaaatg aaaaatctca attgaaagct tttaaaatgt agaaacttaa   1860

acacaccttc ctgtggaggc tgagatgaaa actagggctc attttcctga catttgttta   1920

ttttttggaa gagacaaaga tttcttctgc actctgagcc cataggtctc agagagttaa   1980

taggagtatt tttgggctat tgcataagga gccactgctg ccaccacttt tggattttat   2040

gggaggctcc ttcatcgaat gctaaacctt tgagtagagt ctccctggat cacataccag   2100

gtcagggagg atctgttctt cctctacgtt tatcctggca tgtgctaggg taaacgaagg   2160

cataataagc catggctgac ctctggagca ccaggtgcca ggacttgtct ccatgtgtat   2220

ccatgcatta tataccctgg tgcaatcaca cgactgtcat ctaaagtcct ggccctggcc   2280

cttactatta ggaaaataaa cagacaaaaa caagtaaata tatatggtca tatacatatt   2340

gtatatatat tcatatacaa acatgtatgt atacatgacc ttaatggatc atagaattgc   2400

agtcatttgg tgctctgcta accatttata taaaacttaa aaacaagaga aaagaaaaat   2460

caattagatc taaacagtta tttctgtttc ctatttaata cagctgaagt caaaatatgt   2520

aagaacacat tttaaatact ctacttacag ttggccctct gtggttagtt ccacatctgt   2580

ggattcaacc aaccaaggac ggaaaatgct taaaaaataa tacaacaaca acaaaaaata   2640

cattataaca actatttact tttttttttt tctttttgag atggagtctc gctctgttgc   2700

ccaggttgga gtgcagtggc acgatctcgg ctcactgcaa cctcacctcc cgggttcaag   2760

agatcctcct gcctcagcct cctgagcagc tgggactaca ggcgcatgcc accatgccca   2820

gctaattttt gtatttttag tagaggcggg gtttcaccat gttggccagg atggtctcaa   2880

tctcctaacc ttgagatcca ccctccacag cctcccaaac tgctgggatt acaggtgtga   2940

gccaccgcac gtagcattta cattaggtat tacaagtaat gtaaagatga tttaagtata   3000

caggaggatg tgaataggtt atatgcaagc actatgccct tttatataag tgacttgaac   3060

atctgtgccc gattttagta tgtgcagggg ggcgatctgg gaatcagtcc cctgtggata   3120

ccaaggtaca actgtattta ttaacgctta ctagatgtga ggagagtctg aatattttca   3180

gtgatcttgg ctgtttcaaa aaaatctatt gacttttcaa taaatcagct gcaatccatt   3240

tatttcattt acaaaagatt tattgtaagc atctcaatct tggtttgtca gtttatctta   3300

agcatgtcaa ttcataaaaa caagtcattt ttgtattttt catctttaag aatgcttaaa   3360

aaagctaatc cctaaaatag ttagatcttt gtaaatgcat attaaataat aaagtatgac   3420

ccacattact ttttatgggt gaaaataaga caaaaataat agttttagtg aggatggtgc   3480

tgagtaaaca taaaaactga tttgctctca gctgatgtgt cctgtacaca gtgggaagat   3540

tttagttcac acttagtcta actcccccat tttacagatt tctcactata tatatttcta   3600

gaaggggcta tgcatattca atgtattgag aaccaaagca accacaaatg cataaatgca   3660

taatttatgg tcttcaacca aggccacata ataacccagt taacttactc tttaaccagg   3720

aatattaagt tctataacta gtactcaagg tttaacctta aaattaagat ttccttaacc   3780

ttaaccttaa aattgatatt atattaaaca tacataatac aatgtaactc cactgttctc   3840

ctgaatattt tttgctctaa tctctctgcc gaaagtcaaa gtgatgggag aattggtata   3900

ctggtatgac tacgtcttaa gtcagatttt tatttatgag tctttgagac taaattcaat   3960

caccaccagg tatcaaatca acttttatgc agcaaatata tgattctagt gtctgacttt   4020

tgttaaattc agtaatgcag tttttaaaaa cctgtatctg acccactttg taatttttgc   4080

tccaatatcc attctgtaga cttttgaaaa aaaagttttt aatttgatgc ccaatatatt   4140

ctgaccgtta aaaaattctt gttcatatgg gagaaggggg agtaatgact tgtacaaaca   4200

gtatttctgg tgtatatttt aatgttttta aaaagagtaa tttcatttaa atatctgtta   4260

ttcaaatttg atgatgttaa atgtaatata atgtattttc tttttatttt gcactctgta   4320

attgcacttt ttaagtttga agagccattt tggtaaacgg tttttattaa agatgctatg   4380

gaacataaag ttgtattgca tgcaatttga agtaacttat ttgactatga atgttatcgg   4440

attactgaat tgtatcaatt tgtttgtgtt caatatcagc tttgataatt gtgtacctta   4500

agatattgaa ggagaaaata gataatttac aagatattat taatttttat ttatttttct   4560

tgggaattga aaaaaattga aataaataaa aatgcattga acatcttgca ttcaaaatct   4620

tcactgac                                                            4628


<210>  94
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Thr Ala Gly Arg Arg Met Glu Met Leu Cys Ala Gly Arg Val Pro 
1               5                   10                  15      


Ala Leu Leu Leu Cys Leu Gly Phe His Leu Leu Gln Ala Val Leu Ser 
            20                  25                  30          


Thr Thr Val Ile Pro Ser Cys Ile Pro Gly Glu Ser Ser Asp Asn Cys 
        35                  40                  45              


Thr Ala Leu Val Gln Thr Glu Asp Asn Pro Arg Val Ala Gln Val Ser 
    50                  55                  60                  


Ile Thr Lys Cys Ser Ser Asp Met Asn Gly Tyr Cys Leu His Gly Gln 
65                  70                  75                  80  


Cys Ile Tyr Leu Val Asp Met Ser Gln Asn Tyr Cys Arg Cys Glu Val 
                85                  90                  95      


Gly Tyr Thr Gly Val Arg Cys Glu His Phe Phe Leu Thr Val His Gln 
            100                 105                 110         


Pro Leu Ser Lys Glu Tyr Val Ala Leu Thr Val Ile Leu Ile Ile Leu 
        115                 120                 125             


Phe Leu Ile Thr Val Val Gly Ser Thr Tyr Tyr Phe Cys Arg Trp Tyr 
    130                 135                 140                 


Arg Asn Arg Lys Ser Lys Glu Pro Lys Lys Glu Tyr Glu Arg Val Thr 
145                 150                 155                 160 


Ser Gly Asp Pro Glu Leu Pro Gln Val 
                165                 


<210>  95
<211>  1802
<212>  DNA
<213>  Homo sapiens

<400>  95
gggcagctcc accctgggag ggactgtggc ccaggtactg cccgggtgct actttatggg     60

cagcagctca gttgagttag agtctggaag acctcagaag acctcctgtc ctatgaggcc    120

ctccccatgg ctttagagac gatctgccga ccctctggga gaaaatccag caagatgcaa    180

gccttcagaa tctgggatgt taaccagaag accttctatc tgaggaacaa ccaactagtt    240

gctggatact tgcaaggacc aaatgtcaat ttagaagaaa agatagatgt ggtacccatt    300

gagcctcatg ctctgttctt gggaatccat ggagggaaga tgtgcctgtc ctgtgtcaag    360

tctggtgatg agaccagact ccagctggag gcagttaaca tcactgacct gagcgagaac    420

agaaagcagg acaagcgctt cgccttcatc cgctcagaca gcggccccac caccagtttt    480

gagtctgccg cctgccccgg ttggttcctc tgcacagcga tggaagctga ccagcccgtc    540

agcctcacca atatgcctga cgaaggcgtc atggtcacca aattctactt ccaggaggac    600

gagtagtact gcccaggcct gcctgttccc attcttgcat ggcaaggact gcagggactg    660

ccagtccccc tgccccaggg ctcccggcta tgggggcact gaggaccagc cattgagggg    720

tggaccctca gaaggcgtca caagaacctg gtcacaggac tctgcctcct cttcaactga    780

ccagcctcca tgctgcctcc agaatggtct ttctaatgtg tgaatcagag cacagcagcc    840

cctgcacaaa gcccttccat gtcgcctctg cattcaggat caaaccccga ccacctgccc    900

aacctgctct cctcttgcca ctgcctcttc ctccctcatt ccaccttccc atgccctgga    960

tccatcaggc cacttgatga cccccaacca agtggctccc acaccctgtt ttacaaaaaa   1020

gaaaagacca gtccatgagg gaggttttta agggtttgtg gaaaatgaaa attaggattt   1080

catgattttt ttttttcagt ccccgtgaag gagagccctt catttggaga ttatgttctt   1140

tcggggagag gctgaggact taaaatattc ctgcatttgt gaaatgatgg tgaaagtaag   1200

tggtagcttt tcccttcttt ttcttctttt tttgtgatgt cccaacttgt aaaaattaaa   1260

agttatggta ctatgttagc cccataattt tttttttcct tttaaaacac ttccataatc   1320

tggactcctc tgtccaggca ctgctgccca gcctccaagc tccatctcca ctccagattt   1380

tttacagctg cctgcagtac tttacctcct atcagaagtt tctcagctcc caaggctctg   1440

agcaaatgtg gctcctgggg gttctttctt cctctgctga aggaataaat tgctccttga   1500

cattgtagag cttctggcac ttggagactt gtatgaaaga tggctgtgcc tctgcctgtc   1560

tcccccaccg ggctgggagc tctgcagagc aggaaacatg actcgtatat gtctcaggtc   1620

cctgcagggc caagcaccta gcctcgctct tggcaggtac tcagcgaatg aatgctgtat   1680

atgttgggtg caaagttccc tacttcctgt gacttcagct ctgttttaca ataaaatctt   1740

gaaaatgcct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1800

aa                                                                  1802


<210>  96
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 


<210>  97
<211>  6853
<212>  DNA
<213>  Homo sapiens

<400>  97
atacatagac ttccgttaaa accagaatga ggaaaatact tttctctagc atcgtaggag     60

gaagaaaaca aacacatcag atattttcag cactaaaaga gatggttttc cccacatata    120

tgtaaaagaa atttgcaaga ctactggatt ttgatctcat ggttgcagtg ggtgaatagg    180

tggccttttg tgatctccta catcaccctg gaagtgagac ttcttcggtt tcttctagag    240

tcagtttggt atcagaatgg caaagcaact taaccttcca gaaaatacag atgattggac    300

aaaagaggat gtaaatcagt ggttagaaag tcataagatt gaccaaaaac acagggaaat    360

tttgactgaa caagacgtga atggagcagt cttgaagtgg ttaaaaaaag aacatcttgt    420

tgatatgggc atcacacatg gaccagctat tcaaatagaa gaactattca aagaattgcg    480

gaaaacagcc attgaagatt cgattcagac atctaagatg ggaaagccca gtaaaaatgc    540

tcctaaagac caaactgtgt ctcaaaagga acgtagagaa acttcaaagc aaaaacaaaa    600

gggtaaagag aacccagata tggctaatcc gtctgcaatg agtacaactg ctaaaggttc    660

taagtcacta aaagttgagc tcatagaaga taaaatagat tatacaaagg aaaggcaacc    720

atccatagac ctgacatgtg tatcatatcc atttgatgaa ttcagtaatc catatcgtta    780

caagttggat tttagtctac agcctgaaac aggaccaggc aatctcattg atccgataca    840

tgaattcaaa gccttcacaa atacagcaac agccacagaa gaggatgtca agatgaaatt    900

tagcaatgag gttttccgat ttgcttcagc ttgtatgaat tcacgtacca atggcactat    960

tcattttgga gtcaaagaca aaccccatgg gaaaattgtt ggcatcaaag tcaccaatga   1020

taccaaggaa gccctcatta accatttcaa tctgatgata aacaagtatt ttgaagacca   1080

tcaagtccaa caagcaaaga agtgcattcg agagccaaga tttgtggaag ttttactgcc   1140

aaatagtact ctatctgaca gatttgttat tgaagtggac attattccac agttctctga   1200

atgccaatat gattatttcc agattaaaat gcaaaattac aacaacaaaa tatgggaaca   1260

aagtaaaaaa ttctcactat ttgtgcgaga tgggaccagc tctaaggaca ttacgaaaaa   1320

taaagttgat ttcagagcat ttaaagcaga ttttaaaaca ctggcagagt ccagaaaagc   1380

agcagaagaa aaattcagag caaaaacaaa taaaaaagaa agagagggac caaagttggt   1440

taaattattg acaggaaatc aagatttgtt agataattca tactatgaac agtacattct   1500

tgtaacaaat aaatgccacc cagatcaaac aaaacactta gatttcctga aggaaattaa   1560

atggtttgct gtattggagt ttgatcctga gtctaacatc aatggagtgg tcaaagctta   1620

caaagaaagc cgagtagcaa accttcactt tccaagtgta tatgtagaac agaaaaccac   1680

accaaatgag acgatttcta ctctaaatct ttaccatcaa cccagctgga ttttctgcaa   1740

tggcaggtta gaccttgaca gtgaaaaata taaacccttt gatccaagtt cctggcaaag   1800

agaaagagct tctgatgtca ggaaactgat ttcatttctt acacatgaag acataatgcc   1860

aagagggaag tttttggtgg tatttctatt actgtcctct gtggatgacc caagagatcc   1920

cctcattgag actttctgtg ctttctacca ggatctcaaa ggaatggaaa atatactgtg   1980

tatttgtgtg cacccacaca tatttcaggg atggaaagat ctacttgaag caagattaat   2040

aaaacaccaa gatgaaattt caagccaatg tatttctgct ttaagccttg aagagatcaa   2100

tggcactatt cttaaactaa aatctgtgac tcaatcttca aaaaggcttt tgccatctat   2160

tggtttatcg actgtccttc tgaaaaagga agaagatatc atgactgctc tggaaattat   2220

ctgtgaaaat gaatgtgagg gtacactgtt agagaaggac aaaaataaat tccttgaatt   2280

caaggcatca aaagaggaag acttctatcg aggtggcaaa gtgtcatggt ggaacttcta   2340

cttctcttct gaaagttatt cttcaccttt tgtcaaaagg gataaatatg aaagacttga   2400

agcaatgatt caaaactgtg cagattcttc taaaccaaca agtaccaaaa ttattcatct   2460

gtatcatcat ccaggctgtg ggggaactac cttggctatg cacattctct gggaactaag   2520

gaagaaattc agatgtgctg tgctgaaaaa caagacagtg gatttttctg aaattggaga   2580

acaggtaacc agtttaatca cctatggggc aatgaaccgt caggaatacg tacctgtact   2640

actccttgtt gatgattttg aagaacaaga taatgtctat cttctgcagt actctattca   2700

aacagctata gctaaaaagt acattcgata tgaaaaacct ctggtgatta tcctaaattg   2760

tatgagatca caaaatcctg aaaaaagtgc aaggatccca gacagtattg ccgtaataca   2820

gcaactctct cccaaagaac agagagcttt tgagcttaaa ttgaaagaaa tcaaagaaca   2880

gcataaaaac tttgaggatt tttattcctt tatgatcatg aaaaccaatt ttaataaaga   2940

atacatagaa aatgtggtcc ggaatatcct gaaagggcag aatattttca ccaaggaagc   3000

aaagctcttt tcttttctgg ctcttcttaa ttcatatgtg cctgatacca ccatttcact   3060

atcacagtgt gaaaaattct taggaattgg aaacaagaag gctttctggg ggacagaaaa   3120

atttgaagac aagatgggca cctactctac aattctgata aaaacagagg tcatcgaatg   3180

tgggaactac tgtggagtac gcatcattca ctctttgatt gcagagttct cactggaaga   3240

attgaagaaa agctatcacc tgaataaaag tcaaattatg ttggatatgc taactgagaa   3300

tttgttcttc gatactggta tgggaaaaag taaatttttg caagatatgc acacactcct   3360

actcacaaga caccgcgatg aacatgaagg tgaaacagga aattggtttt ccccatttat   3420

tgaagcatta cataaagatg aaggaaatga agcagttgaa gctgtattgc ttgaaagtat   3480

ccatcggttc aacccaaatg cattcatttg ccaagcgttg gcaagacatt tctacattaa   3540

aaagaaggac tttggcaatg ctctaaactg ggcaaaacaa gcaaaaatca tagaacctga   3600

caattcttat atctcagata cactgggtca agtctacaaa agtaaaataa gatggtggat   3660

agaggaaaac ggaggaaacg ggaacatttc agttgatgat ctaattgctc ttttggattt   3720

agcagaacat gcctcaagtg cattcaaaga atctcaacag caaagtgaag atagagagta   3780

tgaagtgaag gaaagattgt atccgaagtc aaaaaggcgg tatgatactt acaatatagc   3840

tggttatcaa ggagagatag aagttgggct ttacacaatc caaattctcc agctcattcc   3900

tttttttgat aataaaaatg agctatctaa aagatatatg gtcaattttg tatcaggaag   3960

tagtgatatt ccaggggatc caaacaatga atataaatta gccctcaaaa actatattcc   4020

ttatttaact aaattgaaat tttctttgaa aaagtccttt gatttttttg atgaatactt   4080

tgtcctgcta aaacccagga acaatattaa gcaaaatgaa gaggccaaaa ctcggagaaa   4140

ggtggctgga tattttaaga aatatgtaga tatattttgt ctcttagaag aatcacaaaa   4200

caacacaggt cttggatcaa agttcagtga gccacttcaa gtagagagat gcaggagaaa   4260

cctagtagct ttaaaagcag acaagttttc tgggctcttg gaatatctta tcaaaagtca   4320

agaggatgct ataagcacta tgaaatgtat agtgaacgaa tatacttttc tcttagaaca   4380

atgcactgtc aaaatccagt caaaagaaaa gctaaatttc atcttggcca acattattct   4440

ctcctgtatc caacctacct ccagattagt aaagccagtt gaaaaactaa aagatcagct   4500

tcgagaagtc ttgcaaccaa taggactgac ttatcagttt tcagaaccgt attttctagc   4560

ttccctctta ttctggccag aaaatcaaca actagatcaa cattctgaac aaatgaaaga   4620

gtatgctcaa gcactaaaaa attctttcaa ggggcaatat aaacatatgc atcgtacaaa   4680

gcaaccaatt gcatatttct ttcttggaaa aggtaaaaga ctggaaagac ttgttcacaa   4740

aggaaaaatt gaccagtgct ttaagaagac accagatatt aattccttgt ggcagagtgg   4800

agatgtgtgg aaggaggaaa aagtccaaga acttttgctt cgtttacaag gtcgagctga   4860

aaacaattgt ttatatatag aatatggaat caatgaaaaa atcacaatac ccatcactcc   4920

cgctttttta ggtcaactta gaagtggcag aagcatagag aaggtgtctt tttacctggg   4980

attttccatt ggaggcccac ttgcttatga cattgaaatt gtttaagagc ctgatattct   5040

tcctccaaga atttgatctc agtacccatt taattttttt ggactcaaga tctatgcttt   5100

aaaccggcaa ggttatagat acagcctcta gctcttcaga tctgtacatg cagtatttaa   5160

tttcctctta aacatgttat gagttctaca aagacaatag tgaaaaagga aggagtgaga   5220

tatatgaaaa gtagcaaata tgttccttgg tttggttaac atcattgatg acaaaataat   5280

aaggagctat gactggagtc aggagaagtt agtgtaataa gctggctaca cagaacccca   5340

ctacttacca ggcatggatt gaagaagatt gtctactcaa atggcattta gacattagaa   5400

tgtctgggaa aatatttctc aaagacagca aaaacctctc aaactgagga gcaacattta   5460

ttcttactaa gcagatcatc aatgtatcat gtgcttggca ctcaaggatc ttccaaaaca   5520

gaggaccaac cagtcttctg aaggtcatgc ccacagaagt catcagacct taccaaagta   5580

ggttggagaa ttagattgcc ttttcatgca gtgagattca gttaagcaaa aatgaaattt   5640

gtctctatag ctaattagct tatcaactcc cctccaaaca aacaattaaa aaaaaaacat   5700

acagacactc aaattccaca agctaatgaa caaaagggac tcttgtgaga agactaatga   5760

gtccctcatc cagaagatgc caatgtactg gcagattaac atacaaccta tgttttgaac   5820

aaaaacaacc agcgatacgt aatcaaaatg taattttccc ctaataaaat tatggatatg   5880

ggcagtcatc aatggctgcc aaaaccatta agtggaaagc tgattaaaaa acaaaaattt   5940

ctaatggatt tatcaaactg tcccaaatcc tgataaatat taacatcaca gaggaagacc   6000

agacattatg ggcctggaag tactatagga gtgcacacat cacccgtgac atggtcttgc   6060

caaataatta aacctgaatt tgatcaggtc tctggatctt atttgcaatt caaaagaaat   6120

tttaaaaaaa tcctactaac accaccacaa atatgcaatc agcaatatcc agaaagggga   6180

aattcacagg acaaaaacct ggttttcttt tttggtttct tcaaccaaaa aagaaagaaa   6240

ttgcaaagga ccaaaaaaat gttggggaat ctatacatta taagggactt aacaactaaa   6300

gggcaacata tagactttag atcctaattt gagcaaaatc taaaatcaat tattaggcaa   6360

tcagaaaaat ttgaacacag actagatatt tgaggatatt aaggtactat attattgaag   6420

attccatggt tatgtttttt aaagagttca tgccttttag agatacatac taaagtattt   6480

gtaaataaat gacatgatct agaatcagta attttgtgtt tggggtgtgg gggtggtgaa   6540

agggaagtag aaccgaaaca agattagtcc tgagttaaca atggctgcaa gctggataca   6600

tggaattcag cacacttttc tccctcttac tgattatgct tttgaaattt tctcttgtaa   6660

aacatttaga aaacaaaaac aaaaaaaatg tgatttgttt ctgtcttcaa aatctcatta   6720

gaattttttc actggaggaa gattttccct tgcttctgca taaaatttta actccataac   6780

ttataagctc actctttatt gttactttct aattgacaaa taaaaattgt atattaaaaa   6840

aaaaaaaaaa aaa                                                      6853


<210>  98
<211>  1589
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Ala Lys Gln Leu Asn Leu Pro Glu Asn Thr Asp Asp Trp Thr Lys 
1               5                   10                  15      


Glu Asp Val Asn Gln Trp Leu Glu Ser His Lys Ile Asp Gln Lys His 
            20                  25                  30          


Arg Glu Ile Leu Thr Glu Gln Asp Val Asn Gly Ala Val Leu Lys Trp 
        35                  40                  45              


Leu Lys Lys Glu His Leu Val Asp Met Gly Ile Thr His Gly Pro Ala 
    50                  55                  60                  


Ile Gln Ile Glu Glu Leu Phe Lys Glu Leu Arg Lys Thr Ala Ile Glu 
65                  70                  75                  80  


Asp Ser Ile Gln Thr Ser Lys Met Gly Lys Pro Ser Lys Asn Ala Pro 
                85                  90                  95      


Lys Asp Gln Thr Val Ser Gln Lys Glu Arg Arg Glu Thr Ser Lys Gln 
            100                 105                 110         


Lys Gln Lys Gly Lys Glu Asn Pro Asp Met Ala Asn Pro Ser Ala Met 
        115                 120                 125             


Ser Thr Thr Ala Lys Gly Ser Lys Ser Leu Lys Val Glu Leu Ile Glu 
    130                 135                 140                 


Asp Lys Ile Asp Tyr Thr Lys Glu Arg Gln Pro Ser Ile Asp Leu Thr 
145                 150                 155                 160 


Cys Val Ser Tyr Pro Phe Asp Glu Phe Ser Asn Pro Tyr Arg Tyr Lys 
                165                 170                 175     


Leu Asp Phe Ser Leu Gln Pro Glu Thr Gly Pro Gly Asn Leu Ile Asp 
            180                 185                 190         


Pro Ile His Glu Phe Lys Ala Phe Thr Asn Thr Ala Thr Ala Thr Glu 
        195                 200                 205             


Glu Asp Val Lys Met Lys Phe Ser Asn Glu Val Phe Arg Phe Ala Ser 
    210                 215                 220                 


Ala Cys Met Asn Ser Arg Thr Asn Gly Thr Ile His Phe Gly Val Lys 
225                 230                 235                 240 


Asp Lys Pro His Gly Lys Ile Val Gly Ile Lys Val Thr Asn Asp Thr 
                245                 250                 255     


Lys Glu Ala Leu Ile Asn His Phe Asn Leu Met Ile Asn Lys Tyr Phe 
            260                 265                 270         


Glu Asp His Gln Val Gln Gln Ala Lys Lys Cys Ile Arg Glu Pro Arg 
        275                 280                 285             


Phe Val Glu Val Leu Leu Pro Asn Ser Thr Leu Ser Asp Arg Phe Val 
    290                 295                 300                 


Ile Glu Val Asp Ile Ile Pro Gln Phe Ser Glu Cys Gln Tyr Asp Tyr 
305                 310                 315                 320 


Phe Gln Ile Lys Met Gln Asn Tyr Asn Asn Lys Ile Trp Glu Gln Ser 
                325                 330                 335     


Lys Lys Phe Ser Leu Phe Val Arg Asp Gly Thr Ser Ser Lys Asp Ile 
            340                 345                 350         


Thr Lys Asn Lys Val Asp Phe Arg Ala Phe Lys Ala Asp Phe Lys Thr 
        355                 360                 365             


Leu Ala Glu Ser Arg Lys Ala Ala Glu Glu Lys Phe Arg Ala Lys Thr 
    370                 375                 380                 


Asn Lys Lys Glu Arg Glu Gly Pro Lys Leu Val Lys Leu Leu Thr Gly 
385                 390                 395                 400 


Asn Gln Asp Leu Leu Asp Asn Ser Tyr Tyr Glu Gln Tyr Ile Leu Val 
                405                 410                 415     


Thr Asn Lys Cys His Pro Asp Gln Thr Lys His Leu Asp Phe Leu Lys 
            420                 425                 430         


Glu Ile Lys Trp Phe Ala Val Leu Glu Phe Asp Pro Glu Ser Asn Ile 
        435                 440                 445             


Asn Gly Val Val Lys Ala Tyr Lys Glu Ser Arg Val Ala Asn Leu His 
    450                 455                 460                 


Phe Pro Ser Val Tyr Val Glu Gln Lys Thr Thr Pro Asn Glu Thr Ile 
465                 470                 475                 480 


Ser Thr Leu Asn Leu Tyr His Gln Pro Ser Trp Ile Phe Cys Asn Gly 
                485                 490                 495     


Arg Leu Asp Leu Asp Ser Glu Lys Tyr Lys Pro Phe Asp Pro Ser Ser 
            500                 505                 510         


Trp Gln Arg Glu Arg Ala Ser Asp Val Arg Lys Leu Ile Ser Phe Leu 
        515                 520                 525             


Thr His Glu Asp Ile Met Pro Arg Gly Lys Phe Leu Val Val Phe Leu 
    530                 535                 540                 


Leu Leu Ser Ser Val Asp Asp Pro Arg Asp Pro Leu Ile Glu Thr Phe 
545                 550                 555                 560 


Cys Ala Phe Tyr Gln Asp Leu Lys Gly Met Glu Asn Ile Leu Cys Ile 
                565                 570                 575     


Cys Val His Pro His Ile Phe Gln Gly Trp Lys Asp Leu Leu Glu Ala 
            580                 585                 590         


Arg Leu Ile Lys His Gln Asp Glu Ile Ser Ser Gln Cys Ile Ser Ala 
        595                 600                 605             


Leu Ser Leu Glu Glu Ile Asn Gly Thr Ile Leu Lys Leu Lys Ser Val 
    610                 615                 620                 


Thr Gln Ser Ser Lys Arg Leu Leu Pro Ser Ile Gly Leu Ser Thr Val 
625                 630                 635                 640 


Leu Leu Lys Lys Glu Glu Asp Ile Met Thr Ala Leu Glu Ile Ile Cys 
                645                 650                 655     


Glu Asn Glu Cys Glu Gly Thr Leu Leu Glu Lys Asp Lys Asn Lys Phe 
            660                 665                 670         


Leu Glu Phe Lys Ala Ser Lys Glu Glu Asp Phe Tyr Arg Gly Gly Lys 
        675                 680                 685             


Val Ser Trp Trp Asn Phe Tyr Phe Ser Ser Glu Ser Tyr Ser Ser Pro 
    690                 695                 700                 


Phe Val Lys Arg Asp Lys Tyr Glu Arg Leu Glu Ala Met Ile Gln Asn 
705                 710                 715                 720 


Cys Ala Asp Ser Ser Lys Pro Thr Ser Thr Lys Ile Ile His Leu Tyr 
                725                 730                 735     


His His Pro Gly Cys Gly Gly Thr Thr Leu Ala Met His Ile Leu Trp 
            740                 745                 750         


Glu Leu Arg Lys Lys Phe Arg Cys Ala Val Leu Lys Asn Lys Thr Val 
        755                 760                 765             


Asp Phe Ser Glu Ile Gly Glu Gln Val Thr Ser Leu Ile Thr Tyr Gly 
    770                 775                 780                 


Ala Met Asn Arg Gln Glu Tyr Val Pro Val Leu Leu Leu Val Asp Asp 
785                 790                 795                 800 


Phe Glu Glu Gln Asp Asn Val Tyr Leu Leu Gln Tyr Ser Ile Gln Thr 
                805                 810                 815     


Ala Ile Ala Lys Lys Tyr Ile Arg Tyr Glu Lys Pro Leu Val Ile Ile 
            820                 825                 830         


Leu Asn Cys Met Arg Ser Gln Asn Pro Glu Lys Ser Ala Arg Ile Pro 
        835                 840                 845             


Asp Ser Ile Ala Val Ile Gln Gln Leu Ser Pro Lys Glu Gln Arg Ala 
    850                 855                 860                 


Phe Glu Leu Lys Leu Lys Glu Ile Lys Glu Gln His Lys Asn Phe Glu 
865                 870                 875                 880 


Asp Phe Tyr Ser Phe Met Ile Met Lys Thr Asn Phe Asn Lys Glu Tyr 
                885                 890                 895     


Ile Glu Asn Val Val Arg Asn Ile Leu Lys Gly Gln Asn Ile Phe Thr 
            900                 905                 910         


Lys Glu Ala Lys Leu Phe Ser Phe Leu Ala Leu Leu Asn Ser Tyr Val 
        915                 920                 925             


Pro Asp Thr Thr Ile Ser Leu Ser Gln Cys Glu Lys Phe Leu Gly Ile 
    930                 935                 940                 


Gly Asn Lys Lys Ala Phe Trp Gly Thr Glu Lys Phe Glu Asp Lys Met 
945                 950                 955                 960 


Gly Thr Tyr Ser Thr Ile Leu Ile Lys Thr Glu Val Ile Glu Cys Gly 
                965                 970                 975     


Asn Tyr Cys Gly Val Arg Ile Ile His Ser Leu Ile Ala Glu Phe Ser 
            980                 985                 990         


Leu Glu Glu Leu Lys Lys Ser Tyr  His Leu Asn Lys Ser  Gln Ile Met 
        995                 1000                 1005             


Leu Asp  Met Leu Thr Glu Asn  Leu Phe Phe Asp Thr  Gly Met Gly 
    1010                 1015                 1020             


Lys Ser  Lys Phe Leu Gln Asp  Met His Thr Leu Leu  Leu Thr Arg 
    1025                 1030                 1035             


His Arg  Asp Glu His Glu Gly  Glu Thr Gly Asn Trp  Phe Ser Pro 
    1040                 1045                 1050             


Phe Ile  Glu Ala Leu His Lys  Asp Glu Gly Asn Glu  Ala Val Glu 
    1055                 1060                 1065             


Ala Val  Leu Leu Glu Ser Ile  His Arg Phe Asn Pro  Asn Ala Phe 
    1070                 1075                 1080             


Ile Cys  Gln Ala Leu Ala Arg  His Phe Tyr Ile Lys  Lys Lys Asp 
    1085                 1090                 1095             


Phe Gly  Asn Ala Leu Asn Trp  Ala Lys Gln Ala Lys  Ile Ile Glu 
    1100                 1105                 1110             


Pro Asp  Asn Ser Tyr Ile Ser  Asp Thr Leu Gly Gln  Val Tyr Lys 
    1115                 1120                 1125             


Ser Lys  Ile Arg Trp Trp Ile  Glu Glu Asn Gly Gly  Asn Gly Asn 
    1130                 1135                 1140             


Ile Ser  Val Asp Asp Leu Ile  Ala Leu Leu Asp Leu  Ala Glu His 
    1145                 1150                 1155             


Ala Ser  Ser Ala Phe Lys Glu  Ser Gln Gln Gln Ser  Glu Asp Arg 
    1160                 1165                 1170             


Glu Tyr  Glu Val Lys Glu Arg  Leu Tyr Pro Lys Ser  Lys Arg Arg 
    1175                 1180                 1185             


Tyr Asp  Thr Tyr Asn Ile Ala  Gly Tyr Gln Gly Glu  Ile Glu Val 
    1190                 1195                 1200             


Gly Leu  Tyr Thr Ile Gln Ile  Leu Gln Leu Ile Pro  Phe Phe Asp 
    1205                 1210                 1215             


Asn Lys  Asn Glu Leu Ser Lys  Arg Tyr Met Val Asn  Phe Val Ser 
    1220                 1225                 1230             


Gly Ser  Ser Asp Ile Pro Gly  Asp Pro Asn Asn Glu  Tyr Lys Leu 
    1235                 1240                 1245             


Ala Leu  Lys Asn Tyr Ile Pro  Tyr Leu Thr Lys Leu  Lys Phe Ser 
    1250                 1255                 1260             


Leu Lys  Lys Ser Phe Asp Phe  Phe Asp Glu Tyr Phe  Val Leu Leu 
    1265                 1270                 1275             


Lys Pro  Arg Asn Asn Ile Lys  Gln Asn Glu Glu Ala  Lys Thr Arg 
    1280                 1285                 1290             


Arg Lys  Val Ala Gly Tyr Phe  Lys Lys Tyr Val Asp  Ile Phe Cys 
    1295                 1300                 1305             


Leu Leu  Glu Glu Ser Gln Asn  Asn Thr Gly Leu Gly  Ser Lys Phe 
    1310                 1315                 1320             


Ser Glu  Pro Leu Gln Val Glu  Arg Cys Arg Arg Asn  Leu Val Ala 
    1325                 1330                 1335             


Leu Lys  Ala Asp Lys Phe Ser  Gly Leu Leu Glu Tyr  Leu Ile Lys 
    1340                 1345                 1350             


Ser Gln  Glu Asp Ala Ile Ser  Thr Met Lys Cys Ile  Val Asn Glu 
    1355                 1360                 1365             


Tyr Thr  Phe Leu Leu Glu Gln  Cys Thr Val Lys Ile  Gln Ser Lys 
    1370                 1375                 1380             


Glu Lys  Leu Asn Phe Ile Leu  Ala Asn Ile Ile Leu  Ser Cys Ile 
    1385                 1390                 1395             


Gln Pro  Thr Ser Arg Leu Val  Lys Pro Val Glu Lys  Leu Lys Asp 
    1400                 1405                 1410             


Gln Leu  Arg Glu Val Leu Gln  Pro Ile Gly Leu Thr  Tyr Gln Phe 
    1415                 1420                 1425             


Ser Glu  Pro Tyr Phe Leu Ala  Ser Leu Leu Phe Trp  Pro Glu Asn 
    1430                 1435                 1440             


Gln Gln  Leu Asp Gln His Ser  Glu Gln Met Lys Glu  Tyr Ala Gln 
    1445                 1450                 1455             


Ala Leu  Lys Asn Ser Phe Lys  Gly Gln Tyr Lys His  Met His Arg 
    1460                 1465                 1470             


Thr Lys  Gln Pro Ile Ala Tyr  Phe Phe Leu Gly Lys  Gly Lys Arg 
    1475                 1480                 1485             


Leu Glu  Arg Leu Val His Lys  Gly Lys Ile Asp Gln  Cys Phe Lys 
    1490                 1495                 1500             


Lys Thr  Pro Asp Ile Asn Ser  Leu Trp Gln Ser Gly  Asp Val Trp 
    1505                 1510                 1515             


Lys Glu  Glu Lys Val Gln Glu  Leu Leu Leu Arg Leu  Gln Gly Arg 
    1520                 1525                 1530             


Ala Glu  Asn Asn Cys Leu Tyr  Ile Glu Tyr Gly Ile  Asn Glu Lys 
    1535                 1540                 1545             


Ile Thr  Ile Pro Ile Thr Pro  Ala Phe Leu Gly Gln  Leu Arg Ser 
    1550                 1555                 1560             


Gly Arg  Ser Ile Glu Lys Val  Ser Phe Tyr Leu Gly  Phe Ser Ile 
    1565                 1570                 1575             


Gly Gly  Pro Leu Ala Tyr Asp  Ile Glu Ile Val 
    1580                 1585                 


<210>  99
<211>  3981
<212>  DNA
<213>  Homo sapiens

<400>  99
cgacaggggc ggctctttcc tgggtggggt ttgtgaagtc gtggcccgtt agcaggaagc     60

ctaacagtcg ccccgacgct agtgagggac ccaatctgag tccccggcca gccgaatcca    120

agccgtgtgt actgcgtgct cagcactgcc cgacagtcct agctaaactt cgccaactcc    180

gctgcctttg ccgccaccat gcccaaaacg atcagtgtgc gtgtgaccac catggatgca    240

gagctggagt ttgccatcca gcccaacacc accgggaagc agctatttga ccaggtggtg    300

aaaactattg gcttgaggga agtttggttc tttggtctgc agtaccagga cactaaaggt    360

ttctccacct ggctgaaact caataagaag gtgactgccc aggatgtgcg gaaggaaagc    420

cccctgctct ttaagttccg tgccaagttc taccctgagg atgtgtccga ggaattgatt    480

caggacatca ctcagcgcct gttctttctg caagtgaaag agggcattct caatgatgat    540

atttactgcc cgcctgagac cgctgtgctg ctggcctcgt atgctgtcca gtctaagtat    600

ggcgacttca ataaggaagt gcataagtct ggctacctgg ccggagacaa gttgctcccg    660

cagagagtcc tggaacagca caaactcaac aaggaccagt gggaggagcg gatccaggtg    720

tggcatgagg aacaccgtgg catgctcagg gaggatgctg tcctggaata tctgaagatt    780

gctcaagatc tggagatgta tggtgtgaac tacttcagca tcaagaacaa gaaaggctca    840

gagctgtggc tgggggtgga tgccctgggt ctcaacatct atgagcagaa tgacagacta    900

actcccaaga taggcttccc ctggagtgaa atcaggaaca tctctttcaa tgataagaaa    960

tttgtcatca agcccattga caaaaaagcc ccggacttcg tcttctatgc tccccggctg   1020

cggattaaca agcggatctt ggccttgtgc atggggaacc atgaactata catgcgccgt   1080

cgcaagcctg ataccattga ggtgcagcag atgaaggcac aggcccggga ggagaagcac   1140

cagaagcaga tggagcgtgc tatgctggaa aatgagaaga agaagcgtga aatggcagag   1200

aaggagaaag agaagattga acgggagaag gaggagctga tggagaggct gaagcagatc   1260

gaggaacaga ctaagaaggc tcagcaagaa ctggaagaac agacccgtag ggctctggaa   1320

cttgagcagg aacggaagcg tgcccagagc gaggctgaaa agctggccaa ggagcgtcaa   1380

gaagctgaag aggccaagga ggccttgctg caggcctccc gggaccagaa aaagactcag   1440

gaacagctgg ccttggaaat ggcagagctg acagctcgaa tctcccagct ggagatggcc   1500

cgacagaaga aggagagtga ggctgtggag tggcagcaga aggcccagat ggtacaggaa   1560

gacttggaga agacccgtgc tgagctgaag actgccatga gtacacctca tgtggcagag   1620

cctgctgaga atgagcagga tgagcaggat gagaatgggg cagaggctag tgctgaccta   1680

cgggctgatg ctatggccaa ggaccgcagt gaggaggaac gtaccactga ggcagagaag   1740

aatgagcgtg tgcagaagca cctgaaggcc ctcacttcgg agctggccaa tgccagagat   1800

gagtccaaga agactgccaa tgacatgatc catgctgaga acatgcgact gggccgagac   1860

aaatacaaga ccctgcgcca gatccggcag ggcaacacca agcagcgcat tgacgaattt   1920

gagtctatgt aatgggcacc cagcctctag ggacccctcc tccctttttc cttgtcccca   1980

cactcctaca cctaactcac ctaactcata ctgtgctgga gccactaact agagcagccc   2040

tggagtcatg ccaagcattt aatgtagcca tgggaccaaa cctagcccct tagcccccac   2100

ccacttccct gggcaaatga atggctcact atggtgccaa tggaacctcc tttctcttct   2160

ctgttccatt gaatctgtat ggctagaata tcctacttct ccagcctaga ggtactttcc   2220

acttgatttt gcaaatgccc ttacacttac tgttgtccta tgggagtcaa gtgtggagta   2280

ggttggaagc tagctcccct cctctcccct accactgtct tcttcagggt cctgagattt   2340

acacggttgg agtgttatgc ggtctaggga atgagacagg acctaggata tcttctccag   2400

gatgtcaact gacctaaaat ttgccctccc atcccgttta gagttattta ggctttgtaa   2460

cgattggggg ataaaaagat gttcagtcat ttttgtttct acctcccaga tcggatctgt   2520

tgcaaactca gcctcaataa gccttgtcgt tgactttagg gactcaattt ctccccaggg   2580

tggatggggg aaatggtgcc ttcaagacct tcaccaaaca tactagaagg gcattggcca   2640

ttctattgtg gcaaggctga gtagaagatc ctaccccaat tccttgtagg agtataggcc   2700

ggtctaaagt gagctctatg ggcagatcta ccccttactt attattccag atctgcagtc   2760

acttcgtggg atctgcccct ccctgcttca atacccaaat cctctccagc tataacagta   2820

gggatgagta cccaaaagct cagccagccc catcaggact cttgtgaaaa gagaggatat   2880

gttcacacct agcgtcagta ttttccctgc taggggtttt aggtctcttc ccctctcaga   2940

gctacttggg ccatagctcc tgctccacag ccatcccagc cttggcatct agagcttgat   3000

gccagtaggc tcaactaggg agtgagtgca aaaagctgag tatggtgaga gaagcctgtg   3060

ccctgatcca agtttactca accctctcag gtgaccaaaa tccccttctc atcactcccc   3120

tccaaagagg tgactgggcc ctgcctctgt ttgacaaacc tctaacccag gtcttgacac   3180

cagctgttct gtcccttgga gctgtaaacc agagagctgc tggggattct ggcctagtcc   3240

cttccacacc cccacccctt gctctcaacc caggagcatc cacctccttc tctgtctcat   3300

gtgtgctctt cttctttcta cagtattatg tactctactg atatctaaat attgatttct   3360

gccttccttg ctaatgcacc attagaagat attagtcttg gggcaggatg attttggcct   3420

cattacttta ccacccccac acctggaaag catatactat attacaaaat gacattttgc   3480

caaaattatt aatataagaa gctttcagta ttagtgatgt catctgtcac tataggtcat   3540

acaatccatt cttaaagtac ttgttatttg tttttattat tactgtttgt cttctcccca   3600

gggttcagtc ctcaaggggc catcctgtcc caccatgcag tgcccctagc ttagagcctc   3660

cctcaattcc ccctggccac caccccccac tctgtgcctg accttgagga gtcttgtgtg   3720

cattgctgtg aattagctca cttggtgata tgtcctatat tggctaaatt gaaacctgga   3780

attgtggggc aatctattaa tagctgcctt aaagtcagta acttaccctt agggaggctg   3840

ggggaaaagg ttagattttg tattcagggg ttttttgtgt actttttggg ttttttaaaa   3900

attgtttttg gaggggttta tgctcaatcc atgttctatt tcagtgccaa taaaatttag   3960

gaagacttca aaaaaaaaaa a                                             3981


<210>  100
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Pro Lys Thr Ile Ser Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln 
        35                  40                  45              


Tyr Gln Asp Thr Lys Gly Phe Ser Thr Trp Leu Lys Leu Asn Lys Lys 
    50                  55                  60                  


Val Thr Ala Gln Asp Val Arg Lys Glu Ser Pro Leu Leu Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Asn 
            100                 105                 110         


Asp Asp Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr 
        115                 120                 125             


Ala Val Gln Ser Lys Tyr Gly Asp Phe Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ala Gly Asp Lys Leu Leu Pro Gln Arg Val Leu Glu Gln 
145                 150                 155                 160 


His Lys Leu Asn Lys Asp Gln Trp Glu Glu Arg Ile Gln Val Trp His 
                165                 170                 175     


Glu Glu His Arg Gly Met Leu Arg Glu Asp Ala Val Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ser Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Ser Glu Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Gln Asn Asp Arg Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Met Glu Arg 
305                 310                 315                 320 


Ala Met Leu Glu Asn Glu Lys Lys Lys Arg Glu Met Ala Glu Lys Glu 
                325                 330                 335     


Lys Glu Lys Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys 
            340                 345                 350         


Gln Ile Glu Glu Gln Thr Lys Lys Ala Gln Gln Glu Leu Glu Glu Gln 
        355                 360                 365             


Thr Arg Arg Ala Leu Glu Leu Glu Gln Glu Arg Lys Arg Ala Gln Ser 
    370                 375                 380                 


Glu Ala Glu Lys Leu Ala Lys Glu Arg Gln Glu Ala Glu Glu Ala Lys 
385                 390                 395                 400 


Glu Ala Leu Leu Gln Ala Ser Arg Asp Gln Lys Lys Thr Gln Glu Gln 
                405                 410                 415     


Leu Ala Leu Glu Met Ala Glu Leu Thr Ala Arg Ile Ser Gln Leu Glu 
            420                 425                 430         


Met Ala Arg Gln Lys Lys Glu Ser Glu Ala Val Glu Trp Gln Gln Lys 
        435                 440                 445             


Ala Gln Met Val Gln Glu Asp Leu Glu Lys Thr Arg Ala Glu Leu Lys 
    450                 455                 460                 


Thr Ala Met Ser Thr Pro His Val Ala Glu Pro Ala Glu Asn Glu Gln 
465                 470                 475                 480 


Asp Glu Gln Asp Glu Asn Gly Ala Glu Ala Ser Ala Asp Leu Arg Ala 
                485                 490                 495     


Asp Ala Met Ala Lys Asp Arg Ser Glu Glu Glu Arg Thr Thr Glu Ala 
            500                 505                 510         


Glu Lys Asn Glu Arg Val Gln Lys His Leu Lys Ala Leu Thr Ser Glu 
        515                 520                 525             


Leu Ala Asn Ala Arg Asp Glu Ser Lys Lys Thr Ala Asn Asp Met Ile 
    530                 535                 540                 


His Ala Glu Asn Met Arg Leu Gly Arg Asp Lys Tyr Lys Thr Leu Arg 
545                 550                 555                 560 


Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ser 
                565                 570                 575     


Met 
    


<210>  101
<211>  2406
<212>  DNA
<213>  Homo sapiens

<400>  101
tctctctctg cttctttcct tttctctctc atggtagggt tatgagtcag ttgccaaaag     60

gtggggacat ttcctgatgc atttgcaaca ctgagaagtt atcttaaggg aggctgggcc    120

ccattctact catctggccc agaaagtgaa caccttgggg gccactaagg cagccctgct    180

aggggagacg ctccaacctg tcttctctct gtctcctggc agctctcttg gcctcctagt    240

ttctacctaa tcatgtccct ggtggaggcc atcagcctct ggaatgaagg ggtgctggca    300

gcggacaaga aggactggaa gggagccctg gatgccttca gtgccgtcca ggacccccac    360

tcccggattt gcttcaacat tggctgcatg tacactatcc tgaagaacat gactgaagca    420

gagaaggcct ttaccagaag cattaaccga gacaagcact tggcagtggc ttacttccaa    480

cgagggatgc tctactacca gacagagaaa tatgatttgg ctatcaaaga ccttaaagaa    540

gccttgattc agcttcgagg gaaccagctg atagactata agatcctggg gctccagttc    600

aagctgtttg cctgtgaggt gttatataac attgctttca tgtatgccaa gaaggaggaa    660

tggaaaaaag ctgaagaaca gttagcattg gccacgagca tgaagtctga gcccagacat    720

tccaaaatcg acaaggcgat ggagtgtgtc tggaagcaga agctatatga gccagtggtg    780

atccctgtgg gcaagctgtt tcgaccaaat gagagacaag tggctcagct ggccaagaag    840

gattacctag gcaaggcgac ggtcgtggca tctgtggtgg atcaagacag tttctctggg    900

tttgcccctc tgcaaccaca ggcagctgag cctccaccca gaccgaaaac cccagagatc    960

ttcagggctc tggaagggga ggctcaccgt gtgctatttg ggtttgtgcc tgagacaaaa   1020

gaagagctcc aggtcatgcc agggaacatt gtctttgtct tgaagaaggg caatgataac   1080

tgggccacgg tcatgttcaa cgggcagaag gggcttgttc cctgcaacta ccttgaacca   1140

gttgagctgc ggatccaccc tcagcagcag ccccaggagg aaagctctcc gcagtccgac   1200

atcccagctc ctcctagttc caaagcccct ggaagacccc agctgtcacc aggccagaaa   1260

caaaaagaag agcctaagga agtgaagctc agtgttccca tgccctacac actcaaggtg   1320

cactacaagt acacggtagt catgaagact cagcccgggc tcccctacag ccaggtccgg   1380

gacatggtgt ctaagaaact ggagctccgg ctggaacaca ctaagctgag ctatcggcct   1440

cgggacagca atgagctggt gcccctttca gaagacagca tgaaggatgc ctggggccag   1500

gtgaaaaact actgcctgac tctgtggtgt gagaacacag tgggtgacca aggctttcca   1560

gatgaaccca aggaaagtga aaaagctgat gctaataacc agacaacaga acctcagctt   1620

aagaaaggca gccaagtgga ggcactcttc agttatgagg ctacccaacc agaggacctg   1680

gagtttcagg aaggggatat aatcctggtg ttatcaaagg tgaatgaaga atggctggaa   1740

ggggagtgca aagggaaggt gggcattttc cccaaagttt ttgttgaaga ctgcgcaact   1800

acagatttgg aaagcactcg gagagaagtc taggatgttt cacaaactac aaagctgaag   1860

aaaatgaagc cctattactt gtttgtaaga tttagcaccc ttctgctgta tactgtactg   1920

agacattaca gtttggaagt gttaactatt tattccctgt taaaatttaa cctactagac   1980

aatgatgtga gtacccagga tgatttcctg gggcacagtg ggtgaggaga tggggacagg   2040

tgaatggagg agttagggga gaggaaaagt ggatggaagt gtctggaaag ggcacgagag   2100

agtcttccag gtactgatcc tgtttcttgc tctgagtgct agctagccag ctgtgttcac   2160

actgtaaaca ttcatcaagc tgtacatttg gtgcactttt ctgtgtcata ccacaataaa   2220

aaaaaaccta gcatcttaca aaaacaagac acccaagtcc aggcccaagg agtaagtaca   2280

aatattcctg tttctgaacc attactgtaa ttggctctta aggcttgaag taaccttata   2340

ggttactcat aaggcatata caaataaact tgtttgtttt cttttttcaa aaaaaaaaaa   2400

aaaaaa                                                              2406


<210>  102
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ser Leu Val Glu Ala Ile Ser Leu Trp Asn Glu Gly Val Leu Ala 
1               5                   10                  15      


Ala Asp Lys Lys Asp Trp Lys Gly Ala Leu Asp Ala Phe Ser Ala Val 
            20                  25                  30          


Gln Asp Pro His Ser Arg Ile Cys Phe Asn Ile Gly Cys Met Tyr Thr 
        35                  40                  45              


Ile Leu Lys Asn Met Thr Glu Ala Glu Lys Ala Phe Thr Arg Ser Ile 
    50                  55                  60                  


Asn Arg Asp Lys His Leu Ala Val Ala Tyr Phe Gln Arg Gly Met Leu 
65                  70                  75                  80  


Tyr Tyr Gln Thr Glu Lys Tyr Asp Leu Ala Ile Lys Asp Leu Lys Glu 
                85                  90                  95      


Ala Leu Ile Gln Leu Arg Gly Asn Gln Leu Ile Asp Tyr Lys Ile Leu 
            100                 105                 110         


Gly Leu Gln Phe Lys Leu Phe Ala Cys Glu Val Leu Tyr Asn Ile Ala 
        115                 120                 125             


Phe Met Tyr Ala Lys Lys Glu Glu Trp Lys Lys Ala Glu Glu Gln Leu 
    130                 135                 140                 


Ala Leu Ala Thr Ser Met Lys Ser Glu Pro Arg His Ser Lys Ile Asp 
145                 150                 155                 160 


Lys Ala Met Glu Cys Val Trp Lys Gln Lys Leu Tyr Glu Pro Val Val 
                165                 170                 175     


Ile Pro Val Gly Lys Leu Phe Arg Pro Asn Glu Arg Gln Val Ala Gln 
            180                 185                 190         


Leu Ala Lys Lys Asp Tyr Leu Gly Lys Ala Thr Val Val Ala Ser Val 
        195                 200                 205             


Val Asp Gln Asp Ser Phe Ser Gly Phe Ala Pro Leu Gln Pro Gln Ala 
    210                 215                 220                 


Ala Glu Pro Pro Pro Arg Pro Lys Thr Pro Glu Ile Phe Arg Ala Leu 
225                 230                 235                 240 


Glu Gly Glu Ala His Arg Val Leu Phe Gly Phe Val Pro Glu Thr Lys 
                245                 250                 255     


Glu Glu Leu Gln Val Met Pro Gly Asn Ile Val Phe Val Leu Lys Lys 
            260                 265                 270         


Gly Asn Asp Asn Trp Ala Thr Val Met Phe Asn Gly Gln Lys Gly Leu 
        275                 280                 285             


Val Pro Cys Asn Tyr Leu Glu Pro Val Glu Leu Arg Ile His Pro Gln 
    290                 295                 300                 


Gln Gln Pro Gln Glu Glu Ser Ser Pro Gln Ser Asp Ile Pro Ala Pro 
305                 310                 315                 320 


Pro Ser Ser Lys Ala Pro Gly Arg Pro Gln Leu Ser Pro Gly Gln Lys 
                325                 330                 335     


Gln Lys Glu Glu Pro Lys Glu Val Lys Leu Ser Val Pro Met Pro Tyr 
            340                 345                 350         


Thr Leu Lys Val His Tyr Lys Tyr Thr Val Val Met Lys Thr Gln Pro 
        355                 360                 365             


Gly Leu Pro Tyr Ser Gln Val Arg Asp Met Val Ser Lys Lys Leu Glu 
    370                 375                 380                 


Leu Arg Leu Glu His Thr Lys Leu Ser Tyr Arg Pro Arg Asp Ser Asn 
385                 390                 395                 400 


Glu Leu Val Pro Leu Ser Glu Asp Ser Met Lys Asp Ala Trp Gly Gln 
                405                 410                 415     


Val Lys Asn Tyr Cys Leu Thr Leu Trp Cys Glu Asn Thr Val Gly Asp 
            420                 425                 430         


Gln Gly Phe Pro Asp Glu Pro Lys Glu Ser Glu Lys Ala Asp Ala Asn 
        435                 440                 445             


Asn Gln Thr Thr Glu Pro Gln Leu Lys Lys Gly Ser Gln Val Glu Ala 
    450                 455                 460                 


Leu Phe Ser Tyr Glu Ala Thr Gln Pro Glu Asp Leu Glu Phe Gln Glu 
465                 470                 475                 480 


Gly Asp Ile Ile Leu Val Leu Ser Lys Val Asn Glu Glu Trp Leu Glu 
                485                 490                 495     


Gly Glu Cys Lys Gly Lys Val Gly Ile Phe Pro Lys Val Phe Val Glu 
            500                 505                 510         


Asp Cys Ala Thr Thr Asp Leu Glu Ser Thr Arg Arg Glu Val 
        515                 520                 525     


<210>  103
<211>  3316
<212>  DNA
<213>  Homo sapiens

<400>  103
gtaggggtag gagggggccg gcggagtttc cctccccgcc cagcggccct gggcgggctt     60

ttcggctgct tctcataagc aggtggtttc gtttctccgg cacaggtagg tttctctggc    120

accgattcgg ggcctgcccg gacttcgccg cacgctgcag aacctcgccc agcgcccacc    180

atgccccggc agctcagcgc ggcggccgcg ctcttcgcgt ccctggccgt aattttgcac    240

gatggcagtc aaatgagagc aaaagcattt ccagaaacca gagattattc tcaacctact    300

gcagcagcaa cagtacagga cataaaaaaa cctgtccagc aaccagctaa gcaagcacct    360

caccaaactt tagcagcaag attcatggat ggtcatatca cctttcaaac agcggccaca    420

gtaaaaattc caacaactac cccagcaact acaaaaaaca ctgcaaccac cagcccaatt    480

acctacaccc tggtcacaac ccaggccaca cccaacaact cacacacagc tcctccagtt    540

actgaagtta cagtcggccc tagcttagcc ccttattcac tgccacccac catcacccca    600

ccagctcata caactggaac cagttcatca accgtcagcc acacaactgg gaacaccact    660

caacccagta accagaccac ccttccagca actttatcga tagcactgca caaaagcaca    720

accggtcaga agcctgttca acccacccat gccccaggaa caacggcagc tgcccacaat    780

accacccgca cagctgcacc tgcctccacg gttcctgggc ccacccttgc acctcagcca    840

tcgtcagtca agactggaat ttatcaggtt ctaaacggaa gcagactctg tataaaagca    900

gagatgggga tacagctgat tgttcaagac aaggagtcgg ttttttcacc tcggagatac    960

ttcaacatcg accccaacgc aacgcaagcc tctgggaact gtggcacccg aaaatccaac   1020

cttctgttga attttcaggg cggatttgtg aatctcacat ttaccaagga tgaagaatca   1080

tattatatca gtgaagtggg agcctatttg accgtctcag atccagagac aatttaccaa   1140

ggaatcaaac atgcggtggt gatgttccag acagcagtcg ggcattcctt caagtgcgtg   1200

agtgaacaga gcctccagtt gtcagcccac ctgcaggtga aaacaaccga tgtccaactt   1260

caagcctttg attttgaaga tgaccacttt ggaaatgtgg atgagtgctc gtctgactac   1320

acaattgtgc ttcctgtgat tggggccatc gtggttggtc tctgccttat gggtatgggt   1380

gtctataaaa tccgcctaag gtgtcaatca tctggatacc agagaatcta attgttgccc   1440

ggggggaatg aaaataatgg aatttagaga actctttcat cccttccagg atggatgttg   1500

ggaaattccc tcagagtgtg ggtccttcaa acaatgtaaa ccaccatctt ctattcaaat   1560

gaagtgagtc atgtgtgatt taagttcagg cagcacatca atttctaaat actttttgtt   1620

tattttatga aagatatagt gagctgttta ttttctagtt tcctttagaa tattttagcc   1680

actcaaagtc aacatttgag atatgttgaa ttaacataat atatgtaaag tagaataagc   1740

cttcaaatta taaaccaagg gtcaattgta actaatacta ctgtgtgtgc attgaagatt   1800

ttattttacc cttgatctta acaaagcctt tgctttgtta tcaaatggac tttcagtgct   1860

tttactatct gtgttttatg gtttcatgta acatacatat tcctggtgta gcacttaact   1920

ccttttccac tttaaatttg tttttgtttt ttgagacgga gtttcactct tgtcacccag   1980

gctggagtac agtggcacga tctcggctta tggcaacctc cgcctcccgg gttcaagtga   2040

ttctcctgct tcagcttccc gagtagctgg gattacaggc acacactacc acgcctggct   2100

aatttttgta tttttattat agacggggtt tcaccatgtt ggccagactg gtcttgaact   2160

cttgacctca ggtgatccac ccacctcagc ctcccaaagt gctgggatta caggcatgag   2220

ccattgcgcc cggccttaaa tgtttttttt aatcatcaaa aagaacaaca tatctcaggt   2280

tgtctaagtg tttttatgta aaaccaacaa aaagaacaaa tcagcttata ttttttatct   2340

tgatgactcc tgctccagaa tcgctagact aagaattagg tggctacaga tggtagaact   2400

aaacaataag caagagacaa taataatggc ccttaattat taacaaagtg ccagagtcta   2460

ggctaagcac tttatctata tctcatttca ttctcacaac ttataggtga atgagtaaac   2520

tgagacttaa gggaactgaa tcacttaaat gtcacctggc taactgatgg cagagccaga   2580

gcttgaattc atgttggtct gacatcaagg tctttggtct tctccctaca ccaagttacc   2640

tacaagaaca atgacaccac actctgcctg aaggctcaca cctcatacca gcatacgctc   2700

accttacagg gaaatgggtt tatccaggat catgagacat tagggtagat gaaaggagag   2760

ctttgcagat aacaaaatag cctatcctta ataaatcctc cactctctgg aaggagactg   2820

aggggctttg taaaacatta gtcagttgct catttttatg ggattgctta gctgggctgt   2880

aaagatgaag gcatcaaata aactcaaagt atttttaaat ttttttgata atagagaaac   2940

ttcgctaacc aactgttctt tcttgagtgt atagccccat cttgtggtaa cttgctgctt   3000

ctgcacttca tatccatatt tcctattgtt cactttattc tgtagagcag cctgccaaga   3060

attttatttc tgctgttttt tttgctgcta aagaaaggaa ctaagtcagg atgttaacag   3120

aaaagtccac ataaccctag aattcttagt caaggaataa ttcaagtcag cctagagacc   3180

atgttgactt tcctcatgtg tttccttatg actcagtaag ttggcaaggt cctgacttta   3240

gtcttaataa aacattgaat tgtagtaaag gtttttgtaa taaaaactta ctttggaaaa   3300

aaaaaaaaaa aaaaaa                                                   3316


<210>  104
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Glu Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Tyr Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Ile Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Val Lys Thr Thr Asp Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Met Gly Met Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     


<210>  105
<211>  1080
<212>  DNA
<213>  Homo sapiens

<400>  105
ggagaggact ggctgggcag gggcgccgcc ccgcctcggg agaggcgggc cgggcggggc     60

tgggagtatt tgaggctcgg agccaccgcc ccgccggcgc ccgcagcacc tcctcgccag    120

cagccgtccg gagccagcca acgagcggaa aatggcagac aatttttcgc tccatgatgc    180

gttatctggg tctggaaacc caaaccctca aggatggcct ggcgcatggg ggaaccagcc    240

tgctggggca gggggctacc caggggcttc ctatcctggg gcctaccccg ggcaggcacc    300

cccaggggct tatcctggac aggcacctcc aggcgcctac cctggagcac ctggagctta    360

tcccggagca cctgcacctg gagtctaccc agggccaccc agcggccctg gggcctaccc    420

atcttctgga cagccaagtg ccaccggagc ctaccctgcc actggcccct atggcgcccc    480

tgctgggcca ctgattgtgc cttataacct gcctttgcct gggggagtgg tgcctcgcat    540

gctgataaca attctgggca cggtgaagcc caatgcaaac agaattgctt tagatttcca    600

aagagggaat gatgttgcct tccactttaa cccacgcttc aatgagaaca acaggagagt    660

cattgtttgc aatacaaagc tggataataa ctggggaagg gaagaaagac agtcggtttt    720

cccatttgaa agtgggaaac cattcaaaat acaagtactg gttgaacctg accacttcaa    780

ggttgcagtg aatgatgctc acttgttgca gtacaatcat cgggttaaaa aactcaatga    840

aatcagcaaa ctgggaattt ctggtgacat agacctcacc agtgcttcat ataccatgat    900

ataatctgaa aggggcagat taaaaaaaaa aaaagaatct aaaccttaca tgtgtaaagg    960

tttcatgttc actgtgagtg aaaattttta cattcatcaa tatccctctt gtaagtcatc   1020

tacttaataa atattacagt gaattacctg tctcaatatg tcaaaaaaaa aaaaaaaaaa   1080


<210>  106
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr His 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Pro Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


<210>  107
<211>  1057
<212>  DNA
<213>  Homo sapiens

<400>  107
gtctcagcgg ctgccaacag atcatgagcc atcagctcct ctggggccag ctataggaca     60

acagaactct caccaaagga ccagacacag tgagcaccat gggacagtgt cggtcagcca    120

acgcagagga tgctcaggaa ttcagtgatg tggagagggc cattgagacc ctcatcaaga    180

actttcacca gtactccgtg gagggtggga aggagacgct gaccccttct gagctacggg    240

acctggtcac ccagcagctg ccccatctca tgccgagcaa ctgtggcctg gaagagaaaa    300

ttgccaacct gggcagctgc aatgactcta aactggagtt caggagtttc tgggagctga    360

ttggagaagc ggccaagagt gtgaagctgg agaggcctgt ccgggggcac tgagaactcc    420

ctctggaatt cttggggggt gttggggaga gactgtgggc ctggagataa aacttgtctc    480

ctctaccacc accctgtacc ctagcctgca cctgtcctca tctctgcaaa gttcagcttc    540

cttccccagg tctctgtgca ctctgtcttg gatgctctgg ggagctcatg ggtggaggag    600

tctccaccag agggaggctc aggggactgg ttgggccagg gatgaatatt tgagggataa    660

aaattgtgta agagccaaag aattggtagt agggggagaa cagagaggag ctgggctatg    720

ggaaatgatt tgaataatgg agctgggaat atggctggat atctggtact aaaaaagggt    780

ctttaagaac ctacttccta atctcttccc caatccaaac catagctgtc tgtccagtgc    840

tctcttcctg cctccagctc tgccccaggc tcctcctaga ctctgtccct gggctagggc    900

aggggaggag ggagagcagg gttgggggag aggctgagga gagtgtgaca tgtggggaga    960

ggaccagctg ggtgcttggg cattgacaga atgatggttg ttttgtatca tttgattaat   1020

aaaaaaaaat gaaaaaagtg aaaaaaaaaa aaaaaaa                            1057


<210>  108
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Gly Gln Cys Arg Ser Ala Asn Ala Glu Asp Ala Gln Glu Phe Ser 
1               5                   10                  15      


Asp Val Glu Arg Ala Ile Glu Thr Leu Ile Lys Asn Phe His Gln Tyr 
            20                  25                  30          


Ser Val Glu Gly Gly Lys Glu Thr Leu Thr Pro Ser Glu Leu Arg Asp 
        35                  40                  45              


Leu Val Thr Gln Gln Leu Pro His Leu Met Pro Ser Asn Cys Gly Leu 
    50                  55                  60                  


Glu Glu Lys Ile Ala Asn Leu Gly Ser Cys Asn Asp Ser Lys Leu Glu 
65                  70                  75                  80  


Phe Arg Ser Phe Trp Glu Leu Ile Gly Glu Ala Ala Lys Ser Val Lys 
                85                  90                  95      


Leu Glu Arg Pro Val Arg Gly His 
            100                 


<210>  109
<211>  1973
<212>  DNA
<213>  Homo sapiens

<400>  109
gagtgagaag tcttaggagg taggaggcag gaggaactga agcccagctg tgaaggccgc     60

agactgcagt gagaggaggc tgcactccat tttgcaatgg cctcccttgc tgcagcaaat    120

gcagagtttt gcttcaacct gttcagagag atggatgaca atcaaggaaa tggaaatgtg    180

ttcttttcct ctctgagcct cttcgctgcc ctggccctgg tccgcttggg cgctcaagat    240

gactccctct ctcagattga taagttgctt catgttaaca ctgcctcagg atatggaaac    300

tcttctaata gtcagtcagg gctccagtct caactgaaaa gagttttttc tgatataaat    360

gcatcccaca aggattatga tctcagcatt gtgaatgggc tttttgctga aaaagtgtat    420

ggctttcata aggactacat tgagtgtgcc gaaaaattat acgatgccaa agtggagcga    480

gttgacttta cgaatcattt agaagacact agacgtaata ttaataagtg ggttgaaaat    540

gaaacacatg gcaaaatcaa gaacgtgatt ggtgaaggtg gcataagctc atctgctgta    600

atggtgctgg tgaatgctgt gtacttcaaa ggcaagtggc aatcagcctt caccaagagc    660

gaaaccataa attgccattt caaatctccc aagtgctctg ggaaggcagt cgccatgatg    720

catcaggaac ggaagttcaa tttgtctgtt attgaggacc catcaatgaa gattcttgag    780

ctcagataca atggtggcat aaacatgtac gttctgctgc ctgagaatga cctctctgaa    840

attgaaaaca aactgacctt tcagaatcta atggaatgga ccaatccaag gcgaatgacc    900

tctaagtatg ttgaggtatt ttttcctcag ttcaagatag agaagaatta tgaaatgaaa    960

caatatttga gagccctagg gctgaaagat atctttgatg aatccaaagc agatctctct   1020

gggattgctt cggggggtcg tctgtatata tcaaggatga tgcacaaatc ttacatagag   1080

gtcactgagg agggcaccga ggctactgct gccacaggaa gtaatattgt agaaaagcaa   1140

ctccctcagt ccacgctgtt tagagctgac cacccattcc tatttgttat caggaaggat   1200

gacatcatct tattcagtgg caaagtttct tgcccttgaa aatccaattg gtttctgtta   1260

tagcagtccc cacaacatca aagaaccacc acaagtcaat agatttgagt ttaattggaa   1320

aaatgtggtg tttcctttga gtttatttct tcctaacatt ggtcagcaga tgacactggt   1380

gacttgaccc ttcctagaca cctggttgat tgtcctgatc cctgctctta gcattctacc   1440

accatgtgtc tcacccattt ctaatttcat tgtctttctt cccacgctca tttctatcat   1500

tctcccccat gacccgtctg gaaattatgg agagtgctca actggtaagg agaacgtaga   1560

agtagcccta gggatccttt ttgaaactct acagttatcg cagatattct agcttcattg   1620

taagcaatct aggaaataag ccctgctgct ttctagaaat aagtgtgaag gataaatttt   1680

ctttgttgac ctatgaagat tttagagttt accttcatat gtttgatttt aaatcagtgt   1740

ataatctaga tggtaaaaaa tgtgaaattg ggattaggga ccaaccaaaa tatttcatta   1800

atgctttcaa ttgacaaatt ttggtctttc tttgataaga caatatgtac atagtttttt   1860

caaatattaa agatctttta actgttggca gttgttatct acagaatcat atctcatatg   1920

ctgtgtagtt tataagtttt ttctctattt atcagaataa agaaatacaa cat          1973


<210>  110
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Ala Ser Leu Ala Ala Ala Asn Ala Glu Phe Cys Phe Asn Leu Phe 
1               5                   10                  15      


Arg Glu Met Asp Asp Asn Gln Gly Asn Gly Asn Val Phe Phe Ser Ser 
            20                  25                  30          


Leu Ser Leu Phe Ala Ala Leu Ala Leu Val Arg Leu Gly Ala Gln Asp 
        35                  40                  45              


Asp Ser Leu Ser Gln Ile Asp Lys Leu Leu His Val Asn Thr Ala Ser 
    50                  55                  60                  


Gly Tyr Gly Asn Ser Ser Asn Ser Gln Ser Gly Leu Gln Ser Gln Leu 
65                  70                  75                  80  


Lys Arg Val Phe Ser Asp Ile Asn Ala Ser His Lys Asp Tyr Asp Leu 
                85                  90                  95      


Ser Ile Val Asn Gly Leu Phe Ala Glu Lys Val Tyr Gly Phe His Lys 
            100                 105                 110         


Asp Tyr Ile Glu Cys Ala Glu Lys Leu Tyr Asp Ala Lys Val Glu Arg 
        115                 120                 125             


Val Asp Phe Thr Asn His Leu Glu Asp Thr Arg Arg Asn Ile Asn Lys 
    130                 135                 140                 


Trp Val Glu Asn Glu Thr His Gly Lys Ile Lys Asn Val Ile Gly Glu 
145                 150                 155                 160 


Gly Gly Ile Ser Ser Ser Ala Val Met Val Leu Val Asn Ala Val Tyr 
                165                 170                 175     


Phe Lys Gly Lys Trp Gln Ser Ala Phe Thr Lys Ser Glu Thr Ile Asn 
            180                 185                 190         


Cys His Phe Lys Ser Pro Lys Cys Ser Gly Lys Ala Val Ala Met Met 
        195                 200                 205             


His Gln Glu Arg Lys Phe Asn Leu Ser Val Ile Glu Asp Pro Ser Met 
    210                 215                 220                 


Lys Ile Leu Glu Leu Arg Tyr Asn Gly Gly Ile Asn Met Tyr Val Leu 
225                 230                 235                 240 


Leu Pro Glu Asn Asp Leu Ser Glu Ile Glu Asn Lys Leu Thr Phe Gln 
                245                 250                 255     


Asn Leu Met Glu Trp Thr Asn Pro Arg Arg Met Thr Ser Lys Tyr Val 
            260                 265                 270         


Glu Val Phe Phe Pro Gln Phe Lys Ile Glu Lys Asn Tyr Glu Met Lys 
        275                 280                 285             


Gln Tyr Leu Arg Ala Leu Gly Leu Lys Asp Ile Phe Asp Glu Ser Lys 
    290                 295                 300                 


Ala Asp Leu Ser Gly Ile Ala Ser Gly Gly Arg Leu Tyr Ile Ser Arg 
305                 310                 315                 320 


Met Met His Lys Ser Tyr Ile Glu Val Thr Glu Glu Gly Thr Glu Ala 
                325                 330                 335     


Thr Ala Ala Thr Gly Ser Asn Ile Val Glu Lys Gln Leu Pro Gln Ser 
            340                 345                 350         


Thr Leu Phe Arg Ala Asp His Pro Phe Leu Phe Val Ile Arg Lys Asp 
        355                 360                 365             


Asp Ile Ile Leu Phe Ser Gly Lys Val Ser Cys Pro 
    370                 375                 380 


<210>  111
<211>  4987
<212>  DNA
<213>  Homo sapiens

<400>  111
gagtggagtt ctggaggaat gtttaccaga cacagagccc agagggacag cgcccagagc     60

ccagatagag agacacggcc tcactggctc agcaccaggg tccccttccc cctcctcagc    120

tccctccctg gcccctttaa gaaagagctg atcctctcct ctcttgagtt aacccctgat    180

tgtccaggtg gcccctggct ctggcctggt gggcggaggc aaagggggag ccaggggcgg    240

agaaagggtt gcccaagtct gggagtgagg gaaggaggca ggggtgctga gaaggcggct    300

gctgggcaga gccggtggca agggcctccc ctgccgctgt gccaggcagg cagtgccaaa    360

tccggggagc ctggagctgg ggggagggcc ggggacagcc cggccctgcc ccctcccccg    420

ctgggagccc agcaacttct gaggaaagtt tggcacccat ggcgtggcgg tgccccagga    480

tgggcagggt cccgctggcc tggtgcttgg cgctgtgcgg ctgggcgtgc atggccccca    540

ggggcacgca ggctgaagaa agtcccttcg tgggcaaccc agggaatatc acaggtgccc    600

ggggactcac gggcaccctt cggtgtcagc tccaggttca gggagagccc cccgaggtac    660

attggcttcg ggatggacag atcctggagc tcgcggacag cacccagacc caggtgcccc    720

tgggtgagga tgaacaggat gactggatag tggtcagcca gctcagaatc acctccctgc    780

agctttccga cacgggacag taccagtgtt tggtgtttct gggacatcag accttcgtgt    840

cccagcctgg ctatgttggg ctggagggct tgccttactt cctggaggag cccgaagaca    900

ggactgtggc cgccaacacc cccttcaacc tgagctgcca agctcaggga cccccagagc    960

ccgtggacct actctggctc caggatgctg tccccctggc cacggctcca ggtcacggcc   1020

cccagcgcag cctgcatgtt ccagggctga acaagacatc ctctttctcc tgcgaagccc   1080

ataacgccaa gggggtcacc acatcccgca cagccaccat cacagtgctc ccccagcagc   1140

cccgtaacct ccacctggtc tcccgccaac ccacggagct ggaggtggct tggactccag   1200

gcctgagcgg catctacccc ctgacccact gcaccctgca ggctgtgctg tcagacgatg   1260

ggatgggcat ccaggcggga gaaccagacc ccccagagga gcccctcacc tcgcaagcat   1320

ccgtgccccc ccatcagctt cggctaggca gcctccatcc tcacacccct tatcacatcc   1380

gcgtggcatg caccagcagc cagggcccct catcctggac ccactggctt cctgtggaga   1440

cgccggaggg agtgcccctg ggcccccctg agaacattag tgctacgcgg aatgggagcc   1500

aggccttcgt gcattggcaa gagccccggg cgcccctgca gggtaccctg ttagggtacc   1560

ggctggcgta tcaaggccag gacaccccag aggtgctaat ggacataggg ctaaggcaag   1620

aggtgaccct ggagctgcag ggggacgggt ctgtgtccaa tctgacagtg tgtgtggcag   1680

cctacactgc tgctggggat ggaccctgga gcctcccagt acccctggag gcctggcgcc   1740

cagtgaagga accttcaact cctgccttct cgtggccctg gtggtatgta ctgctaggag   1800

cagtcgtggc cgctgcctgt gtcctcatct tggctctctt ccttgtccac cggcgaaaga   1860

aggagacccg ttatggagaa gtgtttgaac caacagtgga aagaggtgaa ctggtagtca   1920

ggtaccgcgt gcgcaagtcc tacagtcgtc ggaccactga agctaccttg aacagcctgg   1980

gcatcagtga agagctgaag gagaagctgc gggatgtgat ggtggaccgg cacaaggtgg   2040

ccctggggaa gactctggga gagggagagt ttggagctgt gatggaaggc cagctcaacc   2100

aggacgactc catcctcaag gtggctgtga agacgatgaa gattgccatc tgcacgaggt   2160

cagagctgga ggatttcctg agtgaagcgg tctgcatgaa ggaatttgac catcccaacg   2220

tcatgaggct catcggtgtc tgtttccagg gttctgaacg agagagcttc ccagcacctg   2280

tggtcatctt acctttcatg aaacatggag acctacacag cttcctcctc tattcccggc   2340

tcggggacca gccagtgtac ctgcccactc agatgctagt gaagttcatg gcagacatcg   2400

ccagtggcat ggagtatctg agtaccaaga gattcataca ccgggacctg gcggccagga   2460

actgcatgct gaatgagaac atgtccgtgt gtgtggcgga cttcgggctc tccaagaaga   2520

tctacaatgg ggactactac cgccagggac gtatcgccaa gatgccagtc aagtggattg   2580

ccattgagag tctagctgac cgtgtctaca ccagcaagag cgatgtgtgg tccttcgggg   2640

tgacaatgtg ggagattgcc acaagaggcc aaaccccata tccgggcgtg gagaacagcg   2700

agatttatga ctatctgcgc cagggaaatc gcctgaagca gcctgcggac tgtctggatg   2760

gactgtatgc cttgatgtcg cggtgctggg agctaaatcc ccaggaccgg ccaagtttta   2820

cagagctgcg ggaagatttg gagaacacac tgaaggcctt gcctcctgcc caggagcctg   2880

acgaaatcct ctatgtcaac atggatgagg gtggaggtta tcctgaaccc cctggagctg   2940

caggaggagc tgacccccca acccagccag accctaagga ttcctgtagc tgcctcactg   3000

cggctgaggt ccatcctgct ggacgctatg tcctctgccc ttccacaacc cctagccccg   3060

ctcagcctgc tgataggggc tccccagcag ccccagggca ggaggatggt gcctgagaca   3120

accctccacc tggtactccc tctcaggatc caagctaagc actgccactg gggaaaactc   3180

caccttccca ctttcccacc ccacgcctta tccccacttg cagccctgtc ttcctaccta   3240

tcccacctcc atcccagaca ggtccctccc cttctctgtg cagtagcatc accttgaaag   3300

cagtagcatc accatctgta aaaggaaggg gttggattgc aatatctgaa gccctcccag   3360

gtgttaacat tccaagactc tagagtccaa ggtttaaaga gtctagattc aaaggttcta   3420

ggtttcaaag atgctgtgag tctttggttc taaggacctg aaattccaaa gtctctaatt   3480

ctattaaagt gctaaggttc taaggcctac tttttttttt tttttttttt tttttttttt   3540

ttttgcgata gagtctcact gtgtcaccca ggctggagtg cagtggtgca atctcgcctc   3600

actgcaacct tcacctaccg agttcaagtg attttcctgc cttggcctcc caagtagctg   3660

ggattacagg tgtgtgccac cacacccggc taatttttat atttttagta gagacagggt   3720

ttcaccatgt tggccaggct ggtctaaaac tcctgacctc aagtgatctg cccacctcag   3780

cctcccaaag tgctgagatt acaggcatga gccactgcac tcaaccttaa gacctactgt   3840

tctaaagctc tgacattatg tggttttaga ttttctggtt ctaacatttt tgataaagcc   3900

tcaaggtttt aggttctaaa gttctaagat tctgatttta ggagctaagg ctctatgagt   3960

ctagatgttt attcttctag agttcagagt ccttaaaatg taagattata gattctaaag   4020

attctatagt tctagacatg gaggttctaa ggcctaggat tctaaaatgt gatgttctaa   4080

ggctctgaga gtctagattc tctggctgta aggctctaga tcataaggct tcaaaatgtt   4140

atcttctcaa gttctaagat tctaatgatg atcaattata gtttctgagg ctttatgata   4200

atagattctc ttgtataaga tcctagatcc taagggtcga aagctctaga atctgcaatt   4260

caaaagttcc aagagtctaa agatggagtt tctaaggtcc ggtgttctaa gatgtgatat   4320

tctaagactt actctaagat cttagattct ctgtgtctaa gattctagat cagatgctcc   4380

aagattctag atgattaaat aagattctaa cggtctgttc tgtttcaagg cactctagat   4440

tccattggtc caagattccg gatcctaagc atctaagtta taagactctc acactcagtt   4500

gtgactaact agacaccaaa gttctaataa tttctaatgt tggacacctt taggttcttt   4560

gctgcattct gcctctctag gaccatggtt aagagtccaa gaatccacat ttctaaaatc   4620

ttatagttct aggcactgta gttctaagac tcaaatgttc taagtttcta agattctaaa   4680

ggtccacagg tctagactat taggtgcaat ttcaaggttc taaccctata ctgtagtatt   4740

ctttggggtg cccctctcct tcttagctat cattgcttcc tcctccccaa ctgtgggggt   4800

gtgccccctt caagcctgtg caatgcatta gggatgcctc ctttcccgca ggggatggac   4860

gatctcccac ctttcgggcc atgttgcccc cgtgagccaa tccctcacct tctgagtaca   4920

gagtgtggac tctggtgcct ccagaggggc tcaggtcaca taaaactttg tatatcaacg   4980

aaaaaaa                                                             4987


<210>  112
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro 
            420                 425                 430         


Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala 
        435                 440                 445             


Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His 
    450                 455                 460                 


Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val 
465                 470                 475                 480 


Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser 
                485                 490                 495     


Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu 
            500                 505                 510         


Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala 
        515                 520                 525             


Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly 
    530                 535                 540                 


Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met 
545                 550                 555                 560 


Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu 
                565                 570                 575     


Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile 
            580                 585                 590         


Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val 
        595                 600                 605             


Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu 
    610                 615                 620                 


Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu 
625                 630                 635                 640 


Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr 
                645                 650                 655     


Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn 
            660                 665                 670         


Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile 
        675                 680                 685             


Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val 
    690                 695                 700                 


Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys 
705                 710                 715                 720 


Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg 
                725                 730                 735     


Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr 
            740                 745                 750         


Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly 
        755                 760                 765             


Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg 
    770                 775                 780                 


Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala 
785                 790                 795                 800 


Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp 
                805                 810                 815     


Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp 
            820                 825                 830         


Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala 
        835                 840                 845             


Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr 
    850                 855                 860                 


Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly 
865                 870                 875                 880 


Gln Glu Asp Gly Ala 
                885 


<210>  113
<211>  1570
<212>  DNA
<213>  Homo sapiens

<400>  113
gccccaggga gcagtgggtg gttataactc aggcccggtg cccagagccc aggaggaggc     60

agtggccagg aaggcacagg cctgagaagt ctgcggctga gctgggagca aatcccccac    120

cccctacctg ggggacaggg caagtgagac ctggtgaggg tggctcagca ggcagggaag    180

gagaggtgtc tgtgcgtcct gcacccacat ctttctctgt cccctccttg ccctgtctgg    240

aggctgctag actcctatct tctgaattct atagtgcctg ggtctcagcg cagtgccgat    300

ggtggcccgt ccttgtggtt cctctctacc tggggaaata aggtgcagcg gccatggcta    360

cagcaagacc cccctggatg tgggtgctct gtgctctgat cacagccttg cttctggggg    420

tcacagagca tgttctcgcc aacaatgatg tttcctgtga ccacccctct aacaccgtgc    480

cctctgggag caaccaggac ctgggagctg gggccgggga agacgcccgg tcggatgaca    540

gcagcagccg catcatcaat ggatccgact gcgatatgca cacccagccg tggcaggccg    600

cgctgttgct aaggcccaac cagctctact gcggggcggt gttggtgcat ccacagtggc    660

tgctcacggc cgcccactgc aggaagaaag ttttcagagt ccgtctcggc cactactccc    720

tgtcaccagt ttatgaatct gggcagcaga tgttccaggg ggtcaaatcc atcccccacc    780

ctggctactc ccaccctggc cactctaacg acctcatgct catcaaactg aacagaagaa    840

ttcgtcccac taaagatgtc agacccatca acgtctcctc tcattgtccc tctgctggga    900

caaagtgctt ggtgtctggc tgggggacaa ccaagagccc ccaagtgcac ttccctaagg    960

tcctccagtg cttgaatatc agcgtgctaa gtcagaaaag gtgcgaggat gcttacccga   1020

gacagataga tgacaccatg ttctgcgccg gtgacaaagc aggtagagac tcctgccagg   1080

gtgattctgg ggggcctgtg gtctgcaatg gctccctgca gggactcgtg tcctggggag   1140

attacccttg tgcccggccc aacagaccgg gtgtctacac gaacctctgc aagttcacca   1200

agtggatcca ggaaaccatc caggccaact cctgagtcat cccaggactc agcacaccgg   1260

catccccacc tgctgcaggg acagccctga cactcctttc agaccctcat tccttcccag   1320

agatgttgag aatgttcatc tctccagccc ctgaccccat gtctcctgga ctcagggtct   1380

gcttccccca cattgggctg accgtgtctc tctagttgaa ccctgggaac aatttccaaa   1440

actgtccagg gcgggggttg cgtctcaatc tccctggggc actttcatcc tcaagctcag   1500

ggcccatccc ttctctgcag ctctgaccca aatttagtcc cagaaataaa ctgagaagtg   1560

gaaaaaaaaa                                                          1570


<210>  114
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile 
1               5                   10                  15      


Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp 
            20                  25                  30          


Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln 
        35                  40                  45              


Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser 
    50                  55                  60                  


Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp 
65                  70                  75                  80  


Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val 
                85                  90                  95      


Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys 
            100                 105                 110         


Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu 
        115                 120                 125             


Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly 
    130                 135                 140                 


Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn 
145                 150                 155                 160 


Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser 
                165                 170                 175     


His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr 
            180                 185                 190         


Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn 
        195                 200                 205             


Ile Ser Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln 
    210                 215                 220                 


Ile Asp Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser 
225                 230                 235                 240 


Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln 
                245                 250                 255     


Gly Leu Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro 
            260                 265                 270         


Gly Val Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr 
        275                 280                 285             


Ile Gln Ala Asn Ser 
    290             


<210>  115
<211>  1454
<212>  DNA
<213>  Homo sapiens

<400>  115
ccactcggcc ggcagcggag ccgcagccac cagccgcccg cgccctccag ccccgtccgg     60

gagtccccgg cccgctgcgg tgcctggctg agaactgtgt cttcctggag actaggctgg    120

cattttgact ttggggttgc tgaaaagcca ggagtcaaaa tgactgagcg ctttgactgc    180

caccattgca acgaatctct ctttggcaag aagtacatcc tgcgggagga gagcccctac    240

tgcgtggtgt gctttgagac cctgttcgcc aacacctgcg aggagtgtgg gaagcccatc    300

ggctgtgact gcaaggactt gtcttacaag gaccggcact ggcatgaagc ctgtttccac    360

tgctcgcagt gcagaaactc actggtggac aagccctttg ctgccaagga ggaccagctg    420

ctctgtacag actgctattc caacgagtac tcatccaagt gccaggaatg caagaagacc    480

atcatgccag gtacccgcaa gatggagtac aagggcagca gctggcatga gacctgcttc    540

atctgccacc gctgccagca gccaattgga accaagagtt tcatccccaa agacaatcag    600

aatttctgtg tgccctgcta tgagaaacaa catgccatgc agtgcgttca gtgcaaaaag    660

cccatcacca cgggaggggt cacttaccgg gagcagccct ggcacaagga gtgcttcgtg    720

tgcaccgcct gcaggaagca gctgtctggg cagcgcttca cagctcgcga tgactttgcc    780

tactgcctga actgcttctg tgacttgtat gccaagaagt gtgctgggtg caccaacccc    840

atcagcggac ttggtggcac aaaatacatc tcctttgagg aacggcagtg gcataacgac    900

tgctttaact gtaagaagtg ctccctctca ctggtggggc gtggcttcct cacagagagg    960

gacgacatcc tgtgccccga ctgtgggaaa gacatctgaa ttcaacacag agaagttgct   1020

gcttgtgatc tcacacacag atttttatgt tttctttctc acccaggcaa tcttgccttc   1080

tggtttcttc cagccacatt gagactttct tctagtgctt ttcagtgata ctcacgtttg   1140

cttaaaccct ttagtgcttt gtgatagttc agtcccaggg aaagagaaaa ctcgccctag   1200

gccctaggtg ggaagatggt ttgaaatttt tgtaatcgag taaggcacac ccaaatgtaa   1260

aaatcctttt gaatgatgcc tttataaatc tttctctcac tgtctattta agtgcaatta   1320

acatatgtca cgaacttgaa agttttctaa actcaataag gtaatgacca gttgttattt   1380

acagctctgt aacctcccgt tgcgtcaagt ctaaaccaag attatgtgac ttgcaataaa   1440

gttattcaga acag                                                     1454


<210>  116
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Thr Glu Arg Phe Asp Cys His His Cys Asn Glu Ser Leu Phe Gly 
1               5                   10                  15      


Lys Lys Tyr Ile Leu Arg Glu Glu Ser Pro Tyr Cys Val Val Cys Phe 
            20                  25                  30          


Glu Thr Leu Phe Ala Asn Thr Cys Glu Glu Cys Gly Lys Pro Ile Gly 
        35                  40                  45              


Cys Asp Cys Lys Asp Leu Ser Tyr Lys Asp Arg His Trp His Glu Ala 
    50                  55                  60                  


Cys Phe His Cys Ser Gln Cys Arg Asn Ser Leu Val Asp Lys Pro Phe 
65                  70                  75                  80  


Ala Ala Lys Glu Asp Gln Leu Leu Cys Thr Asp Cys Tyr Ser Asn Glu 
                85                  90                  95      


Tyr Ser Ser Lys Cys Gln Glu Cys Lys Lys Thr Ile Met Pro Gly Thr 
            100                 105                 110         


Arg Lys Met Glu Tyr Lys Gly Ser Ser Trp His Glu Thr Cys Phe Ile 
        115                 120                 125             


Cys His Arg Cys Gln Gln Pro Ile Gly Thr Lys Ser Phe Ile Pro Lys 
    130                 135                 140                 


Asp Asn Gln Asn Phe Cys Val Pro Cys Tyr Glu Lys Gln His Ala Met 
145                 150                 155                 160 


Gln Cys Val Gln Cys Lys Lys Pro Ile Thr Thr Gly Gly Val Thr Tyr 
                165                 170                 175     


Arg Glu Gln Pro Trp His Lys Glu Cys Phe Val Cys Thr Ala Cys Arg 
            180                 185                 190         


Lys Gln Leu Ser Gly Gln Arg Phe Thr Ala Arg Asp Asp Phe Ala Tyr 
        195                 200                 205             


Cys Leu Asn Cys Phe Cys Asp Leu Tyr Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Thr Asn Pro Ile Ser Gly Leu Gly Gly Thr Lys Tyr Ile Ser Phe Glu 
225                 230                 235                 240 


Glu Arg Gln Trp His Asn Asp Cys Phe Asn Cys Lys Lys Cys Ser Leu 
                245                 250                 255     


Ser Leu Val Gly Arg Gly Phe Leu Thr Glu Arg Asp Asp Ile Leu Cys 
            260                 265                 270         


Pro Asp Cys Gly Lys Asp Ile 
        275                 


<210>  117
<211>  2819
<212>  DNA
<213>  Homo sapiens

<400>  117
gctgcggagg gtgcgtgcgg gccgcggcag ccgaacaaag gagcaggggc gccgccgcag     60

ggacccgcca cccacctccc ggggccgcgc agcggcctct cgtctactgc caccatgacc    120

gccaacggca cagccgaggc ggtgcagatc cagttcggcc tcatcaactg cggcaacaag    180

tacctgacgg ccgaggcgtt cgggttcaag gtgaacgcgt ccgccagcag cctgaagaag    240

aagcagatct ggacgctgga gcagccccct gacgaggcgg gcagcgcggc cgtgtgcctg    300

cgcagccacc tgggccgcta cctggcggcg gacaaggacg gcaacgtgac ctgcgagcgc    360

gaggtgcccg gtcccgactg ccgtttcctc atcgtggcgc acgacgacgg tcgctggtcg    420

ctgcagtccg aggcgcaccg gcgctacttc ggcggcaccg aggaccgcct gtcctgcttc    480

gcgcagacgg tgtcccccgc cgagaagtgg agcgtgcaca tcgccatgca ccctcaggtc    540

aacatctaca gcgtcacccg taagcgctac gcgcacctga gcgcgcggcc ggccgacgag    600

atcgccgtgg accgcgacgt gccctggggc gtcgactcgc tcatcaccct cgccttccag    660

gaccagcgct acagcgtgca gaccgccgac caccgcttcc tgcgccacga cgggcgcctg    720

gtggcgcgcc ccgagccggc cactggctac acgctggagt tccgctccgg caaggtggcc    780

ttccgcgact gcgagggccg ttacctggcg ccgtcggggc ccagcggcac gctcaaggcg    840

ggcaaggcca ccaaggtggg caaggacgag ctctttgctc tggagcagag ctgcgcccag    900

gtcgtgctgc aggcggccaa cgagaggaac gtgtccacgc gccagggtat ggacctgtct    960

gccaatcagg acgaggagac cgaccaggag accttccagc tggagatcga ccgcgacacc   1020

aaaaagtgtg ccttccgtac ccacacgggc aagtactgga cgctgacggc caccgggggc   1080

gtgcagtcca ccgcctccag caagaatgcc agctgctact ttgacatcga gtggcgtgac   1140

cggcgcatca cactgagggc gtccaatggc aagtttgtga cctccaagaa gaatgggcag   1200

ctggccgcct cggtggagac agcaggggac tcagagctct tcctcatgaa gctcatcaac   1260

cgccccatca tcgtgttccg cggggagcat ggcttcatcg gctgccgcaa ggtcacgggc   1320

accctggacg ccaaccgctc cagctatgac gtcttccagc tggagttcaa cgatggcgcc   1380

tacaacatca aagactccac aggcaaatac tggacggtgg gcagtgactc cgcggtcacc   1440

agcagcggcg acactcctgt ggacttcttc ttcgagttct gcgactataa caaggtggcc   1500

atcaaggtgg gcgggcgcta cctgaagggc gaccacgcag gcgtcctgaa ggcctcggcg   1560

gaaaccgtgg accccgcctc gctctgggag tactagggcc ggcccgtcct tccccgcccc   1620

tgcccacatg gcggctcctg ccaaccctcc ctgctaaccc cttctccgcc aggtgggctc   1680

cagggcggga ggcaagcccc cttgcctttc aaactggaaa ccccagagaa aacggtgccc   1740

ccacctgtcg cccctatgga ctccccactc tcccctccgc ccgggttccc tactcccctc   1800

gggtcagcgg ctgcggcctg gccctgggag ggatttcaga tgcccctgcc ctcttgtctg   1860

ccacggggcg agtctggcac ctctttcttc tgacctcaga cggctctgag ccttatttct   1920

ctggaagcgg ctaagggacg gttgggggct gggagccctg ggcgtgtagt gtaactggaa   1980

tcttttgcct ctcccagcca cctcctccca gccccccagg agagctgggc acatgtccca   2040

agcctgtcag tggccctccc tggtgcactg tccccgaaac ccctgcttgg gaagggaagc   2100

tgtcgggtgg gctaggactg acccttgtgg tgtttttttg ggtggtggct ggaaacagcc   2160

cctctcccac gtggcagagg ctcagcctgg ctcccttccc tggagcggca gggcgtgacg   2220

gccacagggt ctgcccgctg cacgttctgc caaggtggtg gtggcgggcg ggtaggggtg   2280

tgggggccgt cttcctcctg tctctttcct ttcaccctag cctgactgga agcagaaaat   2340

gaccaaatca gtattttttt taatgaaata ttattgctgg aggcgtccca ggcaagcctg   2400

gctgtagtag cgagtgatct ggcggggggc gtctcagcac cctccccagg gggtgcatct   2460

cagccccctc tttccgtcct tcccgtccag ccccagccct gggcctgggc tgccgacacc   2520

tgggccagag cccctgctgt gattggtgct ccctgggcct cccgggtgga tgaagccagg   2580

cgtcgccccc tccgggagcc ctggggtgag ccgccggggc ccccctgctg ccagcctccc   2640

ccgtccccaa catgcatctc actctgggtg tcttggtctt ttattttttg taagtgtcat   2700

ttgtataact ctaaacgccc atgatagtag cttcaaactg gaaatagcga aataaaataa   2760

ctcagtctgc agccccaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa    2819


<210>  118
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Thr Ala Asn Gly Thr Ala Glu Ala Val Gln Ile Gln Phe Gly Leu 
1               5                   10                  15      


Ile Asn Cys Gly Asn Lys Tyr Leu Thr Ala Glu Ala Phe Gly Phe Lys 
            20                  25                  30          


Val Asn Ala Ser Ala Ser Ser Leu Lys Lys Lys Gln Ile Trp Thr Leu 
        35                  40                  45              


Glu Gln Pro Pro Asp Glu Ala Gly Ser Ala Ala Val Cys Leu Arg Ser 
    50                  55                  60                  


His Leu Gly Arg Tyr Leu Ala Ala Asp Lys Asp Gly Asn Val Thr Cys 
65                  70                  75                  80  


Glu Arg Glu Val Pro Gly Pro Asp Cys Arg Phe Leu Ile Val Ala His 
                85                  90                  95      


Asp Asp Gly Arg Trp Ser Leu Gln Ser Glu Ala His Arg Arg Tyr Phe 
            100                 105                 110         


Gly Gly Thr Glu Asp Arg Leu Ser Cys Phe Ala Gln Thr Val Ser Pro 
        115                 120                 125             


Ala Glu Lys Trp Ser Val His Ile Ala Met His Pro Gln Val Asn Ile 
    130                 135                 140                 


Tyr Ser Val Thr Arg Lys Arg Tyr Ala His Leu Ser Ala Arg Pro Ala 
145                 150                 155                 160 


Asp Glu Ile Ala Val Asp Arg Asp Val Pro Trp Gly Val Asp Ser Leu 
                165                 170                 175     


Ile Thr Leu Ala Phe Gln Asp Gln Arg Tyr Ser Val Gln Thr Ala Asp 
            180                 185                 190         


His Arg Phe Leu Arg His Asp Gly Arg Leu Val Ala Arg Pro Glu Pro 
        195                 200                 205             


Ala Thr Gly Tyr Thr Leu Glu Phe Arg Ser Gly Lys Val Ala Phe Arg 
    210                 215                 220                 


Asp Cys Glu Gly Arg Tyr Leu Ala Pro Ser Gly Pro Ser Gly Thr Leu 
225                 230                 235                 240 


Lys Ala Gly Lys Ala Thr Lys Val Gly Lys Asp Glu Leu Phe Ala Leu 
                245                 250                 255     


Glu Gln Ser Cys Ala Gln Val Val Leu Gln Ala Ala Asn Glu Arg Asn 
            260                 265                 270         


Val Ser Thr Arg Gln Gly Met Asp Leu Ser Ala Asn Gln Asp Glu Glu 
        275                 280                 285             


Thr Asp Gln Glu Thr Phe Gln Leu Glu Ile Asp Arg Asp Thr Lys Lys 
    290                 295                 300                 


Cys Ala Phe Arg Thr His Thr Gly Lys Tyr Trp Thr Leu Thr Ala Thr 
305                 310                 315                 320 


Gly Gly Val Gln Ser Thr Ala Ser Ser Lys Asn Ala Ser Cys Tyr Phe 
                325                 330                 335     


Asp Ile Glu Trp Arg Asp Arg Arg Ile Thr Leu Arg Ala Ser Asn Gly 
            340                 345                 350         


Lys Phe Val Thr Ser Lys Lys Asn Gly Gln Leu Ala Ala Ser Val Glu 
        355                 360                 365             


Thr Ala Gly Asp Ser Glu Leu Phe Leu Met Lys Leu Ile Asn Arg Pro 
    370                 375                 380                 


Ile Ile Val Phe Arg Gly Glu His Gly Phe Ile Gly Cys Arg Lys Val 
385                 390                 395                 400 


Thr Gly Thr Leu Asp Ala Asn Arg Ser Ser Tyr Asp Val Phe Gln Leu 
                405                 410                 415     


Glu Phe Asn Asp Gly Ala Tyr Asn Ile Lys Asp Ser Thr Gly Lys Tyr 
            420                 425                 430         


Trp Thr Val Gly Ser Asp Ser Ala Val Thr Ser Ser Gly Asp Thr Pro 
        435                 440                 445             


Val Asp Phe Phe Phe Glu Phe Cys Asp Tyr Asn Lys Val Ala Ile Lys 
    450                 455                 460                 


Val Gly Gly Arg Tyr Leu Lys Gly Asp His Ala Gly Val Leu Lys Ala 
465                 470                 475                 480 


Ser Ala Glu Thr Val Asp Pro Ala Ser Leu Trp Glu Tyr 
                485                 490             


<210>  119
<211>  2561
<212>  DNA
<213>  Homo sapiens

<400>  119
attcatatca tttttcttct ccggccccat ggaggaagtg agaaagttgg cacagtcacg     60

ccgggcttcg caggaccagg tcactcagtg acagatggac aatgcaagaa tgaactcctt    120

cctggaatac cccatactta gcagtggcga ctcggggacc tgctcagccc gagcctaccc    180

ctcggaccat aggattacaa ctttccagtc gtgcgcggtc agcgccaaca gttgcggcgg    240

cgacgaccgc ttcctagtgg gcaggggggt gcagatcggt tcgccccacc accaccacca    300

ccaccaccat caccaccccc agccggctac ctaccagact tccgggaacc tgggggtgtc    360

ctactcccac tcaagttgtg gtccaagcta tggctcacag aacttcagtg cgccttacag    420

cccctacgcg ttaaatcagg aagcagacgt aagtggtggg tacccccagt gcgctcccgc    480

tgtttactct ggaaatctct catctcccat ggtccagcat caccaccacc accagggtta    540

tgctgggggc gcggtgggct cgcctcaata cattcaccac tcatatggac aggagcacca    600

gagcctggcc ctggctacgt ataataactc cttgtcccct ctccacgcca gccaccaaga    660

agcctgtcgc tcccccgcat cggagacatc ttctccagcg cagacttttg actggatgaa    720

agtcaaaaga aaccctccca aaacagggaa agttggagag tacggctacc tgggtcaacc    780

caacgcggtg cgcaccaact tcactaccaa gcagctcacg gaactggaga aggagttcca    840

cttcaacaag tacctgacgc gcgcccgcag ggtggagatc gctgcatccc tgcagctcaa    900

cgagacccaa gtgaagatct ggttccagaa ccgccgaatg aagcaaaaga aacgtgagaa    960

ggagggtctc ttgcccatct ctccggccac cccgccagga aacgacgaga aggccgagga   1020

atcctcagag aagtccagct cttcgccctg cgttccttcc ccggggtctt ctacctcaga   1080

cactctgact acctcccact gaggcggctc cagccccaga caacagccca ggcatctcct   1140

tgggctggga cttcttaccc aaagcacatg cttagcttat ctttctttcc atttacagtc   1200

tctttcttcc tttctaatcc tatctgggga gctcctggcc aggataatat atttgcagat   1260

aattctggac cagagacttg gtgcggggtt aacaccttca tccagattgg gtgccagcat   1320

acattttctg gtgggcctta acatccctcc tgcttttagg agaattcaca gaacctactg   1380

ttcctttcag atgacctttt ggaaaatagt tccctttgcc aacagaaaca tgccagaagg   1440

aatcttctca tcttttatct aactatatgt acagctctcc cctcccttgt ccttgaaagt   1500

aggatatagc gaaaggcgag tccaggagct caggaagaag agatgcacta tatgtttaca   1560

caattaattc atcccttaat ttaagtcatt ttcatgtgtg tgagtttgct ggttgtaaat   1620

actttgtcct aagagattta tctttataca gattttctag aaatgtttag gttactaaaa   1680

cagggtgggc aaactctcta aactggtaca attttatagg tgaaagaaaa aattccctca   1740

tttaaaccca atcagatgcc tcagagggta gccttgattt gttcttacag ttaagaagcc   1800

ctgcagagca caaacttcag aaacccggct tcctgtgcta agtctttccc aatctctacc   1860

cctttcttct cgggccaccc tctgtttaaa atttgtgctg ggttattcag aacctaaaag   1920

tattattcaa accaatttct tccttccaca gttatcttag ctggatataa tgtattttca   1980

gctcaattgt taatgtgatg gatggcacaa tgaatgtata ttttgtgtta ttcgtgaata   2040

gtcttttgca tgtcgcacaa tgtttgatgt ccccaaagta ccacactgag ttctatcagt   2100

tatcctttgt gagcctatga tattccccat ttcctgtaca atcatgaaca gctctgagat   2160

cctggagtga tatgatccag agcagagttt acgggtctta ggatgtctgt aataaataaa   2220

tatactcaag tttcaggtat gcttaagcat ccgtgtattt ggctgggcta caatttgtta   2280

attcctatga agttggcaca tttcatgagg ggaaagggag aagggtggta aatattttca   2340

aagagatggg ccttttcttg aataaaagtt aataacagct cctttattat aatcaaagct   2400

cataatggaa aaaaagactg atgaagaaat ttatgaagca gatttatttt tgaaacaaac   2460

atggatactt cctgggtcaa gtgctaacct tttcacctcc aactggatgt tgacgtatat   2520

ataaacagaa ctcccttcaa aagccaaaaa aaaaaaaaaa a                       2561


<210>  120
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Asp Asn Ala Arg Met Asn Ser Phe Leu Glu Tyr Pro Ile Leu Ser 
1               5                   10                  15      


Ser Gly Asp Ser Gly Thr Cys Ser Ala Arg Ala Tyr Pro Ser Asp His 
            20                  25                  30          


Arg Ile Thr Thr Phe Gln Ser Cys Ala Val Ser Ala Asn Ser Cys Gly 
        35                  40                  45              


Gly Asp Asp Arg Phe Leu Val Gly Arg Gly Val Gln Ile Gly Ser Pro 
    50                  55                  60                  


His His His His His His His His His His Pro Gln Pro Ala Thr Tyr 
65                  70                  75                  80  


Gln Thr Ser Gly Asn Leu Gly Val Ser Tyr Ser His Ser Ser Cys Gly 
                85                  90                  95      


Pro Ser Tyr Gly Ser Gln Asn Phe Ser Ala Pro Tyr Ser Pro Tyr Ala 
            100                 105                 110         


Leu Asn Gln Glu Ala Asp Val Ser Gly Gly Tyr Pro Gln Cys Ala Pro 
        115                 120                 125             


Ala Val Tyr Ser Gly Asn Leu Ser Ser Pro Met Val Gln His His His 
    130                 135                 140                 


His His Gln Gly Tyr Ala Gly Gly Ala Val Gly Ser Pro Gln Tyr Ile 
145                 150                 155                 160 


His His Ser Tyr Gly Gln Glu His Gln Ser Leu Ala Leu Ala Thr Tyr 
                165                 170                 175     


Asn Asn Ser Leu Ser Pro Leu His Ala Ser His Gln Glu Ala Cys Arg 
            180                 185                 190         


Ser Pro Ala Ser Glu Thr Ser Ser Pro Ala Gln Thr Phe Asp Trp Met 
        195                 200                 205             


Lys Val Lys Arg Asn Pro Pro Lys Thr Gly Lys Val Gly Glu Tyr Gly 
    210                 215                 220                 


Tyr Leu Gly Gln Pro Asn Ala Val Arg Thr Asn Phe Thr Thr Lys Gln 
225                 230                 235                 240 


Leu Thr Glu Leu Glu Lys Glu Phe His Phe Asn Lys Tyr Leu Thr Arg 
                245                 250                 255     


Ala Arg Arg Val Glu Ile Ala Ala Ser Leu Gln Leu Asn Glu Thr Gln 
            260                 265                 270         


Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Gln Lys Lys Arg Glu 
        275                 280                 285             


Lys Glu Gly Leu Leu Pro Ile Ser Pro Ala Thr Pro Pro Gly Asn Asp 
    290                 295                 300                 


Glu Lys Ala Glu Glu Ser Ser Glu Lys Ser Ser Ser Ser Pro Cys Val 
305                 310                 315                 320 


Pro Ser Pro Gly Ser Ser Thr Ser Asp Thr Leu Thr Thr Ser His 
                325                 330                 335 


<210>  121
<211>  1575
<212>  DNA
<213>  Homo sapiens

<400>  121
tcccttctga ggaaacgaaa ccaacagcag tccaagctca gtcagcagaa gagataaaag     60

caaacaggtc tgggaggcag ttctgttgcc actctctctc ctgtcaatga tggatctcag    120

aaatacccca gccaaatctc tggacaagtt cattgaagac tatctcttgc cagacacgtg    180

tttccgcatg caaatcaacc atgccattga catcatctgt gggttcctga aggaaaggtg    240

cttccgaggt agctcctacc ctgtgtgtgt gtccaaggtg gtaaagggtg gctcctcagg    300

caagggcacc accctcagag gccgatctga cgctgacctg gttgtcttcc tcagtcctct    360

caccactttt caggatcagt taaatcgccg gggagagttc atccaggaaa ttaggagaca    420

gctggaagcc tgtcaaagag agagagcatt ttccgtgaag tttgaggtcc aggctccacg    480

ctggggcaac ccccgtgcgc tcagcttcgt actgagttcg ctccagctcg gggagggggt    540

ggagttcgat gtgctgcctg cctttgatgc cctgggtcag ttgactggcg gctataaacc    600

taacccccaa atctatgtca agctcatcga ggagtgcacc gacctgcaga aagagggcga    660

gttctccacc tgcttcacag aactacagag agacttcctg aagcagcgcc ccaccaagct    720

caagagcctc atccgcctag tcaagcactg gtaccaaaat tgtaagaaga agcttgggaa    780

gctgccacct cagtatgccc tggagctcct gacggtctat gcttgggagc gagggagcat    840

gaaaacacat ttcaacacag cccagggatt tcggacggtc ttggaattag tcataaacta    900

ccagcaactc tgcatctact ggacaaagta ttatgacttt aaaaacccca ttattgaaaa    960

gtacctgaga aggcagctca cgaaacccag gcctgtgatc ctggacccgg cggaccctac   1020

aggaaacttg ggtggtggag acccaaaggg ttggaggcag ctggcacaag aggctgaggc   1080

ctggctgaat tacccatgct ttaagaattg ggatgggtcc ccagtgagct cctggattct   1140

gctgacccag cacactccag gcagcatcca ccccacaggc agaagaggac tggacctgca   1200

ccatcctctg aatgccagtg catcttgggg gaaagggctc cagtgttatc tggaccagtt   1260

ccttcatttt caggtgggac tcttgatcca gagaggacaa agctcctcag tgagctggtg   1320

tataatccag gacagaaccc aggtctcctg actcctggcc ttctatgccc tctatcctat   1380

catagataac attctccaca gcctcacttc attccaccta ttctctgaaa atattccctg   1440

agagagaaca gagagattta gataagagaa tgaaattcca gccttgactt tcttctgtgc   1500

acctgatggg agggtaatgt ctaatgtatt atcaataaca ataaaaataa agcaaatacc   1560

atttaaaaaa aaaaa                                                    1575


<210>  122
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile 
1               5                   10                  15      


Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His 
            20                  25                  30          


Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly 
        35                  40                  45              


Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser 
    50                  55                  60                  


Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val 
65                  70                  75                  80  


Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly 
                85                  90                  95      


Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu 
            100                 105                 110         


Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn 
        115                 120                 125             


Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly 
    130                 135                 140                 


Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr 
145                 150                 155                 160 


Gly Gly Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu 
                165                 170                 175     


Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu 
            180                 185                 190         


Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu 
        195                 200                 205             


Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly 
    210                 215                 220                 


Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp 
225                 230                 235                 240 


Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg 
                245                 250                 255     


Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp 
            260                 265                 270         


Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg 
        275                 280                 285             


Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro 
    290                 295                 300                 


Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala 
305                 310                 315                 320 


Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp 
                325                 330                 335     


Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Thr Gln His Thr Pro Gly 
            340                 345                 350         


Ser Ile His Pro Thr Gly Arg Arg Gly Leu Asp Leu His His Pro Leu 
        355                 360                 365             


Asn Ala Ser Ala Ser Trp Gly Lys Gly Leu Gln Cys Tyr Leu Asp Gln 
    370                 375                 380                 


Phe Leu His Phe Gln Val Gly Leu Leu Ile Gln Arg Gly Gln Ser Ser 
385                 390                 395                 400 


Ser Val Ser Trp Cys Ile Ile Gln Asp Arg Thr Gln Val Ser 
                405                 410                 


<210>  123
<211>  1815
<212>  DNA
<213>  Homo sapiens

<400>  123
gcagagctct gtgctccctg cagtcaggac tctgggaccg cagggggctc ccggaccctg     60

actctgcagc cgaaccggca cggtttcgtg gggacccagg cttgcaaagt gacggtcatt    120

ttctctttct ttctccctct tgagtccttc tgagatgatg gctctgggcg cagcgggagc    180

tacccgggtc tttgtcgcga tggtagcggc ggctctcggc ggccaccctc tgctgggagt    240

gagcgccacc ttgaactcgg ttctcaattc caacgctatc aagaacctgc ccccaccgct    300

gggcggcgct gcggggcacc caggctctgc agtcagcgcc gcgccgggaa tcctgtaccc    360

gggcgggaat aagtaccaga ccattgacaa ctaccagccg tacccgtgcg cagaggacga    420

ggagtgcggc actgatgagt actgcgctag tcccacccgc ggaggggacg caggcgtgca    480

aatctgtctc gcctgcagga agcgccgaaa acgctgcatg cgtcacgcta tgtgctgccc    540

cgggaattac tgcaaaaatg gaatatgtgt gtcttctgat caaaatcatt tccgaggaga    600

aattgaggaa accatcactg aaagctttgg taatgatcat agcaccttgg atgggtattc    660

cagaagaacc accttgtctt caaaaatgta tcacaccaaa ggacaagaag gttctgtttg    720

tctccggtca tcagactgtg cctcaggatt gtgttgtgct agacacttct ggtccaagat    780

ctgtaaacct gtcctgaaag aaggtcaagt gtgtaccaag cataggagaa aaggctctca    840

tggactagaa atattccagc gttgttactg tggagaaggt ctgtcttgcc ggatacagaa    900

agatcaccat caagccagta attcttctag gcttcacact tgtcagagac actaaaccag    960

ctatccaaat gcagtgaact ccttttatat aatagatgct atgaaaacct tttatgacct   1020

tcatcaactc aatcctaagg atatacaagt tctgtggttt cagttaagca ttccaataac   1080

accttccaaa aacctggagt gtaagagctt tgtttcttta tggaactccc ctgtgattgc   1140

agtaaattac tgtattgtaa attctcagtg tggcacttac ctgtaaatgc aatgaaactt   1200

ttaattattt ttctaaaggt gctgcactgc ctatttttcc tcttgttatg taaatttttg   1260

tacacattga ttgttatctt gactgacaaa tattctatat tgaactgaag taaatcattt   1320

cagcttatag ttcttaaaag cataaccctt taccccattt aattctagag tctagaacgc   1380

aaggatctct tggaatgaca aatgataggt acctaaaatg taacatgaaa atactagctt   1440

attttctgaa atgtactatc ttaatgctta aattatattt ccctttaggc tgtgatagtt   1500

tttgaaataa aatttaacat ttaatatcat gaaatgttat aagtagacat acattttggg   1560

attgtgatct tagaggtttg tgtgtgtgta cgtatgtgtg tgttctacaa gaacggaagt   1620

gtgatatgtt taaagatgat cagagaaaag acagtgtcta aatataagac aatattgatc   1680

agctctagaa taactttaaa gaaagacgtg ttctgcattg ataaactcaa atgatcatgg   1740

cagaatgaga gtgaatctta cattactact ttcaaaaata gtttccaata aattaataat   1800

acctaaaaaa aaaaa                                                    1815


<210>  124
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Met Ala Leu Gly Ala Ala Gly Ala Thr Arg Val Phe Val Ala Met 
1               5                   10                  15      


Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr 
            20                  25                  30          


Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro 
        35                  40                  45              


Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro 
    50                  55                  60                  


Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr 
65                  70                  75                  80  


Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr 
                85                  90                  95      


Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val Gln Ile Cys Leu 
            100                 105                 110         


Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys 
        115                 120                 125             


Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp Gln Asn 
    130                 135                 140                 


His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn 
145                 150                 155                 160 


Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr Thr Leu Ser Ser 
                165                 170                 175     


Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
            180                 185                 190         


Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
        195                 200                 205             


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
    210                 215                 220                 


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
225                 230                 235                 240 


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
                245                 250                 255     


Ser Ser Arg Leu His Thr Cys Gln Arg His 
            260                 265     


<210>  125
<211>  1203
<212>  DNA
<213>  Homo sapiens

<400>  125
agaaagccgc gcacctcctc ccgccaggcg ctttctcgga cgccttgccc agcgggccgc     60

ccgaccccct gcaccatgga ccccgctcgc cccctggggc tgtcgattct gctgcttttc    120

ctgacggagg ctgcactggg cgatgctgct caggagccaa caggaaataa cgcggagatc    180

tgtctcctgc ccctagacta cggaccctgc cgggccctac ttctccgtta ctactacgac    240

aggtacacgc agagctgccg ccagttcctg tacgggggct gcgagggcaa cgccaacaat    300

ttctacacct gggaggcttg cgacgatgct tgctggagga tagaaaaagt tcccaaagtt    360

tgccggctgc aagtgagtgt ggacgaccag tgtgaggggt ccacagaaaa gtatttcttt    420

aatctaagtt ccatgacatg tgaaaaattc ttttccggtg ggtgtcaccg gaaccggatt    480

gagaacaggt ttccagatga agctacttgt atgggcttct gcgcaccaaa gaaaattcca    540

tcattttgct acagtccaaa agatgaggga ctgtgctctg ccaatgtgac tcgctattat    600

tttaatccaa gatacagaac ctgtgatgct ttcacctata ctggctgtgg agggaatgac    660

aataactttg ttagcaggga ggattgcaaa cgtgcatgtg caaaagcttt gaaaaagaaa    720

aagaagatgc caaagcttcg ctttgccagt agaatccgga aaattcggaa gaagcaattt    780

taaacattct taatatgtca tcttgtttgt ctttatggct tatttgcctt tatggttgta    840

tctgaagaat aatatgacag catgaggaaa caaatcattg gtgatttatt caccagtttt    900

tattaataca agtcactttt tcaaaaattt ggattttttt atatataact agctgctatt    960

caaatgtgag tctaccattt ttaatttatg gttcaactgt ttgtgagact gaattcttgc   1020

aatgcataag atataaaagc aaatatgact cactcatttc ttggggtcgt attcctgatt   1080

tcagaagagg atcataactg aaacaacata agacaatata atcatgtgct tttaacatat   1140

ttgagaataa aaaggactag caaataaaac acaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1200

aaa                                                                 1203


<210>  126
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Asp Pro Ala Arg Pro Leu Gly Leu Ser Ile Leu Leu Leu Phe Leu 
1               5                   10                  15      


Thr Glu Ala Ala Leu Gly Asp Ala Ala Gln Glu Pro Thr Gly Asn Asn 
            20                  25                  30          


Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala Leu 
        35                  40                  45              


Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln Phe 
    50                  55                  60                  


Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp Glu 
65                  70                  75                  80  


Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys Val Pro Lys Val Cys 
                85                  90                  95      


Arg Leu Gln Val Ser Val Asp Asp Gln Cys Glu Gly Ser Thr Glu Lys 
            100                 105                 110         


Tyr Phe Phe Asn Leu Ser Ser Met Thr Cys Glu Lys Phe Phe Ser Gly 
        115                 120                 125             


Gly Cys His Arg Asn Arg Ile Glu Asn Arg Phe Pro Asp Glu Ala Thr 
    130                 135                 140                 


Cys Met Gly Phe Cys Ala Pro Lys Lys Ile Pro Ser Phe Cys Tyr Ser 
145                 150                 155                 160 


Pro Lys Asp Glu Gly Leu Cys Ser Ala Asn Val Thr Arg Tyr Tyr Phe 
                165                 170                 175     


Asn Pro Arg Tyr Arg Thr Cys Asp Ala Phe Thr Tyr Thr Gly Cys Gly 
            180                 185                 190         


Gly Asn Asp Asn Asn Phe Val Ser Arg Glu Asp Cys Lys Arg Ala Cys 
        195                 200                 205             


Ala Lys Ala Leu Lys Lys Lys Lys Lys Met Pro Lys Leu Arg Phe Ala 
    210                 215                 220                 


Ser Arg Ile Arg Lys Ile Arg Lys Lys Gln Phe 
225                 230                 235 


<210>  127
<211>  2175
<212>  DNA
<213>  Homo sapiens

<400>  127
agtacagtat aaaacttcac agtgccaata ccatgaagag gagctcagac agctcttacc     60

acatgataca agagccggct ggtggaagag tggggaccag aaagagaatt tgctgaagag    120

gagaaggaaa aaaaaaacac caaaaaaaaa aataaaaaaa tccacacaca caaaaaaacc    180

tgcgcgtgag gggggaggaa aagcagggcc ttttaaaaag gcaatcacaa caacttttgc    240

tgccaggatg cccttgcttt ggctgagagg atttctgttg gcaagttgct ggattatagt    300

gaggagttcc cccaccccag gatccgaggg gcacagcgcg gcccccgact gtccgtcctg    360

tgcgctggcc gccctcccaa aggatgtacc caactctcag ccagagatgg tggaggccgt    420

caagaagcac attttaaaca tgctgcactt gaagaagaga cccgatgtca cccagccggt    480

acccaaggcg gcgcttctga acgcgatcag aaagcttcat gtgggcaaag tcggggagaa    540

cgggtatgtg gagatagagg atgacattgg aaggagggca gaaatgaatg aacttatgga    600

gcagacctcg gagatcatca cgtttgccga gtcaggaaca gccaggaaga cgctgcactt    660

cgagatttcc aaggaaggca gtgacctgtc agtggtggag cgtgcagaag tctggctctt    720

cctaaaagtc cccaaggcca acaggaccag gaccaaagtc accatccgcc tcttccagca    780

gcagaagcac ccgcagggca gcttggacac aggggaagag gccgaggaag tgggcttaaa    840

gggggagagg agtgaactgt tgctctctga aaaagtagta gacgctcgga agagcacctg    900

gcatgtcttc cctgtctcca gcagcatcca gcggttgctg gaccagggca agagctccct    960

ggacgttcgg attgcctgtg agcagtgcca ggagagtggc gccagcttgg ttctcctggg   1020

caagaagaag aagaaagaag aggaggggga agggaaaaag aagggcggag gtgaaggtgg   1080

ggcaggagca gatgaggaaa aggagcagtc gcacagacct ttcctcatgc tgcaggcccg   1140

gcagtctgaa gaccaccctc atcgccggcg tcggcggggc ttggagtgtg atggcaaggt   1200

caacatctgc tgtaagaaac agttctttgt cagtttcaag gacatcggct ggaatgactg   1260

gatcattgct ccctctggct atcatgccaa ctactgcgag ggtgagtgcc cgagccatat   1320

agcaggcacg tccgggtcct cactgtcctt ccactcaaca gtcatcaacc actaccgcat   1380

gcggggccat agcccctttg ccaacctcaa atcgtgctgt gtgcccacca agctgagacc   1440

catgtccatg ttgtactatg atgatggtca aaacatcatc aaaaaggaca ttcagaacat   1500

gatcgtggag gagtgtgggt gctcatagag ttgcccagcc cagggggaaa gggagcaaga   1560

gttgtccaga gaagacagtg gcaaaatgaa gaaattttta aggtttctga gttaaccaga   1620

aaaatagaaa ttaaaaacaa aacaaaaaaa aaaacaaaaa aaaacaaaag taaattaaaa   1680

acaaaacctg atgaaacaga tgaaggaaga tgtggaaaaa atccttagcc agggctcaga   1740

gatgaagcag tgaaagagac aggaattggg agggaaaggg agaatggtgt accctttatt   1800

tcttctgaaa tcacactgat gacatcagtt gtttaaacgg ggtattgtcc tttcccccct   1860

tgaggttccc ttgtgagcct tgaatcaacc aatctagtct gcagtagtgt ggactagaac   1920

aacccaaata gcatctagaa agccatgagt ttgaaagggc ccatcacagg cactttccta   1980

cccaattacc caggtcataa ggtatgtctg tgtgacactt atctctgtgt atatcagcat   2040

acacacacac acacacacac acacacacac acacaggcat ttccacacat tacatatata   2100

cacatactgg taaaagaaca atcgtgtgca ggtggtcaca cttccttttt ctgtaccact   2160

tttgcaacaa aacaa                                                    2175


<210>  128
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  129
<211>  3132
<212>  DNA
<213>  Homo sapiens

<400>  129
ctccaggcaa cttggggcaa gcgtctcagt tctcgctctc ccttcctccc agcggggtcg     60

ccgcagaccc cagccctggg agcaccgctc tgcagcgcgg ccggcgggtg gagacggttg    120

gcccctaaac tcgctcgtcc agcccaaccg ccccggcggc ttctcccagc cctcgaggct    180

ctcctgagcg gcctggagag gcgtcgagcg cagcccagcg cccgcctgct cacccgcccc    240

ggcccgggaa gggaattttc ggatcctgcg agcccggggc gcccccgcgg cctagggcgg    300

gcagctcccg gggcctggcc gagccggtgg cgcccgggag gccgcgggga cagcacgcag    360

cgcgcgccct tggatgccgt cccgcagcga cgccccggcc cgccccgctc ctcctcctgc    420

ctggctagcc tgcctctcat ttgggaagtt ttgtgggttt tctttctcct cctccaacct    480

tggcggaggc cacgactcag gcgccacagc tgggggctag aggccgcgga ccatggtgcg    540

gggcagccac cgctgaagtc agcaaaaccg agcctggcct gaggcaggct gcgcgggagg    600

ccaaagccat ggccattgcc acgtcgaccc agctggcccg ggcactgtat gacaacaccg    660

ctgagtcccc ccaggagctg tccttccgcc gaggggatgt cctacgggtc ctgcagagag    720

agggcgctgg tggactggac ggctggtgcc tctgctccct acacggccag cagggcattg    780

tgcccgccaa cagggtgaag ctcttgcctg ctggcccagc acccaagccc agcctctctc    840

ctgcgtcccc agcccagcct ggctcaccat atccagcccc agatcacagc aatgaggacc    900

aggaggtgta tgtggtgccg cccccagctc ggccctgtcc aacctcagga cctccagctg    960

gaccttgccc accctctcct gacctcatct acaaaatccc cagagctagt gggacccagc   1020

tggctgctcc cagagatgcc ttggaggtct acgatgtgcc ccccaccgcc ctccgggtgc   1080

cctccagtgg cccctatgac tgccctgcct ccttttccca ccctctgacc cgggttgccc   1140

cgcagccccc tggagaggat gatgctccct atgatgtgcc tctgacccca aagccacctg   1200

cagagctgga accagatctg gagtgggaag gaggccggga gccggggccc cccatctatg   1260

ctgccccctc caacctgaaa cgagcgtcag ccttactcaa tttgtatgaa gcacccgagg   1320

aactgctggc agacggggag ggcgggggca ctgatgaggg gatctacgat gtgcctctgc   1380

tggggccaga ggctccccct tctccagagc cccctggagc cttggcctcc catgaccagg   1440

acaccctggc ccagcttctg gccagaagcc ccccaccccc acacaggccc cggctcccct   1500

cagctgagag cctgtcccgc cgccctctgc ctgccctgcc tgtccctgag gcccccagcc   1560

cctccccagt gccctctcct gccccaggcc ggaagggcag catccaggac cggcctctgc   1620

ccccaccccc accccgcctg cctggttatg gaggccccaa ggtcgagggg gatccagagg   1680

gcagggagat ggaggatgac ccagcaggac accacaatga gtacgagggc attccgatgg   1740

ccgaggagta tgactatgtc cacctgaagg gcatggacaa agctcaggga tctaggcccc   1800

cggatcaggc ctgcacaggg gatcctgaac tgcccgagag ggggatgccg gcgccgcagg   1860

aggccctgtc cccaggggag ccactggttg tgtccaccgg agatctgcag ctcctgtact   1920

tctatgctgg gcaatgccag agccactact cagccctgca ggcagccgtg gcagccctga   1980

tgtccagtac ccaggctaat cagcccccgc gccttttcgt gccccacagc aagagggtgg   2040

tggtggctgc tcatcgcctg gtgtttgttg gggacaccct gggccggctg gcagcctctg   2100

cccctctgag agcacaggtc agggctgcag gtacagcact gggccaggca ttgcgggcca   2160

ctgtgctggc tgtcaaggga gctgccctgg gctacccatc cagccctgcc atccaagaga   2220

tggtgcagtg tgtaacagaa ctggcagggc aggccctgca attcactacc ctgctcacta   2280

gcctggctcc atgaaggtcc tttggcacag ctctgctcct cccctgcctg ccaaagcccc   2340

cctttaggcc ttgggtggct ggaaggcttt gttaagggac taggagaaat gggggtatct   2400

ttcccctttc ctgccctttc tgctcatctc aacctctcac agaggtgtct tctcccccta   2460

acctacagct ttttgtacaa gccattttgt gtaaattatt tatatttaat attattccct   2520

gctttgtcag gagcaggtac taggctctgg ggcagtgagg aactagatcc ttctctcctc   2580

agcctagggt ggaggtcact gcactaccac ccacctctgg aagactggct gtgaaaagtc   2640

aggtggcaga aacctggggc cacatagagc ctctctcttt tcctgtttct tggctctaga   2700

agatcagcac tgcactgtta gctgagagtg cgggcaagac ataaactgtc cagagtttga   2760

aggttctcgg aaagaccgga gggcttctcc ccacagaagg cggagagagc tggggctcag   2820

acatgggtgt gcaccttaat aaaccctgct gtctgcctcc ctgactctgc ttcttgggag   2880

catggtgagc agccctggtg ctcagcagcc atacctatgg gacacacact acgaaaagga   2940

tgcctttagg gtttggggga gattttactc ctttcttcaa caactattca ctggacaagt   3000

tctctgctcc catgacgcgc caggcacagt tctgcaagta tattgtgaat gtattgttct   3060

agtgggatac acaaataagt cagttaaaat acataaataa aaacataaac ctgccataaa   3120

aaaaaaaaaa aa                                                       3132


<210>  130
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Ala Ile Ala Thr Ser Thr Gln Leu Ala Arg Ala Leu Tyr Asp Asn 
1               5                   10                  15      


Thr Ala Glu Ser Pro Gln Glu Leu Ser Phe Arg Arg Gly Asp Val Leu 
            20                  25                  30          


Arg Val Leu Gln Arg Glu Gly Ala Gly Gly Leu Asp Gly Trp Cys Leu 
        35                  40                  45              


Cys Ser Leu His Gly Gln Gln Gly Ile Val Pro Ala Asn Arg Val Lys 
    50                  55                  60                  


Leu Leu Pro Ala Gly Pro Ala Pro Lys Pro Ser Leu Ser Pro Ala Ser 
65                  70                  75                  80  


Pro Ala Gln Pro Gly Ser Pro Tyr Pro Ala Pro Asp His Ser Asn Glu 
                85                  90                  95      


Asp Gln Glu Val Tyr Val Val Pro Pro Pro Ala Arg Pro Cys Pro Thr 
            100                 105                 110         


Ser Gly Pro Pro Ala Gly Pro Cys Pro Pro Ser Pro Asp Leu Ile Tyr 
        115                 120                 125             


Lys Ile Pro Arg Ala Ser Gly Thr Gln Leu Ala Ala Pro Arg Asp Ala 
    130                 135                 140                 


Leu Glu Val Tyr Asp Val Pro Pro Thr Ala Leu Arg Val Pro Ser Ser 
145                 150                 155                 160 


Gly Pro Tyr Asp Cys Pro Ala Ser Phe Ser His Pro Leu Thr Arg Val 
                165                 170                 175     


Ala Pro Gln Pro Pro Gly Glu Asp Asp Ala Pro Tyr Asp Val Pro Leu 
            180                 185                 190         


Thr Pro Lys Pro Pro Ala Glu Leu Glu Pro Asp Leu Glu Trp Glu Gly 
        195                 200                 205             


Gly Arg Glu Pro Gly Pro Pro Ile Tyr Ala Ala Pro Ser Asn Leu Lys 
    210                 215                 220                 


Arg Ala Ser Ala Leu Leu Asn Leu Tyr Glu Ala Pro Glu Glu Leu Leu 
225                 230                 235                 240 


Ala Asp Gly Glu Gly Gly Gly Thr Asp Glu Gly Ile Tyr Asp Val Pro 
                245                 250                 255     


Leu Leu Gly Pro Glu Ala Pro Pro Ser Pro Glu Pro Pro Gly Ala Leu 
            260                 265                 270         


Ala Ser His Asp Gln Asp Thr Leu Ala Gln Leu Leu Ala Arg Ser Pro 
        275                 280                 285             


Pro Pro Pro His Arg Pro Arg Leu Pro Ser Ala Glu Ser Leu Ser Arg 
    290                 295                 300                 


Arg Pro Leu Pro Ala Leu Pro Val Pro Glu Ala Pro Ser Pro Ser Pro 
305                 310                 315                 320 


Val Pro Ser Pro Ala Pro Gly Arg Lys Gly Ser Ile Gln Asp Arg Pro 
                325                 330                 335     


Leu Pro Pro Pro Pro Pro Arg Leu Pro Gly Tyr Gly Gly Pro Lys Val 
            340                 345                 350         


Glu Gly Asp Pro Glu Gly Arg Glu Met Glu Asp Asp Pro Ala Gly His 
        355                 360                 365             


His Asn Glu Tyr Glu Gly Ile Pro Met Ala Glu Glu Tyr Asp Tyr Val 
    370                 375                 380                 


His Leu Lys Gly Met Asp Lys Ala Gln Gly Ser Arg Pro Pro Asp Gln 
385                 390                 395                 400 


Ala Cys Thr Gly Asp Pro Glu Leu Pro Glu Arg Gly Met Pro Ala Pro 
                405                 410                 415     


Gln Glu Ala Leu Ser Pro Gly Glu Pro Leu Val Val Ser Thr Gly Asp 
            420                 425                 430         


Leu Gln Leu Leu Tyr Phe Tyr Ala Gly Gln Cys Gln Ser His Tyr Ser 
        435                 440                 445             


Ala Leu Gln Ala Ala Val Ala Ala Leu Met Ser Ser Thr Gln Ala Asn 
    450                 455                 460                 


Gln Pro Pro Arg Leu Phe Val Pro His Ser Lys Arg Val Val Val Ala 
465                 470                 475                 480 


Ala His Arg Leu Val Phe Val Gly Asp Thr Leu Gly Arg Leu Ala Ala 
                485                 490                 495     


Ser Ala Pro Leu Arg Ala Gln Val Arg Ala Ala Gly Thr Ala Leu Gly 
            500                 505                 510         


Gln Ala Leu Arg Ala Thr Val Leu Ala Val Lys Gly Ala Ala Leu Gly 
        515                 520                 525             


Tyr Pro Ser Ser Pro Ala Ile Gln Glu Met Val Gln Cys Val Thr Glu 
    530                 535                 540                 


Leu Ala Gly Gln Ala Leu Gln Phe Thr Thr Leu Leu Thr Ser Leu Ala 
545                 550                 555                 560 


Pro 
    


<210>  131
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  131
ctcacttggc cttacactcc gctcggctca ccatgtgtca ctctcgcagc tgccacccga     60

ccatgaccat cctgcaggcc ccgaccccgg ccccctccac catcccggga ccccggcggg    120

gctccggtcc tgagatcttc accttcgacc ctctcccgga gcccgcagcg gcccctgccg    180

ggcgccccag cgcctctcgc gggcaccgaa agcgcagccg cagggttctc taccctcgag    240

tggtccggcg ccagctgcca gtcgaggaac cgaacccagc caaaaggctt ctctttctgc    300

tgctcaccat cgtcttctgc cagatcctga tggctgaaga gggtgtgccg gcgcccctgc    360

ctccagagga cgcccctaac gccgcatccc tggcgcccac ccctgtgtcc gccgtcctcg    420

agccctttaa tctgacttcg gagccctcgg actacgctct ggacctcagc actttcctcc    480

agcaacaccc ggccgccttc taactgtgac tccccgcact ccccaaaaag aatccgaaaa    540

accacaaaga aacaccaggc gtacctggtg cgcgagagcg tatccccaac tgggacttcc    600

gaggcaactt gaactcagaa cactacagcg gagacgccac ccggtgcttg aggcgggacc    660

gaggcgcaca gagaccgagg cgcatagaga ccgaggcaca gcccagctgg ggctaggccc    720

ggtgggaagg agagcgtcgt taatttattt cttattgctc ctaattaata tttatatgta    780

tttatgtacg tcctcctagg tgatggagat gtgtacgtaa tatttatttt aacttatgca    840

agggtgtgag atgttccccc tgctgtaaat gcaggtctct tggtatttat tgagctttgt    900

gggactggtg gaagcaggac acctggaact gcggcaaagt aggagaagaa atggggagga    960

ctcgggtggg ggaggacgtc ccggctggga tgaagtctgg tggtgggtcg taagtttagg   1020

aggtgactgc atcctccagc atctcaactc cgtctgtcta ctgtgtgaga cttcggcgga   1080

ccattaggaa tgagatccgt gagatccttc catcttcttg aagtcgcctt tagggtggct   1140

gcgaggtaga gggttggggg ttggtgggct gtcacggagc gactgtcgag atcgcctagt   1200

atgttctgtg aacacaaata aaattgattt actgtctgca aaaaaaaaaa aaaa         1254


<210>  132
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Cys His Ser Arg Ser Cys His Pro Thr Met Thr Ile Leu Gln Ala 
1               5                   10                  15      


Pro Thr Pro Ala Pro Ser Thr Ile Pro Gly Pro Arg Arg Gly Ser Gly 
            20                  25                  30          


Pro Glu Ile Phe Thr Phe Asp Pro Leu Pro Glu Pro Ala Ala Ala Pro 
        35                  40                  45              


Ala Gly Arg Pro Ser Ala Ser Arg Gly His Arg Lys Arg Ser Arg Arg 
    50                  55                  60                  


Val Leu Tyr Pro Arg Val Val Arg Arg Gln Leu Pro Val Glu Glu Pro 
65                  70                  75                  80  


Asn Pro Ala Lys Arg Leu Leu Phe Leu Leu Leu Thr Ile Val Phe Cys 
                85                  90                  95      


Gln Ile Leu Met Ala Glu Glu Gly Val Pro Ala Pro Leu Pro Pro Glu 
            100                 105                 110         


Asp Ala Pro Asn Ala Ala Ser Leu Ala Pro Thr Pro Val Ser Pro Val 
        115                 120                 125             


Leu Glu Pro Phe Asn Leu Thr Ser Glu Pro Ser Asp Tyr Ala Leu Asp 
    130                 135                 140                 


Leu Ser Thr Phe Leu Gln Gln His Pro Ala Ala Phe 
145                 150                 155     


<210>  133
<211>  6641
<212>  DNA
<213>  Homo sapiens

<400>  133
gccctcgccg cccgcggcgc cccgagcgct ttgtgagcag atgcggagcc gagtggaggg     60

cgcgagccag atgcggggcg acagctgact tgctgagagg aggcggggag gcgcggagcg    120

cgcgtgtggt ccttgcgccg ctgacttctc cactggttcc tgggcaccga aagataaacc    180

tctcataatg aaggcccccg ctgtgcttgc acctggcatc ctcgtgctcc tgtttacctt    240

ggtgcagagg agcaatgggg agtgtaaaga ggcactagca aagtccgaga tgaatgtgaa    300

tatgaagtat cagcttccca acttcaccgc ggaaacaccc atccagaatg tcattctaca    360

tgagcatcac attttccttg gtgccactaa ctacatttat gttttaaatg aggaagacct    420

tcagaaggtt gctgagtaca agactgggcc tgtgctggaa cacccagatt gtttcccatg    480

tcaggactgc agcagcaaag ccaatttatc aggaggtgtt tggaaagata acatcaacat    540

ggctctagtt gtcgacacct actatgatga tcaactcatt agctgtggca gcgtcaacag    600

agggacctgc cagcgacatg tctttcccca caatcatact gctgacatac agtcggaggt    660

tcactgcata ttctccccac agatagaaga gcccagccag tgtcctgact gtgtggtgag    720

cgccctggga gccaaagtcc tttcatctgt aaaggaccgg ttcatcaact tctttgtagg    780

caataccata aattcttctt atttcccaga tcatccattg cattcgatat cagtgagaag    840

gctaaaggaa acgaaagatg gttttatgtt tttgacggac cagtcctaca ttgatgtttt    900

acctgagttc agagattctt accccattaa gtatgtccat gcctttgaaa gcaacaattt    960

tatttacttc ttgacggtcc aaagggaaac tctagatgct cagacttttc acacaagaat   1020

aatcaggttc tgttccataa actctggatt gcattcctac atggaaatgc ctctggagtg   1080

tattctcaca gaaaagagaa aaaagagatc cacaaagaag gaagtgttta atatacttca   1140

ggctgcgtat gtcagcaagc ctggggccca gcttgctaga caaataggag ccagcctgaa   1200

tgatgacatt cttttcgggg tgttcgcaca aagcaagcca gattctgccg aaccaatgga   1260

tcgatctgcc atgtgtgcat tccctatcaa atatgtcaac gacttcttca acaagatcgt   1320

caacaaaaac aatgtgagat gtctccagca tttttacgga cccaatcatg agcactgctt   1380

taataggaca cttctgagaa attcatcagg ctgtgaagcg cgccgtgatg aatatcgaac   1440

agagtttacc acagctttgc agcgcgttga cttattcatg ggtcaattca gcgaagtcct   1500

cttaacatct atatccacct tcattaaagg agacctcacc atagctaatc ttgggacatc   1560

agagggtcgc ttcatgcagg ttgtggtttc tcgatcagga ccatcaaccc ctcatgtgaa   1620

ttttctcctg gactcccatc cagtgtctcc agaagtgatt gtggagcata cattaaacca   1680

aaatggctac acactggtta tcactgggaa gaagatcacg aagatcccat tgaatggctt   1740

gggctgcaga catttccagt cctgcagtca atgcctctct gccccaccct ttgttcagtg   1800

tggctggtgc cacgacaaat gtgtgcgatc ggaggaatgc ctgagcggga catggactca   1860

acagatctgt ctgcctgcaa tctacaaggt tttcccaaat agtgcacccc ttgaaggagg   1920

gacaaggctg accatatgtg gctgggactt tggatttcgg aggaataata aatttgattt   1980

aaagaaaact agagttctcc ttggaaatga gagctgcacc ttgactttaa gtgagagcac   2040

gatgaataca ttgaaatgca cagttggtcc tgccatgaat aagcatttca atatgtccat   2100

aattatttca aatggccacg ggacaacaca atacagtaca ttctcctatg tggatcctgt   2160

aataacaagt atttcgccga aatacggtcc tatggctggt ggcactttac ttactttaac   2220

tggaaattac ctaaacagtg ggaattctag acacatttca attggtggaa aaacatgtac   2280

tttaaaaagt gtgtcaaaca gtattcttga atgttatacc ccagcccaaa ccatttcaac   2340

tgagtttgct gttaaattga aaattgactt agccaaccga gagacaagca tcttcagtta   2400

ccgtgaagat cccattgtct atgaaattca tccaaccaaa tcttttatta gtggtgggag   2460

cacaataaca ggtgttggga aaaacctgaa ttcagttagt gtcccgagaa tggtcataaa   2520

tgtgcatgaa gcaggaagga actttacagt ggcatgtcaa catcgctcta attcagagat   2580

aatctgttgt accactcctt ccctgcaaca gctgaatctg caactccccc tgaaaaccaa   2640

agcctttttc atgttagatg ggatcctttc caaatacttt gatctcattt atgtacataa   2700

tcctgtgttt aagccttttg aaaagccagt gatgatctca atgggcaatg aaaatgtact   2760

ggaaattaag ggaaatgata ttgaccctga agcagttaaa ggtgaagtgt taaaagttgg   2820

aaataagagc tgtgagaata tacacttaca ttctgaagcc gttttatgca cggtccccaa   2880

tgacctgctg aaattgaaca gcgagctaaa tatagagtgg aagcaagcaa tttcttcaac   2940

cgtccttgga aaagtaatag ttcaaccaga tcagaatttc acaggattga ttgctggtgt   3000

tgtctcaata tcaacagcac tgttattact acttgggttt ttcctgtggc tgaaaaagag   3060

aaagcaaatt aaagatctgg gcagtgaatt agttcgctac gatgcaagag tacacactcc   3120

tcatttggat aggcttgtaa gtgcccgaag tgtaagccca actacagaaa tggtttcaaa   3180

tgaatctgta gactaccgag ctacttttcc agaagatcag tttcctaatt catctcagaa   3240

cggttcatgc cgacaagtgc agtatcctct gacagacatg tcccccatcc taactagtgg   3300

ggactctgat atatccagtc cattactgca aaatactgtc cacattgacc tcagtgctct   3360

aaatccagag ctggtccagg cagtgcagca tgtagtgatt gggcccagta gcctgattgt   3420

gcatttcaat gaagtcatag gaagagggca ttttggttgt gtatatcatg ggactttgtt   3480

ggacaatgat ggcaagaaaa ttcactgtgc tgtgaaatcc ttgaacagaa tcactgacat   3540

aggagaagtt tcccaatttc tgaccgaggg aatcatcatg aaagatttta gtcatcccaa   3600

tgtcctctcg ctcctgggaa tctgcctgcg aagtgaaggg tctccgctgg tggtcctacc   3660

atacatgaaa catggagatc ttcgaaattt cattcgaaat gagactcata atccaactgt   3720

aaaagatctt attggctttg gtcttcaagt agccaaaggc atgaaatatc ttgcaagcaa   3780

aaagtttgtc cacagagact tggctgcaag aaactgtatg ctggatgaaa aattcacagt   3840

caaggttgct gattttggtc ttgccagaga catgtatgat aaagaatact atagtgtaca   3900

caacaaaaca ggtgcaaagc tgccagtgaa gtggatggct ttggaaagtc tgcaaactca   3960

aaagtttacc accaagtcag atgtgtggtc ctttggcgtg ctcctctggg agctgatgac   4020

aagaggagcc ccaccttatc ctgacgtaaa cacctttgat ataactgttt acttgttgca   4080

agggagaaga ctcctacaac ccgaatactg cccagacccc ttatatgaag taatgctaaa   4140

atgctggcac cctaaagccg aaatgcgccc atccttttct gaactggtgt cccggatatc   4200

agcgatcttc tctactttca ttggggagca ctatgtccat gtgaacgcta cttatgtgaa   4260

cgtaaaatgt gtcgctccgt atccttctct gttgtcatca gaagataacg ctgatgatga   4320

ggtggacaca cgaccagcct ccttctggga gacatcatag tgctagtact atgtcaaagc   4380

aacagtccac actttgtcca atggtttttt cactgcctga cctttaaaag gccatcgata   4440

ttctttgctc ttgccaaaat tgcactatta taggacttgt attgttattt aaattactgg   4500

attctaagga atttcttatc tgacagagca tcagaaccag aggcttggtc ccacaggcca   4560

cggaccaatg gcctgcagcc gtgacaacac tcctgtcata ttggagtcca aaacttgaat   4620

tctgggttga attttttaaa aatcaggtac cacttgattt catatgggaa attgaagcag   4680

gaaatattga gggcttcttg atcacagaaa actcagaaga gatagtaatg ctcaggacag   4740

gagcggcagc cccagaacag gccactcatt tagaattcta gtgtttcaaa acacttttgt   4800

gtgttgtatg gtcaataaca tttttcatta ctgatggtgt cattcaccca ttaggtaaac   4860

attccctttt aaatgtttgt ttgttttttg agacaggatc tcactctgtt gccagggctg   4920

tagtgcagtg gtgtgatcat agctcactgc aacctccacc tcccaggctc aagcctcccg   4980

aatagctggg actacaggcg cacaccacca tccccggcta atttttgtat tttttgtaga   5040

gacggggttt tgccatgttg ccaaggctgg tttcaaactc ctggactcaa gaaatccacc   5100

cacctcagcc tcccaaagtg ctaggattac aggcatgagc cactgcgccc agcccttata   5160

aatttttgta tagacattcc tttggttgga agaatattta taggcaatac agtcaaagtt   5220

tcaaaatagc atcacacaaa acatgtttat aaatgaacag gatgtaatgt acatagatga   5280

cattaagaaa atttgtatga aataatttag tcatcatgaa atatttagtt gtcatataaa   5340

aacccactgt ttgagaatga tgctactctg atctaatgaa tgtgaacatg tagatgtttt   5400

gtgtgtattt ttttaaatga aaactcaaaa taagacaagt aatttgttga taaatatttt   5460

taaagataac tcagcatgtt tgtaaagcag gatacatttt actaaaaggt tcattggttc   5520

caatcacagc tcataggtag agcaaagaaa gggtggatgg attgaaaaga ttagcctctg   5580

tctcggtggc aggttcccac ctcgcaagca attggaaaca aaacttttgg ggagttttat   5640

tttgcattag ggtgtgtttt atgttaagca aaacatactt tagaaacaaa tgaaaaaggc   5700

aattgaaaat cccagctatt tcacctagat ggaatagcca ccctgagcag aactttgtga   5760

tgcttcattc tgtggaattt tgtgcttgct actgtatagt gcatgtggtg taggttactc   5820

taactggttt tgtcgacgta aacatttaaa gtgttatatt ttttataaaa atgtttattt   5880

ttaatgatat gagaaaaatt ttgttaggcc acaaaaacac tgcactgtga acattttaga   5940

aaaggtatgt cagactggga ttaatgacag catgattttc aatgactgta aattgcgata   6000

aggaaatgta ctgattgcca atacacccca ccctcattac atcatcagga cttgaagcca   6060

agggttaacc cagcaagcta caaagagggt gtgtcacact gaaactcaat agttgagttt   6120

ggctgttgtt gcaggaaaat gattataact aaaagctctc tgatagtgca gagacttacc   6180

agaagacaca aggaattgta ctgaagagct attacaatcc aaatattgcc gtttcataaa   6240

tgtaataagt aatactaatt cacagagtat tgtaaatggt ggatgacaaa agaaaatctg   6300

ctctgtggaa agaaagaact gtctctacca gggtcaagag catgaacgca tcaatagaaa   6360

gaactcgggg aaacatccca tcaacaggac tacacacttg tatatacatt cttgagaaca   6420

ctgcaatgtg aaaatcacgt ttgctattta taaacttgtc cttagattaa tgtgtctgga   6480

cagattgtgg gagtaagtga ttcttctaag aattagatac ttgtcactgc ctatacctgc   6540

agctgaactg aatggtactt cgtatgttaa tagttgttct gataaatcat gcaattaaag   6600

taaagtgatg caacatcttg taaaaaaaaa aaaaaaaaaa a                       6641


<210>  134
<211>  1390
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210>  135
<211>  4093
<212>  DNA
<213>  Homo sapiens

<400>  135
cagaggtgag gctgttgttt aaaaacctgg agccgggagg ggagaccccc acattcaaga     60

ggagctttca ggcgatctgg agaaagaacg gcagaacaca cagcaaggaa aggtcctttc    120

tggggatcac cccattggct gaagatgaga ccattcttcc tcttgtgttt tgccctgcct    180

ggcctcctgc atgcccaaca agcctgctcc cgtggggcct gctatccacc tgttggggac    240

ctgcttgttg ggaggacccg gtttctccga gcttcatcta cctgtggact gaccaagcct    300

gagacctact gcacccagta tggcgagtgg cagatgaaat gctgcaagtg tgactccagg    360

cagcctcaca actactacag tcaccgagta gagaatgtgg cttcatcctc cggccccatg    420

cgctggtggc agtcacagaa tgatgtgaac cctgtctctc tgcagctgga cctggacagg    480

agattccagc ttcaagaagt catgatggag ttccaggggc ccatgcccgc cggcatgctg    540

attgagcgct cctcagactt cggtaagacc tggcgagtgt accagtacct ggctgccgac    600

tgcacctcca ccttccctcg ggtccgccag ggtcggcctc agagctggca ggatgttcgg    660

tgccagtccc tgcctcagag gcctaatgca cgcctaaatg gggggaaggt ccaacttaac    720

cttatggatt tagtgtctgg gattccagca actcaaagtc aaaaaattca agaggtgggg    780

gagatcacaa acttgagagt caatttcacc aggctggccc ctgtgcccca aaggggctac    840

caccctccca gcgcctacta tgctgtgtcc cagctccgtc tgcaggggag ctgcttctgt    900

cacggccatg ctgatcgctg cgcacccaag cctggggcct ctgcaggccc ctccaccgct    960

gtgcaggtcc acgatgtctg tgtctgccag cacaacactg ccggcccaaa ttgtgagcgc   1020

tgtgcaccct tctacaacaa ccggccctgg agaccggcgg agggccagga cgcccatgaa   1080

tgccaaaggt gcgactgcaa tgggcactca gagacatgtc actttgaccc cgctgtgttt   1140

gccgccagcc agggggcata tggaggtgtg tgtgacaatt gccgggacca caccgaaggc   1200

aagaactgtg agcggtgtca gctgcactat ttccggaacc ggcgcccggg agcttccatt   1260

caggagacct gcatctcctg cgagtgtgat ccggatgggg cagtgccagg ggctccctgt   1320

gacccagtga ccgggcagtg tgtgtgcaag gagcatgtgc agggagagcg ctgtgaccta   1380

tgcaagccgg gcttcactgg actcacctac gccaacccgc agggctgcca ccgctgtgac   1440

tgcaacatcc tggggtcccg gagggacatg ccgtgtgacg aggagagtgg gcgctgcctt   1500

tgtctgccca acgtggtggg tcccaaatgt gaccagtgtg ctccctacca ctggaagctg   1560

gccagtggcc agggctgtga accgtgtgcc tgcgacccgc acaactccct cagcccacag   1620

tgcaaccagt tcacagggca gtgcccctgt cgggaaggct ttggtggcct gatgtgcagc   1680

gctgcagcca tccgccagtg tccagaccgg acctatggag acgtggccac aggatgccga   1740

gcctgtgact gtgatttccg gggaacagag ggcccgggct gcgacaaggc atcaggccgc   1800

tgcctctgcc gccctggctt gaccgggccc cgctgtgacc agtgccagcg aggctactgt   1860

aatcgctacc cggtgtgcgt ggcctgccac ccttgcttcc agacctatga tgcggacctc   1920

cgggagcagg ccctgcgctt tggtagactc cgcaatgcca ccgccagcct gtggtcaggg   1980

cctgggctgg aggaccgtgg cctggcctcc cggatcctag atgcaaagag taagattgag   2040

cagatccgag cagttctcag cagccccgca gtcacagagc aggaggtggc tcaggtggcc   2100

agtgccatcc tctccctcag gcgaactctc cagggcctgc agctggatct gcccctggag   2160

gaggagacgt tgtcccttcc gagagacctg gagagtcttg acagaagctt caatggtctc   2220

cttactatgt atcagaggaa gagggagcag tttgaaaaaa taagcagtgc tgatccttca   2280

ggagccttcc ggatgctgag cacagcctac gagcagtcag cccaggctgc tcagcaggtc   2340

tccgacagct cgcgcctttt ggaccagctc agggacagcc ggagagaggc agagaggctg   2400

gtgcggcagg cgggaggagg aggaggcacc ggcagcccca agcttgtggc cctgaggctg   2460

gagatgtctt cgttgcctga cctgacaccc accttcaaca agctctgtgg caactccagg   2520

cagatggctt gcaccccaat atcatgccct ggtgagctat gtccccaaga caatggcaca   2580

gcctgtggct cccgctgcag gggtgtcctt cccagggccg gtggggcctt cttgatggcg   2640

gggcaggtgg ctgagcagct gcggggcttc aatgcccagc tccagcggac caggcagatg   2700

attagggcag ccgaggaatc tgcctcacag attcaatcca gtgcccagcg cttggagacc   2760

caggtgagcg ccagccgctc ccagatggag gaagatgtca gacgcacacg gctcctaatc   2820

cagcaggtcc gggacttcct aacagacccc gacactgatg cagccactat ccaggaggtc   2880

agcgaggccg tgctggccct gtggctgccc acagactcag ctactgttct gcagaagatg   2940

aatgagatcc aggccattgc agccaggctc cccaacgtgg acttggtgct gtcccagacc   3000

aagcaggaca ttgcgcgtgc ccgccggttg caggctgagg ctgaggaagc caggagccga   3060

gcccatgcag tggagggcca ggtggaagat gtggttggga acctgcggca ggggacagtg   3120

gcactgcagg aagctcagga caccatgcaa ggcaccagcc gctcccttcg gcttatccag   3180

gacagggttg ctgaggttca gcaggtactg cggccagcag aaaagctggt gacaagcatg   3240

accaagcagc tgggtgactt ctggacacgg atggaggagc tccgccacca agcccggcag   3300

cagggggcag aggcagtcca ggcccagcag cttgcggaag gtgccagcga gcaggcattg   3360

agtgcccaag agggatttga gagaataaaa caaaagtatg ctgagttgaa ggaccggttg   3420

ggtcagagtt ccatgctggg tgagcagggt gcccggatcc agagtgtgaa gacagaggca   3480

gaggagctgt ttggggagac catggagatg atggacagga tgaaagacat ggagttggag   3540

ctgctgcggg gcagccaggc catcatgctg cgctcagcgg acctgacagg actggagaag   3600

cgtgtggagc agatccgtga ccacatcaat gggcgcgtgc tctactatgc cacctgcaag   3660

tgatgctaca gcttccagcc cgttgcccca ctcatctgcc gcctttgctt ttggttgggg   3720

gcagattggg ttggaatgct ttccatctcc aggagacttt catgcagcct aaagtacagc   3780

ctggaccacc cctggtgtgt agctagtaag attaccctga gctgcagctg agcctgagcc   3840

aatgggacag ttacacttga cagacaaaga tggtggagat tggcatgcca ttgaaactaa   3900

gagctctcaa gtcaaggaag ctgggctggg cagtatcccc cgcctttagt tctccactgg   3960

ggaggaatcc tggaccaagc acaaaaactt aacaaaagtg atgtaaaaat gaaaagccaa   4020

ataaaaatct ttggaaaaga gcctggaggt tcaacgagga aaaaaaaaaa aaaaaaaaaa   4080

aaaaaaaaaa aaa                                                      4093


<210>  136
<211>  1172
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Arg Pro Phe Phe Leu Leu Cys Phe Ala Leu Pro Gly Leu Leu His 
1               5                   10                  15      


Ala Gln Gln Ala Cys Ser Arg Gly Ala Cys Tyr Pro Pro Val Gly Asp 
            20                  25                  30          


Leu Leu Val Gly Arg Thr Arg Phe Leu Arg Ala Ser Ser Thr Cys Gly 
        35                  40                  45              


Leu Thr Lys Pro Glu Thr Tyr Cys Thr Gln Tyr Gly Glu Trp Gln Met 
    50                  55                  60                  


Lys Cys Cys Lys Cys Asp Ser Arg Gln Pro His Asn Tyr Tyr Ser His 
65                  70                  75                  80  


Arg Val Glu Asn Val Ala Ser Ser Ser Gly Pro Met Arg Trp Trp Gln 
                85                  90                  95      


Ser Gln Asn Asp Val Asn Pro Val Ser Leu Gln Leu Asp Leu Asp Arg 
            100                 105                 110         


Arg Phe Gln Leu Gln Glu Val Met Met Glu Phe Gln Gly Pro Met Pro 
        115                 120                 125             


Ala Gly Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp Arg 
    130                 135                 140                 


Val Tyr Gln Tyr Leu Ala Ala Asp Cys Thr Ser Thr Phe Pro Arg Val 
145                 150                 155                 160 


Arg Gln Gly Arg Pro Gln Ser Trp Gln Asp Val Arg Cys Gln Ser Leu 
                165                 170                 175     


Pro Gln Arg Pro Asn Ala Arg Leu Asn Gly Gly Lys Val Gln Leu Asn 
            180                 185                 190         


Leu Met Asp Leu Val Ser Gly Ile Pro Ala Thr Gln Ser Gln Lys Ile 
        195                 200                 205             


Gln Glu Val Gly Glu Ile Thr Asn Leu Arg Val Asn Phe Thr Arg Leu 
    210                 215                 220                 


Ala Pro Val Pro Gln Arg Gly Tyr His Pro Pro Ser Ala Tyr Tyr Ala 
225                 230                 235                 240 


Val Ser Gln Leu Arg Leu Gln Gly Ser Cys Phe Cys His Gly His Ala 
                245                 250                 255     


Asp Arg Cys Ala Pro Lys Pro Gly Ala Ser Ala Gly Pro Ser Thr Ala 
            260                 265                 270         


Val Gln Val His Asp Val Cys Val Cys Gln His Asn Thr Ala Gly Pro 
        275                 280                 285             


Asn Cys Glu Arg Cys Ala Pro Phe Tyr Asn Asn Arg Pro Trp Arg Pro 
    290                 295                 300                 


Ala Glu Gly Gln Asp Ala His Glu Cys Gln Arg Cys Asp Cys Asn Gly 
305                 310                 315                 320 


His Ser Glu Thr Cys His Phe Asp Pro Ala Val Phe Ala Ala Ser Gln 
                325                 330                 335     


Gly Ala Tyr Gly Gly Val Cys Asp Asn Cys Arg Asp His Thr Glu Gly 
            340                 345                 350         


Lys Asn Cys Glu Arg Cys Gln Leu His Tyr Phe Arg Asn Arg Arg Pro 
        355                 360                 365             


Gly Ala Ser Ile Gln Glu Thr Cys Ile Ser Cys Glu Cys Asp Pro Asp 
    370                 375                 380                 


Gly Ala Val Pro Gly Ala Pro Cys Asp Pro Val Thr Gly Gln Cys Val 
385                 390                 395                 400 


Cys Lys Glu His Val Gln Gly Glu Arg Cys Asp Leu Cys Lys Pro Gly 
                405                 410                 415     


Phe Thr Gly Leu Thr Tyr Ala Asn Pro Gln Gly Cys His Arg Cys Asp 
            420                 425                 430         


Cys Asn Ile Leu Gly Ser Arg Arg Asp Met Pro Cys Asp Glu Glu Ser 
        435                 440                 445             


Gly Arg Cys Leu Cys Leu Pro Asn Val Val Gly Pro Lys Cys Asp Gln 
    450                 455                 460                 


Cys Ala Pro Tyr His Trp Lys Leu Ala Ser Gly Gln Gly Cys Glu Pro 
465                 470                 475                 480 


Cys Ala Cys Asp Pro His Asn Ser Leu Ser Pro Gln Cys Asn Gln Phe 
                485                 490                 495     


Thr Gly Gln Cys Pro Cys Arg Glu Gly Phe Gly Gly Leu Met Cys Ser 
            500                 505                 510         


Ala Ala Ala Ile Arg Gln Cys Pro Asp Arg Thr Tyr Gly Asp Val Ala 
        515                 520                 525             


Thr Gly Cys Arg Ala Cys Asp Cys Asp Phe Arg Gly Thr Glu Gly Pro 
    530                 535                 540                 


Gly Cys Asp Lys Ala Ser Gly Arg Cys Leu Cys Arg Pro Gly Leu Thr 
545                 550                 555                 560 


Gly Pro Arg Cys Asp Gln Cys Gln Arg Gly Tyr Cys Asn Arg Tyr Pro 
                565                 570                 575     


Val Cys Val Ala Cys His Pro Cys Phe Gln Thr Tyr Asp Ala Asp Leu 
            580                 585                 590         


Arg Glu Gln Ala Leu Arg Phe Gly Arg Leu Arg Asn Ala Thr Ala Ser 
        595                 600                 605             


Leu Trp Ser Gly Pro Gly Leu Glu Asp Arg Gly Leu Ala Ser Arg Ile 
    610                 615                 620                 


Leu Asp Ala Lys Ser Lys Ile Glu Gln Ile Arg Ala Val Leu Ser Ser 
625                 630                 635                 640 


Pro Ala Val Thr Glu Gln Glu Val Ala Gln Val Ala Ser Ala Ile Leu 
                645                 650                 655     


Ser Leu Arg Arg Thr Leu Gln Gly Leu Gln Leu Asp Leu Pro Leu Glu 
            660                 665                 670         


Glu Glu Thr Leu Ser Leu Pro Arg Asp Leu Glu Ser Leu Asp Arg Ser 
        675                 680                 685             


Phe Asn Gly Leu Leu Thr Met Tyr Gln Arg Lys Arg Glu Gln Phe Glu 
    690                 695                 700                 


Lys Ile Ser Ser Ala Asp Pro Ser Gly Ala Phe Arg Met Leu Ser Thr 
705                 710                 715                 720 


Ala Tyr Glu Gln Ser Ala Gln Ala Ala Gln Gln Val Ser Asp Ser Ser 
                725                 730                 735     


Arg Leu Leu Asp Gln Leu Arg Asp Ser Arg Arg Glu Ala Glu Arg Leu 
            740                 745                 750         


Val Arg Gln Ala Gly Gly Gly Gly Gly Thr Gly Ser Pro Lys Leu Val 
        755                 760                 765             


Ala Leu Arg Leu Glu Met Ser Ser Leu Pro Asp Leu Thr Pro Thr Phe 
    770                 775                 780                 


Asn Lys Leu Cys Gly Asn Ser Arg Gln Met Ala Cys Thr Pro Ile Ser 
785                 790                 795                 800 


Cys Pro Gly Glu Leu Cys Pro Gln Asp Asn Gly Thr Ala Cys Gly Ser 
                805                 810                 815     


Arg Cys Arg Gly Val Leu Pro Arg Ala Gly Gly Ala Phe Leu Met Ala 
            820                 825                 830         


Gly Gln Val Ala Glu Gln Leu Arg Gly Phe Asn Ala Gln Leu Gln Arg 
        835                 840                 845             


Thr Arg Gln Met Ile Arg Ala Ala Glu Glu Ser Ala Ser Gln Ile Gln 
    850                 855                 860                 


Ser Ser Ala Gln Arg Leu Glu Thr Gln Val Ser Ala Ser Arg Ser Gln 
865                 870                 875                 880 


Met Glu Glu Asp Val Arg Arg Thr Arg Leu Leu Ile Gln Gln Val Arg 
                885                 890                 895     


Asp Phe Leu Thr Asp Pro Asp Thr Asp Ala Ala Thr Ile Gln Glu Val 
            900                 905                 910         


Ser Glu Ala Val Leu Ala Leu Trp Leu Pro Thr Asp Ser Ala Thr Val 
        915                 920                 925             


Leu Gln Lys Met Asn Glu Ile Gln Ala Ile Ala Ala Arg Leu Pro Asn 
    930                 935                 940                 


Val Asp Leu Val Leu Ser Gln Thr Lys Gln Asp Ile Ala Arg Ala Arg 
945                 950                 955                 960 


Arg Leu Gln Ala Glu Ala Glu Glu Ala Arg Ser Arg Ala His Ala Val 
                965                 970                 975     


Glu Gly Gln Val Glu Asp Val Val Gly Asn Leu Arg Gln Gly Thr Val 
            980                 985                 990         


Ala Leu Gln Glu Ala Gln Asp Thr  Met Gln Gly Thr Ser  Arg Ser Leu 
        995                 1000                 1005             


Arg Leu  Ile Gln Asp Arg Val  Ala Glu Val Gln Gln  Val Leu Arg 
    1010                 1015                 1020             


Pro Ala  Glu Lys Leu Val Thr  Ser Met Thr Lys Gln  Leu Gly Asp 
    1025                 1030                 1035             


Phe Trp  Thr Arg Met Glu Glu  Leu Arg His Gln Ala  Arg Gln Gln 
    1040                 1045                 1050             


Gly Ala  Glu Ala Val Gln Ala  Gln Gln Leu Ala Glu  Gly Ala Ser 
    1055                 1060                 1065             


Glu Gln  Ala Leu Ser Ala Gln  Glu Gly Phe Glu Arg  Ile Lys Gln 
    1070                 1075                 1080             


Lys Tyr  Ala Glu Leu Lys Asp  Arg Leu Gly Gln Ser  Ser Met Leu 
    1085                 1090                 1095             


Gly Glu  Gln Gly Ala Arg Ile  Gln Ser Val Lys Thr  Glu Ala Glu 
    1100                 1105                 1110             


Glu Leu  Phe Gly Glu Thr Met  Glu Met Met Asp Arg  Met Lys Asp 
    1115                 1120                 1125             


Met Glu  Leu Glu Leu Leu Arg  Gly Ser Gln Ala Ile  Met Leu Arg 
    1130                 1135                 1140             


Ser Ala  Asp Leu Thr Gly Leu  Glu Lys Arg Val Glu  Gln Ile Arg 
    1145                 1150                 1155             


Asp His  Ile Asn Gly Arg Val  Leu Tyr Tyr Ala Thr  Cys Lys 
    1160                 1165                 1170         


<210>  137
<211>  5101
<212>  DNA
<213>  Homo sapiens

<400>  137
cactcctccc catcctctcc ctctgtccct ctgtccctct gaccctgcac tgtcccagca     60

ccatgggacc cacctcaggt cccagcctgc tgctcctgct actaacccac ctccccctgg    120

ctctggggag tcccatgtac tctatcatca cccccaacat cttgcggctg gagagcgagg    180

agaccatggt gctggaggcc cacgacgcgc aaggggatgt tccagtcact gttactgtcc    240

acgacttccc aggcaaaaaa ctagtgctgt ccagtgagaa gactgtgctg acccctgcca    300

ccaaccacat gggcaacgtc accttcacga tcccagccaa cagggagttc aagtcagaaa    360

aggggcgcaa caagttcgtg accgtgcagg ccaccttcgg gacccaagtg gtggagaagg    420

tggtgctggt cagcctgcag agcgggtacc tcttcatcca gacagacaag accatctaca    480

cccctggctc cacagttctc tatcggatct tcaccgtcaa ccacaagctg ctacccgtgg    540

gccggacggt catggtcaac attgagaacc cggaaggcat cccggtcaag caggactcct    600

tgtcttctca gaaccagctt ggcgtcttgc ccttgtcttg ggacattccg gaactcgtca    660

acatgggcca gtggaagatc cgagcctact atgaaaactc accacagcag gtcttctcca    720

ctgagtttga ggtgaaggag tacgtgctgc ccagtttcga ggtcatagtg gagcctacag    780

agaaattcta ctacatctat aacgagaagg gcctggaggt caccatcacc gccaggttcc    840

tctacgggaa gaaagtggag ggaactgcct ttgtcatctt cgggatccag gatggcgaac    900

agaggatttc cctgcctgaa tccctcaagc gcattccgat tgaggatggc tcgggggagg    960

ttgtgctgag ccggaaggta ctgctggacg gggtgcagaa cccccgagca gaagacctgg   1020

tggggaagtc tttgtacgtg tctgccaccg tcatcttgca ctcaggcagt gacatggtgc   1080

aggcagagcg cagcgggatc cccatcgtga cctctcccta ccagatccac ttcaccaaga   1140

cacccaagta cttcaaacca ggaatgccct ttgacctcat ggtgttcgtg acgaaccctg   1200

atggctctcc agcctaccga gtccccgtgg cagtccaggg cgaggacact gtgcagtctc   1260

taacccaggg agatggcgtg gccaaactca gcatcaacac acaccccagc cagaagccct   1320

tgagcatcac ggtgcgcacg aagaagcagg agctctcgga ggcagagcag gctaccagga   1380

ccatgcaggc tctgccctac agcaccgtgg gcaactccaa caattacctg catctctcag   1440

tgctacgtac agagctcaga cccggggaga ccctcaacgt caacttcctc ctgcgaatgg   1500

accgcgccca cgaggccaag atccgctact acacctacct gatcatgaac aagggcaggc   1560

tgttgaaggc gggacgccag gtgcgagagc ccggccagga cctggtggtg ctgcccctgt   1620

ccatcaccac cgacttcatc ccttccttcc gcctggtggc gtactacacg ctgatcggtg   1680

ccagcggcca gagggaggtg gtggccgact ccgtgtgggt ggacgtcaag gactcctgcg   1740

tgggctcgct ggtggtaaaa agcggccagt cagaagaccg gcagcctgta cctgggcagc   1800

agatgaccct gaagatagag ggtgaccacg gggcccgggt ggtactggtg gccgtggaca   1860

agggcgtgtt cgtgctgaat aagaagaaca aactgacgca gagtaagatc tgggacgtgg   1920

tggagaaggc agacatcggc tgcaccccgg gcagtgggaa ggattacgcc ggtgtcttct   1980

ccgacgcagg gctgaccttc acgagcagca gtggccagca gaccgcccag agggcagaac   2040

ttcagtgccc gcagccagcc gcccgccgac gccgttccgt gcagctcacg gagaagcgaa   2100

tggacaaagt cggcaagtac cccaaggagc tgcgcaagtg ctgcgaggac ggcatgcggg   2160

agaaccccat gaggttctcg tgccagcgcc ggacccgttt catctccctg ggcgaggcgt   2220

gcaagaaggt cttcctggac tgctgcaact acatcacaga gctgcggcgg cagcacgcgc   2280

gggccagcca cctgggcctg gccaggagta acctggatga ggacatcatt gcagaagaga   2340

acatcgtttc ccgaagtgag ttcccagaga gctggctgtg gaacgttgag gacttgaaag   2400

agccaccgaa aaatggaatc tctacgaagc tcatgaatat atttttgaaa gactccatca   2460

ccacgtggga gattctggct gtgagcatgt cggacaagaa agggatctgt gtggcagacc   2520

ccttcgaggt cacagtaatg caggacttct tcatcgacct gcggctaccc tactctgttg   2580

ttcgaaacga gcaggtggaa atccgagccg ttctctacaa ttaccggcag aaccaagagc   2640

tcaaggtgag ggtggaacta ctccacaatc cagccttctg cagcctggcc accaccaaga   2700

ggcgtcacca gcagaccgta accatccccc ccaagtcctc gttgtccgtt ccatatgtca   2760

tcgtgccgct aaagaccggc ctgcaggaag tggaagtcaa ggctgctgtc taccatcatt   2820

tcatcagtga cggtgtcagg aagtccctga aggtcgtgcc ggaaggaatc agaatgaaca   2880

aaactgtggc tgttcgcacc ctggatccag aacgcctggg ccgtgaagga gtgcagaaag   2940

aggacatccc acctgcagac ctcagtgacc aagtcccgga caccgagtct gagaccagaa   3000

ttctcctgca agggacccca gtggcccaga tgacagagga tgccgtcgac gcggaacggc   3060

tgaagcacct cattgtgacc ccctcgggct gcggggaaca gaacatgatc ggcatgacgc   3120

ccacggtcat cgctgtgcat tacctggatg aaacggagca gtgggagaag ttcggcctag   3180

agaagcggca gggggccttg gagctcatca agaaggggta cacccagcag ctggccttca   3240

gacaacccag ctctgccttt gcggccttcg tgaaacgggc acccagcacc tggctgaccg   3300

cctacgtggt caaggtcttc tctctggctg tcaacctcat cgccatcgac tcccaagtcc   3360

tctgcggggc tgttaaatgg ctgatcctgg agaagcagaa gcccgacggg gtcttccagg   3420

aggatgcgcc cgtgatacac caagaaatga ttggtggatt acggaacaac aacgagaaag   3480

acatggccct cacggccttt gttctcatct cgctgcagga ggctaaagat atttgcgagg   3540

agcaggtcaa cagcctgcca ggcagcatca ctaaagcagg agacttcctt gaagccaact   3600

acatgaacct acagagatcc tacactgtgg ccattgctgg ctatgctctg gcccagatgg   3660

gcaggctgaa ggggcctctt cttaacaaat ttctgaccac agccaaagat aagaaccgct   3720

gggaggaccc tggtaagcag ctctacaacg tggaggccac atcctatgcc ctcttggccc   3780

tactgcagct aaaagacttt gactttgtgc ctcccgtcgt gcgttggctc aatgaacaga   3840

gatactacgg tggtggctat ggctctaccc aggccacctt catggtgttc caagccttgg   3900

ctcaatacca aaaggacgcc cctgaccacc aggaactgaa ccttgatgtg tccctccaac   3960

tgcccagccg cagctccaag atcacccacc gtatccactg ggaatctgcc agcctcctgc   4020

gatcagaaga gaccaaggaa aatgagggtt tcacagtcac agctgaagga aaaggccaag   4080

gcaccttgtc ggtggtgaca atgtaccatg ctaaggccaa agatcaactc acctgtaata   4140

aattcgacct caaggtcacc ataaaaccag caccggaaac agaaaagagg cctcaggatg   4200

ccaagaacac tatgatcctt gagatctgta ccaggtaccg gggagaccag gatgccacta   4260

tgtctatatt ggacatatcc atgatgactg gctttgctcc agacacagat gacctgaagc   4320

agctggccaa tggtgttgac agatacatct ccaagtatga gctggacaaa gccttctccg   4380

ataggaacac cctcatcatc tacctggaca aggtctcaca ctctgaggat gactgtctag   4440

ctttcaaagt tcaccaatac tttaatgtag agcttatcca gcctggagca gtcaaggtct   4500

acgcctatta caacctggag gaaagctgta cccggttcta ccatccggaa aaggaggatg   4560

gaaagctgaa caagctctgc cgtgatgaac tgtgccgctg tgctgaggag aattgcttca   4620

tacaaaagtc ggatgacaag gtcaccctgg aagaacggct ggacaaggcc tgtgagccag   4680

gagtggacta tgtgtacaag acccgactgg tcaaggttca gctgtccaat gactttgacg   4740

agtacatcat ggccattgag cagaccatca agtcaggctc ggatgaggtg caggttggac   4800

agcagcgcac gttcatcagc cccatcaagt gcagagaagc cctgaagctg gaggagaaga   4860

aacactacct catgtggggt ctctcctccg atttctgggg agagaagccc aacctcagct   4920

acatcatcgg gaaggacact tgggtggagc actggcccga ggaggacgaa tgccaagacg   4980

aagagaacca gaaacaatgc caggacctcg gcgccttcac cgagagcatg gttgtctttg   5040

ggtgccccaa ctgaccacac ccccattccc ccactccaga taaagcttca gttatatctc   5100

a                                                                   5101


<210>  138
<211>  1663
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Leu Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  139
<211>  983
<212>  DNA
<213>  Homo sapiens

<400>  139
gtggaattca tggcatctac ttcgtatgac tattgcagag tgcccatgga agacggggat     60

aagcgctgta agcttctgct ggggatagga attctggtgc tcctgatcat cgtgattctg    120

ggggtgccct tgattatctt caccatcaag gccaacagcg aggcctgccg ggacggcctt    180

cgggcagtga tggagtgtcg caatgtcacc catctcctgc aacaagagct gaccgaggcc    240

cagaagggct ttcaggatgt ggaggcccag gccgccacct gcaaccacac tgtgatggcc    300

ctaatggctt ccctggatgc agagaaggcc caaggacaaa agaaagtgga ggagcttgag    360

ggagagatca ctacattaaa ccataagctt caggacgcgt ctgcagaggt ggagcgactg    420

agaagagaaa accaggtctt aagcgtgaga atcgcggaca agaagtacta ccccagctcc    480

caggactcca gctccgctgc ggcgccccag ctgctgattg tgctgctggg cctcagcgct    540

ctgctgcagt gagatcccag gaagctggca catcttggaa ggtccgtcct gctcggcttt    600

tcgcttgaac attcccttga tctcatcagt tctgagcggg tcatggggca acacggttag    660

cggggagagc acggggtagc cggagaaggg cctctggagc aggtctggag gggccatggg    720

gcagtcctgg gtgtggggac acagtcgggt tgacccaggg ctgtctccct ccagagcctc    780

cctccggaca atgagtcccc cctcttgtct cccaccctga gattgggcat ggggtgcggt    840

gtggggggca tgtgctgcct gttgttatgg gttttttttg cggggggggt tgcttttttc    900

tggggtcttt gagctccaaa aaataaacac ttcctttgag ggagagcaaa aaaaaaaaaa    960

aaaaaaaaaa aaaaaaaaaa aaa                                            983


<210>  140
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly 
1               5                   10                  15      


Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu 
            20                  25                  30          


Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala 
        35                  40                  45              


Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg 
    50                  55                  60                  


Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly 
65                  70                  75                  80  


Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met 
                85                  90                  95      


Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys 
            100                 105                 110         


Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln 
        115                 120                 125             


Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu 
    130                 135                 140                 


Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser 
145                 150                 155                 160 


Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser 
                165                 170                 175     


Ala Leu Leu Gln 
            180 


<210>  141
<211>  4119
<212>  DNA
<213>  Homo sapiens

<400>  141
ctggagagcc tgctgcccgc ccgcccgtaa aatggtcccc tcggctggac agctcgccct     60

gttcgctctg ggtattgtgt tggctgcgtg ccaggccttg gagaacagca cgtccccgct    120

gagtgcagac ccgcccgtgg ctgcagcagt ggtgtcccat tttaatgact gcccagattc    180

ccacactcag ttctgcttcc atggaacctg caggtttttg gtgcaggagg acaagccagc    240

atgtgtctgc cattctgggt acgttggtgc acgctgtgag catgcggacc tcctggccgt    300

ggtggctgcc agccagaaga agcaggccat caccgccttg gtggtggtct ccatcgtggc    360

cctggctgtc cttatcatca catgtgtgct gatacactgc tgccaggtcc gaaaacactg    420

tgagtggtgc cgggccctca tctgccggca cgagaagccc agcgccctcc tgaagggaag    480

aaccgcttgc tgccactcag aaacagtggt ctgaagagcc cagaggagga gtttggccag    540

gtggactgtg gcagatcaat aaagaaaggc ttcttcagga cagcactgcc agagatgcct    600

gggtgtgcca cagaccttcc tacttggcct gtaatcacct gtgcagcctt ttgtgggcct    660

tcaaaactct gtcaagaact ccgtctgctt ggggttattc agtgtgacct agagaagaaa    720

tcagcggacc acgatttcaa gacttgttaa aaaagaactg caaagagacg gactcctgtt    780

cacctaggtg aggtgtgtgc agcagttggt gtctgagtcc acatgtgtgc agttgtcttc    840

tgccagccat ggattccagg ctatatattt ctttttaatg ggccacctcc ccacaacaga    900

attctgccca acacaggaga tttctatagt tattgttttc tgtcatttgc ctactgggga    960

agaaagtgaa ggaggggaaa ctgtttaata tcacatgaag accctagctt taagagaagc   1020

tgtatcctct aaccacgaga ctctcaacca gcccaacatc ttccatggac acatgacatt   1080

gaagaccatc ccaagctatc gccacccttg gagatgatgt cttatttatt agatggataa   1140

tggttttatt tttaatctct taagtcaatg taaaaagtat aaaacccctt cagacttcta   1200

cattaatgat gtatgtgttg ctgactgaaa agctatactg attagaaatg tctggcctct   1260

tcaagacagc taaggcttgg gaaaagtctt ccagggtgcg gagatggaac cagaggctgg   1320

gttactggta ggaataaagg taggggttca gaaatggtgc cattgaagcc acaaagccgg   1380

taaatgcctc aatacgttct gggagaaaac ttagcaaatc catcagcagg gatctgtccc   1440

ctctgttggg gagagaggaa gagtgtgtgt gtctacacag gataaaccca atacatattg   1500

tactgctcag tgattaaatg ggttcacttc ctcgtgagcc ctcggtaagt atgtttagaa   1560

atagaacatt agccacgagc cataggcatt tcaggccaaa tccatgaaag ggggaccagt   1620

catttatttt ccattttgtt gcttggttgg tttgttgctt tatttttaaa aggagaagtt   1680

taactttgct atttattttc gagcactagg aaaactattc cagtaatttt tttttcctca   1740

tttccattca ggatgccggc tttattaaca aaaactctaa caagtcacct ccactatgtg   1800

ggtcttcctt tcccctcaag agaaggagca attgttcccc tgacatctgg gtccatctga   1860

cccatggggc ctgcctgtga gaaacagtgg gtcccttcaa atacatagtg gatagctcat   1920

ccctaggaat tttcattaaa atttggaaac agagtaatga agaaataata tataaactcc   1980

ttatgtgagg aaatgctact aatatctgaa aagtgaaaga tttctatgta ttaactctta   2040

agtgcaccta gcttattaca tcgtgaaagg tacatttaaa atatgttaaa ttggcttgaa   2100

attttcagag aattttgtct tcccctaatt cttcttcctt ggtctggaag aacaatttct   2160

atgaattttc tctttatttt ttttttataa ttcagacaat tctatgaccc gtgtcttcat   2220

ttttggcact cttatttaac aatgccacac ctgaagcact tggatctgtt cagagctgac   2280

cccctagcaa cgtagttgac acagctccag gtttttaaat tactaaaata agttcaagtt   2340

tacatccctt gggccagata tgtgggttga ggcttgactg tagcatcctg cttagagacc   2400

aatcaatgga cactggtttt tagacctcta tcaatcagta gttagcatcc aagagacttt   2460

gcagaggcgt aggaatgagg ctggacagat ggcggaacga gaggttccct gcgaagactt   2520

gagatttagt gtctgtgaat gttctagttc ctaggtccag caagtcacac ctgccagtgc   2580

cctcatcctt atgcctgtaa cacacatgca gtgagaggcc tcacatatac gcctccctag   2640

aagtgccttc caagtcagtc ctttggaaac cagcaggtct gaaaaagagg ctgcatcaat   2700

gcaagcctgg ttggaccatt gtccatgcct caggatagaa cagcctggct tatttgggga   2760

tttttcttct agaaatcaaa tgactgataa gcattggctc cctctgccat ttaatggcaa   2820

tggtagtctt tggttagctg caaaaatact ccatttcaag ttaaaaatgc atcttctaat   2880

ccatctctgc aagctccctg tgtttccttg ccctttagaa aatgaattgt tcactacaat   2940

tagagaatca tttaacatcc tgacctggta agctgccaca cacctggcag tggggagcat   3000

cgctgtttcc aatggctcag gagacaatga aaagccccca tttaaaaaaa taacaaacat   3060

tttttaaaag gcctccaata ctcttatgga gcctggattt ttcccactgc tctacaggct   3120

gtgacttttt ttaagcatcc tgacaggaaa tgttttcttc tacatggaaa gatagacagc   3180

agccaaccct gatctggaag acagggcccc ggctggacac acgtggaacc aagccaggga   3240

tgggctggcc attgtgtccc cgcaggagag atgggcagaa tggccctaga gttcttttcc   3300

ctgagaaagg agaaaaagat gggattgcca ctcacccacc cacactggta agggaggaga   3360

atttgtgctt ctggagcttc tcaagggatt gtgttttgca ggtacagaaa actgcctgtt   3420

atcttcaagc caggttttcg agggcacatg ggtcaccagt tgctttttca gtcaatttgg   3480

ccgggatgga ctaatgaggc tctaacactg ctcaggagac ccctgccctc tagttggttc   3540

tgggctttga tctcttccaa cctgcccagt cacagaagga ggaatgactc aaatgcccaa   3600

aaccaagaac acattgcaga agtaagacaa acatgtatat ttttaaatgt tctaacataa   3660

gacctgttct ctctagccat tgatttacca ggctttctga aagatctagt ggttcacaca   3720

gagagagaga gagtactgaa aaagcaactc ctcttcttag tcttaataat ttactaaaat   3780

ggtcaacttt tcattatctt tattataata aacctgatgc ttttttttag aactccttac   3840

tctgatgtct gtatatgttg cactgaaaag gttaatattt aatgttttaa tttattttgt   3900

gtggtaagtt aattttgatt tctgtaatgt gttaatgtga ttagcagtta ttttccttaa   3960

tatctgaatt atacttaaag agtagtgagc aatataagac gcaattgtgt ttttcagtaa   4020

tgtgcattgt tattgagttg tactgtacct tatttggaag gatgaaggaa tgaacctttt   4080

tttcctaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                          4119


<210>  142
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                  15      


Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Ala 
            20                  25                  30          


Asp Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro 
        35                  40                  45              


Asp Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val 
    50                  55                  60                  


Gln Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala 
65                  70                  75                  80  


Arg Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys 
                85                  90                  95      


Lys Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala 
            100                 105                 110         


Val Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys 
        115                 120                 125             


His Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser 
    130                 135                 140                 


Ala Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                 150                 155                 160 


<210>  143
<211>  1794
<212>  DNA
<213>  Homo sapiens

<400>  143
cccgcgccac cggcccgcgc cccgccatgg aggacctgga tgccctgctc tctgacctgg     60

agactaccac ctcgcacatg ccaaggtcag gggctcccaa agagcgccct gcggagcctc    120

tcacccctcc cccatcctat ggccaccagc cacagacagg gtctggggag tcttcaggag    180

cctcggggga caaggaccac ctgtacagca cggtatgcaa gcctcggtcc ccaaagcctg    240

cagccccggc ggcccctcca ttctcctctt ccagcggtgt cttgggtacc gggctctgtg    300

agctagatcg gttgcttcag gaacttaatg ccactcagtt caacatcaca gatgaaatca    360

tgtctcagtt cccatctagc aaggtggctt caggagagca gaaggaggac cagtctgaag    420

ataagaaaag acccagcctc ccttccagcc cgtctcctgg cctcccaaag gcttctgcca    480

cctcagccac tctggagctg gatagactga tggcctcact ctctgacttc cgcgttcaaa    540

accatcttcc agcctctggg ccaactcagc caccggtggt gagctccaca aatgagggct    600

ccccatcccc accagagccg actggcaagg gcagcctaga caccatgctg gggctgctgc    660

agtccgacct cagccgccgg ggtgttccca cccaggccaa aggcctctgt ggctcctgca    720

ataaacctat tgctgggcaa gtggtgacgg ctctgggccg cgcctggcac cccgagcact    780

tcgtttgcgg aggctgttcc accgccctgg gaggcagcag cttcttcgag aaggatggag    840

cccccttctg ccccgagtgc tactttgagc gcttctcgcc aagatgtggc ttctgcaacc    900

agcccatccg acacaagatg gtgaccgcct tgggcactca ctggcaccca gagcatttct    960

gctgcgtcag ttgcggggag cccttcggag atgagggttt ccacgagcgc gagggccgcc   1020

cctactgccg ccgggacttc ctgcagctgt tcgccccgcg ctgccagggc tgccagggcc   1080

ccatcctgga taactacatc tcggcgctca gcgcgctctg gcacccggac tgtttcgtct   1140

gcagggaatg cttcgcgccc ttctcgggag gcagcttttt cgagcacgag ggccgcccgt   1200

tgtgcgagaa ccacttccac gcacgacgcg gctcgctgtg cgccacgtgt ggcctccctg   1260

tgaccggccg ctgcgtgtcg gccctgggtc gccgcttcca cccggaccac ttcacatgca   1320

ccttctgcct gcgcccgctc accaaggggt ccttccagga gcgcgccggc aagccctact   1380

gccagccctg cttcctgaag ctcttcggct gacagcccgc tcggctcgcc ctctcccccg   1440

gaggccgcgc cctcccggaa aagccgggtc ctccagaccc cgaggccttg ctctcagagc   1500

gggaggcccc acccactgga gagccccgcc cctaaggtac tatgagtcct caggggtcaa   1560

gttcagaaac ggcccagcca gacctaaacc cacacgccca caaagtggat tgcacacaga   1620

caagaactcc cgtgcgggcc tccactctat tcccaccctt gagggagccc ccttactggg   1680

ggagggtcct tgcaattcca gcgaatcgga ggccaggcca ggacgtcctt gctccctgca   1740

ccctcactgt tctgtgcact ttttctacct acataaacac acgcattcca cctc         1794


<210>  144
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Glu Asp Leu Asp Ala Leu Leu Ser Asp Leu Glu Thr Thr Thr Ser 
1               5                   10                  15      


His Met Pro Arg Ser Gly Ala Pro Lys Glu Arg Pro Ala Glu Pro Leu 
            20                  25                  30          


Thr Pro Pro Pro Ser Tyr Gly His Gln Pro Gln Thr Gly Ser Gly Glu 
        35                  40                  45              


Ser Ser Gly Ala Ser Gly Asp Lys Asp His Leu Tyr Ser Thr Val Cys 
    50                  55                  60                  


Lys Pro Arg Ser Pro Lys Pro Ala Ala Pro Ala Ala Pro Pro Phe Ser 
65                  70                  75                  80  


Ser Ser Ser Gly Val Leu Gly Thr Gly Leu Cys Glu Leu Asp Arg Leu 
                85                  90                  95      


Leu Gln Glu Leu Asn Ala Thr Gln Phe Asn Ile Thr Asp Glu Ile Met 
            100                 105                 110         


Ser Gln Phe Pro Ser Ser Lys Val Ala Ser Gly Glu Gln Lys Glu Asp 
        115                 120                 125             


Gln Ser Glu Asp Lys Lys Arg Pro Ser Leu Pro Ser Ser Pro Ser Pro 
    130                 135                 140                 


Gly Leu Pro Lys Ala Ser Ala Thr Ser Ala Thr Leu Glu Leu Asp Arg 
145                 150                 155                 160 


Leu Met Ala Ser Leu Ser Asp Phe Arg Val Gln Asn His Leu Pro Ala 
                165                 170                 175     


Ser Gly Pro Thr Gln Pro Pro Val Val Ser Ser Thr Asn Glu Gly Ser 
            180                 185                 190         


Pro Ser Pro Pro Glu Pro Thr Gly Lys Gly Ser Leu Asp Thr Met Leu 
        195                 200                 205             


Gly Leu Leu Gln Ser Asp Leu Ser Arg Arg Gly Val Pro Thr Gln Ala 
    210                 215                 220                 


Lys Gly Leu Cys Gly Ser Cys Asn Lys Pro Ile Ala Gly Gln Val Val 
225                 230                 235                 240 


Thr Ala Leu Gly Arg Ala Trp His Pro Glu His Phe Val Cys Gly Gly 
                245                 250                 255     


Cys Ser Thr Ala Leu Gly Gly Ser Ser Phe Phe Glu Lys Asp Gly Ala 
            260                 265                 270         


Pro Phe Cys Pro Glu Cys Tyr Phe Glu Arg Phe Ser Pro Arg Cys Gly 
        275                 280                 285             


Phe Cys Asn Gln Pro Ile Arg His Lys Met Val Thr Ala Leu Gly Thr 
    290                 295                 300                 


His Trp His Pro Glu His Phe Cys Cys Val Ser Cys Gly Glu Pro Phe 
305                 310                 315                 320 


Gly Asp Glu Gly Phe His Glu Arg Glu Gly Arg Pro Tyr Cys Arg Arg 
                325                 330                 335     


Asp Phe Leu Gln Leu Phe Ala Pro Arg Cys Gln Gly Cys Gln Gly Pro 
            340                 345                 350         


Ile Leu Asp Asn Tyr Ile Ser Ala Leu Ser Ala Leu Trp His Pro Asp 
        355                 360                 365             


Cys Phe Val Cys Arg Glu Cys Phe Ala Pro Phe Ser Gly Gly Ser Phe 
    370                 375                 380                 


Phe Glu His Glu Gly Arg Pro Leu Cys Glu Asn His Phe His Ala Arg 
385                 390                 395                 400 


Arg Gly Ser Leu Cys Ala Thr Cys Gly Leu Pro Val Thr Gly Arg Cys 
                405                 410                 415     


Val Ser Ala Leu Gly Arg Arg Phe His Pro Asp His Phe Thr Cys Thr 
            420                 425                 430         


Phe Cys Leu Arg Pro Leu Thr Lys Gly Ser Phe Gln Glu Arg Ala Gly 
        435                 440                 445             


Lys Pro Tyr Cys Gln Pro Cys Phe Leu Lys Leu Phe Gly 
    450                 455                 460     


<210>  145
<211>  6719
<212>  DNA
<213>  Homo sapiens

<400>  145
tcggcgggaa gcggcgatcc tgccaccggg aggtgtggaa gagccgggta gattctggct     60

acattggaga ttggttgctt tctaaaactg aaggagaagc ccatgaagag atggtggatt    120

ctcactgagt tttgactagc ggaagaaaag agagagttca agtggatggc cttgaggact    180

tgaaaagctg agatatgatg attttgaagt catttcacat cgaagccatg atttaaatat    240

cggcgttaag atttcaacaa gaaaaactta agcttccttg gattcccacg tcaaaggaaa    300

gtttcaagct ttcagaagga gttctcactc gaagataaag aacagctcgc taaccacgaa    360

agaggaatcg atgctcagct tttagttgca cttcctaaag ttgcagaatt aagacaaatc    420

tttgaaccaa agaagaaaga attcttagaa atgaaaagaa aagaaagaat tgccaggcgc    480

ctggaaggga ttgaaaatga cactcagccc atcctcttgc agagctgcac aggattggtg    540

actcaccgcc tgctggagga agacacccct cgatacatga gagccagcga ccctgccagc    600

ccccacatcg gccgatcaaa tgaagaggag gaaacttctg attcttctct agaaaagcaa    660

actcgatcca aatactgcac agaaacctcc ggtgtccacg gtgactcacc ctatggttcg    720

ggtaccatgg acacccacag tctggagtcc aaagccgaaa gaattgcaag gtacaaagca    780

gaaagaaggc gacagctggc agagaagtat gggctgactc tggatcccga ggccgactcc    840

gagtatttat cccgctatac caagtccagg aaggagcctg atgctgtcga gaagcgggga    900

ggaaaaagtg acaaacagga agagtcaagc agagatgcga gttctctgta ccccgggacc    960

gagacgatgg ggctcaggac ctgtgccggt gaatccaagg actatgccct ccatgtgggt   1020

gacggctctt ccgacccgga ggtgctgctg aacatagaaa accaaagacg aggtcaagag   1080

ctgagtgcca cccggcaggc ccatgacctg tccccagcag ccgagagttc ctcgaccttc   1140

tctttctctg ggcgagactc ctccttcact gaagtgccac ggtcccccaa gcacgcccac   1200

agctcctccc tgcagcaggc agcctcccgg agcccctcct ttggtgaccc acagctatcc   1260

cctgaggccc gacccaggtg cacttcacat tcagaaacgc caactgtcga tgatgaagaa   1320

aaggtggatg aacgagccaa gctgagcgtc gccgccaaga ggttgctttt cagggagatg   1380

gaaaaatctt ttgatgaaca aaatgttcca aagcgacgct caagaaacac agctgtggag   1440

cagaggctac gccgtctgca ggacaggtcc ctcacccagc ccatcaccac tgaagaggtg   1500

gtcatcgcag ccacattgca ggcctctgct caccaaaagg ccttagccaa ggaccagaca   1560

aatgagggca aagagcttgc tgagcaagga gaacctgatt cctccactct aagcttggcc   1620

gaaaagttgg ccttgtttaa caaattgtcc cagccagtct caaaagcgat ttctacccgg   1680

aacagaatag acacgagaca gaggagaatg aacgctcgct atcaaactca gccagtcaca   1740

ctgggagagg tggagcaggt gcagagtgga aagctcattc ctttctcacc tgccgtgaac   1800

acatcagtgt ctaccgtagc atccacggtt gctccaatgt atgccggaga tcttcgcaca   1860

aagccacctc ttgaccacaa tgcaagtgcc actgactata agttttcttc ttcaatagaa   1920

aattcggact ctccagttag aagcattctg aaatcgcaag cttggcagcc tttggtagag   1980

ggtagcgaga acaagggaat gttgagagaa tatggagaga cagaaagcaa gagagctttg   2040

acaggtcgag acagtgggat ggagaagtat gggtcctttg aggaagcaga agcatcctac   2100

cccatcctga accgagccag ggaaggagac agccataagg aatctaaata tgctgttccc   2160

agaagaggaa gcctggaacg ggcgaaccct cccatcaccc acctcgggga tgaaccgaag   2220

gaattttcca tggctaaaat gaatgcacaa ggaaacttgg acttgaggga caggctgccc   2280

tttgaagaga aggtggaggt ggagaatgtt atgaaaagga agttttcact aagagcggca   2340

gagttcgggg agcccacttc cgagcagacg gggacagctg ctgggaaaac tattgctcaa   2400

accacagccc ccgtgtcctg gaagccccag gattcttcgg aacagccaca ggagaagctc   2460

tgcaagaatc catgtgcgat gtttgctgct ggagagatca aaacgccgac aggggagggc   2520

cttcttgact cacccagcaa aaccatgtct attaaagaaa gattggcact gttgaagaaa   2580

agcggggagg aagattggag aaacagactc agcaggaggc aggagggcgg caaggcgccg   2640

gccagcagcc tgcacaccca ggaagcaggg cggtccctca tcaagaagcg ggtcacagaa   2700

agtcgagaga gccaaatgac gattgaggag aggaagcagc tcatcactgt gagagaggag   2760

gcctggaaga cgagaggcag aggagcggcc aacgactcga cccagttcac tgtggctggc   2820

aggatggtga agaaaggttt ggcgtcacct actgccataa ccccagtagc ctcagccatt   2880

tgcggtaaaa caagaggcac cacacccgtt tccaaacccc tggaagatat cgaagccaga   2940

ccagatatgc agttagaatc ggacctgaag ttggacaggc tggaaacctt tctaagaagg   3000

ctgaataaca aagttggcgg gatgcacgaa acggtgctca ctgtcaccgg caaatctgtg   3060

aaggaggtga tgaagccaga tgatgatgaa acctttgcca aattttaccg cagcgtggat   3120

tataatatgc caagaagtcc tgtggagatg gatgaggact tcgatgtcat tttcgatcct   3180

tatgcaccca aattgacgtc ttccgtggcc gagcacaagc gggcagttag gcccaagcgc   3240

cgggttcagg cctccaaaaa ccccctgaaa atgctggcgg caagagaaga tctccttcag   3300

gaatacactg agcagagatt aaacgttgcc ttcatggagt caaagcggat gaaagtagaa   3360

aagatgtctt ccaactccaa cttctcagaa gtcaccctgg cgggtttagc cagtaaagaa   3420

aacttcagca acgtcagcct gcggagcgtc aacctgacgg aacagaactc taacaacagc   3480

gccgtgccct acaagaggct gatgctgttg cagattaaag gaagaagaca tgtgcagacc   3540

aggctggtgg aacctcgagc ttcggcgctc aacagtgggg actgcttcct cctgctctct   3600

ccccactgct gcttcctgtg ggtaggagag tttgcaaacg tcatagaaaa ggcgaaggcc   3660

tcagaacttg caactttaat tcagacaaag agggaacttg gttgtagagc tacttatatc   3720

caaaccattg aagaaggaat taatacacac actcatgcag ccaaagactt ctggaagctt   3780

ctgggtggcc aaaccagtta ccaatctgct ggagacccaa aagaagatga actctatgaa   3840

gcagccataa tagaaactaa ctgcatttac cgtctcatgg atgacaaact tgttcctgat   3900

gacgactact gggggaaaat tccgaagtgc tcccttctgc aacccaaaga ggtactggtg   3960

tttgattttg gtagtgaagt ttacgtatgg catgggaaag aagtcacatt agcacaacga   4020

aaaatagcat ttcagctggc aaagcactta tggaatggaa cctttgacta tgagaactgt   4080

gacatcaatc ccctggatcc tggagaatgc aatccgctta tccccagaaa aggacagggg   4140

cggcccgact gggcgatatt tgggagactt actgaacaca atgagacgat tttgttcaaa   4200

gagaagtttc tggattggac ggaactgaag agatcgaatg agaagaaccc cggggaactt   4260

gcccagcaca aggaagaccc caggactgat gtcaaggcat acgatgtgac acggatggtg   4320

tccatgcccc agacgacagc aggcaccatc ctggacggag tgaacgtcgg ccgtggctat   4380

ggcctggtgg aaggacacga caggaggcag tttgagatca ccagcgtttc cgtggatgtc   4440

tggcacatcc tggaattcga ctatagcagg ctccccaaac aaagcatcgg gcagttccat   4500

gagggggatg cctatgtggt caagtggaag ttcatggtga gcacggcagt gggaagtcgc   4560

cagaagggag agcactcggt gagggcagcc ggcaaagaga agtgcgtcta cttcttctgg   4620

caaggccggc actccaccgt gagtgagaag ggcacgtcgg cgctgatgac ggtggagctg   4680

gacgaggaaa ggggggccca ggtccaggtt ctccagggaa aggagccccc ctgtttcctg   4740

cagtgtttcc agggggggat ggtggtgcac tcggggaggc gggaagagga agaagaaaat   4800

gtgcaaagtg agtggcggct gtactgcgtg cgtggagagg tgcccgtgga agggaatttg   4860

ctggaagtgg cctgtcactg tagcagcctg aggtccagaa cttccatggt ggtgcttaac   4920

gtcaacaagg ccctcatcta cctgtggcac ggatgcaaag cccaggccca cacgaaggag   4980

gtcggaagga ccgctgcgaa caagatcaag gaacaatgtc ccctggaagc aggactgcat   5040

agtagcagca aagtcacaat acacgagtgt gatgaaggct ccgagccact cggattctgg   5100

gatgccttag gaaggagaga caggaaagcc tacgattgca tgcttcaaga tcctggaagt   5160

tttaacttcg cgccccgcct gttcatcctc agcagctcct ctggggattt tgcagccaca   5220

gagtttgtgt accctgcccg agccccctct gtggtcagtt ccatgccctt cctgcaggaa   5280

gatctgtaca gcgcgcccca gccagcactt ttccttgttg acaatcacca cgaggtgtac   5340

ctctggcaag gctggtggcc catcgagaac aagatcactg gttccgcccg catccgctgg   5400

gcctccgacc ggaagagtgc gatggagact gtgctccagt actgcaaagg aaaaaatctc   5460

aagaaaccag cccccaagtc ttaccttatc cacgctggtc tggagcccct gacattcacc   5520

aatatgtttc ccagctggga gcacagagag gacatcgctg agatcacaga gatggacacg   5580

gaagtttcca atcagatcac cctcgtggaa gacgtcttag ccaagctctg taaaaccatt   5640

tacccgctgg ccgacctcct ggccaggcca ctcccggagg gggtcgatcc tctgaagctt   5700

gagatctatc tcaccgacga agacttcgag tttgcactag acatgacgag ggatgaatac   5760

aacgccctgc ccgcctggaa gcaggtgaac ctgaagaaag caaaaggcct gttctgagtg   5820

gggagacgcc agaggagcct cacggtcacg tccaacaaca ccactgcacc agggaaatgg   5880

atatatattt ttggactggt gtttttcaca aagtattttt caatcagagt tttcagaacc   5940

tgacattgtt aaagatactg cttgtcccgg agttgtgtat tttgtaaatg ttcaagggaa   6000

ctgtttggaa acttctttcc accattcagg aggttatcag aattaataaa agtatctgtt   6060

atgtgcactt aagccgcagc tgctatagat agcactgcct tcttgttcca gctaggcaat   6120

gccttttttt ttttttttga agcagttctc tttataaagt gttattttga tagtttgtgg   6180

attctaaaat atatatatat ttatataaac accatataag tcaaatatgt atttaacaaa   6240

gcaatatgta ttcattcact ttcaagattt gttttggtgt caaaataaca tgaaaaggta   6300

gatggagttg cttctgttga attagctctg ccaccaatat gtatcttcat acacgtttgg   6360

aaatgtttcc tgcagcatta ggtatgactt gttctgagta ctgcttccgg tgctaaaatg   6420

aacaaagaat ttgtacttaa tggcatggac tctggagaat ctatgcgaat caacctttct   6480

accttaatat ctccccaaaa atgtatagtg ccttgttttt atgtacagtt tatatacaga   6540

aaagtttgct ctgcattttt gatgatggtt tggaacatta tctacaattt tactctcaaa   6600

tagtcaaaat aaaaacatct caatttctaa taccggttgt aaacaaacag tacacatgtc   6660

attttgtgat ataggactcc caaataaaag tatcagaata aacacaacaa ttaactggt    6719


<210>  146
<211>  1788
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Lys Arg Lys Glu Arg Ile Ala Arg Arg Leu Glu Gly Ile Glu Asn 
1               5                   10                  15      


Asp Thr Gln Pro Ile Leu Leu Gln Ser Cys Thr Gly Leu Val Thr His 
            20                  25                  30          


Arg Leu Leu Glu Glu Asp Thr Pro Arg Tyr Met Arg Ala Ser Asp Pro 
        35                  40                  45              


Ala Ser Pro His Ile Gly Arg Ser Asn Glu Glu Glu Glu Thr Ser Asp 
    50                  55                  60                  


Ser Ser Leu Glu Lys Gln Thr Arg Ser Lys Tyr Cys Thr Glu Thr Ser 
65                  70                  75                  80  


Gly Val His Gly Asp Ser Pro Tyr Gly Ser Gly Thr Met Asp Thr His 
                85                  90                  95      


Ser Leu Glu Ser Lys Ala Glu Arg Ile Ala Arg Tyr Lys Ala Glu Arg 
            100                 105                 110         


Arg Arg Gln Leu Ala Glu Lys Tyr Gly Leu Thr Leu Asp Pro Glu Ala 
        115                 120                 125             


Asp Ser Glu Tyr Leu Ser Arg Tyr Thr Lys Ser Arg Lys Glu Pro Asp 
    130                 135                 140                 


Ala Val Glu Lys Arg Gly Gly Lys Ser Asp Lys Gln Glu Glu Ser Ser 
145                 150                 155                 160 


Arg Asp Ala Ser Ser Leu Tyr Pro Gly Thr Glu Thr Met Gly Leu Arg 
                165                 170                 175     


Thr Cys Ala Gly Glu Ser Lys Asp Tyr Ala Leu His Val Gly Asp Gly 
            180                 185                 190         


Ser Ser Asp Pro Glu Val Leu Leu Asn Ile Glu Asn Gln Arg Arg Gly 
        195                 200                 205             


Gln Glu Leu Ser Ala Thr Arg Gln Ala His Asp Leu Ser Pro Ala Ala 
    210                 215                 220                 


Glu Ser Ser Ser Thr Phe Ser Phe Ser Gly Arg Asp Ser Ser Phe Thr 
225                 230                 235                 240 


Glu Val Pro Arg Ser Pro Lys His Ala His Ser Ser Ser Leu Gln Gln 
                245                 250                 255     


Ala Ala Ser Arg Ser Pro Ser Phe Gly Asp Pro Gln Leu Ser Pro Glu 
            260                 265                 270         


Ala Arg Pro Arg Cys Thr Ser His Ser Glu Thr Pro Thr Val Asp Asp 
        275                 280                 285             


Glu Glu Lys Val Asp Glu Arg Ala Lys Leu Ser Val Ala Ala Lys Arg 
    290                 295                 300                 


Leu Leu Phe Arg Glu Met Glu Lys Ser Phe Asp Glu Gln Asn Val Pro 
305                 310                 315                 320 


Lys Arg Arg Ser Arg Asn Thr Ala Val Glu Gln Arg Leu Arg Arg Leu 
                325                 330                 335     


Gln Asp Arg Ser Leu Thr Gln Pro Ile Thr Thr Glu Glu Val Val Ile 
            340                 345                 350         


Ala Ala Thr Leu Gln Ala Ser Ala His Gln Lys Ala Leu Ala Lys Asp 
        355                 360                 365             


Gln Thr Asn Glu Gly Lys Glu Leu Ala Glu Gln Gly Glu Pro Asp Ser 
    370                 375                 380                 


Ser Thr Leu Ser Leu Ala Glu Lys Leu Ala Leu Phe Asn Lys Leu Ser 
385                 390                 395                 400 


Gln Pro Val Ser Lys Ala Ile Ser Thr Arg Asn Arg Ile Asp Thr Arg 
                405                 410                 415     


Gln Arg Arg Met Asn Ala Arg Tyr Gln Thr Gln Pro Val Thr Leu Gly 
            420                 425                 430         


Glu Val Glu Gln Val Gln Ser Gly Lys Leu Ile Pro Phe Ser Pro Ala 
        435                 440                 445             


Val Asn Thr Ser Val Ser Thr Val Ala Ser Thr Val Ala Pro Met Tyr 
    450                 455                 460                 


Ala Gly Asp Leu Arg Thr Lys Pro Pro Leu Asp His Asn Ala Ser Ala 
465                 470                 475                 480 


Thr Asp Tyr Lys Phe Ser Ser Ser Ile Glu Asn Ser Asp Ser Pro Val 
                485                 490                 495     


Arg Ser Ile Leu Lys Ser Gln Ala Trp Gln Pro Leu Val Glu Gly Ser 
            500                 505                 510         


Glu Asn Lys Gly Met Leu Arg Glu Tyr Gly Glu Thr Glu Ser Lys Arg 
        515                 520                 525             


Ala Leu Thr Gly Arg Asp Ser Gly Met Glu Lys Tyr Gly Ser Phe Glu 
    530                 535                 540                 


Glu Ala Glu Ala Ser Tyr Pro Ile Leu Asn Arg Ala Arg Glu Gly Asp 
545                 550                 555                 560 


Ser His Lys Glu Ser Lys Tyr Ala Val Pro Arg Arg Gly Ser Leu Glu 
                565                 570                 575     


Arg Ala Asn Pro Pro Ile Thr His Leu Gly Asp Glu Pro Lys Glu Phe 
            580                 585                 590         


Ser Met Ala Lys Met Asn Ala Gln Gly Asn Leu Asp Leu Arg Asp Arg 
        595                 600                 605             


Leu Pro Phe Glu Glu Lys Val Glu Val Glu Asn Val Met Lys Arg Lys 
    610                 615                 620                 


Phe Ser Leu Arg Ala Ala Glu Phe Gly Glu Pro Thr Ser Glu Gln Thr 
625                 630                 635                 640 


Gly Thr Ala Ala Gly Lys Thr Ile Ala Gln Thr Thr Ala Pro Val Ser 
                645                 650                 655     


Trp Lys Pro Gln Asp Ser Ser Glu Gln Pro Gln Glu Lys Leu Cys Lys 
            660                 665                 670         


Asn Pro Cys Ala Met Phe Ala Ala Gly Glu Ile Lys Thr Pro Thr Gly 
        675                 680                 685             


Glu Gly Leu Leu Asp Ser Pro Ser Lys Thr Met Ser Ile Lys Glu Arg 
    690                 695                 700                 


Leu Ala Leu Leu Lys Lys Ser Gly Glu Glu Asp Trp Arg Asn Arg Leu 
705                 710                 715                 720 


Ser Arg Arg Gln Glu Gly Gly Lys Ala Pro Ala Ser Ser Leu His Thr 
                725                 730                 735     


Gln Glu Ala Gly Arg Ser Leu Ile Lys Lys Arg Val Thr Glu Ser Arg 
            740                 745                 750         


Glu Ser Gln Met Thr Ile Glu Glu Arg Lys Gln Leu Ile Thr Val Arg 
        755                 760                 765             


Glu Glu Ala Trp Lys Thr Arg Gly Arg Gly Ala Ala Asn Asp Ser Thr 
    770                 775                 780                 


Gln Phe Thr Val Ala Gly Arg Met Val Lys Lys Gly Leu Ala Ser Pro 
785                 790                 795                 800 


Thr Ala Ile Thr Pro Val Ala Ser Ala Ile Cys Gly Lys Thr Arg Gly 
                805                 810                 815     


Thr Thr Pro Val Ser Lys Pro Leu Glu Asp Ile Glu Ala Arg Pro Asp 
            820                 825                 830         


Met Gln Leu Glu Ser Asp Leu Lys Leu Asp Arg Leu Glu Thr Phe Leu 
        835                 840                 845             


Arg Arg Leu Asn Asn Lys Val Gly Gly Met His Glu Thr Val Leu Thr 
    850                 855                 860                 


Val Thr Gly Lys Ser Val Lys Glu Val Met Lys Pro Asp Asp Asp Glu 
865                 870                 875                 880 


Thr Phe Ala Lys Phe Tyr Arg Ser Val Asp Tyr Asn Met Pro Arg Ser 
                885                 890                 895     


Pro Val Glu Met Asp Glu Asp Phe Asp Val Ile Phe Asp Pro Tyr Ala 
            900                 905                 910         


Pro Lys Leu Thr Ser Ser Val Ala Glu His Lys Arg Ala Val Arg Pro 
        915                 920                 925             


Lys Arg Arg Val Gln Ala Ser Lys Asn Pro Leu Lys Met Leu Ala Ala 
    930                 935                 940                 


Arg Glu Asp Leu Leu Gln Glu Tyr Thr Glu Gln Arg Leu Asn Val Ala 
945                 950                 955                 960 


Phe Met Glu Ser Lys Arg Met Lys Val Glu Lys Met Ser Ser Asn Ser 
                965                 970                 975     


Asn Phe Ser Glu Val Thr Leu Ala Gly Leu Ala Ser Lys Glu Asn Phe 
            980                 985                 990         


Ser Asn Val Ser Leu Arg Ser Val  Asn Leu Thr Glu Gln  Asn Ser Asn 
        995                 1000                 1005             


Asn Ser  Ala Val Pro Tyr Lys  Arg Leu Met Leu Leu  Gln Ile Lys 
    1010                 1015                 1020             


Gly Arg  Arg His Val Gln Thr  Arg Leu Val Glu Pro  Arg Ala Ser 
    1025                 1030                 1035             


Ala Leu  Asn Ser Gly Asp Cys  Phe Leu Leu Leu Ser  Pro His Cys 
    1040                 1045                 1050             


Cys Phe  Leu Trp Val Gly Glu  Phe Ala Asn Val Ile  Glu Lys Ala 
    1055                 1060                 1065             


Lys Ala  Ser Glu Leu Ala Thr  Leu Ile Gln Thr Lys  Arg Glu Leu 
    1070                 1075                 1080             


Gly Cys  Arg Ala Thr Tyr Ile  Gln Thr Ile Glu Glu  Gly Ile Asn 
    1085                 1090                 1095             


Thr His  Thr His Ala Ala Lys  Asp Phe Trp Lys Leu  Leu Gly Gly 
    1100                 1105                 1110             


Gln Thr  Ser Tyr Gln Ser Ala  Gly Asp Pro Lys Glu  Asp Glu Leu 
    1115                 1120                 1125             


Tyr Glu  Ala Ala Ile Ile Glu  Thr Asn Cys Ile Tyr  Arg Leu Met 
    1130                 1135                 1140             


Asp Asp  Lys Leu Val Pro Asp  Asp Asp Tyr Trp Gly  Lys Ile Pro 
    1145                 1150                 1155             


Lys Cys  Ser Leu Leu Gln Pro  Lys Glu Val Leu Val  Phe Asp Phe 
    1160                 1165                 1170             


Gly Ser  Glu Val Tyr Val Trp  His Gly Lys Glu Val  Thr Leu Ala 
    1175                 1180                 1185             


Gln Arg  Lys Ile Ala Phe Gln  Leu Ala Lys His Leu  Trp Asn Gly 
    1190                 1195                 1200             


Thr Phe  Asp Tyr Glu Asn Cys  Asp Ile Asn Pro Leu  Asp Pro Gly 
    1205                 1210                 1215             


Glu Cys  Asn Pro Leu Ile Pro  Arg Lys Gly Gln Gly  Arg Pro Asp 
    1220                 1225                 1230             


Trp Ala  Ile Phe Gly Arg Leu  Thr Glu His Asn Glu  Thr Ile Leu 
    1235                 1240                 1245             


Phe Lys  Glu Lys Phe Leu Asp  Trp Thr Glu Leu Lys  Arg Ser Asn 
    1250                 1255                 1260             


Glu Lys  Asn Pro Gly Glu Leu  Ala Gln His Lys Glu  Asp Pro Arg 
    1265                 1270                 1275             


Thr Asp  Val Lys Ala Tyr Asp  Val Thr Arg Met Val  Ser Met Pro 
    1280                 1285                 1290             


Gln Thr  Thr Ala Gly Thr Ile  Leu Asp Gly Val Asn  Val Gly Arg 
    1295                 1300                 1305             


Gly Tyr  Gly Leu Val Glu Gly  His Asp Arg Arg Gln  Phe Glu Ile 
    1310                 1315                 1320             


Thr Ser  Val Ser Val Asp Val  Trp His Ile Leu Glu  Phe Asp Tyr 
    1325                 1330                 1335             


Ser Arg  Leu Pro Lys Gln Ser  Ile Gly Gln Phe His  Glu Gly Asp 
    1340                 1345                 1350             


Ala Tyr  Val Val Lys Trp Lys  Phe Met Val Ser Thr  Ala Val Gly 
    1355                 1360                 1365             


Ser Arg  Gln Lys Gly Glu His  Ser Val Arg Ala Ala  Gly Lys Glu 
    1370                 1375                 1380             


Lys Cys  Val Tyr Phe Phe Trp  Gln Gly Arg His Ser  Thr Val Ser 
    1385                 1390                 1395             


Glu Lys  Gly Thr Ser Ala Leu  Met Thr Val Glu Leu  Asp Glu Glu 
    1400                 1405                 1410             


Arg Gly  Ala Gln Val Gln Val  Leu Gln Gly Lys Glu  Pro Pro Cys 
    1415                 1420                 1425             


Phe Leu  Gln Cys Phe Gln Gly  Gly Met Val Val His  Ser Gly Arg 
    1430                 1435                 1440             


Arg Glu  Glu Glu Glu Glu Asn  Val Gln Ser Glu Trp  Arg Leu Tyr 
    1445                 1450                 1455             


Cys Val  Arg Gly Glu Val Pro  Val Glu Gly Asn Leu  Leu Glu Val 
    1460                 1465                 1470             


Ala Cys  His Cys Ser Ser Leu  Arg Ser Arg Thr Ser  Met Val Val 
    1475                 1480                 1485             


Leu Asn  Val Asn Lys Ala Leu  Ile Tyr Leu Trp His  Gly Cys Lys 
    1490                 1495                 1500             


Ala Gln  Ala His Thr Lys Glu  Val Gly Arg Thr Ala  Ala Asn Lys 
    1505                 1510                 1515             


Ile Lys  Glu Gln Cys Pro Leu  Glu Ala Gly Leu His  Ser Ser Ser 
    1520                 1525                 1530             


Lys Val  Thr Ile His Glu Cys  Asp Glu Gly Ser Glu  Pro Leu Gly 
    1535                 1540                 1545             


Phe Trp  Asp Ala Leu Gly Arg  Arg Asp Arg Lys Ala  Tyr Asp Cys 
    1550                 1555                 1560             


Met Leu  Gln Asp Pro Gly Ser  Phe Asn Phe Ala Pro  Arg Leu Phe 
    1565                 1570                 1575             


Ile Leu  Ser Ser Ser Ser Gly  Asp Phe Ala Ala Thr  Glu Phe Val 
    1580                 1585                 1590             


Tyr Pro  Ala Arg Ala Pro Ser  Val Val Ser Ser Met  Pro Phe Leu 
    1595                 1600                 1605             


Gln Glu  Asp Leu Tyr Ser Ala  Pro Gln Pro Ala Leu  Phe Leu Val 
    1610                 1615                 1620             


Asp Asn  His His Glu Val Tyr  Leu Trp Gln Gly Trp  Trp Pro Ile 
    1625                 1630                 1635             


Glu Asn  Lys Ile Thr Gly Ser  Ala Arg Ile Arg Trp  Ala Ser Asp 
    1640                 1645                 1650             


Arg Lys  Ser Ala Met Glu Thr  Val Leu Gln Tyr Cys  Lys Gly Lys 
    1655                 1660                 1665             


Asn Leu  Lys Lys Pro Ala Pro  Lys Ser Tyr Leu Ile  His Ala Gly 
    1670                 1675                 1680             


Leu Glu  Pro Leu Thr Phe Thr  Asn Met Phe Pro Ser  Trp Glu His 
    1685                 1690                 1695             


Arg Glu  Asp Ile Ala Glu Ile  Thr Glu Met Asp Thr  Glu Val Ser 
    1700                 1705                 1710             


Asn Gln  Ile Thr Leu Val Glu  Asp Val Leu Ala Lys  Leu Cys Lys 
    1715                 1720                 1725             


Thr Ile  Tyr Pro Leu Ala Asp  Leu Leu Ala Arg Pro  Leu Pro Glu 
    1730                 1735                 1740             


Gly Val  Asp Pro Leu Lys Leu  Glu Ile Tyr Leu Thr  Asp Glu Asp 
    1745                 1750                 1755             


Phe Glu  Phe Ala Leu Asp Met  Thr Arg Asp Glu Tyr  Asn Ala Leu 
    1760                 1765                 1770             


Pro Ala  Trp Lys Gln Val Asn  Leu Lys Lys Ala Lys  Gly Leu Phe 
    1775                 1780                 1785             


<210>  147
<211>  6829
<212>  DNA
<213>  Homo sapiens

<400>  147
cttctctccc agggcggtgc gacccggagc tccagcgccc gagtctccac ttcgtttgct     60

gaaacttgct ttctaccagc taagaaccat gctgcgagtg attgtggaat ctgccagcaa    120

tatccctaaa acgaaatttg gcaagccgga tcctattgtt tctgtcattt ttaaggatga    180

gaaaaagaaa acaaagaaag ttgataatga attgaaccct gtctggaatg agattttgga    240

gtttgacttg aggggtatac cactggactt ttcatcttcc cttgggatta ttgtgaaaga    300

ttttgagaca attggacaaa ataaattaat tggcacggcg actgtagccc tgaaggacct    360

gactggtgac cagagcagat ccctgccgta caagctgatc tccctgctaa atgaaaaagg    420

gcaagatact ggggccacca ttgacttggt gatcggctat gatccgcctt ctgctccaca    480

tccaaatgac ctgagcgggc ccagcgtgcc aggcatggga ggagatgggg aagaagatga    540

aggtgatgaa gacaggttgg acaatgcagt caggggccct gggcccaagg ggccagttgg    600

gacggtgtcg gaagctcagc ttgctcggag gctcaccaaa gtaaagaaca gccggcggat    660

gctgtcaaat aagccacagg acttccagat ccgcgtccga gtgattgagg gccgacagtt    720

aagtggtaac aacataaggc ctgtggtcaa agttcacgtc tgtggccaga cacaccgaac    780

aagaatcaag agaggaaaca accctttttt tgatgagttg tttttctaca atgtcaacat    840

gaccccttct gaattgatgg atgagatcat cagcatccgg gtttataatt ctcactctct    900

gcgggcagat tgtctgatgg gggaatttaa gattgatgtt ggatttgttt atgatgaacc    960

tggccatgct gtcatgagaa agtggcttct tctcaatgac ccggaagata ccagttcagg   1020

ttctaaaggt tatatgaaag tcagcatgtt tgtcctggga accggagatg agcctcctcc   1080

tgagagacga gatcgtgata atgacagtga tgatgtggag agtaatttgt tactccctgc   1140

tggcattgcc ctccggtggg tgaccttctt gctgaaaatc taccgagctg aggacatccc   1200

ccagatggat gatgccttct cacagacagt aaaggaaata tttggaggca atgcagataa   1260

gaaaaatctc gtggatcctt ttgtagaagt ttcctttgct ggaaaaaagg tttgtacaaa   1320

cataattgag aaaaatgcaa acccagagtg gaatcaggtc gtcaatcttc agatcaagtt   1380

tccttcagtg tgtgaaaaaa taaaactaac aatatatgac tgggaccgtc ttactaaaaa   1440

tgatgtagtt ggaacaacat atctacacct ctctaaaatt gctgcctctg gtggggaagt   1500

ggaagatttc tcatcttcgg gaactggggc tgcatcatat acagtaaaca caggagaaac   1560

agaggtaggc tttgttccaa cgtttggacc ttgttacctg aatctttatg gaagccccag   1620

ggagtacacg ggattcccag acccctatga tgagctgaat actggaaagg gggaaggagt   1680

tgcctacaga ggcaggatct tggttgaatt agccactttt cttgagaaga caccaccaga   1740

taaaaagctt gagcccattt caaatgatga cctgctggtt gttgagaaat accagcgaag   1800

gcggaagtac agcctgtctg ccgtgtttca ttcagccacc atgttgcaag atgttggtga   1860

ggccattcag tttgaagtca gcattgggaa ctatggcaac aagtttgaca ccacctgtaa   1920

gcctttggca tcaacaactc agtacagccg tgctgtattt gatggcaact actattatta   1980

cttgccttgg gcccacacca agccagttgt taccctgact tcatactggg aggatattag   2040

tcatcgcctg gatgcggtga acactctcct agctatggca gaacggctgc aaacaaatat   2100

agaagctcta aaatcaggga tacaaggtaa aattcctgca aaccagctgg ctgaattgtg   2160

gctgaagctg atagatgaag ttatagaaga cacgagatac acgttgcctc tcacagaagg   2220

aaaagccaac gtcacagttc tcgatactca gatccgaaag ctgcggtcca ggtctctctc   2280

ccaaatacat gaggcggctg tgaggatgag gtcggaagcc acagatgtga agtccacact   2340

ggcagaaatt gaggactggc ttgataaatt aatgcagctg actgaagagc cacagaacag   2400

catgcctgac atcatcatct ggatgatccg gggagagaag agactggcct atgcacgaat   2460

tcccgcacat caggtcttgt actccaccag tggtgagaat gcatctggaa aatactgtgg   2520

gaaaacccaa accatctttc tgaagtatcc acaggagaaa aacaacgggc caaaggtgcc   2580

tgtggagttg cgagtgaaca tctggctagg cttaagtgct gtggagaaga agtttaacag   2640

cttcgcagaa ggaactttca ccgtctttgc tgaaatgtat gaaaatcaag ctctcatgtt   2700

tggaaaatgg ggtacttctg gattagtagg acgtcataag ttttctgatg tcacaggaaa   2760

aataaaactc aagagggaat tttttctgcc tccaaaaggc tgggaatggg aaggagagtg   2820

gatagttgat cctgaaagaa gcttgctgac tgaggcagat gcaggtcaca cggagttcac   2880

tgatgaagtc tatcagaacg agagccgcta ccccgggggc gactggaagc cggccgagga   2940

cacctacacg gatgcgaacg gcgataaagc agcatcaccc agcgagttga cttgtcctcc   3000

aggttgggaa tgggaagatg atgcatggtc ttatgacata aatcgagcgg tggatgagaa   3060

aggctgggaa tatggaatca ccattcctcc tgatcataag cccaaatcct gggttgcagc   3120

agagaaaatg taccacactc atagacggcg aaggctggtc cgaaaacgca agaaagattt   3180

aacacagact gcttcaagca ccgcaagggc catggaggaa ttgcaagacc aagagggctg   3240

ggaatatgct tctctaattg gctggaaatt tcactggaaa caacgtagtt cagatacctt   3300

ccgccgcaga cgctggagga gaaaaatggc tccttcagaa acacatggtg cagctgccat   3360

ctttaaactt gaaggtgccc ttggggcaga cactaccgaa gatggggatg agaagagcct   3420

ggagaaacag aagcacagtg ccaccactgt gttcggagca aacaccccca ttgtttcctg   3480

caattttgac agagtctaca tctaccatct gcgctgctat gtctatcaag ccagaaacct   3540

cttggcttta gataaggata gcttttcaga tccatatgct catatctgtt tcctccatcg   3600

gagcaaaacc actgagatca tccattcaac cctgaatccc acgtgggacc aaacaattat   3660

attcgatgaa gttgaaatct atggggaacc ccaaacagtt ctacagaatc cacccaaagt   3720

tatcatggaa ctttttgaca atgaccaagt gggcaaagat gaatttttag gacgaagcat   3780

tttctctcct gtggtgaaac tgaactcaga aatggacatc acacccaaac ttctctggca   3840

cccagtaatg aatggagaca aagcctgcgg ggatgttctt gtaactgcag agctgattct   3900

gaggggcaag gatggctcca accttcccat tcttccccct caaagggcgc caaatctata   3960

catggtcccc caggggatca ggcctgtggt ccagctcact gccattgaga ttctagcttg   4020

gggcttaaga aatatgaaaa acttccagat ggcttctatc acatccccca gtcttgttgt   4080

ggagtgtgga ggagaaaggg tggaatcggt ggtgatcaaa aaccttaaga agacacccaa   4140

ctttccaagt tctgttctct tcatgaaagt gttcttgccc aaggaggaat tgtacatgcc   4200

cccactggtg atcaaggtca tcgaccacag gcagtttggg cggaagcctg tcgtcggcca   4260

gtgcaccatc gagcgcctgg accgctttcg ctgtgaccct tatgcaggga aagaggacat   4320

cgtcccacag ctcaaagcct cccttctgtc tgccccacca tgccgggaca tcgttatcga   4380

aatggaagac accaaaccat tactggcttc taagctgaca gaaaaggagg aagaaatcgt   4440

ggactggtgg agtaaatttt atgcttcctc aggggaacat gaaaaatgcg gacagtatat   4500

tcagaaaggc tattccaagc tcaagatata taattgtgaa ctagaaaatg tagcagaatt   4560

tgagggcctg acagacttct cagatacgtt caagttgtac cgaggcaagt cggatgaaaa   4620

tgaagatcct tctgtggttg gagagtttaa gggctccttt cggatctacc ctctgccgga   4680

tgaccccagc gtgccagccc ctcccagaca gtttcgggaa ttacctgaca gcgtcccaca   4740

ggaatgcacg gttaggattt acattgttcg aggcttagag ctccagcccc aggacaacaa   4800

tggcctgtgt gacccttaca taaaaataac actgggcaaa aaagtcattg aagaccgaga   4860

tcactacatt cccaacactc tcaacccagt ctttggcagg atgtacgaac tgagctgcta   4920

cttacctcaa gaaaaagacc tgaaaatttc tgtctatgat tatgacacct ttacccggga   4980

tgaaaaagta ggagaaacaa ttattgatct ggaaaaccga ttcctttccc gctttgggtc   5040

ccactgcggc ataccagagg agtactgtgt ttctggagtc aatacctggc gagatcaact   5100

gagaccaaca cagctgcttc aaaatgtcgc cagattcaaa ggcttcccac aacccatcct   5160

ttccgaagat gggagtagaa tcagatatgg aggacgagac tacagcttgg atgaatttga   5220

agccaacaaa atcctgcacc agcacctcgg ggcccctgaa gagcggcttg ctcttcacat   5280

cctcaggact caggggctgg tccctgagca cgtggaaaca aggactttgc acagcacctt   5340

ccagcccaac atttcccagg gaaaacttca gatgtgggtg gatgttttcc ccaagagttt   5400

ggggccacca ggccctcctt tcaacatcac accccggaaa gccaagaaat actacctgcg   5460

tgtgatcatc tggaacacca aggacgttat cttggacgag aaaagcatca caggagagga   5520

aatgagtgac atctacgtca aaggctggat tcctggcaat gaagaaaaca aacagaaaac   5580

agatgtccat tacagatctt tggatggtga agggaatttt aactggcgat ttgttttccc   5640

gtttgactac cttccagccg aacaactctg tatcgttgcg aaaaaagagc atttctggag   5700

tattgaccaa acggaatttc gaatcccacc caggctgatc attcagatat gggacaatga   5760

caagttttct ctggatgact acttgggttt cctagaactt gacttgcgtc acacgatcat   5820

tcctgcaaaa tcaccagaga aatgcaggtt ggacatgatt ccggacctca aagccatgaa   5880

cccccttaaa gccaagacag cctccctctt tgagcagaag tccatgaaag gatggtggcc   5940

atgctacgca gagaaagatg gcgcccgcgt aatggctggg aaagtggaga tgacattgga   6000

aatcctcaac gagaaggagg ccgacgagag gccagccggg aaggggcggg acgaacccaa   6060

catgaacccc aagctggact taccaaatcg accagaaacc tccttcctct ggttcaccaa   6120

cccatgcaag accatgaagt tcatcgtgtg gcgccgcttt aagtgggtca tcatcggctt   6180

gctgttcctg cttatcctgc tgctcttcgt ggccgtgctc ctctactctt tgccgaacta   6240

tttgtcaatg aagattgtaa agccaaatgt gtaacaaagg caaaggcttc atttcaagag   6300

tcatccagca atgagagaat cctgcctctg tagaccaaca tccagtgtga ttttgtgtct   6360

gagaccacac cccagtagca ggttacgcca tgtcaccgag ccccattgat tcccagaggg   6420

tcttagtcct ggaaagtcag gccaacaagc aacgtttgca tcatgttatc tcttaagtat   6480

taaaagtttt attttctaaa gtttaaatca tgtttttcaa aatatttttc aaggtggctg   6540

gttccattta aaaatcatct ttttatatgt gtcttcggtt ctagacttca gcttttggaa   6600

attgctaaat agaattcaaa aatctctgca tcctgaggtg atatacttca tatttgtaat   6660

caactgaaag agctgtgcat tataaaatca gttagaatag ttagaacaat tcttatttat   6720

gcccacaacc attgctatat tttgtatgga tgtcataaaa gtctatttaa cctctgtaat   6780

gaaactaaat aaaaatgttt cacctttaaa aaaaaaaaaa aaaaaaaaa               6829


<210>  148
<211>  2061
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Leu Arg Val Ile Val Glu Ser Ala Ser Asn Ile Pro Lys Thr Lys 
1               5                   10                  15      


Phe Gly Lys Pro Asp Pro Ile Val Ser Val Ile Phe Lys Asp Glu Lys 
            20                  25                  30          


Lys Lys Thr Lys Lys Val Asp Asn Glu Leu Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Ile Leu Glu Phe Asp Leu Arg Gly Ile Pro Leu Asp Phe Ser Ser Ser 
    50                  55                  60                  


Leu Gly Ile Ile Val Lys Asp Phe Glu Thr Ile Gly Gln Asn Lys Leu 
65                  70                  75                  80  


Ile Gly Thr Ala Thr Val Ala Leu Lys Asp Leu Thr Gly Asp Gln Ser 
                85                  90                  95      


Arg Ser Leu Pro Tyr Lys Leu Ile Ser Leu Leu Asn Glu Lys Gly Gln 
            100                 105                 110         


Asp Thr Gly Ala Thr Ile Asp Leu Val Ile Gly Tyr Asp Pro Pro Ser 
        115                 120                 125             


Ala Pro His Pro Asn Asp Leu Ser Gly Pro Ser Val Pro Gly Met Gly 
    130                 135                 140                 


Gly Asp Gly Glu Glu Asp Glu Gly Asp Glu Asp Arg Leu Asp Asn Ala 
145                 150                 155                 160 


Val Arg Gly Pro Gly Pro Lys Gly Pro Val Gly Thr Val Ser Glu Ala 
                165                 170                 175     


Gln Leu Ala Arg Arg Leu Thr Lys Val Lys Asn Ser Arg Arg Met Leu 
            180                 185                 190         


Ser Asn Lys Pro Gln Asp Phe Gln Ile Arg Val Arg Val Ile Glu Gly 
        195                 200                 205             


Arg Gln Leu Ser Gly Asn Asn Ile Arg Pro Val Val Lys Val His Val 
    210                 215                 220                 


Cys Gly Gln Thr His Arg Thr Arg Ile Lys Arg Gly Asn Asn Pro Phe 
225                 230                 235                 240 


Phe Asp Glu Leu Phe Phe Tyr Asn Val Asn Met Thr Pro Ser Glu Leu 
                245                 250                 255     


Met Asp Glu Ile Ile Ser Ile Arg Val Tyr Asn Ser His Ser Leu Arg 
            260                 265                 270         


Ala Asp Cys Leu Met Gly Glu Phe Lys Ile Asp Val Gly Phe Val Tyr 
        275                 280                 285             


Asp Glu Pro Gly His Ala Val Met Arg Lys Trp Leu Leu Leu Asn Asp 
    290                 295                 300                 


Pro Glu Asp Thr Ser Ser Gly Ser Lys Gly Tyr Met Lys Val Ser Met 
305                 310                 315                 320 


Phe Val Leu Gly Thr Gly Asp Glu Pro Pro Pro Glu Arg Arg Asp Arg 
                325                 330                 335     


Asp Asn Asp Ser Asp Asp Val Glu Ser Asn Leu Leu Leu Pro Ala Gly 
            340                 345                 350         


Ile Ala Leu Arg Trp Val Thr Phe Leu Leu Lys Ile Tyr Arg Ala Glu 
        355                 360                 365             


Asp Ile Pro Gln Met Asp Asp Ala Phe Ser Gln Thr Val Lys Glu Ile 
    370                 375                 380                 


Phe Gly Gly Asn Ala Asp Lys Lys Asn Leu Val Asp Pro Phe Val Glu 
385                 390                 395                 400 


Val Ser Phe Ala Gly Lys Lys Val Cys Thr Asn Ile Ile Glu Lys Asn 
                405                 410                 415     


Ala Asn Pro Glu Trp Asn Gln Val Val Asn Leu Gln Ile Lys Phe Pro 
            420                 425                 430         


Ser Val Cys Glu Lys Ile Lys Leu Thr Ile Tyr Asp Trp Asp Arg Leu 
        435                 440                 445             


Thr Lys Asn Asp Val Val Gly Thr Thr Tyr Leu His Leu Ser Lys Ile 
    450                 455                 460                 


Ala Ala Ser Gly Gly Glu Val Glu Asp Phe Ser Ser Ser Gly Thr Gly 
465                 470                 475                 480 


Ala Ala Ser Tyr Thr Val Asn Thr Gly Glu Thr Glu Val Gly Phe Val 
                485                 490                 495     


Pro Thr Phe Gly Pro Cys Tyr Leu Asn Leu Tyr Gly Ser Pro Arg Glu 
            500                 505                 510         


Tyr Thr Gly Phe Pro Asp Pro Tyr Asp Glu Leu Asn Thr Gly Lys Gly 
        515                 520                 525             


Glu Gly Val Ala Tyr Arg Gly Arg Ile Leu Val Glu Leu Ala Thr Phe 
    530                 535                 540                 


Leu Glu Lys Thr Pro Pro Asp Lys Lys Leu Glu Pro Ile Ser Asn Asp 
545                 550                 555                 560 


Asp Leu Leu Val Val Glu Lys Tyr Gln Arg Arg Arg Lys Tyr Ser Leu 
                565                 570                 575     


Ser Ala Val Phe His Ser Ala Thr Met Leu Gln Asp Val Gly Glu Ala 
            580                 585                 590         


Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe Asp Thr 
        595                 600                 605             


Thr Cys Lys Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala Val Phe 
    610                 615                 620                 


Asp Gly Asn Tyr Tyr Tyr Tyr Leu Pro Trp Ala His Thr Lys Pro Val 
625                 630                 635                 640 


Val Thr Leu Thr Ser Tyr Trp Glu Asp Ile Ser His Arg Leu Asp Ala 
                645                 650                 655     


Val Asn Thr Leu Leu Ala Met Ala Glu Arg Leu Gln Thr Asn Ile Glu 
            660                 665                 670         


Ala Leu Lys Ser Gly Ile Gln Gly Lys Ile Pro Ala Asn Gln Leu Ala 
        675                 680                 685             


Glu Leu Trp Leu Lys Leu Ile Asp Glu Val Ile Glu Asp Thr Arg Tyr 
    690                 695                 700                 


Thr Leu Pro Leu Thr Glu Gly Lys Ala Asn Val Thr Val Leu Asp Thr 
705                 710                 715                 720 


Gln Ile Arg Lys Leu Arg Ser Arg Ser Leu Ser Gln Ile His Glu Ala 
                725                 730                 735     


Ala Val Arg Met Arg Ser Glu Ala Thr Asp Val Lys Ser Thr Leu Ala 
            740                 745                 750         


Glu Ile Glu Asp Trp Leu Asp Lys Leu Met Gln Leu Thr Glu Glu Pro 
        755                 760                 765             


Gln Asn Ser Met Pro Asp Ile Ile Ile Trp Met Ile Arg Gly Glu Lys 
    770                 775                 780                 


Arg Leu Ala Tyr Ala Arg Ile Pro Ala His Gln Val Leu Tyr Ser Thr 
785                 790                 795                 800 


Ser Gly Glu Asn Ala Ser Gly Lys Tyr Cys Gly Lys Thr Gln Thr Ile 
                805                 810                 815     


Phe Leu Lys Tyr Pro Gln Glu Lys Asn Asn Gly Pro Lys Val Pro Val 
            820                 825                 830         


Glu Leu Arg Val Asn Ile Trp Leu Gly Leu Ser Ala Val Glu Lys Lys 
        835                 840                 845             


Phe Asn Ser Phe Ala Glu Gly Thr Phe Thr Val Phe Ala Glu Met Tyr 
    850                 855                 860                 


Glu Asn Gln Ala Leu Met Phe Gly Lys Trp Gly Thr Ser Gly Leu Val 
865                 870                 875                 880 


Gly Arg His Lys Phe Ser Asp Val Thr Gly Lys Ile Lys Leu Lys Arg 
                885                 890                 895     


Glu Phe Phe Leu Pro Pro Lys Gly Trp Glu Trp Glu Gly Glu Trp Ile 
            900                 905                 910         


Val Asp Pro Glu Arg Ser Leu Leu Thr Glu Ala Asp Ala Gly His Thr 
        915                 920                 925             


Glu Phe Thr Asp Glu Val Tyr Gln Asn Glu Ser Arg Tyr Pro Gly Gly 
    930                 935                 940                 


Asp Trp Lys Pro Ala Glu Asp Thr Tyr Thr Asp Ala Asn Gly Asp Lys 
945                 950                 955                 960 


Ala Ala Ser Pro Ser Glu Leu Thr Cys Pro Pro Gly Trp Glu Trp Glu 
                965                 970                 975     


Asp Asp Ala Trp Ser Tyr Asp Ile Asn Arg Ala Val Asp Glu Lys Gly 
            980                 985                 990         


Trp Glu Tyr Gly Ile Thr Ile Pro  Pro Asp His Lys Pro  Lys Ser Trp 
        995                 1000                 1005             


Val Ala  Ala Glu Lys Met Tyr  His Thr His Arg Arg  Arg Arg Leu 
    1010                 1015                 1020             


Val Arg  Lys Arg Lys Lys Asp  Leu Thr Gln Thr Ala  Ser Ser Thr 
    1025                 1030                 1035             


Ala Arg  Ala Met Glu Glu Leu  Gln Asp Gln Glu Gly  Trp Glu Tyr 
    1040                 1045                 1050             


Ala Ser  Leu Ile Gly Trp Lys  Phe His Trp Lys Gln  Arg Ser Ser 
    1055                 1060                 1065             


Asp Thr  Phe Arg Arg Arg Arg  Trp Arg Arg Lys Met  Ala Pro Ser 
    1070                 1075                 1080             


Glu Thr  His Gly Ala Ala Ala  Ile Phe Lys Leu Glu  Gly Ala Leu 
    1085                 1090                 1095             


Gly Ala  Asp Thr Thr Glu Asp  Gly Asp Glu Lys Ser  Leu Glu Lys 
    1100                 1105                 1110             


Gln Lys  His Ser Ala Thr Thr  Val Phe Gly Ala Asn  Thr Pro Ile 
    1115                 1120                 1125             


Val Ser  Cys Asn Phe Asp Arg  Val Tyr Ile Tyr His  Leu Arg Cys 
    1130                 1135                 1140             


Tyr Val  Tyr Gln Ala Arg Asn  Leu Leu Ala Leu Asp  Lys Asp Ser 
    1145                 1150                 1155             


Phe Ser  Asp Pro Tyr Ala His  Ile Cys Phe Leu His  Arg Ser Lys 
    1160                 1165                 1170             


Thr Thr  Glu Ile Ile His Ser  Thr Leu Asn Pro Thr  Trp Asp Gln 
    1175                 1180                 1185             


Thr Ile  Ile Phe Asp Glu Val  Glu Ile Tyr Gly Glu  Pro Gln Thr 
    1190                 1195                 1200             


Val Leu  Gln Asn Pro Pro Lys  Val Ile Met Glu Leu  Phe Asp Asn 
    1205                 1210                 1215             


Asp Gln  Val Gly Lys Asp Glu  Phe Leu Gly Arg Ser  Ile Phe Ser 
    1220                 1225                 1230             


Pro Val  Val Lys Leu Asn Ser  Glu Met Asp Ile Thr  Pro Lys Leu 
    1235                 1240                 1245             


Leu Trp  His Pro Val Met Asn  Gly Asp Lys Ala Cys  Gly Asp Val 
    1250                 1255                 1260             


Leu Val  Thr Ala Glu Leu Ile  Leu Arg Gly Lys Asp  Gly Ser Asn 
    1265                 1270                 1275             


Leu Pro  Ile Leu Pro Pro Gln  Arg Ala Pro Asn Leu  Tyr Met Val 
    1280                 1285                 1290             


Pro Gln  Gly Ile Arg Pro Val  Val Gln Leu Thr Ala  Ile Glu Ile 
    1295                 1300                 1305             


Leu Ala  Trp Gly Leu Arg Asn  Met Lys Asn Phe Gln  Met Ala Ser 
    1310                 1315                 1320             


Ile Thr  Ser Pro Ser Leu Val  Val Glu Cys Gly Gly  Glu Arg Val 
    1325                 1330                 1335             


Glu Ser  Val Val Ile Lys Asn  Leu Lys Lys Thr Pro  Asn Phe Pro 
    1340                 1345                 1350             


Ser Ser  Val Leu Phe Met Lys  Val Phe Leu Pro Lys  Glu Glu Leu 
    1355                 1360                 1365             


Tyr Met  Pro Pro Leu Val Ile  Lys Val Ile Asp His  Arg Gln Phe 
    1370                 1375                 1380             


Gly Arg  Lys Pro Val Val Gly  Gln Cys Thr Ile Glu  Arg Leu Asp 
    1385                 1390                 1395             


Arg Phe  Arg Cys Asp Pro Tyr  Ala Gly Lys Glu Asp  Ile Val Pro 
    1400                 1405                 1410             


Gln Leu  Lys Ala Ser Leu Leu  Ser Ala Pro Pro Cys  Arg Asp Ile 
    1415                 1420                 1425             


Val Ile  Glu Met Glu Asp Thr  Lys Pro Leu Leu Ala  Ser Lys Leu 
    1430                 1435                 1440             


Thr Glu  Lys Glu Glu Glu Ile  Val Asp Trp Trp Ser  Lys Phe Tyr 
    1445                 1450                 1455             


Ala Ser  Ser Gly Glu His Glu  Lys Cys Gly Gln Tyr  Ile Gln Lys 
    1460                 1465                 1470             


Gly Tyr  Ser Lys Leu Lys Ile  Tyr Asn Cys Glu Leu  Glu Asn Val 
    1475                 1480                 1485             


Ala Glu  Phe Glu Gly Leu Thr  Asp Phe Ser Asp Thr  Phe Lys Leu 
    1490                 1495                 1500             


Tyr Arg  Gly Lys Ser Asp Glu  Asn Glu Asp Pro Ser  Val Val Gly 
    1505                 1510                 1515             


Glu Phe  Lys Gly Ser Phe Arg  Ile Tyr Pro Leu Pro  Asp Asp Pro 
    1520                 1525                 1530             


Ser Val  Pro Ala Pro Pro Arg  Gln Phe Arg Glu Leu  Pro Asp Ser 
    1535                 1540                 1545             


Val Pro  Gln Glu Cys Thr Val  Arg Ile Tyr Ile Val  Arg Gly Leu 
    1550                 1555                 1560             


Glu Leu  Gln Pro Gln Asp Asn  Asn Gly Leu Cys Asp  Pro Tyr Ile 
    1565                 1570                 1575             


Lys Ile  Thr Leu Gly Lys Lys  Val Ile Glu Asp Arg  Asp His Tyr 
    1580                 1585                 1590             


Ile Pro  Asn Thr Leu Asn Pro  Val Phe Gly Arg Met  Tyr Glu Leu 
    1595                 1600                 1605             


Ser Cys  Tyr Leu Pro Gln Glu  Lys Asp Leu Lys Ile  Ser Val Tyr 
    1610                 1615                 1620             


Asp Tyr  Asp Thr Phe Thr Arg  Asp Glu Lys Val Gly  Glu Thr Ile 
    1625                 1630                 1635             


Ile Asp  Leu Glu Asn Arg Phe  Leu Ser Arg Phe Gly  Ser His Cys 
    1640                 1645                 1650             


Gly Ile  Pro Glu Glu Tyr Cys  Val Ser Gly Val Asn  Thr Trp Arg 
    1655                 1660                 1665             


Asp Gln  Leu Arg Pro Thr Gln  Leu Leu Gln Asn Val  Ala Arg Phe 
    1670                 1675                 1680             


Lys Gly  Phe Pro Gln Pro Ile  Leu Ser Glu Asp Gly  Ser Arg Ile 
    1685                 1690                 1695             


Arg Tyr  Gly Gly Arg Asp Tyr  Ser Leu Asp Glu Phe  Glu Ala Asn 
    1700                 1705                 1710             


Lys Ile  Leu His Gln His Leu  Gly Ala Pro Glu Glu  Arg Leu Ala 
    1715                 1720                 1725             


Leu His  Ile Leu Arg Thr Gln  Gly Leu Val Pro Glu  His Val Glu 
    1730                 1735                 1740             


Thr Arg  Thr Leu His Ser Thr  Phe Gln Pro Asn Ile  Ser Gln Gly 
    1745                 1750                 1755             


Lys Leu  Gln Met Trp Val Asp  Val Phe Pro Lys Ser  Leu Gly Pro 
    1760                 1765                 1770             


Pro Gly  Pro Pro Phe Asn Ile  Thr Pro Arg Lys Ala  Lys Lys Tyr 
    1775                 1780                 1785             


Tyr Leu  Arg Val Ile Ile Trp  Asn Thr Lys Asp Val  Ile Leu Asp 
    1790                 1795                 1800             


Glu Lys  Ser Ile Thr Gly Glu  Glu Met Ser Asp Ile  Tyr Val Lys 
    1805                 1810                 1815             


Gly Trp  Ile Pro Gly Asn Glu  Glu Asn Lys Gln Lys  Thr Asp Val 
    1820                 1825                 1830             


His Tyr  Arg Ser Leu Asp Gly  Glu Gly Asn Phe Asn  Trp Arg Phe 
    1835                 1840                 1845             


Val Phe  Pro Phe Asp Tyr Leu  Pro Ala Glu Gln Leu  Cys Ile Val 
    1850                 1855                 1860             


Ala Lys  Lys Glu His Phe Trp  Ser Ile Asp Gln Thr  Glu Phe Arg 
    1865                 1870                 1875             


Ile Pro  Pro Arg Leu Ile Ile  Gln Ile Trp Asp Asn  Asp Lys Phe 
    1880                 1885                 1890             


Ser Leu  Asp Asp Tyr Leu Gly  Phe Leu Glu Leu Asp  Leu Arg His 
    1895                 1900                 1905             


Thr Ile  Ile Pro Ala Lys Ser  Pro Glu Lys Cys Arg  Leu Asp Met 
    1910                 1915                 1920             


Ile Pro  Asp Leu Lys Ala Met  Asn Pro Leu Lys Ala  Lys Thr Ala 
    1925                 1930                 1935             


Ser Leu  Phe Glu Gln Lys Ser  Met Lys Gly Trp Trp  Pro Cys Tyr 
    1940                 1945                 1950             


Ala Glu  Lys Asp Gly Ala Arg  Val Met Ala Gly Lys  Val Glu Met 
    1955                 1960                 1965             


Thr Leu  Glu Ile Leu Asn Glu  Lys Glu Ala Asp Glu  Arg Pro Ala 
    1970                 1975                 1980             


Gly Lys  Gly Arg Asp Glu Pro  Asn Met Asn Pro Lys  Leu Asp Leu 
    1985                 1990                 1995             


Pro Asn  Arg Pro Glu Thr Ser  Phe Leu Trp Phe Thr  Asn Pro Cys 
    2000                 2005                 2010             


Lys Thr  Met Lys Phe Ile Val  Trp Arg Arg Phe Lys  Trp Val Ile 
    2015                 2020                 2025             


Ile Gly  Leu Leu Phe Leu Leu  Ile Leu Leu Leu Phe  Val Ala Val 
    2030                 2035                 2040             


Leu Leu  Tyr Ser Leu Pro Asn  Tyr Leu Ser Met Lys  Ile Val Lys 
    2045                 2050                 2055             


Pro Asn  Val 
    2060     


<210>  149
<211>  1551
<212>  DNA
<213>  Homo sapiens

<400>  149
cctgagctca ggagtttgag accagcctgt ctctactaac aatataaaaa ttagctggga     60

gtcacggtgg gcgcctgtaa tcccagctac tcgggaggct gaggcaggag aattgcttga    120

acccaggaga cagaggttgt agtgagctga gatcgcacca ctgcactcta gccttggcaa    180

cagtgcaaga ctgtctcaaa aacagcaaca gagagcagga cgtgagactt ctacctgctc    240

actcagaatc atttctgcac caaccatggc cacgtttgtg gagctcagta ccaaagccaa    300

gatgcccatt gtgggcctgg gcacttggaa gtctcctctt ggcaaagtga aagaagcagt    360

gaaggtggcc attgatgcag gatatcggca cattgactgt gcctatgtct atcagaatga    420

acatgaagtg ggggaagcca tccaagagaa gatccaagag aaggctgtga agcgggagga    480

cctgttcatc gtcagcaagt tgtggcccac tttctttgag agaccccttg tgaggaaagc    540

ctttgagaag accctcaagg acctgaagct gagctatctg gacgtctatc ttattcactg    600

gccacaggga ttcaagtctg gggatgacct tttccccaaa gatgataaag gtaatgccat    660

cggtggaaaa gcaacgttct tggatgcctg ggaggccatg gaggagctgg tggatgaggg    720

gctggtgaaa gcccttgggg tctccaattt cagccacttc cagatcgaga agctcttgaa    780

caaacctgga ctgaaatata aaccagtgac taaccaggtt gagtgtcacc catacctcac    840

acaggagaaa ctgatccagt actgccactc caagggcatc accgttacgg cctacagccc    900

cctgggctct ccggatagac cttgggccaa gccagaagac ccttccctgc tggaggatcc    960

caagattaag gagattgctg caaagcacaa aaaaaccgca gcccaggttc tgatccgttt   1020

ccatatccag aggaatgtga ttgtcatccc caagtctgtg acaccagcac gcattgttga   1080

gaacattcag gtctttgact ttaaattgag tgatgaggag atggcaacca tactcagctt   1140

caacagaaac tggagggcct gtaacgtgtt gcaatcctct catttggaag actatccctt   1200

cgatgcagaa tattgaggtt gaatctcctg gtgagattat acaggagatt ctctttcttc   1260

gctgaagtgt gactacctcc actcatgtcc cattttagcc aagcttattt aagatcacag   1320

tgaacttagt cctgttatag acgagaatcg aggtgctgtt ttagacattt atttctgtat   1380

gttcaactag gatcagaata tcacagaaaa gcatggcttg aataaggaaa tgacaatttt   1440

ttccacttat ctgatcagaa caaatgttta ttaagcatca gaaactctgc caacactgag   1500

gatgtaaaga tcaataaaaa aaataataat cataaaaaaa aaaaaaaaaa a            1551


<210>  150
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Ala Thr Phe Val Glu Leu Ser Thr Lys Ala Lys Met Pro Ile Val 
1               5                   10                  15      


Gly Leu Gly Thr Trp Lys Ser Pro Leu Gly Lys Val Lys Glu Ala Val 
            20                  25                  30          


Lys Val Ala Ile Asp Ala Gly Tyr Arg His Ile Asp Cys Ala Tyr Val 
        35                  40                  45              


Tyr Gln Asn Glu His Glu Val Gly Glu Ala Ile Gln Glu Lys Ile Gln 
    50                  55                  60                  


Glu Lys Ala Val Lys Arg Glu Asp Leu Phe Ile Val Ser Lys Leu Trp 
65                  70                  75                  80  


Pro Thr Phe Phe Glu Arg Pro Leu Val Arg Lys Ala Phe Glu Lys Thr 
                85                  90                  95      


Leu Lys Asp Leu Lys Leu Ser Tyr Leu Asp Val Tyr Leu Ile His Trp 
            100                 105                 110         


Pro Gln Gly Phe Lys Ser Gly Asp Asp Leu Phe Pro Lys Asp Asp Lys 
        115                 120                 125             


Gly Asn Ala Ile Gly Gly Lys Ala Thr Phe Leu Asp Ala Trp Glu Ala 
    130                 135                 140                 


Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Leu Gly Val Ser 
145                 150                 155                 160 


Asn Phe Ser His Phe Gln Ile Glu Lys Leu Leu Asn Lys Pro Gly Leu 
                165                 170                 175     


Lys Tyr Lys Pro Val Thr Asn Gln Val Glu Cys His Pro Tyr Leu Thr 
            180                 185                 190         


Gln Glu Lys Leu Ile Gln Tyr Cys His Ser Lys Gly Ile Thr Val Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 
    210                 215                 220                 


Asp Pro Ser Leu Leu Glu Asp Pro Lys Ile Lys Glu Ile Ala Ala Lys 
225                 230                 235                 240 


His Lys Lys Thr Ala Ala Gln Val Leu Ile Arg Phe His Ile Gln Arg 
                245                 250                 255     


Asn Val Ile Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Val Glu 
            260                 265                 270         


Asn Ile Gln Val Phe Asp Phe Lys Leu Ser Asp Glu Glu Met Ala Thr 
        275                 280                 285             


Ile Leu Ser Phe Asn Arg Asn Trp Arg Ala Cys Asn Val Leu Gln Ser 
    290                 295                 300                 


Ser His Leu Glu Asp Tyr Pro Phe Asp Ala Glu Tyr 
305                 310                 315     


<210>  151
<211>  1412
<212>  DNA
<213>  Homo sapiens

<400>  151
ggctgcgctt ccctggtcag gcacggcacg tctggccggc cgccaggatg caggccccgc     60

acaaggagca cctgtacaag ttgctggtga ttggcgacct gggcgtgggg aagaccagta    120

tcatcaagcg ctacgtgcac cagaacttct cctcgcacta ccgggccaca atcggcgtgg    180

acttcgcgct caaggtgctc cactgggacc cggagactgt ggtgcgcctg cagctctggg    240

atatcgcagg tcaagaaaga tttggaaaca tgacgagggt ctattaccga gaagctatgg    300

gtgcatttat tgtcttcgat gtcaccaggc cagccacatt tgaagcagtg gcaaagtgga    360

aaaatgattt ggactccaag ttaagtctcc ctaatggcaa accggtttca gtggttttgt    420

tggccaacaa atgtgaccag gggaaggatg tgctcatgaa caatggcctc aagatggacc    480

agttctgcaa ggagcacggt ttcgtaggat ggtttgaaac atcagcaaag gaaaatataa    540

acattgatga agcctccaga tgcctggtga aacacatact tgcaaatgag tgtgacctaa    600

tggagtctat tgagccggac gtcgtgaagc cccatctcac atcaaccaag gttgccagct    660

gctctggctg tgccaaatcc tagtaggcac ctttgctggt gtctggtagg aatgacctca    720

ttgttccaca aattgtgcct ctatttttac cattttgggt aaacgtcagg atagatatac    780

cacatgtggc aagccaaaga tctatgcctc tgttttttca atgagagaga aatagcaaat    840

gttctttcta tgctttcctc accatcatca cagtgtttac aaacttttga aaatatttag    900

tctgttacaa acttctgtca tgtagctgac caaaatcctg cagggccaca gtcggcactg    960

ttatttgctt cttttaatca gcaaaggcct caagtcttaa aataaaaggg gagaagaaca   1020

aactagctgt caagtcaagg actggctttc accttgccct ggtgtctttt tccagatttc   1080

aatatattct ctgatggcct gacaggccta ttaagtagat gtgatatttt cttccaagat   1140

gacctccatt ctcggcagac ctaagagttg cctctgagtt agctctttgg aatcgtgaac   1200

acaggtgtgc tatattgtcc ttgtcctaac tgtcacttgc catggcctga atgttggctt   1260

aactgaatat tgtatgaaaa gacatgcctc catatgtgcc tttctgttag ctctctttga   1320

ctcaagctgt ggggctcctc tatacatgct atacatgtaa tatatattat atatattttt   1380

gcaagtgaac aataaaacat taaaagataa aa                                 1412


<210>  152
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Gln Ala Pro His Lys Glu His Leu Tyr Lys Leu Leu Val Ile Gly 
1               5                   10                  15      


Asp Leu Gly Val Gly Lys Thr Ser Ile Ile Lys Arg Tyr Val His Gln 
            20                  25                  30          


Asn Phe Ser Ser His Tyr Arg Ala Thr Ile Gly Val Asp Phe Ala Leu 
        35                  40                  45              


Lys Val Leu His Trp Asp Pro Glu Thr Val Val Arg Leu Gln Leu Trp 
    50                  55                  60                  


Asp Ile Ala Gly Gln Glu Arg Phe Gly Asn Met Thr Arg Val Tyr Tyr 
65                  70                  75                  80  


Arg Glu Ala Met Gly Ala Phe Ile Val Phe Asp Val Thr Arg Pro Ala 
                85                  90                  95      


Thr Phe Glu Ala Val Ala Lys Trp Lys Asn Asp Leu Asp Ser Lys Leu 
            100                 105                 110         


Ser Leu Pro Asn Gly Lys Pro Val Ser Val Val Leu Leu Ala Asn Lys 
        115                 120                 125             


Cys Asp Gln Gly Lys Asp Val Leu Met Asn Asn Gly Leu Lys Met Asp 
    130                 135                 140                 


Gln Phe Cys Lys Glu His Gly Phe Val Gly Trp Phe Glu Thr Ser Ala 
145                 150                 155                 160 


Lys Glu Asn Ile Asn Ile Asp Glu Ala Ser Arg Cys Leu Val Lys His 
                165                 170                 175     


Ile Leu Ala Asn Glu Cys Asp Leu Met Glu Ser Ile Glu Pro Asp Val 
            180                 185                 190         


Val Lys Pro His Leu Thr Ser Thr Lys Val Ala Ser Cys Ser Gly Cys 
        195                 200                 205             


Ala Lys Ser 
    210     


<210>  153
<211>  2060
<212>  DNA
<213>  Homo sapiens

<400>  153
tgttcccagc actcaagcct tgccaccgcc gagccgggct tcctgggtgt ttcaggcaag     60

gaagtctagg tccctggggg gtgaccccca aggaaaaggc agcctccctg cgcacccggt    120

tgcccggagc cctctccagg gccggctggg ctgggggttg ccctggccag caggggcccg    180

ggggcgatgc cacccggtgc cgactgaggc caccgcacca tggcccgctc gctgacctgg    240

cgctgctgcc cctggtgcct gacggaggat gagaaggccg ccgcccgggt ggaccaggag    300

atcaacagga tcctcttgga gcagaagaag caggaccgcg gggagctgaa gctgctgctt    360

ttgggcccag gcgagagcgg gaagagcacc ttcatcaagc agatgcggat catccacggc    420

gccggctact cggaggagga gcgcaagggc ttccggcccc tggtctacca gaacatcttc    480

gtgtccatgc gggccatgat cgaggccatg gagcggctgc agattccatt cagcaggccc    540

gagagcaagc accacgctag cctggtcatg agccaggacc cctataaagt gaccacgttt    600

gagaagcgct acgctgcggc catgcagtgg ctgtggaggg atgccggcat ccgggcctgc    660

tatgagcgtc ggcgggaatt ccacctgctc gattcagccg tgtactacct gtcccacctg    720

gagcgcatca ccgaggaggg ctacgtcccc acagctcagg acgtgctccg cagccgcatg    780

cccaccactg gcatcaacga gtactgcttc tccgtgcaga aaaccaacct gcggatcgtg    840

gacgtcgggg gccagaagtc agagcgtaag aaatggatcc attgtttcga gaacgtgatc    900

gccctcatct acctggcctc actgagtgaa tacgaccagt gcctggagga gaacaaccag    960

gagaaccgca tgaaggagag cctcgcattg tttgggacta tcctggaact accctggttc   1020

aaaagcacat ccgtcatcct ctttctcaac aaaaccgaca tcctggagga gaaaatcccc   1080

acctcccacc tggctaccta tttccccagt ttccagggcc ctaagcagga tgctgaggca   1140

gccaagaggt tcatcctgga catgtacacg aggatgtaca ccgggtgcgt ggacggcccc   1200

gagggcagca agaagggcgc acgatcccga cgccttttca gccactacac atgtgccaca   1260

gacacacaga acatccgcaa ggtcttcaag gacgtgcggg actcggtgct cgcccgctac   1320

ctggacgaga tcaacctgct gtgacccagg ccccacctgg ggcaggcggc accggcgggc   1380

gggtgggagg tgggagtggc tgcagggacc ctagtgtcct ggtctatctc tccagcctcg   1440

gcccacacgc aagggagtcg ggggacggcc cgctgctggc cgctctcttc tctgcctctc   1500

accaggacag ccgcccccca gggtactcct gcccttgctt gactcagttt ccctcctttg   1560

aaagggaagg agcaaaacgg ccatttggga tgccagggtg gatgaaaagg tgaagaaatc   1620

aggggattga gacttgggtg ggtgggcatc tctcaggagc cccatctccg ggcgtgtcac   1680

ctcctgggca gggttctggg accctctgtg ggtgacgcac accctgggat ggggctagta   1740

gagccttcag gcgccttcgg gcgtggactc tggcgcactc tagtggacag gagaaggaac   1800

gccttccagg aacctgtgga ctaggggtgc agggacttcc ctttgcaagg ggtaacagac   1860

cgctggaaaa cactgtcact ttcagagctc ggtggctcac agcgtgtcct gccccggttt   1920

gcggacgaga gaaatcgcgg cccacaagca tcccccatcc cttgcaggct gggggctggg   1980

catgctgcat cttaaccttt tgtatttatt ccctcacctt ctgcagggct ccgtgcgggc   2040

tgaaattaaa gatttcttag                                               2060


<210>  154
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Ala Arg Ser Leu Thr Trp Arg Cys Cys Pro Trp Cys Leu Thr Glu 
1               5                   10                  15      


Asp Glu Lys Ala Ala Ala Arg Val Asp Gln Glu Ile Asn Arg Ile Leu 
            20                  25                  30          


Leu Glu Gln Lys Lys Gln Asp Arg Gly Glu Leu Lys Leu Leu Leu Leu 
        35                  40                  45              


Gly Pro Gly Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile 
    50                  55                  60                  


Ile His Gly Ala Gly Tyr Ser Glu Glu Glu Arg Lys Gly Phe Arg Pro 
65                  70                  75                  80  


Leu Val Tyr Gln Asn Ile Phe Val Ser Met Arg Ala Met Ile Glu Ala 
                85                  90                  95      


Met Glu Arg Leu Gln Ile Pro Phe Ser Arg Pro Glu Ser Lys His His 
            100                 105                 110         


Ala Ser Leu Val Met Ser Gln Asp Pro Tyr Lys Val Thr Thr Phe Glu 
        115                 120                 125             


Lys Arg Tyr Ala Ala Ala Met Gln Trp Leu Trp Arg Asp Ala Gly Ile 
    130                 135                 140                 


Arg Ala Cys Tyr Glu Arg Arg Arg Glu Phe His Leu Leu Asp Ser Ala 
145                 150                 155                 160 


Val Tyr Tyr Leu Ser His Leu Glu Arg Ile Thr Glu Glu Gly Tyr Val 
                165                 170                 175     


Pro Thr Ala Gln Asp Val Leu Arg Ser Arg Met Pro Thr Thr Gly Ile 
            180                 185                 190         


Asn Glu Tyr Cys Phe Ser Val Gln Lys Thr Asn Leu Arg Ile Val Asp 
        195                 200                 205             


Val Gly Gly Gln Lys Ser Glu Arg Lys Lys Trp Ile His Cys Phe Glu 
    210                 215                 220                 


Asn Val Ile Ala Leu Ile Tyr Leu Ala Ser Leu Ser Glu Tyr Asp Gln 
225                 230                 235                 240 


Cys Leu Glu Glu Asn Asn Gln Glu Asn Arg Met Lys Glu Ser Leu Ala 
                245                 250                 255     


Leu Phe Gly Thr Ile Leu Glu Leu Pro Trp Phe Lys Ser Thr Ser Val 
            260                 265                 270         


Ile Leu Phe Leu Asn Lys Thr Asp Ile Leu Glu Glu Lys Ile Pro Thr 
        275                 280                 285             


Ser His Leu Ala Thr Tyr Phe Pro Ser Phe Gln Gly Pro Lys Gln Asp 
    290                 295                 300                 


Ala Glu Ala Ala Lys Arg Phe Ile Leu Asp Met Tyr Thr Arg Met Tyr 
305                 310                 315                 320 


Thr Gly Cys Val Asp Gly Pro Glu Gly Ser Lys Lys Gly Ala Arg Ser 
                325                 330                 335     


Arg Arg Leu Phe Ser His Tyr Thr Cys Ala Thr Asp Thr Gln Asn Ile 
            340                 345                 350         


Arg Lys Val Phe Lys Asp Val Arg Asp Ser Val Leu Ala Arg Tyr Leu 
        355                 360                 365             


Asp Glu Ile Asn Leu Leu 
    370                 


<210>  155
<211>  4714
<212>  DNA
<213>  Homo sapiens

<400>  155
ggagagggag aaggctctcg ggcggagaga ggtcctgccc agctgttggc gaggagtttc     60

ctgtttcccc cgcagcgctg agttgaagtt gagtgagtca ctcgcgcgca cggagcgacg    120

acacccccgc gcgtgcaccc gctcgggaca ggagccggac tcctgtgcag cttccctcgg    180

ccgccggggg cctccccgcg cctcgccggc ctccaggccc cctcctggct ggcgagcggg    240

cgccacatct ggcccgcaca tctgcgctgc cggcccggcg cggggtccgg agagggcgcg    300

gcgcggaggc gcagccaggg gtccgggaag gcgccgtccg ctgcgctggg ggctcggtct    360

atgacgagca gcggggtctg ccatgggtcg ggggctgctc aggggcctgt ggccgctgca    420

catcgtcctg tggacgcgta tcgccagcac gatcccaccg cacgttcaga agtcggatgt    480

ggaaatggag gcccagaaag atgaaatcat ctgccccagc tgtaatagga ctgcccatcc    540

actgagacat attaataacg acatgatagt cactgacaac aacggtgcag tcaagtttcc    600

acaactgtgt aaattttgtg atgtgagatt ttccacctgt gacaaccaga aatcctgcat    660

gagcaactgc agcatcacct ccatctgtga gaagccacag gaagtctgtg tggctgtatg    720

gagaaagaat gacgagaaca taacactaga gacagtttgc catgacccca agctccccta    780

ccatgacttt attctggaag atgctgcttc tccaaagtgc attatgaagg aaaaaaaaaa    840

gcctggtgag actttcttca tgtgttcctg tagctctgat gagtgcaatg acaacatcat    900

cttctcagaa gaatataaca ccagcaatcc tgacttgttg ctagtcatat ttcaagtgac    960

aggcatcagc ctcctgccac cactgggagt tgccatatct gtcatcatca tcttctactg   1020

ctaccgcgtt aaccggcagc agaagctgag ttcaacctgg gaaaccggca agacgcggaa   1080

gctcatggag ttcagcgagc actgtgccat catcctggaa gatgaccgct ctgacatcag   1140

ctccacgtgt gccaacaaca tcaaccacaa cacagagctg ctgcccattg agctggacac   1200

cctggtgggg aaaggtcgct ttgctgaggt ctataaggcc aagctgaagc agaacacttc   1260

agagcagttt gagacagtgg cagtcaagat ctttccctat gaggagtatg cctcttggaa   1320

gacagagaag gacatcttct cagacatcaa tctgaagcat gagaacatac tccagttcct   1380

gacggctgag gagcggaaga cggagttggg gaaacaatac tggctgatca ccgccttcca   1440

cgccaagggc aacctacagg agtacctgac gcggcatgtc atcagctggg aggacctgcg   1500

caagctgggc agctccctcg cccgggggat tgctcacctc cacagtgatc acactccatg   1560

tgggaggccc aagatgccca tcgtgcacag ggacctcaag agctccaata tcctcgtgaa   1620

gaacgaccta acctgctgcc tgtgtgactt tgggctttcc ctgcgtctgg accctactct   1680

gtctgtggat gacctggcta acagtgggca ggtgggaact gcaagataca tggctccaga   1740

agtcctagaa tccaggatga atttggagaa tgttgagtcc ttcaagcaga ccgatgtcta   1800

ctccatggct ctggtgctct gggaaatgac atctcgctgt aatgcagtgg gagaagtaaa   1860

agattatgag cctccatttg gttccaaggt gcgggagcac ccctgtgtcg aaagcatgaa   1920

ggacaacgtg ttgagagatc gagggcgacc agaaattccc agcttctggc tcaaccacca   1980

gggcatccag atggtgtgtg agacgttgac tgagtgctgg gaccacgacc cagaggcccg   2040

tctcacagcc cagtgtgtgg cagaacgctt cagtgagctg gagcatctgg acaggctctc   2100

ggggaggagc tgctcggagg agaagattcc tgaagacggc tccctaaaca ctaccaaata   2160

gctcttctgg ggcaggctgg gccatgtcca aagaggctgc ccctctcacc aaagaacaga   2220

ggcagcagga agctgcccct gaactgatgc ttcctggaaa accaaggggg tcactcccct   2280

ccctgtaagc tgtggggata agcagaaaca acagcagcag ggagtgggtg acatagagca   2340

ttctatgcct ttgacattgt cataggataa gctgtgttag cacttcctca ggaaatgaga   2400

ttgattttta caatagccaa taacatttgc actttattaa tgcctgtata taaatatgaa   2460

tagctatgtt ttatatatat atatatatat ctatatatgt ctatagctct atatatatag   2520

ccataccttg aaaagagaca aggaaaaaca tcaaatattc ccaggaaatt ggttttattg   2580

gagaactcca gaaccaagca gagaaggaag ggacccatga cagcattagc atttgacaat   2640

cacacatgca gtggttctct gactgtaaaa cagtgaactt tgcatgagga aagaggctcc   2700

atgtctcaca gccagctatg accacattgc acttgctttt gcaaaataat cattccctgc   2760

ctagcacttc tcttctggcc atggaactaa gtacagtggc actgtttgag gaccagtgtt   2820

cccggggttc ctgtgtgccc ttatttctcc tggacttttc atttaagctc caagccccaa   2880

atctgggggg ctagtttaga aactctccct caacctagtt tagaaactct accccatctt   2940

taataccttg aatgttttga accccacttt ttaccttcat gggttgcaga aaaatcagaa   3000

cagatgtccc catccatgcg attgccccac catctactaa tgaaaaattg ttcttttttt   3060

catctttccc ctgcacttat gttactattc tctgctccca gccttcatcc ttttctaaaa   3120

aggagcaaat tctcactcta ggctttatcg tgtttacttt ttcattacac ttgacttgat   3180

tttctagttt tctatacaaa caccaatggg ttccatcttt ctgggctcct gattgctcaa   3240

gcacagtttg gcctgatgaa gaggatttca actacacaat actatcattg tcaggactat   3300

gacctcaggc actctaaaca tatgttttgt ttggtcagca cagcgtttca aaaagtgaag   3360

ccactttata aatatttgga gattttgcag gaaaatctgg atccccaggt aaggatagca   3420

gatggttttc agttatctcc agtccacgtt cacaaaatgt gaaggtgtgg agacacttac   3480

aaagctgcct cacttctcac tgtaaacatt agctctttcc actgcctacc tggaccccag   3540

tctaggaatt aaatctgcac ctaaccaagg tcccttgtaa gaaatgtcca ttcaagcagt   3600

cattctctgg gtatataata tgattttgac taccttatct ggtgttaaga tttgaagttg   3660

gccttttatt ggactaaagg ggaactcctt taagggtctc agttagccca agtttctttt   3720

gcttatatgt taatagtttt accctctgca ttggagagag gagtgcttta ctccaagaag   3780

ctttcctcat ggttaccgtt ctctccatca tgccagcctt ctcaaccttt gcagaaatta   3840

ctagagagga tttgaatgtg ggacacaaag gtcccatttg cagttagaaa atttgtgtcc   3900

acaaggacaa gaacaaagta tgagctttaa aactccatag gaaacttgtt aatcaacaaa   3960

gaagtgttaa tgctgcaagt aatctctttt ttaaaacttt ttgaagctac ttattttcag   4020

ccaaatagga atattagaga gggactggta gtgagaatat cagctctgtt tggatggtgg   4080

aaggtctcat tttattgaga tttttaagat acatgcaaag gtttggaaat agaacctcta   4140

ggcaccctcc tcagtgtggg tgggctgaga gttaaagaca gtgtggctgc agtagcatag   4200

aggcgcctag aaattccact tgcaccgtag ggcatgctga taccatccca atagctgttg   4260

cccattgacc tctagtggtg agtttctaga atactggtcc attcatgaga tattcaagat   4320

tcaagagtat tctcacttct gggttatcag cataaactgg aatgtagtgt cagaggatac   4380

tgtggcttgt tttgtttatg tttttttttc ttattcaaga aaaaagacca aggaataaca   4440

ttctgtagtt cctaaaaata ctgacttttt tcactactat acataaaggg aaagttttat   4500

tcttttatgg aacacttcag ctgtactcat gtattaaaat aggaatgtga atgctatata   4560

ctctttttat atcaaaagtc tcaagcactt atttttattc tatgcattgt ttgtctttta   4620

cataaataaa atgtttatta gattgaataa agcaaaatac tcaggtgagc atcctgcctc   4680

ctgttcccat tcctagtagc taaaaaaaaa aaaa                               4714


<210>  156
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    210                 215                 220                 


Thr Trp Glu Thr Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu His 
225                 230                 235                 240 


Cys Ala Ile Ile Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr Cys 
                245                 250                 255     


Ala Asn Asn Ile Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu Asp 
            260                 265                 270         


Thr Leu Val Gly Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys Leu 
        275                 280                 285             


Lys Gln Asn Thr Ser Glu Gln Phe Glu Thr Val Ala Val Lys Ile Phe 
    290                 295                 300                 


Pro Tyr Glu Glu Tyr Ala Ser Trp Lys Thr Glu Lys Asp Ile Phe Ser 
305                 310                 315                 320 


Asp Ile Asn Leu Lys His Glu Asn Ile Leu Gln Phe Leu Thr Ala Glu 
                325                 330                 335     


Glu Arg Lys Thr Glu Leu Gly Lys Gln Tyr Trp Leu Ile Thr Ala Phe 
            340                 345                 350         


His Ala Lys Gly Asn Leu Gln Glu Tyr Leu Thr Arg His Val Ile Ser 
        355                 360                 365             


Trp Glu Asp Leu Arg Lys Leu Gly Ser Ser Leu Ala Arg Gly Ile Ala 
    370                 375                 380                 


His Leu His Ser Asp His Thr Pro Cys Gly Arg Pro Lys Met Pro Ile 
385                 390                 395                 400 


Val His Arg Asp Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp Leu 
                405                 410                 415     


Thr Cys Cys Leu Cys Asp Phe Gly Leu Ser Leu Arg Leu Asp Pro Thr 
            420                 425                 430         


Leu Ser Val Asp Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala Arg 
        435                 440                 445             


Tyr Met Ala Pro Glu Val Leu Glu Ser Arg Met Asn Leu Glu Asn Val 
    450                 455                 460                 


Glu Ser Phe Lys Gln Thr Asp Val Tyr Ser Met Ala Leu Val Leu Trp 
465                 470                 475                 480 


Glu Met Thr Ser Arg Cys Asn Ala Val Gly Glu Val Lys Asp Tyr Glu 
                485                 490                 495     


Pro Pro Phe Gly Ser Lys Val Arg Glu His Pro Cys Val Glu Ser Met 
            500                 505                 510         


Lys Asp Asn Val Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Ser Phe 
        515                 520                 525             


Trp Leu Asn His Gln Gly Ile Gln Met Val Cys Glu Thr Leu Thr Glu 
    530                 535                 540                 


Cys Trp Asp His Asp Pro Glu Ala Arg Leu Thr Ala Gln Cys Val Ala 
545                 550                 555                 560 


Glu Arg Phe Ser Glu Leu Glu His Leu Asp Arg Leu Ser Gly Arg Ser 
                565                 570                 575     


Cys Ser Glu Glu Lys Ile Pro Glu Asp Gly Ser Leu Asn Thr Thr Lys 
            580                 585                 590         


<210>  157
<211>  3960
<212>  DNA
<213>  Homo sapiens

<400>  157
gttctgaatg atgactgacg cgggtttggg tgatacccct cacagcccct gtcattccgg     60

agtcataagg cacccgcgcg tctagcccca gcgccagggc acgcgagcgg cgctggaggg    120

aggaaagctt ccgcctgcgg gccggacaaa agtcccgcct gcccacggct ttttgcccgc    180

cgctcgtgac cgagacgcct cgccgcggcc agctcgctgc tctcgctggc ggatggtgtg    240

tggccgccgc aggacgcccg ccgtgcccgg gccatgaagt agcggctgct ggcggcgccg    300

ctgcccaacc gccagcccca gccccgcgct gcgctgcccg gtcctctccc ggcggggtcg    360

tatcggcgtg gacatggctg gccgcgtccc tagcctgcta gttctccttg tttttccaag    420

cagctgtttg gctttccgaa gcccactttc tgtctttaag aggtttaaag aaactaccag    480

accattttcc aatgaatgtc ttggtaccac cagacccgta gttcctattg attcatcaga    540

ttttgcattg gatattcgca tgcctggggt tacacctaaa cagtccgata catacttctg    600

catgtctatg cgaataccag tggatgagga agccttcgtg attgacttca agcctcgagc    660

cagcatggat actgtccatc acatgttact ttttggatgc aatatgcctt catccactgg    720

aagttactgg ttttgtgatg aaggaacctg tacagataaa gccaatattc tgtatgcctg    780

ggcgagaaat gctcccccta cccggctccc caaaggtgtt ggattcagag ttggaggaga    840

gactggaagt aaatactttg tactacaggt acactatggg gatattagtg cttttagaga    900

taataacaag gactgttctg gtgtgtcctt acacctcaca cgtctgccac agcctttaat    960

tgctggcatg taccttatga tgtctgttga cactgttatc ccagcaggag aaaaagtggt   1020

gaattctgac atttcatgcc attataaaaa ttatccaatg catgtctttg cctatagagt   1080

tcacactcac catttaggta aggtagtaag tggatacaga gtaagaaatg gacagtggac   1140

actgattgga cggcagagcc ctcagctgcc acaggctttc taccctgtgg ggcatccagt   1200

tgatgtaagt tttggtgacc tactggctgc aagatgtgta ttcactggtg aaggaaggac   1260

agaagccaca cacattggtg gcacgtctag tgatgaaatg tgcaacttat acattatgta   1320

ttacatggaa gccaagcatg cagtttcttt catgacctgt acccagaatg tagctccaga   1380

tatgttcaga accataccac cagaggccaa cattccaatt cccgtgaagt ctgatatggt   1440

tatgatgcat gaacatcata aagaaacaga atataaagat aagattcctt tactacagca   1500

gccaaaacga gaagaagaag aagtgttaga ccagggtgat ttctattcac tactttccaa   1560

gctgctagga gaaagggaag atgttgttca tgtgcacaaa tataatccta cagaaaaggc   1620

agaatcagag tcagacctgg tagctgagat tgcaaatgta gtccaaaaaa aggatcttgg   1680

tcgatctgat gccagagagg gtgcagaaca tgagaggggt aatgctattc ttgtcagaga   1740

cagaattcac aaattccaca gactagtatc taccttgagg ccaccagaga gcagagtttt   1800

ctcattacag cagcccccac ctggtgaagg cacctgggaa ccagaacaca caggagattt   1860

ccacatggaa gaggcactgg attggcctgg agtatacttg ttaccaggcc aggtttctgg   1920

ggtggctcta gaccctaaga ataacctggt gattttccac agaggtgacc atgtctggga   1980

tggaaactcg tttgacagca agtttgttta ccagcaaata ggactcggac caattgaaga   2040

agacactatt cttgtcatag atccaaataa tgctgcagta ctccagtcca gtggaaaaaa   2100

tctgttttac ttgccacatg gcttgagtat agataaagat gggaattatt gggtcacaga   2160

cgtggctctc catcaggtgt tcaaactgga tccaaacaat aaagaaggcc ctgtattaat   2220

cctgggaagg agcatgcaac caggcagtga ccagaatcac ttctgtcaac ccactgatgt   2280

ggctgtggat ccaggcactg gagccattta tgtatcagat ggttactgca acagcaggat   2340

tgtgcagttt tcaccaagtg gaaagttcat cacacagtgg ggagaagagt cttcagggag   2400

cagtcctctg ccaggccagt tcactgttcc tcacagcttg gctcttgtgc ctcttttggg   2460

ccaattatgt gtggcagacc gggaaaatgg tcggatccag tgttttaaaa ctgacaccaa   2520

agaatttgtg agagagatta agcattcatc atttggaaga aatgtatttg caatttcata   2580

tataccaggc ttgctctttg cagtgaatgg gaagcctcat tttggggacc aagaacctgt   2640

acaaggattt gtgatgaact tttccaatgg ggaaattata gacatcttca agccagtgcg   2700

caagcacttt gatatgcctc atgatattgt tgcatctgaa gatgggactg tgtacattgg   2760

agatgctcat accaacaccg tgtggaagtt caccttgact gagaaattgg aacatcgatc   2820

agttaaaaag gctggcattg aggtccagga aatcaaagaa gccgaggcag ttgttgaaac   2880

caaaatggag aacaaaccca cctcctcaga attgcagaag atgcaagaga aacagaaact   2940

gatcaaagag ccaggctcgg gagtgcctgt tgttctcatt acaacccttc tggttattcc   3000

ggtggttgtc ctgctggcca ttgccatatt tattcggtgg aaaaaatcaa gggcctttgg   3060

agcagattct gaacacaaac tcgagacgag ttcaggaaga gtactgggaa gatttagagg   3120

aaagggaagt ggaggcttaa accttggtaa tttctttgca agccgtaagg gctacagtcg   3180

aaaagggttt gaccggctta gcactgaggg cagtgaccaa gagaaagagg atgatggaag   3240

tgaatcagaa gaggagtatt cagcacctct gcctgcgctc gcaccttcct cctcctgaaa   3300

accaagcttt gatttagatt gagtaagatt tacccagaat gtcagattcc tttcccttta   3360

gcacgtttaa agttctgtgt atttaattgt aaactgtact agtctgtgtg ggactgtaca   3420

cactttattt acttcgtttt ggttaagttg gcttctgttt ctagttgagg agtttcctaa   3480

aagttcataa cagtgccatt gtctttatat gaacatagac tagagaaacc gtcctctttt   3540

tccatcataa ttctaatcta acaatggaag atttgcccat ttacactttt gagacttttt   3600

ggtggatgta aataacccca ttctttgctt gaacacagta ttttcccaat agcactttca   3660

ttgccagtgt ctttctttgg tgcctttcct gttcagcatt cttagcctgt ggcagtaaag   3720

agaaactttg tgctacatga cgacaaagct gctaaatctc ctattttttt aaaatcacta   3780

acattatatt gcaatgaagg aaataaaaaa gtctctattt aaattctttt ttaaattttc   3840

ttcagttggt gtgtttttgg gatgtcttat ttttagatgg ttacactgtt agaacactat   3900

tttcagaatc tgaatgtaat ttgtgtaata aagtgttttc agagcaaaaa aaaaaaaaaa   3960


<210>  158
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
            820                 825                 830         


Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
        835                 840                 845             


Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
    850                 855                 860                 


Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
865                 870                 875                 880 


Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                885                 890                 895     


Ala Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly 
            900                 905                 910         


Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe 
        915                 920                 925             


Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr 
    930                 935                 940                 


Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu 
945                 950                 955                 960 


Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                965                 970                 


<210>  159
<211>  1496
<212>  DNA
<213>  Homo sapiens

<400>  159
gctctaagcg cccggggccc cgcccagtgg ccggcacagc caatcgcagc gcgggaaggc     60

ggtgggggcg gggaaggccg cctggaaact taaatcccga ggcgggcgaa cctgcaccag    120

accgcggacg tctgtaatct cagaggcttg tttgctgagg gtgcctgcgc agctgcgacg    180

gctgctggtt ttgaaacatg aatctttcgc tcgtcctggc tgccttttgc ttgggaatag    240

cctccgctgt tccaaaattt gaccaaaatt tggatacaaa gtggtaccag tggaaggcaa    300

cacacagaag attatatggc gcgaatgaag aaggatggag gagagcagtg tgggaaaaga    360

atatgaaaat gattgaactg cacaatgggg aatacagcca agggaaacat ggcttcacaa    420

tggccatgaa tgcttttggt gacatgacca atgaagaatt caggcagatg atgggttgct    480

ttcgaaacca gaaattcagg aaggggaaag tgttccgtga gcctctgttt cttgatcttc    540

ccaaatctgt ggattggaga aagaaaggct acgtgacgcc agtgaagaat cagaaacagt    600

gtggttcttg ttgggctttt agtgcgactg gtgctcttga aggacagatg ttccggaaaa    660

ctgggaaact tgtctcactg agcgagcaga atctggtgga ctgttcgcgt cctcaaggca    720

atcagggctg caatggtggc ttcatggcta gggccttcca gtatgtcaag gagaacggag    780

gcctggactc tgaggaatcc tatccatatg tagcagtgga tgaaatctgt aagtacagac    840

ctgagaattc tgttgctaat gacactggct tcacagtggt cgcacctgga aaggagaagg    900

ccctgatgaa agcagtcgca actgtggggc ccatctccgt tgctatggat gcaggccatt    960

cgtccttcca gttctacaaa tcaggcattt attttgaacc agactgcagc agcaaaaacc   1020

tggatcatgg tgttctggtg gttggctacg gctttgaagg agcaaattcg aataacagca   1080

agtattggct cgtcaaaaac agctggggtc cagaatgggg ctcgaatggc tatgtaaaaa   1140

tagccaaaga caagaacaac cactgtggaa tcgccacagc agccagctac cccaatgtgt   1200

gagctgatgg atggtgagga ggaaggactt aaggacagca tgtctgggga aattttatct   1260

tgaaactgac caaacgctta ttgtgtaaga taaaccagtt gaatcattga ggatccaagt   1320

tgagatttta attctgtgac atttttacaa gggtaaaatg ttaccactac tttaattatt   1380

gttatacaca gctttatgat atcaaagact cattgcttaa ttctaagact tttgaatttt   1440

cattttttaa aaagatgtac aaaacagttt gaaataaatt ttaattcgta tataaa       1496


<210>  160
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr Gln Trp 
            20                  25                  30          


Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gly 
    50                  55                  60                  


Glu Tyr Ser Gln Gly Lys His Gly Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Met Met Gly Cys Phe Arg 
                85                  90                  95      


Asn Gln Lys Phe Arg Lys Gly Lys Val Phe Arg Glu Pro Leu Phe Leu 
            100                 105                 110         


Asp Leu Pro Lys Ser Val Asp Trp Arg Lys Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Lys Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Pro Gln Gly Asn Gln 
                165                 170                 175     


Gly Cys Asn Gly Gly Phe Met Ala Arg Ala Phe Gln Tyr Val Lys Glu 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Val Ala Val Asp 
        195                 200                 205             


Glu Ile Cys Lys Tyr Arg Pro Glu Asn Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Thr Val Val Ala Pro Gly Lys Glu Lys Ala Leu Met Lys Ala Val 
225                 230                 235                 240 


Ala Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Gly His Ser Ser 
                245                 250                 255     


Phe Gln Phe Tyr Lys Ser Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser 
            260                 265                 270         


Lys Asn Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly 
        275                 280                 285             


Ala Asn Ser Asn Asn Ser Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Glu Trp Gly Ser Asn Gly Tyr Val Lys Ile Ala Lys Asp Lys Asn 
305                 310                 315                 320 


Asn His Cys Gly Ile Ala Thr Ala Ala Ser Tyr Pro Asn Val 
                325                 330                 


<210>  161
<211>  11659
<212>  DNA
<213>  Homo sapiens

<400>  161
gctggaggga tcctccattc ctgtgtcatt tgcatgggtc ctgctgtgaa atgaacctgg     60

cagggacttg ttagacactt ccttccttcc ctcattgagc actccagtgc cattgttcca    120

cagttgttct aattgggtcc tagcttcctc ctgccaaggc aaacagcata gtctcgagta    180

ggtgtcccta ggctcatctg ccagcctgaa catgaacaca ggcaaagctg atgatggcca    240

gggaccccag gggacgtggg gccctgtggg gtctggcccc caggagcaag acctctgatg    300

atgctggtgt ctgggagtga gcaccatgcc catcacccag gacaatgccg tgctgcacct    360

gcccctcctc taccagtggc tgcagaacag cctgcaggaa ggtggggatg ggccggagca    420

gcggctctgc caggcggcca tccagaagct gcaggagtac atccagctga actttgctgt    480

ggatgagagt acggtcccac ctgatcacag cccccccgaa atggagatct gtactgtgta    540

cctcaccaag gagctggggg acacagagac tgtgggcctg agttttggga acatccctgt    600

tttcggggac tatggtgaaa agcgcagggg gggcaagaag aggaaaaccc accagggtcc    660

tgtgctggat gtgggctgca tctgggtgac agagctgagg aagaacagcc cagcagggaa    720

gagtgggaag gtccgactgc gggatgagat cctctcactg aatgggcagc tgatggttgg    780

agttgatgtc agtggggcca gttacctggc tgagcagtgc tggaatggcg gctttatcta    840

cctgatcatg ctgcgtcgct ttaagcacaa agcccactcc acttataatg gcaacagtag    900

caacagctct gaaccaggag aaacacctac cttggagctg ggtgaccgaa ctgcgaaaaa    960

ggggaaacga accagaaagt ttggggtcat ctccaggcct cctgccaaca aggcccctga   1020

agaatccaag ggcagcgctg gctgtgaggt gtccagtgac cccagcactg agctggagaa   1080

cggccctgac cctgaacttg gaaacggcca tgtctttcag ctagaaaatg gcccagattc   1140

tctcaaggag gtggctggac cccatctaga gaggtcagaa gtggacagag ggacagagca   1200

tagaattcca aagacagatg ctcctctgac cacaagcaat gacaaacgcc gcttctcaaa   1260

aggtgggaag acggacttcc aatcgagtga ctgcctggca cgggaggaag ttggccgaat   1320

atggaagatg gagctgctca aagaatcgga tgggctggga attcaggtta gtggaggccg   1380

aggatcaaag cgctcacctc acgctatcgt tgtcactcaa gtgaaggaag gaggtgccgc   1440

tcacagggat ggcaggctgt ccttaggaga tgagctgctg gtaatcaatg gtcatttact   1500

ggtcgggctc tcccacgagg aagcagtggc cattcttcgc tccgccacgg gaatggtgca   1560

gcttgtggtg gccagcaagg aaaactccgc agaggacctc ctcaggttaa catctaagag   1620

cttgccagat ctgaccagct cggtagaaga tgtgtcctcc tggactgata acgaagacca   1680

ggaggcagac ggggaagagg acgaaggaac cagctcttct gtccagagag caatgcctgg   1740

gacagatgaa ccccaagatg tgtgcggtgc tgaggaatcc aaggggaact tggaaagtcc   1800

caaacagggc agcaataaaa tcaagctcaa gagtcgcctt tcagggggtg tacaccgcct   1860

tgagtcagtt gaagaatata acgagctgat ggtgcggaat ggggaccccc ggatccggat   1920

gttggaggtc tcccgagatg gccggaaaca ctccctcccg cagctgctgg actcttccag   1980

tgcctcacag gaataccaca ttgtgaagaa gtctacccgc tccttaagca cgactcaggt   2040

ggaatctcct tggaggctca ttcggccatc cgtcatctcg atcattgggt tgtacaaaga   2100

aaaaggcaag ggccttggct ttagtattgc tggaggtcga gactgcattc gtggacagat   2160

ggggattttt gtcaagacca tcttcccaaa tggatcagct gcagaggacg gaagacttaa   2220

agaaggggat gaaatcctag atgtaaatgg aataccaata aagggcttga catttcaaga   2280

agccattcat acctttaagc aaatccggag tggattattt gttttaacgg tacgcacaaa   2340

gttggtgagc cccagcctca caccctgctc gacacccaca cacatgagca gatccgcctc   2400

cccgaacttc aataccagtg ggggagcctc agcgggaggt tccgatgaag gcagttcttc   2460

atccctgggt cggaagaccc ctgggcccaa ggacaggatc gtcatggaag taacactcaa   2520

caaagagcca agagttggat taggcattgg tgcctgctgc ttggctctgg aaaacagtcc   2580

tcctggcatc tacattcaca gccttgctcc aggatcagtg gccaagatgg agagcaacct   2640

gagccgcggg gatcaaatcc tggaagtgaa ctccgtcaac gtccgccatg ctgctttaag   2700

caaagtccac gccatcttga gtaaatgccc tccaggaccc gttcgccttg tcatcggccg   2760

gcaccctaat ccaaaggttt ccgagcagga aatggatgaa gtcatagcac gcagcactta   2820

tcaggagagc aaagaggcca attcctctcc tggcttaggt acccccttga agagtccctc   2880

tcttgcaaaa aaggactccc ttatttctga atctgaactc tcccagtact ttgcccacga   2940

tgtccctggc cccttgtcag acttcatggt ggccggttct gaggacgagg atcacccggg   3000

aagtggctgc agcacgtcgg aggagggcag cctgcctccc agcacctcca ctcacaagga   3060

gcctggaaaa cccagagcca acagcctcgt gactcttggg agccatcggg cttctgggct   3120

cttccacaag caggtgacag ttgccagaca agccagtctc cccggaagcc cacaggccct   3180

ccgaaaccct ctcctccgcc agaggaaggt aggctgctac gatgccaacg atgccagtga   3240

tgaggaagag tttgacagag aaggggactg catttcactc ccaggggccc tcccgggtcc   3300

catcaggcct ctgtcagagg atgacccgag gcgtgtctca atttcctctt ccaagggcat   3360

ggacgtccac aaccaagagg aacgaccccg gaaaacactg gtgagcaagg ccatctcggc   3420

acctcttctt ggtagctcag tggacttaga ggagagtatc ccagagggca tggtggatgc   3480

tgcgtcctat gcagccaacc tcacggactc tgcagaggcc cccaagggga gccctggaag   3540

ctggtggaag aaggaactgt caggatcaag tagcgcaccc aaattggaat acacagtccg   3600

tacagacacc cagagtccga cgaacactgg gagccccagt tccccccagc agaaaagtga   3660

aggcctgggc tccaggcaca gaccagtggc cagggtaagc ccccactgca agagatccga   3720

ggctgaggcc aagcccagtg gctcacagac agtgaacctg actggcagag ccaatgatcc   3780

atgcgatctg gactcgagag tccaggccac ttctgtcaaa gtgactgtcg ctggctttca   3840

gccaggtgga gctgtggaga aggaatctct gggaaagctg accactggag atgcttgtgt   3900

ctctaccagc tgtgaactag ccagtgctct gtcccatctg gatgccagcc acctcacaga   3960

gaacctgccc aaagctgcat cagagctggg gcaacaaccc atgactgaac tggacagctc   4020

ctcagacctc atctcttccc cagggaagaa gggggccgct catcctgacc ccagcaagac   4080

ctctgtagac acagggcaag tcagtcggcc agagaatccc agccagcctg catcgcccag   4140

ggtcaccaag tgcaaggcca ggtctccagt caggctcccc catgagggca gcccctcccc   4200

gggggagaaa gcagcggctc cccctgacta cagcaagact cgatcagcat cggaaaccag   4260

cacaccccac aataccagga gggtggctgc cctcagggga gcgggacctg gagcagaggg   4320

aatgacacca gctggtgctg tcctgccagg agaccccctc acatcccagg agcagagaca   4380

gggagctcca ggtaaccaca gtaaggctct ggaaatgaca ggaatccatg cacctgaaag   4440

ctcccaggag ccttccctgc tggagggagc agattctgtg tcctcaaggg caccgcaggc   4500

cagcctctcc atgctgccat ccactgacaa caccaaagaa gcatgtggcc atgtctcggg   4560

gcactgctgc ccagggggga gtagagagag ccctgtgacg gacattgaca gcttcatcaa   4620

ggagctggat gcttctgcag caaggtctcc gtcttcccag acgggggaca gtggctctca   4680

ggagggcagt gctcagggcc acccaccagc cggggctgga ggtgggagct cctgccgtgc   4740

cgaaccagtc ccggggggcc agacctcctc cccgaggagg gcctgggctg ctggtgcccc   4800

cgcctaccca caatgggcct cccagccttc ggttttagat tcaattaatc ccgacaaaca   4860

ttttactgtg aacaaaaact ttctgagcaa ctactctaga aattttagca gttttcatga   4920

agacagcacc tccctatcag gcctgggtga cagcacggag ccgtctctgt catccatgta   4980

tggcgatgct gaggattctt cttctgaccc tgagtcactc actgaagccc cacgagcttc   5040

tgccagggac ggctggtccc ctcctcgttc ccgtgtgtct ttgcacaagg aagatccttc   5100

ggagtcagaa gaggaacaga ttgagatttg ttccacacgt ggctgcccca atccaccctc   5160

gagtcctgct catcttccca cccaggctgc catctgtcct gcctcagcca aagttctgtc   5220

attaaaatac agcactccga gagagtcggt ggccagtccc cgtgagaagg ccgcctgctt   5280

gccaggctca tacacttcag gcccagactc ttcccagcca tcatcactct tggagatgag   5340

ctctcaggag catgaaactc atgcggacat aagcacttca cagaaccaca ggccctcgtg   5400

tgcagaagaa accacagaag tcaccagcgc tagctcagcc atggaaaaca gtccgctgtc   5460

taaagtagcc aggcattttc acagtccgcc catcattctc agctccccca acatggtaaa   5520

tggcttggaa catgacctgc tagatgacga aaccctgaat caatacgaaa caagcattaa   5580

tgcagctgcc agtctgtcct ccttcagtgt ggatgtccct aagaatggag aatctgtttt   5640

ggaaaacctc cacatctctg aaagtcaaga cctggatgac ttgctacaga aaccaaaaat   5700

gatcgctagg aggcccatca tggcctggtt taaagaaata aataaacata accaaggcac   5760

acatttgagg agcaaaaccg agaaggaaca acctctaatg cctgccagaa gtcccgactc   5820

caagattcag atggtgagtt caagccaaaa aaagggcgtt actgtgcctc atagccctcc   5880

tcagccgaaa acaaacctgg aaaataagga cctgtctaag aagagtccgg cagaaatgct   5940

tctgactaat ggtcagaagg caaagtgtgg tccgaagctg aagaggctca gcctcaaggg   6000

caaggccaaa gtcaactctg aggcccctgc tgcgaatgct gtgaaggctg gggggacgga   6060

ccacaggaaa cccttgatct caccccagac ctcccacaaa acactttcta aggcagtgtc   6120

acagcggctc catgtagccg accacgagga ccctgacaga aacaccacag ctgcccccag   6180

gtccccccag tgtgtgctgg aaagcaagcc acctcttgcc acctctgggc cactgaaacc   6240

ctcagtgtct gacacgagca tcaggacatt tgtctcgccc ctgacctctc ccaagcctgt   6300

tcctgagcaa ggcatgtgga gcaggttcca catggctgtc ctctctgaac ccgacagagg   6360

ttgcccaacc acccctaaat ctcctaagtg tagagcagag ggcagggcgc cccgtgctga   6420

ctccgggccg gtgagtccgg cagcgtctag gaacggcatg tccgtggcag ggaacagaca   6480

gagtgagccg cgcctggcca gccatgtggc agcagacaca gcccaaccca ggccgactgg   6540

cgaaaaagga ggcaacataa tggccagcga tcgcctcgaa agaacaaacc agctgaaaat   6600

cgtggagatt tctgctgaag cagtgtcaga gactgtatgt ggtaacaagc cagctgaaag   6660

cgacagacgg ggagggtgct tggcccaggg caactgtcag gagaagagtg aaatcaggct   6720

ctatcgccag gtcgcagaat catccacaag tcatccatcc tcactcccat ctcatgcctc   6780

ccaggcagag caggaaatgt cacgatcatt cagcatggca aaactggcgt cctcctcctc   6840

ctcccttcaa acagccatta gaaaggcaga atactcccag ggaaaatcaa gcctgatgtc   6900

agactcccga ggggtgccca gaaacagcat tccagggggc ccctcggggg aggaccatct   6960

ctacttcacc ccaaggccag cgaccaggac ctactccatg ccagcccagt tctcaagcca   7020

ttttggacgg gagggtcacc ccccacacag cctgggtcgc tctcgggaca gccaggtccc   7080

tgtgacaagc agtgttgtcc ccgaggcaaa ggcatccaga ggtggtcttc ccagcctggc   7140

taatggacag ggcatatata gtgtaaagcc gctgctggac acatcgagga atcttccagc   7200

cacagatgaa ggggatatca tttcagtcca ggagacgagc tgcctagtca cagacaaaat   7260

caaagtcacc agacgacact actgctatga gcagaactgg ccccatgaat ctacctcatt   7320

tttctctgtg aagcagcgga tcaagtcttt tgagaacctg gccaatgctg accggcctgt   7380

agccaagtcc ggggcttccc catttttgtc ggtgagctcc aagcctccca ttgggaggcg   7440

gtcttccggc agcattgttt ccgggagcct gggccaccca ggtgacgcag cagcaaggtt   7500

gttgagacgc agcttgagtt cctgcagcga aaaccaaagc gaagccggca ccctcctgcc   7560

ccagatggcc aagtctccct caatcatgac actgaccatc tctcggcaga acccaccaga   7620

gaccagtagc aagggctctg attcggaact aaagaaatca cttggtcctt tgggaattcc   7680

caccccaacg atgaccctgg cttctcctgt taagaggaac aagtcctcgg tacgccacac   7740

gcagccctcg cccgtgtccc gctccaagct ccaggagctg agagccttga gcatgcctga   7800

ccttgacaag ctctgcagcg aggattactc agcagggccg agcgccgtgc tcttcaaaac   7860

tgagctggag atcaccccca ggaggtcacc tggccctcct gctggaggcg tttcgtgtcc   7920

cgagaagggc gggaacaggg cctgtccagg aggaagtggc cctaaaacca gtgctgctga   7980

gacacccagt tcagccagtg atacgggtga agctgcccag gatctgcctt ttagaagaag   8040

ctggtcagtt aatttggatc aacttctagt ctcagcgggg gaccagcaaa gattacagtc   8100

tgttttatcg tcagtgggat cgaaatctac catcctaact ctcattcagg aagcgaaagc   8160

acaatcagag aatgaagaag atgtttgctt catagtcttg aatagaaaag aaggctcagg   8220

tctgggattc agtgtggcag gagggacaga tgtggagcca aaatcaatca cggtccacag   8280

ggtgttttct cagggggcgg cttctcagga agggactatg aaccgagggg atttccttct   8340

gtcagtcaac ggcgcctcac tggctggctt agcccacggg aatgtcctga aggttctgca   8400

ccaggcacag ctgcacaaag atgccctcgt ggtcatcaag aaagggatgg atcagcccag   8460

gccctctgcc cggcaggagc ctcccacagc caatgggaag ggtttgctgt ccagaaagac   8520

catccccctg gagcctggca ttgggagaag tgtggctgta cacgatgctc tgtgtgttga   8580

agtgctgaag acctcggctg ggctgggact gagtctggat gggggaaaat catcggtgac   8640

gggagatggg cccttggtca ttaaaagagt gtacaaaggt ggtgcggctg aacaagctgg   8700

aataatagaa gctggagatg aaattcttgc tattaatggg aaacctctgg ttgggctcat   8760

gcactttgat gcctggaata ttatgaagtc tgtcccagaa ggacctgtgc agttattaat   8820

tagaaagcat aggaattctt catgaatttt aacaagaatc attttctcag ttctcttctt   8880

tctttagcaa atcagagtga cttctttaaa ccacaggttg ttgaaatggc caacactggt   8940

acagacacgg actataaaaa tctccaagct tgtgcttaca catgaagcct gacttaactg   9000

tatgtgcaac agcaatgaaa ttaactccag aagccttcca cctgcgtcac ccaggccggg   9060

agggttcctt cgttccagtg cctgtcccct acctttatgt tatgtttact gatggggata   9120

caagatgtga cacacccttc tttatttgaa acaaacaaac atttagctag acctttgctt   9180

ccttcttgcc agctctccca acatacccaa tcctggtgat cagggaacta aaagtctgag   9240

ggggacacaa atgtcacacc taagaggaca atcaatcatt ttgtatgatt ttgtaagtaa   9300

atgacagaat gcttttaggc acattcaatg gaaggaggag atgtaggtct gtatatgtta   9360

ccctgaaaag agaataagac ttacttaaaa aaatgaatta tgacctgtta ggctgagctc   9420

aggaattgtc caaaaaggaa aaagcaaaat aattaattga gagtattttt tagtgagtgt   9480

aatgtataat gtacgtatgc aaagttcaac tcaataggtt attgatcacc atgaagtatt   9540

gatcattttc tatctcaaaa gtgtaagcca taaggctgtt ttacagaata gcacttctga   9600

taagctgtat taaatagcca tgagcttcac tgcttagagg gagcagaaag gtcaacatct   9660

aaaagcacct tacaactagt ttttgaacct gtcttgataa gtgcttgaat tcaagactgg   9720

tcagtccaag agcagacaaa aatatcacaa gtcagtcagt cactgggttt ccatttctga   9780

attttatgca ctccaaccat gaatttaaac taaattttta gaaatcaagt atctttctaa   9840

gtgtccttgg atttatagac aatgtatgta caatccaaat agaggagctt aatggaatcc   9900

ttttaggaga ctggttggtt tttttccctc tttcccaaca tgtttaagaa atgtaacatt   9960

ctaagtattg gatctctttt cttgacctag tataatgaca actgcagtga cttaagtttt  10020

tgctgttttc gttttcccgc tttgcaattt cctccttttg ccaaaaatgt tttcctacag  10080

aagactgtcg tgactcacgc tacttgggaa actcactctg gccactcctc ctctggtggc  10140

atgagctgct tcccagtagc tattccgatt ggatattccg ttcgtcgtca catagctggc  10200

ttttctctcc tcatgatgta ccttattttc ttaggtaaat aattccaaac tctcatcggg  10260

tcataaagag gaggagaaac agggtgagtc aaggtaaagg agcagaaatg tagttacaag  10320

ccaggtcgtc ttcagtggca caaaccaacc cgttgagccc tgacaacatg agtggagagt  10380

gcatttgcca tacctgtgtg catgacacta agattttatg ttggagatac ttctttaaat  10440

aacctacagc ttgggtctat ggctgtgacc cccagattca tggaggggct ttagccatca  10500

gctttgtaca tcatcatttt tctgaatgac caatcccact aaacatcttt gaagtcggcc  10560

tagagaggtc cttcagatga gagagaaata gctggcttgt ctgagtccag atttctcatc  10620

aactggcaat acaaaggaaa atatggtaca ggagttagtt agaaaggtct tattgatttt  10680

acttctactt ttcactacag ttacaggtag aatactgtag gaagtcagtg caaggtgcat  10740

gcttgattga tagatattga ttgattgttt ttcagtctct ggggtcagtt ttgtggtttc  10800

tgctttcttg cctaaatcaa agactatttc aagtcaacaa cactgaaaac tgcttttcgc  10860

ctccactctt acagctgtgc ctaataataa ttaattaata aacgcacagc cctatgtgaa  10920

cagacaggaa tttcttgtgc aatgtggagc aaatggaatg gtctccttcc gcaagtcttt  10980

ttaatcctca tatctggagt acaagggtag acctctggct taccacatac actatgctaa  11040

agtcatcagc cactgctact acatcttgcc agaaggtttc cctcgccaac aaacagttga  11100

aatttaaggg aagaagcaaa agctaaactg tctttgaccc taagatagat agaaagctat  11160

ttatttgtct tcagtgttca aggcatgact agtatttcta attagcctaa taaattccca  11220

cactttctga agtgaacact aatggtattg tcctactaaa actgtcattg tttctttttt  11280

tttaactggt cagtcattca caataagcta tgagggtaaa taaatatgtg ttataacaag  11340

taaaccgtag ttgcaagaat ataccatgaa gattaaagta ggctgggttt catttccatc  11400

ttcccacaca tctcattgaa tttgatggtt gacttaattg gcaccataac tttgtatgat  11460

attatacatt aacctttatt tatgtaaagt aaaatgcctt atatattaaa gagtaagtgc  11520

aataatatga aatagcctgt acattttaaa aatgttgtca ccaagttata taaatccaca  11580

tctctgtaaa caaccttttt taagtaattt taaaaaaaat aaacactctg cttactactt  11640

gaaaaaaaaa aaaaaaaaa                                               11659


<210>  162
<211>  2839
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Pro Ile Thr Gln Asp Asn Ala Val Leu His Leu Pro Leu Leu Tyr 
1               5                   10                  15      


Gln Trp Leu Gln Asn Ser Leu Gln Glu Gly Gly Asp Gly Pro Glu Gln 
            20                  25                  30          


Arg Leu Cys Gln Ala Ala Ile Gln Lys Leu Gln Glu Tyr Ile Gln Leu 
        35                  40                  45              


Asn Phe Ala Val Asp Glu Ser Thr Val Pro Pro Asp His Ser Pro Pro 
    50                  55                  60                  


Glu Met Glu Ile Cys Thr Val Tyr Leu Thr Lys Glu Leu Gly Asp Thr 
65                  70                  75                  80  


Glu Thr Val Gly Leu Ser Phe Gly Asn Ile Pro Val Phe Gly Asp Tyr 
                85                  90                  95      


Gly Glu Lys Arg Arg Gly Gly Lys Lys Arg Lys Thr His Gln Gly Pro 
            100                 105                 110         


Val Leu Asp Val Gly Cys Ile Trp Val Thr Glu Leu Arg Lys Asn Ser 
        115                 120                 125             


Pro Ala Gly Lys Ser Gly Lys Val Arg Leu Arg Asp Glu Ile Leu Ser 
    130                 135                 140                 


Leu Asn Gly Gln Leu Met Val Gly Val Asp Val Ser Gly Ala Ser Tyr 
145                 150                 155                 160 


Leu Ala Glu Gln Cys Trp Asn Gly Gly Phe Ile Tyr Leu Ile Met Leu 
                165                 170                 175     


Arg Arg Phe Lys His Lys Ala His Ser Thr Tyr Asn Gly Asn Ser Ser 
            180                 185                 190         


Asn Ser Ser Glu Pro Gly Glu Thr Pro Thr Leu Glu Leu Gly Asp Arg 
        195                 200                 205             


Thr Ala Lys Lys Gly Lys Arg Thr Arg Lys Phe Gly Val Ile Ser Arg 
    210                 215                 220                 


Pro Pro Ala Asn Lys Ala Pro Glu Glu Ser Lys Gly Ser Ala Gly Cys 
225                 230                 235                 240 


Glu Val Ser Ser Asp Pro Ser Thr Glu Leu Glu Asn Gly Pro Asp Pro 
                245                 250                 255     


Glu Leu Gly Asn Gly His Val Phe Gln Leu Glu Asn Gly Pro Asp Ser 
            260                 265                 270         


Leu Lys Glu Val Ala Gly Pro His Leu Glu Arg Ser Glu Val Asp Arg 
        275                 280                 285             


Gly Thr Glu His Arg Ile Pro Lys Thr Asp Ala Pro Leu Thr Thr Ser 
    290                 295                 300                 


Asn Asp Lys Arg Arg Phe Ser Lys Gly Gly Lys Thr Asp Phe Gln Ser 
305                 310                 315                 320 


Ser Asp Cys Leu Ala Arg Glu Glu Val Gly Arg Ile Trp Lys Met Glu 
                325                 330                 335     


Leu Leu Lys Glu Ser Asp Gly Leu Gly Ile Gln Val Ser Gly Gly Arg 
            340                 345                 350         


Gly Ser Lys Arg Ser Pro His Ala Ile Val Val Thr Gln Val Lys Glu 
        355                 360                 365             


Gly Gly Ala Ala His Arg Asp Gly Arg Leu Ser Leu Gly Asp Glu Leu 
    370                 375                 380                 


Leu Val Ile Asn Gly His Leu Leu Val Gly Leu Ser His Glu Glu Ala 
385                 390                 395                 400 


Val Ala Ile Leu Arg Ser Ala Thr Gly Met Val Gln Leu Val Val Ala 
                405                 410                 415     


Ser Lys Glu Asn Ser Ala Glu Asp Leu Leu Arg Leu Thr Ser Lys Ser 
            420                 425                 430         


Leu Pro Asp Leu Thr Ser Ser Val Glu Asp Val Ser Ser Trp Thr Asp 
        435                 440                 445             


Asn Glu Asp Gln Glu Ala Asp Gly Glu Glu Asp Glu Gly Thr Ser Ser 
    450                 455                 460                 


Ser Val Gln Arg Ala Met Pro Gly Thr Asp Glu Pro Gln Asp Val Cys 
465                 470                 475                 480 


Gly Ala Glu Glu Ser Lys Gly Asn Leu Glu Ser Pro Lys Gln Gly Ser 
                485                 490                 495     


Asn Lys Ile Lys Leu Lys Ser Arg Leu Ser Gly Gly Val His Arg Leu 
            500                 505                 510         


Glu Ser Val Glu Glu Tyr Asn Glu Leu Met Val Arg Asn Gly Asp Pro 
        515                 520                 525             


Arg Ile Arg Met Leu Glu Val Ser Arg Asp Gly Arg Lys His Ser Leu 
    530                 535                 540                 


Pro Gln Leu Leu Asp Ser Ser Ser Ala Ser Gln Glu Tyr His Ile Val 
545                 550                 555                 560 


Lys Lys Ser Thr Arg Ser Leu Ser Thr Thr Gln Val Glu Ser Pro Trp 
                565                 570                 575     


Arg Leu Ile Arg Pro Ser Val Ile Ser Ile Ile Gly Leu Tyr Lys Glu 
            580                 585                 590         


Lys Gly Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Arg Asp Cys Ile 
        595                 600                 605             


Arg Gly Gln Met Gly Ile Phe Val Lys Thr Ile Phe Pro Asn Gly Ser 
    610                 615                 620                 


Ala Ala Glu Asp Gly Arg Leu Lys Glu Gly Asp Glu Ile Leu Asp Val 
625                 630                 635                 640 


Asn Gly Ile Pro Ile Lys Gly Leu Thr Phe Gln Glu Ala Ile His Thr 
                645                 650                 655     


Phe Lys Gln Ile Arg Ser Gly Leu Phe Val Leu Thr Val Arg Thr Lys 
            660                 665                 670         


Leu Val Ser Pro Ser Leu Thr Pro Cys Ser Thr Pro Thr His Met Ser 
        675                 680                 685             


Arg Ser Ala Ser Pro Asn Phe Asn Thr Ser Gly Gly Ala Ser Ala Gly 
    690                 695                 700                 


Gly Ser Asp Glu Gly Ser Ser Ser Ser Leu Gly Arg Lys Thr Pro Gly 
705                 710                 715                 720 


Pro Lys Asp Arg Ile Val Met Glu Val Thr Leu Asn Lys Glu Pro Arg 
                725                 730                 735     


Val Gly Leu Gly Ile Gly Ala Cys Cys Leu Ala Leu Glu Asn Ser Pro 
            740                 745                 750         


Pro Gly Ile Tyr Ile His Ser Leu Ala Pro Gly Ser Val Ala Lys Met 
        755                 760                 765             


Glu Ser Asn Leu Ser Arg Gly Asp Gln Ile Leu Glu Val Asn Ser Val 
    770                 775                 780                 


Asn Val Arg His Ala Ala Leu Ser Lys Val His Ala Ile Leu Ser Lys 
785                 790                 795                 800 


Cys Pro Pro Gly Pro Val Arg Leu Val Ile Gly Arg His Pro Asn Pro 
                805                 810                 815     


Lys Val Ser Glu Gln Glu Met Asp Glu Val Ile Ala Arg Ser Thr Tyr 
            820                 825                 830         


Gln Glu Ser Lys Glu Ala Asn Ser Ser Pro Gly Leu Gly Thr Pro Leu 
        835                 840                 845             


Lys Ser Pro Ser Leu Ala Lys Lys Asp Ser Leu Ile Ser Glu Ser Glu 
    850                 855                 860                 


Leu Ser Gln Tyr Phe Ala His Asp Val Pro Gly Pro Leu Ser Asp Phe 
865                 870                 875                 880 


Met Val Ala Gly Ser Glu Asp Glu Asp His Pro Gly Ser Gly Cys Ser 
                885                 890                 895     


Thr Ser Glu Glu Gly Ser Leu Pro Pro Ser Thr Ser Thr His Lys Glu 
            900                 905                 910         


Pro Gly Lys Pro Arg Ala Asn Ser Leu Val Thr Leu Gly Ser His Arg 
        915                 920                 925             


Ala Ser Gly Leu Phe His Lys Gln Val Thr Val Ala Arg Gln Ala Ser 
    930                 935                 940                 


Leu Pro Gly Ser Pro Gln Ala Leu Arg Asn Pro Leu Leu Arg Gln Arg 
945                 950                 955                 960 


Lys Val Gly Cys Tyr Asp Ala Asn Asp Ala Ser Asp Glu Glu Glu Phe 
                965                 970                 975     


Asp Arg Glu Gly Asp Cys Ile Ser Leu Pro Gly Ala Leu Pro Gly Pro 
            980                 985                 990         


Ile Arg Pro Leu Ser Glu Asp Asp  Pro Arg Arg Val Ser  Ile Ser Ser 
        995                 1000                 1005             


Ser Lys  Gly Met Asp Val His  Asn Gln Glu Glu Arg  Pro Arg Lys 
    1010                 1015                 1020             


Thr Leu  Val Ser Lys Ala Ile  Ser Ala Pro Leu Leu  Gly Ser Ser 
    1025                 1030                 1035             


Val Asp  Leu Glu Glu Ser Ile  Pro Glu Gly Met Val  Asp Ala Ala 
    1040                 1045                 1050             


Ser Tyr  Ala Ala Asn Leu Thr  Asp Ser Ala Glu Ala  Pro Lys Gly 
    1055                 1060                 1065             


Ser Pro  Gly Ser Trp Trp Lys  Lys Glu Leu Ser Gly  Ser Ser Ser 
    1070                 1075                 1080             


Ala Pro  Lys Leu Glu Tyr Thr  Val Arg Thr Asp Thr  Gln Ser Pro 
    1085                 1090                 1095             


Thr Asn  Thr Gly Ser Pro Ser  Ser Pro Gln Gln Lys  Ser Glu Gly 
    1100                 1105                 1110             


Leu Gly  Ser Arg His Arg Pro  Val Ala Arg Val Ser  Pro His Cys 
    1115                 1120                 1125             


Lys Arg  Ser Glu Ala Glu Ala  Lys Pro Ser Gly Ser  Gln Thr Val 
    1130                 1135                 1140             


Asn Leu  Thr Gly Arg Ala Asn  Asp Pro Cys Asp Leu  Asp Ser Arg 
    1145                 1150                 1155             


Val Gln  Ala Thr Ser Val Lys  Val Thr Val Ala Gly  Phe Gln Pro 
    1160                 1165                 1170             


Gly Gly  Ala Val Glu Lys Glu  Ser Leu Gly Lys Leu  Thr Thr Gly 
    1175                 1180                 1185             


Asp Ala  Cys Val Ser Thr Ser  Cys Glu Leu Ala Ser  Ala Leu Ser 
    1190                 1195                 1200             


His Leu  Asp Ala Ser His Leu  Thr Glu Asn Leu Pro  Lys Ala Ala 
    1205                 1210                 1215             


Ser Glu  Leu Gly Gln Gln Pro  Met Thr Glu Leu Asp  Ser Ser Ser 
    1220                 1225                 1230             


Asp Leu  Ile Ser Ser Pro Gly  Lys Lys Gly Ala Ala  His Pro Asp 
    1235                 1240                 1245             


Pro Ser  Lys Thr Ser Val Asp  Thr Gly Gln Val Ser  Arg Pro Glu 
    1250                 1255                 1260             


Asn Pro  Ser Gln Pro Ala Ser  Pro Arg Val Thr Lys  Cys Lys Ala 
    1265                 1270                 1275             


Arg Ser  Pro Val Arg Leu Pro  His Glu Gly Ser Pro  Ser Pro Gly 
    1280                 1285                 1290             


Glu Lys  Ala Ala Ala Pro Pro  Asp Tyr Ser Lys Thr  Arg Ser Ala 
    1295                 1300                 1305             


Ser Glu  Thr Ser Thr Pro His  Asn Thr Arg Arg Val  Ala Ala Leu 
    1310                 1315                 1320             


Arg Gly  Ala Gly Pro Gly Ala  Glu Gly Met Thr Pro  Ala Gly Ala 
    1325                 1330                 1335             


Val Leu  Pro Gly Asp Pro Leu  Thr Ser Gln Glu Gln  Arg Gln Gly 
    1340                 1345                 1350             


Ala Pro  Gly Asn His Ser Lys  Ala Leu Glu Met Thr  Gly Ile His 
    1355                 1360                 1365             


Ala Pro  Glu Ser Ser Gln Glu  Pro Ser Leu Leu Glu  Gly Ala Asp 
    1370                 1375                 1380             


Ser Val  Ser Ser Arg Ala Pro  Gln Ala Ser Leu Ser  Met Leu Pro 
    1385                 1390                 1395             


Ser Thr  Asp Asn Thr Lys Glu  Ala Cys Gly His Val  Ser Gly His 
    1400                 1405                 1410             


Cys Cys  Pro Gly Gly Ser Arg  Glu Ser Pro Val Thr  Asp Ile Asp 
    1415                 1420                 1425             


Ser Phe  Ile Lys Glu Leu Asp  Ala Ser Ala Ala Arg  Ser Pro Ser 
    1430                 1435                 1440             


Ser Gln  Thr Gly Asp Ser Gly  Ser Gln Glu Gly Ser  Ala Gln Gly 
    1445                 1450                 1455             


His Pro  Pro Ala Gly Ala Gly  Gly Gly Ser Ser Cys  Arg Ala Glu 
    1460                 1465                 1470             


Pro Val  Pro Gly Gly Gln Thr  Ser Ser Pro Arg Arg  Ala Trp Ala 
    1475                 1480                 1485             


Ala Gly  Ala Pro Ala Tyr Pro  Gln Trp Ala Ser Gln  Pro Ser Val 
    1490                 1495                 1500             


Leu Asp  Ser Ile Asn Pro Asp  Lys His Phe Thr Val  Asn Lys Asn 
    1505                 1510                 1515             


Phe Leu  Ser Asn Tyr Ser Arg  Asn Phe Ser Ser Phe  His Glu Asp 
    1520                 1525                 1530             


Ser Thr  Ser Leu Ser Gly Leu  Gly Asp Ser Thr Glu  Pro Ser Leu 
    1535                 1540                 1545             


Ser Ser  Met Tyr Gly Asp Ala  Glu Asp Ser Ser Ser  Asp Pro Glu 
    1550                 1555                 1560             


Ser Leu  Thr Glu Ala Pro Arg  Ala Ser Ala Arg Asp  Gly Trp Ser 
    1565                 1570                 1575             


Pro Pro  Arg Ser Arg Val Ser  Leu His Lys Glu Asp  Pro Ser Glu 
    1580                 1585                 1590             


Ser Glu  Glu Glu Gln Ile Glu  Ile Cys Ser Thr Arg  Gly Cys Pro 
    1595                 1600                 1605             


Asn Pro  Pro Ser Ser Pro Ala  His Leu Pro Thr Gln  Ala Ala Ile 
    1610                 1615                 1620             


Cys Pro  Ala Ser Ala Lys Val  Leu Ser Leu Lys Tyr  Ser Thr Pro 
    1625                 1630                 1635             


Arg Glu  Ser Val Ala Ser Pro  Arg Glu Lys Ala Ala  Cys Leu Pro 
    1640                 1645                 1650             


Gly Ser  Tyr Thr Ser Gly Pro  Asp Ser Ser Gln Pro  Ser Ser Leu 
    1655                 1660                 1665             


Leu Glu  Met Ser Ser Gln Glu  His Glu Thr His Ala  Asp Ile Ser 
    1670                 1675                 1680             


Thr Ser  Gln Asn His Arg Pro  Ser Cys Ala Glu Glu  Thr Thr Glu 
    1685                 1690                 1695             


Val Thr  Ser Ala Ser Ser Ala  Met Glu Asn Ser Pro  Leu Ser Lys 
    1700                 1705                 1710             


Val Ala  Arg His Phe His Ser  Pro Pro Ile Ile Leu  Ser Ser Pro 
    1715                 1720                 1725             


Asn Met  Val Asn Gly Leu Glu  His Asp Leu Leu Asp  Asp Glu Thr 
    1730                 1735                 1740             


Leu Asn  Gln Tyr Glu Thr Ser  Ile Asn Ala Ala Ala  Ser Leu Ser 
    1745                 1750                 1755             


Ser Phe  Ser Val Asp Val Pro  Lys Asn Gly Glu Ser  Val Leu Glu 
    1760                 1765                 1770             


Asn Leu  His Ile Ser Glu Ser  Gln Asp Leu Asp Asp  Leu Leu Gln 
    1775                 1780                 1785             


Lys Pro  Lys Met Ile Ala Arg  Arg Pro Ile Met Ala  Trp Phe Lys 
    1790                 1795                 1800             


Glu Ile  Asn Lys His Asn Gln  Gly Thr His Leu Arg  Ser Lys Thr 
    1805                 1810                 1815             


Glu Lys  Glu Gln Pro Leu Met  Pro Ala Arg Ser Pro  Asp Ser Lys 
    1820                 1825                 1830             


Ile Gln  Met Val Ser Ser Ser  Gln Lys Lys Gly Val  Thr Val Pro 
    1835                 1840                 1845             


His Ser  Pro Pro Gln Pro Lys  Thr Asn Leu Glu Asn  Lys Asp Leu 
    1850                 1855                 1860             


Ser Lys  Lys Ser Pro Ala Glu  Met Leu Leu Thr Asn  Gly Gln Lys 
    1865                 1870                 1875             


Ala Lys  Cys Gly Pro Lys Leu  Lys Arg Leu Ser Leu  Lys Gly Lys 
    1880                 1885                 1890             


Ala Lys  Val Asn Ser Glu Ala  Pro Ala Ala Asn Ala  Val Lys Ala 
    1895                 1900                 1905             


Gly Gly  Thr Asp His Arg Lys  Pro Leu Ile Ser Pro  Gln Thr Ser 
    1910                 1915                 1920             


His Lys  Thr Leu Ser Lys Ala  Val Ser Gln Arg Leu  His Val Ala 
    1925                 1930                 1935             


Asp His  Glu Asp Pro Asp Arg  Asn Thr Thr Ala Ala  Pro Arg Ser 
    1940                 1945                 1950             


Pro Gln  Cys Val Leu Glu Ser  Lys Pro Pro Leu Ala  Thr Ser Gly 
    1955                 1960                 1965             


Pro Leu  Lys Pro Ser Val Ser  Asp Thr Ser Ile Arg  Thr Phe Val 
    1970                 1975                 1980             


Ser Pro  Leu Thr Ser Pro Lys  Pro Val Pro Glu Gln  Gly Met Trp 
    1985                 1990                 1995             


Ser Arg  Phe His Met Ala Val  Leu Ser Glu Pro Asp  Arg Gly Cys 
    2000                 2005                 2010             


Pro Thr  Thr Pro Lys Ser Pro  Lys Cys Arg Ala Glu  Gly Arg Ala 
    2015                 2020                 2025             


Pro Arg  Ala Asp Ser Gly Pro  Val Ser Pro Ala Ala  Ser Arg Asn 
    2030                 2035                 2040             


Gly Met  Ser Val Ala Gly Asn  Arg Gln Ser Glu Pro  Arg Leu Ala 
    2045                 2050                 2055             


Ser His  Val Ala Ala Asp Thr  Ala Gln Pro Arg Pro  Thr Gly Glu 
    2060                 2065                 2070             


Lys Gly  Gly Asn Ile Met Ala  Ser Asp Arg Leu Glu  Arg Thr Asn 
    2075                 2080                 2085             


Gln Leu  Lys Ile Val Glu Ile  Ser Ala Glu Ala Val  Ser Glu Thr 
    2090                 2095                 2100             


Val Cys  Gly Asn Lys Pro Ala  Glu Ser Asp Arg Arg  Gly Gly Cys 
    2105                 2110                 2115             


Leu Ala  Gln Gly Asn Cys Gln  Glu Lys Ser Glu Ile  Arg Leu Tyr 
    2120                 2125                 2130             


Arg Gln  Val Ala Glu Ser Ser  Thr Ser His Pro Ser  Ser Leu Pro 
    2135                 2140                 2145             


Ser His  Ala Ser Gln Ala Glu  Gln Glu Met Ser Arg  Ser Phe Ser 
    2150                 2155                 2160             


Met Ala  Lys Leu Ala Ser Ser  Ser Ser Ser Leu Gln  Thr Ala Ile 
    2165                 2170                 2175             


Arg Lys  Ala Glu Tyr Ser Gln  Gly Lys Ser Ser Leu  Met Ser Asp 
    2180                 2185                 2190             


Ser Arg  Gly Val Pro Arg Asn  Ser Ile Pro Gly Gly  Pro Ser Gly 
    2195                 2200                 2205             


Glu Asp  His Leu Tyr Phe Thr  Pro Arg Pro Ala Thr  Arg Thr Tyr 
    2210                 2215                 2220             


Ser Met  Pro Ala Gln Phe Ser  Ser His Phe Gly Arg  Glu Gly His 
    2225                 2230                 2235             


Pro Pro  His Ser Leu Gly Arg  Ser Arg Asp Ser Gln  Val Pro Val 
    2240                 2245                 2250             


Thr Ser  Ser Val Val Pro Glu  Ala Lys Ala Ser Arg  Gly Gly Leu 
    2255                 2260                 2265             


Pro Ser  Leu Ala Asn Gly Gln  Gly Ile Tyr Ser Val  Lys Pro Leu 
    2270                 2275                 2280             


Leu Asp  Thr Ser Arg Asn Leu  Pro Ala Thr Asp Glu  Gly Asp Ile 
    2285                 2290                 2295             


Ile Ser  Val Gln Glu Thr Ser  Cys Leu Val Thr Asp  Lys Ile Lys 
    2300                 2305                 2310             


Val Thr  Arg Arg His Tyr Cys  Tyr Glu Gln Asn Trp  Pro His Glu 
    2315                 2320                 2325             


Ser Thr  Ser Phe Phe Ser Val  Lys Gln Arg Ile Lys  Ser Phe Glu 
    2330                 2335                 2340             


Asn Leu  Ala Asn Ala Asp Arg  Pro Val Ala Lys Ser  Gly Ala Ser 
    2345                 2350                 2355             


Pro Phe  Leu Ser Val Ser Ser  Lys Pro Pro Ile Gly  Arg Arg Ser 
    2360                 2365                 2370             


Ser Gly  Ser Ile Val Ser Gly  Ser Leu Gly His Pro  Gly Asp Ala 
    2375                 2380                 2385             


Ala Ala  Arg Leu Leu Arg Arg  Ser Leu Ser Ser Cys  Ser Glu Asn 
    2390                 2395                 2400             


Gln Ser  Glu Ala Gly Thr Leu  Leu Pro Gln Met Ala  Lys Ser Pro 
    2405                 2410                 2415             


Ser Ile  Met Thr Leu Thr Ile  Ser Arg Gln Asn Pro  Pro Glu Thr 
    2420                 2425                 2430             


Ser Ser  Lys Gly Ser Asp Ser  Glu Leu Lys Lys Ser  Leu Gly Pro 
    2435                 2440                 2445             


Leu Gly  Ile Pro Thr Pro Thr  Met Thr Leu Ala Ser  Pro Val Lys 
    2450                 2455                 2460             


Arg Asn  Lys Ser Ser Val Arg  His Thr Gln Pro Ser  Pro Val Ser 
    2465                 2470                 2475             


Arg Ser  Lys Leu Gln Glu Leu  Arg Ala Leu Ser Met  Pro Asp Leu 
    2480                 2485                 2490             


Asp Lys  Leu Cys Ser Glu Asp  Tyr Ser Ala Gly Pro  Ser Ala Val 
    2495                 2500                 2505             


Leu Phe  Lys Thr Glu Leu Glu  Ile Thr Pro Arg Arg  Ser Pro Gly 
    2510                 2515                 2520             


Pro Pro  Ala Gly Gly Val Ser  Cys Pro Glu Lys Gly  Gly Asn Arg 
    2525                 2530                 2535             


Ala Cys  Pro Gly Gly Ser Gly  Pro Lys Thr Ser Ala  Ala Glu Thr 
    2540                 2545                 2550             


Pro Ser  Ser Ala Ser Asp Thr  Gly Glu Ala Ala Gln  Asp Leu Pro 
    2555                 2560                 2565             


Phe Arg  Arg Ser Trp Ser Val  Asn Leu Asp Gln Leu  Leu Val Ser 
    2570                 2575                 2580             


Ala Gly  Asp Gln Gln Arg Leu  Gln Ser Val Leu Ser  Ser Val Gly 
    2585                 2590                 2595             


Ser Lys  Ser Thr Ile Leu Thr  Leu Ile Gln Glu Ala  Lys Ala Gln 
    2600                 2605                 2610             


Ser Glu  Asn Glu Glu Asp Val  Cys Phe Ile Val Leu  Asn Arg Lys 
    2615                 2620                 2625             


Glu Gly  Ser Gly Leu Gly Phe  Ser Val Ala Gly Gly  Thr Asp Val 
    2630                 2635                 2640             


Glu Pro  Lys Ser Ile Thr Val  His Arg Val Phe Ser  Gln Gly Ala 
    2645                 2650                 2655             


Ala Ser  Gln Glu Gly Thr Met  Asn Arg Gly Asp Phe  Leu Leu Ser 
    2660                 2665                 2670             


Val Asn  Gly Ala Ser Leu Ala  Gly Leu Ala His Gly  Asn Val Leu 
    2675                 2680                 2685             


Lys Val  Leu His Gln Ala Gln  Leu His Lys Asp Ala  Leu Val Val 
    2690                 2695                 2700             


Ile Lys  Lys Gly Met Asp Gln  Pro Arg Pro Ser Ala  Arg Gln Glu 
    2705                 2710                 2715             


Pro Pro  Thr Ala Asn Gly Lys  Gly Leu Leu Ser Arg  Lys Thr Ile 
    2720                 2725                 2730             


Pro Leu  Glu Pro Gly Ile Gly  Arg Ser Val Ala Val  His Asp Ala 
    2735                 2740                 2745             


Leu Cys  Val Glu Val Leu Lys  Thr Ser Ala Gly Leu  Gly Leu Ser 
    2750                 2755                 2760             


Leu Asp  Gly Gly Lys Ser Ser  Val Thr Gly Asp Gly  Pro Leu Val 
    2765                 2770                 2775             


Ile Lys  Arg Val Tyr Lys Gly  Gly Ala Ala Glu Gln  Ala Gly Ile 
    2780                 2785                 2790             


Ile Glu  Ala Gly Asp Glu Ile  Leu Ala Ile Asn Gly  Lys Pro Leu 
    2795                 2800                 2805             


Val Gly  Leu Met His Phe Asp  Ala Trp Asn Ile Met  Lys Ser Val 
    2810                 2815                 2820             


Pro Glu  Gly Pro Val Gln Leu  Leu Ile Arg Lys His  Arg Asn Ser 
    2825                 2830                 2835             


Ser 
    


<210>  163
<211>  5925
<212>  DNA
<213>  Homo sapiens

<400>  163
gcgctgcccg cctcgtcccc acccccccaa cccccgcgcc cgccctcgga cagtccctgc     60

tcgcccgcgc gctgcagccc catctcctag cggcagccca ggcgcggagg gagcgagtcc    120

gccccgaggt aggtccagga cgggcgcaca gcagcagccg aggctggccg ggagagggag    180

gaagaggatg gcagggccac gccccagccc atgggccagg ctgctcctgg cagccttgat    240

cagcgtcagc ctctctggga ccttggcaaa ccgctgcaag aaggccccag tgaagagctg    300

cacggagtgt gtccgtgtgg ataaggactg cgcctactgc acagacgaga tgttcaggga    360

ccggcgctgc aacacccagg cggagctgct ggccgcgggc tgccagcggg agagcatcgt    420

ggtcatggag agcagcttcc aaatcacaga ggagacccag attgacacca ccctgcggcg    480

cagccagatg tccccccaag gcctgcgggt ccgtctgcgg cccggtgagg agcggcattt    540

tgagctggag gtgtttgagc cactggagag ccccgtggac ctgtacatcc tcatggactt    600

ctccaactcc atgtccgatg atctggacaa cctcaagaag atggggcaga acctggctcg    660

ggtcctgagc cagctcacca gcgactacac tattggattt ggcaagtttg tggacaaagt    720

cagcgtcccg cagacggaca tgaggcctga gaagctgaag gagccctggc ccaacagtga    780

cccccccttc tccttcaaga acgtcatcag cctgacagaa gatgtggatg agttccggaa    840

taaactgcag ggagagcgga tctcaggcaa cctggatgct cctgagggcg gcttcgatgc    900

catcctgcag acagctgtgt gcacgaggga cattggctgg cgcccggaca gcacccacct    960

gctggtcttc tccaccgagt cagccttcca ctatgaggct gatggcgcca acgtgctggc   1020

tggcatcatg agccgcaacg atgaacggtg ccacctggac accacgggca cctacaccca   1080

gtacaggaca caggactacc cgtcggtgcc caccctggtg cgcctgctcg ccaagcacaa   1140

catcatcccc atctttgctg tcaccaacta ctcctatagc tactacgaga agcttcacac   1200

ctatttccct gtctcctcac tgggggtgct gcaggaggac tcgtccaaca tcgtggagct   1260

gctggaggag gccttcaatc ggatccgctc caacctggac atccgggccc tagacagccc   1320

ccgaggcctt cggacagagg tcacctccaa gatgttccag aagacgagga ctgggtcctt   1380

tcacatccgg cggggggaag tgggtatata ccaggtgcag ctgcgggccc ttgagcacgt   1440

ggatgggacg cacgtgtgcc agctgccgga ggaccagaag ggcaacatcc atctgaaacc   1500

ttccttctcc gacggcctca agatggacgc gggcatcatc tgtgatgtgt gcacctgcga   1560

gctgcaaaaa gaggtgcggt cagctcgctg cagcttcaac ggagacttcg tgtgcggaca   1620

gtgtgtgtgc agcgagggct ggagtggcca gacctgcaac tgctccaccg gctctctgag   1680

tgacattcag ccctgcctgc gggagggcga ggacaagccg tgctccggcc gtggggagtg   1740

ccagtgcggg cactgtgtgt gctacggcga aggccgctac gagggtcagt tctgcgagta   1800

tgacaacttc cagtgtcccc gcacttccgg gttcctctgc aatgaccgag gacgctgctc   1860

catgggccag tgtgtgtgtg agcctggttg gacaggccca agctgtgact gtcccctcag   1920

caatgccacc tgcatcgaca gcaatggggg catctgtaat ggacgtggcc actgtgagtg   1980

tggccgctgc cactgccacc agcagtcgct ctacacggac accatctgcg agatcaacta   2040

ctcggcgatc cacccgggcc tctgcgagga cctacgctcc tgcgtgcagt gccaggcgtg   2100

gggcaccggc gagaagaagg ggcgcacgtg tgaggaatgc aacttcaagg tcaagatggt   2160

ggacgagctt aagagagccg aggaggtggt ggtgcgctgc tccttccggg acgaggatga   2220

cgactgcacc tacagctaca ccatggaagg tgacggcgcc cctgggccca acagcactgt   2280

cctggtgcac aagaagaagg actgccctcc gggctccttc tggtggctca tccccctgct   2340

cctcctcctc ctgccgctcc tggccctgct actgctgcta tgctggaagt actgtgcctg   2400

ctgcaaggcc tgcctggcac ttctcccgtg ctgcaaccga ggtcacatgg tgggctttaa   2460

ggaagaccac tacatgctgc gggagaacct gatggcctct gaccacttgg acacgcccat   2520

gctgcgcagc gggaacctca agggccgtga cgtggtccgc tggaaggtca ccaacaacat   2580

gcagcggcct ggctttgcca ctcatgccgc cagcatcaac cccacagagc tggtgcccta   2640

cgggctgtcc ttgcgcctgg cccgcctttg caccgagaac ctgctgaagc ctgacactcg   2700

ggagtgcgcc cagctgcgcc aggaggtgga ggagaacctg aacgaggtct acaggcagat   2760

ctccggtgta cacaagctcc agcagaccaa gttccggcag cagcccaatg ccgggaaaaa   2820

gcaagaccac accattgtgg acacagtgct gatggcgccc cgctcggcca agccggccct   2880

gctgaagctt acagagaagc aggtggaaca gagggccttc cacgacctca aggtggcccc   2940

cggctactac accctcactg cagaccagga cgcccggggc atggtggagt tccaggaggg   3000

cgtggagctg gtggacgtac gggtgcccct ctttatccgg cctgaggatg acgacgagaa   3060

gcagctgctg gtggaggcca tcgacgtgcc cgcaggcact gccaccctcg gccgccgcct   3120

ggtaaacatc accatcatca aggagcaagc cagagacgtg gtgtcctttg agcagcctga   3180

gttctcggtc agccgcgggg accaggtggc ccgcatccct gtcatccggc gtgtcctgga   3240

cggcgggaag tcccaggtct cctaccgcac acaggatggc accgcgcagg gcaaccggga   3300

ctacatcccc gtggagggtg agctgctgtt ccagcctggg gaggcctgga aagagctgca   3360

ggtgaagctc ctggagctgc aagaagttga ctccctcctg cggggccgcc aggtccgccg   3420

tttccacgtc cagctcagca accctaagtt tggggcccac ctgggccagc cccactccac   3480

caccatcatc atcagggacc cagatgaact ggaccggagc ttcacgagtc agatgttgtc   3540

atcacagcca ccccctcacg gcgacctggg cgccccgcag aaccccaatg ctaaggccgc   3600

tgggtccagg aagatccatt tcaactggct gcccccttct ggcaagccaa tggggtacag   3660

ggtaaagtac tggattcagg gtgactccga atccgaagcc cacctgctcg acagcaaggt   3720

gccctcagtg gagctcacca acctgtaccc gtattgcgac tatgagatga aggtgtgcgc   3780

ctacggggct cagggcgagg gaccctacag ctccctggtg tcctgccgca cccaccagga   3840

agtgcccagc gagccagggc gtctggcctt caatgtcgtc tcctccacgg tgacccagct   3900

gagctgggct gagccggctg agaccaacgg tgagatcaca gcctacgagg tctgctatgg   3960

cctggtcaac gatgacaacc gacctattgg gcccatgaag aaagtgctgg ttgacaaccc   4020

taagaaccgg atgctgctta ttgagaacct tcgggagtcc cagccctacc gctacacggt   4080

gaaggcgcgc aacggggccg gctgggggcc tgagcgggag gccatcatca acctggccac   4140

ccagcccaag aggcccatgt ccatccccat catccctgac atccctatcg tggacgccca   4200

gagcggggag gactacgaca gcttccttat gtacagcgat gacgttctac gctctccatc   4260

gggcagccag aggcccagcg tctccgatga cactggctgc ggctggaagt tcgagcccct   4320

gctgggggag gagctggacc tgcggcgcgt cacgtggcgg ctgcccccgg agctcatccc   4380

gcgcctgtcg gccagcagcg ggcgctcctc cgacgccgag gcgccccacg ggcccccgga   4440

cgacggcggc gcgggcggga agggcggcag cctgccccgc agtgcgacac ccgggccccc   4500

cggagagcac ctggtgaatg gccggatgga ctttgccttc ccgggcagca ccaactccct   4560

gcacaggatg accacgacca gtgctgctgc ctatggcacc cacctgagcc cacacgtgcc   4620

ccaccgcgtg ctaagcacat cctccaccct cacacgggac tacaactcac tgacccgctc   4680

agaacactca cactcgacca cactgcccag ggactactcc accctcacct ccgtctcctc   4740

ccacgactct cgcctgactg ctggtgtgcc cgacacgccc acccgcctgg tgttctctgc   4800

cctggggccc acatctctca gagtgagctg gcaggagccg cggtgcgagc ggccgctgca   4860

gggctacagt gtggagtacc agctgctgaa cggcggtgag ctgcatcggc tcaacatccc   4920

caaccctgcc cagacctcgg tggtggtgga agacctcctg cccaaccact cctacgtgtt   4980

ccgcgtgcgg gcccagagcc aggaaggctg gggccgagag cgtgagggtg tcatcaccat   5040

tgaatcccag gtgcacccgc agagcccact gtgtcccctg ccaggctccg ccttcacttt   5100

gagcactccc agtgccccag gcccgctggt gttcactgcc ctgagcccag actcgctgca   5160

gctgagctgg gagcggccac ggaggcccaa tggggatatc gtcggctacc tggtgacctg   5220

tgagatggcc caaggaggag ggccagccac cgcattccgg gtggatggag acagccccga   5280

gagccggctg accgtgccgg gcctcagcga gaacgtgccc tacaagttca aggtgcaggc   5340

caggaccact gagggcttcg ggccagagcg cgagggcatc atcaccatag agtcccagga   5400

tggaggaccc ttcccgcagc tgggcagccg tgccgggctc ttccagcacc cgctgcaaag   5460

cgagtacagc agcatcacca ccacccacac cagcgccacc gagcccttcc tagtggatgg   5520

gctgaccctg ggggcccagc acctggaggc aggcggctcc ctcacccggc atgtgaccca   5580

ggagtttgtg agccggacac tgaccaccag cggaaccctt agcacccaca tggaccaaca   5640

gttcttccaa acttgaccgc accctgcccc acccccgcca cgtcccacta ggcgtcctcc   5700

cgactcctct cccggagcct cctcagctac tccatccttg cacccctggg ggcccagccc   5760

acccgcatgc acagagcagg ggctaggtgt ctcctgggag gcatgaaggg ggcaaggtcc   5820

gtcctctgtg ggcccaaacc tatttgtaac caaagagctg ggagcagcac aaggacccag   5880

cctttgttct gcacttaata aatggttttg ctactgctaa aaaaa                   5925


<210>  164
<211>  1822
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                  25                  30          


Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                  40                  45              


Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                  55                  60                  


Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                  70                  75                  80  


Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                  90                  95      


Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                 105                 110         


Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                 120                 125             


Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                 135                 140                 


Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                 150                 155                 160 


Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                 170                 175     


Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                 185                 190         


Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                 200                 205             


Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                 215                 220                 


Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                 230                 235                 240 


Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                 250                 255     


His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                 265                 270         


Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                 280                 285             


His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                 295                 300                 


Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                 310                 315                 320 


Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                 330                 335     


His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                 345                 350         


Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                 360                 365             


Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                 375                 380                 


Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                 390                 395                 400 


Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                 410                 415     


His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                 425                 430         


Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                 440                 445             


Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                 455                 460                 


Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                 470                 475                 480 


Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                 490                 495     


Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                 505                 510         


Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                 520                 525             


Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                 535                 540                 


Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                 550                 555                 560 


Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                 570                 575     


Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                 585                 590         


Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                 600                 605             


Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                 615                 620                 


Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                 630                 635                 640 


Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                 650                 655     


Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                 665                 670         


Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                 680                 685             


Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                 695                 700                 


Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                 730                 735     


Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                 745                 750         


His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                 760                 765             


Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                 775                 780                 


Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                 790                 795                 800 


Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                 810                 815     


Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                 825                 830         


Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                 840                 845             


Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                 855                 860                 


Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                 870                 875                 880 


His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                 890                 895     


Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                 905                 910         


Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                 920                 925             


Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                 935                 940                 


Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                 950                 955                 960 


Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                 970                 975     


Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                 985                 990         


Ser Phe Glu Gln Pro Glu Phe Ser  Val Ser Arg Gly Asp  Gln Val Ala 
        995                 1000                 1005             


Arg Ile  Pro Val Ile Arg Arg  Val Leu Asp Gly Gly  Lys Ser Gln 
    1010                 1015                 1020             


Val Ser  Tyr Arg Thr Gln Asp  Gly Thr Ala Gln Gly  Asn Arg Asp 
    1025                 1030                 1035             


Tyr Ile  Pro Val Glu Gly Glu  Leu Leu Phe Gln Pro  Gly Glu Ala 
    1040                 1045                 1050             


Trp Lys  Glu Leu Gln Val Lys  Leu Leu Glu Leu Gln  Glu Val Asp 
    1055                 1060                 1065             


Ser Leu  Leu Arg Gly Arg Gln  Val Arg Arg Phe His  Val Gln Leu 
    1070                 1075                 1080             


Ser Asn  Pro Lys Phe Gly Ala  His Leu Gly Gln Pro  His Ser Thr 
    1085                 1090                 1095             


Thr Ile  Ile Ile Arg Asp Pro  Asp Glu Leu Asp Arg  Ser Phe Thr 
    1100                 1105                 1110             


Ser Gln  Met Leu Ser Ser Gln  Pro Pro Pro His Gly  Asp Leu Gly 
    1115                 1120                 1125             


Ala Pro  Gln Asn Pro Asn Ala  Lys Ala Ala Gly Ser  Arg Lys Ile 
    1130                 1135                 1140             


His Phe  Asn Trp Leu Pro Pro  Ser Gly Lys Pro Met  Gly Tyr Arg 
    1145                 1150                 1155             


Val Lys  Tyr Trp Ile Gln Gly  Asp Ser Glu Ser Glu  Ala His Leu 
    1160                 1165                 1170             


Leu Asp  Ser Lys Val Pro Ser  Val Glu Leu Thr Asn  Leu Tyr Pro 
    1175                 1180                 1185             


Tyr Cys  Asp Tyr Glu Met Lys  Val Cys Ala Tyr Gly  Ala Gln Gly 
    1190                 1195                 1200             


Glu Gly  Pro Tyr Ser Ser Leu  Val Ser Cys Arg Thr  His Gln Glu 
    1205                 1210                 1215             


Val Pro  Ser Glu Pro Gly Arg  Leu Ala Phe Asn Val  Val Ser Ser 
    1220                 1225                 1230             


Thr Val  Thr Gln Leu Ser Trp  Ala Glu Pro Ala Glu  Thr Asn Gly 
    1235                 1240                 1245             


Glu Ile  Thr Ala Tyr Glu Val  Cys Tyr Gly Leu Val  Asn Asp Asp 
    1250                 1255                 1260             


Asn Arg  Pro Ile Gly Pro Met  Lys Lys Val Leu Val  Asp Asn Pro 
    1265                 1270                 1275             


Lys Asn  Arg Met Leu Leu Ile  Glu Asn Leu Arg Glu  Ser Gln Pro 
    1280                 1285                 1290             


Tyr Arg  Tyr Thr Val Lys Ala  Arg Asn Gly Ala Gly  Trp Gly Pro 
    1295                 1300                 1305             


Glu Arg  Glu Ala Ile Ile Asn  Leu Ala Thr Gln Pro  Lys Arg Pro 
    1310                 1315                 1320             


Met Ser  Ile Pro Ile Ile Pro  Asp Ile Pro Ile Val  Asp Ala Gln 
    1325                 1330                 1335             


Ser Gly  Glu Asp Tyr Asp Ser  Phe Leu Met Tyr Ser  Asp Asp Val 
    1340                 1345                 1350             


Leu Arg  Ser Pro Ser Gly Ser  Gln Arg Pro Ser Val  Ser Asp Asp 
    1355                 1360                 1365             


Thr Gly  Cys Gly Trp Lys Phe  Glu Pro Leu Leu Gly  Glu Glu Leu 
    1370                 1375                 1380             


Asp Leu  Arg Arg Val Thr Trp  Arg Leu Pro Pro Glu  Leu Ile Pro 
    1385                 1390                 1395             


Arg Leu  Ser Ala Ser Ser Gly  Arg Ser Ser Asp Ala  Glu Ala Pro 
    1400                 1405                 1410             


His Gly  Pro Pro Asp Asp Gly  Gly Ala Gly Gly Lys  Gly Gly Ser 
    1415                 1420                 1425             


Leu Pro  Arg Ser Ala Thr Pro  Gly Pro Pro Gly Glu  His Leu Val 
    1430                 1435                 1440             


Asn Gly  Arg Met Asp Phe Ala  Phe Pro Gly Ser Thr  Asn Ser Leu 
    1445                 1450                 1455             


His Arg  Met Thr Thr Thr Ser  Ala Ala Ala Tyr Gly  Thr His Leu 
    1460                 1465                 1470             


Ser Pro  His Val Pro His Arg  Val Leu Ser Thr Ser  Ser Thr Leu 
    1475                 1480                 1485             


Thr Arg  Asp Tyr Asn Ser Leu  Thr Arg Ser Glu His  Ser His Ser 
    1490                 1495                 1500             


Thr Thr  Leu Pro Arg Asp Tyr  Ser Thr Leu Thr Ser  Val Ser Ser 
    1505                 1510                 1515             


His Asp  Ser Arg Leu Thr Ala  Gly Val Pro Asp Thr  Pro Thr Arg 
    1520                 1525                 1530             


Leu Val  Phe Ser Ala Leu Gly  Pro Thr Ser Leu Arg  Val Ser Trp 
    1535                 1540                 1545             


Gln Glu  Pro Arg Cys Glu Arg  Pro Leu Gln Gly Tyr  Ser Val Glu 
    1550                 1555                 1560             


Tyr Gln  Leu Leu Asn Gly Gly  Glu Leu His Arg Leu  Asn Ile Pro 
    1565                 1570                 1575             


Asn Pro  Ala Gln Thr Ser Val  Val Val Glu Asp Leu  Leu Pro Asn 
    1580                 1585                 1590             


His Ser  Tyr Val Phe Arg Val  Arg Ala Gln Ser Gln  Glu Gly Trp 
    1595                 1600                 1605             


Gly Arg  Glu Arg Glu Gly Val  Ile Thr Ile Glu Ser  Gln Val His 
    1610                 1615                 1620             


Pro Gln  Ser Pro Leu Cys Pro  Leu Pro Gly Ser Ala  Phe Thr Leu 
    1625                 1630                 1635             


Ser Thr  Pro Ser Ala Pro Gly  Pro Leu Val Phe Thr  Ala Leu Ser 
    1640                 1645                 1650             


Pro Asp  Ser Leu Gln Leu Ser  Trp Glu Arg Pro Arg  Arg Pro Asn 
    1655                 1660                 1665             


Gly Asp  Ile Val Gly Tyr Leu  Val Thr Cys Glu Met  Ala Gln Gly 
    1670                 1675                 1680             


Gly Gly  Pro Ala Thr Ala Phe  Arg Val Asp Gly Asp  Ser Pro Glu 
    1685                 1690                 1695             


Ser Arg  Leu Thr Val Pro Gly  Leu Ser Glu Asn Val  Pro Tyr Lys 
    1700                 1705                 1710             


Phe Lys  Val Gln Ala Arg Thr  Thr Glu Gly Phe Gly  Pro Glu Arg 
    1715                 1720                 1725             


Glu Gly  Ile Ile Thr Ile Glu  Ser Gln Asp Gly Gly  Pro Phe Pro 
    1730                 1735                 1740             


Gln Leu  Gly Ser Arg Ala Gly  Leu Phe Gln His Pro  Leu Gln Ser 
    1745                 1750                 1755             


Glu Tyr  Ser Ser Ile Thr Thr  Thr His Thr Ser Ala  Thr Glu Pro 
    1760                 1765                 1770             


Phe Leu  Val Asp Gly Leu Thr  Leu Gly Ala Gln His  Leu Glu Ala 
    1775                 1780                 1785             


Gly Gly  Ser Leu Thr Arg His  Val Thr Gln Glu Phe  Val Ser Arg 
    1790                 1795                 1800             


Thr Leu  Thr Thr Ser Gly Thr  Leu Ser Thr His Met  Asp Gln Gln 
    1805                 1810                 1815             


Phe Phe  Gln Thr 
    1820         


<210>  165
<211>  5913
<212>  DNA
<213>  Homo sapiens

<400>  165
gtggacgcag cgggctttgg aaaggcccca agttaatgag gcgtgcgccg gctgccgagc     60

gcctcttgga gctgggcttt cccccgcggt gcgggcgcca ggagccgcct tttccgctgg    120

gtgtcactcg ggggtgggga agatggccca ttcaaaagcg ccgcgagggg gcccggccag    180

tgcccttcag tgagcgctcg caagaggacg gcagaggccc ggcagctcgg agctccggga    240

ccttgtggcg catcaggacg cggctgtccc tctgccggga cccagagccg ccgccgccgc    300

tctgcctcct gcgtgttagc ctcctctgcg cgctccgggc aggcggccgt gggagccgct    360

ggggcgagga cggcgcgagg ctgctgctgc tgcccccggc ccgcgcggct ggaaacggag    420

aggccgagcc aagcggcggc ccctcttatg ctgggaggat gctggagagt agcggctgca    480

aagcgctgaa ggagggcgtg ctggagaagc gcagcgacgg gttgttgcag ctctggaaga    540

aaaagtgttg catcctcacc gaggaagggc tgctgcttat cccgcccaag cagctgcaac    600

accagcagca gcagcagcaa cagcagcagc agcagcagca acaacagccc gggcaggggc    660

cggccgagcc gtcccaaccc agtggccccg ctgtcgccag cctcgagccg ccggtcaagc    720

tcaaggaact gcacttctcc aacatgaaga ccgtggactg tgtggagcgc aagggcaagt    780

acatgtactt cactgtggtg atggcagagg gcaaggagat cgactttcgg tgcccgcaag    840

accagggctg gaacgccgag atcacgctgc agatggtgca gtacaagaat cgtcaggcca    900

tcctggcggt caaatccacg cggcagaagc agcagcacct ggtccagcag cagcccccct    960

cgcagccgca gccgcagccg cagctccagc cccaacccca gcctcagcct cagccgcaac   1020

cccagcccca atcacaaccc cagcctcagc cccaacccaa gcctcagccc cagcagctcc   1080

acccgtatcc gcatccacat ccacatccac actctcatcc tcactcgcac ccacaccctc   1140

acccgcaccc gcatccgcac caaataccgc acccacaccc acagccgcac tcgcagccgc   1200

acgggcaccg gcttctccgc agcacctcca actctgcctg aaaggggcag ctcccgggca   1260

agacaaggtt ttgaggactt gaggaagtgg gacgagcaca tttctattgt cttcacttgg   1320

atcaaaagca aaacagtctc tccgccccgc accagatcaa gtagtttgga catcacccta   1380

ctgaaaactt gcgattcttc ttagttttct gcatactttt catcacgatg caggaaacga   1440

tttcgagtca agaagacttt tatttatgaa cctttgaaag gatcgtcttg tatggtgaat   1500

tttctaggag cgatgatgta ctgtaatttt attttaatgt attttgattt atgattattt   1560

attagttttt ttttaaatgc ttgttctaag acatttctga atgtagacca ttttccaaaa   1620

aggaaacttt attttcaaaa acctaatccg tagtaattcc taatcttgga gaataaaaaa   1680

gggcggtgga ggggaaaaca ttaagaattt attcattatt tctcgagtac tttcagaaag   1740

tctgacactt tcattgttgt gccagctggt tgaaattaaa actctgatat tacttttttt   1800

gaggattttt atttttgttt ttgcttaaac atatagtttg tctagaagtt taaaaagcta   1860

aaagttaaaa atggtgtaat tatgaaaatc taacactcaa gatagtttct aaaaggaaat   1920

cagtagttaa ggatacctga tttcaaaata tttaaagcat aacctaactg atggtaggat   1980

gattgtatct tgaatatgtg gtagggccac atctattgta ggaaaacctt gcttttatca   2040

tctgtgtgta aagggcttaa taaggagaag aggccttttg actgatttgt gagtataaat   2100

gcatttgctg tttcatttca aaaatgttgt ggaggaaaag agtacattta acttgtataa   2160

gagaatattt gtactcctgt ccaggctgca ggacctttct tcgagagctt tgcacacttg   2220

acttgaacca cattttctga tccctttact ttgttttaga agcacactga aaaatctcgt   2280

tgtttaaagt acaatttgta aatatttcaa aggtctagga gtcataactt ttgttttcat   2340

actgaaaatg atgttgatca gagaaaccaa ctgttttgct tttcattgct ctgtgagaaa   2400

tttgaggatt ctgttttgct gttaggtaag ctaaactcag aaattgaaaa ggaaaagact   2460

ggataaacac aggattttca gtaagaaaac aaccccagtc ttgtcttaga agccacttgt   2520

tgaggagtct gttgggggaa aaaagaggat atgcttttaa aggtagaaca aaccttcttc   2580

tgtgttaaat caaaaggatg ttcaaaatcc accaggacag atgctacttg ggtttaaatg   2640

gagccataga tgatacaaag tcctcttggg gctgaaaatc acttcctatt tgcatggctt   2700

tactaactgg tttctgtttt ccattatctt tttcacagaa agtcttggtc agtatttttc   2760

cagcatttaa attgaaacgg tcagtattag accactgcta ggttatgtag tcaagaaata   2820

aaaatagaat tacatgctac agatgtcttt attctccttc catctagaaa ggagttccaa   2880

ggtcaaatta ctttttagtg caatagttaa atgacatttt gagatcataa ctcatatcca   2940

aaaagttgca gggaaaatta aaatagcttt cccctattaa gctaatggca aacaaaactt   3000

aagtggaccc ccacttccag tggttgttta ggttgcagtt gtgaaaatat gctgccaaca   3060

tttaaaaact tgtttcatat gtatatatgt atacacatat atgaatatgt atgtatatat   3120

acatatatga gaacatgtgt gtacacatat atgaatatgt atatatgtgt atgtatgtat   3180

atatgtatat gaaatgagag ccacatctaa agatttctta aatcaagttt ggttcagctt   3240

ccttagaact gtggctgtac tttttgagga gtacctcata gtactatatt tttaatgcat   3300

gcaaatcata atagctccaa atgaaccaca gttttttccc aatggaggat ttttttttaa   3360

ttcttgtact aaaaaaaaaa aatccatacc aaatattttt acaaattaag attgatgtag   3420

gttttaaaaa aggcatttgt atgttgttag cttacatatg gggctaggta atttcattgc   3480

ttaaaaagat gcgcctaggc tccctcttgg tggctggatt tctttttctt cgcccgtggt   3540

ggccatggtt cttaataggg ccaccggaat catggtttct tttttttttt ttttttttga   3600

gatggagtct cgccctgtga cccaggctgg agtgcagtgg cacgatctcg gctcactgca   3660

acctctgcct cctgggttca cgccattctc ctgtctcagc ctcctgagta gctgggacta   3720

caggtgaatg ccaccacgcc cggctgattt ttgtattttt agtagagatg gggtttcacc   3780

atagtggtca ggctgttctc gaactcctga cctcaggtga tccacctgcc ttggcctccc   3840

aaagtgctag gattacaggt gtgagccacc acacccggcc ccagaataat ggtttcttga   3900

ctttctgtag cccttgttcc ttagtctgct gtgatattta tgttgacctt tatcattttc   3960

tattctgaac ccctcttagc atttaatgtg aaatctaaga aattagaagt agaatggctt   4020

ttattgtttt gacacctttg aaattattat taataatttt tccagagcaa aaaagcaaac   4080

acgctcaata agactaaaca aaacaaaata taaatgtaca tcatttaatg tcccagtggc   4140

tctattctac ctgtaagaaa atgatacaaa accacctaag atattttgaa gcctgacaaa   4200

tcagcttcat ggaaaaaggt aaaaaatgca tttttcaacc gaaagggcag atccaataga   4260

agacccgctc cttaaataaa cataaaatgt aaaaagttgg aaaattaaga gtaatgttcc   4320

atctggaaac tgaacttttg tccttgaact tgtgttggca ccaagcctca tacacagtga   4380

gctcaataac tgttgggaca aaggaaggaa ggacaaaatg tgtaacttcc cagcatctgg   4440

gagatgctgt ctcttgcctc actgagtgtt ccttttcttt gctctcatgt cattccctga   4500

gaacaatgaa ttctgggaca ggctaaacat catgatgaag tttcttaaac agactttctt   4560

agtggaaatc catttagatc tgggtgtgct ctatggggag tgctgacgtc aaagagcaaa   4620

tgtctataag gggccctttt aaaatgaaca ttttcctcat tgagcaagct gggattctct   4680

aatgtagaaa tcaagccatc tttataattt cacttcagat gtttatgttt ttgttttttt   4740

tgtctccaat gatggtaaaa ataaaaacta cgcattactt aaaggagttt ccctcacatg   4800

taaacactgt taggaagtct ggattaagtt gaaagtcctg ttttaacttt ttttctctca   4860

tataccaaac actctgtatt tctcttaaag aagcccttta agagaaagcc ctaattttat   4920

atctgacagt aaagtttgct gcaagtgtat gagttcaaac acatcccttg ttttctgtcc   4980

ctaggggaaa agtcatgtag ttttagcttg gctccagtgt taatattata ttcagtagca   5040

gccttagaag agtggtctaa gacttgaacc tggagcaatt ttatagcaca gaatcctacg   5100

aagataggac tgtgaacatt tgttttcttt ttcgtgtgtg tcaaactaac tggtttttgc   5160

tttaccaata aaatgtcctc ggcagagtaa attttaaacg tgaaaattat agatcttgat   5220

attgaatcca tcagtgattc aagagataca cctatttgcc taaaacaacc taagatgtat   5280

tggttatgga atcatgtgtt ggataggttc ttaagacctg tttcctcaaa tcttgacaca   5340

gttttcaagg gtggcttatt gacttgcacg gttgggcaga taatccagat ttacctaaga   5400

ttgggtaaaa aagtcatctg tgactttgct ggcagggcat ttgctaagtg gagtacagga   5460

tctaaaaggg ttttcttaga aagggcaata ttgtccaatg aagtaagcag aaggactctg   5520

ggttagaagc atctgcacaa aaactggtga gacctactct ccactgctct gcagctggat   5580

ggctgatggc aggctgagca gtggggaagc aggttttaac aacagggagt ccttccaggt   5640

cactgtatat tgagaagaaa cataaaacta ttgtctgtta cattccgagg tcagccttct   5700

tcttaacgtt ttataatatg caaatgccag cttctggaaa gcaagtatca tcatgtacca   5760

aatgctttat acaccatcac attcatgaat tttttagcat ggtcagaact tgtgtaaata   5820

tgtctcttag atgattttgg ggagatgtga tttatttttc atattttcaa aatgcatttc   5880

atttcaaata aagttatcta ttgagacaac cga                                5913


<210>  166
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Arg Arg Ala Pro Ala Ala Glu Arg Leu Leu Glu Leu Gly Phe Pro 
1               5                   10                  15      


Pro Arg Cys Gly Arg Gln Glu Pro Pro Phe Pro Leu Gly Val Thr Arg 
            20                  25                  30          


Gly Trp Gly Arg Trp Pro Ile Gln Lys Arg Arg Glu Gly Ala Arg Pro 
        35                  40                  45              


Val Pro Phe Ser Glu Arg Ser Gln Glu Asp Gly Arg Gly Pro Ala Ala 
    50                  55                  60                  


Arg Ser Ser Gly Thr Leu Trp Arg Ile Arg Thr Arg Leu Ser Leu Cys 
65                  70                  75                  80  


Arg Asp Pro Glu Pro Pro Pro Pro Leu Cys Leu Leu Arg Val Ser Leu 
                85                  90                  95      


Leu Cys Ala Leu Arg Ala Gly Gly Arg Gly Ser Arg Trp Gly Glu Asp 
            100                 105                 110         


Gly Ala Arg Leu Leu Leu Leu Pro Pro Ala Arg Ala Ala Gly Asn Gly 
        115                 120                 125             


Glu Ala Glu Pro Ser Gly Gly Pro Ser Tyr Ala Gly Arg Met Leu Glu 
    130                 135                 140                 


Ser Ser Gly Cys Lys Ala Leu Lys Glu Gly Val Leu Glu Lys Arg Ser 
145                 150                 155                 160 


Asp Gly Leu Leu Gln Leu Trp Lys Lys Lys Cys Cys Ile Leu Thr Glu 
                165                 170                 175     


Glu Gly Leu Leu Leu Ile Pro Pro Lys Gln Leu Gln His Gln Gln Gln 
            180                 185                 190         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gly Gln Gly 
        195                 200                 205             


Pro Ala Glu Pro Ser Gln Pro Ser Gly Pro Ala Val Ala Ser Leu Glu 
    210                 215                 220                 


Pro Pro Val Lys Leu Lys Glu Leu His Phe Ser Asn Met Lys Thr Val 
225                 230                 235                 240 


Asp Cys Val Glu Arg Lys Gly Lys Tyr Met Tyr Phe Thr Val Val Met 
                245                 250                 255     


Ala Glu Gly Lys Glu Ile Asp Phe Arg Cys Pro Gln Asp Gln Gly Trp 
            260                 265                 270         


Asn Ala Glu Ile Thr Leu Gln Met Val Gln Tyr Lys Asn Arg Gln Ala 
        275                 280                 285             


Ile Leu Ala Val Lys Ser Thr Arg Gln Lys Gln Gln His Leu Val Gln 
    290                 295                 300                 


Gln Gln Pro Pro Ser Gln Pro Gln Pro Gln Pro Gln Leu Gln Pro Gln 
305                 310                 315                 320 


Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Ser Gln Pro Gln 
                325                 330                 335     


Pro Gln Pro Gln Pro Lys Pro Gln Pro Gln Gln Leu His Pro Tyr Pro 
            340                 345                 350         


His Pro His Pro His Pro His Ser His Pro His Ser His Pro His Pro 
        355                 360                 365             


His Pro His Pro His Pro His Gln Ile Pro His Pro His Pro Gln Pro 
    370                 375                 380                 


His Ser Gln Pro His Gly His Arg Leu Leu Arg Ser Thr Ser Asn Ser 
385                 390                 395                 400 


Ala 
    


<210>  167
<211>  836
<212>  DNA
<213>  Homo sapiens

<400>  167
ccagccttca gccggagaac cgtttactcg ctgctgtgcc catctatcag caggctccgg     60

gctgaagatt gcttctcttc tctcctccaa ggtctagtga cggagcccgc gcgcggcgcc    120

accatgcggc agaaggcggt atcgcttttc ttgtgctacc tgctgctctt cacttgcagt    180

ggggtggagg caggtaagaa aaagtgctcg gagagctcgg acagcggctc cgggttctgg    240

aaggccctga ccttcatggc cgtcggagga ggactcgcag tcgccgggct gcccgcgctg    300

ggcttcaccg gcgccggcat cgcggccaac tcggtggctg cctcgctgat gagctggtct    360

gcgatcctga atgggggcgg cgtgcccgcc ggggggctag tggccacgct gcagagcctc    420

ggggctggtg gcagcagcgt cgtcataggt aatattggtg ccctgatggg ctacgccacc    480

cacaagtatc tcgatagtga ggaggatgag gagtagccag cagctcccag aacctcttct    540

tccttcttgg cctaactctt ccagttagga tctagaactt tgcctttttt tttttttttt    600

tttttttgag atgggttctc actatattgt ccaggctaga gtgcagtggc tattcacaga    660

tgcgaacata gtacactgca gcctccaact cctagcctca agtgatcctc ctgtctcaac    720

ctcccaagta ggattacaag catgcgccga cgatgcccag aatccagaac tttgtctatc    780

actctcccca acaacctaga tgtgaaaaca gaataaactt cacccagaaa acactt        836


<210>  168
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Arg Gln Lys Ala Val Ser Leu Phe Leu Cys Tyr Leu Leu Leu Phe 
1               5                   10                  15      


Thr Cys Ser Gly Val Glu Ala Gly Lys Lys Lys Cys Ser Glu Ser Ser 
            20                  25                  30          


Asp Ser Gly Ser Gly Phe Trp Lys Ala Leu Thr Phe Met Ala Val Gly 
        35                  40                  45              


Gly Gly Leu Ala Val Ala Gly Leu Pro Ala Leu Gly Phe Thr Gly Ala 
    50                  55                  60                  


Gly Ile Ala Ala Asn Ser Val Ala Ala Ser Leu Met Ser Trp Ser Ala 
65                  70                  75                  80  


Ile Leu Asn Gly Gly Gly Val Pro Ala Gly Gly Leu Val Ala Thr Leu 
                85                  90                  95      


Gln Ser Leu Gly Ala Gly Gly Ser Ser Val Val Ile Gly Asn Ile Gly 
            100                 105                 110         


Ala Leu Met Gly Tyr Ala Thr His Lys Tyr Leu Asp Ser Glu Glu Asp 
        115                 120                 125             


Glu Glu 
    130 


<210>  169
<211>  4644
<212>  DNA
<213>  Homo sapiens

<400>  169
ggcggcggct ggaggagagc gcggtggaga gccgagcggg cgggcggcgg gtgcggagcg     60

ggcgagggag cgcgcgcggc cgccacaaag ctcgggcgcc gcggggctgc atgcggcgta    120

cctggcccgg cgcggcgact gctctccggg ctggcggggg ccggccgcga gccccggggg    180

ccccgaggcc gcagcttgcc tgcgcgctct gagccttcgc aactcgcgag caaagtttgg    240

tggaggcaac gccaagcctg agtcctttct tcctctcgtt ccccaaatcc gagggcagcc    300

cgcgggcgtc atgcccgcgc tcctccgcag cctggggtac gcgtgaagcc cgggaggctt    360

ggcgccggcg aagacccaag gaccactctt ctgcgtttgg agttgctccc cgcaaccccg    420

ggctcgtcgc tttctccatc ccgacccacg cggggcgcgg ggacaacaca ggtcgcggag    480

gagcgttgcc attcaagtga ctgcagcagc agcggcagcg cctcggttcc tgagcccacc    540

gcaggctgaa ggcattgcgc gtagtccatg cccgtagagg aagtgtgcag atgggattaa    600

cgtccacatg gagatatgga agaggaccgg ggattggtac cgtaaccatg gtcagctggg    660

gtcgtttcat ctgcctggtc gtggtcacca tggcaacctt gtccctggcc cggccctcct    720

tcagtttagt tgaggatacc acattagagc cagaagagcc accaaccaaa taccaaatct    780

ctcaaccaga agtgtacgtg gctgcgccag gggagtcgct agaggtgcgc tgcctgttga    840

aagatgccgc cgtgatcagt tggactaagg atggggtgca cttggggccc aacaatagga    900

cagtgcttat tggggagtac ttgcagataa agggcgccac gcctagagac tccggcctct    960

atgcttgtac tgccagtagg actgtagaca gtgaaacttg gtacttcatg gtgaatgtca   1020

cagatgccat ctcatccgga gatgatgagg atgacaccga tggtgcggaa gattttgtca   1080

gtgagaacag taacaacaag agagcaccat actggaccaa cacagaaaag atggaaaagc   1140

ggctccatgc tgtgcctgcg gccaacactg tcaagtttcg ctgcccagcc ggggggaacc   1200

caatgccaac catgcggtgg ctgaaaaacg ggaaggagtt taagcaggag catcgcattg   1260

gaggctacaa ggtacgaaac cagcactgga gcctcattat ggaaagtgtg gtcccatctg   1320

acaagggaaa ttatacctgt gtagtggaga atgaatacgg gtccatcaat cacacgtacc   1380

acctggatgt tgtggagcga tcgcctcacc ggcccatcct ccaagccgga ctgccggcaa   1440

atgcctccac agtggtcgga ggagacgtag agtttgtctg caaggtttac agtgatgccc   1500

agccccacat ccagtggatc aagcacgtgg aaaagaacgg cagtaaatac gggcccgacg   1560

ggctgcccta cctcaaggtt ctcaaggccg ccggtgttaa caccacggac aaagagattg   1620

aggttctcta tattcggaat gtaacttttg aggacgctgg ggaatatacg tgcttggcgg   1680

gtaattctat tgggatatcc tttcactctg catggttgac agttctgcca gcgcctggaa   1740

gagaaaagga gattacagct tccccagact acctggagat agccatttac tgcatagggg   1800

tcttcttaat cgcctgtatg gtggtaacag tcatcctgtg ccgaatgaag aacacgacca   1860

agaagccaga cttcagcagc cagccggctg tgcacaagct gaccaaacgt atccccctgc   1920

ggagacaggt aacagtttcg gctgagtcca gctcctccat gaactccaac accccgctgg   1980

tgaggataac aacacgcctc tcttcaacgg cagacacccc catgctggca ggggtctccg   2040

agtatgaact tccagaggac ccaaaatggg agtttccaag agataagctg acactgggca   2100

agcccctggg agaaggttgc tttgggcaag tggtcatggc ggaagcagtg ggaattgaca   2160

aagacaagcc caaggaggcg gtcaccgtgg ccgtgaagat gttgaaagat gatgccacag   2220

agaaagacct ttctgatctg gtgtcagaga tggagatgat gaagatgatt gggaaacaca   2280

agaatatcat aaatcttctt ggagcctgca cacaggatgg gcctctctat gtcatagttg   2340

agtatgcctc taaaggcaac ctccgagaat acctccgagc ccggaggcca cccgggatgg   2400

agtactccta tgacattaac cgtgttcctg aggagcagat gaccttcaag gacttggtgt   2460

catgcaccta ccagctggcc agaggcatgg agtacttggc ttcccaaaaa tgtattcatc   2520

gagatttagc agccagaaat gttttggtaa cagaaaacaa tgtgatgaaa atagcagact   2580

ttggactcgc cagagatatc aacaatatag actattacaa aaagaccacc aatgggcggc   2640

ttccagtcaa gtggatggct ccagaagccc tgtttgatag agtatacact catcagagtg   2700

atgtctggtc cttcggggtg ttaatgtggg agatcttcac tttagggggc tcgccctacc   2760

cagggattcc cgtggaggaa ctttttaagc tgctgaagga aggacacaga atggataagc   2820

cagccaactg caccaacgaa ctgtacatga tgatgaggga ctgttggcat gcagtgccct   2880

cccagagacc aacgttcaag cagttggtag aagacttgga tcgaattctc actctcacaa   2940

ccaatgagga atacttggac ctcagccaac ctctcgaaca gtattcacct agttaccctg   3000

acacaagaag ttcttgttct tcaggagatg attctgtttt ttctccagac cccatgcctt   3060

acgaaccatg ccttcctcag tatccacaca taaacggcag tgttaaaaca tgaatgactg   3120

tgtctgcctg tccccaaaca ggacagcact gggaacctag ctacactgag cagggagacc   3180

atgcctccca gagcttgttg tctccacttg tatatatgga tcagaggagt aaataattgg   3240

aaaagtaatc agcatatgtg taaagattta tacagttgaa aacttgtaat cttccccagg   3300

aggagaagaa ggtttctgga gcagtggact gccacaagcc accatgtaac ccctctcacc   3360

tgccgtgcgt actggctgtg gaccagtagg actcaaggtg gacgtgcgtt ctgccttcct   3420

tgttaatttt gtaataattg gagaagattt atgtcagcac acacttacag agcacaaatg   3480

cagtatatag gtgctggatg tatgtaaata tattcaaatt atgtataaat atatattata   3540

tatttacaag gagttatttt ttgtattgat tttaaatgga tgtcccaatg cacctagaaa   3600

attggtctct ctttttttaa tagctatttg ctaaatgctg ttcttacaca taatttctta   3660

attttcaccg agcagaggtg gaaaaatact tttgctttca gggaaaatgg tataacgtta   3720

atttattaat aaattggtaa tatacaaaac aattaatcat ttatagtttt ttttgtaatt   3780

taagtggcat ttctatgcag gcagcacagc agactagtta atctattgct tggacttaac   3840

tagttatcag atcctttgaa aagagaatat ttacaatata tgactaattt ggggaaaatg   3900

aagttttgat ttatttgtgt ttaaatgctg ctgtcagacg attgttctta gacctcctaa   3960

atgccccata ttaaaagaac tcattcatag gaaggtgttt cattttggtg tgcaaccctg   4020

tcattacgtc aacgcaacgt ctaactggac ttcccaagat aaatggtacc agcgtcctct   4080

taaaagatgc cttaatccat tccttgagga cagaccttag ttgaaatgat agcagaatgt   4140

gcttctctct ggcagctggc cttctgcttc tgagttgcac attaatcaga ttagcctgta   4200

ttctcttcag tgaattttga taatggcttc cagactcttt ggcgttggag acgcctgtta   4260

ggatcttcaa gtcccatcat agaaaattga aacacagagt tgttctgctg atagttttgg   4320

ggatacgtcc atctttttaa gggattgctt tcatctaatt ctggcaggac ctcaccaaaa   4380

gatccagcct catacctaca tcagacaaaa tatcgccgtt gttccttctg tactaaagta   4440

ttgtgttttg ctttggaaac acccactcac tttgcaatag ccgtgcaaga tgaatgcaga   4500

ttacactgat cttatgtgtt acaaaattgg agaaagtatt taataaaacc tgttaatttt   4560

tatactgaca ataaaaatgt ttctacagat attaatgtta acaagacaaa ataaatgtca   4620

cgcaacttaa aaaaaaaaaa aaaa                                          4644


<210>  170
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210>  171
<211>  6256
<212>  DNA
<213>  Homo sapiens

<400>  171
cgcgccgccg ctcgctcacc tgcgctcccg cccgcccctc ggtgcgcgcc cggcccgcca     60

gccgccgccg cccgcacccc gagcgccacc atgaactcgc tcttcaggaa gagaaacaaa    120

ggcaaataca gccccactgt gcagacccgg agcatctcta acaaggagct ctcggagctg    180

atcgagcagc tgcagaagaa tgccgaccag gtggagaaga acatcgtgga cacagaggcc    240

aagatgcaga gtgacctggc tcggctgcag gagggtcggc agcctgagca ccgggacgtg    300

accctgcaga aggtgttgga ctctgagaag ctgctctatg tgctagaggc ggatgcggcc    360

attgccaagc acatgaagca cccacagggg gacatgatcg ccgaggatat ccgccagctg    420

aaggagcgtg tgaccaacct gcgcgggaaa cacaagcaga tctacaggct ggcggtgaag    480

gaagtggatc cacaggtcaa ctgggcggca ctggtggagg agaagctgga caagctgaac    540

aaccagagct ttgggactga cctgccgctg gtggaccacc aagtggagga gcataacatc    600

ttccacaatg aggtcaaggc catcgggccc cacctggcca aggacgggga caaggagcag    660

aacagcgaac tccgggccaa gtaccagaaa ctgctggcag catcacaggc ccggcagcag    720

cacctgagtt cgctgcagga ctacatgcag cgctgcacca atgagctgta ctggctggac    780

cagcaggcca agggccgcat gcagtacgac tggagtgacc gcaacctcga ctaccccagc    840

cgccggcgcc agtatgagaa tttcatcaac cggaacctgg aggccaaaga ggagagaatc    900

aacaaactgc acagcgaggg cgaccagctg ctggcggccg agcaccccgg gaggaactcc    960

attgaggcgc acatggaggc tgtgcacgca gactggaagg agtacctgaa cctgctcatc   1020

tgcgaggaga gccacctcaa gtacatggag gactaccacc agtttcacga agacgtgaag   1080

gacgctcagg agctgctgcg caaggtggac tcggacctga accagaagta tggccctgac   1140

ttcaaggacc ggtaccagat tgagctgctg ctgcgggagc tggatgacca ggagaaggtg   1200

ctggacaagt atgaggacgt ggtgcagggg ctgcagaagc gaggccagca ggtggtgccc   1260

ctcaagtacc gccgggagac tccgctcaag cccatccccg tggaggcact ctgtgacttt   1320

gagggggagc agggcctgat ctcgcggggc tacagctaca ccctgcagaa gaacaacggg   1380

gagagctggg agctcatgga cagcgctggg aacaagctga ttgctccggc cgtgtgtttt   1440

gtgatccccc ccacagaccc tgaggccctg gctctggctg acagcctggg cagccagtac   1500

cggagcgtgc ggcagaaggc agctgggagc aaacgcacgc tgcagcagcg gtatgaggtg   1560

ctgaagaccg agaatcccgg agatgcctct gacctacagg ggcggcagct gctggctggc   1620

ttggacaagg tggccagcga cctggaccgg caggagaagg ccatcacagg gatcctgcgg   1680

ccaccactgg agcaaggccg ggctgtgcag gacagtgccg agcgggccaa ggacctcaag   1740

aacatcacca acgagctact gcggattgaa cctgagaaga cgcggagcac ggctgagggc   1800

gaagccttca tccaggccct cccaggcagt ggcaccacac ccctgctgag gacccgggtg   1860

gaggacacca accggaaata cgagcacctc ctgcagctgc tggacttggc ccaggagaag   1920

gttgatgtgg ccaaccgcct ggagaagagc ctgcagcaga gctgggagtt gctggccaca   1980

cacgagaacc atctgaatca ggatgacaca gtgcctgaga gcagccgtgt cctggacagc   2040

aaggggcagg agctggcggc catggcctgt gagttacagg cccagaagtc cctcctgggt   2100

gaggtggagc agaacttgca ggcggccaag cagtgctcga gcacactggc cagccgcttc   2160

caggagcact gtccggacct ggagcgccag gaggccgagg tgcacaagct gggccagcgt   2220

ttcaacaacc tgcgccagca ggtggaacgc agggcgcaga gcctacagag cgccaaggca   2280

gcctacgagc acttccaccg cggccatgac cacgtgctgc agttcctagt cagcatcccc   2340

agttacgagc cccaggagac agacagcctc agccagatgg agaccaagct gaagaaccag   2400

aagaacctgc tagatgagat agcaagtagg gagcaggaag tacagaagat ctgtgccaat   2460

tcccagcagt accagcaagc tgtaaaggac tatgagttag aagcagaaaa actaaggtct   2520

cttctcgact tggagaatgg aaggagcagc cacgtgagca agagagccag gctccaatct   2580

cctgccacca aagtgaagga agaggaagca gcacttgccg ccaagttcac tgaagtttat   2640

gccatcaaca gacagaggct gcagaatctg gagtttgctc tgaatctcct cagacagcag   2700

ccggaagtag aagtgaccca tgagaccctg caaaggaata ggccggactc tggagtggag   2760

gaggcgtgga agatcaggaa ggaactggat gaggagactg agcggaggcg gcagctggag   2820

aacgaggtca agagcaccca ggaagaaatc tggaccttga ggaatcaggg gcctcaggaa   2880

tcggtggtga ggaaggaggt gctcaagaag gtgccggatc ccgtgctgga ggagagcttc   2940

cagcagctgc agcggacgct ggcagaggag cagcacaaga accagctgct gcaggaggag   3000

ctggaggcac tgcagctgca gctgcgtgcc ctggagcagg agaccagaga cggggggcag   3060

gagtacgtgg tcaaggaggt cctgcgcatc gagcctgaca gggcccaggc ggatgaggtc   3120

ttgcagctgc gggaggagct ggaggcactg aggcggcaga agggcgcccg ggaggcagag   3180

gtgctcctcc tgcagcagcg tgtggccgcc ctggctgaag agaagagccg ggcgcaggag   3240

aaggtcacag agaaagaggt ggtgaaactg cagaatgacc cccagctgga ggcagagtac   3300

cagcagctgc aggaggacca ccagcgccag gaccagctca gggagaagca ggaggaggag   3360

ctgagcttcc tccaggacaa gctcaagagg ctagagaagg agcgggccat ggccgagggc   3420

aagatcaccg tcaaggaggt gctcaaggtg gagaaggacg cggccaccga gagggaggtc   3480

agcgatctca cccgccaata tgaggacgag gctgccaagg ctcgcgctag ccagagggag   3540

aagacggagc tgctccgaaa gatatgggcc ttggaggagg agaacgccaa agtggtggtg   3600

caggagaagg tgcgggagat cgtgcggcca gaccccaagg cggaaagtga agtggcgaac   3660

ctccgcctgg agcttgtgga gcaggagcga aagtaccggg gtgccgagga gcagctccgg   3720

agctaccaga gtgagctgga ggccctcagg aggcgaggcc cccaggtgga agtcaaagag   3780

gtgactaagg aagtcattaa gtacaagact gaccctgaga tggagaagga gcttcagcgg   3840

ctcagggagg agatcgtgga caagaccaga ctgatcgaaa ggtgtgattt agagatctac   3900

cagctgaaaa aggaaatcca ggccctgaaa gacaccaaac cccaggtcca gaccaaagag   3960

gtggtccagg agatcctcca attccaagaa gaccctcaaa ccaaggagga ggtggcgtct   4020

ctgagggcaa agctctcaga ggagcagaag aaacaagtgg atctggagag ggaaagagct   4080

tcccaggaag agcagatcgc ccggaaagag gaggagctct cgcgggtgaa ggaaagggtg   4140

gtgcagcagg aggtggtcag gtatgaggag gagccaggcc tgcgggccga ggcgagcgcc   4200

tttgccgaga gcatcgatgt ggagctgcgg cagattgaca agctgcgggc agagctgcgg   4260

cggctgcagc gccggcgcac cgagcttgag cggcagctgg aggagctaga gcgcgagcgg   4320

caggcccgca gggaggccga gcgcgaggta cagcggttgc agcagcggct ggcagcgctg   4380

gagcaggaag aagctgaggc ccgtgagaag gtaacccata cgcagaaggt ggtgctgcag   4440

caggacccgc agcaggcgcg agagcatgcc ctgctccgac tccagctgga agaagagcag   4500

caccggcggc agctcctgga gggggagctc gagaccctcc ggaggaaact ggctgcactg   4560

gagaaggcgg aggtcaagga gaaggtggtg ctctccgaga gtgtccaggt ggagaagggc   4620

gacaccgagc aagagatcca gaggctcaag agcagcctgg aggaggagag ccgcagcaag   4680

cgcgagctgg acgtcgaggt gagccggctg gaagccaggc tttcggagct ggaattccat   4740

aactccaagt catccaagga actagacttt ctgagggaag agaaccacaa attacagctg   4800

gagaggcaaa acctgcagct ggagacccga aggctccaat cggaaatcaa catggcagcg   4860

acggaaacac gagacctgcg gaacatgacc gtggcggact ctgggaccaa ccatgactcc   4920

agactgtggt ccctggagag ggaactggat gacctcaaga ggctctccaa ggacaaagac   4980

ctcgagatcg acgagctgca gaagcgcctg ggctccgtgg ccgtcaagcg ggagcagcgg   5040

gagaaccacc tgcggcgctc catcgtagtc atccaccctg acacaggccg cgagctgtcc   5100

ccggaggaag cccaccgtgc cgggctcatt gactggaaca tgttcgtgaa actcagaagc   5160

caggagtgcg actgggagga gatctcagtg aagggtccca atggggagtc ctcagtgata   5220

cacgacagga agtctggcaa gaagttctcc atcgaagagg ccctgcagag tggcaggctg   5280

acccctgctc agtatgaccg ctatgtcaac aaggatatgt ccatccagga gctggcggtc   5340

ttggtatctg ggcagaagta ggcacagctc ttgcaactct tcgtaacggc agacgctggc   5400

cctctcctac gacgcagtga cctccttggt gtcgtcctct ccctagccct ggtgcaggcc   5460

aagcatttta tacataccct cgctgccagg ctgctcagag tcccgcccac atatgagaca   5520

ggcactggct gaagacaggc aactctcgtc ccaaccatca ttcaccctga gtgacgtact   5580

tcatcctcca atgactggac aactgcgatg ccttttcctc ccttttcctg tacactccca   5640

gcaacaaact cctcatgata actgcacaca atctgaaaac cactgaagga caagccaacc   5700

acagcagcca agcccactcc ttgcagcatg ggtactggtg gcacaccaga cagtgacact   5760

gccccacaaa ggcctgggcc cgtgggggct gctgcctggc atgacatctc tccagatttc   5820

tggcttaaaa ccaactttcc atccgagaag cctcctcagt agttactctg ctcatgagac   5880

agatctgggc tccaagccag gaaaggtgaa cagaaaccac aagtgtccag ccctcggtgc   5940

tggagtggac gttaattgtc agccaccaga ctgtcccggc acctacagag aatgtttcac   6000

agttctggca tttaaatcct ttgatagtgg attgtgctgc tgttagcctt agtttcagtg   6060

ctttacaagt ctcgcttatt atctcactgg tatttaggta tacaaaacag ttgattattc   6120

accacgccaa tatctgggtc tctgtatctc atgtagaaca taagaaaatg ggaactaata   6180

gggaaattta tttatagcat gaaaataaac ctggtggctg gagtctgctt gtacggtcaa   6240

aaaaaaaaaa aaaaaa                                                   6256


<210>  172
<211>  1756
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Asn Ser Leu Phe Arg Lys Arg Asn Lys Gly Lys Tyr Ser Pro Thr 
1               5                   10                  15      


Val Gln Thr Arg Ser Ile Ser Asn Lys Glu Leu Ser Glu Leu Ile Glu 
            20                  25                  30          


Gln Leu Gln Lys Asn Ala Asp Gln Val Glu Lys Asn Ile Val Asp Thr 
        35                  40                  45              


Glu Ala Lys Met Gln Ser Asp Leu Ala Arg Leu Gln Glu Gly Arg Gln 
    50                  55                  60                  


Pro Glu His Arg Asp Val Thr Leu Gln Lys Val Leu Asp Ser Glu Lys 
65                  70                  75                  80  


Leu Leu Tyr Val Leu Glu Ala Asp Ala Ala Ile Ala Lys His Met Lys 
                85                  90                  95      


His Pro Gln Gly Asp Met Ile Ala Glu Asp Ile Arg Gln Leu Lys Glu 
            100                 105                 110         


Arg Val Thr Asn Leu Arg Gly Lys His Lys Gln Ile Tyr Arg Leu Ala 
        115                 120                 125             


Val Lys Glu Val Asp Pro Gln Val Asn Trp Ala Ala Leu Val Glu Glu 
    130                 135                 140                 


Lys Leu Asp Lys Leu Asn Asn Gln Ser Phe Gly Thr Asp Leu Pro Leu 
145                 150                 155                 160 


Val Asp His Gln Val Glu Glu His Asn Ile Phe His Asn Glu Val Lys 
                165                 170                 175     


Ala Ile Gly Pro His Leu Ala Lys Asp Gly Asp Lys Glu Gln Asn Ser 
            180                 185                 190         


Glu Leu Arg Ala Lys Tyr Gln Lys Leu Leu Ala Ala Ser Gln Ala Arg 
        195                 200                 205             


Gln Gln His Leu Ser Ser Leu Gln Asp Tyr Met Gln Arg Cys Thr Asn 
    210                 215                 220                 


Glu Leu Tyr Trp Leu Asp Gln Gln Ala Lys Gly Arg Met Gln Tyr Asp 
225                 230                 235                 240 


Trp Ser Asp Arg Asn Leu Asp Tyr Pro Ser Arg Arg Arg Gln Tyr Glu 
                245                 250                 255     


Asn Phe Ile Asn Arg Asn Leu Glu Ala Lys Glu Glu Arg Ile Asn Lys 
            260                 265                 270         


Leu His Ser Glu Gly Asp Gln Leu Leu Ala Ala Glu His Pro Gly Arg 
        275                 280                 285             


Asn Ser Ile Glu Ala His Met Glu Ala Val His Ala Asp Trp Lys Glu 
    290                 295                 300                 


Tyr Leu Asn Leu Leu Ile Cys Glu Glu Ser His Leu Lys Tyr Met Glu 
305                 310                 315                 320 


Asp Tyr His Gln Phe His Glu Asp Val Lys Asp Ala Gln Glu Leu Leu 
                325                 330                 335     


Arg Lys Val Asp Ser Asp Leu Asn Gln Lys Tyr Gly Pro Asp Phe Lys 
            340                 345                 350         


Asp Arg Tyr Gln Ile Glu Leu Leu Leu Arg Glu Leu Asp Asp Gln Glu 
        355                 360                 365             


Lys Val Leu Asp Lys Tyr Glu Asp Val Val Gln Gly Leu Gln Lys Arg 
    370                 375                 380                 


Gly Gln Gln Val Val Pro Leu Lys Tyr Arg Arg Glu Thr Pro Leu Lys 
385                 390                 395                 400 


Pro Ile Pro Val Glu Ala Leu Cys Asp Phe Glu Gly Glu Gln Gly Leu 
                405                 410                 415     


Ile Ser Arg Gly Tyr Ser Tyr Thr Leu Gln Lys Asn Asn Gly Glu Ser 
            420                 425                 430         


Trp Glu Leu Met Asp Ser Ala Gly Asn Lys Leu Ile Ala Pro Ala Val 
        435                 440                 445             


Cys Phe Val Ile Pro Pro Thr Asp Pro Glu Ala Leu Ala Leu Ala Asp 
    450                 455                 460                 


Ser Leu Gly Ser Gln Tyr Arg Ser Val Arg Gln Lys Ala Ala Gly Ser 
465                 470                 475                 480 


Lys Arg Thr Leu Gln Gln Arg Tyr Glu Val Leu Lys Thr Glu Asn Pro 
                485                 490                 495     


Gly Asp Ala Ser Asp Leu Gln Gly Arg Gln Leu Leu Ala Gly Leu Asp 
            500                 505                 510         


Lys Val Ala Ser Asp Leu Asp Arg Gln Glu Lys Ala Ile Thr Gly Ile 
        515                 520                 525             


Leu Arg Pro Pro Leu Glu Gln Gly Arg Ala Val Gln Asp Ser Ala Glu 
    530                 535                 540                 


Arg Ala Lys Asp Leu Lys Asn Ile Thr Asn Glu Leu Leu Arg Ile Glu 
545                 550                 555                 560 


Pro Glu Lys Thr Arg Ser Thr Ala Glu Gly Glu Ala Phe Ile Gln Ala 
                565                 570                 575     


Leu Pro Gly Ser Gly Thr Thr Pro Leu Leu Arg Thr Arg Val Glu Asp 
            580                 585                 590         


Thr Asn Arg Lys Tyr Glu His Leu Leu Gln Leu Leu Asp Leu Ala Gln 
        595                 600                 605             


Glu Lys Val Asp Val Ala Asn Arg Leu Glu Lys Ser Leu Gln Gln Ser 
    610                 615                 620                 


Trp Glu Leu Leu Ala Thr His Glu Asn His Leu Asn Gln Asp Asp Thr 
625                 630                 635                 640 


Val Pro Glu Ser Ser Arg Val Leu Asp Ser Lys Gly Gln Glu Leu Ala 
                645                 650                 655     


Ala Met Ala Cys Glu Leu Gln Ala Gln Lys Ser Leu Leu Gly Glu Val 
            660                 665                 670         


Glu Gln Asn Leu Gln Ala Ala Lys Gln Cys Ser Ser Thr Leu Ala Ser 
        675                 680                 685             


Arg Phe Gln Glu His Cys Pro Asp Leu Glu Arg Gln Glu Ala Glu Val 
    690                 695                 700                 


His Lys Leu Gly Gln Arg Phe Asn Asn Leu Arg Gln Gln Val Glu Arg 
705                 710                 715                 720 


Arg Ala Gln Ser Leu Gln Ser Ala Lys Ala Ala Tyr Glu His Phe His 
                725                 730                 735     


Arg Gly His Asp His Val Leu Gln Phe Leu Val Ser Ile Pro Ser Tyr 
            740                 745                 750         


Glu Pro Gln Glu Thr Asp Ser Leu Ser Gln Met Glu Thr Lys Leu Lys 
        755                 760                 765             


Asn Gln Lys Asn Leu Leu Asp Glu Ile Ala Ser Arg Glu Gln Glu Val 
    770                 775                 780                 


Gln Lys Ile Cys Ala Asn Ser Gln Gln Tyr Gln Gln Ala Val Lys Asp 
785                 790                 795                 800 


Tyr Glu Leu Glu Ala Glu Lys Leu Arg Ser Leu Leu Asp Leu Glu Asn 
                805                 810                 815     


Gly Arg Ser Ser His Val Ser Lys Arg Ala Arg Leu Gln Ser Pro Ala 
            820                 825                 830         


Thr Lys Val Lys Glu Glu Glu Ala Ala Leu Ala Ala Lys Phe Thr Glu 
        835                 840                 845             


Val Tyr Ala Ile Asn Arg Gln Arg Leu Gln Asn Leu Glu Phe Ala Leu 
    850                 855                 860                 


Asn Leu Leu Arg Gln Gln Pro Glu Val Glu Val Thr His Glu Thr Leu 
865                 870                 875                 880 


Gln Arg Asn Arg Pro Asp Ser Gly Val Glu Glu Ala Trp Lys Ile Arg 
                885                 890                 895     


Lys Glu Leu Asp Glu Glu Thr Glu Arg Arg Arg Gln Leu Glu Asn Glu 
            900                 905                 910         


Val Lys Ser Thr Gln Glu Glu Ile Trp Thr Leu Arg Asn Gln Gly Pro 
        915                 920                 925             


Gln Glu Ser Val Val Arg Lys Glu Val Leu Lys Lys Val Pro Asp Pro 
    930                 935                 940                 


Val Leu Glu Glu Ser Phe Gln Gln Leu Gln Arg Thr Leu Ala Glu Glu 
945                 950                 955                 960 


Gln His Lys Asn Gln Leu Leu Gln Glu Glu Leu Glu Ala Leu Gln Leu 
                965                 970                 975     


Gln Leu Arg Ala Leu Glu Gln Glu Thr Arg Asp Gly Gly Gln Glu Tyr 
            980                 985                 990         


Val Val Lys Glu Val Leu Arg Ile  Glu Pro Asp Arg Ala  Gln Ala Asp 
        995                 1000                 1005             


Glu Val  Leu Gln Leu Arg Glu  Glu Leu Glu Ala Leu  Arg Arg Gln 
    1010                 1015                 1020             


Lys Gly  Ala Arg Glu Ala Glu  Val Leu Leu Leu Gln  Gln Arg Val 
    1025                 1030                 1035             


Ala Ala  Leu Ala Glu Glu Lys  Ser Arg Ala Gln Glu  Lys Val Thr 
    1040                 1045                 1050             


Glu Lys  Glu Val Val Lys Leu  Gln Asn Asp Pro Gln  Leu Glu Ala 
    1055                 1060                 1065             


Glu Tyr  Gln Gln Leu Gln Glu  Asp His Gln Arg Gln  Asp Gln Leu 
    1070                 1075                 1080             


Arg Glu  Lys Gln Glu Glu Glu  Leu Ser Phe Leu Gln  Asp Lys Leu 
    1085                 1090                 1095             


Lys Arg  Leu Glu Lys Glu Arg  Ala Met Ala Glu Gly  Lys Ile Thr 
    1100                 1105                 1110             


Val Lys  Glu Val Leu Lys Val  Glu Lys Asp Ala Ala  Thr Glu Arg 
    1115                 1120                 1125             


Glu Val  Ser Asp Leu Thr Arg  Gln Tyr Glu Asp Glu  Ala Ala Lys 
    1130                 1135                 1140             


Ala Arg  Ala Ser Gln Arg Glu  Lys Thr Glu Leu Leu  Arg Lys Ile 
    1145                 1150                 1155             


Trp Ala  Leu Glu Glu Glu Asn  Ala Lys Val Val Val  Gln Glu Lys 
    1160                 1165                 1170             


Val Arg  Glu Ile Val Arg Pro  Asp Pro Lys Ala Glu  Ser Glu Val 
    1175                 1180                 1185             


Ala Asn  Leu Arg Leu Glu Leu  Val Glu Gln Glu Arg  Lys Tyr Arg 
    1190                 1195                 1200             


Gly Ala  Glu Glu Gln Leu Arg  Ser Tyr Gln Ser Glu  Leu Glu Ala 
    1205                 1210                 1215             


Leu Arg  Arg Arg Gly Pro Gln  Val Glu Val Lys Glu  Val Thr Lys 
    1220                 1225                 1230             


Glu Val  Ile Lys Tyr Lys Thr  Asp Pro Glu Met Glu  Lys Glu Leu 
    1235                 1240                 1245             


Gln Arg  Leu Arg Glu Glu Ile  Val Asp Lys Thr Arg  Leu Ile Glu 
    1250                 1255                 1260             


Arg Cys  Asp Leu Glu Ile Tyr  Gln Leu Lys Lys Glu  Ile Gln Ala 
    1265                 1270                 1275             


Leu Lys  Asp Thr Lys Pro Gln  Val Gln Thr Lys Glu  Val Val Gln 
    1280                 1285                 1290             


Glu Ile  Leu Gln Phe Gln Glu  Asp Pro Gln Thr Lys  Glu Glu Val 
    1295                 1300                 1305             


Ala Ser  Leu Arg Ala Lys Leu  Ser Glu Glu Gln Lys  Lys Gln Val 
    1310                 1315                 1320             


Asp Leu  Glu Arg Glu Arg Ala  Ser Gln Glu Glu Gln  Ile Ala Arg 
    1325                 1330                 1335             


Lys Glu  Glu Glu Leu Ser Arg  Val Lys Glu Arg Val  Val Gln Gln 
    1340                 1345                 1350             


Glu Val  Val Arg Tyr Glu Glu  Glu Pro Gly Leu Arg  Ala Glu Ala 
    1355                 1360                 1365             


Ser Ala  Phe Ala Glu Ser Ile  Asp Val Glu Leu Arg  Gln Ile Asp 
    1370                 1375                 1380             


Lys Leu  Arg Ala Glu Leu Arg  Arg Leu Gln Arg Arg  Arg Thr Glu 
    1385                 1390                 1395             


Leu Glu  Arg Gln Leu Glu Glu  Leu Glu Arg Glu Arg  Gln Ala Arg 
    1400                 1405                 1410             


Arg Glu  Ala Glu Arg Glu Val  Gln Arg Leu Gln Gln  Arg Leu Ala 
    1415                 1420                 1425             


Ala Leu  Glu Gln Glu Glu Ala  Glu Ala Arg Glu Lys  Val Thr His 
    1430                 1435                 1440             


Thr Gln  Lys Val Val Leu Gln  Gln Asp Pro Gln Gln  Ala Arg Glu 
    1445                 1450                 1455             


His Ala  Leu Leu Arg Leu Gln  Leu Glu Glu Glu Gln  His Arg Arg 
    1460                 1465                 1470             


Gln Leu  Leu Glu Gly Glu Leu  Glu Thr Leu Arg Arg  Lys Leu Ala 
    1475                 1480                 1485             


Ala Leu  Glu Lys Ala Glu Val  Lys Glu Lys Val Val  Leu Ser Glu 
    1490                 1495                 1500             


Ser Val  Gln Val Glu Lys Gly  Asp Thr Glu Gln Glu  Ile Gln Arg 
    1505                 1510                 1515             


Leu Lys  Ser Ser Leu Glu Glu  Glu Ser Arg Ser Lys  Arg Glu Leu 
    1520                 1525                 1530             


Asp Val  Glu Val Ser Arg Leu  Glu Ala Arg Leu Ser  Glu Leu Glu 
    1535                 1540                 1545             


Phe His  Asn Ser Lys Ser Ser  Lys Glu Leu Asp Phe  Leu Arg Glu 
    1550                 1555                 1560             


Glu Asn  His Lys Leu Gln Leu  Glu Arg Gln Asn Leu  Gln Leu Glu 
    1565                 1570                 1575             


Thr Arg  Arg Leu Gln Ser Glu  Ile Asn Met Ala Ala  Thr Glu Thr 
    1580                 1585                 1590             


Arg Asp  Leu Arg Asn Met Thr  Val Ala Asp Ser Gly  Thr Asn His 
    1595                 1600                 1605             


Asp Ser  Arg Leu Trp Ser Leu  Glu Arg Glu Leu Asp  Asp Leu Lys 
    1610                 1615                 1620             


Arg Leu  Ser Lys Asp Lys Asp  Leu Glu Ile Asp Glu  Leu Gln Lys 
    1625                 1630                 1635             


Arg Leu  Gly Ser Val Ala Val  Lys Arg Glu Gln Arg  Glu Asn His 
    1640                 1645                 1650             


Leu Arg  Arg Ser Ile Val Val  Ile His Pro Asp Thr  Gly Arg Glu 
    1655                 1660                 1665             


Leu Ser  Pro Glu Glu Ala His  Arg Ala Gly Leu Ile  Asp Trp Asn 
    1670                 1675                 1680             


Met Phe  Val Lys Leu Arg Ser  Gln Glu Cys Asp Trp  Glu Glu Ile 
    1685                 1690                 1695             


Ser Val  Lys Gly Pro Asn Gly  Glu Ser Ser Val Ile  His Asp Arg 
    1700                 1705                 1710             


Lys Ser  Gly Lys Lys Phe Ser  Ile Glu Glu Ala Leu  Gln Ser Gly 
    1715                 1720                 1725             


Arg Leu  Thr Pro Ala Gln Tyr  Asp Arg Tyr Val Asn  Lys Asp Met 
    1730                 1735                 1740             


Ser Ile  Gln Glu Leu Ala Val  Leu Val Ser Gly Gln  Lys 
    1745                 1750                 1755     


<210>  173
<211>  1810
<212>  DNA
<213>  Homo sapiens

<400>  173
ccagcgctgc tccccgggcg ctcctccccg ggcgctcctc cccaggcctc ccgggcgctt     60

ggatcccggc catctccgca cccttcaagt gggtgtgggt gatttcctgg cggggggagc    120

agccaggtga gcccaagatg ctgctgcgct cgaagcctgc gctgccgccg ccgctgatgc    180

tgctgctcct ggggccgctg ggtcccctct cccctggcgc cctgccccga cctgcgcaag    240

cacaggacgt cgtggacctg gacttcttca cccaggagcc gctgcacctg gtgagcccct    300

cgttcctgtc cgtcaccatt gacgccaacc tggccacgga cccgcggttc ctcatcctcc    360

tgggttctcc aaagcttcgt accttggcca gaggcttgtc tcctgcgtac ctgaggtttg    420

gtggcaccaa gacagacttc ctaattttcg atcccaagaa ggaatcaacc tttgaagaga    480

gaagttactg gcaatctcaa gtcaaccagg atatttgcaa atatggatcc atccctcctg    540

atgtggagga gaagttacgg ttggaatggc cctaccagga gcaattgcta ctccgagaac    600

actaccagaa aaagttcaag aacagcacct actcaagaag ctctgtagat gtgctataca    660

cttttgcaaa ctgctcagga ctggacttga tctttggcct aaatgcgtta ttaagaacag    720

cagatttgca gtggaacagt tctaatgctc agttgctcct ggactactgc tcttccaagg    780

ggtataacat ttcttgggaa ctaggcaatg aacctaacag tttccttaag aaggctgata    840

ttttcatcaa tgggtcgcag ttaggagaag attttattca attgcataaa cttctaagaa    900

agtccacctt caaaaatgca aaactctatg gtcctgatgt tggtcagcct cgaagaaaga    960

cggctaagat gctgaagagc ttcctgaagg ctggtggaga agtgattgat tcagttacat   1020

ggcatcacta ctatttgaat ggacggactg ctaccaagga agattttcta aaccctgatg   1080

tattggacat ttttatttca tctgtgcaaa aagttttcca ggtggttgag agcaccaggc   1140

ctggcaagaa ggtctggtta ggagaaacaa gctctgcata tggaggcgga gcgcccttgc   1200

tatccgacac ctttgcagct ggctttatgt ggctggataa attgggcctg tcagcccgaa   1260

tgggaataga agtggtgatg aggcaagtat tctttggagc aggaaactac catttagtgg   1320

atgaaaactt cgatccttta cctgattatt ggctatctct tctgttcaag aaattggtgg   1380

gcaccaaggt gttaatggca agcgtgcaag gttcaaagag aaggaagctt cgagtatacc   1440

ttcattgcac aaacactgac aatccaaggt ataaagaagg agatttaact ctgtatgcca   1500

taaacctcca taatgtcacc aagtacttgc ggttacccta tcctttttct aacaagcaag   1560

tggataaata ccttctaaga cctttgggac ctcatggatt actttccaaa tctgtccaac   1620

tcaatggtct aactctaaag atggtggatg atcaaacctt gccaccttta atggaaaaac   1680

ctctccggcc aggaagttca ctgggcttgc cagctttctc atatagtttt tttgtgataa   1740

gaaatgccaa agttgctgct tgcatctgaa aataaaatat actagtcctg acaaaaaaaa   1800

aaaaaaaaaa                                                          1810


<210>  174
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly 
                325                 330                 335     


Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala 
            340                 345                 350         


Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys 
        355                 360                 365             


Leu Gly Leu Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val 
    370                 375                 380                 


Phe Phe Gly Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro 
385                 390                 395                 400 


Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr 
                405                 410                 415     


Lys Val Leu Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg 
            420                 425                 430         


Val Tyr Leu His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly 
        435                 440                 445             


Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu 
    450                 455                 460                 


Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu 
465                 470                 475                 480 


Arg Pro Leu Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn 
                485                 490                 495     


Gly Leu Thr Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met 
            500                 505                 510         


Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser 
        515                 520                 525             


Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile 
    530                 535                 540             


<210>  175
<211>  1426
<212>  DNA
<213>  Homo sapiens

<400>  175
ggatccgcgt gctaaagaaa aatcgccgtt aaagcagttt tctttttcac tgtctttttc     60

ttttcgcggg gaacccagct gttcctgcga gggccacctc ctcaggaaga ccccgcagct    120

ctcccgcggc gcttctgcag gaggcagcga cagtttcgag aacccgggcc ttcccctccc    180

agtgcctccg ggggttcgcg tttcaggcgc tcgtgttttc cgggaagggc aggcgcgctg    240

ggccttgggg agctgcgctc ggcgggcgga ccgggggatc atggaagctg ataaagatga    300

cacacaacaa attcttaagg agcattcgcc agatgaattt ataaaagatg aacaaaataa    360

gggactaatt gatgaaatta caaagaaaaa tattcagcta aagaaggaga tccaaaagct    420

tgaaacggag ttacaagagg ctaccaaaga attccagatt aaagaggata ttcctgaaac    480

aaagatgaaa ttcttatcag ttgaaactcc tgagaatgac agccagttgt caaatatctc    540

ctgttcgttt caagtgagct cgaaagttcc ttatgagata caaaaaggac aagcacttat    600

cacctttgaa aaagaagaag ttgctcaaaa tgtggtaagc atgagtaaac atcatgtaca    660

gataaaagat gtaaatctgg aggttacggc caagccagtt ccattaaatt caggagtcag    720

attccaggtt tatgtagaag tttctaaaat gaaaatcaat gttactgaaa ttcctgacac    780

actgcgtgaa gatcaaatga gagacaaact agagctgagc ttttcaaagt tccgaaatgg    840

aggcggagag gtggaccgcg tggactatga cagacagtcc gggagtgcag tcatcacgtt    900

tgtggagatt ggagtggctg acaagatttt gaaaaagaaa gaataccctc tttatataaa    960

tcaaacctgc catagagtta ctgtttctcc atacacagaa atacacttga aaaagtatca   1020

gatattttca ggaacatcta agaggacagt gcttctgaca ggaatggaag gcattcaaat   1080

ggatgaagaa attgtggagg atttaattaa cattcacttt caacgggcaa agaatggagg   1140

tggagaagta gatgtggtca agtgttctct aggtcaacct cacatagcat actttgaaga   1200

atagacttaa cagaatcatg aaaactatag ctttttaacc cggattactg taaatgtttg   1260

acaagaatga atatgctttt ccttaaaaaa tgaaaacttt aatttttacc atccatttat   1320

gtttagatac aaaacttatt tccatgtttc tgaatcttct ttgtttcaaa tggtgctgca   1380

tgttttcaac tacaataagt gcactgtaat aaaaagtttt gtttat                  1426


<210>  176
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Glu Ala Asp Lys Asp Asp Thr Gln Gln Ile Leu Lys Glu His Ser 
1               5                   10                  15      


Pro Asp Glu Phe Ile Lys Asp Glu Gln Asn Lys Gly Leu Ile Asp Glu 
            20                  25                  30          


Ile Thr Lys Lys Asn Ile Gln Leu Lys Lys Glu Ile Gln Lys Leu Glu 
        35                  40                  45              


Thr Glu Leu Gln Glu Ala Thr Lys Glu Phe Gln Ile Lys Glu Asp Ile 
    50                  55                  60                  


Pro Glu Thr Lys Met Lys Phe Leu Ser Val Glu Thr Pro Glu Asn Asp 
65                  70                  75                  80  


Ser Gln Leu Ser Asn Ile Ser Cys Ser Phe Gln Val Ser Ser Lys Val 
                85                  90                  95      


Pro Tyr Glu Ile Gln Lys Gly Gln Ala Leu Ile Thr Phe Glu Lys Glu 
            100                 105                 110         


Glu Val Ala Gln Asn Val Val Ser Met Ser Lys His His Val Gln Ile 
        115                 120                 125             


Lys Asp Val Asn Leu Glu Val Thr Ala Lys Pro Val Pro Leu Asn Ser 
    130                 135                 140                 


Gly Val Arg Phe Gln Val Tyr Val Glu Val Ser Lys Met Lys Ile Asn 
145                 150                 155                 160 


Val Thr Glu Ile Pro Asp Thr Leu Arg Glu Asp Gln Met Arg Asp Lys 
                165                 170                 175     


Leu Glu Leu Ser Phe Ser Lys Phe Arg Asn Gly Gly Gly Glu Val Asp 
            180                 185                 190         


Arg Val Asp Tyr Asp Arg Gln Ser Gly Ser Ala Val Ile Thr Phe Val 
        195                 200                 205             


Glu Ile Gly Val Ala Asp Lys Ile Leu Lys Lys Lys Glu Tyr Pro Leu 
    210                 215                 220                 


Tyr Ile Asn Gln Thr Cys His Arg Val Thr Val Ser Pro Tyr Thr Glu 
225                 230                 235                 240 


Ile His Leu Lys Lys Tyr Gln Ile Phe Ser Gly Thr Ser Lys Arg Thr 
                245                 250                 255     


Val Leu Leu Thr Gly Met Glu Gly Ile Gln Met Asp Glu Glu Ile Val 
            260                 265                 270         


Glu Asp Leu Ile Asn Ile His Phe Gln Arg Ala Lys Asn Gly Gly Gly 
        275                 280                 285             


Glu Val Asp Val Val Lys Cys Ser Leu Gly Gln Pro His Ile Ala Tyr 
    290                 295                 300                 


Phe Glu Glu 
305         


<210>  177
<211>  2077
<212>  DNA
<213>  Homo sapiens

<400>  177
ccgagcgcca gcgcggggaa ccgggaaaag gaaaccgtgt tgtgtacgta agattcagga     60

aacgaaacca ggagccgcgg gtgttggcgc aaaggttact cccagaccct tttccggctg    120

acttctgaga aggttgcgca cagctgtgcc cggcagtcta gaggcgcaga agaggaagcc    180

atcgcctggc cccggctctc tggaccttgt ctcgctcggg agcggaaaca gcggcagcca    240

gagaactgtt ttaatcatgg acaaacaaaa ctcacagatg aatgcttctc acccggaaac    300

aaacttgcca gttgggtatc ctcctcagta tccaccgaca gcattccaag gacctccagg    360

atatagtggc taccctgggc cccaggtcag ctacccaccc ccaccagccg gccattcagg    420

tcctggccca gctggctttc ctgtcccaaa tcagccagtg tataatcagc cagtatataa    480

tcagccagtt ggagctgcag gggtaccatg gatgccagcg ccacagcctc cattaaactg    540

tccacctgga ttagaatatt taagtcagat agatcagata ctgattcatc agcaaattga    600

acttctggaa gttttaacag gttttgaaac taataacaaa tatgaaatta agaacagctt    660

tggacagagg gtttactttg cagcggaaga tactgattgc tgtacccgaa attgctgtgg    720

gccatctaga ccttttacct tgaggattat tgataatatg ggtcaagaag tcataactct    780

ggagagacca ctaagatgta gcagctgttg ttgtccctgc tgccttcagg agatagaaat    840

ccaagctcct cctggtgtac caataggtta tgttattcag acttggcacc catgtctacc    900

aaagtttaca attcaaaatg agaaaagaga ggatgtacta aaaataagtg gtccatgtgt    960

tgtgtgcagc tgttgtggag atgttgattt tgagattaaa tctcttgatg aacagtgtgt   1020

ggttggcaaa atttccaagc actggactgg aattttgaga gaggcattta cagacgctga   1080

taactttgga atccagttcc ctttagacct tgatgttaaa atgaaagctg taatgattgg   1140

tgcctgtttc ctcattgact tcatgttttt tgaaagcact ggcagccagg aacaaaaatc   1200

aggagtgtgg tagtggatta gtgaaagtct cctcaggaaa tctgaagtct gtatattgat   1260

tgagactatc taaactcata cctgtatgaa ttaagctgta aggcctgtag ctctggttgt   1320

atacttttgc ttttcaaatt atagtttatc ttctgtataa ctgatttata aaggtttttg   1380

tacatttttt aatactcatt gtcaatttga gaaaaaggac atatgagttt ttgcatttat   1440

taatgaaact tcctttgaaa aactgctttg aattatgatc tctgattcat tgtccatttt   1500

actaccaaat attaactaag gccttattaa tttttatata aattatatct tgtcctatta   1560

aatctagtta caatttattt catgcataag agctaatgtt attttgcaaa tgccatatat   1620

tcaaaaaagc tcaaagataa ttttctttac tattatgttc aaataatatt caatatgcat   1680

attatcttta aaaagttaaa tgttttttta atcttcaaga aatcatgcta cacttaactt   1740

ctcctagaag ctaatctata ccataatatt ttcatattca caagatatta aattaccaat   1800

tttcaaatta ttgttagtaa agaacaaaat gattctctcc caaagaaaga cacattttaa   1860

atactccttc actctaaaac tctggtatta taacttttga aagttaatat ttctacatga   1920

aatgtttagc tcttacactc tatccttcct agaaaatggt aattgagatt actcagatat   1980

taattaaata caatatcata tatatattca cagagtataa acctaaataa tgatctatta   2040

gattcaaata tttgaaataa aaacttgatt tttttgt                            2077


<210>  178
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Asp Lys Gln Asn Ser Gln Met Asn Ala Ser His Pro Glu Thr Asn 
1               5                   10                  15      


Leu Pro Val Gly Tyr Pro Pro Gln Tyr Pro Pro Thr Ala Phe Gln Gly 
            20                  25                  30          


Pro Pro Gly Tyr Ser Gly Tyr Pro Gly Pro Gln Val Ser Tyr Pro Pro 
        35                  40                  45              


Pro Pro Ala Gly His Ser Gly Pro Gly Pro Ala Gly Phe Pro Val Pro 
    50                  55                  60                  


Asn Gln Pro Val Tyr Asn Gln Pro Val Tyr Asn Gln Pro Val Gly Ala 
65                  70                  75                  80  


Ala Gly Val Pro Trp Met Pro Ala Pro Gln Pro Pro Leu Asn Cys Pro 
                85                  90                  95      


Pro Gly Leu Glu Tyr Leu Ser Gln Ile Asp Gln Ile Leu Ile His Gln 
            100                 105                 110         


Gln Ile Glu Leu Leu Glu Val Leu Thr Gly Phe Glu Thr Asn Asn Lys 
        115                 120                 125             


Tyr Glu Ile Lys Asn Ser Phe Gly Gln Arg Val Tyr Phe Ala Ala Glu 
    130                 135                 140                 


Asp Thr Asp Cys Cys Thr Arg Asn Cys Cys Gly Pro Ser Arg Pro Phe 
145                 150                 155                 160 


Thr Leu Arg Ile Ile Asp Asn Met Gly Gln Glu Val Ile Thr Leu Glu 
                165                 170                 175     


Arg Pro Leu Arg Cys Ser Ser Cys Cys Cys Pro Cys Cys Leu Gln Glu 
            180                 185                 190         


Ile Glu Ile Gln Ala Pro Pro Gly Val Pro Ile Gly Tyr Val Ile Gln 
        195                 200                 205             


Thr Trp His Pro Cys Leu Pro Lys Phe Thr Ile Gln Asn Glu Lys Arg 
    210                 215                 220                 


Glu Asp Val Leu Lys Ile Ser Gly Pro Cys Val Val Cys Ser Cys Cys 
225                 230                 235                 240 


Gly Asp Val Asp Phe Glu Ile Lys Ser Leu Asp Glu Gln Cys Val Val 
                245                 250                 255     


Gly Lys Ile Ser Lys His Trp Thr Gly Ile Leu Arg Glu Ala Phe Thr 
            260                 265                 270         


Asp Ala Asp Asn Phe Gly Ile Gln Phe Pro Leu Asp Leu Asp Val Lys 
        275                 280                 285             


Met Lys Ala Val Met Ile Gly Ala Cys Phe Leu Ile Asp Phe Met Phe 
    290                 295                 300                 


Phe Glu Ser Thr Gly Ser Gln Glu Gln Lys Ser Gly Val Trp 
305                 310                 315             


<210>  179
<211>  1270
<212>  DNA
<213>  Homo sapiens

<400>  179
attttctaaa agggacagag agcaccctgc tacatttcct aatcaagaag ttggcgtgca     60

gctgggagag ctagactaag ttggtcatga tgcagaagct actcaaatgc agtcggcttg    120

tcctggctct tgccctcatc ctggttctgg aatcctcagt tcaaggttat cctacgcgga    180

gagccaggta ccaatgggtg cgctgcaatc cagacagtaa ttctgcaaac tgccttgaag    240

aaaaaggacc aatgttcgaa ctacttccag gtgaatccaa caagatcccc cgtctgagga    300

ctgacctttt tccaaagacg agaatccagg acttgaatcg tatcttccca ctttctgagg    360

actactctgg atcaggcttc ggctccggct ccggctctgg atcaggatct gggagtggct    420

tcctaacgga aatggaacag gattaccaac tagtagacga aagtgatgct ttccatgaca    480

accttaggtc tcttgacagg aatctgccct cagacagcca ggacttgggt caacatggat    540

tagaagagga ttttatgtta taaaagagga ttttcccacc ttgacaccag gcaatgtagt    600

tagcatattt tatgtaccat ggttatatga ttaatcttgg gacaaagaat tttatagaaa    660

tttttaaaca tctgaaaaag aagcttaagt tttatcatcc ttttttttct catgaattct    720

taaaggatta tgctttaatg ctgttatcta ttttattgtt cttgaaaata cctgcatttt    780

ttggtatcat gttcaaccaa catcattatg aaattaatta gattcccatg gccataaaat    840

ggctttaaag aatatatata tatttttaaa gtagcttgag aagcaaattg gcaggtaata    900

tttcatacct aaattaagac tctgacttgg attgtgaatt ataatgatat gccccttttc    960

ttataaaaac aaaaaaaaaa ataatgaaac acagtgaatt tgtagagtgg gggtatttga   1020

catattttac agggtggagt gtactatata ctattacctt tgaatgtgtt tgcagagcta   1080

gtggatgtgt ttgtctacaa gtatgattgc tgttacataa caccccaaat taactcccaa   1140

attaaaacac agttgtgctg tcaatacctc atactgcttt accttttttt cctggatatc   1200

tgtgtatttt caaatgttac tatatattaa agcagaaata taaccaaagg ttaaaaaaaa   1260

aaaaaaaaaa                                                          1270


<210>  180
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Met Gln Lys Leu Leu Lys Cys Ser Arg Leu Val Leu Ala Leu Ala 
1               5                   10                  15      


Leu Ile Leu Val Leu Glu Ser Ser Val Gln Gly Tyr Pro Thr Arg Arg 
            20                  25                  30          


Ala Arg Tyr Gln Trp Val Arg Cys Asn Pro Asp Ser Asn Ser Ala Asn 
        35                  40                  45              


Cys Leu Glu Glu Lys Gly Pro Met Phe Glu Leu Leu Pro Gly Glu Ser 
    50                  55                  60                  


Asn Lys Ile Pro Arg Leu Arg Thr Asp Leu Phe Pro Lys Thr Arg Ile 
65                  70                  75                  80  


Gln Asp Leu Asn Arg Ile Phe Pro Leu Ser Glu Asp Tyr Ser Gly Ser 
                85                  90                  95      


Gly Phe Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Phe 
            100                 105                 110         


Leu Thr Glu Met Glu Gln Asp Tyr Gln Leu Val Asp Glu Ser Asp Ala 
        115                 120                 125             


Phe His Asp Asn Leu Arg Ser Leu Asp Arg Asn Leu Pro Ser Asp Ser 
    130                 135                 140                 


Gln Asp Leu Gly Gln His Gly Leu Glu Glu Asp Phe Met Leu 
145                 150                 155             


<210>  181
<211>  2379
<212>  DNA
<213>  Homo sapiens

<400>  181
gagagtcggc gcccgcaacg cggagccggg aagtcgtcgc tactctggtg gaactcagag     60

ttggttctgg aggcggcgga cgcggaggtc cctcagagga tccagcgagg ggcgccaaca    120

agaggcgaag aggtggcacc agggcggcgg caggaagagg agcgggagca ggagcgcgga    180

gcggagcgtc ccgacccgcc gtgcgtactt tctggaggga aggggcgggg gaatcggccc    240

ctgagggaag cgcccggtgg cgagggggtt agccaagttc cggctgcggc gccactccct    300

cggttccacg agaggaaagt tttttttttc cagacgcttc cgccggctcg cgccctccgg    360

gcccagcctc ccgagccttc ggagcgggcg ccgtcccagc ccagctccgg ggaaacgcga    420

gccgcgatgc ctggggggtg ctcccggggc cccgccgccg gggacgggcg tctgcggctg    480

gcgcgactag cgctggtact cctgggctgg gtctcctcgt cttctcccac ctcctcggca    540

tcctccttct cctcctcggc gccgttcctg gcttccgccg tgtccgccca gcccccgctg    600

ccggaccagt gccccgcgct gtgcgagtgc tccgaggcag cgcgcacagt caagtgcgtt    660

aaccgcaatc tgaccgaggt gcccacggac ctgcccgcct acgtgcgcaa cctcttcctt    720

accggcaacc agctggccgt gctccctgcc ggcgccttcg cccgccggcc gccgctggcg    780

gagctggccg cgctcaacct cagcggcagc cgcctggacg aggtgcgcgc gggcgccttc    840

gagcatctgc ccagcctgcg ccagctcgac ctcagccaca acccactggc cgacctcagt    900

cccttcgctt tctcgggcag caatgccagc gtctcggccc ccagtcccct tgtggaactg    960

atcctgaacc acatcgtgcc ccctgaagat gagcggcaga accggagctt cgagggcatg   1020

gtggtggcgg ccctgctggc gggccgtgca ctgcaggggc tccgccgctt ggagctggcc   1080

agcaaccact tcctttacct gccgcgggat gtgctggccc aactgcccag cctcaggcac   1140

ctggacttaa gtaataattc gctggtgagc ctgacctacg tgtccttccg caacctgaca   1200

catctagaaa gcctccacct ggaggacaat gccctcaagg tccttcacaa tggcaccctg   1260

gctgagttgc aaggtctacc ccacattagg gttttcctgg acaacaatcc ctgggtctgc   1320

gactgccaca tggcagacat ggtgacctgg ctcaaggaaa cagaggtagt gcagggcaaa   1380

gaccggctca cctgtgcata tccggaaaaa atgaggaatc gggtcctctt ggaactcaac   1440

agtgctgacc tggactgtga cccgattctt cccccatccc tgcaaacctc ttatgtcttc   1500

ctgggtattg ttttagccct gataggcgct attttcctcc tggttttgta tttgaaccgc   1560

aaggggataa aaaagtggat gcataacatc agagatgcct gcagggatca catggaaggg   1620

tatcattaca gatatgaaat caatgcggac cccagattaa cgaacctcag ttctaactcg   1680

gatgtctgag aaatattaga ggacagacca aggacaactc tgcatgagat gtagacttaa   1740

gctttatccc tactaggctt gctccacttt catcctccac tatagataca acggactttg   1800

actaaaagca gtgaagggga tttgcttcct tgttatgtaa agtttctcgg tgtgttctgt   1860

taatgtaaga cgatgaacag ttgtgtatag tgttttaccc tcttcttttt cttggaactc   1920

ctcaacacgt atggagggat ttttcaggtt tcagcatgaa catgggcttc ttgctgtctg   1980

tctctctctc agtacagttc aaggtgtagc aagtgtaccc acacagatag cattcaacaa   2040

aagctgcctc aactttttcg agaaaaatac tttattcata aatatcagtt ttattctcat   2100

gtacctaagt tgtggagaaa ataattgcat cctataaact gcctgcagac gttagcaggc   2160

tcttcaaaat aactccatgg tgcacaggag cacctgcatc caagagcatg cttacatttt   2220

actgttctgc atattacaaa aaataacttg caacttcata acttctttga caaagtaaat   2280

tacttttttg attgcagttt atatgaaaat gtactgattt ttttttaata aactgcatcg   2340

agatccaacc gactgaattg ttaaaaaaaa aaaaaaaaa                          2379


<210>  182
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Pro Gly Gly Cys Ser Arg Gly Pro Ala Ala Gly Asp Gly Arg Leu 
1               5                   10                  15      


Arg Leu Ala Arg Leu Ala Leu Val Leu Leu Gly Trp Val Ser Ser Ser 
            20                  25                  30          


Ser Pro Thr Ser Ser Ala Ser Ser Phe Ser Ser Ser Ala Pro Phe Leu 
        35                  40                  45              


Ala Ser Ala Val Ser Ala Gln Pro Pro Leu Pro Asp Gln Cys Pro Ala 
    50                  55                  60                  


Leu Cys Glu Cys Ser Glu Ala Ala Arg Thr Val Lys Cys Val Asn Arg 
65                  70                  75                  80  


Asn Leu Thr Glu Val Pro Thr Asp Leu Pro Ala Tyr Val Arg Asn Leu 
                85                  90                  95      


Phe Leu Thr Gly Asn Gln Leu Ala Val Leu Pro Ala Gly Ala Phe Ala 
            100                 105                 110         


Arg Arg Pro Pro Leu Ala Glu Leu Ala Ala Leu Asn Leu Ser Gly Ser 
        115                 120                 125             


Arg Leu Asp Glu Val Arg Ala Gly Ala Phe Glu His Leu Pro Ser Leu 
    130                 135                 140                 


Arg Gln Leu Asp Leu Ser His Asn Pro Leu Ala Asp Leu Ser Pro Phe 
145                 150                 155                 160 


Ala Phe Ser Gly Ser Asn Ala Ser Val Ser Ala Pro Ser Pro Leu Val 
                165                 170                 175     


Glu Leu Ile Leu Asn His Ile Val Pro Pro Glu Asp Glu Arg Gln Asn 
            180                 185                 190         


Arg Ser Phe Glu Gly Met Val Val Ala Ala Leu Leu Ala Gly Arg Ala 
        195                 200                 205             


Leu Gln Gly Leu Arg Arg Leu Glu Leu Ala Ser Asn His Phe Leu Tyr 
    210                 215                 220                 


Leu Pro Arg Asp Val Leu Ala Gln Leu Pro Ser Leu Arg His Leu Asp 
225                 230                 235                 240 


Leu Ser Asn Asn Ser Leu Val Ser Leu Thr Tyr Val Ser Phe Arg Asn 
                245                 250                 255     


Leu Thr His Leu Glu Ser Leu His Leu Glu Asp Asn Ala Leu Lys Val 
            260                 265                 270         


Leu His Asn Gly Thr Leu Ala Glu Leu Gln Gly Leu Pro His Ile Arg 
        275                 280                 285             


Val Phe Leu Asp Asn Asn Pro Trp Val Cys Asp Cys His Met Ala Asp 
    290                 295                 300                 


Met Val Thr Trp Leu Lys Glu Thr Glu Val Val Gln Gly Lys Asp Arg 
305                 310                 315                 320 


Leu Thr Cys Ala Tyr Pro Glu Lys Met Arg Asn Arg Val Leu Leu Glu 
                325                 330                 335     


Leu Asn Ser Ala Asp Leu Asp Cys Asp Pro Ile Leu Pro Pro Ser Leu 
            340                 345                 350         


Gln Thr Ser Tyr Val Phe Leu Gly Ile Val Leu Ala Leu Ile Gly Ala 
        355                 360                 365             


Ile Phe Leu Leu Val Leu Tyr Leu Asn Arg Lys Gly Ile Lys Lys Trp 
    370                 375                 380                 


Met His Asn Ile Arg Asp Ala Cys Arg Asp His Met Glu Gly Tyr His 
385                 390                 395                 400 


Tyr Arg Tyr Glu Ile Asn Ala Asp Pro Arg Leu Thr Asn Leu Ser Ser 
                405                 410                 415     


Asn Ser Asp Val 
            420 


<210>  183
<211>  4759
<212>  DNA
<213>  Homo sapiens

<400>  183
tagttattaa agttcctatg cagctccgcc tcgcgtccgg cctcatttcc tcggaaaatc     60

cctgctttcc ccgctcgcca cgccctcctc ctacccggct ttaaagctag tgaggcacag    120

cctgcgggga acgtagctag ctgcaagcag aggccggcat gaccaccgag cagcgacgca    180

gcctgcaagc cttccaggat tatatccgga agaccctgga ccctacctac atcctgagct    240

acatggcccc ctggtttagg gaggaagagg tgcagtatat tcaggctgag aaaaacaaca    300

agggcccaat ggaggctgcc acactttttc tcaagttcct gttggagctc caggaggaag    360

gctggttccg tggctttttg gatgccctag accatgcagg ttattctgga ctttatgaag    420

ccattgaaag ttgggatttc aaaaaaattg aaaagttgga ggagtataga ttacttttaa    480

aacgtttaca accagaattt aaaaccagaa ttatcccaac cgatatcatt tctgatctgt    540

ctgaatgttt aattaatcag gaatgtgaag aaattctaca gatttgctct actaagggga    600

tgatggcagg tgcagagaaa ttggtggaat gccttctcag atcagacaag gaaaactggc    660

ccaaaacttt gaaacttgct ttggagaaag aaaggaacaa gttcagtgaa ctgtggattg    720

tagagaaagg tataaaagat gttgaaacag aagatcttga ggataagatg gaaacttctg    780

acatacagat tttctaccaa gaagatccag aatgccagaa tcttagtgag aattcatgtc    840

caccttcaga agtgtctgat acaaacttgt acagcccatt taaaccaaga aattaccaat    900

tagagcttgc tttgcctgct atgaaaggaa aaaacacaat aatatgtgct cctacaggtt    960

gtggaaaaac ctttgtttca ctgcttatat gtgaacatca tcttaaaaaa ttcccacaag   1020

gacaaaaggg gaaagttgtc ttttttgcga atcagatccc agtgtatgaa cagcagaaat   1080

ctgtattctc aaaatacttt gaaagacatg ggtatagagt tacaggcatt tctggagcaa   1140

cagctgagaa tgtcccagtg gaacagattg ttgagaacaa tgacatcatc attttaactc   1200

cacagattct tgtgaacaac cttaaaaagg gaacgattcc atcactatcc atctttactt   1260

tgatgatatt tgatgaatgc cacaacacta gtaaacaaca cccgtacaat atgatcatgt   1320

ttaattatct agatcagaaa cttggaggat cttcaggccc actgccccag gtcattgggc   1380

tgactgcctc ggttggtgtt ggggatgcca aaaacacaga tgaagccttg gattatatct   1440

gcaagctgtg tgcttctctt gatgcgtcag tgatagcaac agtcaaacac aatctggagg   1500

aactggagca agttgtttat aagccccaga agtttttcag gaaagtggaa tcacggatta   1560

gcgacaaatt taaatacatc atagctcagc tgatgaggga cacagagagt ctggcaaaga   1620

gaatctgcaa agacctcgaa aacttatctc aaattcaaaa tagggaattt ggaacacaga   1680

aatatgaaca atggattgtt acagttcaga aagcatgcat ggtgttccag atgccagaca   1740

aagatgaaga gagcaggatt tgtaaagccc tgtttttata cacttcacat ttgcggaaat   1800

ataatgatgc cctcattatc agtgagcatg cacgaatgaa agatgctctg gattacttga   1860

aagacttctt cagcaatgtc cgagcagcag gattcgatga gattgagcaa gatcttactc   1920

agagatttga agaaaagctg caggaactag aaagtgtttc cagggatccc agcaatgaga   1980

atcctaaact tgaagacctc tgcttcatct tacaagaaga gtaccactta aacccagaga   2040

caataacaat tctctttgtg aaaaccagag cacttgtgga cgctttaaaa aattggattg   2100

aaggaaatcc taaactcagt tttctaaaac ctggcatatt gactggacgt ggcaaaacaa   2160

atcagaacac aggaatgacc ctcccggcac agaagtgtat attggatgca ttcaaagcca   2220

gtggagatca caatattctg attgccacct cagttgctga tgaaggcatt gacattgcac   2280

agtgcaatct tgtcatcctt tatgagtatg tgggcaatgt catcaaaatg atccaaacca   2340

gaggcagagg aagagcaaga ggtagcaagt gcttccttct gactagtaat gctggtgtaa   2400

ttgaaaaaga acaaataaac atgtacaaag aaaaaatgat gaatgactct attttacgcc   2460

ttcagacatg ggacgaagca gtatttaggg aaaagattct gcatatacag actcatgaaa   2520

aattcatcag agatagtcaa gaaaaaccaa aacctgtacc tgataaggaa aataaaaaac   2580

tgctctgcag aaagtgcaaa gccttggcat gttacacagc tgacgtaaga gtgatagagg   2640

aatgccatta cactgtgctt ggagatgctt ttaaggaatg ctttgtgagt agaccacatc   2700

ccaagccaaa gcagttttca agttttgaaa aaagagcaaa gatattctgt gcccgacaga   2760

actgcagcca tgactgggga atccatgtga agtacaagac atttgagatt ccagttataa   2820

aaattgaaag ttttgtggtg gaggatattg caactggagt tcagacactg tactcgaagt   2880

ggaaggactt tcattttgag aagataccat ttgatccagc agaaatgtcc aaatgatatc   2940

aggtcctcaa tcttcagcta cagggaatga gtaactttga gtggagaaga aacaaacata   3000

gtgggtataa tcatggatcg cttgtacccc tgtgaaaata tattttttaa aaatatcttt   3060

agcagtttgt actatattat atatgcaaag cacaaatgag tgaatcacag cactgagtat   3120

tttgtaggcc aacagagctc atagtacttg ggaaaaatta aaaagcctca tttctagcct   3180

tctttttaga gtcaactgcc aacaaacaca cagtaatcac tctgtacaca ctgggataga   3240

tgaatgaatg gaatgttggg aatttttatc tccctttgtc tccttaacct actgtaaact   3300

ggcttttgcc cttaacaatc tactgaaatt gttcttttga aggttaccag tgactctggt   3360

tgccaaatcc actgggcact tcttaacctt ctatttgacc tctgcgcatt tggccctgtt   3420

gagcactctt cttgaagctc tccctgggct tctctctctt ctagttctat tctagtcttt   3480

ttttattgag tcctcctctt tgctgatccc ttccaagggt tcaatatata tacatgtata   3540

tactgtacat atgtatatgt aactaatata catacataca ggtatgtata tgtaatggtt   3600

atatgtactc atgttcctgg tgtagcaacg tgtggtatgg ctacacagag aacatgagaa   3660

cataaagcca tttttatgct tactactaaa agctgtccac tgtagagttg ctgtatgtag   3720

caatgtgtat ccactctaca gtggtcagct tttagtagag agcataaaaa tgataaaata   3780

cttcttgaaa acttagttta ctatacatct tgccctatta atatgttctc ttaacgtgtg   3840

ccattgttct ctttgaccat tttcctataa tgatgttgat gttcaacacc tggactgaat   3900

gtctgttctc agatcccttg gatgttacag atgaggcagt ctgactgtcc tttctacttg   3960

aaagattaga atatgtatcc aaatggcatt cacgtgtcac ttagcaaggt ttgctgatgc   4020

ttcaaagagc ttagtttgcg gtttcctgga cgtggaaaca agtatctgag ttccctggag   4080

atcaacggga tgaggtgtta cagctgcctc cctcttcatg caatctggtg agcagtggtg   4140

caggcgggga gccagagaaa cttgccagtt atataacttc tctttggctt ttcttcatct   4200

gtaaaacaag gataatactg aactgtaagg gttagtggag agtttttaat taaaagaatg   4260

tgtgaaaagt acatgacaca gtagttgctt gataatagtt actagtagta gtattcttac   4320

taagacccaa tacaaatgga ttatttaaac caagtttatg agttggtttt ttttcatttt   4380

ctatttgtat tttattaaga gtgtcttttc ttatgtgatt ttttttaatt gctatttgat   4440

atggtttggc tatatgtccc cacccaaatc tcatcttgaa ttataatccc catgtgtcaa   4500

gggagggacc tgacgggagg tgattggatc acgggggcag ttgtccccat gctgttcttg   4560

ggatagtgag ttagttctca tgagatctga tggttttata agtgtttgac aattcctcct   4620

ttacacacac tctctctctc atctgctgcc atgtaagact tgcctgcttc cccttctgcc   4680

atgattgtaa gtttcctgag gcctcctcag ccatgtggaa ctgtgaatct attaagcctc   4740

ttttctttat aaatgaaaa                                                4759


<210>  184
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Thr Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile 
1               5                   10                  15      


Arg Lys Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp 
            20                  25                  30          


Phe Arg Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys 
        35                  40                  45              


Gly Pro Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu 
    50                  55                  60                  


Gln Glu Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala 
65                  70                  75                  80  


Gly Tyr Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys 
                85                  90                  95      


Ile Glu Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro 
            100                 105                 110         


Glu Phe Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser 
        115                 120                 125             


Glu Cys Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser 
    130                 135                 140                 


Thr Lys Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu 
145                 150                 155                 160 


Arg Ser Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu 
                165                 170                 175     


Lys Glu Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile 
            180                 185                 190         


Lys Asp Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp 
        195                 200                 205             


Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn Leu Ser Glu 
    210                 215                 220                 


Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr Asn Leu Tyr Ser Pro 
225                 230                 235                 240 


Phe Lys Pro Arg Asn Tyr Gln Leu Glu Leu Ala Leu Pro Ala Met Lys 
                245                 250                 255     


Gly Lys Asn Thr Ile Ile Cys Ala Pro Thr Gly Cys Gly Lys Thr Phe 
            260                 265                 270         


Val Ser Leu Leu Ile Cys Glu His His Leu Lys Lys Phe Pro Gln Gly 
        275                 280                 285             


Gln Lys Gly Lys Val Val Phe Phe Ala Asn Gln Ile Pro Val Tyr Glu 
    290                 295                 300                 


Gln Gln Lys Ser Val Phe Ser Lys Tyr Phe Glu Arg His Gly Tyr Arg 
305                 310                 315                 320 


Val Thr Gly Ile Ser Gly Ala Thr Ala Glu Asn Val Pro Val Glu Gln 
                325                 330                 335     


Ile Val Glu Asn Asn Asp Ile Ile Ile Leu Thr Pro Gln Ile Leu Val 
            340                 345                 350         


Asn Asn Leu Lys Lys Gly Thr Ile Pro Ser Leu Ser Ile Phe Thr Leu 
        355                 360                 365             


Met Ile Phe Asp Glu Cys His Asn Thr Ser Lys Gln His Pro Tyr Asn 
    370                 375                 380                 


Met Ile Met Phe Asn Tyr Leu Asp Gln Lys Leu Gly Gly Ser Ser Gly 
385                 390                 395                 400 


Pro Leu Pro Gln Val Ile Gly Leu Thr Ala Ser Val Gly Val Gly Asp 
                405                 410                 415     


Ala Lys Asn Thr Asp Glu Ala Leu Asp Tyr Ile Cys Lys Leu Cys Ala 
            420                 425                 430         


Ser Leu Asp Ala Ser Val Ile Ala Thr Val Lys His Asn Leu Glu Glu 
        435                 440                 445             


Leu Glu Gln Val Val Tyr Lys Pro Gln Lys Phe Phe Arg Lys Val Glu 
    450                 455                 460                 


Ser Arg Ile Ser Asp Lys Phe Lys Tyr Ile Ile Ala Gln Leu Met Arg 
465                 470                 475                 480 


Asp Thr Glu Ser Leu Ala Lys Arg Ile Cys Lys Asp Leu Glu Asn Leu 
                485                 490                 495     


Ser Gln Ile Gln Asn Arg Glu Phe Gly Thr Gln Lys Tyr Glu Gln Trp 
            500                 505                 510         


Ile Val Thr Val Gln Lys Ala Cys Met Val Phe Gln Met Pro Asp Lys 
        515                 520                 525             


Asp Glu Glu Ser Arg Ile Cys Lys Ala Leu Phe Leu Tyr Thr Ser His 
    530                 535                 540                 


Leu Arg Lys Tyr Asn Asp Ala Leu Ile Ile Ser Glu His Ala Arg Met 
545                 550                 555                 560 


Lys Asp Ala Leu Asp Tyr Leu Lys Asp Phe Phe Ser Asn Val Arg Ala 
                565                 570                 575     


Ala Gly Phe Asp Glu Ile Glu Gln Asp Leu Thr Gln Arg Phe Glu Glu 
            580                 585                 590         


Lys Leu Gln Glu Leu Glu Ser Val Ser Arg Asp Pro Ser Asn Glu Asn 
        595                 600                 605             


Pro Lys Leu Glu Asp Leu Cys Phe Ile Leu Gln Glu Glu Tyr His Leu 
    610                 615                 620                 


Asn Pro Glu Thr Ile Thr Ile Leu Phe Val Lys Thr Arg Ala Leu Val 
625                 630                 635                 640 


Asp Ala Leu Lys Asn Trp Ile Glu Gly Asn Pro Lys Leu Ser Phe Leu 
                645                 650                 655     


Lys Pro Gly Ile Leu Thr Gly Arg Gly Lys Thr Asn Gln Asn Thr Gly 
            660                 665                 670         


Met Thr Leu Pro Ala Gln Lys Cys Ile Leu Asp Ala Phe Lys Ala Ser 
        675                 680                 685             


Gly Asp His Asn Ile Leu Ile Ala Thr Ser Val Ala Asp Glu Gly Ile 
    690                 695                 700                 


Asp Ile Ala Gln Cys Asn Leu Val Ile Leu Tyr Glu Tyr Val Gly Asn 
705                 710                 715                 720 


Val Ile Lys Met Ile Gln Thr Arg Gly Arg Gly Arg Ala Arg Gly Ser 
                725                 730                 735     


Lys Cys Phe Leu Leu Thr Ser Asn Ala Gly Val Ile Glu Lys Glu Gln 
            740                 745                 750         


Ile Asn Met Tyr Lys Glu Lys Met Met Asn Asp Ser Ile Leu Arg Leu 
        755                 760                 765             


Gln Thr Trp Asp Glu Ala Val Phe Arg Glu Lys Ile Leu His Ile Gln 
    770                 775                 780                 


Thr His Glu Lys Phe Ile Arg Asp Ser Gln Glu Lys Pro Lys Pro Val 
785                 790                 795                 800 


Pro Asp Lys Glu Asn Lys Lys Leu Leu Cys Arg Lys Cys Lys Ala Leu 
                805                 810                 815     


Ala Cys Tyr Thr Ala Asp Val Arg Val Ile Glu Glu Cys His Tyr Thr 
            820                 825                 830         


Val Leu Gly Asp Ala Phe Lys Glu Cys Phe Val Ser Arg Pro His Pro 
        835                 840                 845             


Lys Pro Lys Gln Phe Ser Ser Phe Glu Lys Arg Ala Lys Ile Phe Cys 
    850                 855                 860                 


Ala Arg Gln Asn Cys Ser His Asp Trp Gly Ile His Val Lys Tyr Lys 
865                 870                 875                 880 


Thr Phe Glu Ile Pro Val Ile Lys Ile Glu Ser Phe Val Val Glu Asp 
                885                 890                 895     


Ile Ala Thr Gly Val Gln Thr Leu Tyr Ser Lys Trp Lys Asp Phe His 
            900                 905                 910         


Phe Glu Lys Ile Pro Phe Asp Pro Ala Glu Met Ser Lys 
        915                 920                 925 


<210>  185
<211>  3547
<212>  DNA
<213>  Homo sapiens

<400>  185
gcactcgccc ggctcgcccg ctttcgcacc cagttcacgc gccacagcta tgtgtccccg     60

agccgcgcgg gcgcccgcga cgctactcct cgccctgggc gcggtgctgt ggcctgcggc    120

tggcgcctgg gagcttacga ttttgcacac caacgacgtg cacagccggc tggagcagac    180

cagcgaggac tccagcaagt gcgtcaacgc cagccgctgc atgggtggcg tggctcggct    240

cttcaccaag gttcagcaga tccgccgcgc cgaacccaac gtgctgctgc tggacgccgg    300

cgaccagtac cagggcacta tctggttcac cgtgtacaag ggcgccgagg tggcgcactt    360

catgaacgcc ctgcgctacg atgccatggc actgggaaat catgaatttg ataatggtgt    420

ggaaggactg atcgagccac tcctcaaaga ggccaaattt ccaattctga gtgcaaacat    480

taaagcaaag gggccactag catctcaaat atcaggactt tatttgccat ataaagttct    540

tcctgttggt gatgaagttg tgggaatcgt tggatacact tccaaagaaa ccccttttct    600

ctcaaatcca gggacaaatt tagtgtttga agatgaaatc actgcattac aacctgaagt    660

agataagtta aaaactctaa atgtgaacaa aattattgca ctgggacatt cgggttttga    720

aatggataaa ctcatcgctc agaaagtgag gggtgtggac gtcgtggtgg gaggacactc    780

caacacattt ctttacacag gcaatccacc ttccaaagag gtgcctgctg ggaagtaccc    840

attcatagtc acttctgatg atgggcggaa ggttcctgta gtccaggcct atgcttttgg    900

caaataccta ggctatctga agatcgagtt tgatgaaaga ggaaacgtca tctcttccca    960

tggaaatccc attcttctaa acagcagcat tcctgaagat ccaagcataa aagcagacat   1020

taacaaatgg aggataaaat tggataatta ttctacccag gaattaggga aaacaattgt   1080

ctatctggat ggctcctctc aatcatgccg ctttagagaa tgcaacatgg gcaacctgat   1140

ttgtgatgca atgattaaca acaacctgag acacacggat gaaatgttct ggaaccacgt   1200

atccatgtgc attttaaatg gaggtggtat ccggtcgccc attgatgaac gcaacaatgg   1260

cacaattacc tgggagaacc tggctgctgt attgcccttt ggaggcacat ttgacctagt   1320

ccagttaaaa ggttccaccc tgaagaaggc ctttgagcat agcgtgcacc gctacggcca   1380

gtccactgga gagttcctgc aggtgggcgg aatccatgtg gtgtatgatc tttcccgaaa   1440

acctggagac agagtagtca aattagatgt tctttgcacc aagtgtcgag tgcccagtta   1500

tgaccctctc aaaatggacg aggtatataa ggtgatcctc ccaaacttcc tggccaatgg   1560

tggagatggg ttccagatga taaaagatga attattaaga catgactctg gtgaccaaga   1620

tatcaacgtg gtttctacat atatctccaa aatgaaagta atttatccag cagttgaagg   1680

tcggatcaag ttttccacag gaagtcactg ccatggaagc ttttctttaa tatttctttc   1740

actttgggca gtgatctttg ttttatacca atagccaaaa attctccttg cctttaatgt   1800

gtgaaactgc attttttcaa gtgagattca aatctgcctt ttaggacctg gctttgtgac   1860

agcaaaaacc atctttacag gctcctagaa gctgaaggtt agagcattat aaaatgaaga   1920

gacagacatg attactcagg gtcagcaacc tagtgagtta gaaaaaaaat taacataggg   1980

ccctataagg agaaagccaa ctatgttaag tttacgtgtc caaattttaa tgaaatttta   2040

ctaacaattt taaaccatat ttttcttctt catatccatt tctaatccat caaacagctt   2100

atgtttacat aaaattttat cattcacaag gaagttttaa gcacactgtc tcatttgata   2160

tccacaactt atttttggta ggaaagagag atgtttttcc cacctgtcag atgaaaaaac   2220

tgaagctcaa aaagggttga cttgaccata cagctaatgc tgacagatcc aagacctaga   2280

cctaggtctt ttgaactcaa gtccagcatt ctcaactata tcaagttact gttcagaata   2340

cttaatatct cctctcttca taattatcaa tagccccaag ctcatggatg acaaatctct   2400

gctttatttc ttgtctctat tttttcactt tatagctcct gttataatag caagtttaat   2460

ggtataaaca caggatacca tcctctcttg caacacccat gtgcctttga tgagtcaggt   2520

agcaagctgt agtagataat gagaaaggcc agaggctgca aagacagtca aaggacacga   2580

gagaaaggaa ggggaagaac aggactccag gactgtttta tattatagaa aagcaagagc   2640

taaagagcat ttacacatgt taaacagata cttgttaagc atagtgcctg acacacggca   2700

ttagctgtta ttttatgaga ttccatcagc tctgcctctg tcctctttct tctaacatga   2760

aggtatcatg agaagagaac cttctaacat aagctgtaat tctaaacctg cacttgtccc   2820

tctccagcaa gaggctagca ctgaattcat tctactcata ctacacaccc agttatggaa   2880

tgtccagagt tctcgaagaa aataaatgac tttaggaaga ggtatacatt ttttaagtcg   2940

ctctgcctcc aaatctgaac agtcactgta aatcattctt aagcccagat atgagaactt   3000

ctgctggaaa gtgggaccct ctgagtgggt ggtcagaaaa tacccatgct gatgaaatga   3060

cctatgccca aagaacaaat acttaacgtg ggagtggaac cacatgagcc tgctcagctc   3120

tgcataagta attcaagaaa tgggaggctt caccttaaaa acagtgtgca aatggcagct   3180

agaggttttg ataggaagta tgtttgtttc ttagtgttta caaatattaa gtactcttga   3240

tacaaaatat acttttaaac ttcataacct ttttataaaa gttgttgcag caaaataata   3300

gcctcggttc tatgcatata tggattgcta taaaaaatgt caataagatt gtacaaggaa   3360

aattagagaa agtcacattt agggtttatt ttttacactt ggccagtaaa atagggtaaa   3420

tcctattaga aattttttaa agaacttttt ttaagtttcc taaatctgtg tgtgtattgt   3480

gaagtggtat aagaaatgac tttgaaccac tttgcaattg tagattccca acaataaaat   3540

tgaagat                                                             3547


<210>  186
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 
            20                  25                  30          


His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 
        35                  40                  45              


Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 
    50                  55                  60                  


Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 
65                  70                  75                  80  


Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 
                85                  90                  95      


Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 
            100                 105                 110         


Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 
        115                 120                 125             


Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 
    130                 135                 140                 


Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 
145                 150                 155                 160 


Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 
                165                 170                 175     


Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 
            180                 185                 190         


Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 
        195                 200                 205             


Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 
    210                 215                 220                 


Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 
225                 230                 235                 240 


Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 
                245                 250                 255     


Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 
            260                 265                 270         


Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 
        275                 280                 285             


Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 
    290                 295                 300                 


Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 
305                 310                 315                 320 


Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 
                325                 330                 335     


Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 
            340                 345                 350         


Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 
        355                 360                 365             


Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val 
    370                 375                 380                 


Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 
385                 390                 395                 400 


Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro 
                405                 410                 415     


Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys 
            420                 425                 430         


Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu 
        435                 440                 445             


Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys 
    450                 455                 460                 


Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg 
465                 470                 475                 480 


Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile 
                485                 490                 495     


Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys 
            500                 505                 510         


Asp Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val 
        515                 520                 525             


Ser Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly 
    530                 535                 540                 


Arg Ile Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu 
545                 550                 555                 560 


Ile Phe Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln 
                565                 570                 


<210>  187
<211>  2210
<212>  DNA
<213>  Homo sapiens

<400>  187
agccgcggcc tcaactaaaa gtggccattg acctttcaag ctttcgagca gtgatgcaat     60

agaatagtat ttcaaagaaa aatgcttatc gaaattttgg atccggtttt cccgtgattg    120

ttaagggttt cttttaaaaa gtaggtcaca tttcaagtag gtcatatttc gggggcgggt    180

gcgcagacaa ggagatgagt ttccactaag gccagggggc ctccaacggg gttggaggtg    240

agaatcccag gtagggtaga ggtgccgaga tccttccgaa tcccagccct ggggcgtcag    300

ccctgcaggg aatggcagag acactctccg gactgaggga accgaggcca gtcaccaagc    360

cccttccggg cgcgcaggcg atcagtgggt gaccgcggct gcgagggact ttgtcatccg    420

tcctccagga tctggggaga aagagcccca tcccttctct ctctgccacc atttcggaca    480

ccccgcaggg actcgttttg ggattcgcac tgacttcaag gaaggacgcg aacccttctc    540

tgaccccagc tcgggcggcc acctgtcttt gccgcggtga cccttctctc atgaccctgc    600

ggtgccttga gccctccggg aatggcgggg aagggacgcg gagccagtgg gggaccgcgg    660

ggtcggcgga ggagccatcc ccgcaggcgg cgcgtctggc gaaggccctg cgggagctcg    720

gtcagacagg atggtactgg ggaagtatga ctgttaatga agccaaagag aaattaaaag    780

aggcaccaga aggaactttc ttgattagag atagctcgca ttcagactac ctactaacaa    840

tatctgttaa aacatcagct ggaccaacta atcttcgaat cgaataccaa gacggaaaat    900

tcagattgga ctctatcata tgtgtcaaat ccaagcttaa acaatttgac agtgtggttc    960

atctgatcga ctactatgtt cagatgtgca aggataagcg gacaggtcca gaagcccccc   1020

ggaacggcac tgttcacctt tatctgacca aaccgctcta cacgtcagca ccatctctgc   1080

agcatctctg taggctcacc attaacaaat gtaccggtgc catctgggga ctgcctttac   1140

caacaagact aaaagattac ttggaagaat ataaattcca ggtataaatg tttctctttt   1200

tttaaacatg tctcacatag agtatctccg aatgcagcta tgtaaaagag aaccaaaact   1260

tgagtgctct ggataactat atggaatgct ttctaagaac agctgaagct aatctaattt   1320

aaatttaaca gcttgaagag gtagctaggt gtttaaagtt cctccagata cttttacctg   1380

agtgatgctt cccttcctaa ggctgaccaa gacctgttga tccttttaga ttaaaaataa   1440

aatgtcgcat gtaaaggctg aagtcgcgtt ttatcagaat gccttgcctt cttaggttct   1500

tttccattat gtcaaaggtc caggctccag taggagagaa agaactcctc ataggaatac   1560

tgaagaagtg ggaaggaacc aagctgacac aggcctcact gcaatttgat atgcctgctg   1620

atcagagtct cttgggcatt ttatattttg cattctgatg tacctaggag ttttgttaaa   1680

cagatgatgt atgtgagtat ttatcccatt ttatgcaatt aaccaaatca accaaaaaaa   1740

gtgaccatga agtcctgtat ttgtcttttt actacatgta ggaactctca tgtgaatgag   1800

tactgtagta atccattcta tgggagcctt atttcagaaa tatttcaaac tggtgcaaat   1860

ggaaaagact ttctcttttc ctttaaagct aaagacaaga atatcatgct atacaggtgc   1920

aactcaatcc ccgttaataa aaaccaatgt aggtataggc attctaccct ttgaaatagc   1980

tgtgtcccaa cctgttgcca ttgatttttt ggaaatggct ttagaaatat ccaagttgtc   2040

cttgaattgt ctaaccatgg acataaacag ttgtctccct tctactgtgt agaatacttt   2100

gacttaattt tcttccagat acagggggat acctgcctgt ttttcaaagt gtttatttac   2160

tgctgttact atttgattag aatgtattaa ataaaaaaaa cctgatttct              2210


<210>  188
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys Thr Gly 
                165                 170                 175     


Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu 
            180                 185                 190         


Glu Tyr Lys Phe Gln Val 
        195             


<210>  189
<211>  1596
<212>  DNA
<213>  Homo sapiens

<400>  189
ccgcgggacg catgcgcacg gcggacggag gcgagccggc cggggcttcc tccccggccg     60

gcagggtgga cggtgggctc cagatgggat cagagcggat ggagatgcgg aagcggcaga    120

tgcccgccgc ccaggacaca ccaggcgccg ccccaggcca gcccggagcg gggagtcgcg    180

ggtccaacgc atgctgcttc tgctggtgct gctgttgtag ctgctcgtgt ctcactgtta    240

gaaaccagga agatcagagg cccacaatag cttcccacga actcagagca gatcttccaa    300

cctgggaaga aagccctgct cctactctgg aagaagtcaa cgcctgggct cagtcatttg    360

acaaattaat ggtcactcca gcaggaagga atgcattccg tgaattcctc cgaacagaat    420

tcagtgagga aaatatgctc ttctggatgg cctgtgagga actgaaaaag gaagctaata    480

aaaacattat tgaagagaaa gcaaggataa tctatgaaga ctacatttct atactttctc    540

ctaaggaggt gagcttagac tcccgggtga gagaagtgat caacagaaac atggtggagc    600

catcccaaca catattcgat gatgctcaac ttcagattta caccctgatg cacagagact    660

catatcctcg attcatgaac tctgctgtct ataaggactt gcttcagtcc ttatcggaga    720

aatctattga agcataggat ttttcaaata tatttattat taataaaata ataaaagaat    780

tcatgggcta caactagcac agggaattta gaggttgtag catcttctgc tggagtaata    840

ctcaggctat tctaataaca gatgattcct tcaacagact gctatatatt caccatgtaa    900

actgcagcca cctttagtga tacttttaaa aaaaaaaata aagggatatg gctgttgtag    960

aaagatagcg tatttgcatt tacaataaca gtagcatgtt gtcagtggcc aaggctacac   1020

agaaggctcc ctgctgcccg gagcaggtac atccacagag caaagggaac cacttttatt   1080

ttgcatgagt ttggtaactg attactctcc cctcaaagaa aagacattca ggtgtttctc   1140

aacgacatct tctgtccagc aagctcggtt tgaatacgtc acttaccagt gccattgcag   1200

gacccaaatt cacagttcat aaaagatgtg accactacat gtaaaaatag cattctactt   1260

gatcttacag tatgtatgta tgtatgtatg gagacatatg tgtgcgtgtg gatgtctaca   1320

tggttaatgg aaagcactgt gctctgaagt ggatcagtct caagtgtctg gtaacagcag   1380

caatgcttag aaaattcttt tgttgaaaag agttactgtt attatcagaa tttgccaacc   1440

taaagaatga atttttaaat tcataacttg gtcatgttca caacaaaact gtcaaataag   1500

catatttcca tttttattac tgaaagaaat atgggcattt tcattcttta aagaaataaa   1560

gcacaagaat tttatctcaa aaaaaaaaaa aaaaaa                             1596


<210>  190
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Arg Thr Ala Asp Gly Gly Glu Pro Ala Gly Ala Ser Ser Pro Ala 
1               5                   10                  15      


Gly Arg Val Asp Gly Gly Leu Gln Met Gly Ser Glu Arg Met Glu Met 
            20                  25                  30          


Arg Lys Arg Gln Met Pro Ala Ala Gln Asp Thr Pro Gly Ala Ala Pro 
        35                  40                  45              


Gly Gln Pro Gly Ala Gly Ser Arg Gly Ser Asn Ala Cys Cys Phe Cys 
    50                  55                  60                  


Trp Cys Cys Cys Cys Ser Cys Ser Cys Leu Thr Val Arg Asn Gln Glu 
65                  70                  75                  80  


Asp Gln Arg Pro Thr Ile Ala Ser His Glu Leu Arg Ala Asp Leu Pro 
                85                  90                  95      


Thr Trp Glu Glu Ser Pro Ala Pro Thr Leu Glu Glu Val Asn Ala Trp 
            100                 105                 110         


Ala Gln Ser Phe Asp Lys Leu Met Val Thr Pro Ala Gly Arg Asn Ala 
        115                 120                 125             


Phe Arg Glu Phe Leu Arg Thr Glu Phe Ser Glu Glu Asn Met Leu Phe 
    130                 135                 140                 


Trp Met Ala Cys Glu Glu Leu Lys Lys Glu Ala Asn Lys Asn Ile Ile 
145                 150                 155                 160 


Glu Glu Lys Ala Arg Ile Ile Tyr Glu Asp Tyr Ile Ser Ile Leu Ser 
                165                 170                 175     


Pro Lys Glu Val Ser Leu Asp Ser Arg Val Arg Glu Val Ile Asn Arg 
            180                 185                 190         


Asn Met Val Glu Pro Ser Gln His Ile Phe Asp Asp Ala Gln Leu Gln 
        195                 200                 205             


Ile Tyr Thr Leu Met His Arg Asp Ser Tyr Pro Arg Phe Met Asn Ser 
    210                 215                 220                 


Ala Val Tyr Lys Asp Leu Leu Gln Ser Leu Ser Glu Lys Ser Ile Glu 
225                 230                 235                 240 


Ala 
    


<210>  191
<211>  1904
<212>  DNA
<213>  Homo sapiens

<400>  191
agctatttca aggcgcgcgc ctcgtggtgg actcaccgct agcccgcagc gctcggcttc     60

ctggtaattc ttcacctctt ttctcagctc cctgcagcat gggtgctggg ccctccttgc    120

tgctcgccgc cctcctgctg cttctctccg gcgacggcgc cgtgcgctgc gacacacctg    180

ccaactgcac ctatcttgac ctgctgggca cctgggtctt ccaggtgggc tccagcggtt    240

cccagcgcga tgtcaactgc tcggttatgg gaccacaaga aaaaaaagta gtggtgtacc    300

ttcagaagct ggatacagca tatgatgacc ttggcaattc tggccatttc accatcattt    360

acaaccaagg ctttgagatt gtgttgaatg actacaagtg gtttgccttt tttaagtata    420

aagaagaggg cagcaaggtg accacttact gcaacgagac aatgactggg tgggtgcatg    480

atgtgttggg ccggaactgg gcttgtttca ccggaaagaa ggtgggaact gcctctgaga    540

atgtgtatgt caacacagca caccttaaga attctcagga aaagtattct aataggctct    600

acaagtatga tcacaacttt gtgaaagcta tcaatgccat tcagaagtct tggactgcaa    660

ctacatacat ggaatatgag actcttaccc tgggagatat gattaggaga agtggtggcc    720

acagtcgaaa aatcccaagg cccaaacctg caccactgac tgctgaaata cagcaaaaga    780

ttttgcattt gccaacatct tgggactgga gaaatgttca tggtatcaat tttgtcagtc    840

ctgttcgaaa ccaagcatcc tgtggcagct gctactcatt tgcttctatg ggtatgctag    900

aagcgagaat ccgtatacta accaacaatt ctcagacccc aatcctaagc cctcaggagg    960

ttgtgtcttg tagccagtat gctcaaggct gtgaaggcgg cttcccatac cttattgcag   1020

gaaagtacgc ccaagatttt gggctggtgg aagaagcttg cttcccctac acaggcactg   1080

attctccatg caaaatgaag gaagactgct ttcgttatta ctcctctgag taccactatg   1140

taggaggttt ctatggaggc tgcaatgaag ccctgatgaa gcttgagttg gtccatcatg   1200

ggcccatggc agttgctttt gaagtatatg atgacttcct ccactacaaa aaggggatct   1260

accaccacac tggtctaaga gaccctttca acccctttga gctgactaat catgctgttc   1320

tgcttgtggg ctatggcact gactcagcct ctgggatgga ttactggatt gttaaaaaca   1380

gctggggcac cggctggggt gagaatggct acttccggat ccgcagagga actgatgagt   1440

gtgcaattga gagcatagca gtggcagcca caccaattcc taaattgtag ggtatgcctt   1500

ccagtatttc ataatgatct gcatcagttg taaaggggaa ttggtatatt cacagactgt   1560

agactttcag cagcaatctc agaagcttac aaatagattt ccatgaagat atttgtcttc   1620

agaattaaaa ctgcccttaa ttttaatata cctttcaatc ggccactggc catttttttc   1680

taagtattca attaagtggg aattttctgg aagatggtca gctatgaagt aatagagttt   1740

gcttaatcat ttgtaattca aacatgctat attttttaaa atcaatgtga aaacatagac   1800

ttatttttaa attgtaccaa tcacaagaaa ataatggcaa taattatcaa aacttttaaa   1860

atagatgctc atatttttaa aataaagttt taaaaataac tgca                    1904


<210>  192
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr Lys Glu Glu Gly Ser 
            100                 105                 110         


Lys Val Thr Thr Tyr Cys Asn Glu Thr Met Thr Gly Trp Val His Asp 
        115                 120                 125             


Val Leu Gly Arg Asn Trp Ala Cys Phe Thr Gly Lys Lys Val Gly Thr 
    130                 135                 140                 


Ala Ser Glu Asn Val Tyr Val Asn Thr Ala His Leu Lys Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Tyr Ser Asn Arg Leu Tyr Lys Tyr Asp His Asn Phe Val Lys 
                165                 170                 175     


Ala Ile Asn Ala Ile Gln Lys Ser Trp Thr Ala Thr Thr Tyr Met Glu 
            180                 185                 190         


Tyr Glu Thr Leu Thr Leu Gly Asp Met Ile Arg Arg Ser Gly Gly His 
        195                 200                 205             


Ser Arg Lys Ile Pro Arg Pro Lys Pro Ala Pro Leu Thr Ala Glu Ile 
    210                 215                 220                 


Gln Gln Lys Ile Leu His Leu Pro Thr Ser Trp Asp Trp Arg Asn Val 
225                 230                 235                 240 


His Gly Ile Asn Phe Val Ser Pro Val Arg Asn Gln Ala Ser Cys Gly 
                245                 250                 255     


Ser Cys Tyr Ser Phe Ala Ser Met Gly Met Leu Glu Ala Arg Ile Arg 
            260                 265                 270         


Ile Leu Thr Asn Asn Ser Gln Thr Pro Ile Leu Ser Pro Gln Glu Val 
        275                 280                 285             


Val Ser Cys Ser Gln Tyr Ala Gln Gly Cys Glu Gly Gly Phe Pro Tyr 
    290                 295                 300                 


Leu Ile Ala Gly Lys Tyr Ala Gln Asp Phe Gly Leu Val Glu Glu Ala 
305                 310                 315                 320 


Cys Phe Pro Tyr Thr Gly Thr Asp Ser Pro Cys Lys Met Lys Glu Asp 
                325                 330                 335     


Cys Phe Arg Tyr Tyr Ser Ser Glu Tyr His Tyr Val Gly Gly Phe Tyr 
            340                 345                 350         


Gly Gly Cys Asn Glu Ala Leu Met Lys Leu Glu Leu Val His His Gly 
        355                 360                 365             


Pro Met Ala Val Ala Phe Glu Val Tyr Asp Asp Phe Leu His Tyr Lys 
    370                 375                 380                 


Lys Gly Ile Tyr His His Thr Gly Leu Arg Asp Pro Phe Asn Pro Phe 
385                 390                 395                 400 


Glu Leu Thr Asn His Ala Val Leu Leu Val Gly Tyr Gly Thr Asp Ser 
                405                 410                 415     


Ala Ser Gly Met Asp Tyr Trp Ile Val Lys Asn Ser Trp Gly Thr Gly 
            420                 425                 430         


Trp Gly Glu Asn Gly Tyr Phe Arg Ile Arg Arg Gly Thr Asp Glu Cys 
        435                 440                 445             


Ala Ile Glu Ser Ile Ala Val Ala Ala Thr Pro Ile Pro Lys Leu 
    450                 455                 460             


<210>  193
<211>  4879
<212>  DNA
<213>  Homo sapiens

<400>  193
gagggaagcg gctagaggat cggggagaag gagcattcgc cggaggctgg aggaggctga     60

cccgcgtccc cgcccagcct gctcctatgc ggtacttgaa ggatggcgaa gaggtcgcgc    120

agtgaggatg aggatgatga ccttcagtat gccgatcatg attatgaagt accacaacaa    180

aaaggactga agaaactctg gaacagagta aaatggacaa gggacgagga tgataaatta    240

aagaagttgg ttgaacaaca tggaactgat gattggactc taattgctag tcatcttcaa    300

aatcgctctg attttcagtg ccagcatcga tggcagaaag ttttaaatcc tgaattgata    360

aagggtcctt ggactaaaga agaagatcag agggttattg aattagttca gaaatatggg    420

ccaaaaagat ggtctttaat tgcaaaacat ttaaaaggaa gaataggcaa gcagtgtaga    480

gaaagatggc ataatcatct gaatcctgag gtaaagaaat cttcctggac agaagaggag    540

gacaggatca tctatgaagc acataagcgg ttgggaaatc gttgggcaga aattgccaaa    600

ctacttccag gaaggactga taattctatc aaaaatcatt ggaattctac tatgcgaaga    660

aaagtggaac aggagggcta tttacaagat ggaataaaat cagaacgatc ttcatctaaa    720

cttcaacaca aaccttgtgc agctatggat catatgcaaa cccagaatca gttttacata    780

cctgttcaga tccctgggta tcagtatgtg tcacctgaag gcaattgtat agaacatgtt    840

cagcctactt ctgcctttat tcagcaaccc ttcattgatg aagatcctga taaggaaaag    900

aaaataaagg aacttgagat gcttcttatg tcagctgaga atgaagttag aagaaagcga    960

attccatcac agcctggaag tttttctagc tggtctggta gtttcctcat ggatgataac   1020

atgtctaata ctctaaatag ccttgacgag cacactagtg agttttacag tatggatgaa   1080

aatcagcctg tgtctgctca gcagaattca cccacaaagt tcctggccgt ggaggcaaac   1140

gctgtgttat cctctttgca gaccatccca gaatttgcag agactctaga acttattgaa   1200

tctgatcctg tagcatggag tgacgttacc agttttgata tttctgatgc tgctgcttct   1260

cctatcaaat ccaccccagt taaattaatg agaattcagc acaatgaagg agccatggaa   1320

tgccaattta acgtcagtct tgtacttgaa gggaaaaaaa acacttgtaa tggtggcaac   1380

agtgaagctg ttcctttaac atccccaaat atagccaagt ttagcactcc accagccatc   1440

ctcagaaaga agagaaaaat gcgagtgggt cattccccag gcagcgaact tagggatggc   1500

tcattgaacg atggtggtaa tatggcgcta aaacatacac cactgaaaac actaccattt   1560

tctccttcac agtttttcaa cacatgtcct ggtaatgaac aacttaatat agaaaatcct   1620

tcatttacat caacccctat ttgtgggcag aaagctctca ttacaactcc tcttcataag   1680

gaaacaactc ccaaagatca aaaggaaaat gtagggttta gaacacctac tattagaaga   1740

tctatactgg gtaccacacc aagaactcct actcctttta agaatgcgct tgctgctcag   1800

gagaaaaaat atggacctct taaaattgtg tcccagccac ttgctttctt ggaagaagat   1860

attcgggaag ttttaaaaga agaaactgga acagacctat tcctcaaaga ggaagatgaa   1920

cctgcttaca aaagctgcaa acaagagaat accgcttctg ggaagaaagt cagaaaatca   1980

ctagtcttag ataattggga aaaagaagaa tcaggcactc aactgttgac tgaagacatt   2040

tcagacatgc agtcagaaaa tagatttact acatccttat taatgatacc attattggaa   2100

atacatgaca ataggtgcaa cttgattcct gaaaaacaag atataaattc aaccaacaaa   2160

acatatacac ttactaaaaa gaaaccaaac cctaacactt ccaaagttgt caaattggaa   2220

aagaatcttc agtcaaattg tgaatgggaa acagtggttt atgggaagac agaagaccaa   2280

cttattatga ctgaacaagc aagaagatat ctgagtactt acacagctac cagtagtact   2340

tcaagagctc tcatactgta attgttatta aaattgatga aatgccccac tcccttactg   2400

cagtctctac taaattaggt tgcagtgaaa tttttctcaa ttagttgttt ttaaagttgt   2460

aagatagccc ttttaataca gcatcttttt tctattctat atagtaggca gaaagctagt   2520

aagtcactta aggggtagat agtttcatag tttatttttt aagagatgag atttttaaaa   2580

attgttttta aagaacaaga tgggaaaata atagaatgtt catggatttc taaaagtaaa   2640

ttctcatata ttttcttcac aagatatatg ttgctactct cttgatgctg cagttttgtt   2700

atagataggt gtatgagtat atatgatttc tgaaattagt ctatgtatgg aaagcacaca   2760

tgattttatg aagtactttt gcccatgtgc tgatttactt aggctaccat ttacaaagaa   2820

acacattgaa aaggaattta aaggaaggat agaaagttgc actactaatt ttttgttttt   2880

tttttcagaa gcagtaaaat taactacagt gttaaatgta tttatttgag catagtactg   2940

aaaacaaaaa gcattcaaaa aagagttttt tctttattag taaatagtat tttcttaatc   3000

tcagaggagc tgagagtttt gttgaatgta ttgtacagta tgtaggagca ggagaacttt   3060

gtaaattgga aagaagtctg tttttataat ttatttttat ttttaaagct taaatgtaga   3120

tatttatacg tatacagggt gcctagaagc caatgttgtt tcctgttatt acagctaaca   3180

cagtaaagaa taattttgac tttaagtatg aaacagtagt aagttatagc tgcaaagaat   3240

acaatatcta tactgtatgt cacatctacc taaatgttgc actatgccct ttaaatcatg   3300

ctggttataa agtagttcta aaaatgtact aaataataat ttaatatttt ctttttaaat   3360

tatatcgggg gtggtcatat acattaatct ggtgatttgt atatgtgttt gaaatttttg   3420

cattttgttt aaaaaataat atggtacctt ggtccctaaa aacagtctgc acttagaagt   3480

ttatatttac tcagtgtttc agaagtggag aacattatct tttatttata aaaatatttt   3540

gtcctttttt aaatgttttg tgtttctcta caggttacaa cagttgcttc agttgcctgt   3600

tttaggtgtt tgcacttatt ttatttcttc ttgaaagaat ttttatttgc ttttgtggta   3660

gagattatat gtaatttttt ttcagtcata taatggtgtg ctgtcaactt aaacactgac   3720

aggtaaatag aattgtacac tgtagtttga attatttata attgacacac tctctccctc   3780

tccactcctg aagtatgctg ctatagaaaa tagcagaatc ggcttgctgc tacgagagaa   3840

ggaaagagcg accaccactt gcactgtgtg aaaagataaa aaacaaatga tggcaagttc   3900

tcaagttaac taaatggaat caaccattac caggcaaatt cttgcaaata ccaaaatact   3960

actatgcctt ataaaacaaa atgaaagcag gttaagattt tctgctctgt ttgtatgtta   4020

atagaaatgg aaatactaag tattttaatg cttagctctt gaacagtaga cctaaaaggg   4080

ttttaagcta tttaaatcta cttgctagtt tttgcatatt ttatatatat atatatttat   4140

atatatatat agtgagaagt gaagaaaatg tatggtacta agattatgcc ttattgataa   4200

atagataaac caatttgaat cctcttagca tgtttaagta tgttgattgc tttctaatta   4260

atgaacttct cacagaaatt tcacttagtg aaaccaatga ttgtagcaaa ctcatactgg   4320

atcatttcag ttaccttgaa ctaatagcac ataatggttt tttgttgttg ttgtttttaa   4380

tgtagccctt acctggatat acatagtctg caatcaccaa agtataatat cttgtaaggc   4440

tatatttttt aaagcatatt ttttcttgag cattaaatta tcctaaatgg taatatattg   4500

tggataagtc tgggcttatt ggacataata catatttggg ttggtactgg ttgaatcctt   4560

cagttaactg ctttgttgct ttttgcaaga ttttttatct taaacatgtc aggcatctta   4620

agtcaccttt atactgtttt gttcctctga gtttctttca gtatgttata caaatgccag   4680

acataacatg tagcagccat acttgcatgg aaactgacta cacatacata atactgcatt   4740

ttattgtaag gttttcacat taatacagca attaccctga ctaaattgag ttttgtgata   4800

tatggaaaac ttcattgtaa gagaatcttg catacaatgt tgacatatta acatccaaaa   4860

taaagcatct gtgtacaag                                                4879


<210>  194
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Ala Lys Arg Ser Arg Ser Glu Asp Glu Asp Asp Asp Leu Gln Tyr 
1               5                   10                  15      


Ala Asp His Asp Tyr Glu Val Pro Gln Gln Lys Gly Leu Lys Lys Leu 
            20                  25                  30          


Trp Asn Arg Val Lys Trp Thr Arg Asp Glu Asp Asp Lys Leu Lys Lys 
        35                  40                  45              


Leu Val Glu Gln His Gly Thr Asp Asp Trp Thr Leu Ile Ala Ser His 
    50                  55                  60                  


Leu Gln Asn Arg Ser Asp Phe Gln Cys Gln His Arg Trp Gln Lys Val 
65                  70                  75                  80  


Leu Asn Pro Glu Leu Ile Lys Gly Pro Trp Thr Lys Glu Glu Asp Gln 
                85                  90                  95      


Arg Val Ile Glu Leu Val Gln Lys Tyr Gly Pro Lys Arg Trp Ser Leu 
            100                 105                 110         


Ile Ala Lys His Leu Lys Gly Arg Ile Gly Lys Gln Cys Arg Glu Arg 
        115                 120                 125             


Trp His Asn His Leu Asn Pro Glu Val Lys Lys Ser Ser Trp Thr Glu 
    130                 135                 140                 


Glu Glu Asp Arg Ile Ile Tyr Glu Ala His Lys Arg Leu Gly Asn Arg 
145                 150                 155                 160 


Trp Ala Glu Ile Ala Lys Leu Leu Pro Gly Arg Thr Asp Asn Ser Ile 
                165                 170                 175     


Lys Asn His Trp Asn Ser Thr Met Arg Arg Lys Val Glu Gln Glu Gly 
            180                 185                 190         


Tyr Leu Gln Asp Gly Ile Lys Ser Glu Arg Ser Ser Ser Lys Leu Gln 
        195                 200                 205             


His Lys Pro Cys Ala Ala Met Asp His Met Gln Thr Gln Asn Gln Phe 
    210                 215                 220                 


Tyr Ile Pro Val Gln Ile Pro Gly Tyr Gln Tyr Val Ser Pro Glu Gly 
225                 230                 235                 240 


Asn Cys Ile Glu His Val Gln Pro Thr Ser Ala Phe Ile Gln Gln Pro 
                245                 250                 255     


Phe Ile Asp Glu Asp Pro Asp Lys Glu Lys Lys Ile Lys Glu Leu Glu 
            260                 265                 270         


Met Leu Leu Met Ser Ala Glu Asn Glu Val Arg Arg Lys Arg Ile Pro 
        275                 280                 285             


Ser Gln Pro Gly Ser Phe Ser Ser Trp Ser Gly Ser Phe Leu Met Asp 
    290                 295                 300                 


Asp Asn Met Ser Asn Thr Leu Asn Ser Leu Asp Glu His Thr Ser Glu 
305                 310                 315                 320 


Phe Tyr Ser Met Asp Glu Asn Gln Pro Val Ser Ala Gln Gln Asn Ser 
                325                 330                 335     


Pro Thr Lys Phe Leu Ala Val Glu Ala Asn Ala Val Leu Ser Ser Leu 
            340                 345                 350         


Gln Thr Ile Pro Glu Phe Ala Glu Thr Leu Glu Leu Ile Glu Ser Asp 
        355                 360                 365             


Pro Val Ala Trp Ser Asp Val Thr Ser Phe Asp Ile Ser Asp Ala Ala 
    370                 375                 380                 


Ala Ser Pro Ile Lys Ser Thr Pro Val Lys Leu Met Arg Ile Gln His 
385                 390                 395                 400 


Asn Glu Gly Ala Met Glu Cys Gln Phe Asn Val Ser Leu Val Leu Glu 
                405                 410                 415     


Gly Lys Lys Asn Thr Cys Asn Gly Gly Asn Ser Glu Ala Val Pro Leu 
            420                 425                 430         


Thr Ser Pro Asn Ile Ala Lys Phe Ser Thr Pro Pro Ala Ile Leu Arg 
        435                 440                 445             


Lys Lys Arg Lys Met Arg Val Gly His Ser Pro Gly Ser Glu Leu Arg 
    450                 455                 460                 


Asp Gly Ser Leu Asn Asp Gly Gly Asn Met Ala Leu Lys His Thr Pro 
465                 470                 475                 480 


Leu Lys Thr Leu Pro Phe Ser Pro Ser Gln Phe Phe Asn Thr Cys Pro 
                485                 490                 495     


Gly Asn Glu Gln Leu Asn Ile Glu Asn Pro Ser Phe Thr Ser Thr Pro 
            500                 505                 510         


Ile Cys Gly Gln Lys Ala Leu Ile Thr Thr Pro Leu His Lys Glu Thr 
        515                 520                 525             


Thr Pro Lys Asp Gln Lys Glu Asn Val Gly Phe Arg Thr Pro Thr Ile 
    530                 535                 540                 


Arg Arg Ser Ile Leu Gly Thr Thr Pro Arg Thr Pro Thr Pro Phe Lys 
545                 550                 555                 560 


Asn Ala Leu Ala Ala Gln Glu Lys Lys Tyr Gly Pro Leu Lys Ile Val 
                565                 570                 575     


Ser Gln Pro Leu Ala Phe Leu Glu Glu Asp Ile Arg Glu Val Leu Lys 
            580                 585                 590         


Glu Glu Thr Gly Thr Asp Leu Phe Leu Lys Glu Glu Asp Glu Pro Ala 
        595                 600                 605             


Tyr Lys Ser Cys Lys Gln Glu Asn Thr Ala Ser Gly Lys Lys Val Arg 
    610                 615                 620                 


Lys Ser Leu Val Leu Asp Asn Trp Glu Lys Glu Glu Ser Gly Thr Gln 
625                 630                 635                 640 


Leu Leu Thr Glu Asp Ile Ser Asp Met Gln Ser Glu Asn Arg Phe Thr 
                645                 650                 655     


Thr Ser Leu Leu Met Ile Pro Leu Leu Glu Ile His Asp Asn Arg Cys 
            660                 665                 670         


Asn Leu Ile Pro Glu Lys Gln Asp Ile Asn Ser Thr Asn Lys Thr Tyr 
        675                 680                 685             


Thr Leu Thr Lys Lys Lys Pro Asn Pro Asn Thr Ser Lys Val Val Lys 
    690                 695                 700                 


Leu Glu Lys Asn Leu Gln Ser Asn Cys Glu Trp Glu Thr Val Val Tyr 
705                 710                 715                 720 


Gly Lys Thr Glu Asp Gln Leu Ile Met Thr Glu Gln Ala Arg Arg Tyr 
                725                 730                 735     


Leu Ser Thr Tyr Thr Ala Thr Ser Ser Thr Ser Arg Ala Leu Ile Leu 
            740                 745                 750         


<210>  195
<211>  1498
<212>  DNA
<213>  Homo sapiens

<400>  195
accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc     60

ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg    120

atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag    180

atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga    240

atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg    300

gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc    360

accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag    420

gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa    480

aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat    540

atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa    600

atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat    660

gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg    720

gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc    780

cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga    840

gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga    900

gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag    960

ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg   1020

cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc   1080

agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc   1140

tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc   1200

tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt   1260

ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt   1320

aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt   1380

taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat   1440

atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaag     1498


<210>  196
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  197
<211>  980
<212>  DNA
<213>  Homo sapiens

<400>  197
gcggcggcgg gcagcagctg cgctgcgact gctctggaag gagaggacgg ggcacaaacc     60

ctgaccatga ccccccacag gctgctgcca ccgctgctgc tgctgctagc tctgctgctc    120

gctgccagcc caggaggcgc cttggcgcgg tgcccaggct gcgggcaagg ggtgcaggcg    180

ggttgtccag ggggctgcgt ggaggaggag gatggggggt cgccagccga gggctgcgcg    240

gaagctgagg gctgtctcag gagggagggg caggagtgcg gggtctacac ccctaactgc    300

gccccaggac tgcagtgcca tccgcccaag gacgacgagg cgcctttgcg ggcgctgctg    360

ctcggccgag gccgctgcct tccggcccgc gcgcctgctg ttgcagagga gaatcctaag    420

gagagtaaac cccaagcagg cactgcccgc ccacaggatg tgaaccgcag agaccaacag    480

aggaatccag gcacctctac cacgccctcc cagcccaatt ctgcgggtgt ccaagacact    540

gagatgggcc catgccgtag acatctggac tcagtgctgc agcaactcca gactgaggtc    600

taccgagggg ctcaaacact ctacgtgccc aattgtgacc atcgaggctt ctaccggaag    660

cggcagtgcc gctcctccca ggggcagcgc cgaggtccct gctggtgtgt ggatcggatg    720

ggcaagtccc tgccagggtc tccagatggc aatggaagct cctcctgccc cactgggagt    780

agcggctaaa gctgggggat agaggggctg cagggccact ggaaggaaca tggagctgtc    840

atcactcaac aaaaaaccga ggccctcaat ccaccttcag gccccgcccc atgggcccct    900

caccgctggt tggaaagagt gttggtgttg gctggggtgt caataaagct gtgcttgggg    960

tcgctgaaaa aaaaaaaaaa                                                980


<210>  198
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Thr Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys 
            20                  25                  30          


Gly Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu 
        35                  40                  45              


Asp Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu 
    50                  55                  60                  


Arg Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro 
65                  70                  75                  80  


Gly Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Leu Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Val 
            100                 105                 110         


Ala Glu Glu Asn Pro Lys Glu Ser Lys Pro Gln Ala Gly Thr Ala Arg 
        115                 120                 125             


Pro Gln Asp Val Asn Arg Arg Asp Gln Gln Arg Asn Pro Gly Thr Ser 
    130                 135                 140                 


Thr Thr Pro Ser Gln Pro Asn Ser Ala Gly Val Gln Asp Thr Glu Met 
145                 150                 155                 160 


Gly Pro Cys Arg Arg His Leu Asp Ser Val Leu Gln Gln Leu Gln Thr 
                165                 170                 175     


Glu Val Tyr Arg Gly Ala Gln Thr Leu Tyr Val Pro Asn Cys Asp His 
            180                 185                 190         


Arg Gly Phe Tyr Arg Lys Arg Gln Cys Arg Ser Ser Gln Gly Gln Arg 
        195                 200                 205             


Arg Gly Pro Cys Trp Cys Val Asp Arg Met Gly Lys Ser Leu Pro Gly 
    210                 215                 220                 


Ser Pro Asp Gly Asn Gly Ser Ser Ser Cys Pro Thr Gly Ser Ser Gly 
225                 230                 235                 240 


<210>  199
<211>  1299
<212>  DNA
<213>  Homo sapiens

<400>  199
atgaaattca agctgcttgc tgagtcctat tgccggctgc tgggagccag gagagccctg     60

aggagtagtc actcagtagc agctgacgcg tgggtccacc atgaactgga gtatctttga    120

gggactcctg agtggggtca acaagtactc cacagccttt gggcgcatct ggctgtctct    180

ggtcttcatc ttccgcgtgc tggtgtacct ggtgacggcc gagcgtgtgt ggagtgatga    240

ccacaaggac ttcgactgca atactcgcca gcccggctgc tccaacgtct gctttgatga    300

gttcttccct gtgtcccatg tgcgcctctg ggccctgcag cttatcctgg tgacatgccc    360

ctcactgctc gtggtcatgc acgtggccta ccgggaggtt caggagaaga ggcaccgaga    420

agcccatggg gagaacagtg ggcgcctcta cctgaacccc ggcaagaagc ggggtgggct    480

ctggtggaca tatgtctgca gcctagtgtt caaggcgagc gtggacatcg cctttctcta    540

tgtgttccac tcattctacc ccaaatatat cctccctcct gtggtcaagt gccacgcaga    600

tccatgtccc aatatagtgg actgcttcat ctccaagccc tcagagaaga acattttcac    660

cctcttcatg gtggccacag ctgccatctg catcctgctc aacctcgtgg agctcatcta    720

cctggtgagc aagagatgcc acgagtgcct ggcagcaagg aaagctcaag ccatgtgcac    780

aggtcatcac ccccacggta ccacctcttc ctgcaaacaa gacgacctcc tttcgggtga    840

cctcatcttt ctgggctcag acagtcatcc tcctctctta ccagaccgcc cccgagacca    900

tgtgaagaaa accatcttgt gaggggctgc ctggactggt ctggcaggtt gggcctggat    960

ggggaggctc tagcatctct cataggtgca acctgagagt gggggagcta agccatgagg   1020

taggggcagg caagagagag gattcagacg ctctgggagc cagttcctag tcctcaactc   1080

cagccacctg ccccagctcg acggcactgg gccagttccc cctctgctct gcagctcggt   1140

ttccttttct agaatggaaa tagtgagggc caatgcccag ggttggaggg aggagggcgt   1200

tcatagaaga acacacatgc gggcaccttc atcgtgtgtg gcccactgtc agaacttaat   1260

aaaagtcaac tcatttgctg gaaaaaaaaa aaaaaaaaa                          1299


<210>  200
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Asn Trp Ser Ile Phe Glu Gly Leu Leu Ser Gly Val Asn Lys Tyr 
1               5                   10                  15      


Ser Thr Ala Phe Gly Arg Ile Trp Leu Ser Leu Val Phe Ile Phe Arg 
            20                  25                  30          


Val Leu Val Tyr Leu Val Thr Ala Glu Arg Val Trp Ser Asp Asp His 
        35                  40                  45              


Lys Asp Phe Asp Cys Asn Thr Arg Gln Pro Gly Cys Ser Asn Val Cys 
    50                  55                  60                  


Phe Asp Glu Phe Phe Pro Val Ser His Val Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Leu Val Thr Cys Pro Ser Leu Leu Val Val Met His Val Ala 
                85                  90                  95      


Tyr Arg Glu Val Gln Glu Lys Arg His Arg Glu Ala His Gly Glu Asn 
            100                 105                 110         


Ser Gly Arg Leu Tyr Leu Asn Pro Gly Lys Lys Arg Gly Gly Leu Trp 
        115                 120                 125             


Trp Thr Tyr Val Cys Ser Leu Val Phe Lys Ala Ser Val Asp Ile Ala 
    130                 135                 140                 


Phe Leu Tyr Val Phe His Ser Phe Tyr Pro Lys Tyr Ile Leu Pro Pro 
145                 150                 155                 160 


Val Val Lys Cys His Ala Asp Pro Cys Pro Asn Ile Val Asp Cys Phe 
                165                 170                 175     


Ile Ser Lys Pro Ser Glu Lys Asn Ile Phe Thr Leu Phe Met Val Ala 
            180                 185                 190         


Thr Ala Ala Ile Cys Ile Leu Leu Asn Leu Val Glu Leu Ile Tyr Leu 
        195                 200                 205             


Val Ser Lys Arg Cys His Glu Cys Leu Ala Ala Arg Lys Ala Gln Ala 
    210                 215                 220                 


Met Cys Thr Gly His His Pro His Gly Thr Thr Ser Ser Cys Lys Gln 
225                 230                 235                 240 


Asp Asp Leu Leu Ser Gly Asp Leu Ile Phe Leu Gly Ser Asp Ser His 
                245                 250                 255     


Pro Pro Leu Leu Pro Asp Arg Pro Arg Asp His Val Lys Lys Thr Ile 
            260                 265                 270         


Leu 
    


<210>  201
<211>  1925
<212>  DNA
<213>  Homo sapiens

<400>  201
actccaggtc ccctatcctg tcctctgcaa cccaaacgtc caggaggatc atgacctgcg     60

gatcaggatt tggtgggcgc gccttcagct gcatctcggc ctgcgggccg cgccccggcc    120

gctgctgcat caccgccgcc ccctaccgtg gcatctcctg ctaccgcggc ctcaccgggg    180

gcttcggcag ccacagcgtg tgcggaggct ttcgggccgg ctcctgcgga cgcagcttcg    240

gctaccgctc cgggggcgtg tgcgggccca gtcccccatg catcaccacc gtgtcggtca    300

acgagagcct cctcacgccc ctcaacctgg agatcgaccc caacgcgcag tgcgtgaagc    360

aggaggagaa ggagcagatc aagtccctca acagcaggtt cgcggccttc atcgacaagg    420

tgcgcttcct ggagcagcag aacaaactgc tggagacaaa gctgcagttc taccagaacc    480

gcgagtgttg ccagagcaac ctggagcccc tgtttgaggg ctacatcgag actctgcggc    540

gggaggccga gtgcgtggag gccgacagcg ggaggctggc ctcagagctt aaccacgtgc    600

aggaggtgct ggagggctac aagaagaagt atgaggagga ggtttctctg agagcaacag    660

ctgagaacga gtttgtggct ctgaagaagg atgtggactg cgcctacctc cgcaagtcag    720

acctggaggc caacgtggag gccctgatcc aggagatcga cttcctgagg cggctgtatg    780

aggaggagat ccgcattctc cagtcgcaca tctcagacac ctccgtggtt gtcaagctgg    840

acaacagccg ggacctgaac atggactgca tcattgccga gattaaggca cagtatgacg    900

acattgtcac ccgcagccgg gccgaggccg agtcctggta ccgcagcaag tgtgaggaga    960

tgaaggccac ggtgatcagg cacggggaga ccctgcgccg caccaaggag gagatcaatg   1020

agctgaaccg catgatccaa aggctgacgg ccgaggtgga gaatgccaag tgccagaact   1080

ccaagctgga ggccgcggtg gctcagtctg agcagcaggg tgaggcagcc ctcagtgatg   1140

cccgctgcaa gctggccgag ctggagggcg ccctgcagaa ggccaagcag gacatggcct   1200

gcctgatcag ggagtaccag gaggtgatga actccaagct gggcctggac atcgagatcg   1260

ccacctacag gcgcctgctg gagggcgagg agcagaggct atgtgaaggc attggggctg   1320

tgaatgtctg tgtcagcagc tcccggggcg gggtcgtgtg cggggacctc tgcgtgtcag   1380

gctcccggcc agtgactggc agtgtctgca gcgctccgtg caacgggaac gtggcggtga   1440

gcaccggcct gtgtgcgccc tgcggccaat tgaacaccac ctgcggaggg ggttcctgcg   1500

gcgtgggctc ctgtggtatc agctccctgg gtgtggggtc ttgcggcagc agctgccgga   1560

aatgttaggc accccaactc aagtcccagg ccccaggcat ctttgcctgc cctgccttgc   1620

ttggcccagt cagtcaggcg cctggagaag tgctcagcta cttctcctgc actttgaaag   1680

acccctccca ctcctggcct cacatttctc tgtgtgatcc cccacttctg ggctctgcca   1740

ccccacagtg ggaaaggcca ccctagaaag aagtccgctg gcacccatag gaaggggcct   1800

caggagcagg aagggccagg accagaacct tgcccacggc aactgccttc ctgcctctcc   1860

ccttcctcct ctgctcttga tctgtgtttc aataaattaa tgtagccaaa aaaaaaaaaa   1920

aaaaa                                                               1925


<210>  202
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Thr Cys Gly Ser Gly Phe Gly Gly Arg Ala Phe Ser Cys Ile Ser 
1               5                   10                  15      


Ala Cys Gly Pro Arg Pro Gly Arg Cys Cys Ile Thr Ala Ala Pro Tyr 
            20                  25                  30          


Arg Gly Ile Ser Cys Tyr Arg Gly Leu Thr Gly Gly Phe Gly Ser His 
        35                  40                  45              


Ser Val Cys Gly Gly Phe Arg Ala Gly Ser Cys Gly Arg Ser Phe Gly 
    50                  55                  60                  


Tyr Arg Ser Gly Gly Val Cys Gly Pro Ser Pro Pro Cys Ile Thr Thr 
65                  70                  75                  80  


Val Ser Val Asn Glu Ser Leu Leu Thr Pro Leu Asn Leu Glu Ile Asp 
                85                  90                  95      


Pro Asn Ala Gln Cys Val Lys Gln Glu Glu Lys Glu Gln Ile Lys Ser 
            100                 105                 110         


Leu Asn Ser Arg Phe Ala Ala Phe Ile Asp Lys Val Arg Phe Leu Glu 
        115                 120                 125             


Gln Gln Asn Lys Leu Leu Glu Thr Lys Leu Gln Phe Tyr Gln Asn Arg 
    130                 135                 140                 


Glu Cys Cys Gln Ser Asn Leu Glu Pro Leu Phe Glu Gly Tyr Ile Glu 
145                 150                 155                 160 


Thr Leu Arg Arg Glu Ala Glu Cys Val Glu Ala Asp Ser Gly Arg Leu 
                165                 170                 175     


Ala Ser Glu Leu Asn His Val Gln Glu Val Leu Glu Gly Tyr Lys Lys 
            180                 185                 190         


Lys Tyr Glu Glu Glu Val Ser Leu Arg Ala Thr Ala Glu Asn Glu Phe 
        195                 200                 205             


Val Ala Leu Lys Lys Asp Val Asp Cys Ala Tyr Leu Arg Lys Ser Asp 
    210                 215                 220                 


Leu Glu Ala Asn Val Glu Ala Leu Ile Gln Glu Ile Asp Phe Leu Arg 
225                 230                 235                 240 


Arg Leu Tyr Glu Glu Glu Ile Arg Ile Leu Gln Ser His Ile Ser Asp 
                245                 250                 255     


Thr Ser Val Val Val Lys Leu Asp Asn Ser Arg Asp Leu Asn Met Asp 
            260                 265                 270         


Cys Ile Ile Ala Glu Ile Lys Ala Gln Tyr Asp Asp Ile Val Thr Arg 
        275                 280                 285             


Ser Arg Ala Glu Ala Glu Ser Trp Tyr Arg Ser Lys Cys Glu Glu Met 
    290                 295                 300                 


Lys Ala Thr Val Ile Arg His Gly Glu Thr Leu Arg Arg Thr Lys Glu 
305                 310                 315                 320 


Glu Ile Asn Glu Leu Asn Arg Met Ile Gln Arg Leu Thr Ala Glu Val 
                325                 330                 335     


Glu Asn Ala Lys Cys Gln Asn Ser Lys Leu Glu Ala Ala Val Ala Gln 
            340                 345                 350         


Ser Glu Gln Gln Gly Glu Ala Ala Leu Ser Asp Ala Arg Cys Lys Leu 
        355                 360                 365             


Ala Glu Leu Glu Gly Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Cys 
    370                 375                 380                 


Leu Ile Arg Glu Tyr Gln Glu Val Met Asn Ser Lys Leu Gly Leu Asp 
385                 390                 395                 400 


Ile Glu Ile Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu Glu Gln Arg 
                405                 410                 415     


Leu Cys Glu Gly Ile Gly Ala Val Asn Val Cys Val Ser Ser Ser Arg 
            420                 425                 430         


Gly Gly Val Val Cys Gly Asp Leu Cys Val Ser Gly Ser Arg Pro Val 
        435                 440                 445             


Thr Gly Ser Val Cys Ser Ala Pro Cys Asn Gly Asn Val Ala Val Ser 
    450                 455                 460                 


Thr Gly Leu Cys Ala Pro Cys Gly Gln Leu Asn Thr Thr Cys Gly Gly 
465                 470                 475                 480 


Gly Ser Cys Gly Val Gly Ser Cys Gly Ile Ser Ser Leu Gly Val Gly 
                485                 490                 495     


Ser Cys Gly Ser Ser Cys Arg Lys Cys 
            500                 505 


<210>  203
<211>  4996
<212>  DNA
<213>  Homo sapiens

<400>  203
agtgctcgcc cgcccgaccc cggcggctcg cgcccgggag cgccgcaggg tcgctagagt     60

cggccgcgtc ctttgtgtgg cgctcaggct gcgccgcggg gcggcgggac ggaatgtggg    120

cgctgcgggg gcttttctct cctacccgaa ctgtgggaac aatggactga aaggggaaga    180

tggattgagg ggccgagcgg ggaagcgagc tgcaccgggg aatcatgact tctgcagccg    240

agataaagaa gccaccagtg gcccccaagc ccaagtttgt tgtggcaaat aataagccag    300

ccccacctcc tattgcacct aaacccgaca ttgtgatttc tagtgttcca cagtcgacaa    360

agaaaatgaa accagcaata gccccaaaac caaaagtcct gaagacctca cctgttcgag    420

agattgggca gtcgccatca aggaaaatca tgttgaacct ggaagggcat aaacaggaat    480

tagctgaaag cactgacaac tttaattgta aatatgaagg caatcagagc aatgattata    540

tttcaccaat gtgttcctgc agttctgagt gtatccataa gctgggccat agagagaatt    600

tgtgtgtaaa gcagcttgtt ttagagcccc tggaaatgaa tgaaaattta gaaaacagta    660

aaattgatga gactttgact ataaaaacta ggagtaaatg tgatttgtat ggtgaaaaag    720

ccaagaacca gggtggggtt gttttaaagg caagcgtttt agaagaggag ctcaaagatg    780

ccttaataca ccaaatgcca ccttttattt ctgcacagaa gcacaggccc acagacagcc    840

cagaaatgaa tggtggctgt aattcaaatg gacaattcag aattgaattt gcggatttgt    900

caccttcccc atccagcttt gaaaaagttc ctgatcatca cagttgccac ttacagcttc    960

ctagtgatga atgtgaacat tttgaaactt gccaggatga cagtgaaaaa agcaataatt   1020

gctttcagtc atctgaacta gaggctctgg aaaatgggaa aaggagtact ttaatatctt   1080

cagatggagt tagtaagaaa tcagaagtca aagaccttgg tcccttagaa attcatttag   1140

taccatatac cccaaaattt ccaactccca agcccagaaa gacacgaact gctcgtctgt   1200

tacgccaaaa gtgtgtagat actcctagtg aaagcactga agaaccgggg aattcagaca   1260

gtagctcttc ctgtcttact gaaaatagtt tgaaaatcaa taaaatcagt gttctgcatc   1320

agaatgtttt gtgtaagcag gaacaggtgg ataaaatgaa gctaggaaat aaaagtgaat   1380

tgaatatgga atccaacagt gatgcacagg acttagtcaa ttcacagaaa gccatgtgta   1440

atgaaacaac ttcctttgaa aaaatggcac cttcttttga taaagactct aatttgagtt   1500

ctgacagcac aactgtagat ggttctagta tgtcgcttgc tgtggacgaa gggaccggtt   1560

ttataagatg tactgtatct atgagcctgc ctaagcagct caaattaact tgcaatgaac   1620

atttgcaatc tgggagaaac ctgggagttt ctgcccctca aatgcaaaag gaatctgtta   1680

taaaagagga aaattctcta cgaattgtcc ccaaaaaacc tcaaagacat agcttgcctg   1740

ctacaggagt gcttaaaaag gctgcctccg aggagctttt ggaaaaaagt tcttatcctt   1800

caagtgaaga aaaaagttca gagaagagtc tagaaagaaa tcaccttcag catttgtgtg   1860

cccaaaaccg tggtgtgtca tcctcctttg atatgcctaa acgggcttca gaaaagccag   1920

tgtggaagtt acctcatcct attttaccct tttcagggaa cccagaattc ttaaagtctg   1980

tcaccgtatc gtcaaacagt gagccttcaa cagccctaac caagcccaga gcaaaatcgt   2040

tatctgctat ggatgtggaa aagtgcacta agccttgcaa agactctaca aagaaaaact   2100

cttttaaaaa gttgctcagc atgaaactgt ccatctgttt catgaagagt gactttcaaa   2160

aattttggtc caagagtagc caactcggag acaccaccac aggccacctc tccagtgggg   2220

agcagaaggg gattgaaagt gattggcaag gcttgttggt aggagaggag aagagaagta   2280

aacccatcaa ggcatattcc acagaaaact atagcctgga atctcaaaag aagaggaaga   2340

agtctcgggg ccagaccagt gcagctaatg gtctgagagc tgagtctttg gatgaccaaa   2400

tgctctcccg ggagtcatca tctcaggcac cttacaagtc tgttacaagc ctctgtgcac   2460

cggagtatga aaatatacgc cattatgagg aaataccaga gtacgagaac ttgccattta   2520

ttatggctat acggaaaact caagagttgg aatggcagaa ttccagcagc atggaggacg   2580

ctgatgcaaa tgtgtatgag gtagaagagc catatgaagc tccagatggc cagctgcagc   2640

ttggacccag acatcagcat tccagttcag gagcatccca ggaggaacag aatgatcttg   2700

gtcttggtga ccttccctct gatgaggagg aaatcatcaa cagttctgat gaagatgatg   2760

tcagctctga gtcaagtaaa ggagagcctg acccactgga agataaacag gatgaagata   2820

atggaatgaa aagtaaagtt catcatattg ccaaggagat catgagctca gagaaagtgt   2880

ttgtggatgt gttaaaactt ttgcatattg atttccggga tgcagtagct catgcttcca   2940

ggcaacttgg gaaaccagtg attgaggacc ggattctaaa tcagatccta tactacttgc   3000

ctcagctgta tgagctcaac cgggatctct tgaaggaact ggaggaaaga atgttgcact   3060

ggactgaaca tcagagaatt gctgatatct ttgtaaagaa gggaccatat ctaaaaatgt   3120

attccacata catcaaagaa tttgataaga atatagcctt gctggatgaa cagtgcaaga   3180

aaaatccagg ttttgctgct gttgttagag aatttgagat gagccctcgc tgtgctaatc   3240

tggccctcaa gcactacctg ctcaagccgg ttcagaggat cccccagtac aggctgttgc   3300

tgacagatta tttgaagaat ctcatagaag atgctggaga ttacagagac actcaagatg   3360

cccttgctgt tgttatagag gtagccaacc acgccaatga caccatgaag caaggagaca   3420

actttcagaa acttatgcaa attcagtaca gcttaaatgg acaccatgaa attgtgcagc   3480

ctggtcgggt ttttctcaaa gaaggaattc tgatgaagct gtctcggaaa gtgatgcaac   3540

ctcgaatgtt tttcctgttt aatgatgccc tgctgtatac aacaccagtg cagtctggga   3600

tgtataaact gaacaacatg ctctcactgg ctggaatgaa ggtcagaaaa cctacccaag   3660

aagcctatca gaatgaatta aagattgaaa gtgtagaacg ttccttcatt ctctcagcca   3720

gttctgccac agaaagggat gaatggctag aagcgatttc cagggcaata gaagagtatg   3780

ccaagaaaag aatcaccttc tgtcctagta ggagtcttga tgaggcagac tcagaaaata   3840

aagaagaagt tagtcctctt ggatcgaagg ctcccatctg gattcctgat accagagcca   3900

caatgtgtat gatctgcaca agcgaattca ctctcacctg gagacgacac cactgccggg   3960

cctgtggaaa gattgtatgc caagcttgtt cgtctaataa gtatggctta gattacctga   4020

aaaatcaacc agcaagagta tgtgaacatt gtttccaaga actgcagaaa ttagatcacc   4080

agcactcccc taggattgga tctcctggaa atcacaaatc tccttcaagt gccttatcat   4140

cagtcttaca tagcattcca tcagggagga aacagaaaaa aatcccagct gctctcaaag   4200

aagtatcagc aaacacagag gattcttcta tgagtggcta cttgtacaga tcaaagggca   4260

ataaaaaacc ctggaaacac ttttggtttg tcataaaaaa taaagtacta tatacatatg   4320

ctgcaagtga ggacgtggcc gctttggaga gtcagccttt attaggattc actgttattc   4380

aagttaaaga tgagaattcc gagtctaaag tatttcagtt actgcacaaa aacatgttat   4440

tttatgtatt caaagcagag gatgctcatt cggctcagaa gtggatagaa gcatttcagg   4500

aaggcacaat attgtagcag tattggtttc atctcttctg tgattccaaa gaggtggaat   4560

ttcatcagaa tggagtaaat gcaattcaaa aattgtataa aaatgaacac tgccaagata   4620

aagccaacca gacccttcat caaagaaatt gttttgttag gtataagcaa tttttaaaag   4680

gtgtttgttt tttcatttat gttatttatt aaaattttga tgtttactta atggtcagaa   4740

ttatttctga gacacactga attctaaagt accatttctt tagagaccag aaaaactatc   4800

ttaatactgt atactgtatt aactattcgt gacatagttc acactgtttt cttaccttac   4860

attgtaacaa tcttactggt ggaaagtctt tgtaaggaaa aaacacatag caaggagcaa   4920

atttccacaa agtgcttggt ttaggaattg tgattattat aaaactgctg atgaaaaaaa   4980

tgcatgtctt tgaatc                                                   4996


<210>  204
<211>  1430
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Thr Ser Ala Ala Glu Ile Lys Lys Pro Pro Val Ala Pro Lys Pro 
1               5                   10                  15      


Lys Phe Val Val Ala Asn Asn Lys Pro Ala Pro Pro Pro Ile Ala Pro 
            20                  25                  30          


Lys Pro Asp Ile Val Ile Ser Ser Val Pro Gln Ser Thr Lys Lys Met 
        35                  40                  45              


Lys Pro Ala Ile Ala Pro Lys Pro Lys Val Leu Lys Thr Ser Pro Val 
    50                  55                  60                  


Arg Glu Ile Gly Gln Ser Pro Ser Arg Lys Ile Met Leu Asn Leu Glu 
65                  70                  75                  80  


Gly His Lys Gln Glu Leu Ala Glu Ser Thr Asp Asn Phe Asn Cys Lys 
                85                  90                  95      


Tyr Glu Gly Asn Gln Ser Asn Asp Tyr Ile Ser Pro Met Cys Ser Cys 
            100                 105                 110         


Ser Ser Glu Cys Ile His Lys Leu Gly His Arg Glu Asn Leu Cys Val 
        115                 120                 125             


Lys Gln Leu Val Leu Glu Pro Leu Glu Met Asn Glu Asn Leu Glu Asn 
    130                 135                 140                 


Ser Lys Ile Asp Glu Thr Leu Thr Ile Lys Thr Arg Ser Lys Cys Asp 
145                 150                 155                 160 


Leu Tyr Gly Glu Lys Ala Lys Asn Gln Gly Gly Val Val Leu Lys Ala 
                165                 170                 175     


Ser Val Leu Glu Glu Glu Leu Lys Asp Ala Leu Ile His Gln Met Pro 
            180                 185                 190         


Pro Phe Ile Ser Ala Gln Lys His Arg Pro Thr Asp Ser Pro Glu Met 
        195                 200                 205             


Asn Gly Gly Cys Asn Ser Asn Gly Gln Phe Arg Ile Glu Phe Ala Asp 
    210                 215                 220                 


Leu Ser Pro Ser Pro Ser Ser Phe Glu Lys Val Pro Asp His His Ser 
225                 230                 235                 240 


Cys His Leu Gln Leu Pro Ser Asp Glu Cys Glu His Phe Glu Thr Cys 
                245                 250                 255     


Gln Asp Asp Ser Glu Lys Ser Asn Asn Cys Phe Gln Ser Ser Glu Leu 
            260                 265                 270         


Glu Ala Leu Glu Asn Gly Lys Arg Ser Thr Leu Ile Ser Ser Asp Gly 
        275                 280                 285             


Val Ser Lys Lys Ser Glu Val Lys Asp Leu Gly Pro Leu Glu Ile His 
    290                 295                 300                 


Leu Val Pro Tyr Thr Pro Lys Phe Pro Thr Pro Lys Pro Arg Lys Thr 
305                 310                 315                 320 


Arg Thr Ala Arg Leu Leu Arg Gln Lys Cys Val Asp Thr Pro Ser Glu 
                325                 330                 335     


Ser Thr Glu Glu Pro Gly Asn Ser Asp Ser Ser Ser Ser Cys Leu Thr 
            340                 345                 350         


Glu Asn Ser Leu Lys Ile Asn Lys Ile Ser Val Leu His Gln Asn Val 
        355                 360                 365             


Leu Cys Lys Gln Glu Gln Val Asp Lys Met Lys Leu Gly Asn Lys Ser 
    370                 375                 380                 


Glu Leu Asn Met Glu Ser Asn Ser Asp Ala Gln Asp Leu Val Asn Ser 
385                 390                 395                 400 


Gln Lys Ala Met Cys Asn Glu Thr Thr Ser Phe Glu Lys Met Ala Pro 
                405                 410                 415     


Ser Phe Asp Lys Asp Ser Asn Leu Ser Ser Asp Ser Thr Thr Val Asp 
            420                 425                 430         


Gly Ser Ser Met Ser Leu Ala Val Asp Glu Gly Thr Gly Phe Ile Arg 
        435                 440                 445             


Cys Thr Val Ser Met Ser Leu Pro Lys Gln Leu Lys Leu Thr Cys Asn 
    450                 455                 460                 


Glu His Leu Gln Ser Gly Arg Asn Leu Gly Val Ser Ala Pro Gln Met 
465                 470                 475                 480 


Gln Lys Glu Ser Val Ile Lys Glu Glu Asn Ser Leu Arg Ile Val Pro 
                485                 490                 495     


Lys Lys Pro Gln Arg His Ser Leu Pro Ala Thr Gly Val Leu Lys Lys 
            500                 505                 510         


Ala Ala Ser Glu Glu Leu Leu Glu Lys Ser Ser Tyr Pro Ser Ser Glu 
        515                 520                 525             


Glu Lys Ser Ser Glu Lys Ser Leu Glu Arg Asn His Leu Gln His Leu 
    530                 535                 540                 


Cys Ala Gln Asn Arg Gly Val Ser Ser Ser Phe Asp Met Pro Lys Arg 
545                 550                 555                 560 


Ala Ser Glu Lys Pro Val Trp Lys Leu Pro His Pro Ile Leu Pro Phe 
                565                 570                 575     


Ser Gly Asn Pro Glu Phe Leu Lys Ser Val Thr Val Ser Ser Asn Ser 
            580                 585                 590         


Glu Pro Ser Thr Ala Leu Thr Lys Pro Arg Ala Lys Ser Leu Ser Ala 
        595                 600                 605             


Met Asp Val Glu Lys Cys Thr Lys Pro Cys Lys Asp Ser Thr Lys Lys 
    610                 615                 620                 


Asn Ser Phe Lys Lys Leu Leu Ser Met Lys Leu Ser Ile Cys Phe Met 
625                 630                 635                 640 


Lys Ser Asp Phe Gln Lys Phe Trp Ser Lys Ser Ser Gln Leu Gly Asp 
                645                 650                 655     


Thr Thr Thr Gly His Leu Ser Ser Gly Glu Gln Lys Gly Ile Glu Ser 
            660                 665                 670         


Asp Trp Gln Gly Leu Leu Val Gly Glu Glu Lys Arg Ser Lys Pro Ile 
        675                 680                 685             


Lys Ala Tyr Ser Thr Glu Asn Tyr Ser Leu Glu Ser Gln Lys Lys Arg 
    690                 695                 700                 


Lys Lys Ser Arg Gly Gln Thr Ser Ala Ala Asn Gly Leu Arg Ala Glu 
705                 710                 715                 720 


Ser Leu Asp Asp Gln Met Leu Ser Arg Glu Ser Ser Ser Gln Ala Pro 
                725                 730                 735     


Tyr Lys Ser Val Thr Ser Leu Cys Ala Pro Glu Tyr Glu Asn Ile Arg 
            740                 745                 750         


His Tyr Glu Glu Ile Pro Glu Tyr Glu Asn Leu Pro Phe Ile Met Ala 
        755                 760                 765             


Ile Arg Lys Thr Gln Glu Leu Glu Trp Gln Asn Ser Ser Ser Met Glu 
    770                 775                 780                 


Asp Ala Asp Ala Asn Val Tyr Glu Val Glu Glu Pro Tyr Glu Ala Pro 
785                 790                 795                 800 


Asp Gly Gln Leu Gln Leu Gly Pro Arg His Gln His Ser Ser Ser Gly 
                805                 810                 815     


Ala Ser Gln Glu Glu Gln Asn Asp Leu Gly Leu Gly Asp Leu Pro Ser 
            820                 825                 830         


Asp Glu Glu Glu Ile Ile Asn Ser Ser Asp Glu Asp Asp Val Ser Ser 
        835                 840                 845             


Glu Ser Ser Lys Gly Glu Pro Asp Pro Leu Glu Asp Lys Gln Asp Glu 
    850                 855                 860                 


Asp Asn Gly Met Lys Ser Lys Val His His Ile Ala Lys Glu Ile Met 
865                 870                 875                 880 


Ser Ser Glu Lys Val Phe Val Asp Val Leu Lys Leu Leu His Ile Asp 
                885                 890                 895     


Phe Arg Asp Ala Val Ala His Ala Ser Arg Gln Leu Gly Lys Pro Val 
            900                 905                 910         


Ile Glu Asp Arg Ile Leu Asn Gln Ile Leu Tyr Tyr Leu Pro Gln Leu 
        915                 920                 925             


Tyr Glu Leu Asn Arg Asp Leu Leu Lys Glu Leu Glu Glu Arg Met Leu 
    930                 935                 940                 


His Trp Thr Glu His Gln Arg Ile Ala Asp Ile Phe Val Lys Lys Gly 
945                 950                 955                 960 


Pro Tyr Leu Lys Met Tyr Ser Thr Tyr Ile Lys Glu Phe Asp Lys Asn 
                965                 970                 975     


Ile Ala Leu Leu Asp Glu Gln Cys Lys Lys Asn Pro Gly Phe Ala Ala 
            980                 985                 990         


Val Val Arg Glu Phe Glu Met Ser  Pro Arg Cys Ala Asn  Leu Ala Leu 
        995                 1000                 1005             


Lys His  Tyr Leu Leu Lys Pro  Val Gln Arg Ile Pro  Gln Tyr Arg 
    1010                 1015                 1020             


Leu Leu  Leu Thr Asp Tyr Leu  Lys Asn Leu Ile Glu  Asp Ala Gly 
    1025                 1030                 1035             


Asp Tyr  Arg Asp Thr Gln Asp  Ala Leu Ala Val Val  Ile Glu Val 
    1040                 1045                 1050             


Ala Asn  His Ala Asn Asp Thr  Met Lys Gln Gly Asp  Asn Phe Gln 
    1055                 1060                 1065             


Lys Leu  Met Gln Ile Gln Tyr  Ser Leu Asn Gly His  His Glu Ile 
    1070                 1075                 1080             


Val Gln  Pro Gly Arg Val Phe  Leu Lys Glu Gly Ile  Leu Met Lys 
    1085                 1090                 1095             


Leu Ser  Arg Lys Val Met Gln  Pro Arg Met Phe Phe  Leu Phe Asn 
    1100                 1105                 1110             


Asp Ala  Leu Leu Tyr Thr Thr  Pro Val Gln Ser Gly  Met Tyr Lys 
    1115                 1120                 1125             


Leu Asn  Asn Met Leu Ser Leu  Ala Gly Met Lys Val  Arg Lys Pro 
    1130                 1135                 1140             


Thr Gln  Glu Ala Tyr Gln Asn  Glu Leu Lys Ile Glu  Ser Val Glu 
    1145                 1150                 1155             


Arg Ser  Phe Ile Leu Ser Ala  Ser Ser Ala Thr Glu  Arg Asp Glu 
    1160                 1165                 1170             


Trp Leu  Glu Ala Ile Ser Arg  Ala Ile Glu Glu Tyr  Ala Lys Lys 
    1175                 1180                 1185             


Arg Ile  Thr Phe Cys Pro Ser  Arg Ser Leu Asp Glu  Ala Asp Ser 
    1190                 1195                 1200             


Glu Asn  Lys Glu Glu Val Ser  Pro Leu Gly Ser Lys  Ala Pro Ile 
    1205                 1210                 1215             


Trp Ile  Pro Asp Thr Arg Ala  Thr Met Cys Met Ile  Cys Thr Ser 
    1220                 1225                 1230             


Glu Phe  Thr Leu Thr Trp Arg  Arg His His Cys Arg  Ala Cys Gly 
    1235                 1240                 1245             


Lys Ile  Val Cys Gln Ala Cys  Ser Ser Asn Lys Tyr  Gly Leu Asp 
    1250                 1255                 1260             


Tyr Leu  Lys Asn Gln Pro Ala  Arg Val Cys Glu His  Cys Phe Gln 
    1265                 1270                 1275             


Glu Leu  Gln Lys Leu Asp His  Gln His Ser Pro Arg  Ile Gly Ser 
    1280                 1285                 1290             


Pro Gly  Asn His Lys Ser Pro  Ser Ser Ala Leu Ser  Ser Val Leu 
    1295                 1300                 1305             


His Ser  Ile Pro Ser Gly Arg  Lys Gln Lys Lys Ile  Pro Ala Ala 
    1310                 1315                 1320             


Leu Lys  Glu Val Ser Ala Asn  Thr Glu Asp Ser Ser  Met Ser Gly 
    1325                 1330                 1335             


Tyr Leu  Tyr Arg Ser Lys Gly  Asn Lys Lys Pro Trp  Lys His Phe 
    1340                 1345                 1350             


Trp Phe  Val Ile Lys Asn Lys  Val Leu Tyr Thr Tyr  Ala Ala Ser 
    1355                 1360                 1365             


Glu Asp  Val Ala Ala Leu Glu  Ser Gln Pro Leu Leu  Gly Phe Thr 
    1370                 1375                 1380             


Val Ile  Gln Val Lys Asp Glu  Asn Ser Glu Ser Lys  Val Phe Gln 
    1385                 1390                 1395             


Leu Leu  His Lys Asn Met Leu  Phe Tyr Val Phe Lys  Ala Glu Asp 
    1400                 1405                 1410             


Ala His  Ser Ala Gln Lys Trp  Ile Glu Ala Phe Gln  Glu Gly Thr 
    1415                 1420                 1425             


Ile Leu  
    1430 


<210>  205
<211>  1930
<212>  DNA
<213>  Homo sapiens

<400>  205
gaccaagtgg ctcctgcgat ggcggcggaa gaggaggctg cggcgggagg taaagtgttg     60

agagaggaga accagtgcat tgctcctgtg gtttccagcc gcgtgagtcc agggacaaga    120

ccaacagcta tggggtcttt cagctcacac atgacagagt ttccacgaaa acgcaaagga    180

agtgattcag acccatccca gtcaggaatc atgacagaaa aagtggtgga aaagctttct    240

cagaatcccc ttacctatct tctttcaaca aggatagaaa tatcagcctc cagtggcagc    300

agagtggaag atggtgaaca ccaagttaaa atgaaggcct tcagagaagc tcatagccaa    360

actgaaaagc ggaggagaga taaaatgaat aacctgattg aagaactgtc tgcaatgatc    420

cctcagtgca accccatggc gcgtaaactg gacaaactta cagttttaag aatggctgtt    480

caacacttga gatctttaaa aggcttgaca aattcttatg tgggaagtaa ttatagacca    540

tcatttcttc aggataatga gctcagacat ttaatcctta agactgcaga aggcttctta    600

tttgtggttg gatgtgaaag aggaaaaatt ctcttcgttt ctaagtcagt ctccaaaata    660

cttaattatg atcaggctag tttgactgga caaagcttat ttgacttctt acatccaaaa    720

gatgttgcca aagtaaagga acaactttct tcttttgata tttcaccaag agaaaagcta    780

atagatgcca aaactggttt gcaagttcac agtaatctcc acgctggaag gacacgtgtg    840

tattctggct caagacgatc ttttttctgt cggataaaga gttgtaaaat ctctgtcaaa    900

gaagagcatg gatgcttacc caactcaaag aagaaagagc acagaaaatt ctatactatc    960

cattgcactg gttacttgag aagctggcct ccaaatattg ttggaatgga agaagaaagg   1020

aacagtaaga aagacaacag taattttacc tgccttgtgg ccattggaag attacagcca   1080

tatattgttc cacagaacag tggagagatt aatgtgaaac caactgaatt tataacccgg   1140

tttgcagtga atggaaaatt tgtctatgta gatcaaaggg caacagcgat tttaggatat   1200

ctgcctcagg aacttttggg aacttcttgt tatgaatatt ttcatcaaga tgaccacaat   1260

aatttgactg acaagcacaa agcagttcta cagagtaagg agaaaatact tacagattcc   1320

tacaaattca gagcaaaaga tggctctttt gtaactttaa aaagccaatg gtttagtttc   1380

acaaatcctt ggacaaaaga actggaatat attgtatctg tcaacacttt agttttggga   1440

catagtgagc ctggagaagc atcattttta ccttgtagct ctcaatcatc agaagaatcc   1500

tctagacagt cctgtatgag tgtacctgga atgtctactg gaacagtact tggtgctggt   1560

agtattggaa cagatattgc aaatgaaatt ctggatttac agaggttaca gtcttcttca   1620

taccttgatg attcgagtcc aacaggttta atgaaagata ctcatactgt aaactgcagg   1680

agtatgtcaa ataaggagtt gtttccacca agtccttctg aaatggggga gctagaggct   1740

accaggcaaa accagagtac tgttgctgtc cacagccatg agccactcct cagtgatggt   1800

gcacagttgg atttcgatgc cctatgtgac aatgatgaca cagccatggc tgcatttatg   1860

aattacttag aagcagaggg gggcctggga gaccctgggg acttcagtga catccagtgg   1920

accctctagc                                                          1930


<210>  206
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu 
1               5                   10                  15      


Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly 
            20                  25                  30          


Thr Arg Pro Thr Ala Met Gly Ser Phe Ser Ser His Met Thr Glu Phe 
        35                  40                  45              


Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Ser Gly Ile 
    50                  55                  60                  


Met Thr Glu Lys Val Val Glu Lys Leu Ser Gln Asn Pro Leu Thr Tyr 
65                  70                  75                  80  


Leu Leu Ser Thr Arg Ile Glu Ile Ser Ala Ser Ser Gly Ser Arg Val 
                85                  90                  95      


Glu Asp Gly Glu His Gln Val Lys Met Lys Ala Phe Arg Glu Ala His 
            100                 105                 110         


Ser Gln Thr Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu 
        115                 120                 125             


Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu 
    130                 135                 140                 


Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His Leu Arg Ser Leu 
145                 150                 155                 160 


Lys Gly Leu Thr Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe 
                165                 170                 175     


Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Thr Ala Glu Gly 
            180                 185                 190         


Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser 
        195                 200                 205             


Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu Thr Gly 
    210                 215                 220                 


Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys Val Lys 
225                 230                 235                 240 


Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp 
                245                 250                 255     


Ala Lys Thr Gly Leu Gln Val His Ser Asn Leu His Ala Gly Arg Thr 
            260                 265                 270         


Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser 
        275                 280                 285             


Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys 
    290                 295                 300                 


Lys Lys Glu His Arg Lys Phe Tyr Thr Ile His Cys Thr Gly Tyr Leu 
305                 310                 315                 320 


Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser 
                325                 330                 335     


Lys Lys Asp Asn Ser Asn Phe Thr Cys Leu Val Ala Ile Gly Arg Leu 
            340                 345                 350         


Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro 
        355                 360                 365             


Thr Glu Phe Ile Thr Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val 
    370                 375                 380                 


Asp Gln Arg Ala Thr Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu 
385                 390                 395                 400 


Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu 
                405                 410                 415     


Thr Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Thr 
            420                 425                 430         


Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Thr Leu Lys 
        435                 440                 445             


Ser Gln Trp Phe Ser Phe Thr Asn Pro Trp Thr Lys Glu Leu Glu Tyr 
    450                 455                 460                 


Ile Val Ser Val Asn Thr Leu Val Leu Gly His Ser Glu Pro Gly Glu 
465                 470                 475                 480 


Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg 
                485                 490                 495     


Gln Ser Cys Met Ser Val Pro Gly Met Ser Thr Gly Thr Val Leu Gly 
            500                 505                 510         


Ala Gly Ser Ile Gly Thr Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln 
        515                 520                 525             


Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Thr Gly Leu 
    530                 535                 540                 


Met Lys Asp Thr His Thr Val Asn Cys Arg Ser Met Ser Asn Lys Glu 
545                 550                 555                 560 


Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala Thr Arg 
                565                 570                 575     


Gln Asn Gln Ser Thr Val Ala Val His Ser His Glu Pro Leu Leu Ser 
            580                 585                 590         


Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Thr 
        595                 600                 605             


Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly 
    610                 615                 620                 


Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Thr Leu 
625                 630                 635     


<210>  207
<211>  2123
<212>  DNA
<213>  Homo sapiens

<400>  207
caagagttgg taagctcgct gcagtgggtg gagagaggcc tctagacttc agtttcagtt     60

tcctggctct gggcagcagc aagaattcct ctgcctccca tcctaccatt cactgtcttg    120

ccggcagcca gctgagagca atgggaaatg gggagtccca gctgtcctcg gtgcctgctc    180

agaagctggg ttggtttatc caggaatacc tgaagcccta cgaagaatgt cagacactga    240

tcgacgagat ggtgaacacc atctgtgacg tcctgcagga acccgaacag ttccccctgg    300

tgcagggagt ggccataggt ggctcctatg gacggaaaac agtcttaaga ggcaactccg    360

atggtaccct tgtcctcttc ttcagtgact taaaacaatt ccaggatcag aagagaagcc    420

aacgtgacat cctcgataaa actggggata agctgaagtt ctgtctgttc acgaagtggt    480

tgaaaaacaa tttcgagatc cagaagtccc ttgatgggtt caccatccag gtgttcacaa    540

aaaatcagag aatctctttc gaggtgctgg ccgccttcaa cgctctgagt aagcattgct    600

gggtgtcagg agagaaaagc caaagaagcg ggtgccagac agctctgtgc aacctctagg    660

ccatgagtgg gatagatacc actgctgctt taaaaaatgg gagaccatag accctcagga    720

gagaagaatc ccttctaccc tggactcgct ctcttctctg gaactaactt ctcccccata    780

ccctgattgt ctttggagaa aatgttctgg attctagaat ctaaggcaga gccttttaag    840

ccatactgta cacataaatc acctggaacc ttgttaaaat gcagatcctg actcaggagg    900

tctgagttag agcccaggat ttcatatttc tagccagctc catgatgagc tgctggtccg    960

cagatcatgc ttgcaggttt tgaccagagt cagtgttggt tagagtaaga ggatgaggca   1020

gacatctggg aaaagtccag ctggggcaag catttgaagt ctgccttcct accaggtcaa   1080

aatcaaggca acgaccttcc atagataact atcaaagctt gagggggtgc cttgaaccca   1140

actcctaaat ccctaagacc tgcccacctc ttgtgtctcc tgtctcagca aacattccca   1200

cactcttgca tattgttaaa gtaacctctg cttaccaggc ttctggttta ataaaagatg   1260

gctagagtga ctccatctta aagcaagtag ctaggcactc aaaaggaacc tacaggctta   1320

atacttgggt ctgaaaatag ccacagtcta agctgaccac caattataat tgcagaatat   1380

ttaaggccat acaaaacatc tcccactaag cctacaaaat gtccaggtgt cctaaaagtt   1440

cagcccactt aaaggcagca ttaatgagca ggtttaggtt gaaggattaa tggtcatcaa   1500

taccactgtt aagaagaaaa ttcttggcca aattgaattt aatggagttt aactgagcag   1560

acaattcaca aatctagaag cctcctgagc cagagtaggt tcagagagtc ttgaacacag   1620

ccacgtggtg gaagaagatt tatggacagg aaaaggaaaa tgatgtactg aaaatgaaag   1680

tgaggtacag aaacagccag actggttata gctcagcatt ggccttattt gaacgagatt   1740

tgaacagttg gccacctttg attggccgaa actcagtgat tggcacaaga gtaggttgca   1800

gtctgtttac acatcctttt aggttatagt tcaccatgta cagagaaatt ttaggccaaa   1860

cttaaaatat gtaaggaggc agctttaggc taaacttgat ttaacagcac caataccccc   1920

tacctttagt gagcacatct gcacattcca attttaatga cagctcctta gaatttctta   1980

tcaacgaaga cactaacaaa gaatggcgca ttcctccttc tcctttctga ggatgcccta   2040

ccctgtaaca aagtcgtttc taataaattt gcttctttca ccataaaaaa aaaaaaaaaa   2100

aaaaaaaaaa aaaaaaaaaa aaa                                           2123


<210>  208
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Gly Asn Gly Glu Ser Gln Leu Ser Ser Val Pro Ala Gln Lys Leu 
1               5                   10                  15      


Gly Trp Phe Ile Gln Glu Tyr Leu Lys Pro Tyr Glu Glu Cys Gln Thr 
            20                  25                  30          


Leu Ile Asp Glu Met Val Asn Thr Ile Cys Asp Val Leu Gln Glu Pro 
        35                  40                  45              


Glu Gln Phe Pro Leu Val Gln Gly Val Ala Ile Gly Gly Ser Tyr Gly 
    50                  55                  60                  


Arg Lys Thr Val Leu Arg Gly Asn Ser Asp Gly Thr Leu Val Leu Phe 
65                  70                  75                  80  


Phe Ser Asp Leu Lys Gln Phe Gln Asp Gln Lys Arg Ser Gln Arg Asp 
                85                  90                  95      


Ile Leu Asp Lys Thr Gly Asp Lys Leu Lys Phe Cys Leu Phe Thr Lys 
            100                 105                 110         


Trp Leu Lys Asn Asn Phe Glu Ile Gln Lys Ser Leu Asp Gly Phe Thr 
        115                 120                 125             


Ile Gln Val Phe Thr Lys Asn Gln Arg Ile Ser Phe Glu Val Leu Ala 
    130                 135                 140                 


Ala Phe Asn Ala Leu Ser Lys His Cys Trp Val Ser Gly Glu Lys Ser 
145                 150                 155                 160 


Gln Arg Ser Gly Cys Gln Thr Ala Leu Cys Asn Leu 
                165                 170         


<210>  209
<211>  1763
<212>  DNA
<213>  Homo sapiens

<400>  209
tagctggatt ccagccattg ctgcagctgc tccacagccc ttttcaggac ccaaacaacc     60

gcagccgctg ttcccaggat ggtgatccgt gtatatattg catcttcctc tggctctaca    120

gcgattaaga agaaacaaca agatgtgctt ggtttcctag aagccaacaa aataggattt    180

gaagaaaaag atattgcagc caatgaagag aatcggaagt ggatgagaga aaatgtacct    240

gaaaatagtc gaccagccac aggttacccc ctgccacctc agattttcaa tgaaagccag    300

tatcgcgggg actatgatgc cttctttgaa gccagagaaa ataatgcagt gtatgccttc    360

ttaggcttga cagccccacc tggttcaaag gaagcagaag tgcaagcaaa gcagcaagca    420

tgaaccttaa gcactgtgct ttaagcatcc tgaaaaatga gtctccattg cttttataaa    480

atagcagaat tagctttgct tcaaaagaaa taggcttaat gttgaaataa tagattagtt    540

gggttttcac atgcaaacat tcaaaatgaa tacaaaatta aaatttgaac attatggtga    600

ttatggtgag gagaatggga tattaacata aaattatatt aataagtaga tatcgtagaa    660

atagtgttgt tacctgccaa gccatcctgt atacaccaat gattttacaa agaaaacacc    720

cttccctcct tctgccatta ctatggcaac ttaagtgtat ctgcagctct acattaaaaa    780

ggagaaagag aaataacctg tctctcattc ctaagttgcc tcattaattt tcatgaacaa    840

gaatatgtac ctttttgatg ctatattact gcgattaaaa aagttcttgc aggtaatgtt    900

tatgtatagt taaacgttgt aatttcttat cgtaattata acattcccat tctttgtaga    960

tgaaactcta catatgaacc acagattttc tgagcttcta aatgtagcct ttcattgcac   1020

atttcagtga tcagaataga tatcctttta cacgcacaaa agcaatagat tcattcagtg   1080

gacaagttcc ttgtttaact acacagctat gatggaatca tatatccaag ttccttgcct   1140

cagtgaaata tgcatatgta tatcatgaag tgggatgcca agtaagctta aaatgcattc   1200

tctagcaaag agattagact tttaaataac tcttataaaa caggttggcg atcatttccc   1260

aagattggtt tcccttgagt ttttgttaaa acaaatctta gtagttttgc ccgtttaaaa   1320

caactcacaa tcgtaaatgc tactattcct aagatatctt acctttttat ttcagtttag   1380

ccatgtattg tatgagtgta ttagtctaag cagtgagaat cttttctatg cctctattcc   1440

agcaaaaagt agaagtatca aataaaaagg gcaactttta aaatattaag cctgaagact   1500

tctaaaaaga caagaaacat ggcctaaata accaacatag atttacatag taagtttcac   1560

actaccttat taccaaaagc aaacacctct tactttaaac tacattatca tgtatatcta   1620

ttgtatgctg gtctttactt tttgccaaaa tcaacatata atgaagagat gcctttgttt   1680

gatgagattc aaacttgatg ctatgcttta aaataaactc agtactttta gaaacataaa   1740

aaaaaaaaaa aaaaaaaaaa aaa                                           1763


<210>  210
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Val Ile Arg Val Tyr Ile Ala Ser Ser Ser Gly Ser Thr Ala Ile 
1               5                   10                  15      


Lys Lys Lys Gln Gln Asp Val Leu Gly Phe Leu Glu Ala Asn Lys Ile 
            20                  25                  30          


Gly Phe Glu Glu Lys Asp Ile Ala Ala Asn Glu Glu Asn Arg Lys Trp 
        35                  40                  45              


Met Arg Glu Asn Val Pro Glu Asn Ser Arg Pro Ala Thr Gly Tyr Pro 
    50                  55                  60                  


Leu Pro Pro Gln Ile Phe Asn Glu Ser Gln Tyr Arg Gly Asp Tyr Asp 
65                  70                  75                  80  


Ala Phe Phe Glu Ala Arg Glu Asn Asn Ala Val Tyr Ala Phe Leu Gly 
                85                  90                  95      


Leu Thr Ala Pro Pro Gly Ser Lys Glu Ala Glu Val Gln Ala Lys Gln 
            100                 105                 110         


Gln Ala 
        


<210>  211
<211>  2312
<212>  DNA
<213>  Homo sapiens

<400>  211
gggcccggcg cgcggtagcg cgggcccctc agtgcacaat ggctagagca ggcggcggag     60

ccccaacccc acccagtgcg gagcgcgccg cgagccccgc cgcaagctga gcgcctccgc    120

ccgccaggcg cgccggcgcc gggccatgta ctcggggaac cgcagcggcg gccacggcta    180

ctgggacggc ggcggggccg cgggcgctga ggggccggcg ccggcgggga cactgagccc    240

cgcgcccctc ttcagccccg gcacctacga gcgcctggcg ctgctgctgg gctccattgg    300

gctgctgggc gtcggcaaca acctgctggt gctcgtcctc tactacaagt tccagcggct    360

ccgcactccc actcacctcc tcctggtcaa catcagcctc agcgacctgc tggtgtccct    420

cttcggggtc acctttacct tcgtgtcctg cctgaggaac ggctgggtgt gggacaccgt    480

gggctgcgtg tgggacgggt ttagcggcag cctcttcgct tcgttgtgtg gaagatcttc    540

agacaattca agtgatcaag attttaaaat atgaaaagaa actggccaaa atgtgctttt    600

taatgatatt caccttcctg gtctgttgga tgccttatat cgtgatctgc ttcttggtgg    660

ttaatggtca tggtcacctg gtcactccaa caatatctat tgtttcgtac ctctttgcta    720

aatcgaacac tgtatacaat ccagtgattt atgtcttcat gatcagaaag tttcgaagat    780

cccttttgca gcttctgtgc ctccgactgc tgaggtgcca gaggcctgct aaagacctac    840

cagcagctgg aagtgaaatg cagatcagac ccattgtgat gtcacagaaa gatggggaca    900

ggccaaagaa aaaagtgact ttcaactctt cttccatcat ttttatcatc accagtgatg    960

aatcactgtc agttgacgac agcgacaaaa ccaatgggtc caaagttgat gtaatccaag   1020

ttcgtccttt gtaggaatga agaatggcaa cgaaagatgg ggccttaaat tggatgccac   1080

ttttggactt tcatcataag aagtgtctgg aatacccgtt ctatgtaata tcaacagaac   1140

cttgtggtcc agcaggaaat ccgaattgcc catatgctct tgggcctcag gaagaggttg   1200

aacaaaaaca aattctttta attcaacggg tgctttacat aatgaaaaaa ccacttgtgg   1260

cacacgatgg gcatctaaca tcatcatctt ctaatgtgtt ggagattttc atttcaaata   1320

tattttttaa attactctat tttccaaaac acgtaatgca tttttctcga aaatacctta   1380

ctgtaaaaat aactgtcgcg tacacatgtg tgaagtagct agaacatact gaattttttt   1440

tgtactgttg gactctattc agtgtcatgt cctatatctg atcaagttat caaggagata   1500

attctagaat gaaaaagaaa atcctcttgt tggaaacaaa agacgtttta tatgtgcagt   1560

atgacaaaga ggagtttcag agacaacttt gaatccttgt cagcctggag accagcacca   1620

gaggaatcta caaggcaaac tcccatatat ttgcttcccc caaattgctg cccctacaga   1680

ctcaaagctc tttttctttg ttttgttgtt tctctaaaaa tttactgttc tttgtcgatg   1740

ctatataagc cagggagttc taagacgcca gctctttgag atttgctcat tcccctgtat   1800

ttcccacata tatattacat atacccgcta ataaatttat gtttgttttt ctcttgtcaa   1860

tctgtctttt gttatagggg ccccagccaa ggaacctaaa gtgggtagaa ggaaaaatta   1920

ttttttcttt ccctacaaac tgaacatgga ttattagaac tcaaggtttt cattgacaat   1980

atagaaaaga aacactgaat cattttattt tattgcccaa tttttatttc ttatatgact   2040

ctagtgtttc atcttcataa ttaatcatgt ttgaaggatt tctgagtgac tcagcagcct   2100

gttaaagaag gatgaaccaa agaaaacatt tcactaaatg tgcttttaaa aatcaagtgt   2160

attgctggtt ctgctgcagt atgtagtcga agaataaatt agtaaattgc ttctgagggt   2220

ctgaaattga ataaagtaat ggctttgtat ttctataaaa gttgtctccc cttgtttcct   2280

ttccattctg gcacatgtag acatttaatt ta                                 2312


<210>  212
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15      


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30          


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45              


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60                  


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80  


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95      


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110         


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Ala Ser Leu Cys 
        115                 120                 125             


Gly Arg Ser Ser Asp Asn Ser Ser Asp Gln Asp Phe Lys Ile 
    130                 135                 140         


<210>  213
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  213
aggaagccga ctaggcgaat tcacttactg accggcctgg gctgctctga gacatggagg     60

aagccagtga aggtggagga aatgatcgtg tgcggaacct gcaaagtgag gtggagggag    120

ttaagaatat tatgacccag aatgtggagc ggatcctggc ccggggggaa aacttggaac    180

atctccgcaa caagacagag gatctggaag ccacatctga gcacttcaag acgacatcgc    240

agaaggtggc tcggaaattc tggtggaaga acgtgaagat gattgtcctt atctgcgtga    300

ttgtttttat catcatcctc ttcattgtgc tctttgccac tggtgccttc tcttaagtaa    360

cagggaacct ctcccacctg cccttctttt cagggacaac cctccataaa tgtgtgccaa    420

gagggtctcc tttcctgtct tcctctacag agaatgctgc tcggtcctcc tacccctctt    480

cccgaggccc tgctgccacg ttgtatgccc cagaaggtac cttggtcccc cggaaggaga    540

gaaaaaagag agatggactg tggctgcatt tcttgggtcc ttagagtggg ctggagagac    600

ctagagggcc cagcatgtgg ctgggaaact gttggtggcc agtgggtaat aaagaccttt    660

cagtatccct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                       702


<210>  214
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Glu Glu Ala Ser Glu Gly Gly Gly Asn Asp Arg Val Arg Asn Leu 
1               5                   10                  15      


Gln Ser Glu Val Glu Gly Val Lys Asn Ile Met Thr Gln Asn Val Glu 
            20                  25                  30          


Arg Ile Leu Ala Arg Gly Glu Asn Leu Glu His Leu Arg Asn Lys Thr 
        35                  40                  45              


Glu Asp Leu Glu Ala Thr Ser Glu His Phe Lys Thr Thr Ser Gln Lys 
    50                  55                  60                  


Val Ala Arg Lys Phe Trp Trp Lys Asn Val Lys Met Ile Val Leu Ile 
65                  70                  75                  80  


Cys Val Ile Val Phe Ile Ile Ile Leu Phe Ile Val Leu Phe Ala Thr 
                85                  90                  95      


Gly Ala Phe Ser 
            100 


<210>  215
<211>  1399
<212>  DNA
<213>  Homo sapiens

<400>  215
agtgtgaaat cttcagagaa gaatttctct ttagttcttt gcaagaaggt agagataaag     60

acactttttc aaaaatggca atggtatcag aattcctcaa gcaggcctgg tttattgaaa    120

atgaagagca ggaatatgtt caaactgtga agtcatccaa aggtggtccc ggatcagcgg    180

tgagccccta tcctaccttc aatccatcct cggatgtcgc tgccttgcat aaggccataa    240

tggttaaagg tgtggatgaa gcaaccatca ttgacattct aactaagcga aacaatgcac    300

agcgtcaaca gatcaaagca gcatatctcc aggaaacagg aaagcccctg gatgaaacac    360

ttaagaaagc ccttacaggt caccttgagg aggttgtttt agctctgcta aaaactccag    420

cgcaatttga tgctgatgaa cttcgtgctg ccatgaaggg ccttggaact gatgaagata    480

ctctaattga gattttggca tcaagaacta acaaagaaat cagagacatt aacagggtct    540

acagagagga actgaagaga gatctggcca aagacataac ctcagacaca tctggagatt    600

ttcggaacgc tttgctttct cttgctaagg gtgaccgatc tgaggacttt ggtgtgaatg    660

aagacttggc tgattcagat gccagggcct tgtatgaagc aggagaaagg agaaagggga    720

cagacgtaaa cgtgttcaat accatcctta ccaccagaag ctatccacaa cttcgcagag    780

tgtttcagaa atacaccaag tacagtaagc atgacatgaa caaagttctg gacctggagt    840

tgaaaggtga cattgagaaa tgcctcacag ctatcgtgaa gtgcgccaca agcaaaccag    900

ctttctttgc agagaagctt catcaagcca tgaaaggtgt tggaactcgc cataaggcat    960

tgatcaggat tatggtttcc cgttctgaaa ttgacatgaa tgatatcaaa gcattctatc   1020

agaagatgta tggtatctcc ctttgccaag ccatcctgga tgaaaccaaa ggagattatg   1080

agaaaatcct ggtggctctt tgtggaggaa actaaacatt cccttgatgg tctcaagcta   1140

tgatcagaag actttaatta tatattttca tcctataagc ttaaatagga aagtttcttc   1200

aacaggatta cagtgtagct acctacatgc tgaaaaatat agcctttaaa tcatttttat   1260

attataactc tgtataatag agataagtcc attttttaaa aatgttttcc ccaaaccata   1320

aaaccctata caagttgttc tagtaacaat acatgagaaa gatgtctatg tagctgaaaa   1380

taaaatgacg tcacaagac                                                1399


<210>  216
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  217
<211>  2521
<212>  DNA
<213>  Homo sapiens

<400>  217
aggagcttag agtggagttt acaggaatga atcactgatt agcggcaggc ctaagtgtgg     60

gcactgtcgc accacacacc cagatactac tccaggcacg ggcattaggg gctcccacag    120

gctggacagg ccttggactt tcctggttga accgtgaggc cgcggtgtca gtccacactc    180

cactgtgggt ggcgggttcg gccccgcgag gaggcgccgc tctcaaaccc cacggtcccg    240

cgcagcgaag aggcgaggcg gccgcggaag gcaggcgcag cccactcttc ccgagaggcc    300

ccgacatctc ccggataatc tggagctttc aaaatgtttg ccaaagcaac caggaatttt    360

cttagagaag ttgatgctga tggtgacctg attgcagtat caaatctgaa tgactctgat    420

aagttacagc ttctaagtct ggtgacaaaa aagaagagat tctggtgctg gcagagaccc    480

aagtaccagt ttttatccct cacccttggc gatgtactca tagaagacca atttccgagt    540

ccagtggtcg tggagtcgga ctttgtgaaa tacgagggca agtttgcaaa ccacgtgagt    600

ggaaccctgg agactgcact ggggaaggtc aagctgaacc tggggggcag cagccgcgta    660

gagagccagt cttcatttgg aaccctgagg aagcaggagg tggatttgca gcagctcatc    720

agagactctg ccgagagaac aataaatctg agaaaccctg tgctccagca ggtgctggaa    780

ggaaggaatg aggtcctgtg cgttttgaca cagaagatca cgacgatgca gaagtgtgtg    840

atctctgagc acatgcaggt cgaggagaag tgtggtggca tcgtgggcat ccagaccaag    900

acggtgcagg tgtcagcgac ggaggatggg aatgtcacca aggactccaa cgtggtgctg    960

gagatcccag ctgccaccac cattgcctac ggtgtcattg agttatacgt gaaactggac   1020

ggccagttcg agttctgcct tctccgaggg aagcaaggtg gcttcgagaa caagaagaga   1080

attgactctg tctacctgga ccccctggtc tttcgagagt ttgcattcat agacatgcca   1140

gatgctgcgc atgggatatc ttcccaggat ggaccattaa gtgttttaaa gcaagcgacc   1200

ctgctcctgg agaggaattt ccatccattt gcggagctgc ctgagccaca acagacagct   1260

ttgagtgaca tcttccaggc ggtcctattt gatgatgaac tactcatggt cctggaacca   1320

gtgtgcgatg acctggtcag cggcctctcg cccacagtgg cggtgctggg ggagctgaag   1380

ccccggcagc agcaggacct tgtggccttc ctgcagctgg tggggtgcag cttacagggt   1440

gggtgtccgg gccccgagga tgcaggcagc aagcagctgt ttatgacagc ctacttcttg   1500

gtcagtgccc tcgcagaaat gccagatagc gcagcagctc tgctgggcac ttgctgcaaa   1560

ctccagatca ttcccacact gtgccacttg cttcgtgctc tgtctgatga tggagtatct   1620

gatcttgaag acccaacctt gactcccctg aaagatacag aaaggtttgg gattgtgcag   1680

cgcttgtttg cctcagctga cattagtctg gagagactga agtcatctgt gaaagctgtc   1740

attctgaagg actctaaagt cttcccactg cttctttgta taaccctgaa tggactctgt   1800

gctttaggca gagaacattc atgatgtcat atgtgaacta gaagtacgtg ttactggcca   1860

aggctatttt tcagaactgt taaaggtcat atgcacgtta aaagttgacc aatgaaatga   1920

atttacagaa cagtttaaga agtggtgaca ttttgcatga tgaatgacct gacttttagc   1980

caccaggtac tctttaaaca gttttcctta tcagaggccc tcctgtgctg gtgacccagc   2040

atctgagtta ggttccagca tgtaaagagc tgggagggcg gagaattctt agcatacatt   2100

cagacgtttt ttctgcacaa taataagtcc atctgtcact tgcattccac tttttgttac   2160

atagaaagag tctgaccctt taatccaaaa ggtcttttta cattgtgaat gctgtgggaa   2220

ggcaatttct ctgcacacaa gaggctacgt tttggaagtg atgtatgtta tttgatgact   2280

gaaaatgaac tgtaaatgct cctagagtat attcctctgc tgaacaaaat taaacttcaa   2340

aaaaatctaa cagtaacaca cccctgcttg ggaccctagc tatatgcatt ttatgtgacc   2400

ttgccatgct tcagtgaaca tactaattct atgtctagca catgttgatt tcctatgtat   2460

tctgggtatt ctattaaagg aaactttgaa ctatgaaaaa aaaaaaaaaa aaaaaaaaaa   2520

a                                                                   2521


<210>  218
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Phe Ala Lys Ala Thr Arg Asn Phe Leu Arg Glu Val Asp Ala Asp 
1               5                   10                  15      


Gly Asp Leu Ile Ala Val Ser Asn Leu Asn Asp Ser Asp Lys Leu Gln 
            20                  25                  30          


Leu Leu Ser Leu Val Thr Lys Lys Lys Arg Phe Trp Cys Trp Gln Arg 
        35                  40                  45              


Pro Lys Tyr Gln Phe Leu Ser Leu Thr Leu Gly Asp Val Leu Ile Glu 
    50                  55                  60                  


Asp Gln Phe Pro Ser Pro Val Val Val Glu Ser Asp Phe Val Lys Tyr 
65                  70                  75                  80  


Glu Gly Lys Phe Ala Asn His Val Ser Gly Thr Leu Glu Thr Ala Leu 
                85                  90                  95      


Gly Lys Val Lys Leu Asn Leu Gly Gly Ser Ser Arg Val Glu Ser Gln 
            100                 105                 110         


Ser Ser Phe Gly Thr Leu Arg Lys Gln Glu Val Asp Leu Gln Gln Leu 
        115                 120                 125             


Ile Arg Asp Ser Ala Glu Arg Thr Ile Asn Leu Arg Asn Pro Val Leu 
    130                 135                 140                 


Gln Gln Val Leu Glu Gly Arg Asn Glu Val Leu Cys Val Leu Thr Gln 
145                 150                 155                 160 


Lys Ile Thr Thr Met Gln Lys Cys Val Ile Ser Glu His Met Gln Val 
                165                 170                 175     


Glu Glu Lys Cys Gly Gly Ile Val Gly Ile Gln Thr Lys Thr Val Gln 
            180                 185                 190         


Val Ser Ala Thr Glu Asp Gly Asn Val Thr Lys Asp Ser Asn Val Val 
        195                 200                 205             


Leu Glu Ile Pro Ala Ala Thr Thr Ile Ala Tyr Gly Val Ile Glu Leu 
    210                 215                 220                 


Tyr Val Lys Leu Asp Gly Gln Phe Glu Phe Cys Leu Leu Arg Gly Lys 
225                 230                 235                 240 


Gln Gly Gly Phe Glu Asn Lys Lys Arg Ile Asp Ser Val Tyr Leu Asp 
                245                 250                 255     


Pro Leu Val Phe Arg Glu Phe Ala Phe Ile Asp Met Pro Asp Ala Ala 
            260                 265                 270         


His Gly Ile Ser Ser Gln Asp Gly Pro Leu Ser Val Leu Lys Gln Ala 
        275                 280                 285             


Thr Leu Leu Leu Glu Arg Asn Phe His Pro Phe Ala Glu Leu Pro Glu 
    290                 295                 300                 


Pro Gln Gln Thr Ala Leu Ser Asp Ile Phe Gln Ala Val Leu Phe Asp 
305                 310                 315                 320 


Asp Glu Leu Leu Met Val Leu Glu Pro Val Cys Asp Asp Leu Val Ser 
                325                 330                 335     


Gly Leu Ser Pro Thr Val Ala Val Leu Gly Glu Leu Lys Pro Arg Gln 
            340                 345                 350         


Gln Gln Asp Leu Val Ala Phe Leu Gln Leu Val Gly Cys Ser Leu Gln 
        355                 360                 365             


Gly Gly Cys Pro Gly Pro Glu Asp Ala Gly Ser Lys Gln Leu Phe Met 
    370                 375                 380                 


Thr Ala Tyr Phe Leu Val Ser Ala Leu Ala Glu Met Pro Asp Ser Ala 
385                 390                 395                 400 


Ala Ala Leu Leu Gly Thr Cys Cys Lys Leu Gln Ile Ile Pro Thr Leu 
                405                 410                 415     


Cys His Leu Leu Arg Ala Leu Ser Asp Asp Gly Val Ser Asp Leu Glu 
            420                 425                 430         


Asp Pro Thr Leu Thr Pro Leu Lys Asp Thr Glu Arg Phe Gly Ile Val 
        435                 440                 445             


Gln Arg Leu Phe Ala Ser Ala Asp Ile Ser Leu Glu Arg Leu Lys Ser 
    450                 455                 460                 


Ser Val Lys Ala Val Ile Leu Lys Asp Ser Lys Val Phe Pro Leu Leu 
465                 470                 475                 480 


Leu Cys Ile Thr Leu Asn Gly Leu Cys Ala Leu Gly Arg Glu His Ser 
                485                 490                 495     


<210>  219
<211>  598
<212>  DNA
<213>  Homo sapiens

<400>  219
cagagtcact cctgccttca ccatgaagtc cagcggcctc ttccccttcc tggtgctgct     60

tgccctggga actctggcac cttgggctgt ggaaggctct ggaaagtcct tcaaagctgg    120

agtctgtcct cctaagaaat ctgcccagtg ccttagatac aagaaacctg agtgccagag    180

tgactggcag tgtccaggga agaagagatg ttgtcctgac acttgtggca tcaaatgcct    240

ggatcctgtt gacaccccaa acccaacaag gaggaagcct gggaagtgcc cagtgactta    300

tggccaatgt ttgatgctta acccccccaa tttctgtgag atggatggcc agtgcaagcg    360

tgacttgaag tgttgcatgg gcatgtgtgg gaaatcctgc gtttcccctg tgaaagcttg    420

attcctgcca tatggaggag gctctggagt cctgctctgt gtggtccagg tcctttccac    480

cctgagactt ggctccacca ctgatatcct cctttgggga aaggcttggc acacagcagg    540

ctttcaagaa gtgccagttg atcaatgaat aaataaacga gcctatttct ctttgcac      598


<210>  220
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Lys Ser Ser Gly Leu Phe Pro Phe Leu Val Leu Leu Ala Leu Gly 
1               5                   10                  15      


Thr Leu Ala Pro Trp Ala Val Glu Gly Ser Gly Lys Ser Phe Lys Ala 
            20                  25                  30          


Gly Val Cys Pro Pro Lys Lys Ser Ala Gln Cys Leu Arg Tyr Lys Lys 
        35                  40                  45              


Pro Glu Cys Gln Ser Asp Trp Gln Cys Pro Gly Lys Lys Arg Cys Cys 
    50                  55                  60                  


Pro Asp Thr Cys Gly Ile Lys Cys Leu Asp Pro Val Asp Thr Pro Asn 
65                  70                  75                  80  


Pro Thr Arg Arg Lys Pro Gly Lys Cys Pro Val Thr Tyr Gly Gln Cys 
                85                  90                  95      


Leu Met Leu Asn Pro Pro Asn Phe Cys Glu Met Asp Gly Gln Cys Lys 
            100                 105                 110         


Arg Asp Leu Lys Cys Cys Met Gly Met Cys Gly Lys Ser Cys Val Ser 
        115                 120                 125             


Pro Val Lys Ala 
    130         


<210>  221
<211>  1607
<212>  DNA
<213>  Homo sapiens

<400>  221
aatgactcct ttcggtaagt gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc     60

agcgtaggcg ggcgactcag atcccagcca gtggacttag cccctgtttg ctcctccgat    120

aactggggtg accttggtta atattcacca gcagcctccc ccgttgcccc tctggatcca    180

ctgcttaaat acggacgagg acagggccct gtctcctcag cttcaggcac caccactgac    240

ctgggacagt gaatcgacaa tgccgtcttc tgtctcgtgg ggcatcctcc tgctggcagg    300

cctgtgctgc ctggtccctg tctccctggc tgaggatccc cagggagatg ctgcccagaa    360

gacagataca tcccaccatg atcaggatca cccaaccttc aacaagatca cccccaacct    420

ggctgagttc gccttcagcc tataccgcca gctggcacac cagtccaaca gcaccaatat    480

cttcttctcc ccagtgagca tcgctacagc ctttgcaatg ctctccctgg ggaccaaggc    540

tgacactcac gatgaaatcc tggagggcct gaatttcaac ctcacggaga ttccggaggc    600

tcagatccat gaaggcttcc aggaactcct ccgtaccctc aaccagccag acagccagct    660

ccagctgacc accggcaatg gcctgttcct cagcgagggc ctgaagctag tggataagtt    720

tttggaggat gttaaaaagt tgtaccactc agaagccttc actgtcaact tcggggacac    780

cgaagaggcc aagaaacaga tcaacgatta cgtggagaag ggtactcaag ggaaaattgt    840

ggatttggtc aaggagcttg acagagacac agtttttgct ctggtgaatt acatcttctt    900

taaaggcaaa tgggagagac cctttgaagt caaggacacc gaggaagagg acttccacgt    960

ggaccaggtg accaccgtga aggtgcctat gatgaagcgt ttaggcatgt ttaacatcca   1020

gcactgtaag aagctgtcca gctgggtgct gctgatgaaa tacctgggca atgccaccgc   1080

catcttcttc ctgcctgatg aggggaaact acagcacctg gaaaatgaac tcacccacga   1140

tatcatcacc aagttcctgg aaaatgaaga cagaaggtct gccagcttac atttacccaa   1200

actgtccatt actggaacct atgatctgaa gagcgtcctg ggtcaactgg gcatcactaa   1260

ggtcttcagc aatggggctg acctctccgg ggtcacagag gaggcacccc tgaagctctc   1320

caaggccgtg cataaggctg tgctgaccat cgacgagaaa gggactgaag ctgctggggc   1380

catgttttta gaggccatac ccatgtctat cccccccgag gtcaagttca acaaaccctt   1440

tgtcttctta atgattgaac aaaataccaa gtctcccctc ttcatgggaa aagtggtgaa   1500

tcccacccaa aaataactgc ctctcgctcc tcaacccctc ccctccatcc ctggccccct   1560

ccctggatga cattaaagaa gggttgagct ggtccctgcc tgcaaaa                 1607


<210>  222
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  223
<211>  3614
<212>  DNA
<213>  Homo sapiens

<400>  223
gctacaagat gaccactgag gattacaaga agctgtgagt atgcaacgcc aggcacccta     60

caatatcagg cgcagctcta catcagggga caccgaggag gaggaggagg aggaggtggt    120

gccattctcc tcagatgaac agaaacggag gtcagaggct gcaagcggtg ttctgaggag    180

gacagctccc cgggagcact cctacgtcct gtcagcggcc aagaagagca ctggcagtcc    240

tacccaggag acacaggcac cgtttatcgc gaagagggtg gaggtggtgg aagaggacgg    300

gccttctgag aagagccagg acccacctgc tctggcaaga tccactcctg gctcaaacag    360

ctcaagaggt gaggaaattg tccgcctgca gatcctgaca cccagggcag gactccgcct    420

ggtggcccca gacgtggaag gcatgagctc cagtgccact tcagtctctg ctgtccctgc    480

tgataggaag agcaacagca cagcagccca ggaggatgca aaggcagacc caaagggggc    540

cttggctgat tgtgagggga aggatgtacc caccagggtc ggagaggcct ggcaggagag    600

gcctggagct ccaagaggtg gccaaggaga cccagctgta cccgctcagc aacctgcaga    660

tcccagcacc ccagagcggc agagcagccc cagcggatct gagcaacttg tcagacgaga    720

gagttgtggc agtagcgtgt tgactgattt tgaggggaag gatgtggcca ccaaggtcgg    780

agaggcctgg caggacaggc ctagagcccc aagaggtggc caaggagacc cagctgtacc    840

cactcagcaa cctgcagatc ccagtacccc agaacagcag aacagcccca gcggatctga    900

gcaattcgtc agacgagaga gctgcaccag cagggtgagg agcccctcga gctgcatggt    960

cactgttact gtcactgcca catctgagca gcctcacatt tatattccag cccccgcaag   1020

tgaattggac tccagctcta ccaccaaagg gattctcttc gtgaaggagt acgtgaatgc   1080

tagtgaagtg tcttctggga agccagtatc tgcacgctat agcaacgtca gcagcattga   1140

ggactcattc gccatggaga agaagcctcc atgtggcagc actccatact ctgagaggac   1200

aactggaggg atctgtactt actgcaaccg tgagatccga gactgtccaa agattaccct   1260

agaacatctt ggtatctgct gccatgaata ttgctttaag tgtgggattt gcagtaaacc   1320

gatgggcgat ctcctggatc agatcttcat tcaccgtgac accattcact gtgggaaatg   1380

ctatgagaag ctcttctagc gaccccccac cgccaggctg atcagaagct gatgactcgt   1440

ggacaaattt ggctgtcccc agttttgccc caagttgctg tctccccttc cctcacctcc   1500

tccctccctg tttgatttct tcatgctttt gcccttctca agttgaagtt gcatacatcc   1560

aatatcgtat cttaatgatg ctatgataat tgcttgtgtg tgtagcttct tgtagcttag   1620

aaagcgcttt atgcccatga tgtcatttca ggctcaacca aagaggatca aacaggaatt   1680

ccatcttggc ttccctaaga cagattggct ttctaatgag tttaagtggg cagaagtgta   1740

gggttcagtg tgtcctgact cccttgaggc ttataatggg ccaagttgaa gactgttgat   1800

gatccctggt gggtaaattg cagacatcaa atgctaggga ttggcatagg ctagtgttta   1860

gcttgtctat ttgccatatc tattttttta aatttccata cacttgtaaa agtagttagt   1920

tgcttttgat tgagttatat agcagttttt catttggtct tccactcacc gttcactata   1980

tttgagtgtt cccttacagg tatgttggca tgtgttggaa aatttacaca attaggttta   2040

aattcagtag gatgtgattt tgggggtgga ctgatcaaag tgatatctgt gtctgttgga   2100

atcttgatag ctgattaatt tgccctcaat tctgctccct gaacttcaca cataaatctt   2160

cccaagtggg ttttagggtg tatagatccc agcaggatta aggaagtgga aaagcagcta   2220

acatttcttg aggctctacc acatagcagg cactgtcaca gagtaatggc attaatcccc   2280

ataataatcc tgtgaaggtg atattctcat cccatcttag acatgaggat attggaactc   2340

agagaggtgg ctattgcatt gcgcagaacg ctacagagcc catgctcttc ccagagcagc   2400

acccacaaaa gcaagcattg attttgtgct cagtgtgtgc caagcactgt gcagagggta   2460

cacagttcct gccaggttaa caccctccct tcaggcctcc caaaggcata ggcttgcaaa   2520

gagcagaagg tgtgaaatca cactcttcct ctgggcatcc tggatccctg aattatcccc   2580

ccccccatga agtacttcaa gggccaagct gcccctttcc ctcctctccg cccatgaaaa   2640

tgcctccaaa ctgagatgct ttcagctgag aacagatttg actcacagac attaccaaag   2700

aggagcttgt gaatccagga aaagctccag ggggctagct gatctgagca gagagctttc   2760

agtgacccat tttcctgtct agactctgcc ttaagctagt ggcaactgct ggggccccag   2820

gtacttggga catggaaact cgttggatgg ctgggcagat gtaagcctgt ccatgcagtc   2880

agccgatcct ctgctcaggt tcagctggac tctgccatct gtgggcccag catcactctg   2940

taagttcctt gaaaggaaga acaaccttag agtatttctg atacaaaatg agggcctctg   3000

ctcttgattt aattataaaa tgtctacgtc tttctccagt ttctgagccc tatgcacatt   3060

ggcttgtggg cttgttcttc ctgccaaatg atcagagagg gaacattcca tttatttgta   3120

gtggatttcc tctggagggc atgtacccac actaaatacc aactgctctt cctcagctgt   3180

agtccccaac atcagacttg gcacgtggtg gacactaaca cacaggcact caatgaatga   3240

gtgaaggaaa taaaagtcac cccccgttgg tgagaaggtg cctatccccc tgagtcctca   3300

gtgcaggacc agtggatgaa aggcaaggta aagaggccca agataggctg gcttcccccg   3360

ttcaaggtat agtctgcctt taagggagtt ttagaaccaa catgcaagac attgaaagaa   3420

atcttgcaag agccattatt gacttagatc caaaacagcc tctctcatgt ctaaaaaggc   3480

acagaatttt gcagatctga ggaagaggga tgcattacct ttttgcttct tttcaattgc   3540

ttagtgtttc taatcatact taatccacac taatgtgcgc aattataata aatgctaaaa   3600

tatcaaaaaa aaaa                                                     3614


<210>  224
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Gln Arg Gln Ala Pro Tyr Asn Ile Arg Arg Ser Ser Thr Ser Gly 
1               5                   10                  15      


Asp Thr Glu Glu Glu Glu Glu Glu Glu Val Val Pro Phe Ser Ser Asp 
            20                  25                  30          


Glu Gln Lys Arg Arg Ser Glu Ala Ala Ser Gly Val Leu Arg Arg Thr 
        35                  40                  45              


Ala Pro Arg Glu His Ser Tyr Val Leu Ser Ala Ala Lys Lys Ser Thr 
    50                  55                  60                  


Gly Ser Pro Thr Gln Glu Thr Gln Ala Pro Phe Ile Ala Lys Arg Val 
65                  70                  75                  80  


Glu Val Val Glu Glu Asp Gly Pro Ser Glu Lys Ser Gln Asp Pro Pro 
                85                  90                  95      


Ala Leu Ala Arg Ser Thr Pro Gly Ser Asn Ser Ser Arg Gly Glu Glu 
            100                 105                 110         


Ile Val Arg Leu Gln Ile Leu Thr Pro Arg Ala Gly Leu Arg Leu Val 
        115                 120                 125             


Ala Pro Asp Val Glu Gly Met Ser Ser Ser Ala Thr Ser Val Ser Ala 
    130                 135                 140                 


Val Pro Ala Asp Arg Lys Ser Asn Ser Thr Ala Ala Gln Glu Asp Ala 
145                 150                 155                 160 


Lys Ala Asp Pro Lys Gly Ala Leu Ala Asp Cys Glu Gly Lys Asp Val 
                165                 170                 175     


Pro Thr Arg Val Gly Glu Ala Trp Gln Glu Arg Pro Gly Ala Pro Arg 
            180                 185                 190         


Gly Gly Gln Gly Asp Pro Ala Val Pro Ala Gln Gln Pro Ala Asp Pro 
        195                 200                 205             


Ser Thr Pro Glu Arg Gln Ser Ser Pro Ser Gly Ser Glu Gln Leu Val 
    210                 215                 220                 


Arg Arg Glu Ser Cys Gly Ser Ser Val Leu Thr Asp Phe Glu Gly Lys 
225                 230                 235                 240 


Asp Val Ala Thr Lys Val Gly Glu Ala Trp Gln Asp Arg Pro Arg Ala 
                245                 250                 255     


Pro Arg Gly Gly Gln Gly Asp Pro Ala Val Pro Thr Gln Gln Pro Ala 
            260                 265                 270         


Asp Pro Ser Thr Pro Glu Gln Gln Asn Ser Pro Ser Gly Ser Glu Gln 
        275                 280                 285             


Phe Val Arg Arg Glu Ser Cys Thr Ser Arg Val Arg Ser Pro Ser Ser 
    290                 295                 300                 


Cys Met Val Thr Val Thr Val Thr Ala Thr Ser Glu Gln Pro His Ile 
305                 310                 315                 320 


Tyr Ile Pro Ala Pro Ala Ser Glu Leu Asp Ser Ser Ser Thr Thr Lys 
                325                 330                 335     


Gly Ile Leu Phe Val Lys Glu Tyr Val Asn Ala Ser Glu Val Ser Ser 
            340                 345                 350         


Gly Lys Pro Val Ser Ala Arg Tyr Ser Asn Val Ser Ser Ile Glu Asp 
        355                 360                 365             


Ser Phe Ala Met Glu Lys Lys Pro Pro Cys Gly Ser Thr Pro Tyr Ser 
    370                 375                 380                 


Glu Arg Thr Thr Gly Gly Ile Cys Thr Tyr Cys Asn Arg Glu Ile Arg 
385                 390                 395                 400 


Asp Cys Pro Lys Ile Thr Leu Glu His Leu Gly Ile Cys Cys His Glu 
                405                 410                 415     


Tyr Cys Phe Lys Cys Gly Ile Cys Ser Lys Pro Met Gly Asp Leu Leu 
            420                 425                 430         


Asp Gln Ile Phe Ile His Arg Asp Thr Ile His Cys Gly Lys Cys Tyr 
        435                 440                 445             


Glu Lys Leu Phe 
    450         


<210>  225
<211>  2683
<212>  DNA
<213>  Homo sapiens

<400>  225
cagtcggctc ggaattggac ttgggaggcg cggtgaggag tcaggcttaa aacttgttgg     60

aggggagtaa ccagcctgct cctctcgctc tcctcctcgt ctgcgccgcg tttcagagag    120

aaaattcctg ttccaagaga aaataaggca acatcaatga aggagagaag agccagccag    180

aaattatcca gcaaatctat catggatcct aatcagaacg tgaaatgcaa gatagttgtg    240

gtgggagaca gtcagtgtgg aaaaactgcg ctgctccatg tcttcgccaa ggactgcttc    300

cccgagaatt acgttcctac agtgtttgag aattacacgg ccagttttga aatcgacaca    360

caaagaatag agttgagcct gtgggacact tcgggttctc cttactatga caatgtccgc    420

cccctctctt accctgattc ggatgctgtg ctgatttgct ttgacatcag tagaccagag    480

accctggaca gtgtcctcaa aaagtggaaa ggtgaaatcc aggaattttg tccaaatacc    540

aaaatgctct tggtcggctg caagtctgat ctgcggacag atgttagtac attagtagag    600

ctctccaatc acaggcagac gccagtgtcc tatgaccagg gggcaaatat ggccaaacag    660

attggagcag ctacttatat cgaatgctca gctttacagt cggaaaatag cgtcagagac    720

atttttcacg ttgccacctt ggcatgtgta aataagacaa ataaaaacgt taagcggaac    780

aaatcacaga gagccacaaa gcggatttca cacatgccta gcagaccaga actctcggca    840

gttgctacgg acttacgaaa ggacaaagcg aagagctgca ctgtgatgtg aatctttcat    900

tatctttaat gaagacaaag gaatctagtg taaaaaacaa cagcaaacaa aaaggtgaag    960

tctaaatgaa gtgcacagcc aaagtcatgt ataccagagg cttaggaggc gtttgagagg   1020

atactcatct ttttggaatc ctgaccttag gttcggcatg tagaccaagt gatgagaagt   1080

gaatacatgg aagagttttt aagtgtgact tgaaaaatat gccaaaaaat gagagataca   1140

aatgagctag aggaagatga ggggggatgc gagtacctcc aagaagaaaa atcacactct   1200

gaatggtgct tgcatttttg ggtttttttt ttttgttata atctattcat ggatctccac   1260

tttgatttaa tttttaaatg ttttaatctc ctttacaaaa agtatacgtt aatataccgt   1320

cctcaagggg gaactggcac tgtgacctta gcatttagtt ttctagagga tgtgatctaa   1380

tttctttcta gctcatcatt aaaaaggaaa ttgtatcagg acccatggga tatatccaga   1440

ggcaaacttt atgaggcttt gaaatcttgc cttcctgaag atagctgagt aggatggttc   1500

taaggaaagc ctttgcaatc ttgcaagatt tgtagaccag cactacaaag atcgcataga   1560

tcaaatagga aaaaaaatgt cgatttttat tcagtctgat ggttctgttc ttcattgtga   1620

ttgtcattaa aaagtggtaa attgctcaat gtaatatttt tgtgcgctgt ttagaagttg   1680

tgtgattttt tgccatcgtt gataaaaatg caaagtcaaa taaaaggtgt cttggtttga   1740

tgtcatagaa tgatccaagg agagaaaaaa ggtagttact gttttcacca gaaaaggtaa   1800

tgagtgaagg aaagaatagt agcagaaagc acagtttgtg agtaaagctg tctggaatta   1860

agttaccaaa aatacaaagc aaaaggacta ttattttggg ttgaagctcc aaaactgaca   1920

gcatctgata atctgttggt ttatttcact tttcattaaa tgaacattga tgagagaaga   1980

tgccacttac ccaagcttta gagaatccct agtggaagat tatatgataa actttcagtc   2040

ctgacataac actagggcat ttctagagtg tcattgctaa aacctcactg aacagatgca   2100

gccaaggtct gtgttcagca cttggtctct gttgttacgt aaaataataa gcatttaaaa   2160

tagtttacag atatttttga ccagttcctt ttagagattc tttcagagaa gaaaccagat   2220

ctgacctgtt tattgttggc gcttgttgaa aacgagcttt ctttcccatg atagtgcttc   2280

gtttttgaag tgttgaagct gtgctcccct taaatcgtgg caggagagat taaggtaatt   2340

acaacactca gttctatgtc ttacaagcac tttgtcttgt ctctgcaaga aaattcgatt   2400

ccagtcattt cccataaaat acagacattt taccaacata atatgctttg attgatgcag   2460

cattatgctt tgggcagtat tacaaaatag ctggcgagtg ctttctgtat ttaaatattg   2520

taaaaagaaa ataagttata actgttataa agcagaactt ttgttgcatt ttttaaactg   2580

ttgaagtcac tgtgtatgtt tgtttggtca atgtttccgc agtatttatt aaaacatact   2640

ttttttttct tcaaataaaa aagtaaccat gtctttgtct aaa                     2683


<210>  226
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Lys Glu Arg Arg Ala Ser Gln Lys Leu Ser Ser Lys Ser Ile Met 
1               5                   10                  15      


Asp Pro Asn Gln Asn Val Lys Cys Lys Ile Val Val Val Gly Asp Ser 
            20                  25                  30          


Gln Cys Gly Lys Thr Ala Leu Leu His Val Phe Ala Lys Asp Cys Phe 
        35                  40                  45              


Pro Glu Asn Tyr Val Pro Thr Val Phe Glu Asn Tyr Thr Ala Ser Phe 
    50                  55                  60                  


Glu Ile Asp Thr Gln Arg Ile Glu Leu Ser Leu Trp Asp Thr Ser Gly 
65                  70                  75                  80  


Ser Pro Tyr Tyr Asp Asn Val Arg Pro Leu Ser Tyr Pro Asp Ser Asp 
                85                  90                  95      


Ala Val Leu Ile Cys Phe Asp Ile Ser Arg Pro Glu Thr Leu Asp Ser 
            100                 105                 110         


Val Leu Lys Lys Trp Lys Gly Glu Ile Gln Glu Phe Cys Pro Asn Thr 
        115                 120                 125             


Lys Met Leu Leu Val Gly Cys Lys Ser Asp Leu Arg Thr Asp Val Ser 
    130                 135                 140                 


Thr Leu Val Glu Leu Ser Asn His Arg Gln Thr Pro Val Ser Tyr Asp 
145                 150                 155                 160 


Gln Gly Ala Asn Met Ala Lys Gln Ile Gly Ala Ala Thr Tyr Ile Glu 
                165                 170                 175     


Cys Ser Ala Leu Gln Ser Glu Asn Ser Val Arg Asp Ile Phe His Val 
            180                 185                 190         


Ala Thr Leu Ala Cys Val Asn Lys Thr Asn Lys Asn Val Lys Arg Asn 
        195                 200                 205             


Lys Ser Gln Arg Ala Thr Lys Arg Ile Ser His Met Pro Ser Arg Pro 
    210                 215                 220                 


Glu Leu Ser Ala Val Ala Thr Asp Leu Arg Lys Asp Lys Ala Lys Ser 
225                 230                 235                 240 


Cys Thr Val Met 
                


<210>  227
<211>  4168
<212>  DNA
<213>  Homo sapiens

<400>  227
aagacttagg aagactggtg gatgcgtttg ggttgtagct aggctttttc ttttctttct     60

cttttaaaac acatctagac aaggaaaaaa caagcctcgg atctgatttt tcactcctcg    120

ttcttgtgct tggttcttac tgtgtttgtg tattttaaag gcgagaagac gaggggaaca    180

aaaccagctg gatccatcca tcaccgtggg tggttttaat ttttcgtttt ttctcgttat    240

ttttttttaa acaaccactc ttcacaatga acaaactgta tatcggaaac ctcagcgaga    300

acgccgcccc ctcggaccta gaaagtatct tcaaggacgc caagatcccg gtgtcgggac    360

ccttcctggt gaagactggc tacgcgttcg tggactgccc ggacgagagc tgggccctca    420

aggccatcga ggcgctttca ggtaaaatag aactgcacgg gaaacccata gaagttgagc    480

actcggtccc aaaaaggcaa aggattcgga aacttcagat acgaaatatc ccgcctcatt    540

tacagtggga ggtgctggat agtttactag tccagtatgg agtggtggag agctgtgagc    600

aagtgaacac tgactcggaa actgcagttg taaatgtaac ctattccagt aaggaccaag    660

ctagacaagc actagacaaa ctgaatggat ttcagttaga gaatttcacc ttgaaagtag    720

cctatatccc tgatgaaatg gccgcccagc aaaacccctt gcagcagccc cgaggtcgcc    780

gggggcttgg gcagaggggc tcctcaaggc aggggtctcc aggatccgta tccaagcaga    840

aaccatgtga tttgcctctg cgcctgctgg ttcccaccca atttgttgga gccatcatag    900

gaaaagaagg tgccaccatt cggaacatca ccaaacagac ccagtctaaa atcgatgtcc    960

accgtaaaga aaatgcgggg gctgctgaga agtcgattac tatcctctct actcctgaag   1020

gcacctctgc ggcttgtaag tctattctgg agattatgca taaggaagct caagatataa   1080

aattcacaga agagatcccc ttgaagattt tagctcataa taactttgtt ggacgtctta   1140

ttggtaaaga aggaagaaat cttaaaaaaa ttgagcaaga cacagacact aaaatcacga   1200

tatctccatt gcaggaattg acgctgtata atccagaacg cactattaca gttaaaggca   1260

atgttgagac atgtgccaaa gctgaggagg agatcatgaa gaaaatcagg gagtcttatg   1320

aaaatgatat tgcttctatg aatcttcaag cacatttaat tcctggatta aatctgaacg   1380

ccttgggtct gttcccaccc acttcaggga tgccacctcc cacctcaggg cccccttcag   1440

ccatgactcc tccctacccg cagtttgagc aatcagaaac ggagactgtt catctgttta   1500

tcccagctct atcagtcggt gccatcatcg gcaagcaggg ccagcacatc aagcagcttt   1560

ctcgctttgc tggagcttca attaagattg ctccagcgga agcaccagat gctaaagtga   1620

ggatggtgat tatcactgga ccaccagagg ctcagttcaa ggctcaggga agaatttatg   1680

gaaaaattaa agaagaaaac tttgttagtc ctaaagaaga ggtgaaactt gaagctcata   1740

tcagagtgcc atcctttgct gctggcagag ttattggaaa aggaggcaaa acggtgaatg   1800

aacttcagaa tttgtcaagt gcagaagttg ttgtccctcg tgaccagaca cctgatgaga   1860

atgaccaagt ggttgtcaaa ataactggtc acttctatgc ttgccaggtt gcccagagaa   1920

aaattcagga aattctgact caggtaaagc agcaccaaca acagaaggct ctgcaaagtg   1980

gaccacctca gtcaagacgg aagtaaaggc tcaggaaaca gcccaccaca gaggcagatg   2040

ccaaaccaaa gacagattgc ttaaccaaca gatgggcgct gaccccctat ccagaatcac   2100

atgcacaagt ttttacctag ccagttgttt ctgaggacca ggcaactttt gaactcctgt   2160

ctctgtgaga atgtatactt tatgctctct gaaatgtatg acacccagct ttaaaacaaa   2220

caaacaaaca aacaaaaaaa gggtggggga gggagggaaa gagaagagct ctgcacttcc   2280

ctttgttgta gtctcacagt ataacagata ttctaattct tcttaatatt cccccataat   2340

gccagaaatt ggcttaatga tgctttcact aaattcatca aatagattgc tcctaaatcc   2400

aattgttaaa attggatcag aataattatc acaggaactt aaatgttaag ccattagcat   2460

agaaaaactg ttctcagttt tatttttacc taacactaac atgagtaacc taagggaagt   2520

gctgaatggt gttggcaggg gtattaaacg tgcattttta ctcaactacc tcaggtattc   2580

agtaatacaa tgaaaagcaa aattgttcct tttttttgaa aattttatat actttataat   2640

gatagaagtc caaccgtttt ttaaaaaata aatttaaaat ttaacagcaa tcagctaaca   2700

ggcaaattaa gatttttact tctggctggt gacagtaaag ctggaaaatt aatttcaggg   2760

ttttttgagg cttttgacac agttattagt taaatcaaat gttcaaaaat acggagcagt   2820

gcctagtatc tggagagcag cactaccatt tattctttca tttatagttg ggaaagtttt   2880

tgacggtact aacaaagtgg tcgcaggaga ttttggaacg gctggtttaa atggcttcag   2940

gagacttcag ttttttgttt agctacatga ttgaatgcat aataaatgct ttgtgcttct   3000

gactatcaat acctaaagaa agtgcatcag tgaagagatg caagactttc aactgactgg   3060

caaaaagcaa gctttagctt gtcttatagg atgcttagtt tgccactaca cttcagacca   3120

atgggacagt catagatggt gtgacagtgt ttaaacgcaa caaaaggcta catttccatg   3180

gggccagcac tgtcatgagc ctcactaagc tattttgaag atttttaagc actgataaat   3240

taaaaaaaaa aaattagact ccaccttaag tagtaaagta taacaggatt tctgtatact   3300

gtgcaatcag ttctttgaaa aaaaagtcaa aagatagaga atacaagaaa agtttttggg   3360

atataatttg aatgactgtg aaaacatatg acctttgata acgaactcat ttgctcactc   3420

cttgacagca aagcccagta cgtacaattg tgttgggtgt gggtggtctc caaggccacg   3480

ctgctctctg aattgatttt ttgagttttg tttgtaagat gatcacagtc atgttacact   3540

gatctaaagg acatatatat aaccctttaa aaaaaaaatc actgcctcat tcttatttca   3600

agatgaattt ctatacagac tagatgtttt tctgaagatc aattagacat tttgaaaatg   3660

atttaaagtg ttttccttaa tgttctctga aaacaagttt cttttgtagt tttaaccaaa   3720

aaagtgccct ttttgtcact ggattctcct agcattcatg attttttttt catacaatga   3780

attaaaattg ctaaaatcat ggactggctt tctggttgga tttcaggtaa gatgtgttta   3840

aggccagagc ttttctcagt atttgatttt tttccccaat atttgatttt ttaaaaatat   3900

acacataggt gctgcattta tatctgctgg tttaaattct gtcatatttc acttctagcc   3960

ttttagtatg gcaaatcata ttttactttt acttaagcat ttgtaatttg gagtatctgg   4020

tactagctaa gaaataattc tataattgag ttttgtactc accatatatg gatcattcct   4080

catgtataat gtgccccaaa tgcagcttca ttttccagat accttgacgc agaataaatt   4140

ttttcatcat ttaggtgcaa aaaaaaaa                                      4168


<210>  228
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Asn Lys Leu Tyr Ile Gly Asn Leu Ser Glu Asn Ala Ala Pro Ser 
1               5                   10                  15      


Asp Leu Glu Ser Ile Phe Lys Asp Ala Lys Ile Pro Val Ser Gly Pro 
            20                  25                  30          


Phe Leu Val Lys Thr Gly Tyr Ala Phe Val Asp Cys Pro Asp Glu Ser 
        35                  40                  45              


Trp Ala Leu Lys Ala Ile Glu Ala Leu Ser Gly Lys Ile Glu Leu His 
    50                  55                  60                  


Gly Lys Pro Ile Glu Val Glu His Ser Val Pro Lys Arg Gln Arg Ile 
65                  70                  75                  80  


Arg Lys Leu Gln Ile Arg Asn Ile Pro Pro His Leu Gln Trp Glu Val 
                85                  90                  95      


Leu Asp Ser Leu Leu Val Gln Tyr Gly Val Val Glu Ser Cys Glu Gln 
            100                 105                 110         


Val Asn Thr Asp Ser Glu Thr Ala Val Val Asn Val Thr Tyr Ser Ser 
        115                 120                 125             


Lys Asp Gln Ala Arg Gln Ala Leu Asp Lys Leu Asn Gly Phe Gln Leu 
    130                 135                 140                 


Glu Asn Phe Thr Leu Lys Val Ala Tyr Ile Pro Asp Glu Met Ala Ala 
145                 150                 155                 160 


Gln Gln Asn Pro Leu Gln Gln Pro Arg Gly Arg Arg Gly Leu Gly Gln 
                165                 170                 175     


Arg Gly Ser Ser Arg Gln Gly Ser Pro Gly Ser Val Ser Lys Gln Lys 
            180                 185                 190         


Pro Cys Asp Leu Pro Leu Arg Leu Leu Val Pro Thr Gln Phe Val Gly 
        195                 200                 205             


Ala Ile Ile Gly Lys Glu Gly Ala Thr Ile Arg Asn Ile Thr Lys Gln 
    210                 215                 220                 


Thr Gln Ser Lys Ile Asp Val His Arg Lys Glu Asn Ala Gly Ala Ala 
225                 230                 235                 240 


Glu Lys Ser Ile Thr Ile Leu Ser Thr Pro Glu Gly Thr Ser Ala Ala 
                245                 250                 255     


Cys Lys Ser Ile Leu Glu Ile Met His Lys Glu Ala Gln Asp Ile Lys 
            260                 265                 270         


Phe Thr Glu Glu Ile Pro Leu Lys Ile Leu Ala His Asn Asn Phe Val 
        275                 280                 285             


Gly Arg Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Ile Glu Gln 
    290                 295                 300                 


Asp Thr Asp Thr Lys Ile Thr Ile Ser Pro Leu Gln Glu Leu Thr Leu 
305                 310                 315                 320 


Tyr Asn Pro Glu Arg Thr Ile Thr Val Lys Gly Asn Val Glu Thr Cys 
                325                 330                 335     


Ala Lys Ala Glu Glu Glu Ile Met Lys Lys Ile Arg Glu Ser Tyr Glu 
            340                 345                 350         


Asn Asp Ile Ala Ser Met Asn Leu Gln Ala His Leu Ile Pro Gly Leu 
        355                 360                 365             


Asn Leu Asn Ala Leu Gly Leu Phe Pro Pro Thr Ser Gly Met Pro Pro 
    370                 375                 380                 


Pro Thr Ser Gly Pro Pro Ser Ala Met Thr Pro Pro Tyr Pro Gln Phe 
385                 390                 395                 400 


Glu Gln Ser Glu Thr Glu Thr Val His Leu Phe Ile Pro Ala Leu Ser 
                405                 410                 415     


Val Gly Ala Ile Ile Gly Lys Gln Gly Gln His Ile Lys Gln Leu Ser 
            420                 425                 430         


Arg Phe Ala Gly Ala Ser Ile Lys Ile Ala Pro Ala Glu Ala Pro Asp 
        435                 440                 445             


Ala Lys Val Arg Met Val Ile Ile Thr Gly Pro Pro Glu Ala Gln Phe 
    450                 455                 460                 


Lys Ala Gln Gly Arg Ile Tyr Gly Lys Ile Lys Glu Glu Asn Phe Val 
465                 470                 475                 480 


Ser Pro Lys Glu Glu Val Lys Leu Glu Ala His Ile Arg Val Pro Ser 
                485                 490                 495     


Phe Ala Ala Gly Arg Val Ile Gly Lys Gly Gly Lys Thr Val Asn Glu 
            500                 505                 510         


Leu Gln Asn Leu Ser Ser Ala Glu Val Val Val Pro Arg Asp Gln Thr 
        515                 520                 525             


Pro Asp Glu Asn Asp Gln Val Val Val Lys Ile Thr Gly His Phe Tyr 
    530                 535                 540                 


Ala Cys Gln Val Ala Gln Arg Lys Ile Gln Glu Ile Leu Thr Gln Val 
545                 550                 555                 560 


Lys Gln His Gln Gln Gln Lys Ala Leu Gln Ser Gly Pro Pro Gln Ser 
                565                 570                 575     


Arg Arg Lys 
            


<210>  229
<211>  2786
<212>  DNA
<213>  Homo sapiens

<400>  229
agcactctcc agcctctcac cgcaaaatta cacaccccag tacaccagca gaggaaactt     60

ataacctcgg gaggcgggtc cttcccctca gtgcggtcac atacttccag aagagcggac    120

cagggctgct gccagcacct gccactcaga gcgcctctgt cgctgggacc cttcagaact    180

ctctttgctc acaagttacc aaaaaaaaaa gagccaacat gttggtattg ctggctggta    240

tctttgtggt ccacatcgct actgttatta tgctatttgt tagcaccatt gccaatgtct    300

ggttggtttc caatacggta gatgcatcag taggtctttg gaaaaactgt accaacatta    360

gctgcagtga cagcctgtca tatgccagtg aagatgccct caagacagtg caggccttca    420

tgattctctc tatcatcttc tgtgtcattg ccctcctggt cttcgtgttc cagctcttca    480

ccatggagaa gggaaaccgg ttcttcctct caggggccac cacactggtg tgctggctgt    540

gcattcttgt gggggtgtcc atctacacta gtcattatgc gaatcgtgat ggaacgcagt    600

atcaccacgg ctattcctac atcctgggct ggatctgctt ctgcttcagc ttcatcatcg    660

gcgttctcta tctggtcctg agaaagaaat aaggccggac gagttcatgg ggatctgggg    720

ggtggggagg aggaagccgt tgaatctggg agggaagtgg aggttgctgt acaggaaaaa    780

ccgagatagg ggagggggga gggggaagca aaggggggag gtcaaatccc aaaccattac    840

tgaggggatt ctctactgcc aagcccctgc cctggggaga aagtagttgg ctagtacttt    900

gatgctccct tgatggggtc cagagagcct ccctgcagcc accagacttg gcctccagct    960

gttcttagtg acacacactg tctggggccc catcagctgc cacaacacca gccccacttc   1020

tgggtcatgc actgaggtcc acagacctac tgcactgagt taaaatagcg gtacaagttc   1080

tggcaagagc agatactgtc tttgtgctga atacgctaag cctggaagcc atcctgccct   1140

tctgacccaa agcaaaacat cacattccag tctgaagtgc ctactggggg gctttggcct   1200

gtgagccatt gtccctcttt ggaacagata tttagctctg tggaattcag tgacaaaatg   1260

ggaggaggaa agagagtttg taaggtcatg ctggtgggtt agctaaacca agaaggagac   1320

cttttcacaa tggaaaacct gggggatggt cagagcccag tcgagacctc acacacggct   1380

gtccctcatg gagacctcat gccatggtct ttgctaggcc tcttgctgaa agccaaggca   1440

gctcttctgg agtttctcta aagtcactag tgaacaattc ggtggtaaaa gtaccacaca   1500

aactatggga tccaaggggc agtcttgcaa cagtgccatg ttagggttat gtttttagga   1560

ttcccctcaa tgcagtcagt gtttctttta agtatacaac aggagagaga tggacatggc   1620

tcattgtagc acaatcctat tactcttcct ctaacatttt tgaggaagtt ttgtctaatt   1680

atcaatattg aggatcaggg ctcctaggct cagtggtagc tctggcttag acaccacctg   1740

gagtgatcac ctcttgggga ccctgcctat cccacttcac aggtgaggca tggcaattct   1800

ggaagctgat taaaacacac ataaaccaaa accaaacaac aggcccttgg gtgaaaggtg   1860

ctatataatt gtgaagtatt aagcctaccg tatttcagcc atgataagaa cagagtgcct   1920

gcattcccag gaaaatacga aaatcccatg agataaataa aaatataggt gatgggcaga   1980

tcttttcttt aaaataaaaa agcaaaaact cttgtggtac ctagtcagat ggtagacgag   2040

ctgtctgctg ccgcaggagc acctctatac aggacttaga agtagtatgt tattcctggt   2100

taagcaggca ttgctttgcc ctggagcagc tattttaagc catctcagat tctgtctaaa   2160

ggggtttttt gggaagacgt tttctttatc gccctgagaa gatctacccc agggagaatc   2220

tgagacatct tgcctacttt tctttattag ctttctcctc atccatttct tttatacctt   2280

tcctttttgg ggagttgtta tgccatgatt tttggtattt atgtaaaagg attattacta   2340

attctatttc tctatgttta ttctagttaa ggaaatgttg agggcaagcc accaaattac   2400

ctaggctgag gttagagaga ttggccagca aaaactgtgg gaagatgaac tttgtcatta   2460

tgatttcatt atcacatgat tatagaaggc tgtcttagtg caaaaaacat acttacattt   2520

cagacatatc caaagggaat actcacattt tgttaagaag ttgaactatg actggagtaa   2580

accatgtatt cccttatctt ttactttttt tctgtgacat ttatgtctca tgtaatttgc   2640

attactctgg tggattgttc tagtactgta ttgggcttct tcgttaatag attatttcat   2700

atactataat tgtaaatatt ttgatacaaa tgtttataac tctagggata taaaaacaga   2760

ttctgattcc cttcaaaaaa aaaaaa                                        2786


<210>  230
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Leu Val Leu Leu Ala Gly Ile Phe Val Val His Ile Ala Thr Val 
1               5                   10                  15      


Ile Met Leu Phe Val Ser Thr Ile Ala Asn Val Trp Leu Val Ser Asn 
            20                  25                  30          


Thr Val Asp Ala Ser Val Gly Leu Trp Lys Asn Cys Thr Asn Ile Ser 
        35                  40                  45              


Cys Ser Asp Ser Leu Ser Tyr Ala Ser Glu Asp Ala Leu Lys Thr Val 
    50                  55                  60                  


Gln Ala Phe Met Ile Leu Ser Ile Ile Phe Cys Val Ile Ala Leu Leu 
65                  70                  75                  80  


Val Phe Val Phe Gln Leu Phe Thr Met Glu Lys Gly Asn Arg Phe Phe 
                85                  90                  95      


Leu Ser Gly Ala Thr Thr Leu Val Cys Trp Leu Cys Ile Leu Val Gly 
            100                 105                 110         


Val Ser Ile Tyr Thr Ser His Tyr Ala Asn Arg Asp Gly Thr Gln Tyr 
        115                 120                 125             


His His Gly Tyr Ser Tyr Ile Leu Gly Trp Ile Cys Phe Cys Phe Ser 
    130                 135                 140                 


Phe Ile Ile Gly Val Leu Tyr Leu Val Leu Arg Lys Lys 
145                 150                 155         


<210>  231
<211>  2805
<212>  DNA
<213>  Homo sapiens

<400>  231
cgggtctgat agtccctacc tgtcaggact ggtgttagga tgagataatg tttgtgaact     60

gtaaacatat ataaacgtgt gctactgtga gaactggaac aaagaagaga gggagtgaga    120

gaaatcaagg gagggctggg gctgggaaag aacgaaaagg gagtcgcgta tagaggagag    180

gcgacagtcg cgagccacac tttgcaatga aactctttag actttctgcc gggagagcgg    240

cccagacgcg ccaggtctgt agcaggaggc cgcgagggcg ggtccccaga agcctacagg    300

tgagtatcgg ttctcccctt cccggctttc ggtccggagg aggcgggagc agcttccctg    360

ttctgatcct atcgcgggcg gcgcagggcc ggcttggcct tccgtgggac ggggaggggg    420

gcgggatgtg tcacccaaat accagtgggg acggtcggtg gtggaaccag ccgggcaggt    480

cgggtagagt ataagagccg gagggagcgg ccggggcgca gacgcctgca gaccatccca    540

gacgccggag cccgagcccc gacgagtccc cgcgcctcat ccgcccgcgt ccggtccgcg    600

ttcctccgcc ccaccatggc tcggggcccc ggcctcgcgc cgccaccgct gcggctgccg    660

ctgctgctgc tggtgctggc ggcggtgacc ggccacacgg ccgcgcagga caactgcacg    720

tgtcccacca acaagatgac cgtgtgcagc cccgacggcc ccggcggccg ctgccagtgc    780

cgcgcgctgg gctcgggcat ggcggtcgac tgctccacgc tgacctccaa gtgtctgctg    840

ctcaaggcgc gcatgagcgc ccccaagaac gcccgcacgc tggtgcggcc gagtgagcac    900

gcgctcgtgg acaacgatgg cctctacgac cccgactgcg accccgaggg ccgcttcaag    960

gcgcgccagt gcaaccagac gtcggtgtgc tggtgcgtga actcggtggg cgtgcgccgc   1020

acggacaagg gcgacctgag cctacgctgc gatgagctgg tgcgcaccca ccacatcctc   1080

attgacctgc gccaccgccc caccgccggc gccttcaacc actcagacct ggacgccgag   1140

ctgaggcggc tcttccgcga gcgctatcgg ctgcacccca agttcgtggc ggccgtgcac   1200

tacgagcagc ccaccatcca gatcgagctg cggcagaaca cgtctcagaa ggccgccggt   1260

gaagtggata tcggcgatgc cgcctactac ttcgagaggg acatcaaggg cgagtctcta   1320

ttccagggcc gcggcggcct ggacttgcgc gtgcgcggag aacccctgca ggtggagcgc   1380

acgctcatct attacctgga cgagattccc ccgaagttct ccatgaagcg cctcaccgcc   1440

ggcctcatcg ccgtcatcgt ggtggtcgtg gtggccctcg tcgccggcat ggccgtcctg   1500

gtgatcacca accggagaaa gtcggggaag tacaagaagg tggagatcaa ggaactgggg   1560

gagttgagaa aggaaccgag cttgtaggta cccggcgggg caggggatgg ggtggggtac   1620

cggatttcgg tatcgtccca gacccaagtg agtcacgctt cctgattcct cggcgcaaag   1680

gagacgttta tcctttcaaa ttcctgcctt ccccctccct tttgcgcaca caccaggttt   1740

aatagatcct ggcctcaggg tctcctttct ttctcacttc tgtcttgagg gaagcatttc   1800

taaaatgtat cccctttcgg tccaacaaca ggaaacctga ctggggcagt gaaggaaggg   1860

atggcacagc gttatgtgta aaaaacaagt atctgtatga caacccggga tcgtttgcaa   1920

gtaactgaat ccattgcgac attgtgaagg cttaaatgag tttagatggg aaatagcgtt   1980

gttatcgcct tgggtttaaa ttatttgatg agttccactt gtatcatggc ctacccgagg   2040

agaagaggag tttgttaact gggcctatgt agtagcctca tttaccatcg tttgtattac   2100

tgaccacata tgcttgtcac tgggaaagaa gcctgtttca gctgcctgaa cgcagtttgg   2160

atgtctttga ggacagacat tgcccggaaa ctcagtctat ttattcttca gcttgccctt   2220

actgccactg atattggtaa tgttcttttt tgtaaaatgt ttgtacatat gttgtctttg   2280

ataatgttgc tgtaattttt taaaataaaa cacgaattta ataaaatatg ggaaaggcac   2340

aaaccagaag tcggcatttg tgaaaagtcc ctccagattt ctatcacttt ggtctctaat   2400

ttcccaagac ttgtattttt tttttatttc aaattataac actttttttt cccccagaag   2460

tgggtgtttc atgttgctac tctggtgtgt cccaagatat cctaactggc cagtgtaaat   2520

gctattcttt ctaaataaga ttatttggaa acttccttca aactgcagga gggcgagctc   2580

tgagggcacg agaagctaaa actagctgct tttgatgaaa aagagtgcca gtctttggtc   2640

atctctaaac aaggcttatc accaatggag acagaaaact ctagttcaag agctgtacct   2700

cctttgaatc ccagccctac tcgaaataag tggtactatt tccatttagc ctttgagcaa   2760

atcacttaac tcaaaggcgt tgtggctcta agattaaacg acttt                   2805


<210>  232
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Ala Arg Gly Pro Gly Leu Ala Pro Pro Pro Leu Arg Leu Pro Leu 
1               5                   10                  15      


Leu Leu Leu Val Leu Ala Ala Val Thr Gly His Thr Ala Ala Gln Asp 
            20                  25                  30          


Asn Cys Thr Cys Pro Thr Asn Lys Met Thr Val Cys Ser Pro Asp Gly 
        35                  40                  45              


Pro Gly Gly Arg Cys Gln Cys Arg Ala Leu Gly Ser Gly Met Ala Val 
    50                  55                  60                  


Asp Cys Ser Thr Leu Thr Ser Lys Cys Leu Leu Leu Lys Ala Arg Met 
65                  70                  75                  80  


Ser Ala Pro Lys Asn Ala Arg Thr Leu Val Arg Pro Ser Glu His Ala 
                85                  90                  95      


Leu Val Asp Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp Pro Glu Gly 
            100                 105                 110         


Arg Phe Lys Ala Arg Gln Cys Asn Gln Thr Ser Val Cys Trp Cys Val 
        115                 120                 125             


Asn Ser Val Gly Val Arg Arg Thr Asp Lys Gly Asp Leu Ser Leu Arg 
    130                 135                 140                 


Cys Asp Glu Leu Val Arg Thr His His Ile Leu Ile Asp Leu Arg His 
145                 150                 155                 160 


Arg Pro Thr Ala Gly Ala Phe Asn His Ser Asp Leu Asp Ala Glu Leu 
                165                 170                 175     


Arg Arg Leu Phe Arg Glu Arg Tyr Arg Leu His Pro Lys Phe Val Ala 
            180                 185                 190         


Ala Val His Tyr Glu Gln Pro Thr Ile Gln Ile Glu Leu Arg Gln Asn 
        195                 200                 205             


Thr Ser Gln Lys Ala Ala Gly Glu Val Asp Ile Gly Asp Ala Ala Tyr 
    210                 215                 220                 


Tyr Phe Glu Arg Asp Ile Lys Gly Glu Ser Leu Phe Gln Gly Arg Gly 
225                 230                 235                 240 


Gly Leu Asp Leu Arg Val Arg Gly Glu Pro Leu Gln Val Glu Arg Thr 
                245                 250                 255     


Leu Ile Tyr Tyr Leu Asp Glu Ile Pro Pro Lys Phe Ser Met Lys Arg 
            260                 265                 270         


Leu Thr Ala Gly Leu Ile Ala Val Ile Val Val Val Val Val Ala Leu 
        275                 280                 285             


Val Ala Gly Met Ala Val Leu Val Ile Thr Asn Arg Arg Lys Ser Gly 
    290                 295                 300                 


Lys Tyr Lys Lys Val Glu Ile Lys Glu Leu Gly Glu Leu Arg Lys Glu 
305                 310                 315                 320 


Pro Ser Leu 
            


<210>  233
<211>  3127
<212>  DNA
<213>  Homo sapiens

<400>  233
gccgggcagt gggcaggtat ggctgagggc gtgtgagcgc cgagcgctaa gggccgccgc     60

caccatgcca gggggcgcag gcgccgcccg gctctgcttg ctggcgtttg ccctgcagcc    120

cctccggccg cgggcggcgc gggagcctgg atggacaagt aaaggaagtg aggaaggcag    180

ccccaagctg cagcatgaac ttatcatacc tcagtggaag acttcagaaa gccccgtgag    240

agaaaagcat ccactcaaag ctgagctcag ggtaatggct gaggggcgag aactgatcct    300

ggacctggag aagaatgagc aactttttgc tccttcctac acagaaaccc attatacttc    360

aagtggtaac cctcaaacca ccacacggaa attggaggat cactgctttt accacggcac    420

ggtgagggag acagaactgt ccagcgtcac gctcagcact tgccgaggaa ttagaggact    480

gattacggtg agcagcaacc tcagctacgt catcgagccc ctccctgaca gcaagggcca    540

acaccttatt tacagatctg aacatctcaa gccgcccccg ggaaactgtg ggttcgagca    600

ctccaagccc accaccaggg actgggctct tcagtttaca caacagacca agaagcgacc    660

tcgcaggatg aaaagggaag atttaaactc catgaagtat gtggagcttt acctcgtggc    720

tgattattta gagtttcaga agaatcgacg agaccaggac gccaccaaac acaagctcat    780

agagatcgcc aactatgttg ataagtttta ccgatccttg aacatccgga ttgctctcgt    840

gggcttggaa gtgtggaccc acgggaacat gtgtgaagtt tcagagaatc catattctac    900

cctctggtcc tttctcagtt ggaggcgcaa gctgcttgcc cagaagtacc atgacaacgc    960

ccaattaatc acgggcatgt ccttccacgg caccaccatc ggcctggccc ccctcatggc   1020

catgtgctct gtgtaccagt ctggaggagt caacatggac cactccgaga atgccattgg   1080

cgtggctgcc accatggccc acgagatggg ccacaacttt ggcatgaccc atgattctgc   1140

agattgctgc tcggccagtg cggctgatgg tgggtgcatc atggcagctg ccactgggca   1200

cccctttccc aaagtgttca atggatgcaa caggagggag ctggacaggt atctgcagtc   1260

aggtggtgga atgtgtctct ccaacatgcc agacaccagg atgttgtatg gaggccggag   1320

gtgtgggaac gggtatctgg aagatgggga agagtgtgac tgtggagaag aagaggaatg   1380

taacaacccc tgctgcaatg cctctaattg taccctgagg ccgggggcgg agtgtgctca   1440

cggctcctgc tgccaccagt gtaagctgtt ggctcctggg accctgtgcc gcgagcaggc   1500

caggcagtgt gacctcccgg agttctgtac gggcaagtct ccccactgcc ctaccaactt   1560

ctaccagatg gatggtaccc cctgtgaggg cggccaggcc tactgctaca acggcatgtg   1620

cctcacctac caggagcagt gccagcagct gtggggaccc ggagcccgac ctgcccctga   1680

cctctgcttc gagaaggtga atgtggcagg agacaccttt ggaaactgtg gaaaggacat   1740

gaatggtgaa cacaggaagt gcaacatgag agatgcgaag tgtgggaaga tccagtgtca   1800

gagctctgag gcccggcccc tggagtccaa cgcggtgccc attgacacca ctatcatcat   1860

gaatgggagg cagatccagt gccggggcac ccacgtctac cgaggtcctg aggaggaggg   1920

tgacatgctg gacccagggc tggtgatgac tggaaccaag tgtggctaca accatatttg   1980

ctttgagggg cagtgcagga acacctcctt ctttgaaact gaaggctgtg ggaagaagtg   2040

caatggccat ggggtctgta acaacaacca gaactgccac tgcctgccgg gctgggcccc   2100

gcccttctgc aacacaccgg gccacggggg cagtatcgac agtgggccta tgccccctga   2160

gagtgtgggt cctgtggtag ctggagtgtt ggtggccatc ttggtgctgg cggtcctcat   2220

gctgatgtac tactgctgca gacagaacaa caaactaggc caactcaagc cctcagctct   2280

cccttccaag ctgaggcaac agttcagttg tcccttcagg gtttctcaga acagcgggac   2340

tggtcatgcc aacccaactt tcaagctgca gacgccccag ggcaagcgaa aggtgatcaa   2400

cactccggaa atcctgcgga agccctccca gcctcctccc cggccccctc cagattatct   2460

gcgtggtggg tccccacctg caccactgcc agctcacctg agcagggctg ctaggaactc   2520

cccagggccc gggtctcaaa tagagaggac ggagtcgtcc aggaggcctc ctccaagccg   2580

gccaattccc cccgcaccaa attgcatcgt ttcccaggac ttctccaggc ctcggccgcc   2640

ccagaaggca ctcccggcaa acccagtgcc aggccgcagg agcctcccca ggccaggagg   2700

tgcatcccca ctgcggcccc ctggtgctgg ccctcagcag tcccggcctc tggcagcact   2760

tgccccaaag gtgagtccac gggaagccct caaggtgaaa gctggtacca gagggctcca   2820

ggggggcagg tgtagagttg agaaaacaaa gcaattcatg cttcttgtgg tctggactga   2880

acttccagaa caaaagccaa gggcaaaaca ttcatgtttc ttggtgcccg cttgactgtg   2940

gagttttggc ttcatgtgaa aggtgattct tagaatcctg agctgtggtg gcttcagtcc   3000

tgcccctgca cctgacctgg ggagggaccc tgagcaagtc cctcttgagt ctgtttcctc   3060

atttgtacag aggctatgat gagcagtagt accagcccca tcaggttgtt gtgaagagca   3120

aggaagt                                                             3127


<210>  234
<211>  956
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala 
1               5                   10                  15      


Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Ser 
            20                  25                  30          


Lys Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile 
        35                  40                  45              


Pro Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu 
    50                  55                  60                  


Lys Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp 
65                  70                  75                  80  


Leu Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His 
                85                  90                  95      


Tyr Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp 
            100                 105                 110         


His Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val 
        115                 120                 125             


Thr Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser 
    130                 135                 140                 


Asn Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His 
145                 150                 155                 160 


Leu Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly 
                165                 170                 175     


Phe Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr 
            180                 185                 190         


Gln Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn 
        195                 200                 205             


Ser Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe 
    210                 215                 220                 


Gln Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu 
225                 230                 235                 240 


Ile Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile 
                245                 250                 255     


Ala Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val 
            260                 265                 270         


Ser Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg 
        275                 280                 285             


Lys Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly 
    290                 295                 300                 


Met Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met 
305                 310                 315                 320 


Cys Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn 
                325                 330                 335     


Ala Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe 
            340                 345                 350         


Gly Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp 
        355                 360                 365             


Gly Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val 
    370                 375                 380                 


Phe Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly 
385                 390                 395                 400 


Gly Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly 
                405                 410                 415     


Gly Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp 
            420                 425                 430         


Cys Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn 
        435                 440                 445             


Cys Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His 
    450                 455                 460                 


Gln Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg 
465                 470                 475                 480 


Gln Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro 
                485                 490                 495     


Thr Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala 
            500                 505                 510         


Tyr Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln 
        515                 520                 525             


Leu Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys 
    530                 535                 540                 


Val Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn 
545                 550                 555                 560 


Gly Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile 
                565                 570                 575     


Gln Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro 
            580                 585                 590         


Ile Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly 
        595                 600                 605             


Thr His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro 
    610                 615                 620                 


Gly Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe 
625                 630                 635                 640 


Glu Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly 
                645                 650                 655     


Lys Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His 
            660                 665                 670         


Cys Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly 
        675                 680                 685             


Gly Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val 
    690                 695                 700                 


Val Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu 
705                 710                 715                 720 


Met Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro 
                725                 730                 735     


Ser Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg 
            740                 745                 750         


Val Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu 
        755                 760                 765             


Gln Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu 
    770                 775                 780                 


Arg Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg 
785                 790                 795                 800 


Gly Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala 
                805                 810                 815     


Arg Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser 
            820                 825                 830         


Arg Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile 
        835                 840                 845             


Val Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro 
    850                 855                 860                 


Ala Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala 
865                 870                 875                 880 


Ser Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu 
                885                 890                 895     


Ala Ala Leu Ala Pro Lys Val Ser Pro Arg Glu Ala Leu Lys Val Lys 
            900                 905                 910         


Ala Gly Thr Arg Gly Leu Gln Gly Gly Arg Cys Arg Val Glu Lys Thr 
        915                 920                 925             


Lys Gln Phe Met Leu Leu Val Val Trp Thr Glu Leu Pro Glu Gln Lys 
    930                 935                 940                 


Pro Arg Ala Lys His Ser Cys Phe Leu Val Pro Ala 
945                 950                 955     


<210>  235
<211>  2254
<212>  DNA
<213>  Homo sapiens

<400>  235
aatcgaaagt agactctttt ctgaagcatt tcctgggatc agcctgacca cgctccatac     60

tgggagaggc ttctgggtca aaggaccagt ctgcagaggg atcctgtggc tggaagcgag    120

gaggctccac acggccgttg cagctaccgc agccaggatc tgggcatcca ggcacggcca    180

tgacccctcc gaggctcttc tgggtgtggc tgctggttgc aggaacccaa ggcgtgaacg    240

atggtgacat gcggctggcc gatgggggcg ccaccaacca gggccgcgtg gagatcttct    300

acagaggcca gtggggcact gtgtgtgaca acctgtggga cctgactgat gccagcgtcg    360

tctgccgggc cctgggcttc gagaacgcca cccaggctct gggcagagct gccttcgggc    420

aaggatcagg ccccatcatg ctggacgagg tccagtgcac gggaaccgag gcctcactgg    480

ccgactgcaa gtccctgggc tggctgaaga gcaactgcag gcacgagaga gacgctggtg    540

tggtctgcac caatgaaacc aggagcaccc acaccctgga cctctccagg gagctctcgg    600

aggcccttgg ccagatcttt gacagccagc ggggctgcga cctgtccatc agcgtgaatg    660

tgcagggcga ggacgccctg ggcttctgtg gccacacggt catcctgact gccaacctgg    720

aggcccaggc cctgtggaag gagccgggca gcaatgtcac catgagtgtg gatgctgagt    780

gtgtgcccat ggtcagggac cttctcaggt acttctactc ccgaaggatt gacatcaccc    840

tgtcgtcagt caagtgcttc cacaagctgg cctctgccta tggggccagg cagctgcagg    900

gctactgcgc aagcctcttt gccatcctcc tcccccagga cccctcgttc cagatgcccc    960

tggacctgta tgcctatgca gtggccacag gggacgccct gctggagaag ctctgcctac   1020

agttcctggc ctggaacttc gaggccttga cgcaggccga ggcctggccc agtgtcccca   1080

cagacctgct ccaactgctg ctgcccagga gcgacctggc ggtgcccagc gagctggccc   1140

tactgaaggc cgtggacacc tggagctggg gggagcgtgc ctcccatgag gaggtggagg   1200

gcttggtgga gaagatccgc ttccccatga tgctccctga ggagctcttt gagctgcagt   1260

tcaacctgtc cctgtactgg agccacgagg ccctgttcca gaagaagact ctgcaggccc   1320

tggaattcca cactgtgccc ttccagttgc tggcccggta caaaggcctg aacctcaccg   1380

aggataccta caagccccgg atttacacct cgcccacctg gagtgccttt gtgacagaca   1440

gttcctggag tgcacggaag tcacaactgg tctatcagtc cagacggggg cctttggtca   1500

aatattcttc tgattacttc caagccccct ctgactacag atactacccc taccagtcct   1560

tccagactcc acaacacccc agcttcctct tccaggacaa gagggtgtcc tggtccctgg   1620

tctacctccc caccatccag agctgctgga actacggctt ctcctgctcc tcggacgagc   1680

tccctgtcct gggcctcacc aagtctggcg gctcagatcg caccattgcc tacgaaaaca   1740

aagccctgat gctctgcgaa gggctcttcg tggcagacgt caccgatttc gagggctgga   1800

aggctgcgat tcccagtgcc ctggacacca acagctcgaa gagcacctcc tccttcccct   1860

gcccggcagg gcacttcaac ggcttccgca cggtcatccg ccccttctac ctgaccaact   1920

cctcaggtgt ggactagacg cgtggccaag ggtggtgaga accggagaac cccaggacgc   1980

cctcactgca ggctcccctc ctcggcttcc ttcctctctg caatgacctt caacaaccgg   2040

ccaccagatg tcgccctact cacctgaggc tcagcttcaa gaaattactg gaaggcttcc   2100

actagggtcc accaggagtt ctcccaccac ctcaccagtt tccaggtggt aagcaccagg   2160

aggccctcga ggttgctctg gatcccccca cagcccctgg tcagtctgcc cttgtcactg   2220

gtctgaggtc attaaaatta cattgaggtt ccta                               2254


<210>  236
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                85                  90                  95      


Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
            100                 105                 110         


Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg 
        115                 120                 125             


Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly 
    130                 135                 140                 


Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn 
145                 150                 155                 160 


Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu 
                165                 170                 175     


Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn 
            180                 185                 190         


Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu 
        195                 200                 205             


Leu Arg Tyr Phe Tyr Ser Arg Arg Ile Asp Ile Thr Leu Ser Ser Val 
    210                 215                 220                 


Lys Cys Phe His Lys Leu Ala Ser Ala Tyr Gly Ala Arg Gln Leu Gln 
225                 230                 235                 240 


Gly Tyr Cys Ala Ser Leu Phe Ala Ile Leu Leu Pro Gln Asp Pro Ser 
                245                 250                 255     


Phe Gln Met Pro Leu Asp Leu Tyr Ala Tyr Ala Val Ala Thr Gly Asp 
            260                 265                 270         


Ala Leu Leu Glu Lys Leu Cys Leu Gln Phe Leu Ala Trp Asn Phe Glu 
        275                 280                 285             


Ala Leu Thr Gln Ala Glu Ala Trp Pro Ser Val Pro Thr Asp Leu Leu 
    290                 295                 300                 


Gln Leu Leu Leu Pro Arg Ser Asp Leu Ala Val Pro Ser Glu Leu Ala 
305                 310                 315                 320 


Leu Leu Lys Ala Val Asp Thr Trp Ser Trp Gly Glu Arg Ala Ser His 
                325                 330                 335     


Glu Glu Val Glu Gly Leu Val Glu Lys Ile Arg Phe Pro Met Met Leu 
            340                 345                 350         


Pro Glu Glu Leu Phe Glu Leu Gln Phe Asn Leu Ser Leu Tyr Trp Ser 
        355                 360                 365             


His Glu Ala Leu Phe Gln Lys Lys Thr Leu Gln Ala Leu Glu Phe His 
    370                 375                 380                 


Thr Val Pro Phe Gln Leu Leu Ala Arg Tyr Lys Gly Leu Asn Leu Thr 
385                 390                 395                 400 


Glu Asp Thr Tyr Lys Pro Arg Ile Tyr Thr Ser Pro Thr Trp Ser Ala 
                405                 410                 415     


Phe Val Thr Asp Ser Ser Trp Ser Ala Arg Lys Ser Gln Leu Val Tyr 
            420                 425                 430         


Gln Ser Arg Arg Gly Pro Leu Val Lys Tyr Ser Ser Asp Tyr Phe Gln 
        435                 440                 445             


Ala Pro Ser Asp Tyr Arg Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro 
    450                 455                 460                 


Gln His Pro Ser Phe Leu Phe Gln Asp Lys Arg Val Ser Trp Ser Leu 
465                 470                 475                 480 


Val Tyr Leu Pro Thr Ile Gln Ser Cys Trp Asn Tyr Gly Phe Ser Cys 
                485                 490                 495     


Ser Ser Asp Glu Leu Pro Val Leu Gly Leu Thr Lys Ser Gly Gly Ser 
            500                 505                 510         


Asp Arg Thr Ile Ala Tyr Glu Asn Lys Ala Leu Met Leu Cys Glu Gly 
        515                 520                 525             


Leu Phe Val Ala Asp Val Thr Asp Phe Glu Gly Trp Lys Ala Ala Ile 
    530                 535                 540                 


Pro Ser Ala Leu Asp Thr Asn Ser Ser Lys Ser Thr Ser Ser Phe Pro 
545                 550                 555                 560 


Cys Pro Ala Gly His Phe Asn Gly Phe Arg Thr Val Ile Arg Pro Phe 
                565                 570                 575     


Tyr Leu Thr Asn Ser Ser Gly Val Asp 
            580                 585 


<210>  237
<211>  3649
<212>  DNA
<213>  Homo sapiens

<400>  237
cccgctgtag ccgcgtgtgg gaggacgcac gggcctgctt caaagctttg ggataacagc     60

gcctccgggg gataatgaat gcggagcctc cgttttcagt cgacttcaga tgtgtctcca    120

cttttttccg ctgtagccgc aaggcaagga aacatttctc ttcccgtact gaggaggctg    180

aggagtgcac tgggtgttct tttctcctct aacccagaac tgcgagacag aggctgagtc    240

cctgtaaaga acagctccag aaaagccagg agagcgcagg agggcatccg ggaggccagg    300

aggggttcgc tggggcctca accgcaccca catcggtccc acctgcgagg gggcgggacc    360

tcgtggcgct ggaccaatca gcacccacct gcgctcacct ggcctcctcc cgctggctcc    420

cgggggctgc ggtgctcaaa ggggcaagag ctgagcggaa caccggcccg ccgtcgcggc    480

agctgcttca cccctctctc tgcagccatg gggctccctc gtggacctct cgcgtctctc    540

ctccttctcc aggtttgctg gctgcagtgc gcggcctccg agccgtgccg ggcggtcttc    600

agggaggctg aagtgacctt ggaggcggga ggcgcggagc aggagcccgg ccaggcgctg    660

gggaaagtat tcatgggctg ccctgggcaa gagccagctc tgtttagcac tgataatgat    720

gacttcactg tgcggaatgg cgagacagtc caggaaagaa ggtcactgaa ggaaaggaat    780

ccattgaaga tcttcccatc caaacgtatc ttacgaagac acaagagaga ttgggtggtt    840

gctccaatat ctgtccctga aaatggcaag ggtcccttcc cccagagact gaatcagctc    900

aagtctaata aagatagaga caccaagatt ttctacagca tcacggggcc gggggcagac    960

agcccccctg agggtgtctt cgctgtagag aaggagacag gctggttgtt gttgaataag   1020

ccactggacc gggaggagat tgccaagtat gagctctttg gccacgctgt gtcagagaat   1080

ggtgcctcag tggaggaccc catgaacatc tccatcatcg tgaccgacca gaatgaccac   1140

aagcccaagt ttacccagga caccttccga gggagtgtct tagagggagt cctaccaggt   1200

acttctgtga tgcaggtgac agccacggat gaggatgatg ccatctacac ctacaatggg   1260

gtggttgctt actccatcca tagccaagaa ccaaaggacc cacacgacct catgttcacc   1320

attcaccgga gcacaggcac catcagcgtc atctccagtg gcctggaccg ggaaaaagtc   1380

cctgagtaca cactgaccat ccaggccaca gacatggatg gggacggctc caccaccacg   1440

gcagtggcag tagtggagat ccttgatgcc aatgacaatg ctcccatgtt tgacccccag   1500

aagtacgagg cccatgtgcc tgagaatgca gtgggccatg aggtgcagag gctgacggtc   1560

actgatctgg acgcccccaa ctcaccagcg tggcgtgcca cctaccttat catgggcggt   1620

gacgacgggg accattttac catcaccacc caccctgaga gcaaccaggg catcctgaca   1680

accaggaagg gtttggattt tgaggccaaa aaccagcaca ccctgtacgt tgaagtgacc   1740

aacgaggccc cttttgtgct gaagctccca acctccacag ccaccatagt ggtccacgtg   1800

gaggatgtga atgaggcacc tgtgtttgtc ccaccctcca aagtcgttga ggtccaggag   1860

ggcatcccca ctggggagcc tgtgtgtgtc tacactgcag aagaccctga caaggagaat   1920

caaaagatca gctaccgcat cctgagagac ccagcagggt ggctagccat ggacccagac   1980

agtgggcagg tcacagctgt gggcaccctc gaccgtgagg atgagcagtt tgtgaggaac   2040

aacatctatg aagtcatggt cttggccatg gacaatggaa gccctcccac cactggcacg   2100

ggaacccttc tgctaacact gattgatgtc aatgaccatg gcccagtccc tgagccccgt   2160

cagatcacca tctgcaacca aagccctgtg cgccaggtgc tgaacatcac ggacaaggac   2220

ctgtctcccc acacctcccc tttccaggcc cagctcacag atgactcaga catctactgg   2280

acggcagagg tcaacgagga aggtgacaca gtggtcttgt ccctgaagaa gttcctgaag   2340

caggatacat atgacgtgca cctttctctg tctgaccatg gcaacaaaga gcagctgacg   2400

gtgatcaggg ccactgtgtg cgactgccat ggccatgtcg aaacctgccc tggaccctgg   2460

aagggaggtt tcatcctccc tgtgctgggg gctgtcctgg ctctgctgtt cctcctgctg   2520

gtgctgcttt tgttggtgag aaagaagcgg aagatcaagg agcccctcct actcccagaa   2580

gatgacaccc gtgacaacgt cttctactat ggcgaagagg ggggtggcga agaggaccag   2640

gactatgaca tcacccagct ccaccgaggt ctggaggcca ggccggaggt ggttctccgc   2700

aatgacgtgg caccaaccat catcccgaca cccatgtacc gtcctcggcc agccaaccca   2760

gatgaaatcg gcaactttat aattgagaac ctgaaggcgg ctaacacaga ccccacagcc   2820

ccgccctacg acaccctctt ggtgttcgac tatgagggca gcggctccga cgccgcgtcc   2880

ctgagctccc tcacctcctc cgcctccgac caagaccaag attacgatta tctgaacgag   2940

tggggcagcc gcttcaagaa gctggcagac atgtacggtg gcggggagga cgactaggcg   3000

gcctgcctgc agggctgggg accaaacgtc aggccacaga gcatctccaa ggggtctcag   3060

ttcccccttc agctgaggac ttcggagctt gtcaggaagt ggccgtagca acttggcgga   3120

gacaggctat gagtctgacg ttagagtggt ggcttcctta gcctttcagg atggaggaat   3180

gtgggcagtt tgacttcagc actgaaaacc tctccacctg ggccagggtt gcctcagagg   3240

ccaagtttcc agaagcctct tacctgccgt aaaatgctca accctgtgtc ctgggcctgg   3300

gcctgctgtg actgacctac agtggacttt ctctctggaa tggaaccttc ttaggcctcc   3360

tggtgcaact taattttttt ttttaatgct atcttcaaaa cgttagagaa agttcttcaa   3420

aagtgcagcc cagagctgct gggcccactg gccgtcctgc atttctggtt tccagacccc   3480

aatgcctccc attcggatgg atctctgcgt ttttatactg agtgtgccta ggttgcccct   3540

tattttttat tttccctgtt gcgttgctat agatgaaggg tgaggacaat cgtgtatatg   3600

tactagaact tttttattaa agaaactttt cccagaaaaa aaaaaaaaa               3649


<210>  238
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Gly Leu Pro Arg Gly Pro Leu Ala Ser Leu Leu Leu Leu Gln Val 
1               5                   10                  15      


Cys Trp Leu Gln Cys Ala Ala Ser Glu Pro Cys Arg Ala Val Phe Arg 
            20                  25                  30          


Glu Ala Glu Val Thr Leu Glu Ala Gly Gly Ala Glu Gln Glu Pro Gly 
        35                  40                  45              


Gln Ala Leu Gly Lys Val Phe Met Gly Cys Pro Gly Gln Glu Pro Ala 
    50                  55                  60                  


Leu Phe Ser Thr Asp Asn Asp Asp Phe Thr Val Arg Asn Gly Glu Thr 
65                  70                  75                  80  


Val Gln Glu Arg Arg Ser Leu Lys Glu Arg Asn Pro Leu Lys Ile Phe 
                85                  90                  95      


Pro Ser Lys Arg Ile Leu Arg Arg His Lys Arg Asp Trp Val Val Ala 
            100                 105                 110         


Pro Ile Ser Val Pro Glu Asn Gly Lys Gly Pro Phe Pro Gln Arg Leu 
        115                 120                 125             


Asn Gln Leu Lys Ser Asn Lys Asp Arg Asp Thr Lys Ile Phe Tyr Ser 
    130                 135                 140                 


Ile Thr Gly Pro Gly Ala Asp Ser Pro Pro Glu Gly Val Phe Ala Val 
145                 150                 155                 160 


Glu Lys Glu Thr Gly Trp Leu Leu Leu Asn Lys Pro Leu Asp Arg Glu 
                165                 170                 175     


Glu Ile Ala Lys Tyr Glu Leu Phe Gly His Ala Val Ser Glu Asn Gly 
            180                 185                 190         


Ala Ser Val Glu Asp Pro Met Asn Ile Ser Ile Ile Val Thr Asp Gln 
        195                 200                 205             


Asn Asp His Lys Pro Lys Phe Thr Gln Asp Thr Phe Arg Gly Ser Val 
    210                 215                 220                 


Leu Glu Gly Val Leu Pro Gly Thr Ser Val Met Gln Val Thr Ala Thr 
225                 230                 235                 240 


Asp Glu Asp Asp Ala Ile Tyr Thr Tyr Asn Gly Val Val Ala Tyr Ser 
                245                 250                 255     


Ile His Ser Gln Glu Pro Lys Asp Pro His Asp Leu Met Phe Thr Ile 
            260                 265                 270         


His Arg Ser Thr Gly Thr Ile Ser Val Ile Ser Ser Gly Leu Asp Arg 
        275                 280                 285             


Glu Lys Val Pro Glu Tyr Thr Leu Thr Ile Gln Ala Thr Asp Met Asp 
    290                 295                 300                 


Gly Asp Gly Ser Thr Thr Thr Ala Val Ala Val Val Glu Ile Leu Asp 
305                 310                 315                 320 


Ala Asn Asp Asn Ala Pro Met Phe Asp Pro Gln Lys Tyr Glu Ala His 
                325                 330                 335     


Val Pro Glu Asn Ala Val Gly His Glu Val Gln Arg Leu Thr Val Thr 
            340                 345                 350         


Asp Leu Asp Ala Pro Asn Ser Pro Ala Trp Arg Ala Thr Tyr Leu Ile 
        355                 360                 365             


Met Gly Gly Asp Asp Gly Asp His Phe Thr Ile Thr Thr His Pro Glu 
    370                 375                 380                 


Ser Asn Gln Gly Ile Leu Thr Thr Arg Lys Gly Leu Asp Phe Glu Ala 
385                 390                 395                 400 


Lys Asn Gln His Thr Leu Tyr Val Glu Val Thr Asn Glu Ala Pro Phe 
                405                 410                 415     


Val Leu Lys Leu Pro Thr Ser Thr Ala Thr Ile Val Val His Val Glu 
            420                 425                 430         


Asp Val Asn Glu Ala Pro Val Phe Val Pro Pro Ser Lys Val Val Glu 
        435                 440                 445             


Val Gln Glu Gly Ile Pro Thr Gly Glu Pro Val Cys Val Tyr Thr Ala 
    450                 455                 460                 


Glu Asp Pro Asp Lys Glu Asn Gln Lys Ile Ser Tyr Arg Ile Leu Arg 
465                 470                 475                 480 


Asp Pro Ala Gly Trp Leu Ala Met Asp Pro Asp Ser Gly Gln Val Thr 
                485                 490                 495     


Ala Val Gly Thr Leu Asp Arg Glu Asp Glu Gln Phe Val Arg Asn Asn 
            500                 505                 510         


Ile Tyr Glu Val Met Val Leu Ala Met Asp Asn Gly Ser Pro Pro Thr 
        515                 520                 525             


Thr Gly Thr Gly Thr Leu Leu Leu Thr Leu Ile Asp Val Asn Asp His 
    530                 535                 540                 


Gly Pro Val Pro Glu Pro Arg Gln Ile Thr Ile Cys Asn Gln Ser Pro 
545                 550                 555                 560 


Val Arg Gln Val Leu Asn Ile Thr Asp Lys Asp Leu Ser Pro His Thr 
                565                 570                 575     


Ser Pro Phe Gln Ala Gln Leu Thr Asp Asp Ser Asp Ile Tyr Trp Thr 
            580                 585                 590         


Ala Glu Val Asn Glu Glu Gly Asp Thr Val Val Leu Ser Leu Lys Lys 
        595                 600                 605             


Phe Leu Lys Gln Asp Thr Tyr Asp Val His Leu Ser Leu Ser Asp His 
    610                 615                 620                 


Gly Asn Lys Glu Gln Leu Thr Val Ile Arg Ala Thr Val Cys Asp Cys 
625                 630                 635                 640 


His Gly His Val Glu Thr Cys Pro Gly Pro Trp Lys Gly Gly Phe Ile 
                645                 650                 655     


Leu Pro Val Leu Gly Ala Val Leu Ala Leu Leu Phe Leu Leu Leu Val 
            660                 665                 670         


Leu Leu Leu Leu Val Arg Lys Lys Arg Lys Ile Lys Glu Pro Leu Leu 
        675                 680                 685             


Leu Pro Glu Asp Asp Thr Arg Asp Asn Val Phe Tyr Tyr Gly Glu Glu 
    690                 695                 700                 


Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Ile Thr Gln Leu His Arg 
705                 710                 715                 720 


Gly Leu Glu Ala Arg Pro Glu Val Val Leu Arg Asn Asp Val Ala Pro 
                725                 730                 735     


Thr Ile Ile Pro Thr Pro Met Tyr Arg Pro Arg Pro Ala Asn Pro Asp 
            740                 745                 750         


Glu Ile Gly Asn Phe Ile Ile Glu Asn Leu Lys Ala Ala Asn Thr Asp 
        755                 760                 765             


Pro Thr Ala Pro Pro Tyr Asp Thr Leu Leu Val Phe Asp Tyr Glu Gly 
    770                 775                 780                 


Ser Gly Ser Asp Ala Ala Ser Leu Ser Ser Leu Thr Ser Ser Ala Ser 
785                 790                 795                 800 


Asp Gln Asp Gln Asp Tyr Asp Tyr Leu Asn Glu Trp Gly Ser Arg Phe 
                805                 810                 815     


Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu Asp Asp 
            820                 825                 


<210>  239
<211>  1709
<212>  DNA
<213>  Homo sapiens

<400>  239
ggtacctcct gccagcatct cttgggtttg ctgagaactc acgggctcca gctacctggc     60

catgaccacc acatttctgc aaacttcttc ctccaccttt gggggtggct caacccgagg    120

gggttccctc ctggctgggg gaggtggctt tggtgggggg agtctctctg ggggaggtgg    180

aagccgaagt atctcagctt cttctgctag gtttgtctct tcagggtcag gaggaggata    240

tgggggtggc atgagggtct gtggctttgg tggaggggct ggtagtgttt tcggtggagg    300

ctttggaggg ggcgttggtg ggggttttgg tggtggcttt ggtggtggcg atggtggtct    360

cctctctggc aatgagaaaa ttaccatgca gaacctcaat gaccgcctgg cctcctacct    420

ggacaaggta cgtgccctgg aggaggccaa tgctgacctg gaggtgaaga tccatgactg    480

gtaccagaag cagaccccaa ccagcccaga atgcgactac agccaatact tcaagaccat    540

tgaagagctc cgggacaaga tcatggccac caccatcgac aactcccggg tcatcctgga    600

gatcgacaat gccaggctgg ctgcggacga cttcaggctc aagtatgaga atgagctggc    660

cctgcgccag ggcgttgagg ctgacatcaa cggcttgcgc cgagtcctgg atgagctgac    720

cctggccagg actgacctgg agatgcagat cgagggcctg aatgaggagc tagcctacct    780

gaagaagaac cacgaagagg agatgaagga gttcagcagc cagctggccg gccaggtcaa    840

tgtggagatg gacgcagcac cgggtgtgga cctgacccgt gtgctggcag agatgaggga    900

gcagtacgag gccatggcgg agaagaaccg ccgggatgtc gaggcctggt tcttcagcaa    960

gactgaggag ctgaacaaag aggtggcctc caacacagaa atgatccaga ccagcaagac   1020

ggagatcaca gacctgagac gcacgatgca ggagctggag atcgagctgc agtcccagct   1080

cagcatgaaa gctgggctgg agaactcact ggccgagaca gagtgccgct atgccacgca   1140

gctgcagcag atccaggggc tcattggtgg cctggaggcc cagctgagtg agctccgatg   1200

cgagatggag gctcagaacc aggagtacaa gatgctgctt gacataaaga cacggctgga   1260

gcaggagatc gctacttacc gcagcctgct cgagggccag gatgccaaga tggctggcat   1320

tggcatcagg gaagcctctt caggaggtgg tggtagcagc agcaatttcc acatcaatgt   1380

agaagagtca gtggatggac aggtggtttc ttcccacaag agagaaatct aagtgtctat   1440

tgcaggagaa acgtcccttg ccactcccca ctctcatcag gccaagtgga ggactggcca   1500

gagggcctgc acatgcaaac tccagtccct gccttcagag agctgaaaag ggtccctcgg   1560

tcttttattt cagggctttg catgcgctct attccccctc tgcctctccc caccttcttt   1620

ggagcaagga gatgcagctg tattgtgtaa caagctcatt tgtacagtgt ctgttcatgt   1680

aataaagaat tacttttcct tttgcaaat                                     1709


<210>  240
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Thr Thr Thr Phe Leu Gln Thr Ser Ser Ser Thr Phe Gly Gly Gly 
1               5                   10                  15      


Ser Thr Arg Gly Gly Ser Leu Leu Ala Gly Gly Gly Gly Phe Gly Gly 
            20                  25                  30          


Gly Ser Leu Ser Gly Gly Gly Gly Ser Arg Ser Ile Ser Ala Ser Ser 
        35                  40                  45              


Ala Arg Phe Val Ser Ser Gly Ser Gly Gly Gly Tyr Gly Gly Gly Met 
    50                  55                  60                  


Arg Val Cys Gly Phe Gly Gly Gly Ala Gly Ser Val Phe Gly Gly Gly 
65                  70                  75                  80  


Phe Gly Gly Gly Val Gly Gly Gly Phe Gly Gly Gly Phe Gly Gly Gly 
                85                  90                  95      


Asp Gly Gly Leu Leu Ser Gly Asn Glu Lys Ile Thr Met Gln Asn Leu 
            100                 105                 110         


Asn Asp Arg Leu Ala Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu 
        115                 120                 125             


Ala Asn Ala Asp Leu Glu Val Lys Ile His Asp Trp Tyr Gln Lys Gln 
    130                 135                 140                 


Thr Pro Thr Ser Pro Glu Cys Asp Tyr Ser Gln Tyr Phe Lys Thr Ile 
145                 150                 155                 160 


Glu Glu Leu Arg Asp Lys Ile Met Ala Thr Thr Ile Asp Asn Ser Arg 
                165                 170                 175     


Val Ile Leu Glu Ile Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg 
            180                 185                 190         


Leu Lys Tyr Glu Asn Glu Leu Ala Leu Arg Gln Gly Val Glu Ala Asp 
        195                 200                 205             


Ile Asn Gly Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Ala Arg Thr 
    210                 215                 220                 


Asp Leu Glu Met Gln Ile Glu Gly Leu Asn Glu Glu Leu Ala Tyr Leu 
225                 230                 235                 240 


Lys Lys Asn His Glu Glu Glu Met Lys Glu Phe Ser Ser Gln Leu Ala 
                245                 250                 255     


Gly Gln Val Asn Val Glu Met Asp Ala Ala Pro Gly Val Asp Leu Thr 
            260                 265                 270         


Arg Val Leu Ala Glu Met Arg Glu Gln Tyr Glu Ala Met Ala Glu Lys 
        275                 280                 285             


Asn Arg Arg Asp Val Glu Ala Trp Phe Phe Ser Lys Thr Glu Glu Leu 
    290                 295                 300                 


Asn Lys Glu Val Ala Ser Asn Thr Glu Met Ile Gln Thr Ser Lys Thr 
305                 310                 315                 320 


Glu Ile Thr Asp Leu Arg Arg Thr Met Gln Glu Leu Glu Ile Glu Leu 
                325                 330                 335     


Gln Ser Gln Leu Ser Met Lys Ala Gly Leu Glu Asn Ser Leu Ala Glu 
            340                 345                 350         


Thr Glu Cys Arg Tyr Ala Thr Gln Leu Gln Gln Ile Gln Gly Leu Ile 
        355                 360                 365             


Gly Gly Leu Glu Ala Gln Leu Ser Glu Leu Arg Cys Glu Met Glu Ala 
    370                 375                 380                 


Gln Asn Gln Glu Tyr Lys Met Leu Leu Asp Ile Lys Thr Arg Leu Glu 
385                 390                 395                 400 


Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu Glu Gly Gln Asp Ala Lys 
                405                 410                 415     


Met Ala Gly Ile Gly Ile Arg Glu Ala Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Ser Ser Asn Phe His Ile Asn Val Glu Glu Ser Val Asp Gly Gln Val 
        435                 440                 445             


Val Ser Ser His Lys Arg Glu Ile 
    450                 455     


<210>  241
<211>  8097
<212>  DNA
<213>  Homo sapiens

<400>  241
atttcctata aatatcacaa atatttccaa caaaagagca tagatgtctt ttatacaatt     60

cttttgagaa tgattctgca gatttctgca ttttctcctc attaatttga cctgggatgg    120

ttttcactga ggaaaaaaat ctttaagcaa acatgttaaa tgtttaccta tataaaaatt    180

attacttcag gtgactccga taatataacg catgtgtgga atgaggatga tggacagacc    240

ttatctccaa gcagtctggc tgcacagctc ctaattctgg aaaactttga agatgccctc    300

ttaaatatat cagcaaatag tccttatatt ccttacttgg catgtgtgag aaatgtgact    360

gacagtttgg ccagaggttc accagaaaat ctaagactcc tgcagtccac aatacgattt    420

aaaaaatctt ttcttcgcaa tggttcctat gaagattact ttcctccagt tcctgaagtc    480

ctaaaatcaa aactgtctca acttcgaaac ttgaccgaac ttctttgtga atctgaaact    540

ttcagtttga tagagaagtc atgccagctc tctgatatga gctttgggag cctgtgtgaa    600

gaaagtgagt ttgatctgca actcctcgaa gcggcagagc tgggcaccga aatagcagcc    660

agcttactgt accatgacaa tgtcatatct aaaaaagtga gagatttgct gactggagat    720

ccaagcaaaa ttaatttaaa tatggatcag tttctagaac aggcactgca aatgaattac    780

ttggaaaata tcactcagtt aataccgatc atagaagcca tgctgcatgt caataacagt    840

gcagatgctt ctgaaaagcc aggtcagtta ctagaaatgt ttaaaaatgt tgaagagctg    900

aaagaagatt taaggagaac aacaggaatg tccaacagga ctattgacaa gttgctggcc    960

attcccatcc ctgataatag agctgagatt atttctcagg tgttctggct gcattcctgt   1020

gatactaata tcaccactcc caaactagaa gatgcaatga aagaattctg caacctgtct   1080

ctttcagaga gatcccggca gtcttacctc atcggactca cccttctgca ctacttaaac   1140

atttacaact tcacatacaa ggtgtttttc ccgaggaaag atcaaaagcc agtagaaaag   1200

atgatggagc tcttcataag actaaaagag attctcaatc agatggcttc tggcacacat   1260

ccgctgctag acaaaatgag atccctgaag caaatgcatc tgcccagaag tgttccatta   1320

acacaggcaa tgtacagaag caaccgaatg aacacaccac aaggatcatt tagcaccatc   1380

tcccaagcat tatgttctca aggaattacc actgaatatt taactgccat gctgccctct   1440

tcccagaggc caaaaggcaa ccacaccaag gattttttga cttataaatt aactaaagag   1500

caaattgctt caaaatatgg aattcccata aattccacac cattttgctt ctccctttat   1560

aaagacatca ttaacatgcc cgctggacct gtgatttggg ctttcttgaa acctatgttg   1620

ttgggaagaa ttttgtatgc accatataac ccagtcacaa aggcaataat ggaaaagtcc   1680

aatgtaactc tgagacagct ggcggaatta agagaaaaat ctcaagagtg gatggataag   1740

tcgccacttt tcatgaattc cttccatctg ttaaaccagg caattccaat gctccagaat   1800

actctaagga acccttttgt gcaagttttt gtaaagttct ccgtgggact cgatgctgtt   1860

gaactattga aacagataga tgaactcgat attctaagac tgaaattaga gaacaacatt   1920

gacatcatcg atcagcttaa cacactatct tccctgacag taaatatttc ctcttgtgta   1980

ttatatgacc gtattcaggc agcaaaaacc atagatgaaa tggagagaga ggctaaaagg   2040

ctctacaaaa gcaacgaact ctttggaagt gttattttta agcttccttc taacagaagc   2100

tggcacagag gctatgactc tggaaatgtc tttcttcctc ctgtcataaa atataccatc   2160

cggatgagtc tcaagaccgc acagaccaca agaagcctaa gaaccaagat ttgggctcca   2220

gggccacaca attctccatc acacaaccag atctatggca gggcttttat ttatttacag   2280

gatagtattg aaagagcaat cattgaattg caaactggaa ggaactccca ggaaatagca   2340

gtccaggttc aagcaattcc ttatccctgc ttcatgaaag acaacttcct aaccagtgtc   2400

tcttattctc ttccaattgt gcttatggtt gcctgggttg tatttatagc tgcctttgta   2460

aaaaagcttg tctatgagaa agacctccgg cttcatgagt acatgaagat gatgggtgtg   2520

aactcctgca gccatttctt tgcctggctt atagagagtg ttggattttt actggttacc   2580

atcgtgatcc tcatcattat actcaagttt ggcaatattc ttcctaaaac aaatgggttc   2640

attttgttcc tgtatttttc ggactacagc ttctcggtta ttgccatgag ctatcttatc   2700

agtgtcttct tcaacaacac caacattgca gctctgatcg gaagcctcat ctacatcatt   2760

gccttctttc catttattgt tctggttaca gtggagaatg agttgagcta tgtattgaaa   2820

gtgttcatga gcctgctgtc cccaacagca ttcagctatg caagccaata cattgcacga   2880

tacgaagaac agggcattgg tcttcagtgg gaaaatatgt acacctcccc ggttcaggat   2940

gacaccacct catttggctg gctgtgctgt ctaatcctag ctgactcttt catttatttc   3000

cttattgctt ggtatgtcag gaatgtcttc ccagggacat acggtatggc agctccctgg   3060

tattttccaa ttcttccttc ctattggaag gagcgatttg ggtgtgcaga ggtgaagcct   3120

gagaagagca atggcctcat gtttactaac atcatgatgc agaacaccaa cccatctgcc   3180

agtcctgaat acatgttttc ctctaacatc gagcctgaac ctaaagatct cacagtcggg   3240

gttgccctgc atggggtcac aaagatctat ggctcaaaag ttgctgttga taacctcaat   3300

ctgaactttt atgaagggca tattacttca ttgctggggc ccaatggagc tgggaaaact   3360

actaccattt ccatgttaac tgggctgttt ggggcctcag caggcaccat ttttgtatat   3420

ggaaaagata tcaaaacaga cctacacacg gtacggaaga acatgggagt ctgtatgcag   3480

cacgacgtct tgttcagtta cctcactact aaggagcacc ttctcctata tggttccatc   3540

aaagttcctc actggactaa aaagcagctc cacgaggaag taaaaaggac tttaaaagat   3600

actggactat atagccatcg tcataagaga gttggaacac tgtcaggagg catgaagagg   3660

aagttatcta tatccatagc tctcattggt ggatcaaggg tagtaatttt ggatgaacca   3720

tctactggag ttgacccatg ttctcgccga agtatatggg atgttatatc caagaacaaa   3780

actgccagaa caatcattct gtcaacgcac cacttggacg aggctgaagt gctgagtgac   3840

cgcatcgcct tcctggagca gggtgggctt aggtgctgtg ggtccccatt ttacctcaag   3900

gaagcctttg gcgatgggta tcacctcacg cttaccaaga agaagagtcc aaatttaaat   3960

gcaaatgcag tatgtgacac catggccgtg acagcaatga tccaatcaca tctccccgaa   4020

gcctacctca aggaggatat tgggggagag cttgtttatg tacttcctcc attcagcacc   4080

aaagtctcag gggcctacct gtcactccta cgggcactcg acaatggcat gggtgacctc   4140

aacatcgggt gctacggcat ttcagatacc accgtggagg aggtctttct gaacttgacc   4200

aaagagtcac aaaaaaatag tgctatgagt cttgagcact taacacaaaa gaaaattggg   4260

aattccaatg ccaatggcat ctcaactcct gacgatttat ctgtgagcag cagcaatttc   4320

acagacagag atgacaaaat cctgacaaga ggagagaggc tggatggctt tggactgttg   4380

ctgaagaaga tcatggctat actcatcaag aggttccacc acacccgcag gaactggaaa   4440

ggtctcattg ctcaggttat cctccccatc gtctttgtta ccactgccat gggccttggc   4500

acactgagaa attccagcaa cagttatcca gagattcaga tctccccctc tctttatggt   4560

acctccgaac agacagcctt ctatgctaat tatcacccga gcacggaagc acttgtctca   4620

gcaatgtggg acttccctgg aattgacaac atgtgtctga acaccagtga tctacagtgt   4680

ttaaacaaag acagtctgga aaaatggaac accagtggag aacccatcac taattttggt   4740

gtttgctcct gctcagaaaa tgtccaggaa tgtcctaaat ttaactattc cccaccgcac   4800

agaagaactt actcatccca ggtaatttat aacctcactg ggcaacgagt ggaaaattat   4860

cttatatcaa ctgcaaatga gtttgtccaa aaaagatatg gaggttggag ttttgggctg   4920

cctttgacaa aagaccttcg ttttgatata acaggagtcc ctgccaatag aacacttgcc   4980

aaggtatggt atgatccaga aggctatcac tcccttccag cttacctcaa cagcctgaat   5040

aatttccttc tgcgagttaa catgtcaaaa tacgatgctg cccgacatgg catcatcatg   5100

tatagccatc cttatccagg agtgcaagac caagaacaag ccacaatcag cagtttaatc   5160

gatattttag tggcactgtc tatcttgatg ggctactctg tcaccaccgc cagctttgtc   5220

acctatgttg taagggaaca tcaaaccaaa gccaaacagt tgcagcacat ttcaggcatt   5280

ggcgtgacat gctactgggt aacaaacttc atttatgaca tggttttcta cttggtgcct   5340

gtagcgtttt caattggtat cattgcgatt ttcaaattac ctgcattcta cagtgaaaac   5400

aacctaggcg ctgtatctct cctacttctc ctgtttgggt atgcaacatt ttcctggatg   5460

tacttgctgg ctgggctctt ccatgaaaca ggaatggcct tcatcactta cgtctgtgtc   5520

aacttgtttt ttggcattaa ttccattgtt tccctgtcag tggtatactt tctttccaag   5580

gaaaagccta atgatccgac tttagaactt atttctgaaa ccctcaagcg cattttcctg   5640

attttcccac aattctgttt tggctacggt ttgattgaac tttctcaaca acagtcggtc   5700

ctagacttct taaaagcata tggagtggaa tacccaaatg aaacctttga gatgaataaa   5760

ctaggtgcaa tgtttgtggc tttggtttct cagggcacca tgtttttttc cttgcgactc   5820

ttaatcaacg aatccctgat aaagaaactc aggcttttct tcagaaaatt taattcttca   5880

catgtaaggg agacaataga tgaggatgaa gatgtgcggg ctgagagatt aagagttgag   5940

agtggtgcag ctgaatttga cttggtccaa ctttattgtc tcacaaagac ctaccaactt   6000

atccacaaaa agattatagc tgtaaacaac atcagcattg ggatacctgc tggagagtgt   6060

tttgggcttc ttggagtgaa tggagcagga aagaccacta tattcaagat gctgacagga   6120

gacatcattc cttcaagtgg aaacattctg atcagaaata agaccggatc tctgggtcac   6180

gttgattctc acagctcatt agttggctac tgtcctcagg aagatgcctt agatgacctg   6240

gtaactgtgg aagaacattt gtatttctat gccagggtac atggaattcc agaaaaggat   6300

attaaagaaa ctgttcataa actccttagg agacttcacc tgatgccctt caaggacaga   6360

gctacctcta tgtgcagtta tggcacaaaa agaaaattat ccactgcact ggccttgata   6420

gggaaacctt ccattctact gctggatgag ccgagctctg gcatggatcc gaagtcgaaa   6480

cggcacctct ggaagatcat ttcagaagaa gtacagaaca aatgttccgt catcctcaca   6540

tctcacagca tggaagaatg tgaagctctc tgtaccaggt tggccattat ggtgaatgga   6600

aagtttcaat gtattggatc tttgcagcac ataaagagca ggtttggacg aggatttact   6660

gtcaaagttc acttgaagaa taacaaagtg accatggaga ccctcacaaa gttcatgcag   6720

ctgcactttc caaaaacata cttaaaagat cagcacctca gcatgctaga gtatcatgta   6780

ccagtcacag caggaggagt cgcaaacatt tttgatctgc tggaaaccaa caagactgct   6840

ttaaatatta caaatttctt agtgagtcag accactctgg aagaggtttt catcaacttt   6900

gccaaagacc agaagtccta tgaaactgct gataccagca gccaaggttc cactataagt   6960

gttgactcac aagatgacca gatggagtct taacacttcc agcaaactca atctcagcgt   7020

gtgaccaatg gcttcatttt gaagaaaagc cacagaagat acacttccgc aagatatctt   7080

cattttaaag taaagtaata tactgtatgg aaagttacaa ctgtgttaga ctaacaagta   7140

attataaaag gaaatttttc cttctaaggt cagtgagtgt tgttgctact gaaatgaatt   7200

cctgtatact caacactgtg agcatgctaa tgtatatgct ggtgattctt atgcaaaggt   7260

gaagccacct caagatgaat atcttaattt attactttca ataaaaagac agtttaaaag   7320

gcatggattt tggtagttga aatataagag tggagaagaa aagtcagatg gtttgtggca   7380

ggtgccaccg ggcaagcaga caacataatt tatttccaga aaacaacaga atgaacatca   7440

tcatgaatac atgaatcggc tgtgatgtgt gaactgctaa gggccaaatg aacgtttgca   7500

gagcagtggg cacaatgttt acaatgtatg tgtatgtcac tttcggtacc tgtgaatgca   7560

tggggacgtg ctgaacccga aaaaaagtgc ctttccataa ggactgcaat agagagggca   7620

atttaccctg gtggtacacg gaacctagat tcactcctgc catgccttgc caatagtaag   7680

ctgcagggtg gaacaagaaa tcacttgctc tggggggaag ggagggggga atgggtgtgt   7740

cagctgggta gatacaaacc ctgaaaagag aatccatgtg ctactggcag gcaacatttt   7800

ttaaagctct ttcagaaacc ctcatatttg gggtttcttt tcaggaaaca ttcctgtgga   7860

gggaaaacga atatgaagat aattttcagc taattatctg ggtgacccag aatcgtgtat   7920

atggctatag gatagacttc ttaataatgg caagtgacgt ggccctgggg aaaggtgctt   7980

tatgtaccgt gtgtgcgtgt atgtgtgtgt atctatacaa gtttgtcagc tttggcatga   8040

ctgtttgtct cgaaaaccaa taaactcaaa gtttagaaaa actcaaaaaa aaaaaaa      8097


<210>  242
<211>  2277
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Phe Thr Tyr Ile Lys Ile Ile Thr Ser Gly Asp Ser Asp Asn Ile 
1               5                   10                  15      


Thr His Val Trp Asn Glu Asp Asp Gly Gln Thr Leu Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Ala Gln Leu Leu Ile Leu Glu Asn Phe Glu Asp Ala Leu Leu 
        35                  40                  45              


Asn Ile Ser Ala Asn Ser Pro Tyr Ile Pro Tyr Leu Ala Cys Val Arg 
    50                  55                  60                  


Asn Val Thr Asp Ser Leu Ala Arg Gly Ser Pro Glu Asn Leu Arg Leu 
65                  70                  75                  80  


Leu Gln Ser Thr Ile Arg Phe Lys Lys Ser Phe Leu Arg Asn Gly Ser 
                85                  90                  95      


Tyr Glu Asp Tyr Phe Pro Pro Val Pro Glu Val Leu Lys Ser Lys Leu 
            100                 105                 110         


Ser Gln Leu Arg Asn Leu Thr Glu Leu Leu Cys Glu Ser Glu Thr Phe 
        115                 120                 125             


Ser Leu Ile Glu Lys Ser Cys Gln Leu Ser Asp Met Ser Phe Gly Ser 
    130                 135                 140                 


Leu Cys Glu Glu Ser Glu Phe Asp Leu Gln Leu Leu Glu Ala Ala Glu 
145                 150                 155                 160 


Leu Gly Thr Glu Ile Ala Ala Ser Leu Leu Tyr His Asp Asn Val Ile 
                165                 170                 175     


Ser Lys Lys Val Arg Asp Leu Leu Thr Gly Asp Pro Ser Lys Ile Asn 
            180                 185                 190         


Leu Asn Met Asp Gln Phe Leu Glu Gln Ala Leu Gln Met Asn Tyr Leu 
        195                 200                 205             


Glu Asn Ile Thr Gln Leu Ile Pro Ile Ile Glu Ala Met Leu His Val 
    210                 215                 220                 


Asn Asn Ser Ala Asp Ala Ser Glu Lys Pro Gly Gln Leu Leu Glu Met 
225                 230                 235                 240 


Phe Lys Asn Val Glu Glu Leu Lys Glu Asp Leu Arg Arg Thr Thr Gly 
                245                 250                 255     


Met Ser Asn Arg Thr Ile Asp Lys Leu Leu Ala Ile Pro Ile Pro Asp 
            260                 265                 270         


Asn Arg Ala Glu Ile Ile Ser Gln Val Phe Trp Leu His Ser Cys Asp 
        275                 280                 285             


Thr Asn Ile Thr Thr Pro Lys Leu Glu Asp Ala Met Lys Glu Phe Cys 
    290                 295                 300                 


Asn Leu Ser Leu Ser Glu Arg Ser Arg Gln Ser Tyr Leu Ile Gly Leu 
305                 310                 315                 320 


Thr Leu Leu His Tyr Leu Asn Ile Tyr Asn Phe Thr Tyr Lys Val Phe 
                325                 330                 335     


Phe Pro Arg Lys Asp Gln Lys Pro Val Glu Lys Met Met Glu Leu Phe 
            340                 345                 350         


Ile Arg Leu Lys Glu Ile Leu Asn Gln Met Ala Ser Gly Thr His Pro 
        355                 360                 365             


Leu Leu Asp Lys Met Arg Ser Leu Lys Gln Met His Leu Pro Arg Ser 
    370                 375                 380                 


Val Pro Leu Thr Gln Ala Met Tyr Arg Ser Asn Arg Met Asn Thr Pro 
385                 390                 395                 400 


Gln Gly Ser Phe Ser Thr Ile Ser Gln Ala Leu Cys Ser Gln Gly Ile 
                405                 410                 415     


Thr Thr Glu Tyr Leu Thr Ala Met Leu Pro Ser Ser Gln Arg Pro Lys 
            420                 425                 430         


Gly Asn His Thr Lys Asp Phe Leu Thr Tyr Lys Leu Thr Lys Glu Gln 
        435                 440                 445             


Ile Ala Ser Lys Tyr Gly Ile Pro Ile Asn Ser Thr Pro Phe Cys Phe 
    450                 455                 460                 


Ser Leu Tyr Lys Asp Ile Ile Asn Met Pro Ala Gly Pro Val Ile Trp 
465                 470                 475                 480 


Ala Phe Leu Lys Pro Met Leu Leu Gly Arg Ile Leu Tyr Ala Pro Tyr 
                485                 490                 495     


Asn Pro Val Thr Lys Ala Ile Met Glu Lys Ser Asn Val Thr Leu Arg 
            500                 505                 510         


Gln Leu Ala Glu Leu Arg Glu Lys Ser Gln Glu Trp Met Asp Lys Ser 
        515                 520                 525             


Pro Leu Phe Met Asn Ser Phe His Leu Leu Asn Gln Ala Ile Pro Met 
    530                 535                 540                 


Leu Gln Asn Thr Leu Arg Asn Pro Phe Val Gln Val Phe Val Lys Phe 
545                 550                 555                 560 


Ser Val Gly Leu Asp Ala Val Glu Leu Leu Lys Gln Ile Asp Glu Leu 
                565                 570                 575     


Asp Ile Leu Arg Leu Lys Leu Glu Asn Asn Ile Asp Ile Ile Asp Gln 
            580                 585                 590         


Leu Asn Thr Leu Ser Ser Leu Thr Val Asn Ile Ser Ser Cys Val Leu 
        595                 600                 605             


Tyr Asp Arg Ile Gln Ala Ala Lys Thr Ile Asp Glu Met Glu Arg Glu 
    610                 615                 620                 


Ala Lys Arg Leu Tyr Lys Ser Asn Glu Leu Phe Gly Ser Val Ile Phe 
625                 630                 635                 640 


Lys Leu Pro Ser Asn Arg Ser Trp His Arg Gly Tyr Asp Ser Gly Asn 
                645                 650                 655     


Val Phe Leu Pro Pro Val Ile Lys Tyr Thr Ile Arg Met Ser Leu Lys 
            660                 665                 670         


Thr Ala Gln Thr Thr Arg Ser Leu Arg Thr Lys Ile Trp Ala Pro Gly 
        675                 680                 685             


Pro His Asn Ser Pro Ser His Asn Gln Ile Tyr Gly Arg Ala Phe Ile 
    690                 695                 700                 


Tyr Leu Gln Asp Ser Ile Glu Arg Ala Ile Ile Glu Leu Gln Thr Gly 
705                 710                 715                 720 


Arg Asn Ser Gln Glu Ile Ala Val Gln Val Gln Ala Ile Pro Tyr Pro 
                725                 730                 735     


Cys Phe Met Lys Asp Asn Phe Leu Thr Ser Val Ser Tyr Ser Leu Pro 
            740                 745                 750         


Ile Val Leu Met Val Ala Trp Val Val Phe Ile Ala Ala Phe Val Lys 
        755                 760                 765             


Lys Leu Val Tyr Glu Lys Asp Leu Arg Leu His Glu Tyr Met Lys Met 
    770                 775                 780                 


Met Gly Val Asn Ser Cys Ser His Phe Phe Ala Trp Leu Ile Glu Ser 
785                 790                 795                 800 


Val Gly Phe Leu Leu Val Thr Ile Val Ile Leu Ile Ile Ile Leu Lys 
                805                 810                 815     


Phe Gly Asn Ile Leu Pro Lys Thr Asn Gly Phe Ile Leu Phe Leu Tyr 
            820                 825                 830         


Phe Ser Asp Tyr Ser Phe Ser Val Ile Ala Met Ser Tyr Leu Ile Ser 
        835                 840                 845             


Val Phe Phe Asn Asn Thr Asn Ile Ala Ala Leu Ile Gly Ser Leu Ile 
    850                 855                 860                 


Tyr Ile Ile Ala Phe Phe Pro Phe Ile Val Leu Val Thr Val Glu Asn 
865                 870                 875                 880 


Glu Leu Ser Tyr Val Leu Lys Val Phe Met Ser Leu Leu Ser Pro Thr 
                885                 890                 895     


Ala Phe Ser Tyr Ala Ser Gln Tyr Ile Ala Arg Tyr Glu Glu Gln Gly 
            900                 905                 910         


Ile Gly Leu Gln Trp Glu Asn Met Tyr Thr Ser Pro Val Gln Asp Asp 
        915                 920                 925             


Thr Thr Ser Phe Gly Trp Leu Cys Cys Leu Ile Leu Ala Asp Ser Phe 
    930                 935                 940                 


Ile Tyr Phe Leu Ile Ala Trp Tyr Val Arg Asn Val Phe Pro Gly Thr 
945                 950                 955                 960 


Tyr Gly Met Ala Ala Pro Trp Tyr Phe Pro Ile Leu Pro Ser Tyr Trp 
                965                 970                 975     


Lys Glu Arg Phe Gly Cys Ala Glu Val Lys Pro Glu Lys Ser Asn Gly 
            980                 985                 990         


Leu Met Phe Thr Asn Ile Met Met  Gln Asn Thr Asn Pro  Ser Ala Ser 
        995                 1000                 1005             


Pro Glu  Tyr Met Phe Ser Ser  Asn Ile Glu Pro Glu  Pro Lys Asp 
    1010                 1015                 1020             


Leu Thr  Val Gly Val Ala Leu  His Gly Val Thr Lys  Ile Tyr Gly 
    1025                 1030                 1035             


Ser Lys  Val Ala Val Asp Asn  Leu Asn Leu Asn Phe  Tyr Glu Gly 
    1040                 1045                 1050             


His Ile  Thr Ser Leu Leu Gly  Pro Asn Gly Ala Gly  Lys Thr Thr 
    1055                 1060                 1065             


Thr Ile  Ser Met Leu Thr Gly  Leu Phe Gly Ala Ser  Ala Gly Thr 
    1070                 1075                 1080             


Ile Phe  Val Tyr Gly Lys Asp  Ile Lys Thr Asp Leu  His Thr Val 
    1085                 1090                 1095             


Arg Lys  Asn Met Gly Val Cys  Met Gln His Asp Val  Leu Phe Ser 
    1100                 1105                 1110             


Tyr Leu  Thr Thr Lys Glu His  Leu Leu Leu Tyr Gly  Ser Ile Lys 
    1115                 1120                 1125             


Val Pro  His Trp Thr Lys Lys  Gln Leu His Glu Glu  Val Lys Arg 
    1130                 1135                 1140             


Thr Leu  Lys Asp Thr Gly Leu  Tyr Ser His Arg His  Lys Arg Val 
    1145                 1150                 1155             


Gly Thr  Leu Ser Gly Gly Met  Lys Arg Lys Leu Ser  Ile Ser Ile 
    1160                 1165                 1170             


Ala Leu  Ile Gly Gly Ser Arg  Val Val Ile Leu Asp  Glu Pro Ser 
    1175                 1180                 1185             


Thr Gly  Val Asp Pro Cys Ser  Arg Arg Ser Ile Trp  Asp Val Ile 
    1190                 1195                 1200             


Ser Lys  Asn Lys Thr Ala Arg  Thr Ile Ile Leu Ser  Thr His His 
    1205                 1210                 1215             


Leu Asp  Glu Ala Glu Val Leu  Ser Asp Arg Ile Ala  Phe Leu Glu 
    1220                 1225                 1230             


Gln Gly  Gly Leu Arg Cys Cys  Gly Ser Pro Phe Tyr  Leu Lys Glu 
    1235                 1240                 1245             


Ala Phe  Gly Asp Gly Tyr His  Leu Thr Leu Thr Lys  Lys Lys Ser 
    1250                 1255                 1260             


Pro Asn  Leu Asn Ala Asn Ala  Val Cys Asp Thr Met  Ala Val Thr 
    1265                 1270                 1275             


Ala Met  Ile Gln Ser His Leu  Pro Glu Ala Tyr Leu  Lys Glu Asp 
    1280                 1285                 1290             


Ile Gly  Gly Glu Leu Val Tyr  Val Leu Pro Pro Phe  Ser Thr Lys 
    1295                 1300                 1305             


Val Ser  Gly Ala Tyr Leu Ser  Leu Leu Arg Ala Leu  Asp Asn Gly 
    1310                 1315                 1320             


Met Gly  Asp Leu Asn Ile Gly  Cys Tyr Gly Ile Ser  Asp Thr Thr 
    1325                 1330                 1335             


Val Glu  Glu Val Phe Leu Asn  Leu Thr Lys Glu Ser  Gln Lys Asn 
    1340                 1345                 1350             


Ser Ala  Met Ser Leu Glu His  Leu Thr Gln Lys Lys  Ile Gly Asn 
    1355                 1360                 1365             


Ser Asn  Ala Asn Gly Ile Ser  Thr Pro Asp Asp Leu  Ser Val Ser 
    1370                 1375                 1380             


Ser Ser  Asn Phe Thr Asp Arg  Asp Asp Lys Ile Leu  Thr Arg Gly 
    1385                 1390                 1395             


Glu Arg  Leu Asp Gly Phe Gly  Leu Leu Leu Lys Lys  Ile Met Ala 
    1400                 1405                 1410             


Ile Leu  Ile Lys Arg Phe His  His Thr Arg Arg Asn  Trp Lys Gly 
    1415                 1420                 1425             


Leu Ile  Ala Gln Val Ile Leu  Pro Ile Val Phe Val  Thr Thr Ala 
    1430                 1435                 1440             


Met Gly  Leu Gly Thr Leu Arg  Asn Ser Ser Asn Ser  Tyr Pro Glu 
    1445                 1450                 1455             


Ile Gln  Ile Ser Pro Ser Leu  Tyr Gly Thr Ser Glu  Gln Thr Ala 
    1460                 1465                 1470             


Phe Tyr  Ala Asn Tyr His Pro  Ser Thr Glu Ala Leu  Val Ser Ala 
    1475                 1480                 1485             


Met Trp  Asp Phe Pro Gly Ile  Asp Asn Met Cys Leu  Asn Thr Ser 
    1490                 1495                 1500             


Asp Leu  Gln Cys Leu Asn Lys  Asp Ser Leu Glu Lys  Trp Asn Thr 
    1505                 1510                 1515             


Ser Gly  Glu Pro Ile Thr Asn  Phe Gly Val Cys Ser  Cys Ser Glu 
    1520                 1525                 1530             


Asn Val  Gln Glu Cys Pro Lys  Phe Asn Tyr Ser Pro  Pro His Arg 
    1535                 1540                 1545             


Arg Thr  Tyr Ser Ser Gln Val  Ile Tyr Asn Leu Thr  Gly Gln Arg 
    1550                 1555                 1560             


Val Glu  Asn Tyr Leu Ile Ser  Thr Ala Asn Glu Phe  Val Gln Lys 
    1565                 1570                 1575             


Arg Tyr  Gly Gly Trp Ser Phe  Gly Leu Pro Leu Thr  Lys Asp Leu 
    1580                 1585                 1590             


Arg Phe  Asp Ile Thr Gly Val  Pro Ala Asn Arg Thr  Leu Ala Lys 
    1595                 1600                 1605             


Val Trp  Tyr Asp Pro Glu Gly  Tyr His Ser Leu Pro  Ala Tyr Leu 
    1610                 1615                 1620             


Asn Ser  Leu Asn Asn Phe Leu  Leu Arg Val Asn Met  Ser Lys Tyr 
    1625                 1630                 1635             


Asp Ala  Ala Arg His Gly Ile  Ile Met Tyr Ser His  Pro Tyr Pro 
    1640                 1645                 1650             


Gly Val  Gln Asp Gln Glu Gln  Ala Thr Ile Ser Ser  Leu Ile Asp 
    1655                 1660                 1665             


Ile Leu  Val Ala Leu Ser Ile  Leu Met Gly Tyr Ser  Val Thr Thr 
    1670                 1675                 1680             


Ala Ser  Phe Val Thr Tyr Val  Val Arg Glu His Gln  Thr Lys Ala 
    1685                 1690                 1695             


Lys Gln  Leu Gln His Ile Ser  Gly Ile Gly Val Thr  Cys Tyr Trp 
    1700                 1705                 1710             


Val Thr  Asn Phe Ile Tyr Asp  Met Val Phe Tyr Leu  Val Pro Val 
    1715                 1720                 1725             


Ala Phe  Ser Ile Gly Ile Ile  Ala Ile Phe Lys Leu  Pro Ala Phe 
    1730                 1735                 1740             


Tyr Ser  Glu Asn Asn Leu Gly  Ala Val Ser Leu Leu  Leu Leu Leu 
    1745                 1750                 1755             


Phe Gly  Tyr Ala Thr Phe Ser  Trp Met Tyr Leu Leu  Ala Gly Leu 
    1760                 1765                 1770             


Phe His  Glu Thr Gly Met Ala  Phe Ile Thr Tyr Val  Cys Val Asn 
    1775                 1780                 1785             


Leu Phe  Phe Gly Ile Asn Ser  Ile Val Ser Leu Ser  Val Val Tyr 
    1790                 1795                 1800             


Phe Leu  Ser Lys Glu Lys Pro  Asn Asp Pro Thr Leu  Glu Leu Ile 
    1805                 1810                 1815             


Ser Glu  Thr Leu Lys Arg Ile  Phe Leu Ile Phe Pro  Gln Phe Cys 
    1820                 1825                 1830             


Phe Gly  Tyr Gly Leu Ile Glu  Leu Ser Gln Gln Gln  Ser Val Leu 
    1835                 1840                 1845             


Asp Phe  Leu Lys Ala Tyr Gly  Val Glu Tyr Pro Asn  Glu Thr Phe 
    1850                 1855                 1860             


Glu Met  Asn Lys Leu Gly Ala  Met Phe Val Ala Leu  Val Ser Gln 
    1865                 1870                 1875             


Gly Thr  Met Phe Phe Ser Leu  Arg Leu Leu Ile Asn  Glu Ser Leu 
    1880                 1885                 1890             


Ile Lys  Lys Leu Arg Leu Phe  Phe Arg Lys Phe Asn  Ser Ser His 
    1895                 1900                 1905             


Val Arg  Glu Thr Ile Asp Glu  Asp Glu Asp Val Arg  Ala Glu Arg 
    1910                 1915                 1920             


Leu Arg  Val Glu Ser Gly Ala  Ala Glu Phe Asp Leu  Val Gln Leu 
    1925                 1930                 1935             


Tyr Cys  Leu Thr Lys Thr Tyr  Gln Leu Ile His Lys  Lys Ile Ile 
    1940                 1945                 1950             


Ala Val  Asn Asn Ile Ser Ile  Gly Ile Pro Ala Gly  Glu Cys Phe 
    1955                 1960                 1965             


Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys Thr Thr  Ile Phe Lys 
    1970                 1975                 1980             


Met Leu  Thr Gly Asp Ile Ile  Pro Ser Ser Gly Asn  Ile Leu Ile 
    1985                 1990                 1995             


Arg Asn  Lys Thr Gly Ser Leu  Gly His Val Asp Ser  His Ser Ser 
    2000                 2005                 2010             


Leu Val  Gly Tyr Cys Pro Gln  Glu Asp Ala Leu Asp  Asp Leu Val 
    2015                 2020                 2025             


Thr Val  Glu Glu His Leu Tyr  Phe Tyr Ala Arg Val  His Gly Ile 
    2030                 2035                 2040             


Pro Glu  Lys Asp Ile Lys Glu  Thr Val His Lys Leu  Leu Arg Arg 
    2045                 2050                 2055             


Leu His  Leu Met Pro Phe Lys  Asp Arg Ala Thr Ser  Met Cys Ser 
    2060                 2065                 2070             


Tyr Gly  Thr Lys Arg Lys Leu  Ser Thr Ala Leu Ala  Leu Ile Gly 
    2075                 2080                 2085             


Lys Pro  Ser Ile Leu Leu Leu  Asp Glu Pro Ser Ser  Gly Met Asp 
    2090                 2095                 2100             


Pro Lys  Ser Lys Arg His Leu  Trp Lys Ile Ile Ser  Glu Glu Val 
    2105                 2110                 2115             


Gln Asn  Lys Cys Ser Val Ile  Leu Thr Ser His Ser  Met Glu Glu 
    2120                 2125                 2130             


Cys Glu  Ala Leu Cys Thr Arg  Leu Ala Ile Met Val  Asn Gly Lys 
    2135                 2140                 2145             


Phe Gln  Cys Ile Gly Ser Leu  Gln His Ile Lys Ser  Arg Phe Gly 
    2150                 2155                 2160             


Arg Gly  Phe Thr Val Lys Val  His Leu Lys Asn Asn  Lys Val Thr 
    2165                 2170                 2175             


Met Glu  Thr Leu Thr Lys Phe  Met Gln Leu His Phe  Pro Lys Thr 
    2180                 2185                 2190             


Tyr Leu  Lys Asp Gln His Leu  Ser Met Leu Glu Tyr  His Val Pro 
    2195                 2200                 2205             


Val Thr  Ala Gly Gly Val Ala  Asn Ile Phe Asp Leu  Leu Glu Thr 
    2210                 2215                 2220             


Asn Lys  Thr Ala Leu Asn Ile  Thr Asn Phe Leu Val  Ser Gln Thr 
    2225                 2230                 2235             


Thr Leu  Glu Glu Val Phe Ile  Asn Phe Ala Lys Asp  Gln Lys Ser 
    2240                 2245                 2250             


Tyr Glu  Thr Ala Asp Thr Ser  Ser Gln Gly Ser Thr  Ile Ser Val 
    2255                 2260                 2265             


Asp Ser  Gln Asp Asp Gln Met  Glu Ser 
    2270                 2275         


<210>  243
<211>  4446
<212>  DNA
<213>  Homo sapiens

<400>  243
tgccttgacc aggacttggg actttgcgaa aggatcgcgg ggcccggaga ggtgttggag     60

agcacaatgg ctgaacaagt ccttcctcag gctttgtatt tgagcaatat gcggaaagct    120

gtgaagatac gggagagaac tccagaagac atttttaaac ctactaatgg gatcattcat    180

cattttaaaa ccatgcaccg atacacactg gaaatgttca gaacttgcca gttttgtcct    240

cagtttcggg agatcatcca caaagccctc atcgacagaa acatccaggc caccctggaa    300

agccagaaga aactcaactg gtgtcgagaa gtccggaagc ttgtggcgct gaaaacgaac    360

ggtgacggca attgcctcat gcatgccact tctcagtaca tgtggggcgt tcaggacaca    420

gacttggtac tgaggaaggc gctgttcagc acgctcaagg aaacagacac acgcaacttt    480

aaattccgct ggcaactgga gtctctcaaa tctcaggaat ttgttgaaac ggggctttgc    540

tatgatactc ggaactggaa tgatgaatgg gacaatctta tcaaaatggc ttccacagac    600

acacccatgg cccgaagtgg acttcagtac aactcactgg aagaaataca catatttgtc    660

ctttgcaaca tcctcagaag gccaatcatt gtcatttcag acaaaatgct aagaagtttg    720

gaatcaggtt ccaatttcgc ccctttgaaa gtgggtggaa tttacttgcc tctccactgg    780

cctgcccagg aatgctacag ataccccatt gttctcggct atgacagcca tcattttgta    840

cccttggtga ccctgaagga cagtgggcct gaaatccgag ctgttccact tgttaacaga    900

gaccggggaa gatttgaaga cttaaaagtt cactttttga cagatcctga aaatgagatg    960

aaggagaagc tcttaaaaga gtacttaatg gtgatagaaa tccccgtcca aggctgggac   1020

catggcacaa ctcatctcat caatgccgca aagttggatg aagctaactt accaaaagaa   1080

atcaatctgg tagatgatta ctttgaactt gttcagcatg agtacaagaa atggcaggaa   1140

aacagcgagc aggggaggag agaggggcac gcccagaatc ccatggaacc ttccgtgccc   1200

cagctttctc tcatggatgt aaaatgtgaa acgcccaact gccccttctt catgtctgtg   1260

aacacccagc ctttatgcca tgagtgctca gagaggcggc aaaagaatca aaacaaactc   1320

ccaaagctga actccaagcc gggccctgag gggctccctg gcatggcgct cggggcctct   1380

cggggagaag cctatgagcc cttggcgtgg aaccctgagg agtccactgg ggggcctcat   1440

tcggccccac cgacagcacc cagccctttt ctgttcagtg agaccactgc catgaagtgc   1500

aggagccccg gctgcccctt cacactgaat gtgcagcaca acggattttg tgaacgttgc   1560

cacaacgccc ggcaacttca cgccagccac gccccagacc acacaaggca cttggatccc   1620

gggaagtgcc aagcctgcct ccaggatgtt accaggacat ttaatgggat ctgcagtact   1680

tgcttcaaaa ggactacagc agaggcctcc tccagcctca gcaccagcct ccctccttcc   1740

tgtcaccagc gttccaagtc agatccctcg cggctcgtcc ggagcccctc cccgcattct   1800

tgccacagag ctggaaacga cgcccctgct ggctgcctgt ctcaagctgc acggactcct   1860

ggggacagga cggggacgag caagtgcaga aaagccggct gcgtgtattt tgggactcca   1920

gaaaacaagg gcttttgcac actgtgtttc atcgagtaca gagaaaacaa acattttgct   1980

gctgcctcag ggaaagtcag tcccacagcg tccaggttcc agaacaccat tccgtgcctg   2040

gggagggaat gcggcaccct tggaagcacc atgtttgaag gatactgcca gaagtgtttc   2100

attgaagctc agaatcagag atttcatgag gccaaaagga cagaagagca actgagatcg   2160

agccagcgca gagatgtgcc tcgaaccaca caaagcacct caaggcccaa gtgcgcccgg   2220

gcctcctgca agaacatcct ggcctgccgc agcgaggagc tctgcatgga gtgtcagcat   2280

cccaaccaga ggatgggccc tggggcccac cggggtgagc ctgcccccga agaccccccc   2340

aagcagcgtt gccgggcccc cgcctgtgat cattttggca atgccaagtg caacggctac   2400

tgcaacgaat gctttcagtt caagcagatg tatggctaac cggaaacagg tgggtcacct   2460

cctgcaagaa gtggggcctc gagctgtcag tcatcatggt gctatcctct gaacccctca   2520

gctgccactg caacagtggg cttaagggtg tctgagcagg agaggaaaga taagctcttc   2580

gtggtgccca cgatgctcag gtttggtaac ccgggagtgt tcccaggtgg ccttagaaag   2640

caaagcttgt aactggcaag ggatgatgtc agattcagcc caaggttcct cctctcctac   2700

caagcaggag gccaggaact tctttggact tggaaggtgt gcggggactg gccgaggccc   2760

ctgcaccctg cgcatcagga ctgcttcatc gtcttggctg agaaagggaa aagacacaca   2820

agtcgcgtgg gttggagaag ccagagccat tccacctccc ctcccccagc atctctcaga   2880

gatgtgaagc cagatcctca tggcagcgag gccctctgca agaagctcaa ggaagctcag   2940

ggaaaatgga cgtattcaga gagtgtttgt agttcatggt ttttccctac ctgcccggtt   3000

cctttcctga ggacccggca gaaatgcaga accatccatg gactgtgatt ctgaggctgc   3060

tgagactgaa catgttcaca ttgacagaaa aacaagctgc tctttataat atgcaccttt   3120

taaaaaatta gaatatttta ctgggaagac gtgtaactct ttgggttatt actgtcttta   3180

cttctaaaga agttagcttg aactgaggag taaaagtgtg tacatatata atataccctt   3240

acattatgta tgagggattt ttttaaatta tattgaaatg ctgccctaga agtacaatag   3300

gaaggctaaa taataataac ctgttttctg gttgttgttg gggcatgagc ttgtgtatac   3360

actgcttgca taaactcaac cagctgcctt tttaaaggga gctctagtcc tttttgtgta   3420

attcacttta tttattttat tacaaacttc aagattattt aagtgaagat atttcttcag   3480

ctctggggaa aatgccacag tgttctcctg agagaacatc cttgctttga gtcaggctgt   3540

gggcaagttc ctgaccacag ggagtaaatt ggcctctttg atacactttt gcttgcctcc   3600

ccaggaaaga aggaattgca tccaaggtat acatacatat tcatcgatgt ttcgtgcttc   3660

tccttatgaa actccagcta tgtaataaaa aactatactc tgtgttctgt taatgcctct   3720

gagtgtccta cctccttgga gatgagatag ggaaggagca gggatgagac tggcaatggt   3780

cacagggaaa gatgtggcct tttgtgatgg ttttattttc tgttaacact gtgtcctggg   3840

ggggctggga agtcccctgc atcccatggt accctggtat tgggacagca aaagccagta   3900

accatgagta tgaggaaatc tctttctgtt gctggcttac agtttctctg tgtgctttgt   3960

ggttgctgtc atatttgctc tagaagaaaa aaaaaaaagg aggggaaatg cattttcccc   4020

agagataaag gctgccattt tgggggtctg tacttatggc ctgaaaatat ttgtgatcca   4080

taactctaca cagcctttac tcatactatt aggcacactt tccccttaga gccccctaag   4140

tttttcccag acgaatcttt ataatttctt tccaaagata ccaaataaac ttcagtgttt   4200

tcatctaatt ctcttaaagt tgatatctta atattttgtg ttgatcatta tttccattct   4260

taatgtgaaa aaaagtaatt atttatactt attataaaaa gtatttgaaa tttgcacatt   4320

taattgtccc taatagaaag ccacctattc tttgttggat ttcttcaagt ttttctaaat   4380

aaatgtaact tttcacaaga gtcaacatta aaaaataaat tatttaagaa caaaaaaaaa   4440

aaaaaa                                                              4446


<210>  244
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Ala Glu Gln Val Leu Pro Gln Ala Leu Tyr Leu Ser Asn Met Arg 
1               5                   10                  15      


Lys Ala Val Lys Ile Arg Glu Arg Thr Pro Glu Asp Ile Phe Lys Pro 
            20                  25                  30          


Thr Asn Gly Ile Ile His His Phe Lys Thr Met His Arg Tyr Thr Leu 
        35                  40                  45              


Glu Met Phe Arg Thr Cys Gln Phe Cys Pro Gln Phe Arg Glu Ile Ile 
    50                  55                  60                  


His Lys Ala Leu Ile Asp Arg Asn Ile Gln Ala Thr Leu Glu Ser Gln 
65                  70                  75                  80  


Lys Lys Leu Asn Trp Cys Arg Glu Val Arg Lys Leu Val Ala Leu Lys 
                85                  90                  95      


Thr Asn Gly Asp Gly Asn Cys Leu Met His Ala Thr Ser Gln Tyr Met 
            100                 105                 110         


Trp Gly Val Gln Asp Thr Asp Leu Val Leu Arg Lys Ala Leu Phe Ser 
        115                 120                 125             


Thr Leu Lys Glu Thr Asp Thr Arg Asn Phe Lys Phe Arg Trp Gln Leu 
    130                 135                 140                 


Glu Ser Leu Lys Ser Gln Glu Phe Val Glu Thr Gly Leu Cys Tyr Asp 
145                 150                 155                 160 


Thr Arg Asn Trp Asn Asp Glu Trp Asp Asn Leu Ile Lys Met Ala Ser 
                165                 170                 175     


Thr Asp Thr Pro Met Ala Arg Ser Gly Leu Gln Tyr Asn Ser Leu Glu 
            180                 185                 190         


Glu Ile His Ile Phe Val Leu Cys Asn Ile Leu Arg Arg Pro Ile Ile 
        195                 200                 205             


Val Ile Ser Asp Lys Met Leu Arg Ser Leu Glu Ser Gly Ser Asn Phe 
    210                 215                 220                 


Ala Pro Leu Lys Val Gly Gly Ile Tyr Leu Pro Leu His Trp Pro Ala 
225                 230                 235                 240 


Gln Glu Cys Tyr Arg Tyr Pro Ile Val Leu Gly Tyr Asp Ser His His 
                245                 250                 255     


Phe Val Pro Leu Val Thr Leu Lys Asp Ser Gly Pro Glu Ile Arg Ala 
            260                 265                 270         


Val Pro Leu Val Asn Arg Asp Arg Gly Arg Phe Glu Asp Leu Lys Val 
        275                 280                 285             


His Phe Leu Thr Asp Pro Glu Asn Glu Met Lys Glu Lys Leu Leu Lys 
    290                 295                 300                 


Glu Tyr Leu Met Val Ile Glu Ile Pro Val Gln Gly Trp Asp His Gly 
305                 310                 315                 320 


Thr Thr His Leu Ile Asn Ala Ala Lys Leu Asp Glu Ala Asn Leu Pro 
                325                 330                 335     


Lys Glu Ile Asn Leu Val Asp Asp Tyr Phe Glu Leu Val Gln His Glu 
            340                 345                 350         


Tyr Lys Lys Trp Gln Glu Asn Ser Glu Gln Gly Arg Arg Glu Gly His 
        355                 360                 365             


Ala Gln Asn Pro Met Glu Pro Ser Val Pro Gln Leu Ser Leu Met Asp 
    370                 375                 380                 


Val Lys Cys Glu Thr Pro Asn Cys Pro Phe Phe Met Ser Val Asn Thr 
385                 390                 395                 400 


Gln Pro Leu Cys His Glu Cys Ser Glu Arg Arg Gln Lys Asn Gln Asn 
                405                 410                 415     


Lys Leu Pro Lys Leu Asn Ser Lys Pro Gly Pro Glu Gly Leu Pro Gly 
            420                 425                 430         


Met Ala Leu Gly Ala Ser Arg Gly Glu Ala Tyr Glu Pro Leu Ala Trp 
        435                 440                 445             


Asn Pro Glu Glu Ser Thr Gly Gly Pro His Ser Ala Pro Pro Thr Ala 
    450                 455                 460                 


Pro Ser Pro Phe Leu Phe Ser Glu Thr Thr Ala Met Lys Cys Arg Ser 
465                 470                 475                 480 


Pro Gly Cys Pro Phe Thr Leu Asn Val Gln His Asn Gly Phe Cys Glu 
                485                 490                 495     


Arg Cys His Asn Ala Arg Gln Leu His Ala Ser His Ala Pro Asp His 
            500                 505                 510         


Thr Arg His Leu Asp Pro Gly Lys Cys Gln Ala Cys Leu Gln Asp Val 
        515                 520                 525             


Thr Arg Thr Phe Asn Gly Ile Cys Ser Thr Cys Phe Lys Arg Thr Thr 
    530                 535                 540                 


Ala Glu Ala Ser Ser Ser Leu Ser Thr Ser Leu Pro Pro Ser Cys His 
545                 550                 555                 560 


Gln Arg Ser Lys Ser Asp Pro Ser Arg Leu Val Arg Ser Pro Ser Pro 
                565                 570                 575     


His Ser Cys His Arg Ala Gly Asn Asp Ala Pro Ala Gly Cys Leu Ser 
            580                 585                 590         


Gln Ala Ala Arg Thr Pro Gly Asp Arg Thr Gly Thr Ser Lys Cys Arg 
        595                 600                 605             


Lys Ala Gly Cys Val Tyr Phe Gly Thr Pro Glu Asn Lys Gly Phe Cys 
    610                 615                 620                 


Thr Leu Cys Phe Ile Glu Tyr Arg Glu Asn Lys His Phe Ala Ala Ala 
625                 630                 635                 640 


Ser Gly Lys Val Ser Pro Thr Ala Ser Arg Phe Gln Asn Thr Ile Pro 
                645                 650                 655     


Cys Leu Gly Arg Glu Cys Gly Thr Leu Gly Ser Thr Met Phe Glu Gly 
            660                 665                 670         


Tyr Cys Gln Lys Cys Phe Ile Glu Ala Gln Asn Gln Arg Phe His Glu 
        675                 680                 685             


Ala Lys Arg Thr Glu Glu Gln Leu Arg Ser Ser Gln Arg Arg Asp Val 
    690                 695                 700                 


Pro Arg Thr Thr Gln Ser Thr Ser Arg Pro Lys Cys Ala Arg Ala Ser 
705                 710                 715                 720 


Cys Lys Asn Ile Leu Ala Cys Arg Ser Glu Glu Leu Cys Met Glu Cys 
                725                 730                 735     


Gln His Pro Asn Gln Arg Met Gly Pro Gly Ala His Arg Gly Glu Pro 
            740                 745                 750         


Ala Pro Glu Asp Pro Pro Lys Gln Arg Cys Arg Ala Pro Ala Cys Asp 
        755                 760                 765             


His Phe Gly Asn Ala Lys Cys Asn Gly Tyr Cys Asn Glu Cys Phe Gln 
    770                 775                 780                 


Phe Lys Gln Met Tyr Gly 
785                 790 


<210>  245
<211>  2076
<212>  DNA
<213>  Homo sapiens

<400>  245
cggggaaggg gagggaggag ggggacgagg gctctggcgg gtttggaggg gctgaacatc     60

gcggggtgtt ctggtgtccc ccgccccgcc tctccaaaaa gctacaccga cgcggaccgc    120

ggcggcgtcc tccctcgccc tcgcttcacc tcgcgggctc cgaatgcggg gagctcggat    180

gtccggtttc ctgtgaggct tttacctgac acccgccgcc tttccccggc actggctggg    240

agggcgccct gcaaagttgg gaacgcggag ccccggaccc gctcccgccg cctccggctc    300

gcccaggggg ggtcgccggg aggagcccgg gggagaggga ccaggagggg cccgcggcct    360

cgcaggggcg cccgcgcccc cacccctgcc cccgccagcg gaccggtccc ccacccccgg    420

tccttccacc atgcacttgc tgggcttctt ctctgtggcg tgttctctgc tcgccgctgc    480

gctgctcccg ggtcctcgcg aggcgcccgc cgccgccgcc gccttcgagt ccggactcga    540

cctctcggac gcggagcccg acgcgggcga ggccacggct tatgcaagca aagatctgga    600

ggagcagtta cggtctgtgt ccagtgtaga tgaactcatg actgtactct acccagaata    660

ttggaaaatg tacaagtgtc agctaaggaa aggaggctgg caacataaca gagaacaggc    720

caacctcaac tcaaggacag aagagactat aaaatttgct gcagcacatt ataatacaga    780

gatcttgaaa agtattgata atgagtggag aaagactcaa tgcatgccac gggaggtgtg    840

tatagatgtg gggaaggagt ttggagtcgc gacaaacacc ttctttaaac ctccatgtgt    900

gtccgtctac agatgtgggg gttgctgcaa tagtgagggg ctgcagtgca tgaacaccag    960

cacgagctac ctcagcaaga cgttatttga aattacagtg cctctctctc aaggccccaa   1020

accagtaaca atcagttttg ccaatcacac ttcctgccga tgcatgtcta aactggatgt   1080

ttacagacaa gttcattcca ttattagacg ttccctgcca gcaacactac cacagtgtca   1140

ggcagcgaac aagacctgcc ccaccaatta catgtggaat aatcacatct gcagatgcct   1200

ggctcaggaa gattttatgt tttcctcgga tgctggagat gactcaacag atggattcca   1260

tgacatctgt ggaccaaaca aggagctgga tgaagagacc tgtcagtgtg tctgcagagc   1320

ggggcttcgg cctgccagct gtggacccca caaagaacta gacagaaact catgccagtg   1380

tgtctgtaaa aacaaactct tccccagcca atgtggggcc aaccgagaat ttgatgaaaa   1440

cacatgccag tgtgtatgta aaagaacctg ccccagaaat caacccctaa atcctggaaa   1500

atgtgcctgt gaatgtacag aaagtccaca gaaatgcttg ttaaaaggaa agaagttcca   1560

ccaccaaaca tgcagctgtt acagacggcc atgtacgaac cgccagaagg cttgtgagcc   1620

aggattttca tatagtgaag aagtgtgtcg ttgtgtccct tcatattgga aaagaccaca   1680

aatgagctaa gattgtactg ttttccagtt catcgatttt ctattatgga aaactgtgtt   1740

gccacagtag aactgtctgt gaacagagag acccttgtgg gtccatgcta acaaagacaa   1800

aagtctgtct ttcctgaacc atgtggataa ctttacagaa atggactgga gctcatctgc   1860

aaaaggcctc ttgtaaagac tggttttctg ccaatgacca aacagccaag attttcctct   1920

tgtgatttct ttaaaagaat gactatataa tttatttcca ctaaaaatat tgtttctgca   1980

ttcattttta tagcaacaac aattggtaaa actcactgtg atcaatattt ttatatcatg   2040

caaaatatgt ttaaaataaa atgaaaattg tattat                             2076


<210>  246
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  246

Met His Leu Leu Gly Phe Phe Ser Val Ala Cys Ser Leu Leu Ala Ala 
1               5                   10                  15      


Ala Leu Leu Pro Gly Pro Arg Glu Ala Pro Ala Ala Ala Ala Ala Phe 
            20                  25                  30          


Glu Ser Gly Leu Asp Leu Ser Asp Ala Glu Pro Asp Ala Gly Glu Ala 
        35                  40                  45              


Thr Ala Tyr Ala Ser Lys Asp Leu Glu Glu Gln Leu Arg Ser Val Ser 
    50                  55                  60                  


Ser Val Asp Glu Leu Met Thr Val Leu Tyr Pro Glu Tyr Trp Lys Met 
65                  70                  75                  80  


Tyr Lys Cys Gln Leu Arg Lys Gly Gly Trp Gln His Asn Arg Glu Gln 
                85                  90                  95      


Ala Asn Leu Asn Ser Arg Thr Glu Glu Thr Ile Lys Phe Ala Ala Ala 
            100                 105                 110         


His Tyr Asn Thr Glu Ile Leu Lys Ser Ile Asp Asn Glu Trp Arg Lys 
        115                 120                 125             


Thr Gln Cys Met Pro Arg Glu Val Cys Ile Asp Val Gly Lys Glu Phe 
    130                 135                 140                 


Gly Val Ala Thr Asn Thr Phe Phe Lys Pro Pro Cys Val Ser Val Tyr 
145                 150                 155                 160 


Arg Cys Gly Gly Cys Cys Asn Ser Glu Gly Leu Gln Cys Met Asn Thr 
                165                 170                 175     


Ser Thr Ser Tyr Leu Ser Lys Thr Leu Phe Glu Ile Thr Val Pro Leu 
            180                 185                 190         


Ser Gln Gly Pro Lys Pro Val Thr Ile Ser Phe Ala Asn His Thr Ser 
        195                 200                 205             


Cys Arg Cys Met Ser Lys Leu Asp Val Tyr Arg Gln Val His Ser Ile 
    210                 215                 220                 


Ile Arg Arg Ser Leu Pro Ala Thr Leu Pro Gln Cys Gln Ala Ala Asn 
225                 230                 235                 240 


Lys Thr Cys Pro Thr Asn Tyr Met Trp Asn Asn His Ile Cys Arg Cys 
                245                 250                 255     


Leu Ala Gln Glu Asp Phe Met Phe Ser Ser Asp Ala Gly Asp Asp Ser 
            260                 265                 270         


Thr Asp Gly Phe His Asp Ile Cys Gly Pro Asn Lys Glu Leu Asp Glu 
        275                 280                 285             


Glu Thr Cys Gln Cys Val Cys Arg Ala Gly Leu Arg Pro Ala Ser Cys 
    290                 295                 300                 


Gly Pro His Lys Glu Leu Asp Arg Asn Ser Cys Gln Cys Val Cys Lys 
305                 310                 315                 320 


Asn Lys Leu Phe Pro Ser Gln Cys Gly Ala Asn Arg Glu Phe Asp Glu 
                325                 330                 335     


Asn Thr Cys Gln Cys Val Cys Lys Arg Thr Cys Pro Arg Asn Gln Pro 
            340                 345                 350         


Leu Asn Pro Gly Lys Cys Ala Cys Glu Cys Thr Glu Ser Pro Gln Lys 
        355                 360                 365             


Cys Leu Leu Lys Gly Lys Lys Phe His His Gln Thr Cys Ser Cys Tyr 
    370                 375                 380                 


Arg Arg Pro Cys Thr Asn Arg Gln Lys Ala Cys Glu Pro Gly Phe Ser 
385                 390                 395                 400 


Tyr Ser Glu Glu Val Cys Arg Cys Val Pro Ser Tyr Trp Lys Arg Pro 
                405                 410                 415     


Gln Met Ser 
            


<210>  247
<211>  1699
<212>  DNA
<213>  Homo sapiens

<400>  247
ggccctccct ggaggagaac tgaaacttag ggtggggact gtagaaaggg gcggagagat     60

cagccgccca gccaggagtt aagctgaggt cgtctgagcc ctgcgacagc ctggacagca    120

actcaggatg gcatcaggca gggcacgctg cacccgaaaa ctccggaact gggtggtgga    180

gcaagtggag agtgggcagt ttcccggagt gtgctgggat gatacagcta agaccatgtt    240

ccggattccc tggaaacatg caggcaagca ggacttccgg gaggaccagg atgctgcctt    300

cttcaaggcc tgggcaatat ttaagggaaa gtataaggag ggggacacag gaggtccagc    360

tgtctggaag actcgcctgc gctgtgcact caacaagagt tctgaattta aggaggttcc    420

tgagaggggc cgcatggatg ttgctgagcc ctacaaggtg tatcagttgc tgccaccagg    480

aatcgtctct ggccagccag ggactcagaa agtaccatca aagcgacagc acagttctgt    540

gtcctctgag aggaaggagg aagaggatgc catgcagaac tgcacactca gtccctctgt    600

gctccaggac tccctcaata atgaggagga gggggccagt gggggagcag tccattcaga    660

cattgggagc agcagcagca gcagcagccc tgagccacag gaagttacag acacaactga    720

ggcccccttt caaggggatc agaggtccct ggagtttctg cttcctccag agccagacta    780

ctcactgctg ctcaccttca tctacaacgg gcgcgtggtg ggcgaggccc aggtgcaaag    840

cctggattgc cgccttgtgg ctgagccctc aggctctgag agcagcatgg agcaggtgct    900

gttccccaag cctggcccac tggagcccac gcagcgcctg ctgagccagc ttgagagggg    960

catcctagtg gccagcaacc cccgaggcct cttcgtgcag cgcctttgcc ccatccccat   1020

ctcctggaat gcaccccagg ctccacctgg gccaggcccg catctgctgc ccagcaacga   1080

gtgcgtggag ctcttcagaa ccgcctactt ctgcagagac ttggtcaggt actttcaggg   1140

cctgggcccc ccaccgaagt tccaggtaac actgaatttc tgggaagaga gccatggctc   1200

cagccatact ccacagaatc ttatcacagt gaagatggag caggcctttg cccgatactt   1260

gctggagcag actccagagc agcaggcagc cattctgtcc ctggtgtaga gcctggggga   1320

cccatcttcc acctcacctc tttgttcttc ctgtctcctt tgaagtagac tcattcttca   1380

cacgattgac ctgtcctctt tgtgataatt ctcagtagtt gtccgtgata atcgtgtcct   1440

gaaaatcctc gcacacactg gctggtggag aactcaaggc taatttttta tccttttttt   1500

tttttaattt tgagatatac gccctctttc atctgtaagg gactaggaaa ttccaaatgg   1560

tgtgaaccca gggggccttt ccctcttccc tgacctccca actctaaagc caagcacttt   1620

atattttcct cttagatatt cactaaggac ttaaaataaa attttattga aagaggaaaa   1680

aaaaaaaaaa aaaaaaaaa                                                1699


<210>  248
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Ala Ser Gly Arg Ala Arg Cys Thr Arg Lys Leu Arg Asn Trp Val 
1               5                   10                  15      


Val Glu Gln Val Glu Ser Gly Gln Phe Pro Gly Val Cys Trp Asp Asp 
            20                  25                  30          


Thr Ala Lys Thr Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln 
        35                  40                  45              


Asp Phe Arg Glu Asp Gln Asp Ala Ala Phe Phe Lys Ala Trp Ala Ile 
    50                  55                  60                  


Phe Lys Gly Lys Tyr Lys Glu Gly Asp Thr Gly Gly Pro Ala Val Trp 
65                  70                  75                  80  


Lys Thr Arg Leu Arg Cys Ala Leu Asn Lys Ser Ser Glu Phe Lys Glu 
                85                  90                  95      


Val Pro Glu Arg Gly Arg Met Asp Val Ala Glu Pro Tyr Lys Val Tyr 
            100                 105                 110         


Gln Leu Leu Pro Pro Gly Ile Val Ser Gly Gln Pro Gly Thr Gln Lys 
        115                 120                 125             


Val Pro Ser Lys Arg Gln His Ser Ser Val Ser Ser Glu Arg Lys Glu 
    130                 135                 140                 


Glu Glu Asp Ala Met Gln Asn Cys Thr Leu Ser Pro Ser Val Leu Gln 
145                 150                 155                 160 


Asp Ser Leu Asn Asn Glu Glu Glu Gly Ala Ser Gly Gly Ala Val His 
                165                 170                 175     


Ser Asp Ile Gly Ser Ser Ser Ser Ser Ser Ser Pro Glu Pro Gln Glu 
            180                 185                 190         


Val Thr Asp Thr Thr Glu Ala Pro Phe Gln Gly Asp Gln Arg Ser Leu 
        195                 200                 205             


Glu Phe Leu Leu Pro Pro Glu Pro Asp Tyr Ser Leu Leu Leu Thr Phe 
    210                 215                 220                 


Ile Tyr Asn Gly Arg Val Val Gly Glu Ala Gln Val Gln Ser Leu Asp 
225                 230                 235                 240 


Cys Arg Leu Val Ala Glu Pro Ser Gly Ser Glu Ser Ser Met Glu Gln 
                245                 250                 255     


Val Leu Phe Pro Lys Pro Gly Pro Leu Glu Pro Thr Gln Arg Leu Leu 
            260                 265                 270         


Ser Gln Leu Glu Arg Gly Ile Leu Val Ala Ser Asn Pro Arg Gly Leu 
        275                 280                 285             


Phe Val Gln Arg Leu Cys Pro Ile Pro Ile Ser Trp Asn Ala Pro Gln 
    290                 295                 300                 


Ala Pro Pro Gly Pro Gly Pro His Leu Leu Pro Ser Asn Glu Cys Val 
305                 310                 315                 320 


Glu Leu Phe Arg Thr Ala Tyr Phe Cys Arg Asp Leu Val Arg Tyr Phe 
                325                 330                 335     


Gln Gly Leu Gly Pro Pro Pro Lys Phe Gln Val Thr Leu Asn Phe Trp 
            340                 345                 350         


Glu Glu Ser His Gly Ser Ser His Thr Pro Gln Asn Leu Ile Thr Val 
        355                 360                 365             


Lys Met Glu Gln Ala Phe Ala Arg Tyr Leu Leu Glu Gln Thr Pro Glu 
    370                 375                 380                 


Gln Gln Ala Ala Ile Leu Ser Leu Val 
385                 390             


<210>  249
<211>  3998
<212>  DNA
<213>  Homo sapiens

<400>  249
ccgggagccc gggcgccctg gagtgaggag gaccgggagc tggctctgga ggctgcggag     60

gcgacgccgg agagaacgaa gcctcggctg ggagcggatc tttcgaagat ggtttggctg    120

ccttggagat ttggagatct gatgccacga tgaggactca cacacggggg gctcccagtg    180

tgtttttcat atatttgctt tgctttgtgt cagcctacat caccgacgag aacccagaag    240

ttatgattcc cttcaccaat gccaactacg acagccatcc catgctgtac ttctccaggg    300

cagaagtggc ggagctgcag ctcagggctg ccagctcgca cgagcacatt gcagcccgcc    360

tcacggaggc tgtgcacacg atgctgtcca gccccttgga atacctccct ccctgggatc    420

ccaaggacta cagtgcccgc tggaatgaaa tttttggaaa caacttgggt gccttggcaa    480

tgttctgtgt gctgtatcct gagaacattg aagcccgaga catggccaaa gactacatgg    540

agaggatggc agcgcagcct agttggttgg tgaaagatgc tccttgggat gaggtcccgc    600

ttgctcactc cctggttggt tttgccactg cttatgactt cttgtacaac tacctgagca    660

agacacaaca ggagaagttt cttgaagtga ttgccaatgc ctcagggtat atgtatgaaa    720

cttcatacag gagaggatgg ggatttcaat acctgcacaa tcatcagccc accaactgta    780

tggctttgct cacgggaagc ctagtcctga tgaatcaagg atatcttcaa gaagcctact    840

tatggaccaa acaagttctg accatcatgg agaaatctct ggtcttgctc agggaggtga    900

cggatggctc cctctatgaa ggagttgcgt atggcagcta caccactaga tcactcttcc    960

aatacatgtt tctcgtccag aggcacttca acatcaacca ctttggccat ccgtggctta   1020

aacaacactt tgcatttatg tatagaacca tcctgccagg gtttcaaagg actgtggcta   1080

ttgcggactc aaattacaac tggttttatg gtccagaaag ccaattagtg ttccttgata   1140

aatttgtcat gcgtaatggc agtggtaact ggctagctga ccaaatcaga aggaaccgtg   1200

tggtggaagg tccaggaaca ccatccaaag ggcagcgctg gtgcactctg cacacagaat   1260

ttctctggta tgatggcagc ttgaaatcgg ttcctcctcc agactttggc acccctacac   1320

tgcattattt tgaagactgg ggtgtcgtga cttatggaag tgcactacct gcagaaatca   1380

atagatcttt cctttccttc aagtctggaa aactgggggg acgtgcaata tatgacattg   1440

tccacagaaa caaatacaaa gattggatca aaggatggag aaattttaat gcagggcatg   1500

aacatcctga tcaaaactca tttacttttg ctcccaatgg tgtgcctttc attactgagg   1560

ctctgtacgg gccaaagtac accttcttca acaatgtttt gatgttttcc ccagctgtgt   1620

caaagagctg cttttctccc tgggtgggtc aggtcacaga agactgctca tcaaaatggt   1680

ctaaatacaa gcatgacctg gcagctagtt gtcaggggag ggtggttgca gcagaggaga   1740

aaaatggggt ggttttcatc cgaggagaag gtgtgggagc ttataacccc cagctcaacc   1800

tgaagaatgt tcagaggaat ctcatcctcc tacatccaca gctgcttctc cttgtagacc   1860

aaatacacct gggagaggag agtcccttgg agacagcagc gagcttcttc cataatgtgg   1920

atgttccttt tgaggagact gtggtagatg gtgtccatgg ggctttcatc aggcagagag   1980

atggtctcta taaaatgtac tggatggacg atactggcta cagcgagaaa gcaacctttg   2040

cctcagtgac atatcctcgg ggctatccct acaacgggac aaactatgtg aatgtcacca   2100

tgcacctccg aagtcccatc accagggcag cttacctctt catagggcca tctatagatg   2160

ttcagagctt cactgtccac ggagactctc agcaactgga tgtgttcata gccaccagca   2220

aacatgccta cgccacatac ctgtggacag gtgaggccac aggacagtct gcctttgcac   2280

aggtcattgc tgatcgtcac aaaattctgt ttgaccggaa ttcagccatc aagagcagca   2340

ttgtccctga ggtgaaggac tatgctgcta ttgtggaaca gaacttgcag cattttaaac   2400

cagtgtttca gctgctggag aagcagatac tgtcccgagt ccggaacaca gctagcttta   2460

ggaagactgc tgaacgcctg ctgagatttt cagataagag acagactgag gaggccattg   2520

acaggatttt tgccatatca cagcaacagc agcagcaaag caagtcaaag aaaaaccgaa   2580

gggcaggcaa acgctataaa tttgtggatg ctgtccctga tatttttgca cagattgaag   2640

tcaatgagaa aaagattaga cagaaagctc agattttggc acagaaagaa ctacccatag   2700

atgaagatga agaaatgaaa gaccttttag attttgcaga tgtaacatac gagaaacata   2760

aaaatggggg cttgattaaa ggccggtttg gacaggcacg gatggtgaca actacacaca   2820

gcagggcccc atcactgtct gcttcctata ccaggttgtt cctgattctg aacattgcta   2880

ttttctttgt catgttggca atgcaactga cttatttcca gagggcccag agcctacatg   2940

gccaaagatg tctttatgca gttcttctca tagatagctg tattttatta tggttgtact   3000

cttcttgttc ccaatcacag tgttagcact gaagctataa attacctggt cattttgtga   3060

tcacaagagt ctatgcaaaa aaaaaaattt ctttacccca gattatcaga tttttttccc   3120

tcagattcat tttaacaaat taagggaaga tattttgaca caagaaagca ggaacgtgga   3180

gaaattggag caggaaaaga aattatcaaa gcaatagaaa tagcttggtg gtcctatggt   3240

gtttttggaa gtatttggca ttgctaattg agcagtccat atagtactac ttttagaaga   3300

aacaaaaagt ctatttttta aagtaatgtt ttttcttatg agaaaaaggt ttagatagaa   3360

ttgggtttta ttaatattaa tttaatgcta ttagcaattt ccatatacta tattgtggaa   3420

aagactgaag aatacaattc tgagaaatat aaaaaaattt taatggtata ctcatgttga   3480

aagataaatg ttgctaagtc ctggtatgat ggtgtgagct tccttgggga agtacttctt   3540

gagttatgta actaacagga tgttttacta cagatctgga tggctattca gataacatgg   3600

caaaaaatga tagcagaaga tcattaaaaa cttaaaatat attttattag aaaacattta   3660

tctatgaatg aatatttcct tgatgctggt ctctgcacac atatgcttgg ttacttgcat   3720

gcattcattg gttgttcaat aagtgagatg attacagata atactgtatt ttccttatat   3780

ggaaaaccgt tatagaccca ataacaacta aacctttcaa aagaaaatat tttctattat   3840

gaatgttgat tttcatacca aagaagatgg agagtctaaa atttggatat gattcttatg   3900

tttttttaat agaaaacctt cttcaagttt attttcctaa ataaacatca taattgtgaa   3960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                           3998


<210>  250
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


Pro Trp Asp Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr 
145                 150                 155                 160 


Ala Tyr Asp Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys 
                165                 170                 175     


Phe Leu Glu Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser 
            180                 185                 190         


Tyr Arg Arg Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr 
        195                 200                 205             


Asn Cys Met Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly 
    210                 215                 220                 


Tyr Leu Gln Glu Ala Tyr Leu Trp Thr Lys Gln Val Leu Thr Ile Met 
225                 230                 235                 240 


Glu Lys Ser Leu Val Leu Leu Arg Glu Val Thr Asp Gly Ser Leu Tyr 
                245                 250                 255     


Glu Gly Val Ala Tyr Gly Ser Tyr Thr Thr Arg Ser Leu Phe Gln Tyr 
            260                 265                 270         


Met Phe Leu Val Gln Arg His Phe Asn Ile Asn His Phe Gly His Pro 
        275                 280                 285             


Trp Leu Lys Gln His Phe Ala Phe Met Tyr Arg Thr Ile Leu Pro Gly 
    290                 295                 300                 


Phe Gln Arg Thr Val Ala Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr 
305                 310                 315                 320 


Gly Pro Glu Ser Gln Leu Val Phe Leu Asp Lys Phe Val Met Arg Asn 
                325                 330                 335     


Gly Ser Gly Asn Trp Leu Ala Asp Gln Ile Arg Arg Asn Arg Val Val 
            340                 345                 350         


Glu Gly Pro Gly Thr Pro Ser Lys Gly Gln Arg Trp Cys Thr Leu His 
        355                 360                 365             


Thr Glu Phe Leu Trp Tyr Asp Gly Ser Leu Lys Ser Val Pro Pro Pro 
    370                 375                 380                 


Asp Phe Gly Thr Pro Thr Leu His Tyr Phe Glu Asp Trp Gly Val Val 
385                 390                 395                 400 


Thr Tyr Gly Ser Ala Leu Pro Ala Glu Ile Asn Arg Ser Phe Leu Ser 
                405                 410                 415     


Phe Lys Ser Gly Lys Leu Gly Gly Arg Ala Ile Tyr Asp Ile Val His 
            420                 425                 430         


Arg Asn Lys Tyr Lys Asp Trp Ile Lys Gly Trp Arg Asn Phe Asn Ala 
        435                 440                 445             


Gly His Glu His Pro Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly 
    450                 455                 460                 


Val Pro Phe Ile Thr Glu Ala Leu Tyr Gly Pro Lys Tyr Thr Phe Phe 
465                 470                 475                 480 


Asn Asn Val Leu Met Phe Ser Pro Ala Val Ser Lys Ser Cys Phe Ser 
                485                 490                 495     


Pro Trp Val Gly Gln Val Thr Glu Asp Cys Ser Ser Lys Trp Ser Lys 
            500                 505                 510         


Tyr Lys His Asp Leu Ala Ala Ser Cys Gln Gly Arg Val Val Ala Ala 
        515                 520                 525             


Glu Glu Lys Asn Gly Val Val Phe Ile Arg Gly Glu Gly Val Gly Ala 
    530                 535                 540                 


Tyr Asn Pro Gln Leu Asn Leu Lys Asn Val Gln Arg Asn Leu Ile Leu 
545                 550                 555                 560 


Leu His Pro Gln Leu Leu Leu Leu Val Asp Gln Ile His Leu Gly Glu 
                565                 570                 575     


Glu Ser Pro Leu Glu Thr Ala Ala Ser Phe Phe His Asn Val Asp Val 
            580                 585                 590         


Pro Phe Glu Glu Thr Val Val Asp Gly Val His Gly Ala Phe Ile Arg 
        595                 600                 605             


Gln Arg Asp Gly Leu Tyr Lys Met Tyr Trp Met Asp Asp Thr Gly Tyr 
    610                 615                 620                 


Ser Glu Lys Ala Thr Phe Ala Ser Val Thr Tyr Pro Arg Gly Tyr Pro 
625                 630                 635                 640 


Tyr Asn Gly Thr Asn Tyr Val Asn Val Thr Met His Leu Arg Ser Pro 
                645                 650                 655     


Ile Thr Arg Ala Ala Tyr Leu Phe Ile Gly Pro Ser Ile Asp Val Gln 
            660                 665                 670         


Ser Phe Thr Val His Gly Asp Ser Gln Gln Leu Asp Val Phe Ile Ala 
        675                 680                 685             


Thr Ser Lys His Ala Tyr Ala Thr Tyr Leu Trp Thr Gly Glu Ala Thr 
    690                 695                 700                 


Gly Gln Ser Ala Phe Ala Gln Val Ile Ala Asp Arg His Lys Ile Leu 
705                 710                 715                 720 


Phe Asp Arg Asn Ser Ala Ile Lys Ser Ser Ile Val Pro Glu Val Lys 
                725                 730                 735     


Asp Tyr Ala Ala Ile Val Glu Gln Asn Leu Gln His Phe Lys Pro Val 
            740                 745                 750         


Phe Gln Leu Leu Glu Lys Gln Ile Leu Ser Arg Val Arg Asn Thr Ala 
        755                 760                 765             


Ser Phe Arg Lys Thr Ala Glu Arg Leu Leu Arg Phe Ser Asp Lys Arg 
    770                 775                 780                 


Gln Thr Glu Glu Ala Ile Asp Arg Ile Phe Ala Ile Ser Gln Gln Gln 
785                 790                 795                 800 


Gln Gln Gln Ser Lys Ser Lys Lys Asn Arg Arg Ala Gly Lys Arg Tyr 
                805                 810                 815     


Lys Phe Val Asp Ala Val Pro Asp Ile Phe Ala Gln Ile Glu Val Asn 
            820                 825                 830         


Glu Lys Lys Ile Arg Gln Lys Ala Gln Ile Leu Ala Gln Lys Glu Leu 
        835                 840                 845             


Pro Ile Asp Glu Asp Glu Glu Met Lys Asp Leu Leu Asp Phe Ala Asp 
    850                 855                 860                 


Val Thr Tyr Glu Lys His Lys Asn Gly Gly Leu Ile Lys Gly Arg Phe 
865                 870                 875                 880 


Gly Gln Ala Arg Met Val Thr Thr Thr His Ser Arg Ala Pro Ser Leu 
                885                 890                 895     


Ser Ala Ser Tyr Thr Arg Leu Phe Leu Ile Leu Asn Ile Ala Ile Phe 
            900                 905                 910         


Phe Val Met Leu Ala Met Gln Leu Thr Tyr Phe Gln Arg Ala Gln Ser 
        915                 920                 925             


Leu His Gly Gln Arg Cys Leu Tyr Ala Val Leu Leu Ile Asp Ser Cys 
    930                 935                 940                 


Ile Leu Leu Trp Leu Tyr Ser Ser Cys Ser Gln Ser Gln Cys 
945                 950                 955             


<210>  251
<211>  6216
<212>  DNA
<213>  Homo sapiens

<400>  251
gcgggcaagg cgggcggagc gcactggaac tcaagggggc gcacagcggc gcgctcgcac     60

cgctcggctc cgcgcggctc taggaggtgg cggcggtggc ggtggcggcg gtggcggcgg    120

cggcggcggc ggggcgcagg gctgagcgag cgtccgggtt ccggggctcc ggggaaggcg    180

gttgcagctc ctgagtgcag cgcggcttcc tgccactgtc ccggcccggc cacctctctg    240

tcatggctct ggcggacagc acacgtggat tacccaacgg gggcggcggc gggggcggca    300

gtggctcctc gtcgtcctcc gcggagccac cgctcttccc cgacatcgtg gagctgaacg    360

tggggggcca ggtgtacgtg acccggcgct gcacggtggt gtcggtgccc gactcgctgc    420

tctggcgcat gttcacgcag cagcagccgc aggagctggc ccgggacagc aaaggccgct    480

tctttctgga ccgggacggc ttcctcttcc gctacatcct ggattacctg cgggacttgc    540

agctcgtgct gcccgactac ttccccgagc gcagccggct gcagcgcgag gccgagtact    600

tcgagctgcc agagctcgtg cgccgcctcg gggcgcccca gcagcccggc ccggggccgc    660

cgccctcgcg gcgcggggtg cacaaggagg gctcgctggg tgacgagctg ctgccgcttg    720

gctactcgga gcccgaacag caggagggcg cctctgccgg ggcgccgtcg cccacgctgg    780

agctggctag ccgcagtccg tccgggggcg cggcgggccc gctgctcacg ccgtcccagt    840

cgctggacgg cagccggcgc tcgggctaca tcaccatcgg ctaccgcggc tcctacacca    900

tcgggcggga cgcgcaggcg gacgccaagt tccggcgagt ggcgcgcatc accgtttgcg    960

gaaagacgtc gctggccaag gaggtgtttg gggacaccct gaacgaaagc cgggaccccg   1020

accgtccccc ggagcgctac acctcgcgct attacctcaa gttcaacttc ctggagcagg   1080

ccttcgacaa gctgtccgag tcgggcttcc acatggtggc gtgcagctcc acgggcacct   1140

gcgcctttgc cagcagcacc gaccagagcg aggacaagat ctggaccagc tacaccgagt   1200

acgtcttctg cagggagtga gctccccaga ccccctcgcc actccagcgc ccagtccttc   1260

tcctgcccga gagatgatta cagagcctct tgtcccacct ttgtcccctg gctgctgccc   1320

tcccattctc cccctccagt agtagctggg tgagacctgt ccgcccacct tccctccact   1380

acagaacctg cagccgcaaa tcctctgggc tgcttcgtct tctttggacc tcctgaaccg   1440

agagaaccca gaggaacccc caccccaccc ccacctacca ctccatgctt tctctactcc   1500

ctgcctcaaa ccacccctcc cccagatggt acttcagttt ggatctattg ggggagtgtg   1560

gccacagacc gggggatgat tgaattgttc agaacctgat tggaccgtgt ccaatgtgcg   1620

gaagatttcc ttgaaatctt ctcaagctct tatgactcac tgggggttta agagatcagg   1680

attggttcca ctgtctgggg ttagtgtttt acaaggtcat tacacagtct ttttgacctc   1740

ttttgaaggt agagttttag aaggctggat ggaagattct gagcctggaa ttaggacccc   1800

atggaggcag ttcagtaact aaactaataa agttttgaaa agttacacgt aaagtagaag   1860

aatctagtgc gtgggacagt aaaggatcct ttctcgtaca gaataaaagg tctcagcctg   1920

tagcttaaac ttatagaaag tgatccgcct gcctgcagag gcgccctttt cagctgctgc   1980

tcgccagaag cccttgattc cactggttga catggcagca gttactggca agagggagaa   2040

aggacgctgc cgcctaagag tgcaaggctg ctcaggtctc caagcgccgt aggaggtcac   2100

ctggcagtga ctgtagggag ctgggtcata gtgcacgtcg tgggtattag gaaagcctgt   2160

attctttcaa tgaatgtcag taggaccttc ctttagctgt aagacttggt gggcggggtg   2220

gggtggggag ggaggaaagg gtaggaaggg tgggaaggga gaagcagaca tagtcattta   2280

tgatttgaaa gttggaagtt tgtaccatct gtttgagtat atgcacattt aaaaaatatc   2340

atatagtaaa tgcaaacatg ccaagtattt tataaagatt aataacagac ctactcttac   2400

ctggcagttt acttaactta ctgttttgag tcctaaactt agagttgtta atgcttatat   2460

ataatctaac caaagagtta cccagtaggg ttttagtttt tgaactttta ttttcttgtt   2520

gattataaat cctgattttg gaatctattg cgcaaaagaa gtttcatttt ggttacttag   2580

acctaagatc acttattaaa aatccttatt ttctccaagc ccagcaaacg ttgacttctg   2640

ggcaaacctg aaaacctgaa aatgccactt tcatgcagtt tgtttgaagt taagtggaat   2700

cctttcaaat gacgagctgc agagaactca gcaccaaggg ctgcctatct gtagatagct   2760

gtaaaatgga atatttttaa atgaaggcaa ataagtactt aaaagtgagc tgagcaataa   2820

aatggtccaa taataggtaa atgcaacaga aacagaagga gacctggttg ccttatgcct   2880

ttactcttac atggaataaa ttcccaatgc atatcctatg taaaccataa gtgaagggaa   2940

ataaacctcg tcatgctcca tgctgtgagg tgtcctttgg atattctgtg atgacagaga   3000

agcctatttt gttttgtttt cagcatcttt ctctgatgta cgtttttaag gattttgtaa   3060

gagctgtttt cagtgtttaa attagtgcta tttttccttg tttttaaaaa tgaatctcgt   3120

actgtatctt actatgtcca tacagatgtt acaaatcgac agttttattc ttagactcat   3180

gtgatccaag ctgtatatac catatataaa cattttacat gaatcattta gttttttaat   3240

tcatttacta atgctataaa atttcctata ttaccccagt aatttgcatc agctggttta   3300

tatactaaag caacatgttt tgatgagttt cttacatcct tatcgaggaa ttgggttagg   3360

aaaaaataca taattgtaaa actgagtttg ctgtattata ctttttttct tgagtattag   3420

ttgtattact aatcatatgt tgattaactg tctacttaaa gtcaaggtac ctgtattttt   3480

aatccactaa ttttttttta gttgggaaat agatttcaag tcttttatta gactaacatt   3540

ttttgagaag taaaattgac tttatataca aagcctgtaa ttttaggcga aatggaagca   3600

gaaatctagg aagttgtgct tgcttgtatg gtctcagact aagtaatgca tcagaattca   3660

tctgtttgaa gcctgaaata atttaggact ctgattcact gaccaaaagt cagtgttgca   3720

gagatttctc taccccgtat ggtattttgt tagattgttc aacaggaagc acatgattga   3780

gaacatcttg ggacagacca aaaccactga cagatggcaa ggctcggcga ttctgatttc   3840

ccttctcaaa tctgctcaac tccaagagtc ttgagaaact gctaaaattt tgcctctgtc   3900

actcaagtct tacaaatgtt atcttgtaaa cctttgaggt gaactattcc actgtcttgt   3960

acataggcat cttattcact gcaccctgtc acacccagca ccccccgccc cgcacattat   4020

ttgaaagact gggaatttaa tggttaggga cagtaaatct acttcttttt ccagggacga   4080

ctgtcccctc taaagttaaa gtcaatacaa gaaaactgtc tatttttagc ctaaagtaaa   4140

ggctgtgaag aaaattcatt ttacattggg tagacagtaa aaaacaagta aaataacttg   4200

acatgagcac ctttagatcc cttcccctcc atgggctttg ggccacagaa tgaacctttg   4260

aggcctgtaa agtggattgt aatttcctat aagctgtaat agtggaggta ttgtgggttc   4320

atttgagtaa gccctccaaa gataccattc aaataacctg ggagaatgtc ataaattatt   4380

cagataatta tcactgcatg aatctgattc agaggcatgc atttacatat gttgccctaa   4440

ttaccatttg atgatcataa atacaagtga atgacattgg acttttagta acaaacttaa   4500

tttttaaaaa agtgtagaca atggtggtta aaaaaaaaaa aaacaggtgc caggttctgt   4560

gtgtttgcac caagtaattg acatgttttt tgtttaatac atgtggacca tgaacagtat   4620

tcattctact ttttcaaatg atatgctgta gaaaatattc cttgaagatg tgagatttaa   4680

aaatttttcc ctttcaatgt tgttttaatt gtatttctta cttggttttt ttgattgata   4740

gcacagtgat aaatcataat actagacaaa attgtcttct ctttcaaacc agagccatat   4800

atatgtctgt atatatggga cctactgctt ctctgaggaa atgcataatc tgttaatatc   4860

agacaaaatg agcaattggc agtgctcata atatattcca atttttattg gaattttcga   4920

tggaatgtta tttcaataaa gccatgtaag gtgaaacttt gataactttt tactcttcaa   4980

gttagggtaa attctgatcc aatattcaat tcatttgtgt actcccacat gcaaaatgct   5040

aaattacaat gcagacatta agaaaaagta ttgactggag gggttgaatt ccttgagaat   5100

ttattttata gtctaaatca caaatacttt actcaattta gtttttaaaa tagtaaactg   5160

aatatttttg ttgtaagcct atcagagtca atccttcgtt tggaattgtt ttcctgtttt   5220

tccttactat aaatcattta aaaactgaat tcattttctt agatggcata agtctgtctc   5280

ttgagaaata agtaaaatac tcctattttc agtatctgta gcacctgaaa taggtctttg   5340

tatagccaga aacaagttat gttgaagtta gcttttcttt gtcaacagtt ttggacaata   5400

aaaatctgaa agtattaaca cttgattttc tactggggcc cttcaaactt ggttggaaga   5460

aattcaacca gaatatctac attagagtat aatcatgtgt ggtaggaaga tggactagtt   5520

aatcaagatt tgttgtcact taaatttttt gtgatttttt tccaagccag tttttttaaa   5580

ttctaaatgt gttttgaggt atgggtacat taattgtaat gtaaactatt atacaactgt   5640

ttttgcgact ttataggcag gtaaattttg ctattactat tgaatacaaa tgacaattca   5700

tttatgacca ctcaaacagc gttagtaacc atttagtgac aaaggattaa aacatccatc   5760

tggatgttaa ttttgaagat gtaaattata tgttgtttaa atttttccag gcatctgaaa   5820

accttatctg ctagacaatg taagattcac acagagttat ctgggattct gattttttaa   5880

atagtacata tcattaaacc attttctcta aatgtaagaa gagcagaaaa aatcttataa   5940

gattatcaga tttttctaat gacacagaaa tgtaagaaaa aaatcccttt atattgaaaa   6000

aagatgcagt caaagtcttt tcagacatgc ccaaactttg agaattcctt caaccatcta   6060

atgctataaa gatttttgtt cttcctgttc acaaccagtt gtataacaga aatactagct   6120

actgttttcc ttcctgtgtg tgaagtaatg aatcattgat tatgtgactt gttatgtatt   6180

caattaaaca ctaaagaata aaacattcac tccttt                             6216


<210>  252
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Ala Leu Ala Asp Ser Thr Arg Gly Leu Pro Asn Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Ser Ser Ser Ser Ser Ala Glu Pro Pro Leu Phe 
            20                  25                  30          


Pro Asp Ile Val Glu Leu Asn Val Gly Gly Gln Val Tyr Val Thr Arg 
        35                  40                  45              


Arg Cys Thr Val Val Ser Val Pro Asp Ser Leu Leu Trp Arg Met Phe 
    50                  55                  60                  


Thr Gln Gln Gln Pro Gln Glu Leu Ala Arg Asp Ser Lys Gly Arg Phe 
65                  70                  75                  80  


Phe Leu Asp Arg Asp Gly Phe Leu Phe Arg Tyr Ile Leu Asp Tyr Leu 
                85                  90                  95      


Arg Asp Leu Gln Leu Val Leu Pro Asp Tyr Phe Pro Glu Arg Ser Arg 
            100                 105                 110         


Leu Gln Arg Glu Ala Glu Tyr Phe Glu Leu Pro Glu Leu Val Arg Arg 
        115                 120                 125             


Leu Gly Ala Pro Gln Gln Pro Gly Pro Gly Pro Pro Pro Ser Arg Arg 
    130                 135                 140                 


Gly Val His Lys Glu Gly Ser Leu Gly Asp Glu Leu Leu Pro Leu Gly 
145                 150                 155                 160 


Tyr Ser Glu Pro Glu Gln Gln Glu Gly Ala Ser Ala Gly Ala Pro Ser 
                165                 170                 175     


Pro Thr Leu Glu Leu Ala Ser Arg Ser Pro Ser Gly Gly Ala Ala Gly 
            180                 185                 190         


Pro Leu Leu Thr Pro Ser Gln Ser Leu Asp Gly Ser Arg Arg Ser Gly 
        195                 200                 205             


Tyr Ile Thr Ile Gly Tyr Arg Gly Ser Tyr Thr Ile Gly Arg Asp Ala 
    210                 215                 220                 


Gln Ala Asp Ala Lys Phe Arg Arg Val Ala Arg Ile Thr Val Cys Gly 
225                 230                 235                 240 


Lys Thr Ser Leu Ala Lys Glu Val Phe Gly Asp Thr Leu Asn Glu Ser 
                245                 250                 255     


Arg Asp Pro Asp Arg Pro Pro Glu Arg Tyr Thr Ser Arg Tyr Tyr Leu 
            260                 265                 270         


Lys Phe Asn Phe Leu Glu Gln Ala Phe Asp Lys Leu Ser Glu Ser Gly 
        275                 280                 285             


Phe His Met Val Ala Cys Ser Ser Thr Gly Thr Cys Ala Phe Ala Ser 
    290                 295                 300                 


Ser Thr Asp Gln Ser Glu Asp Lys Ile Trp Thr Ser Tyr Thr Glu Tyr 
305                 310                 315                 320 


Val Phe Cys Arg Glu 
                325 


<210>  253
<211>  1103
<212>  DNA
<213>  Homo sapiens

<400>  253
cacagagccc gggccgcagg cacctcctcg ccagctcttc cgctcctctc acagccgcca     60

gacccgcctg ctgagcccca tggcccgcgc tgctctctcc gccgccccca gcaatccccg    120

gctcctgcga gtggcactgc tgctcctgct cctggtagcc gctggccggc gcgcagcagg    180

agcgtccgtg gccactgaac tgcgctgcca gtgcttgcag accctgcagg gaattcaccc    240

caagaacatc caaagtgtga acgtgaagtc ccccggaccc cactgcgccc aaaccgaagt    300

catagccaca ctcaagaatg ggcggaaagc ttgcctcaat cctgcatccc ccatagttaa    360

gaaaatcatc gaaaagatgc tgaacagtga caaatccaac tgaccagaag ggaggaggaa    420

gctcactggt ggctgttcct gaaggaggcc ctgcccttat aggaacagaa gaggaaagag    480

agacacagct gcagaggcca cctggattgt gcctaatgtg tttgagcatc gcttaggaga    540

agtcttctat ttatttattt attcattagt tttgaagatt ctatgttaat attttaggtg    600

taaaataatt aagggtatga ttaactctac ctgcacactg tcctattata ttcattcttt    660

ttgaaatgtc aaccccaagt tagttcaatc tggattcata tttaatttga aggtagaatg    720

ttttcaaatg ttctccagtc attatgttaa tatttctgag gagcctgcaa catgccagcc    780

actgtgatag aggctggcgg atccaagcaa atggccaatg agatcattgt gaaggcaggg    840

gaatgtatgt gcacatctgt tttgtaactg tttagatgaa tgtcagttgt tatttattga    900

aatgatttca cagtgtgtgg tcaacatttc tcatgttgaa actttaagaa ctaaaatgtt    960

ctaaatatcc cttggacatt ttatgtcttt cttgtaaggc atactgcctt gtttaatggt   1020

agttttacag tgtttctggc ttagaacaaa ggggcttaat tattgatgtt ttcatagaga   1080

atataaaaat aaagcactta tag                                           1103


<210>  254
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210>  255
<211>  1159
<212>  DNA
<213>  Homo sapiens

<400>  255
agtgccccag gagctatgac aagcaaagga acatacttgc ctggagatag cctttgcgat     60

atttaaatgt ccgtggatac agaaatctct gcaggcaagt tgctccagag catattgcag    120

gacaagcctg taacgaatag ttaaattcac ggcatctgga ttcctaatcc ttttccgaaa    180

tggcaggtgt gagtgcctgt ataaaatatt ctatgtttac cttcaacttc ttgttctggc    240

tatgtggtat cttgatccta gcattagcaa tatgggtacg agtaagcaat gactctcaag    300

caatttttgg ttctgaagat gtaggctcta gctcctacgt tgctgtggac atattgattg    360

ctgtaggtgc catcatcatg attctgggct tcctgggatg ctgcggtgct ataaaagaaa    420

gtcgctgcat gcttctgttg tttttcatag gcttgcttct gatcctgctc ctgcaggtgg    480

cgacaggtat cctaggagct gttttcaaat ctaagtctga tcgcattgtg aatgaaactc    540

tctatgaaaa cacaaagctt ttgagcgcca caggggaaag tgaaaaacaa ttccaggaag    600

ccataattgt gtttcaagaa gagtttaaat gctgcggttt ggtcaatgga gctgctgatt    660

ggggaaataa ttttcaacac tatcctgaat tatgtgcctg tctagataag cagagaccat    720

gccaaagcta taatggaaaa caagtttaca aagagacctg tatttctttc ataaaagact    780

tcttggcaaa aaatttgatt atagttattg gaatatcatt tggactggca gttattgaga    840

tactgggttt ggtgttttct atggtcctgt attgccagat cgggaacaaa tgaatctgtg    900

gatgcatcaa cctatcgtca gtcaaacccc tttaaaatgt tgctttggct ttgtaaattt    960

aaatatgtaa gtgctatata agtcaggagc agctgtcttt ttaaaatgtc tcggctagct   1020

agaccacaga tatcttctag acatattgaa cacatttaag atttgaggga tataagggaa   1080

aatgatatga atgtgtattt ttactcaaaa taaaagtaac tgtttacgtt aaaaaaaaaa   1140

aaaaaaaaaa aaaaaaaaa                                                1159


<210>  256
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Ala Gly Val Ser Ala Cys Ile Lys Tyr Ser Met Phe Thr Phe Asn 
1               5                   10                  15      


Phe Leu Phe Trp Leu Cys Gly Ile Leu Ile Leu Ala Leu Ala Ile Trp 
            20                  25                  30          


Val Arg Val Ser Asn Asp Ser Gln Ala Ile Phe Gly Ser Glu Asp Val 
        35                  40                  45              


Gly Ser Ser Ser Tyr Val Ala Val Asp Ile Leu Ile Ala Val Gly Ala 
    50                  55                  60                  


Ile Ile Met Ile Leu Gly Phe Leu Gly Cys Cys Gly Ala Ile Lys Glu 
65                  70                  75                  80  


Ser Arg Cys Met Leu Leu Leu Phe Phe Ile Gly Leu Leu Leu Ile Leu 
                85                  90                  95      


Leu Leu Gln Val Ala Thr Gly Ile Leu Gly Ala Val Phe Lys Ser Lys 
            100                 105                 110         


Ser Asp Arg Ile Val Asn Glu Thr Leu Tyr Glu Asn Thr Lys Leu Leu 
        115                 120                 125             


Ser Ala Thr Gly Glu Ser Glu Lys Gln Phe Gln Glu Ala Ile Ile Val 
    130                 135                 140                 


Phe Gln Glu Glu Phe Lys Cys Cys Gly Leu Val Asn Gly Ala Ala Asp 
145                 150                 155                 160 


Trp Gly Asn Asn Phe Gln His Tyr Pro Glu Leu Cys Ala Cys Leu Asp 
                165                 170                 175     


Lys Gln Arg Pro Cys Gln Ser Tyr Asn Gly Lys Gln Val Tyr Lys Glu 
            180                 185                 190         


Thr Cys Ile Ser Phe Ile Lys Asp Phe Leu Ala Lys Asn Leu Ile Ile 
        195                 200                 205             


Val Ile Gly Ile Ser Phe Gly Leu Ala Val Ile Glu Ile Leu Gly Leu 
    210                 215                 220                 


Val Phe Ser Met Val Leu Tyr Cys Gln Ile Gly Asn Lys 
225                 230                 235         


<210>  257
<211>  2849
<212>  DNA
<213>  Homo sapiens

<400>  257
gcggccgcgg ctcccgagct cctcgggctc tgggtcccgg cgcccctccg gccgcgagtc     60

ccacgcgcca cccccgggcg ccctcgacgg tggatctagc ggcggcgagg aggcgggtcc    120

cggccccggc gaaccccagt cccggccccc ggccccgggc ccagcttcgg catggatgtg    180

aggttctacc ccgcggcggc cggggaccct gccagcctgg acttcgcgca gtgcctgggg    240

tactacggct acagcaagtt tggaaataat aataactata tgaatatggc tgaggcgaac    300

aatgcgttct tcgctgccag tgagcagaca ttccacacac caagccttgg ggacgaggaa    360

ttcgaaattc caccaatcac gcctcctcca gagtcagacc ctgccctagg catgccggat    420

gtactgctac cctttcaagc cctcagcgat ccattgcctt cccagggaag tgaattcaca    480

ccccagtttc cccctcaaag cctggacctc ccttccatta caatctcaag aaatctcgtg    540

gaacaagatg gcgtgcttca tagcagtggg ttgcatatgg atcagagcca cacacaagtg    600

tcccagtacc ggcaggatcc ctccctgatc atgcggtcca tcgtccacat gaccgatgct    660

gcgcgttctg gggtcatgcc tcctgcccag ctcaccacca tcaaccagtc tcagctcagc    720

gcccagttgg ggttgaattt gggaggtgcc agtatgcctc acacatctcc ttcacctcca    780

gcaagcaaat cagccactcc ctccccttcc agctccatca atgaagagga tgctgatgaa    840

gccaacagag ccattggaga gaaaagagct gctccagact ctggcaagaa gcccaagact    900

ccaaagaaaa agaaaaagaa agatcccaat gagccacaga agccagtgtc agcatatgcc    960

ctgtttttca gagacacaca ggctgcaatt aaaggtcaaa accccaatgc aacctttgga   1020

gaggtctcaa aaattgtagc atctatgtgg gacagccttg gagaagaaca aaagcaggta   1080

tataaaagga aaacagaagc tgccaaaaaa gaatacctga aggccctggc ggcatacagg   1140

gccagcctcg tttctaaggc tgctgctgag tcagcagaag cccagaccat ccgttctgtt   1200

cagcagaccc tggcgtcgac caatctaaca tcctctctcc ttctcaacac tccactgtct   1260

caacatggaa cagtgtcagc atcacctcag actctccagc aatccctccc taggtcaatc   1320

gctcccaaac ccttaaccat gagactcccc atgaaccaga ttgtcacatc agtcaccatt   1380

gcagccaaca tgccctcgaa cattggggct ccactgataa gctccatggg aacgaccatg   1440

gttggctcag caccctccac ccaagtgagt ccttcggtgc aaacccagca gcatcagatg   1500

caattgcagc agcagcagca gcagcaacaa caacagatgc aacagatgca gcagcagcaa   1560

ctccagcagc accaaatgca tcagcaaatc cagcagcaga tgcagcagca gcatttccag   1620

caccacatgc agcagcacct gcagcagcag cagcagcatc tccagcagca aattaatcaa   1680

cagcagctgc agcagcagct gcagcagcgc ctccagctgc agcagctgca acacatgcag   1740

caccagtctc agccttctcc tcggcagcac tcccctgtcg cctctcagat aacatccccc   1800

atccctgcca tcgggagccc ccagccagcc tctcagcagc accagtcgca aatacagtct   1860

cagacacaga ctcaagtatt atcgcaggct atacctacaa tatgtgaatc aaactgttta   1920

atgaatcctg ggacatactg atgactataa actggcctct ctgagtcata gaaaaatggc   1980

cttatttctc cagaagtgag taaaccacac ttccaggcta tctgaactcc tgaagcccta   2040

aaaataaaaa gcacagttgt aactacctga aatatgaaga tccagtttca tacaaacatt   2100

tgtatgacgt gaatagttga tggcattttt ttgtcatgaa aaaaataatg taaatcacag   2160

acttttgcca aagctcttat tttttttcct aaatctctcc agaaaaaaaa tgcaagtgac   2220

taaattcaat tattgactaa tttccacttt ttatccatga cttctccaaa tcaaaccaca   2280

gtatatgttg taacaatatc tatgaccact gttagcccat tatattcatt ccaattagaa   2340

gaaatgtgaa tactatattc cgtgttttga gtgacaagtt tcgaaaaata aaaacactgt   2400

atttttaaaa gggaaatgca cttaaatgaa aacagttatt acaaaagtta agatttaaaa   2460

agaaaaagca agagttttta ttatgatgta ataccagtag aatatttaaa aggcacacca   2520

catctgaata atcaatgtaa atattttctt tcaaagttgt aagttttcat atcatgtgct   2580

gtaaagtttt cctaaatgag gctttaacgt aaacactggt gacataaacc attcattgct   2640

acgttgctta ttgtgttttt atgctgtttt atactttttt atgagttatg atagcagcaa   2700

ttaagttgtt tgtattttgc ttaactaaaa caaaaatgct tttatcttgc tatagaataa   2760

acacatttca gtaaaaactg tggactgtat tttgatgcaa caacaaagaa actgttcact   2820

tttcaaataa aatgatatgt cagatttca                                     2849


<210>  258
<211>  576
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Asp Val Arg Phe Tyr Pro Ala Ala Ala Gly Asp Pro Ala Ser Leu 
1               5                   10                  15      


Asp Phe Ala Gln Cys Leu Gly Tyr Tyr Gly Tyr Ser Lys Phe Gly Asn 
            20                  25                  30          


Asn Asn Asn Tyr Met Asn Met Ala Glu Ala Asn Asn Ala Phe Phe Ala 
        35                  40                  45              


Ala Ser Glu Gln Thr Phe His Thr Pro Ser Leu Gly Asp Glu Glu Phe 
    50                  55                  60                  


Glu Ile Pro Pro Ile Thr Pro Pro Pro Glu Ser Asp Pro Ala Leu Gly 
65                  70                  75                  80  


Met Pro Asp Val Leu Leu Pro Phe Gln Ala Leu Ser Asp Pro Leu Pro 
                85                  90                  95      


Ser Gln Gly Ser Glu Phe Thr Pro Gln Phe Pro Pro Gln Ser Leu Asp 
            100                 105                 110         


Leu Pro Ser Ile Thr Ile Ser Arg Asn Leu Val Glu Gln Asp Gly Val 
        115                 120                 125             


Leu His Ser Ser Gly Leu His Met Asp Gln Ser His Thr Gln Val Ser 
    130                 135                 140                 


Gln Tyr Arg Gln Asp Pro Ser Leu Ile Met Arg Ser Ile Val His Met 
145                 150                 155                 160 


Thr Asp Ala Ala Arg Ser Gly Val Met Pro Pro Ala Gln Leu Thr Thr 
                165                 170                 175     


Ile Asn Gln Ser Gln Leu Ser Ala Gln Leu Gly Leu Asn Leu Gly Gly 
            180                 185                 190         


Ala Ser Met Pro His Thr Ser Pro Ser Pro Pro Ala Ser Lys Ser Ala 
        195                 200                 205             


Thr Pro Ser Pro Ser Ser Ser Ile Asn Glu Glu Asp Ala Asp Glu Ala 
    210                 215                 220                 


Asn Arg Ala Ile Gly Glu Lys Arg Ala Ala Pro Asp Ser Gly Lys Lys 
225                 230                 235                 240 


Pro Lys Thr Pro Lys Lys Lys Lys Lys Lys Asp Pro Asn Glu Pro Gln 
                245                 250                 255     


Lys Pro Val Ser Ala Tyr Ala Leu Phe Phe Arg Asp Thr Gln Ala Ala 
            260                 265                 270         


Ile Lys Gly Gln Asn Pro Asn Ala Thr Phe Gly Glu Val Ser Lys Ile 
        275                 280                 285             


Val Ala Ser Met Trp Asp Ser Leu Gly Glu Glu Gln Lys Gln Val Tyr 
    290                 295                 300                 


Lys Arg Lys Thr Glu Ala Ala Lys Lys Glu Tyr Leu Lys Ala Leu Ala 
305                 310                 315                 320 


Ala Tyr Arg Ala Ser Leu Val Ser Lys Ala Ala Ala Glu Ser Ala Glu 
                325                 330                 335     


Ala Gln Thr Ile Arg Ser Val Gln Gln Thr Leu Ala Ser Thr Asn Leu 
            340                 345                 350         


Thr Ser Ser Leu Leu Leu Asn Thr Pro Leu Ser Gln His Gly Thr Val 
        355                 360                 365             


Ser Ala Ser Pro Gln Thr Leu Gln Gln Ser Leu Pro Arg Ser Ile Ala 
    370                 375                 380                 


Pro Lys Pro Leu Thr Met Arg Leu Pro Met Asn Gln Ile Val Thr Ser 
385                 390                 395                 400 


Val Thr Ile Ala Ala Asn Met Pro Ser Asn Ile Gly Ala Pro Leu Ile 
                405                 410                 415     


Ser Ser Met Gly Thr Thr Met Val Gly Ser Ala Pro Ser Thr Gln Val 
            420                 425                 430         


Ser Pro Ser Val Gln Thr Gln Gln His Gln Met Gln Leu Gln Gln Gln 
        435                 440                 445             


Gln Gln Gln Gln Gln Gln Gln Met Gln Gln Met Gln Gln Gln Gln Leu 
    450                 455                 460                 


Gln Gln His Gln Met His Gln Gln Ile Gln Gln Gln Met Gln Gln Gln 
465                 470                 475                 480 


His Phe Gln His His Met Gln Gln His Leu Gln Gln Gln Gln Gln His 
                485                 490                 495     


Leu Gln Gln Gln Ile Asn Gln Gln Gln Leu Gln Gln Gln Leu Gln Gln 
            500                 505                 510         


Arg Leu Gln Leu Gln Gln Leu Gln His Met Gln His Gln Ser Gln Pro 
        515                 520                 525             


Ser Pro Arg Gln His Ser Pro Val Ala Ser Gln Ile Thr Ser Pro Ile 
    530                 535                 540                 


Pro Ala Ile Gly Ser Pro Gln Pro Ala Ser Gln Gln His Gln Ser Gln 
545                 550                 555                 560 


Ile Gln Ser Gln Thr Gln Thr Gln Val Leu Ser Gln Val Ser Ile Phe 
                565                 570                 575     


<210>  259
<211>  2892
<212>  DNA
<213>  Homo sapiens

<400>  259
agccccaaac tcaccacctg gccgtggaca cctgtgtcag catgtgggac ctggttctct     60

ccatcgcctt gtctgtgggg tgcactggtg ccgtgcccct catccagtct cggattgtgg    120

gaggctggga gtgtgagaag cattcccaac cctggcaggt ggctgtgtac agtcatggat    180

gggcacactg tgggggtgtc ctggtgcacc cccagtgggt gctcacagct gcccattgcc    240

taaagaagaa tagccaggtc tggctgggtc ggcacaacct gtttgagcct gaagacacag    300

gccagagggt ccctgtcagc cacagcttcc cacacccgct ctacaatatg agccttctga    360

agcatcaaag ccttagacca gatgaagact ccagccatga cctcatgctg ctccgcctgt    420

cagagcctgc caagatcaca gatgttgtga aggtcctggg cctgcccacc caggagccag    480

cactggggac cacctgctac gcctcaggct ggggcagcat cgaaccagag gagttcttgc    540

gccccaggag tcttcagtgt gtgagcctcc atctcctgtc caatgacatg tgtgctagag    600

cttactctga gaaggtgaca gagttcatgt tgtgtgctgg gctctggaca ggtggtaaag    660

acacttgtgg ggtgagtcat ccctactccc aacatctgga ggggaaaggg tgattctggg    720

ggtccacttg tctgtaatgg tgtgcttcaa ggtatcacat catggggccc tgagccatgt    780

gccctgcctg aaaagcctgc tgtgtacacc aaggtggtgc attaccggaa gtggatcaag    840

gacaccatcg cagccaaccc ctgagtgccc ctgtcccacc cctacctcta gtaaatttaa    900

gtccacctca cgttctggca tcacttggcc tttctggatg ctggacacct gaagcttgga    960

actcacctgg ccgaagctcg agcctcctga gtcctactga cctgtgcttt ctggtgtgga   1020

gtccagggct gctaggaaaa ggaatgggca gacacaggtg tatgccaatg tttctgaaat   1080

gggtataatt tcgtcctctc cttcggaaca ctggctgtct ctgaagactt ctcgctcagt   1140

ttcagtgagg acacacacaa agacgtgggt gaccatgttg tttgtggggt gcagagatgg   1200

gaggggtggg gcccaccctg gaagagtgga cagtgacaca aggtggacac tctctacaga   1260

tcactgagga taagctggag ccacaatgca tgaggcacac acacagcaag gatgacgctg   1320

taaacatagc ccacgctgtc ctgggggcac tgggaagcct agataaggcc gtgagcagaa   1380

agaaggggag gatcctccta tgttgttgaa ggagggacta gggggagaaa ctgaaagctg   1440

attaattaca ggaggtttgt tcaggtcccc caaaccaccg tcagatttga tgatttccta   1500

gcaggactta cagaaataaa gagctatcat gctgtggttt attatggttt gttacattga   1560

tgggatacat actgaaatca gcaaacaaaa cagatgtata gattagagtg tggagaaaac   1620

agaggaaaac ttgcagttac gaagactggc aacttggctt tactaagttt tcagactggc   1680

aggaagtcaa acctattagg ctgaggacct tgtggagtgt agctgatcca gctgatagag   1740

gaactagcca ggtgggggcc tttccctttg gatggggggc atatctgaca gttattctct   1800

ccaagtggag acttacggac agcatataat tctccctgca aggatgtatg ataatatgta   1860

caaagtaatt ccaactgagg aagctcacct gatccttagt gtccaaggtt tttactgggg   1920

gtctgtagga cgagtatgga gtacttgaat aattgacctg aagtcctcag acctgaggtt   1980

ccctagagtt caaacagata cagcatggtc cagagtccca gatgtacaaa aacagggatt   2040

catcacaaat cccatcttta gcatgaaggg tctggcatgg cccaaggccc caagtatatc   2100

aaggcacttg ggcagaacat gccaaggaat caaatgtcat ctcccaggag ttattcaagg   2160

gtgagccctt tacttgggat gtacaggctt tgagcagtgc agggctgctg agtcaacctt   2220

ttattgtaca ggggatgagg gaaagggaga ggatgaggaa gcccccctgg ggatttggtt   2280

tggtcttgtg atcaggtggt ctatggggct atccctacaa agaagaatcc agaaataggg   2340

gcacattgag gaatgatact gagcccaaag agcattcaat cattgtttta tttgccttct   2400

tttcacacca ttggtgaggg agggattacc accctggggt tatgaagatg gttgaacacc   2460

ccacacatag caccggagat atgagatcaa cagtttctta gccatagaga ttcacagccc   2520

agagcaggag gacgctgcac accatgcagg atgacatggg ggatgcgctc gggattggtg   2580

tgaagaagca aggactgtta gaggcaggct ttatagtaac aagacggtgg ggcaaactct   2640

gatttccgtg ggggaatgtc atggtcttgc tttactaagt tttgagactg gcaggtagtg   2700

aaactcatta ggctgagaac cttgtggaat gcagctgacc cagctgatag aggaagtagc   2760

caggtgggag cctttcccag tgggtgtggg acatatctgg caagattttg tggcactcct   2820

ggttacagat actggggcag caaataaaac tgaatcttgt tttcagacct taaaaaaaaa   2880

aaaaaaaaaa aa                                                       2892


<210>  260
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ala Val Pro Leu Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Ala Val Tyr Ser His Gly Trp Ala 
        35                  40                  45              


His Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Lys Lys Asn Ser Gln Val Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Glu Pro Glu Asp Thr Gly Gln Arg Val Pro Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asn Met Ser Leu Leu Lys His Gln Ser Leu Arg 
            100                 105                 110         


Pro Asp Glu Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Lys Ile Thr Asp Val Val Lys Val Leu Gly Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Arg Pro Arg Ser Leu Gln Cys Val Ser Leu 
                165                 170                 175     


His Leu Leu Ser Asn Asp Met Cys Ala Arg Ala Tyr Ser Glu Lys Val 
            180                 185                 190         


Thr Glu Phe Met Leu Cys Ala Gly Leu Trp Thr Gly Gly Lys Asp Thr 
        195                 200                 205             


Cys Gly Val Ser His Pro Tyr Ser Gln His Leu Glu Gly Lys Gly 
    210                 215                 220             


<210>  261
<211>  1027
<212>  DNA
<213>  Homo sapiens

<400>  261
gggcaagagt tgggcaaaaa aatcaaggta tttggtcccg gaacaaagct tatcattaca     60

gataaacaac ttgatgcaga tgtttccccc aagcccacta tttttcttcc ttcaattgct    120

gaaacaaagc tccagaaggc tggaacatac ctttgtcttc ttgagaaatt tttccctgat    180

gttattaaga tacattggca agaaaagaag agcaacacga ttctgggatc ccaggagggg    240

aacaccatga agactaacga cacatacatg aaatttagct ggttaacggt gccagaaaag    300

tcactggaca aagaacacag atgtatcgtc agacatgaga ataataaaaa cggagttgat    360

caagaaatta tctttcctcc aataaagaca gatgtcatca caatggatcc caaagacaat    420

tgttcaaaag atgcaaatga tacactactg ctgcagctca caaacacctc tgcatattac    480

atgtacctcc tcctgctcct caagagtgtg gtctattttg ccatcatcac ctgctgtctg    540

cttagaagaa cggctttctg ctgcaatgga gagaaatcat aacagacggt ggcacaagga    600

ggccatcttt tcctcatcgg ttattgtccc tagaagcgtc ttctgaggat ctagttgggc    660

tttctttctg ggtttgggcc atttcagttc tcatgtgtgt actattctat cattattgta    720

taacggtttt caaaccagtg ggcacacaga gaacctcact ctgtaataac aatgaggaat    780

agccacggcg atctccagca ccaatctctc catgttttcc acagctcctc cagccaaccc    840

aaatagcgcc tgctatagtg tagacatcct gcggcttcta gccttgtccc tctcttagtg    900

ttctttaatc agataactgc ctggaagcct ttcattttac acgccctgaa gcagtcttct    960

ttgctagttg aattatgtgg tgtgtttttc cgtaataagc aaaataaatt taaaaaaatg   1020

aaaagtt                                                             1027


<210>  262
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Gln Met Phe Pro Pro Ser Pro Leu Phe Phe Phe Leu Gln Leu Leu 
1               5                   10                  15      


Lys Gln Ser Ser Arg Arg Leu Glu His Thr Phe Val Phe Leu Arg Asn 
            20                  25                  30          


Phe Ser Leu Met Leu Leu Arg Tyr Ile Gly Lys Lys Arg Arg Ala Thr 
        35                  40                  45              


Arg Phe Trp Asp Pro Arg Arg Gly Thr Pro 
    50                  55              


<210>  263
<211>  2215
<212>  DNA
<213>  Homo sapiens

<400>  263
agcttttctc ttctgtcaac cccacacgcc tttggcacaa tgaagtgggt aacctttatt     60

tcccttcttt ttctctttag ctcggcttat tccaggggtg tgtttcgtcg agatgcacac    120

aagagtgagg ttgctcatcg gtttaaagat ttgggagaag aaaatttcaa agccttggtg    180

ttgattgcct ttgctcagta tcttcagcag tgtccatttg aagatcatgt aaaattagtg    240

aatgaagtaa ctgaatttgc aaaaacatgt gttgctgatg agtcagctga aaattgtgac    300

aaatcacttc ataccctttt tggagacaaa ttatgcacag ttgcaactct tcgtgaaacc    360

tatggtgaaa tggctgactg ctgtgcaaaa caagaacctg agagaaatga atgcttcttg    420

caacacaaag atgacaaccc aaacctcccc cgattggtga gaccagaggt tgatgtgatg    480

tgcactgctt ttcatgacaa tgaagagaca tttttgaaaa aatacttata tgaaattgcc    540

agaagacatc cttactttta tgccccggaa ctccttttct ttgctaaaag gtataaagct    600

gcttttacag aatgttgcca agctgctgat aaagctgcct gcctgttgcc aaagctcgat    660

gaacttcggg atgaagggaa ggcttcgtct gccaaacaga gactcaagtg tgccagtctc    720

caaaaatttg gagaaagagc tttcaaagca tgggcagtag ctcgcctgag ccagagattt    780

cccaaagctg agtttgcaga agtttccaag ttagtgacag atcttaccaa agtccacacg    840

gaatgctgcc atggagatct gcttgaatgt gctgatgaca gggcggacct tgccaagtat    900

atctgtgaaa atcaagattc gatctccagt aaactgaagg aatgctgtga aaaacctctg    960

ttggaaaaat cccactgcat tgccgaagtg gaaaatgatg agatgcctgc tgacttgcct   1020

tcattagctg ctgattttgt tgaaagtaag gatgtttgca aaaactatgc tgaggcaaag   1080

gatgtcttcc tgggcatgtt tttgtatgaa tatgcaagaa ggcatcctga ttactctgtc   1140

gtgctgctgc tgagacttgc caagacatat gaaaccactc tagagaagtg ctgtgccgct   1200

gcagatcctc atgaatgcta tgccaaagtg ttcgatgaat ttaaacctct tgtggaagag   1260

cctcagaatt taatcaaaca aaattgtgag ctttttgagc agcttggaga gtacaaattc   1320

cagaatgcgc tattagttcg ttacaccaag aaagtacccc aagtgtcaac tccaactctt   1380

gtagaggtct caagaaacct aggaaaagtg ggcagcaaat gttgtaaaca tcctgaagca   1440

aaaagaatgc cctgtgcaga agactatcta tccgtggtcc tgaaccagtt atgtgtgttg   1500

catgagaaaa cgccagtaag tgacagagtc accaaatgct gcacagaatc cttggtgaac   1560

aggcgaccat gcttttcagc tctggaagtc gatgaaacat acgttcccaa agagtttaat   1620

gctgaaacat tcaccttcca tgcagatata tgcacacttt ctgagaagga gagacaaatc   1680

aagaaacaaa ctgcacttgt tgagctcgtg aaacacaagc ccaaggcaac aaaagagcaa   1740

ctgaaagctg ttatggatga tttcgcagct tttgtagaga agtgctgcaa ggctgacgat   1800

aaggagacct gctttgccga ggagggtaaa aaacttgttg ctgcaagtca agctgcctta   1860

ggcttataac atctacattt aaaagcatct cagcctacca tgagaataag agaaagaaaa   1920

tgaagatcaa aagcttattc atctgttttc tttttcgttg gtgtaaagcc aacaccctgt   1980

ctaaaaaaca taaatttctt taatcatttt gcctcttttc tctgtgcttc aattaataaa   2040

aaatggaaag aatctaatag agtggtacag cactgttatt tttcaaagat gtgttgctat   2100

cctgaaaatt ctgtaggttc tgtggaagtt ccagtgttct ctcttattcc acttcggtag   2160

aggatttcta gtttctgtgg gctaattaaa taaatcacta atactcttct aagtt        2215


<210>  264
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  265
<211>  2128
<212>  DNA
<213>  Homo sapiens

<400>  265
ctggaaacca ctgcaatgac attattccca gtgctgttgt tcctggttgc tgggctgctt     60

ccatcttttc cagcaaatga agataaggat cccgctttta ctgctttgtt aaccacccaa    120

acacaagtgc aaagggagat tgtgaataag cacaatgaac tgaggagagc agtatctccc    180

cctgccagaa acatgctgaa gatggaatgg aacaaagagg ctgcagcaaa tgcccaaaag    240

tgggcaaacc agtgcaatta cagacacagt aacccaaagg atcgaatgac aagtctaaaa    300

tgtggtgaga atctctacat gtcaagtgcc tccagctcat ggtcacaagc aatccaaagc    360

tggtttgatg agtacaatga ttttgacttt ggtgtagggc caaagactcc caacgcagtg    420

gttggacatt atacacaggt tgtttggtac tcttcatacc tcgttggatg tggaaatgcc    480

tactgtccca atcaaaaagt tctaaaatac tactatgttt gccaatattg tcctgctggt    540

aattgggcta atagactata tgtcccttat gaacaaggag caccttgtgc cagttgccca    600

gataactgtg acgatggact atgcaccaat ggttgcaagt acgaagatct ctatagtaac    660

tgtaaaagtt tgaagctcac attaacctgt aaacatcagt tggtcaggga cagttgcaag    720

gcctcctgca attgttcaaa cagcatttat taaatacgca ttacacaccg agtagggcta    780

tgtagagagg agtcagatta tctacttaga tttggcatct acttagattt aacatatact    840

agctgagaaa ttgtaggcat gtttgataca catttgattt caaatgtttt tcttctggat    900

ctgcttttta ttttacaaaa atatttttca tacaaatggt taaaaagaaa caaaatctat    960

aacaacaact ttggattttt atatataaac tttgtgattt aaatttactg aatttaatta   1020

gggtgaaaat tttgaaagtt gtattctcat atgactaagt tcactaaaac cctggattga   1080

aagtgaaaat tatgttccta gaacaaaatg tacaaaaaga acaatataat tttcacatga   1140

acccttggct gtagttgcct ttcctagctc cactctaagg ctaagcatct tcaaagacgt   1200

tttcccatat gctgtcttaa ttcttttcac tcattcaccc ttcttcccaa tcatctggct   1260

ggcatcctca caattgagtt gaagctgttc ctcctaaaac aatcctgact tttattttgc   1320

caaaatcaat acaatccttt gaatttttta tctgcataaa ttttacagta gaatatgatc   1380

aaaccttcat ttttaaacct ctcttctctt tgacaaaact tccttaaaaa agaatacaag   1440

ataatatagg taaataccct ccactcaagg aggtagaact cagtcctctc ccttgtgagt   1500

cttcactaaa atcagtgact cacttccaaa gagtggagta tggaaaggga aacatagtaa   1560

ctttacaggg gagaaaaatg acaaatgacg tcttcaccaa gtgatcaaaa ttaacgtcac   1620

cagtgataag tcattcagat ttgttctaga taatctttct aaaaattcat aatcccaatc   1680

taattatgag ctaaaacatc cagcaaactc aagttgaagg acattctaca aaatatccct   1740

ggggtatttt agagtattcc tcaaaactgt aaaaatcatg gaaaataagg gaatcctgag   1800

aaacaatcac agaccacatg agactaagga gacatgtgag ccaaatgcaa tgtgcttctt   1860

ggatcagatc ctggaacaga aaaagatcag taatgaaaaa actgatgaag tctgaataga   1920

atctggagta tttttaacag tagtgttgat ttcttaatct tgacaaatat agcagggtaa   1980

tgtaagatga taacgttaga gaaactgaaa ctgggtgagg gctatctagg aattctctgt   2040

actatcttac caaattttcg gtaagtctaa gaaagcaatg caaaataaaa agtgtcttga   2100

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                      2128


<210>  266
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  266

Met Thr Leu Phe Pro Val Leu Leu Phe Leu Val Ala Gly Leu Leu Pro 
1               5                   10                  15      


Ser Phe Pro Ala Asn Glu Asp Lys Asp Pro Ala Phe Thr Ala Leu Leu 
            20                  25                  30          


Thr Thr Gln Thr Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu 
        35                  40                  45              


Leu Arg Arg Ala Val Ser Pro Pro Ala Arg Asn Met Leu Lys Met Glu 
    50                  55                  60                  


Trp Asn Lys Glu Ala Ala Ala Asn Ala Gln Lys Trp Ala Asn Gln Cys 
65                  70                  75                  80  


Asn Tyr Arg His Ser Asn Pro Lys Asp Arg Met Thr Ser Leu Lys Cys 
                85                  90                  95      


Gly Glu Asn Leu Tyr Met Ser Ser Ala Ser Ser Ser Trp Ser Gln Ala 
            100                 105                 110         


Ile Gln Ser Trp Phe Asp Glu Tyr Asn Asp Phe Asp Phe Gly Val Gly 
        115                 120                 125             


Pro Lys Thr Pro Asn Ala Val Val Gly His Tyr Thr Gln Val Val Trp 
    130                 135                 140                 


Tyr Ser Ser Tyr Leu Val Gly Cys Gly Asn Ala Tyr Cys Pro Asn Gln 
145                 150                 155                 160 


Lys Val Leu Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn 
                165                 170                 175     


Trp Ala Asn Arg Leu Tyr Val Pro Tyr Glu Gln Gly Ala Pro Cys Ala 
            180                 185                 190         


Ser Cys Pro Asp Asn Cys Asp Asp Gly Leu Cys Thr Asn Gly Cys Lys 
        195                 200                 205             


Tyr Glu Asp Leu Tyr Ser Asn Cys Lys Ser Leu Lys Leu Thr Leu Thr 
    210                 215                 220                 


Cys Lys His Gln Leu Val Arg Asp Ser Cys Lys Ala Ser Cys Asn Cys 
225                 230                 235                 240 


Ser Asn Ser Ile Tyr 
                245 


<210>  267
<211>  5304
<212>  DNA
<213>  Homo sapiens

<400>  267
ggctgggctg cgaatagcgt gttcctctcc ggcggaacac acacacccgg ccttggggct     60

gtctcctgag ctccctcctc cacggagagc gctgagcgcc gccgggaatt ccatcccacc    120

gtgggcacgc agtctttgga ggtcccgggc gcagcacgct cggtgtcccc acactgcagc    180

aagacagaga ccccgcggga accttgagct tggaacaacc cttgagcctc tgcagtcgga    240

agagtgggcg cagcagccca gcggaggcca ggcgcgcaac ctcgggcgcc ggggcaagga    300

gagagtgcag ggaggcgcag ctcaggcgcc cggctcagga gcgggaggaa gttctcgcgg    360

cgccgggagc gcggtggacg cgccctgggc gcacgcccag gcagccttct ccctggccct    420

cgggactgtc ctcgggccgc aaggaggagc ttgctggagt cttagaggcc atccagagcc    480

agcgagcagg agcgctgcgt ctcccgcctc agctaggaag ggggagtggc gctggcaggc    540

tggagctggg aacccagcga gcgcctgacc ttcctcctcc tcttcctgac cctcttcgcg    600

tcttgggctc cggaggaagg ttctagcggc tgcaggaggt ccccagaccc attttcctag    660

aaggctggtg atggatctgc tgctcctgcc gccgccgggg cacttggagc gcaccggcgg    720

cgcgtgagct gggctttgct ctccactgcc ctgggcaaac cccgggccag ccccgcctgg    780

cacctttgcc tgagtccctt tcggttcccg acccaaagcc accagcgtcc agggagggag    840

gaggaggtgg tcctcaggtg cagccccgcc gagatgtccg cgcagagcct gctccacagc    900

gtcttctcct gttcctcgcc cgcttcaagt agcgcggcct cggccaaggg cttctccaag    960

aggaagctgc gccagacccg cagcctggac ccggccctga tcggcggctg cgggagcgac   1020

gaggcgggcg cggagggcag tgcgcgggga gccacggcgg gccgcctcta ctccccatca   1080

ctcccagccg agagtctcgg ccctcgcttg gcgtcctctt cccggggtcc gccccccagg   1140

gccaccaggc taccgcctcc tggacctctt tgctcgtcct tctccacacc cagcaccccg   1200

caggagaagt caccatccgg cagctttcac tttgactatg aggttcccct gggtcgcggc   1260

ggcctcaaga agagcatggc ctgggacctg ccttctgtcc tggccgggcc agccagtagc   1320

cgaagcgctt ccagcatcct ctgttcatcc gggggaggcc ccaatggcat cttcgcttct   1380

cctaggaggt ggctccagca gaggaagttc cagtccccac ccgacagtcg cgggcacccc   1440

tacgtcgtgt ggaaatccga gttggagttg tatgatcttc agatcttagg cacaaaacca   1500

ccgatgaatt ccgatacaca tcgtaacttt gaccccaccg caacccttag aaatcagggt   1560

gatttcacct ggaacagcat gtcaggccgc agtgtacggc tgaggtcagt ccccatccag   1620

agtctctcag agctggagag ggcccggctg caggaagtgg ctttttatca gttgcaacag   1680

gactgtgacc tgagctgtca gatcaccatt cccaaagatg gacaaaagag aaagaaatct   1740

ttaagaaaga aactggattc actaggaaag gagaaaaaca aagacaaaga attcatccca   1800

caggcatttg gaatgccctt atcccaagtc attgcgaatg acagggccta taaactcaag   1860

caggacttgc agagggacga gcagaaagat gcatctgact ttgtggcttc cctcctccca   1920

tttggaaata aaagacaaaa caaagaactc tcaagcagta actcatctct cagctcaacc   1980

tcagaaacac cgaatgagtc aacgtcccca aacaccccgg aaccggctcc tcgggctagg   2040

aggaggggtg ccatgtcagt ggattctatc accgatcttg atgacaatca gtctcgacta   2100

ctagaagctt tacaactttc cttgcctgct gaggctcaaa gtaaaaagga aaaagccaga   2160

gataagaaac tcagtctgaa tcctatttac agacaggtcc ctaggctggt ggacagctgc   2220

tgtcagcacc tagaaaaaca tggcctccag acagtgggga tattccgagt tggaagctca   2280

aaaaagagag tgagacaatt acgtgaggaa tttgaccgtg ggattgatgt ctctctggag   2340

gaggagcaca gtgttcatga tgtggcagcc ttgctgaaag agttcctgag ggacatgcca   2400

gacccccttc tcaccaggga gctgtacaca gctttcatca acactctctt gttggagccg   2460

gaggaacagc tgggcacctt gcagctcctc atataccttc tacctccctg caactgcgac   2520

accctccacc gcctgctaca gttcctctcc atcgtggcca ggcatgccga tgacaacatc   2580

agcaaagatg ggcaagaggt cactgggaat aaaatgacat ctctaaactt agccaccata   2640

tttggaccca acctgctgca caagcagaag tcatcagaca aagaattctc agttcagagt   2700

tcagcccggg ctgaggagag cacggccatc atcgctgttg tgcaaaagat gattgaaaat   2760

tatgaagccc tgttcatggt tcccccagat ctccagaacg aagtgctgat cagcctgtta   2820

gagaccgatc ctgatgtcgt ggactattta ctcagaagaa aggcttccca atcatcaaca   2880

agttctgtgc ttccggctgc agtgcaggcc tgcccacagt accctgccag catgtttacg   2940

ccctgacctg gagggaccag ctaaggaagc cctgacatgc tgcagtcgga agtttccttt   3000

tccgtgggag ggaggcattc atctacagac tccaacaagg cctccagcgg agacatctcc   3060

ccttatgaca acaactcccc agtgctgtct gagcgctccc tgctggctat gcaagaggac   3120

gcggccccgg ggggctcgga gaagctttac agagtgccag ggcagtttat gctggtgggc   3180

cacttgtcgt cgtcaaagtc aagggaaagt tctcctggac caaggcttgg gaaagatctg   3240

tcagaggagc ctttcgatat ctggggaact tggcattcaa cattaaaaag cggatccaaa   3300

gacccaggaa tgacaggttc ctctggagac atttttgaaa gcagctccct aagagcgggg   3360

ccctgctccc tttctcaagg gaacctgtcc ccaaattggc ctcggtggca ggggagcccc   3420

gcagagctgg acagcgacac gcagggggct cggaggactc aggccgcagc ccccgcgacg   3480

gagggcaggg cccaccctgc ggtgtcgcgc gcctgcagca cgccccacgt ccaggtggca   3540

gggaaagccg agcggcccac ggccaggtcg gagcagtact tgaccctgag cggcgcccac   3600

gacctcagcg agagtgagct ggatgtggcc gggctgcaga gccgggccac acctcagtgc   3660

caaagacccc atgggagtgg gagggatgac aagcggcccc cgcctccata cccgggccca   3720

gggaagcccg cggcagcggc agcctggatc caggggcccc cggaaggcgt ggagacaccc   3780

acggaccagg gaggccaagc agccgagcga gagcagcagg tcacgcagaa aaaactgagc   3840

agcgccaact ccctgccagc gggcgagcag gacagtccgc gcctggggga cgctggctgg   3900

ctcgactggc agagagagcg ctggcagatc tgggagctcc tgtcgaccga caaccccgat   3960

gccctgcccg agacgctggt ctgagcccgc acccagccga gccccccctg ccccgagccc   4020

cccgccctcc agcccagggg ggaccgtggg tggtggccac tggcacactt agtgttcttc   4080

tttcacactt ctcaaaagtg acacaagaga aatccagttc acctacagag gtagagcact   4140

cacgcccccg ccattgagaa taaggttcca ttgcgtagcc agccttagga aaaacaaaca   4200

gaacccaaac cagatggcaa tgtccaatct aaaaacgtcc ctcttggctc tataatataa   4260

gatacaactc ttgcttggta tagcctaacc gtatttatgt gtcttcggtt ttgactattg   4320

tgtattctgt aacagattat gtataatcat atatgatata ttcacaaaga gaaaacaaaa   4380

ggaactttta aaaaaaaaat cacttcactt atattaagca atgagatata ctaaacaatg   4440

agattctata gaatgttcta gaatgtgcac aagcgggttt ctgtgctttt gccatagctt   4500

tataactggg gataaccctt ccttcgatac caaacactaa caagaggaag cagaatatga   4560

gaagccatat ttttacatag gagtcagata caaaaagaaa aatcactgaa tgcttttaga   4620

tattgaatac gttttcagga aaatgctaaa tctgatagat tacgaaatat atttttagaa   4680

cttgtttaga aaggattcag ttaaccaaac aagaaaaagg cagtgcctca caaagaaatt   4740

aagaagttgt ccgtcccacg ttacatcaaa ttcagtttta tataggccat atataatata   4800

tatttataat gtataatttt tatgtatttt tcaaaactac aaactggaat ccaactataa   4860

agtgtttaag aatctacaca gaatattcaa attatagaac atgttttttc cctttgcccc   4920

ataatcagta tttgccaaat tacatgcaat tccttaaaaa ctaaatcaca tttggtaaaa   4980

ggcctacagc tttgtactta cattgtgcca aaggctgagg aaatgttttc tttcgtaatt   5040

ttatgtgtat tgtaaaatgt tctaccgtac tttagtagtt tgaagttttt caagtgcata   5100

actatttttg accagcagat ggcgatacgc ttcagtattt tatgcaattt tttttcactt   5160

ctgaagggaa agtgtattat aaaaaaagat tttttttttt tttataaaac atgctactct   5220

taattttcat gttggtgatg aaattcccag tggtgtttct taaggttcta tcttgtgcca   5280

tgatgaataa aaagttaagc aaag                                          5304


<210>  268
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Ser Ala Gln Ser Leu Leu His Ser Val Phe Ser Cys Ser Ser Pro 
1               5                   10                  15      


Ala Ser Ser Ser Ala Ala Ser Ala Lys Gly Phe Ser Lys Arg Lys Leu 
            20                  25                  30          


Arg Gln Thr Arg Ser Leu Asp Pro Ala Leu Ile Gly Gly Cys Gly Ser 
        35                  40                  45              


Asp Glu Ala Gly Ala Glu Gly Ser Ala Arg Gly Ala Thr Ala Gly Arg 
    50                  55                  60                  


Leu Tyr Ser Pro Ser Leu Pro Ala Glu Ser Leu Gly Pro Arg Leu Ala 
65                  70                  75                  80  


Ser Ser Ser Arg Gly Pro Pro Pro Arg Ala Thr Arg Leu Pro Pro Pro 
                85                  90                  95      


Gly Pro Leu Cys Ser Ser Phe Ser Thr Pro Ser Thr Pro Gln Glu Lys 
            100                 105                 110         


Ser Pro Ser Gly Ser Phe His Phe Asp Tyr Glu Val Pro Leu Gly Arg 
        115                 120                 125             


Gly Gly Leu Lys Lys Ser Met Ala Trp Asp Leu Pro Ser Val Leu Ala 
    130                 135                 140                 


Gly Pro Ala Ser Ser Arg Ser Ala Ser Ser Ile Leu Cys Ser Ser Gly 
145                 150                 155                 160 


Gly Gly Pro Asn Gly Ile Phe Ala Ser Pro Arg Arg Trp Leu Gln Gln 
                165                 170                 175     


Arg Lys Phe Gln Ser Pro Pro Asp Ser Arg Gly His Pro Tyr Val Val 
            180                 185                 190         


Trp Lys Ser Glu Leu Glu Leu Tyr Asp Leu Gln Ile Leu Gly Thr Lys 
        195                 200                 205             


Pro Pro Met Asn Ser Asp Thr His Arg Asn Phe Asp Pro Thr Ala Thr 
    210                 215                 220                 


Leu Arg Asn Gln Gly Asp Phe Thr Trp Asn Ser Met Ser Gly Arg Ser 
225                 230                 235                 240 


Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu Ser Glu Leu Glu Arg 
                245                 250                 255     


Ala Arg Leu Gln Glu Val Ala Phe Tyr Gln Leu Gln Gln Asp Cys Asp 
            260                 265                 270         


Leu Ser Cys Gln Ile Thr Ile Pro Lys Asp Gly Gln Lys Arg Lys Lys 
        275                 280                 285             


Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys Glu Lys Asn Lys Asp 
    290                 295                 300                 


Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro Leu Ser Gln Val Ile 
305                 310                 315                 320 


Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp Leu Gln Arg Asp Glu 
                325                 330                 335     


Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu Leu Pro Phe Gly Asn 
            340                 345                 350         


Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn Ser Ser Leu Ser Ser 
        355                 360                 365             


Thr Ser Glu Thr Pro Asn Glu Ser Thr Ser Pro Asn Thr Pro Glu Pro 
    370                 375                 380                 


Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser Val Asp Ser Ile Thr 
385                 390                 395                 400 


Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu Ala Leu Gln Leu Ser 
                405                 410                 415     


Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys Ala Arg Asp Lys Lys 
            420                 425                 430         


Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro Arg Leu Val Asp Ser 
        435                 440                 445             


Cys Cys Gln His Leu Glu Lys His Gly Leu Gln Thr Val Gly Ile Phe 
    450                 455                 460                 


Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln Leu Arg Glu Glu Phe 
465                 470                 475                 480 


Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu His Ser Val His Asp 
                485                 490                 495     


Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp Met Pro Asp Pro Leu 
            500                 505                 510         


Leu Thr Arg Glu Leu Tyr Thr Ala Phe Ile Asn Thr Leu Leu Leu Glu 
        515                 520                 525             


Pro Glu Glu Gln Leu Gly Thr Leu Gln Leu Leu Ile Tyr Leu Leu Pro 
    530                 535                 540                 


Pro Cys Asn Cys Asp Thr Leu His Arg Leu Leu Gln Phe Leu Ser Ile 
545                 550                 555                 560 


Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys Asp Gly Gln Glu Val 
                565                 570                 575     


Thr Gly Asn Lys Met Thr Ser Leu Asn Leu Ala Thr Ile Phe Gly Pro 
            580                 585                 590         


Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys Glu Phe Ser Val Gln 
        595                 600                 605             


Ser Ser Ala Arg Ala Glu Glu Ser Thr Ala Ile Ile Ala Val Val Gln 
    610                 615                 620                 


Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met Val Pro Pro Asp Leu 
625                 630                 635                 640 


Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Thr Asp Pro Asp Val Val 
                645                 650                 655     


Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser Ser Thr Ser Ser Val 
            660                 665                 670         


Leu Pro Ala Ala Val Gln Ala Cys Pro Gln Tyr Pro Ala Ser Met Phe 
        675                 680                 685             


Thr Pro 
    690 


<210>  269
<211>  3084
<212>  DNA
<213>  Homo sapiens

<400>  269
aagatctaaa aacggacatc tccaccgtgg gtggctcctt tttctttttc tttttttccc     60

acccttcagg aagtggacgt ttcgttatct tctgatcctt gcaccttctt ttggggaaac    120

ggggcccttc tgcccagatc ccctctcttt tctcggaaaa caaactacta agtcggcatc    180

cggggtaact acagtggaga gggtttccgc ggagacgcgc cgccggaccc tcctctgcac    240

tttggggagg cgtgctccct ccagaaccgg cgttctccgc gcgcaaatcc cggcgacgcg    300

gggtcgcggg gtggccgccg gggcagcctc gtctagcgcg cgccgcgcag acgcccccgg    360

agtcgccagc taccgcagcc ctcgccgccc agtgcccttc ggcctcgggg cgggcgcctg    420

cgtcggtctc cgcgaagcgg gaaagcgcgg cggccgccgg gattcgggcg ccgcggcagc    480

tgctccggct gccggccggc ggccccgcgc tcgcccgccc cgcttccgcc cgctgtcctg    540

ctgcacgaac ccttccaact ctcctttcct cccccaccct tgagttaccc ctctgtcttt    600

cctgctgttg cgcgggtgct cccacagcgg agcggagatt acagagccgc cgggatgccc    660

caactctccg gaggaggtgg cggcggcggg ggggacccgg aactctgcgc cacggacgag    720

atgatcccct tcaaggacga gggcgatcct cagaaggaaa agatcttcgc cgagatcagt    780

catcccgaag aggaaggcga tttagctgac atcaagtctt ccttggtgaa cgagtctgaa    840

atcatcccgg ccagcaacgg acacgaggtg gccagacaag cacaaacctc tcaggagccc    900

taccacgaca aggccagaga acaccccgat gacggaaagc atccagatgg aggcctctac    960

aacaagggac cctcctactc gagttattcc gggtacataa tgatgccaaa tatgaataac   1020

gacccataca tgtcaaatgg atctctttct ccacccatcc cgagaacatc aaataaagtg   1080

cccgtggtgc agccatccca tgcggtccat cctctcaccc ccctcatcac ttacagtgac   1140

gagcactttt ctccaggatc acacccgtca cacatcccat cagatgtcaa ctccaaacaa   1200

ggcatgtcca gacatcctcc agctcctgat atccctactt tttatccctt gtctccgggt   1260

ggtgttggac agatcacccc acctcttggc tggcaaggtc agcctgtata tcccatcacg   1320

ggtggattca ggcaacccta cccatcctca ctgtcagtcg acacttccat gtccaggttt   1380

tcccatcata tgattcccgg tcctcctggt ccccacacaa ctggcatccc tcatccagct   1440

attgtaacac ctcaggtcaa acaggaacat ccccacactg acagtgacct aatgcacgtg   1500

aagcctcagc atgaacagag aaaggagcag gagccaaaaa gacctcacat taagaagcct   1560

ctgaatgctt ttatgttata catgaaagaa atgagagcga atgtcgttgc tgagtgtact   1620

ctaaaagaaa gtgcagctat caaccagatt cttggcagaa ggtggcatgc cctctcccgt   1680

gaagagcagg ctaaatatta tgaattagca cggaaagaaa gacagctaca tatgcagctt   1740

tatccaggct ggtctgcaag agacaattat ggtaagaaaa agaagaggaa gagagagaaa   1800

ctacaggaat ctgcatcagg tacaggtcca agaatgacag ctgcctacat ctgaaacatg   1860

gtggaaaacg aagctcattc ccaacgtgca aagccaaggc agcgacccca ggacctcttc   1920

tggagatgga agcttgttga aaacccagac tgtctccacg gcctgcccag tcgacgccaa   1980

aggaacactg acatcaattt taccctgagg tcactgctag agacgctgat ccataaagac   2040

aatcactgcc aacccctctt tcgtctactg caagagccaa gttccaaaat aaagcataaa   2100

aaggtttttt aaaaggaaat gtaaaagcac atgagaatgc tagcaggctg tggggcagct   2160

gagcagcttt tctcccccca tatctgcgtg cacttcccag agcatcttgc atccaaacct   2220

gtaacctttc ggcaaggacg gtaacttggc tgcatttgcc tgtcatgcgc aactggagcc   2280

agcaaccagc tatccatcag caccccagtg gaggagttca tggaagagtt ccctctttgt   2340

ttctgcttca tttttctttc ttttcttttc tcctaaagct tttatttaac agtgcaaaag   2400

gatcgttttt ttttgctttt ttaaacttga atttttttaa tttacacttt ttagttttaa   2460

ttttcttgta tattttgcta gctatgagct tttaaataaa attgaaagtt ctggaaaagt   2520

ttgaaataat gacataaaaa gaagccttct ttttctgaga cagcttgtct ggtaagtggc   2580

ttctctgtga attgcctgta acacatagtg gcttctccgc ccttgtaagg tgttcagtag   2640

agctaaataa atgtaatagc caaaccccac tctgttggta gcaattggca gccctatttc   2700

agtttatttt ttcttctgtt ttcttctttt ctttttttaa acagtaaacc ttaacagatg   2760

cgttcagcag actggtttgc agtgaatttt catttctttc cttatcaccc ccttgttgta   2820

aaaagcccag cacttgaatt gttattactt taaatgttct gtatttgtat ctgtttttat   2880

tagccaatta gtgggatttt atgccagttg ttaaaatgag cattgatgta cccatttttt   2940

aaaaaagcaa gcacagcctt tgcccaaaac tgtcatccta acgtttgtca ttccagtttg   3000

agttaatgtg ctgagcattt ttttaaaaga agctttgtaa taaaacattt ttaaaaattg   3060

tcatttaaaa aaaaaaaaaa aaaa                                          3084


<210>  270
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Pro Gln Leu Ser Gly Gly Gly Gly Gly Gly Gly Gly Asp Pro Glu 
1               5                   10                  15      


Leu Cys Ala Thr Asp Glu Met Ile Pro Phe Lys Asp Glu Gly Asp Pro 
            20                  25                  30          


Gln Lys Glu Lys Ile Phe Ala Glu Ile Ser His Pro Glu Glu Glu Gly 
        35                  40                  45              


Asp Leu Ala Asp Ile Lys Ser Ser Leu Val Asn Glu Ser Glu Ile Ile 
    50                  55                  60                  


Pro Ala Ser Asn Gly His Glu Val Ala Arg Gln Ala Gln Thr Ser Gln 
65                  70                  75                  80  


Glu Pro Tyr His Asp Lys Ala Arg Glu His Pro Asp Asp Gly Lys His 
                85                  90                  95      


Pro Asp Gly Gly Leu Tyr Asn Lys Gly Pro Ser Tyr Ser Ser Tyr Ser 
            100                 105                 110         


Gly Tyr Ile Met Met Pro Asn Met Asn Asn Asp Pro Tyr Met Ser Asn 
        115                 120                 125             


Gly Ser Leu Ser Pro Pro Ile Pro Arg Thr Ser Asn Lys Val Pro Val 
    130                 135                 140                 


Val Gln Pro Ser His Ala Val His Pro Leu Thr Pro Leu Ile Thr Tyr 
145                 150                 155                 160 


Ser Asp Glu His Phe Ser Pro Gly Ser His Pro Ser His Ile Pro Ser 
                165                 170                 175     


Asp Val Asn Ser Lys Gln Gly Met Ser Arg His Pro Pro Ala Pro Asp 
            180                 185                 190         


Ile Pro Thr Phe Tyr Pro Leu Ser Pro Gly Gly Val Gly Gln Ile Thr 
        195                 200                 205             


Pro Pro Leu Gly Trp Gln Gly Gln Pro Val Tyr Pro Ile Thr Gly Gly 
    210                 215                 220                 


Phe Arg Gln Pro Tyr Pro Ser Ser Leu Ser Val Asp Thr Ser Met Ser 
225                 230                 235                 240 


Arg Phe Ser His His Met Ile Pro Gly Pro Pro Gly Pro His Thr Thr 
                245                 250                 255     


Gly Ile Pro His Pro Ala Ile Val Thr Pro Gln Val Lys Gln Glu His 
            260                 265                 270         


Pro His Thr Asp Ser Asp Leu Met His Val Lys Pro Gln His Glu Gln 
        275                 280                 285             


Arg Lys Glu Gln Glu Pro Lys Arg Pro His Ile Lys Lys Pro Leu Asn 
    290                 295                 300                 


Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Asn Val Val Ala Glu 
305                 310                 315                 320 


Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg 
                325                 330                 335     


Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala 
            340                 345                 350         


Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala 
        355                 360                 365             


Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Glu Lys Leu Gln 
    370                 375                 380                 


Glu Ser Ala Ser Gly Thr Gly Pro Arg Met Thr Ala Ala Tyr Ile 
385                 390                 395                 


<210>  271
<211>  4685
<212>  DNA
<213>  Homo sapiens

<400>  271
gggagcgcgg ggagcgcggg ccggcggcgg cgagggagga cgggggcgca gacggccggc     60

gcgcggcgcg gctaccatgg gcgtgcggtg agcagccgct cgggacgact tcctcggctg    120

cgcggcgctc gcgcggagct ccccggccgg cggtgcgtcc ccacggtcac catgaaagac    180

gacttcgcag aggaggagga ggtgcaatcc ttcggttaca agcggtttgg tattcaggaa    240

ggaacacaat gtaccaaatg taaaaataac tgggcactga agttttctat catattatta    300

tacattttgt gtgccttgct aacaatcaca gtagccattt tgggatataa agttgtagag    360

aaaatggaca atgtcacagg tggcatggaa acatctcgcc aaacctatga tgacaagctc    420

acagcagtgg aaagtgacct gaaaaaatta ggtgaccaaa ctgggaagaa agctatcagc    480

accaactcag aactctccac cttcagatca gacattctag atctccgtca gcaacttcgt    540

gagattacag aaaaaaccag caagaacaag gatacgctgg agaagttaca ggcgagcggg    600

gatgctctgg tggacaggca gagtcaattg aaagaaactt tggagaataa ctctttcctc    660

atcaccactg taaacaaaac cctccaggcg tataatggct atgtcacgaa tctgcagcaa    720

gataccagcg tgctccaggg caatctgcag aaccaaatgt attctcataa tgtggtcatc    780

atgaacctca acaacctgaa cctgacccag gtgcagcaga ggaacctcat cacgaatctg    840

cagcggtctg tggatgacac aagccaggct atccagcgaa tcaagaacga ctttcaaaat    900

ctgcagcagg tttttcttca agccaagaag gacacggatt ggctgaagga gaaagtgcag    960

agcttgcaga cactggctgc caacaactct gcgttggcca aagccaacaa cgacaccctg   1020

gaggatatga acagccagct caactcattc acaggtcaga tggagaacat caccactatc   1080

tctcaagcca acgagcagaa cctgaaagac ctgcaggact tacacaaaga tgcagagaat   1140

agaacagcca tcaagttcaa ccaactggag gaacgcttcc agctctttga gacggatatt   1200

gtgaacatca ttagcaatat cagttacaca gcccaccacc tgcggacgct gaccagcaat   1260

ctaaatgaag tcaggaccac ttgcacagat acccttacca aacacacaga tgatctgacc   1320

tccttgaata ataccctggc caacatccgt ttggattctg tttctctcag gatgcaacaa   1380

gatttgatga ggtcgaggtt agacactgaa gtagccaact tatcagtgat tatggaagaa   1440

atgaagctag tagactccaa gcatggtcag ctcatcaaga attttacaat actacaaggt   1500

ccaccgggcc ccaggggtcc aagaggtgac agaggatccc agggaccccc tggcccaact   1560

ggcaacaagg gacagaaagg agagaagggg gagcctggac cacctggccc tgcgggtgag   1620

agaggcccaa ttggaccagc tggtcccccc ggagagcgtg gcggcaaagg atctaaaggc   1680

tcccagggcc ccaaaggctc ccgtggttcc cctgggaagc ccggccctca gggccccagt   1740

ggggacccag gccccccggg cccaccaggc aaagagggac tccccggccc tcagggccct   1800

cctggcttcc agggacttca gggcaccgtt ggggagcctg gggtgcctgg acctcgggga   1860

ctgccaggct tgcctggggt accaggcatg ccaggcccca agggcccccc cggccctcct   1920

ggcccatcag gagcggtggt gcccctggcc ctgcagaatg agccaacccc ggcaccggag   1980

gacaatagta agtccaagcc ctccctccag ccagggggac agggcagtgc atgtgcttga   2040

gactgagcca acccccagtg tgtggcccca cccatgttat ttttgttttt gtttttgttt   2100

tgagacaggg tctcactctg ttgcccaggc tggagtgcag tggcgtgatc tcggctcact   2160

gcaaccccca catcccgggt tcaagtgatt ctcctgcctt agcctcccag gtagctggga   2220

atacaagcgt gtgcccccac agccagctaa tttttgtatt tttagtagag aggggtttca   2280

cagtgttggg cagggtggtt tcaaacttct ggcctcaagt gatccaccta cctagtttcc   2340

caaagtgctg ggaatacagg tgtgaaccac cacgttttgt cccccggctg catattattt   2400

aacagcaaag gcatcatagg ggttggcaca ggagccctgc tgccagaaca ggcctccata   2460

ccaggcatgt gtctctctct aaacgccatt gggtttttta gtgctcattt gttttatgta   2520

ttatgtgtgt atgtatggga cagggtctca ctctgtcacc caggctggaa tgacgaagtg   2580

aagtagtgca aacatagctc attgcagctt tgacctcctg ggcttaggtg atcttcccac   2640

tcagactcct gcgtagctgg gaccacaggg gtatgccacc acacctggct aattttttat   2700

tttccttttt gtagaaacag ggtcttgcta tgttgcccag gctggtcttg aactcctggc   2760

ctcaagcaac cctcctgcct cagtcttgca aagtgctggg attccaggtg ggagccactg   2820

cacctggctc ttgcacttgt ttatttatag gagccagccc tcagaagaca aacacaatgc   2880

aaaacatttc cttcagggaa gcctgctggc cgccctgagc gctcttccct cgttttacat   2940

cctcactctg gagatagatg ggctccctcg gttagctcca tcaacatgtg gatggaaccc   3000

tctgctattg atgactacat ttaatttctt tttgagaaag gtgttagatg ttacggtgcc   3060

ttctagtctt ttgataatta aacctttggc aaaactcgaa tgtttggtta gcaaccaagc   3120

ctatttttct ctcctttgac ccaaccgcta ttctacttga ttttggtcgg tgaggcccgg   3180

gttatttttg ttgatccgtg agcccatttt tggtgctggg ttctcacatc caagtgttcc   3240

tgggttccgt atgattccag actgacgctg aacatctgtg cctgccctgc ttcttgttgt   3300

tgcttctgtc atttctgtca ttgtgaagac ggatccaaac acagaagaac aaagacccag   3360

tccaagatcc atccagatta tgtggtttcg gcttgtgctc tgcagtccac tttgggtcat   3420

gcttgctgcg agcacgtccg tgaacgtcag ctgtgggcct cgtgcaggga cgctcaggct   3480

gctcccagcg ggaccacagt tttggcctct gaaacacagc tgaagaaagg cagagtgctt   3540

tctgtgatct tttaatcaat gttttccact tttgcattcc taggctgccc gcctcactgg   3600

aagaacttca cagacaaatg ctactatttt tcagttgaga aagaaatttt tgaggatgca   3660

aagcttttct gtgaagacaa gtcttcacat cttgttttca taaacactag agaggaacag   3720

caatggataa aaaaacagat ggtagggaga gagagccact ggatcggcct cacagactca   3780

gagcgtgaaa atgaatggaa gtggctggat gggacatctc cagactacaa aaattggaaa   3840

gctggacagc cggataactg gggtcatggc catgggccag gagaagactg tgctgggttg   3900

atttatgctg ggcagtggaa cgatttccaa tgtgaagacg tcaataactt catttgcgaa   3960

aaagacaggg agacagtact gtcatctgca ttataacgga ctgtgatggg atcacatgag   4020

caaattttca gctctcaaag gcaaaggaca ctcctttcta attgcatcac cttctcatca   4080

gattgaaaaa aaaaaagcac tgaaaaccaa ttactgaaaa aaaattgaca gctagtgttt   4140

tttaccatcc gtcattaccc aaagacttgg gaactaaaat gttccccagg gtgatatgct   4200

gattttcatt gtgcacatgg actgaatcac atagattctc ctccgtcagt aaccgtgcga   4260

ttatacaaat tatgtcttcc aaagtatgga acactccaat cagaaaaagg ttatcattgg   4320

tcgttgagtt atgggaagaa cttaagcata tactgtgtaa acagtgccat acatttctaa   4380

aatcccaagt gtaggaaaaa tatgcagaca tacagatata taggccaact attagtaata   4440

atatgaaata tacttaaaga gcttttaaaa ctttgtattt ttgtacaaaa tatttgtctt   4500

ttacaatttt tttccttttt ttttttttgt cattttaccg acataataca tggagccaaa   4560

gaaaacaata atggtactaa taaaaactcc tagggtttcc tgtcagattt aattctaccc   4620

agtggcaaag aattttttca attgtggctt taaaaaaata attaaatata catgtatata   4680

tatat                                                               4685


<210>  272
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Pro Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Ser Lys Ser 
        595                 600                 605             


Lys Pro Ser Leu Gln Pro Gly Gly Gln Gly Ser Ala Cys Ala 
    610                 615                 620         


<210>  273
<211>  2560
<212>  DNA
<213>  Homo sapiens

<400>  273
ctcaaaaggg gccggatttc cttctcctgg aggcagatgt tgcctctctc tctcgctcgg     60

attggttcag tgcactctag aaacactgct gtggtggaga aactggaccc caggtctgga    120

gcgaattcca gcctgcaggg ctgataagcg aggcattagt gagattgaga gagactttac    180

cccgccgtgg tggttggagg gcgcgcagta gagcagcagc acaggcgcgg gtcccgggag    240

gccggctctg ctcgcgccga gatgtggaat ctccttcacg aaaccgactc ggctgtggcc    300

accgcgcgcc gcccgcgctg gctgtgcgct ggggcgctgg tgctggcggg tggcttcttt    360

ctcctcggct tcctcttcgg gtggtttata aaatcctcca atgaagctac taacattact    420

ccaaagcata atatgaaagc atttttggat gaattgaaag ctgagaacat caagaagttc    480

ttatataatt ttacacagat accacattta gcaggaacag aacaaaactt tcagcttgca    540

aagcaaattc aatcccagtg gaaagaattt ggcctggatt ctgttgagct agcacattat    600

gatgtcctgt tgtcctaccc aaataagact catcccaact acatctcaat aattaatgaa    660

gatggaaatg agattttcaa cacatcatta tttgaaccac ctcctccagg atatgaaaat    720

gtttcggata ttgtaccacc tttcagtgct ttctctcctc aaggaatgcc agagggcgat    780

ctagtgtatg ttaactatgc acgaactgaa gacttcttta aattggaacg ggacatgaaa    840

atcaattgct ctgggaaaat tgtaattgcc agatatggga aagttttcag aggaaataag    900

gttaaaaatg cccagctggc aggggccaaa ggagtcattc tctactccga ccctgctgac    960

tactttgctc ctggggtgaa gtcctatcca gatggttgga atcttcctgg aggtggtgtc   1020

cagcgtggaa atatcctaaa tctgaatggt gcaggagacc ctctcacacc aggttaccca   1080

gcaaatgaat atgcttatag gcgtggaatt gcagaggctg ttggtcttcc aagtattcct   1140

gttcatccaa ttggatacta tgatgcacag aagctcctag aaaaaatggg tggctcagca   1200

ccaccagata gcagctggag aggaagtctc aaagtgccct acaatgttgg acctggcttt   1260

actggaaact tttctacaca aaaagtcaag atgcacatcc actctaccaa tgaagtgaca   1320

agaatttaca atgtgatagg tactctcaga ggagcagtgg aaccagacag atatgtcatt   1380

ctgggaggtc accgggactc atgggtgttt ggtggtattg accctcagag tggagcagct   1440

gttgttcatg aaattgtgag gagctttgga acactgaaaa aggaagggtg gagacctaga   1500

agaacaattt tgtttgcaag ctgggatgca gaagaatttg gtcttcttgg ttctactgag   1560

tgggcagagg agaattcaag actccttcaa gagcgtggcg tggcttatat taatgctgac   1620

tcatctatag aaggaaacta cactctgaga gttgattgta caccgctgat gtacagcttg   1680

gtacacaacc taacaaaaga gctgaaaagc cctgatgaag gctttgaagg caaatctctt   1740

tatgaaagtt ggactaaaaa aagtccttcc ccagagttca gtggcatgcc caggataagc   1800

aaattgggat ctggaaatga ttttgaggtg ttcttccaac gacttggaat tgcttcaggc   1860

agagcacggt atactaaaaa ttgggaaaca aacaaattca gcggctatcc actgtatcac   1920

agtgtctatg aaacatatga gttggtggaa aagttttatg atccaatgtt taaatatcac   1980

ctcactgtgg cccaggttcg aggagggatg gtgtttgagc tagccaattc catagtgctc   2040

ccttttgatt gtcgagatta tgctgtagtt ttaagaaagt atgctgacaa aatctacagt   2100

atttctatga aacatccaca ggaaatgaag acatacagtg tatcatttga ttcacttttt   2160

tctgcagtaa agaattttac agaaattgct tccaagttca gtgagagact ccaggacttt   2220

gacaaaagca agcatgtcat ctatgctcca agcagccaca acaagtatgc aggggagtca   2280

ttcccaggaa tttatgatgc tctgtttgat attgaaagca aagtggaccc ttccaaggcc   2340

tggggagaag tgaagagaca gatttatgtt gcagccttca cagtgcaggc agctgcagag   2400

actttgagtg aagtagccta agaggattct ttagagaatc cgtattgaat ttgtgtggta   2460

tgtcactcag aaagaatcgt aatgggtata ttgataaatt ttaaaattgg tatatttgaa   2520

ataaagttga atattatata taaaaaaaaa aaaaaaaaaa                         2560


<210>  274
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  274

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Lys His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu 
            660                 665                 670         


Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val 
        675                 680                 685             


Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala 
    690                 695                 700                 


Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
705                 710                 715                 


<210>  275
<211>  551
<212>  DNA
<213>  Homo sapiens

<400>  275
accccatccg ctggctctca cccctcggag acgctcgccc gacagcatag tacttgccgc     60

ccagccacgc ccgcgcgcca gccaccatgc taggtaacaa gcgactgggg ctgtccggac    120

tgaccctcgc cctgtccctg ctcgtgtgcc tgggtgcgct ggccgaggcg tacccctcca    180

agccggacaa cccgggcgag gacgcaccag cggaggacat ggccagatac tactcggcgc    240

tgcgacacta catcaacctc atcaccaggc agagatatgg aaaacgatcc agcccagaga    300

cactgatttc agacctcttg atgagagaaa gcacagaaaa tgttcccaga actcggcttg    360

aagaccctgc aatgtggtga tgggaaatga gacttgctct ctggcctttt cctattttca    420

gcccatattt catcgtgtaa aacgagaatc cacccatcct accaatgcat gcagccactg    480

tgctgaattc tgcaatgttt tcctttgtca tcattgtata tatgtgtgtt taaataaagt    540

atcatgcatt c                                                         551


<210>  276
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Leu Gly Asn Lys Arg Leu Gly Leu Ser Gly Leu Thr Leu Ala Leu 
1               5                   10                  15      


Ser Leu Leu Val Cys Leu Gly Ala Leu Ala Glu Ala Tyr Pro Ser Lys 
            20                  25                  30          


Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp Met Ala Arg Tyr 
        35                  40                  45              


Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr Arg Gln Arg Tyr 
    50                  55                  60                  


Gly Lys Arg Ser Ser Pro Glu Thr Leu Ile Ser Asp Leu Leu Met Arg 
65                  70                  75                  80  


Glu Ser Thr Glu Asn Val Pro Arg Thr Arg Leu Glu Asp Pro Ala Met 
                85                  90                  95      


Trp 
    


<210>  277
<211>  1907
<212>  DNA
<213>  Homo sapiens

<400>  277
agcaaaaacc tcctggcaaa ggaggagagg aggttgtgcg ggacaacctt ctcctgacag     60

aaggatgtcg ctgctgagcc tgtcttggct gggcctcagg ccggtggcag catccccgtg    120

gctgctcctg ctggtggtcg gggcctcctg gctcctggcc cgcatcctgg cctggaccta    180

tgccttctat cacaacggcc gccgcctccg gtgtttcccg cagccccgga aacagaactg    240

gttcttgggt cacctgggcc tggtcactcc cacagaggag ggcttgaggg tcctgaccca    300

gctggtggcc acctaccccc agggctttgt gaggtggttg ggccccatca ctcccatcat    360

caacttgtgc caccctgaca tcgtccgatc tgtcatcaat acctcagatg ccattacaga    420

caaggacata gtcttctaca agaccctgaa gccctggctg ggggatgggc tcttgttaag    480

tgttggtgac aagtggagac accaccgtcg cttgctgacg cctgccttcc atttcaacat    540

cctgaagccc tatataaaga ttttcagcaa gagtgcaaac atcatgcatg ccaagtggca    600

acgcctggcc atggagggca gcacctgtct ggatgtgttt gagcacatca gccttatgac    660

cctggacagt ctgcagaaat gcatcttcag ctttgacagc aattgtcagg agaagcccag    720

tgaatatatt actgcgatca tggagctcag tgcccttgta gtgaaacgga ataaccagtt    780

cttccggtac aaggacttcc tgtacttcct cactccctgt ggacggcgct tccacagggc    840

ctgcagactg gtgcacgact tcacagatgc cgtcatccag gagcggcgcc gcaccctcac    900

tagccagggt gttgatgact tcctccaagc caaggccaag tccaagactt tggactttat    960

tgatgtgctc ctgctgagcg aggataaaaa tggtaaagag ttgtcagatg aggacataag   1020

agcagaagct gacactttca tgtttggagg ccatgacacc acggccagtg gcctctcctg   1080

ggtcttgtac aacctcgcga ggcacccaga ataccaagaa cgctgccggc aggaggtgca   1140

agagcttctg aaggaccgtg agcctaaaga gattgaatgg gacgacctgg cccagttgcc   1200

cttcctgacc atgtgcctga aggagagcct gcggttgcat cccccaatcc ctacattcgc   1260

ccgcggctgc acccaggacg tggtgctccc agacagccga gtcatcccca aagggaatgt   1320

ctgtaacatc aacatcttcg caatccatca caacccctca gtctggccag accctgaggt   1380

ctatgacccc ttccgcttcg acccagaaaa cgcccagaag aggtcaccta tggcttttat   1440

tcctttctcg gcggggccca ggaactgcat cgggcagaag ttcgcgatgg cagagatgaa   1500

ggtggtcctg gcgctcacgc tgctgcgctt ccgcatcctg cccgaccaca gggagccacg   1560

caggacgccg gagattgttt tgcgtgcgga ggacggactt tggctgcgag tagaacccct   1620

gggctgaggc ctgcagtgac ccacccacct acctttgcat cacctacctt tgcaccaact   1680

accttttcag atttccggta ataaatctgt gttggcccct gtgcctcagt cccgcggatg   1740

gccagtaggg ggcgctggag gactgcgggg atctagggcc tggctgggaa gaggcgggga   1800

gatgtctctg tgcccaagat actcactgcc tctctgggtg agcacaggag ccccgtgctg   1860

agggtgggat ctcccagagt ctaagtaaag actttttccc ccccaaa                 1907


<210>  278
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Ser Leu Leu Ser Leu Ser Trp Leu Gly Leu Arg Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Val Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Ala Phe Tyr His Asn Gly Arg Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Arg Lys Gln Asn Trp Phe Leu Gly His Leu 
    50                  55                  60                  


Gly Leu Val Thr Pro Thr Glu Glu Gly Leu Arg Val Leu Thr Gln Leu 
65                  70                  75                  80  


Val Ala Thr Tyr Pro Gln Gly Phe Val Arg Trp Leu Gly Pro Ile Thr 
                85                  90                  95      


Pro Ile Ile Asn Leu Cys His Pro Asp Ile Val Arg Ser Val Ile Asn 
            100                 105                 110         


Thr Ser Asp Ala Ile Thr Asp Lys Asp Ile Val Phe Tyr Lys Thr Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Val Gly Asp Lys Trp 
    130                 135                 140                 


Arg His His Arg Arg Leu Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Ile Lys Ile Phe Ser Lys Ser Ala Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Arg Leu Ala Met Glu Gly Ser Thr Cys Leu Asp Val Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Ile Phe 
        195                 200                 205             


Ser Phe Asp Ser Asn Cys Gln Glu Lys Pro Ser Glu Tyr Ile Thr Ala 
    210                 215                 220                 


Ile Met Glu Leu Ser Ala Leu Val Val Lys Arg Asn Asn Gln Phe Phe 
225                 230                 235                 240 


Arg Tyr Lys Asp Phe Leu Tyr Phe Leu Thr Pro Cys Gly Arg Arg Phe 
                245                 250                 255     


His Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Thr Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Glu Asp Lys Asn Gly Lys Glu Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Gly Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr Asn Leu Ala Arg His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Leu Lys Glu Ser Leu Arg Leu His Pro Pro Ile Pro Thr Phe Ala Arg 
385                 390                 395                 400 


Gly Cys Thr Gln Asp Val Val Leu Pro Asp Ser Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Asn Val Cys Asn Ile Asn Ile Phe Ala Ile His His Asn Pro Ser 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ala Gln Lys Arg Ser Pro Met Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Lys Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu Arg Phe Arg Ile Leu Pro Asp His Arg 
                485                 490                 495     


Glu Pro Arg Arg Thr Pro Glu Ile Val Leu Arg Ala Glu Asp Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Gly 
        515                 520 


<210>  279
<211>  2673
<212>  DNA
<213>  Homo sapiens

<400>  279
gtgccgcgcc cagagcagca gcaacagcga agatgcgagg ccattacctg tttgatccct     60

gtcggaaacc tggcacgggc caacttttcc cgattatcac gccaagaagt tgcaaggact    120

agtcgaagac tcggaggggc cagggcgagg gcgcgctccc ccgcgcgctg cctcctccct    180

cctccctccg gccgcccgag ctcccggcct ctctcccgcc cgcgctcact ccctccgccc    240

gcctccctcc tctggccccc tccgcgcggc acagggcggg gggtgccgcg aaactccgac    300

ccgagccact tggacttgca cagtgtccgc cgggcgcagg ggccgaccgc acgcagtcgc    360

gcagttctgc ctccgcctgc cagtctcgcc cgcgatcccg gcccggggct gtggcgtcga    420

ctccgaccca ggcagccagc agcccgcgcg ggagccggac cgccgccgga ggagctcgga    480

cggcatgctg agccccctcc ttggctgaag cccgagtgcg gagaagcccg ggcaaacgca    540

ggctaaggag accaaagcgg cgaagtcgcg agacagcgga caagcagcgg aggagaagga    600

ggaggaggcg aacccagaga ggggcagcaa aagaagcggt ggtggtgggc gtcgtggcca    660

tggcggcggc tatcgccagc tcgctcatcc gtcagaagag gcaagcccgc gagcgcgaga    720

aatccaacgc ctgcaagtgt gtcagcagcc ccagcaaagg caagaccagc tgcgacaaaa    780

acaagttaaa tgtcttttcc cgggtcaaac tcttcggctc caagaagagg cgcagaagaa    840

gaccagagcc tcagcttaag ggtatagtta ccaagctata cagccgacaa ggctaccact    900

tgcagctgca ggcggatgga accattgatg gcaccaaaga tgaggacagc acttacactc    960

tgtttaacct catccctgtg ggtctgcgag tggtggctat ccaaggagtt caaaccaagc   1020

tgtacttggc aatgaacagt gagggatact tgtacacctc ggaacttttc acacctgagt   1080

gcaaattcaa agaatcagtg tttgaaaatt attatgtgac atattcatca atgatatacc   1140

gtcagcagca gtcaggccga gggtggtatc tgggtctgaa caaagaagga gagatcatga   1200

aaggcaacca tgtgaagaag aacaagcctg cagctcattt tctgcctaaa ccactgaaag   1260

tggccatgta caaggagcca tcactgcacg atctcacgga gttctcccga tctggaagcg   1320

ggaccccaac caagagcaga agtgtctctg gcgtgctgaa cggaggcaaa tccatgagcc   1380

acaatgaatc aacgtagcca gtgagggcaa aagaagggct ctgtaacaga accttacctc   1440

caggtgctgt tgaattcttc tagcagtcct tcacccaaaa gttcaaattt gtcagtgaca   1500

tttaccaaac aaacaggcag agttcactat tctatctgcc attagacctt cttatcatcc   1560

atactaaagc cccattattt agattgagct tgtgcataag aatgccaagc attttagtga   1620

actaaatctg agagaaggac tgccaaattt tctcatgatc tcacctatga ctttggggat   1680

gataatccaa aagtatttca cagcactaat gctgatcaaa atttgctctc ccaccaagaa   1740

aatgtaaaag accacaattg ttcttcaaaa acaaacaaaa caaaacaaaa caaaattaac   1800

tgcttaaatg ttttgtcggg gcaaacaaaa ttatgtgaat tgtgttgttt tcttggcttg   1860

atgttttcta tctacgcttg attcacatgt actcttttct ttggcatagt gcaactttat   1920

gatttctgaa attcaatggt tctattgact ttttgcgtca cttaatccaa atcaaccaaa   1980

ttcagggttg aatctgaatt ggcttctcag gctcaaggta acagtgttct tgtggtttga   2040

ccaattgttt ttctttcttt tttttttttt agatttgtgg tattctggtc aagttattgt   2100

gctgtacttt gtgcgtagaa atgtgagttg tattgtcaac cccagtcagt aaagagaact   2160

tcaaaaaatt atcctcaagt gtagatttct cttaattcca tttgtgtatc atgttaaact   2220

attgttgtgg cttcttgtgt aaagacagga actgtggaac tgtgatgttg tcttttgtgt   2280

tgttaaaata agaaatgtct tatctgtata tgtatgagtc ttcctgtcat tgtatttggc   2340

acatgaatat tgtgtacaag gaattgttaa gactggtttt ccctcaacaa catatattat   2400

acttgctact ggaaaagtgt ttaagactta gctaggtttc catttagatc ttcatatctg   2460

ttgcatggaa gaaagttggg ttcttggcat agagttgcat gatatgtaag attttgtgca   2520

ttcataattg ttaaaaatct gtgttccaaa agtggacata gcatgtacag gcagttttct   2580

gtcctgtgca caaaaagttt aaaaaagttg tttaatattt gttgttgtat acccaaatac   2640

gcaccgaata aactctttat attcattcaa aga                                2673


<210>  280
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Arg Glu Lys Ser Asn Ala Cys Lys Cys Val Ser Ser Pro Ser 
            20                  25                  30          


Lys Gly Lys Thr Ser Cys Asp Lys Asn Lys Leu Asn Val Phe Ser Arg 
        35                  40                  45              


Val Lys Leu Phe Gly Ser Lys Lys Arg Arg Arg Arg Arg Pro Glu Pro 
    50                  55                  60                  


Gln Leu Lys Gly Ile Val Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His 
65                  70                  75                  80  


Leu Gln Leu Gln Ala Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp 
                85                  90                  95      


Ser Thr Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val 
            100                 105                 110         


Ala Ile Gln Gly Val Gln Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu 
        115                 120                 125             


Gly Tyr Leu Tyr Thr Ser Glu Leu Phe Thr Pro Glu Cys Lys Phe Lys 
    130                 135                 140                 


Glu Ser Val Phe Glu Asn Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr 
145                 150                 155                 160 


Arg Gln Gln Gln Ser Gly Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu 
                165                 170                 175     


Gly Glu Ile Met Lys Gly Asn His Val Lys Lys Asn Lys Pro Ala Ala 
            180                 185                 190         


His Phe Leu Pro Lys Pro Leu Lys Val Ala Met Tyr Lys Glu Pro Ser 
        195                 200                 205             


Leu His Asp Leu Thr Glu Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr 
    210                 215                 220                 


Lys Ser Arg Ser Val Ser Gly Val Leu Asn Gly Gly Lys Ser Met Ser 
225                 230                 235                 240 


His Asn Glu Ser Thr 
                245 


<210>  281
<211>  2820
<212>  DNA
<213>  Homo sapiens

<400>  281
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa     60

aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc    120

caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa    180

ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc    240

atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca    300

gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat    360

actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag    420

gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca    480

agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt    540

agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt    600

ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagctt tttgccttcg    660

agctatcggg gtaaagacct acaggaaaac tactgtcgaa atcctcgagg ggaagaaggg    720

ggaccctggt gtttcacaag caatccagag gtacgctacg aagtctgtga cattcctcag    780

tgttcagaag ttgaatgcat gacctgcaat ggggagagtt atcgaggtct catggatcat    840

acagaatcag gcaagatttg tcagcgctgg gatcatcaga caccacaccg gcacaaattc    900

ttgcctgaaa gatatcccga caagggcttt gatgataatt attgccgcaa tcccgatggc    960

cagccgaggc catggtgcta tactcttgac cctcacaccc gctgggagta ctgtgcaatt   1020

aaaacatgcg ctgacaatac tatgaatgac actgatgttc ctttggaaac aactgaatgc   1080

atccaaggtc aaggagaagg ctacaggggc actgtcaata ccatttggaa tggaattcca   1140

tgtcagcgtt gggattctca gtatcctcac gagcatgaca tgactcctga aaatttcaag   1200

tgcaaggacc tacgagaaaa ttactgccga aatccagatg ggtctgaatc accctggtgt   1260

tttaccactg atccaaacat ccgagttggc tactgctccc aaattccaaa ctgtgatatg   1320

tcacatggac aagattgtta tcgtgggaat ggcaaaaatt atatgggcaa cttatcccaa   1380

acaagatctg gactaacatg ttcaatgtgg gacaagaaca tggaagactt acatcgtcat   1440

atcttctggg aaccagatgc aagtaagctg aatgagaatt actgccgaaa tccagatgat   1500

gatgctcatg gaccctggtg ctacacggga aatccactca ttccttggga ttattgccct   1560

atttctcgtt gtgaaggtga taccacacct acaatagtca atttagacca tcccgtaata   1620

tcttgtgcca aaacgaaaca attgcgagtt gtaaatggga ttccaacacg aacaaacata   1680

ggatggatgg ttagtttgag atacagaaat aaacatatct gcggaggatc attgataaag   1740

gagagttggg ttcttactgc acgacagtgt ttcccttctc gagacttgaa agattatgaa   1800

gcttggcttg gaattcatga tgtccacgga agaggagatg agaaatgcaa acaggttctc   1860

aatgtttccc agctggtata tggccctgaa ggatcagatc tggttttaat gaagcttgcc   1920

aggcctgctg tcctggatga ttttgttagt acgattgatt tacctaatta tggatgcaca   1980

attcctgaaa agaccagttg cagtgtttat ggctggggct acactggatt gatcaactat   2040

gatggcctat tacgagtggc acatctctat ataatgggaa atgagaaatg cagccagcat   2100

catcgaggga aggtgactct gaatgagtct gaaatatgtg ctggggctga aaagattgga   2160

tcaggaccat gtgaggggga ttatggtggc ccacttgttt gtgagcaaca taaaatgaga   2220

atggttcttg gtgtcattgt tcctggtcgt ggatgtgcca ttccaaatcg tcctggtatt   2280

tttgtccgag tagcatatta tgcaaaatgg atacacaaaa ttattttaac atataaggta   2340

ccacagtcat agctgaagta agtgtgtctg aagcacccac caatacaact gtcttttaca   2400

tgaagatttc agagaatgtg gaatttaaaa tgtcacttac aacaatccta agacaactac   2460

tggagagtca tgtttgttga aattctcatt aatgtttatg ggtgttttct gttgttttgt   2520

ttgtcagtgt tattttgtca atgttgaagt gaattaaggt acatgcaagt gtaataacat   2580

atctcctgaa gatacttgaa tggattaaaa aaacacacag gtatatttgc tggatgataa   2640

agatttcatg ggaaaaaaaa tcaattaatc tgtctaagct gctttctgat gttggtttct   2700

taataatgag taaaccacaa attaaatgtt attttaacct caccaaaaca atttatacct   2760

tgtgtcccta aattgtagcc ctatattaaa ttatattaca tttcaaaaaa aaaaaaaaaa   2820


<210>  282
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                 330                 335     


His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                 375                 380                 


Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                 535                 540                 


Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                 550                 555                 560 


Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                 570                 575     


Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                 585                 590         


Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                 600                 605             


Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                 615                 620                 


Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                 630                 635                 640 


Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                 650                 655     


Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                 665                 670         


Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                 680                 685             


Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                 695                 700                 


Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Tyr Lys Val Pro Gln Ser 
                725             


<210>  283
<211>  1561
<212>  DNA
<213>  Homo sapiens

<400>  283
cgcacgccac ccgcccgccg cctgccagag ctgctcggcc cgcagccagg gggacagcgg     60

ctggtcggag gctcgcagtg ctgtcggcga gaagcagtcg ggtttggagc gcttgggtcg    120

cgttggtgcg cggtggacac gagggacccc agttcccgcg agcagctccg cgccggccct    180

gagagactaa gctgaaactg ctgctcagct cccaagatgg tgccacccaa attgcatgtg    240

cttttctgcc tctgcggctg cctggctgtg gtttatcctt ttgactggca atacataaat    300

cctgttgccc atatgaaatc atcagcatgg gtcaacaaaa tacaagtact gatggctgct    360

gcaagctttg gccaaactaa aatcccccgg ggaaatgggc cttattccgt tggttgtaca    420

gacttaatgt ttgatcacac taataagggc accttcttgc gtttatatta tccatcccaa    480

gataatgatc gccttgacac cctttggatc ccaaataaag aatatttttg gggtcttagc    540

aaatttcttg gaacacactg gcttatgggc aacattttga ggttactctt tggttcaatg    600

acaactcctg caaactggaa ttcccctctg aggcctggtg aaaaatatcc acttgttgtt    660

ttttctcatg gtcttggggc attcaggaca ctttattctg ctattggcat tgacctggca    720

tctcatgggt ttatagttgc tgctgtagaa cacagagata gatctgcatc tgcaacttac    780

tatttcaagg accaatctgc tgcagaaata ggggacaagt cttggctcta ccttagaacc    840

ctgaaacaag aggaggagac acatatacga aatgagcagg tacggcaaag agcaaaagaa    900

tgttcccaag ctctcagtct gattcttgac attgatcatg gaaagccagt gaagaatgca    960

ttagatttaa agtttgatat ggaacaactg aaggactcta ttgataggga aaaaatagca   1020

gtaattggac attcttttgg tggagcaacg gttattcaga ctcttagtga agatcagaga   1080

ttcagatgtg gtattgccct ggatgcatgg atgtttccac tgggtgatga agtatattcc   1140

agaattcctc agcccctctt ttttatcaac tctgaatatt tccaatatcc tgctaatatc   1200

ataaaaatga aaaaatgcta ctcacctgat aaagaaagaa agatgattac aatcaggggt   1260

tcagtccacc agaattttgc tgacttcact tttgcaactg gcaaaataat tggacacatg   1320

ctcaaattaa agggagacat agattcaaat gcagctattg atcttagcaa caaagcttca   1380

ttagcattct tacaaaagca tttaggactt cataaagatt ttgatcagtg ggactgcttg   1440

attgaaggag atgatgagaa tcttattcca gggaccaaca ttaacacaac caatcaacac   1500

atcatgttac agaactcttc aggaatagag aaatacaatt aggattaaaa taggtttttt   1560

a                                                                   1561


<210>  284
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15      


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30          


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45              


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60                  


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80  


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95      


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110         


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125             


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140                 


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160 


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175     


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190         


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205             


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220                 


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240 


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255     


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270         


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285             


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300                 


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320 


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335     


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350         


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365             


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Ala Ala Ile Asp Leu Ser 
    370                 375                 380                 


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400 


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415     


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430         


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440     


<210>  285
<211>  3678
<212>  DNA
<213>  Homo sapiens

<400>  285
gacgcgcgcc gggagccgcg ggccgggcca gccgggccgc cggggcccag tgcgccgcgc     60

tcgcagccgg tagcgcgcca gcgccgtagg cgctcgctcg gcagccgcgg ggccctaggc    120

cgtgccgggg agggggcgag ggcggcgccc aggcgcctgc cgccccggag gcaggatgag    180

catcgagatc ccggcgggac tgacggagct gctgcagggc ttcacggtgg aggtgctgag    240

gcaccagccc gcggacctgc tggagttcgc gctgcagcac ttcacccgcc tgcagcagga    300

gaacgagcgc aaaggcaccg cgcgcttcgg ccatgagggc aggacctggg gggacctggg    360

cgccgctgcc gggggcggca cccccagcaa gggggtcaac ttcgccgagg agcccatgca    420

gtccgactcc gaggacgggg aggaggagga ggcggcgccc gcggacgcag gggcgttcaa    480

tgctccagta ataaaccgat tcacaaggcg tgcctcagta tgtgcagaag cttataatcc    540

tgatgaagaa gaagatgatg cagagtccag gattatacat ccaaaaactg atgatcaaag    600

aaataggttg caagaggctt gcaaagacat cctgctgttt aagaatctgg atccggagca    660

gatgtctcaa gtattagatg ccatgtttga aaaattggtc aaagatgggg agcatgtaat    720

tgatcaaggt gacgatggtg acaactttta tgtaattgat agaggcacat ttgatattta    780

tgtgaaatgt gatggtgttg gaagatgtgt tggtaactat gataatcgtg ggagtttcgg    840

cgaactggcc ttaatgtaca atacacccag agcagctaca atcactgcta cctctcctgg    900

tgctctgtgg ggtttggaca gggtaacctt caggagaata attgtgaaaa acaatgccaa    960

aaagagaaaa atgtatgaaa gctttattga gtcactgcca ttccttaaat ctttggagtt   1020

ttctgaacgc ctgaaagtag tagatgtgat aggcaccaaa gtatacaacg atggagaaca   1080

aatcattgct cagggagatt cggctgattc ttttttcatt gtagaatctg gagaagtgaa   1140

aattactatg aaaagaaagg gtaaatcaga agtggaagag aatggtgcag tagaaatcgc   1200

tcgatgctcg cggggacagt actttggaga gcttgccctg gtaactaaca aacctcgagc   1260

agcttctgcc cacgccattg ggactgtcaa atgtttagca atggatgtgc aagcatttga   1320

aaggcttctg ggaccttgca tggaaattat gaaaaggaac atcgctacct atgaagaaca   1380

gttagttgcc ctgtttggaa cgaacatgga tattgttgaa cccactgcat gaagcaaaag   1440

tatggagcaa gacctgtagt gacaaaatta cacagtagtg gttagtccac tgagaatgtg   1500

tttgtgtaga tgccaagcat tttctgtgat ttcaggtttt ttcctttttt tacatttaca   1560

acgtatcaat aaacagtagt gatttaatag tcaataggct ttaacatcac tttctaaaga   1620

gtagttcata aaaaaatcaa catactgata aaatgacttt gtactccaca aaattatgac   1680

tgaaaggttt attaaaatga ttgtaatata tagaaagtat ctgtgtttaa gaagataatt   1740

aaaggatgtt atcataggct atatgtgttt tacttattca gactgataat catattagtg   1800

actatcccca tgtaagaggg cacttggcaa ttaaacatgc tacacagcat ggcatcactt   1860

ttttttataa ctcattaaac acagtaaaat tttaatcatt tttgttttaa agttttctag   1920

cttgataagt tatgtgctgg ccttggccta ttggtgaaat ggtataaaat atcatatgca   1980

gttttaaaac tttttatatt tttgcaataa agtacatttt gactttgttg gcataatgtc   2040

agtaacatac atattccagt ggttttatgg acaggcaatt tagtcattat gataataagg   2100

aaaacagtgt tttagatgag agatcattaa tgcatttttc cctcatcaag catatatctg   2160

ctttttttta ttttgcaatt ctctgtattc tatgtcttta aaaatttgat cttgacattt   2220

aatgtcacaa agttttgttt ttttaaaaag tgatttaaac ttaagatccg acattttttg   2280

tattctttaa gattttacac ctaaaaaatc tctcctatcc caaaaataat gtgggatcct   2340

tatcagcatg cccacagttt atttctttgt tcttcactag gcctgcataa tacagtccta   2400

tgtagacatc tgttcccttg ggtttccgtt ctttcttagg atggttgcca acccacaatc   2460

tcattgatca gcagccaata tgggtttgtt tggttttttt aattcttaaa aacatcctct   2520

agaggaatag aaacaaattt ttatgagcat aaccctatat aaagacaaaa tgaatttctg   2580

accttaccat atataccatt aggccttgcc attgctttaa tgtagactca tagttgaaat   2640

tagtgcagaa agaactcaga tgtactagat tttcattgtt cattgatatg ctcagtatgc   2700

tgccacataa gatgaattta attatattca accaaagcaa tatactctta catgatttct   2760

aggccccatg acccagtgtc tagagacatt aattctaacc agttgtttgc ttttaaatga   2820

gtgatttcat tttgggaaac aggtttcaaa tgaatatata tacatgggta aaattactct   2880

gtgctagtgt agtcttacta gagaatgttt atggtcccac ttgtatatga aaatgtggtt   2940

agaatgttaa ttggataatg tatatataag aagttaaagt atgtaaagta taacttcagc   3000

cacattttta gaacactgtt taacattttt gcaaaacctt cttgtaggaa aagagagctc   3060

tctacatgaa gatgacttgt tttatatttc agattttatt ttaaaagcca tgtctgttaa   3120

acaagaaaaa acacaaaaga actccagatt cctggttcat cattctgtat tcttactcac   3180

tttttcaagt tatctatttt gttgcataaa ctaattgtta actattcatg gaacagcaaa   3240

cgcctgttta ataaagaact ttgaccaagg ctataaatgc cacgtacatt attttcagta   3300

ttgttggtta tatttaaatt ttccttacaa taaagcacac ttttataata aaatacatga   3360

attattgttt ttcatacttt tttgcttgtt tctttaaagt tttctgacgt gcataatgca   3420

taattcattg aaaagcatga tagcaatgtg gcatgtggaa gcgaaccccc agggcataac   3480

atagtaagaa agtatggttc tgtatggcaa taggttttta aaattattag ctattcatca   3540

tgtgtgggag aaataattgt ggtgtgttgc agatttattt ggccatttag aataaccaaa   3600

tcaatctggc taactaggaa tttatgtgta aaattatctg attaaaacag ctcaagtttg   3660

aaaaaaaaaa aaaaaaaa                                                 3678


<210>  286
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe 
1               5                   10                  15      


Thr Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala 
            20                  25                  30          


Leu Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Thr 
        35                  40                  45              


Ala Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Leu Gly Ala Ala 
    50                  55                  60                  


Ala Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro 
65                  70                  75                  80  


Met Gln Ser Asp Ser Glu Asp Gly Glu Glu Glu Glu Ala Ala Pro Ala 
                85                  90                  95      


Asp Ala Gly Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg 
            100                 105                 110         


Ala Ser Val Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp 
        115                 120                 125             


Ala Glu Ser Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg 
    130                 135                 140                 


Leu Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro 
145                 150                 155                 160 


Glu Gln Met Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys 
                165                 170                 175     


Asp Gly Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr 
            180                 185                 190         


Val Ile Asp Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val 
        195                 200                 205             


Gly Arg Cys Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu 
    210                 215                 220                 


Ala Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser 
225                 230                 235                 240 


Pro Gly Ala Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile 
                245                 250                 255     


Val Lys Asn Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu 
            260                 265                 270         


Ser Leu Pro Phe Leu Lys Ser Leu Glu Phe Ser Glu Arg Leu Lys Val 
        275                 280                 285             


Val Asp Val Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile 
    290                 295                 300                 


Ala Gln Gly Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu 
305                 310                 315                 320 


Val Lys Ile Thr Met Lys Arg Lys Gly Lys Ser Glu Val Glu Glu Asn 
                325                 330                 335     


Gly Ala Val Glu Ile Ala Arg Cys Ser Arg Gly Gln Tyr Phe Gly Glu 
            340                 345                 350         


Leu Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile 
        355                 360                 365             


Gly Thr Val Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu 
    370                 375                 380                 


Leu Gly Pro Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu 
385                 390                 395                 400 


Glu Gln Leu Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro 
                405                 410                 415     


Thr Ala 
        


<210>  287
<211>  3089
<212>  DNA
<213>  Homo sapiens

<400>  287
agcagttcct cctaactcct gccagaaaca gctctcctca acatgagagc tgcacccctc     60

ctcctggcca gggcagcaag ccttagcctt ggcttcttgt ttctgctttt tttctggcta    120

gaccgaagtg tactagccaa ggagttgaag tttgtgactt tggtgtttcg gcatggagac    180

cgaagtccca ttgacacctt tcccactgac cccataaagg aatcctcatg gccacaagga    240

tttggccaac tcacccagct gggcatggag cagcattatg aacttggaga gtatataaga    300

aagagatata gaaaattctt gaatgagtcc tataaacatg aacaggttta tattcgaagc    360

acagacgttg accggacttt gatgagtgct atgacaaacc tggcagccct gtttccccca    420

gaaggtgtca gcatctggaa tcctatccta ctctggcagc ccatcccggt gcacacagtt    480

cctctttctg aagatcagtt gctatacctg cctttcagga actgccctcg ttttcaagaa    540

cttgagagtg agactttgaa atcagaggaa ttccagaaga ggctgcaccc ttataaggat    600

tttatagcta ccttgggaaa actttcagga ttacatggcc aggacctttt tggaatttgg    660

agtaaagtct acgacccttt atattgtgag agtgttcaca atttcacttt accctcctgg    720

gccactgagg acaccatgac taagttgaga gaattgtcag aattgtccct cctgtccctc    780

tatggaattc acaagcagaa agagaaatct aggctccaag ggggtgtcct ggtcaatgaa    840

atcctcaatc acatgaagag agcaactcag ataccaagct acaaaaaact tatcatgtat    900

tctgcgcatg acactactgt gagtggccta cagatggcgc tagatgttta caacggactc    960

cttcctccct atgcttcttg ccacttgacg gaattgtact ttgagaaggg ggagtacttt   1020

gtggagatgt actaccggaa tgagacgcag cacgagccgt atcccctcat gctacctggc   1080

tgcagcccca gctgtcctct ggagaggttt gctgagctgg ttggccctgt gatccctcaa   1140

gactggtcca cggagtgtat gaccacaaac agccatcaag gtactgagga cagtacagat   1200

tagtgtgcac agagatctct gtagaaagag tagctgccct ttctcagggc agatgatgct   1260

ttgagaacat actttggcca ttacccccca gctttgagga aaatgggctt tggatgatta   1320

ttttatgttt tagggacccc caacctcagg caattcctac ctcttcacct gaccctgccc   1380

ccacttgcca taaaacttag ctaagttttg ttttgttttt cagcgttaat gtaaaggggc   1440

agcagtgcca aaatataatc agagataaag cttaggtcaa agttcataga gttcccatga   1500

actatatgac tggccacaca ggatcttttg tatttaagga ttctgagatt ttgcttgagc   1560

aggattagat aagtctgttc tttaaatttc tgaaatggaa cagatttcaa aaaaaattcc   1620

cacaatctag ggtgggaaca aggaaggaaa gatgtgaata ggctgatggg gaaaaaacca   1680

atttacccat cagttccagc cttctctcaa ggagaggcaa agaaaggaga tacagtggag   1740

acatctggaa agttttctcc actggaaaac tgctactatc tgtttttata tttctgttaa   1800

aatatatgag gctacagaac taaaaattaa aacctctttg tgtcccttgg tcctggaaca   1860

tttatgttcc ttttaaagaa acaaaaatca aactttacag aaagatttga tgtatgtaat   1920

acatatagca gctcttgaag tatatatatc atagcaaata agtcatctga tgagaacaag   1980

ctatttgggc acaacacatc aggaaagaga gcaccacgtg atggagtttc tccagaagct   2040

ccagtgataa gagatgttga ctctaaagtt gatttaaggc caggcatggt ggtttacgcc   2100

tataatccca gcattttggg actccgaggt gggcagatca cttgagctca ggagctcaag   2160

atcagcctgg gcaacatggt gaaaccttgt ctctacataa aatacaaaaa cttagatggg   2220

catggtgctg tgtgcctata gtccactact tgtggggcta aggcaggagg atcacttgag   2280

ccccggaggt cgaggctaca gtgacccaag agtgcactac tgtactccag ccagggcaag   2340

agagcgagac cctgtctcaa taaataaata aataaataaa taaataaata aataaaaaca   2400

aagttgatta agaaaggaag tataggccag gcacagtggc tcacacctgt aatccttgca   2460

ttttggaagg ctgaggcagg aggatcactt taggcctggt gtgttcaaga ccagcctggt   2520

caacatagtg agacactgtc tctaccaaaa aaaggaagga agggacacat atcaaactga   2580

aacaaaatta gaaatgtaat tatgttatgt tctaagtgcc tccaagttca aaacttattg   2640

gaatgttgag agtgtggtta cgaaatacgt taggaggaca aaaggaatgt gtaagtcttt   2700

aatgccgata tcttcagaaa acctaagcaa acttacaggt cctgctgaaa ctgcccactc   2760

tgcaagaaga aatcatgata tagctttcca tgtggcagat ctacatgtct agagaacact   2820

gtgctctatt accattatgg ataaagatga gatggtttct agagatggtt tctactggct   2880

gccagaatct agagcaaagc catcccccct cctggttggt cacagaatga ctgacaaaga   2940

catcgattga tatgcttctt tgtgttattt ccctcccaag taaatgtttg tccttgggtc   3000

cattttctat gcttgtaact gtcttctagc agtgagccaa atgtaaaata gtgaataaag   3060

tcattattag gaagttcaaa aaaaaaaaa                                     3089


<210>  288
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
    370                 375                 380                 


Thr Asp 
385     


<210>  289
<211>  3737
<212>  DNA
<213>  Homo sapiens

<400>  289
ggcgtccgcg cacacctccc cgcgccgccg ccgccaccgc ccgcactccg ccgcctctgc     60

ccgcaaccgc tgagccatcc atgggggtcg cgggccgcaa ccgtcccggg gcggcctggg    120

cggtgctgct gctgctgctg ctgctgccgc cactgctgct gctggcgggg gccgtcccgc    180

cgggtcgggg ccgtgccgcg gggccgcagg aggatgtaga tgagtgtgcc caagggctag    240

atgactgcca tgccgacgcc ctgtgtcaga acacacccac ctcctacaag tgctcctgca    300

agcctggcta ccaaggggaa ggcaggcagt gtgaggacat cgatgaatgt ggaaatgagc    360

tcaatggagg ctgtgtccat gactgtttga atattccagg caattatcgt tgcacttgtt    420

ttgatggctt catgttggct catgacggtc ataattgtct tgatgtggac gagtgcctgg    480

agaacaatgg cggctgccag catacctgtg tcaacgtcat ggggagctat gagtgctgct    540

gcaaggaggg gtttttcctg agtgacaatc agcacacctg cattcaccgc tcggaagagg    600

gcctgagctg catgaataag gatcacggct gtagtcacat ctgcaaggag gccccaaggg    660

gcagcgtcgc ctgtgagtgc aggcctggtt ttgagctggc caagaaccag agagactgca    720

tcttgacctg taaccatggg aacggtgggt gccagcactc ctgtgacgat acagccgatg    780

gcccagagtg cagctgccat ccacagtaca agatgcacac agatgggagg agctgccttg    840

agcgagagga cactgtcctg gaggtgacag agagcaacac cacatcagtg gtggatgggg    900

ataaacgggt gaaacggcgg ctgctcatgg aaacgtgtgc tgtcaacaat ggaggctgtg    960

accgcacctg taaggatact tcgacaggtg tccactgcag ttgtcctgtt ggattcactc   1020

tccagttgga tgggaagaca tgtaaagata ttgatgagtg ccagacccgc aatggaggtt   1080

gtgatcattt ctgcaaaaac atcgtgggca gttttgactg cggctgcaag aaaggattta   1140

aattattaac agatgagaag tcttgccaag atgtggatga gtgctctttg gataggacct   1200

gtgaccacag ctgcatcaac caccctggca catttgcttg tgcttgcaac cgagggtaca   1260

ccctgtatgg cttcacccac tgtggagaca ccaatgagtg cagcatcaac aacggaggct   1320

gtcagcaggt ctgtgtgaac acagtgggca gctatgaatg ccagtgccac cctgggtaca   1380

agctccactg gaataaaaaa gactgtgtgg aagtgaaggg gctcctgccc acaagtgtgt   1440

caccccgtgt gtccctgcac tgcggtaaga gtggtggagg agacgggtgc ttcctcagat   1500

gtcactctgg cattcacctc tcttcagatg tcaccaccat caggacaagt gtaaccttta   1560

agctaaatga aggcaagtgt agtttgaaaa atgctgagct gtttcccgag ggtctgcgac   1620

cagcactacc agagaagcac agctcagtaa aagagagctt ccgctacgta aaccttacat   1680

gcagctctgg caagcaagtc ccaggagccc ctggccgacc aagcacccct aaggaaatgt   1740

ttatcactgt tgagtttgag cttgaaacta accaaaagga ggtgacagct tcttgtgacc   1800

tgagctgcat cgtaaagcga accgagaagc ggctccgtaa agccatccgc acgctcagaa   1860

aggccgtcca cagggagcag tttcacctcc agctctcagg catgaacctc gacgtggcta   1920

aaaagcctcc cagaacatct gaacgccagg cagagtcctg tggagtgggc cagggtcatg   1980

cagaaaacca atgtgtcagt tgcagggctg ggacctatta tgatggagca cgagaacgct   2040

gcattttatg tccaaatgga accttccaaa atgaggaagg acaaatgact tgtgaaccat   2100

gcccaagacc aggaaattct ggggccctga agaccccaga agcttggaat atgtctgaat   2160

gtggaggtct gtgtcaacct ggtgaatatt ctgcagatgg ctttgcacct tgccagctct   2220

gtgccctggg cacgttccag cctgaagctg gtcgaacttc ctgcttcccc tgtggaggag   2280

gccttgccac caaacatcag ggagctactt cctttcagga ctgtgaaacc agagttcaat   2340

gttcacctgg acatttctac aacaccacca ctcaccgatg tattcgttgc ccagtgggaa   2400

cataccagcc tgaatttgga aaaaataatt gtgtttcttg cccaggaaat actacgactg   2460

actttgatgg ctccacaaac ataacccagt gtaaaaacag aagatgtgga ggggagctgg   2520

gagatttcac tgggtacatt gaatccccaa actacccagg caattaccca gccaacaccg   2580

agtgtacgtg gaccatcaac ccacccccca agcgccgcat cctgatcgtg gtccctgaga   2640

tcttcctgcc catagaggac gactgtgggg actatctggt gatgcggaaa acctcttcat   2700

ccaattctgt gacaacatat gaaacctgcc agacctacga acgccccatc gccttcacct   2760

ccaggtcaaa gaagctgtgg attcagttca agtccaatga agggaacagc gctagagggt   2820

tccaggtccc atacgtgaca tatgatgagg actaccagga actcattgaa gacatagttc   2880

gagatggcag gctctatgca tctgagaacc atcaggaaat acttaaggat aagaaactta   2940

tcaaggctct gtttgatgtc ctggcccatc cccagaacta tttcaagtac acagcccagg   3000

agtcccgaga gatgtttcca agatcgttca tccgattgct acgttccaaa gtgtccaggt   3060

ttttgagacc ttacaaatga ctcagcccac gtgccactca atacaaatgt tctgctatag   3120

ggttggtggg acagagctgt cttccttctg catgtcagca cagtcgggta ttgctgcctc   3180

ccgtatcagt gactcattag agttcaattt ttatagataa tacagatatt ttggtaaatt   3240

gaacttggtt tttctttccc agcatcgtgg atgtagactg agaatggctt tgagtggcat   3300

cagcttctca ctgctgtggg cggatgtctt ggatagatca cgggctggct gagctggact   3360

ttggtcagcc taggtgagac tcacctgtcc ttctggggtc ttactcctcc tcaaggagtc   3420

tgtagtggaa aggaggccac agaataagct gcttattctg aaacttcagc ttcctctagc   3480

ccggccctct ctaagggagc cctctgcact cgtgtgcagg ctctgaccag gcagaacagg   3540

caagagggga gggaaggaga cccctgcagg ctccctccac ccaccttgag acctgggagg   3600

actcagtttc tccacagcct tctccagcct gtgtgataca agtttgatcc caggaacttg   3660

agttctaagc agtgctcgtg aaaaaaaaaa gcagaaagaa ttagaaataa ataaaaacta   3720

agcacttctg gagacat                                                  3737


<210>  290
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Gly Val Ala Gly Arg Asn Arg Pro Gly Ala Ala Trp Ala Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu Leu Ala Gly Ala Val 
            20                  25                  30          


Pro Pro Gly Arg Gly Arg Ala Ala Gly Pro Gln Glu Asp Val Asp Glu 
        35                  40                  45              


Cys Ala Gln Gly Leu Asp Asp Cys His Ala Asp Ala Leu Cys Gln Asn 
    50                  55                  60                  


Thr Pro Thr Ser Tyr Lys Cys Ser Cys Lys Pro Gly Tyr Gln Gly Glu 
65                  70                  75                  80  


Gly Arg Gln Cys Glu Asp Ile Asp Glu Cys Gly Asn Glu Leu Asn Gly 
                85                  90                  95      


Gly Cys Val His Asp Cys Leu Asn Ile Pro Gly Asn Tyr Arg Cys Thr 
            100                 105                 110         


Cys Phe Asp Gly Phe Met Leu Ala His Asp Gly His Asn Cys Leu Asp 
        115                 120                 125             


Val Asp Glu Cys Leu Glu Asn Asn Gly Gly Cys Gln His Thr Cys Val 
    130                 135                 140                 


Asn Val Met Gly Ser Tyr Glu Cys Cys Cys Lys Glu Gly Phe Phe Leu 
145                 150                 155                 160 


Ser Asp Asn Gln His Thr Cys Ile His Arg Ser Glu Glu Gly Leu Ser 
                165                 170                 175     


Cys Met Asn Lys Asp His Gly Cys Ser His Ile Cys Lys Glu Ala Pro 
            180                 185                 190         


Arg Gly Ser Val Ala Cys Glu Cys Arg Pro Gly Phe Glu Leu Ala Lys 
        195                 200                 205             


Asn Gln Arg Asp Cys Ile Leu Thr Cys Asn His Gly Asn Gly Gly Cys 
    210                 215                 220                 


Gln His Ser Cys Asp Asp Thr Ala Asp Gly Pro Glu Cys Ser Cys His 
225                 230                 235                 240 


Pro Gln Tyr Lys Met His Thr Asp Gly Arg Ser Cys Leu Glu Arg Glu 
                245                 250                 255     


Asp Thr Val Leu Glu Val Thr Glu Ser Asn Thr Thr Ser Val Val Asp 
            260                 265                 270         


Gly Asp Lys Arg Val Lys Arg Arg Leu Leu Met Glu Thr Cys Ala Val 
        275                 280                 285             


Asn Asn Gly Gly Cys Asp Arg Thr Cys Lys Asp Thr Ser Thr Gly Val 
    290                 295                 300                 


His Cys Ser Cys Pro Val Gly Phe Thr Leu Gln Leu Asp Gly Lys Thr 
305                 310                 315                 320 


Cys Lys Asp Ile Asp Glu Cys Gln Thr Arg Asn Gly Gly Cys Asp His 
                325                 330                 335     


Phe Cys Lys Asn Ile Val Gly Ser Phe Asp Cys Gly Cys Lys Lys Gly 
            340                 345                 350         


Phe Lys Leu Leu Thr Asp Glu Lys Ser Cys Gln Asp Val Asp Glu Cys 
        355                 360                 365             


Ser Leu Asp Arg Thr Cys Asp His Ser Cys Ile Asn His Pro Gly Thr 
    370                 375                 380                 


Phe Ala Cys Ala Cys Asn Arg Gly Tyr Thr Leu Tyr Gly Phe Thr His 
385                 390                 395                 400 


Cys Gly Asp Thr Asn Glu Cys Ser Ile Asn Asn Gly Gly Cys Gln Gln 
                405                 410                 415     


Val Cys Val Asn Thr Val Gly Ser Tyr Glu Cys Gln Cys His Pro Gly 
            420                 425                 430         


Tyr Lys Leu His Trp Asn Lys Lys Asp Cys Val Glu Val Lys Gly Leu 
        435                 440                 445             


Leu Pro Thr Ser Val Ser Pro Arg Val Ser Leu His Cys Gly Lys Ser 
    450                 455                 460                 


Gly Gly Gly Asp Gly Cys Phe Leu Arg Cys His Ser Gly Ile His Leu 
465                 470                 475                 480 


Ser Ser Asp Val Thr Thr Ile Arg Thr Ser Val Thr Phe Lys Leu Asn 
                485                 490                 495     


Glu Gly Lys Cys Ser Leu Lys Asn Ala Glu Leu Phe Pro Glu Gly Leu 
            500                 505                 510         


Arg Pro Ala Leu Pro Glu Lys His Ser Ser Val Lys Glu Ser Phe Arg 
        515                 520                 525             


Tyr Val Asn Leu Thr Cys Ser Ser Gly Lys Gln Val Pro Gly Ala Pro 
    530                 535                 540                 


Gly Arg Pro Ser Thr Pro Lys Glu Met Phe Ile Thr Val Glu Phe Glu 
545                 550                 555                 560 


Leu Glu Thr Asn Gln Lys Glu Val Thr Ala Ser Cys Asp Leu Ser Cys 
                565                 570                 575     


Ile Val Lys Arg Thr Glu Lys Arg Leu Arg Lys Ala Ile Arg Thr Leu 
            580                 585                 590         


Arg Lys Ala Val His Arg Glu Gln Phe His Leu Gln Leu Ser Gly Met 
        595                 600                 605             


Asn Leu Asp Val Ala Lys Lys Pro Pro Arg Thr Ser Glu Arg Gln Ala 
    610                 615                 620                 


Glu Ser Cys Gly Val Gly Gln Gly His Ala Glu Asn Gln Cys Val Ser 
625                 630                 635                 640 


Cys Arg Ala Gly Thr Tyr Tyr Asp Gly Ala Arg Glu Arg Cys Ile Leu 
                645                 650                 655     


Cys Pro Asn Gly Thr Phe Gln Asn Glu Glu Gly Gln Met Thr Cys Glu 
            660                 665                 670         


Pro Cys Pro Arg Pro Gly Asn Ser Gly Ala Leu Lys Thr Pro Glu Ala 
        675                 680                 685             


Trp Asn Met Ser Glu Cys Gly Gly Leu Cys Gln Pro Gly Glu Tyr Ser 
    690                 695                 700                 


Ala Asp Gly Phe Ala Pro Cys Gln Leu Cys Ala Leu Gly Thr Phe Gln 
705                 710                 715                 720 


Pro Glu Ala Gly Arg Thr Ser Cys Phe Pro Cys Gly Gly Gly Leu Ala 
                725                 730                 735     


Thr Lys His Gln Gly Ala Thr Ser Phe Gln Asp Cys Glu Thr Arg Val 
            740                 745                 750         


Gln Cys Ser Pro Gly His Phe Tyr Asn Thr Thr Thr His Arg Cys Ile 
        755                 760                 765             


Arg Cys Pro Val Gly Thr Tyr Gln Pro Glu Phe Gly Lys Asn Asn Cys 
    770                 775                 780                 


Val Ser Cys Pro Gly Asn Thr Thr Thr Asp Phe Asp Gly Ser Thr Asn 
785                 790                 795                 800 


Ile Thr Gln Cys Lys Asn Arg Arg Cys Gly Gly Glu Leu Gly Asp Phe 
                805                 810                 815     


Thr Gly Tyr Ile Glu Ser Pro Asn Tyr Pro Gly Asn Tyr Pro Ala Asn 
            820                 825                 830         


Thr Glu Cys Thr Trp Thr Ile Asn Pro Pro Pro Lys Arg Arg Ile Leu 
        835                 840                 845             


Ile Val Val Pro Glu Ile Phe Leu Pro Ile Glu Asp Asp Cys Gly Asp 
    850                 855                 860                 


Tyr Leu Val Met Arg Lys Thr Ser Ser Ser Asn Ser Val Thr Thr Tyr 
865                 870                 875                 880 


Glu Thr Cys Gln Thr Tyr Glu Arg Pro Ile Ala Phe Thr Ser Arg Ser 
                885                 890                 895     


Lys Lys Leu Trp Ile Gln Phe Lys Ser Asn Glu Gly Asn Ser Ala Arg 
            900                 905                 910         


Gly Phe Gln Val Pro Tyr Val Thr Tyr Asp Glu Asp Tyr Gln Glu Leu 
        915                 920                 925             


Ile Glu Asp Ile Val Arg Asp Gly Arg Leu Tyr Ala Ser Glu Asn His 
    930                 935                 940                 


Gln Glu Ile Leu Lys Asp Lys Lys Leu Ile Lys Ala Leu Phe Asp Val 
945                 950                 955                 960 


Leu Ala His Pro Gln Asn Tyr Phe Lys Tyr Thr Ala Gln Glu Ser Arg 
                965                 970                 975     


Glu Met Phe Pro Arg Ser Phe Ile Arg Leu Leu Arg Ser Lys Val Ser 
            980                 985                 990         


Arg Phe Leu Arg Pro Tyr Lys 
        995                 


<210>  291
<211>  1758
<212>  DNA
<213>  Homo sapiens

<400>  291
cacgagcggc acgaggattt ccagctcagc gatgccccca ggtccctggg agagctgctt     60

ctgggtgggg ggcctcattt tgtggctcag cgttggaagt tcaggggatg cacctcctac    120

cccacagcca aagtgcgctg acttccagag cgccaacctt tttgaaggca ccgatctcaa    180

agtccagttt ctcctctttg tcccttcgaa tcctagctgt gggcagctag tagaaggaag    240

cagtgacctc caaaactctg ggttcaatgc cactctggga accaaactaa ttatccatgg    300

attcagggtt ttaggaacaa agccttcctg gattgacaca tttattagaa cccttctgcg    360

tgcaacgaat gctaatgtga ttgccgtgga ctggatttat gggtctacag gagtctactt    420

ctcagctgtg aaaaatgtga ttaagttgag cctcgagatc tcccttttcc tcaataaact    480

cctggtgctg ggtgtgtcgg aatcctcaat ccacatcatt ggtgttagcc tgggggccca    540

cgttgggggc atggtgggac agctcttcgg aggccagctg ggacagatca caggcctgga    600

ccccgctgga cctgagtaca ccagggccag tgtggaagag cgcttggatg ctggagatgc    660

cctcttcgtg gaagccatcc acacagacac cgacaatttg ggtattcgga ttcccgttgg    720

acatgtggac tacttcgtca acggaggcca agaccaacct ggctgcccca ccttctttta    780

cgcaggttat agttatctga tctgtgatca catgagggct gtgcacctct acatcagcgc    840

cctggagaat tcctgtccac tgatggcctt tccctgtgcc agctacaagg ccttccttgc    900

tggacgctgt ctggattgct ttaacccttt tctgctttcc tgcccaagga taggactggt    960

ggaacaaggt ggtgtcaaga tagagccgct ccccaaggaa gtgaaagtct acctcctgac   1020

tacttccagt gctccgtact gcatgcatca cagcctcgtg gagtttcact tgaaggaact   1080

gagaaacaag gacaccaaca tcgaggttac cttccttagc agtaacatca cctcttcatc   1140

taagatcacc atacctaagc agcaacgcta tgggaaagga atcatagccc atgccacccc   1200

acaatgccag ataaaccaag tgaaattcaa gtttcagtct tccaaccgag tttggaaaaa   1260

agaccggact accattattg ggaagttctg cactgccctt ttgcctgtca atgacagaga   1320

aaagatggtc tgcttacctg aaccagtgaa cttacaagca agtgtgactg tttcctgtga   1380

cctgaagata gcctgtgtgt agtttaacct gggcaggaca catctccctg catttttttt   1440

tttttttttt gagagagagg tgtgatgagg gatgtgtgtg tgcagcttat tgtagaccat   1500

tactactaag gagaaaagca aagctctttc ttattttcct cataatcagc taccctggag   1560

gggagggaga actcatttta cagaacttgg tttcctttgc cgatcttatg tacataccca   1620

ttttagcttt cccatgcata cttaactgca cttgctttat ctccttgggc attcgtactt   1680

aggattcaat agaaacatgt acagggtaaa caatttttta aaaataaaac ttcatggagt   1740

aaaaaaaaaa aaaaaaaa                                                 1758


<210>  292
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Pro Pro Gly Pro Trp Glu Ser Cys Phe Trp Val Gly Gly Leu Ile 
1               5                   10                  15      


Leu Trp Leu Ser Val Gly Ser Ser Gly Asp Ala Pro Pro Thr Pro Gln 
            20                  25                  30          


Pro Lys Cys Ala Asp Phe Gln Ser Ala Asn Leu Phe Glu Gly Thr Asp 
        35                  40                  45              


Leu Lys Val Gln Phe Leu Leu Phe Val Pro Ser Asn Pro Ser Cys Gly 
    50                  55                  60                  


Gln Leu Val Glu Gly Ser Ser Asp Leu Gln Asn Ser Gly Phe Asn Ala 
65                  70                  75                  80  


Thr Leu Gly Thr Lys Leu Ile Ile His Gly Phe Arg Val Leu Gly Thr 
                85                  90                  95      


Lys Pro Ser Trp Ile Asp Thr Phe Ile Arg Thr Leu Leu Arg Ala Thr 
            100                 105                 110         


Asn Ala Asn Val Ile Ala Val Asp Trp Ile Tyr Gly Ser Thr Gly Val 
        115                 120                 125             


Tyr Phe Ser Ala Val Lys Asn Val Ile Lys Leu Ser Leu Glu Ile Ser 
    130                 135                 140                 


Leu Phe Leu Asn Lys Leu Leu Val Leu Gly Val Ser Glu Ser Ser Ile 
145                 150                 155                 160 


His Ile Ile Gly Val Ser Leu Gly Ala His Val Gly Gly Met Val Gly 
                165                 170                 175     


Gln Leu Phe Gly Gly Gln Leu Gly Gln Ile Thr Gly Leu Asp Pro Ala 
            180                 185                 190         


Gly Pro Glu Tyr Thr Arg Ala Ser Val Glu Glu Arg Leu Asp Ala Gly 
        195                 200                 205             


Asp Ala Leu Phe Val Glu Ala Ile His Thr Asp Thr Asp Asn Leu Gly 
    210                 215                 220                 


Ile Arg Ile Pro Val Gly His Val Asp Tyr Phe Val Asn Gly Gly Gln 
225                 230                 235                 240 


Asp Gln Pro Gly Cys Pro Thr Phe Phe Tyr Ala Gly Tyr Ser Tyr Leu 
                245                 250                 255     


Ile Cys Asp His Met Arg Ala Val His Leu Tyr Ile Ser Ala Leu Glu 
            260                 265                 270         


Asn Ser Cys Pro Leu Met Ala Phe Pro Cys Ala Ser Tyr Lys Ala Phe 
        275                 280                 285             


Leu Ala Gly Arg Cys Leu Asp Cys Phe Asn Pro Phe Leu Leu Ser Cys 
    290                 295                 300                 


Pro Arg Ile Gly Leu Val Glu Gln Gly Gly Val Lys Ile Glu Pro Leu 
305                 310                 315                 320 


Pro Lys Glu Val Lys Val Tyr Leu Leu Thr Thr Ser Ser Ala Pro Tyr 
                325                 330                 335     


Cys Met His His Ser Leu Val Glu Phe His Leu Lys Glu Leu Arg Asn 
            340                 345                 350         


Lys Asp Thr Asn Ile Glu Val Thr Phe Leu Ser Ser Asn Ile Thr Ser 
        355                 360                 365             


Ser Ser Lys Ile Thr Ile Pro Lys Gln Gln Arg Tyr Gly Lys Gly Ile 
    370                 375                 380                 


Ile Ala His Ala Thr Pro Gln Cys Gln Ile Asn Gln Val Lys Phe Lys 
385                 390                 395                 400 


Phe Gln Ser Ser Asn Arg Val Trp Lys Lys Asp Arg Thr Thr Ile Ile 
                405                 410                 415     


Gly Lys Phe Cys Thr Ala Leu Leu Pro Val Asn Asp Arg Glu Lys Met 
            420                 425                 430         


Val Cys Leu Pro Glu Pro Val Asn Leu Gln Ala Ser Val Thr Val Ser 
        435                 440                 445             


Cys Asp Leu Lys Ile Ala Cys Val 
    450                 455     


<210>  293
<211>  1874
<212>  DNA
<213>  Homo sapiens

<400>  293
gcaggtgagg cacgtttagc ctgagccggc cacggactcc acttcccctg ctcttccccc     60

agtggcaaat ccgcgccacc tcgcaaaccc ccaactcagg cacttgggcc ccttttgggc    120

cccctctcgc tcctcccttt aggcacctcc ctgggcccgc ccacggtctc cccccagttt    180

gggactgcgt cataagtatc ccagacctcg gcttgcagta gtgttagact gaagataaag    240

taagtgctgt ttgggctaac aggatctcct cttgcagtct gcagcccagg acgctgattc    300

cagcagcgcc ttaccgcgca gcccgaagat tcactatggt gaaaatcgcc ttcaataccc    360

ctaccgccgt gcaaaaggag gaggcgcggc aagacgtgga ggccctcctg agccgcacgg    420

tcagaactca gatactgacc ggcaaggagc tccgagttgc cacccaggaa aaagagggct    480

cctctgggag atgtatgctt actctcttag gcctttcatt catcttggca ggacttattg    540

ttggtggagc ctgcatttac aagtacttca tgcccaagag caccatttac cgtggagaga    600

tgtgcttttt tgattctgag gatcctgcaa attcccttcg tggaggagag cctaacttcc    660

tgcctgtgac tgaggaggct gacattcgtg aggatgacaa cattgcaatc attgatgtgc    720

ctgtccccag tttctctgat agtgaccctg cagcaattat tcatgacttt gaaaagggaa    780

tgactgctta cctggacttg ttgctgggga actgctatct gatgcccctc aatacttcta    840

ttgttatgcc tccaaaaaat ctggtagagc tctttggcaa actggcgagt ggcagatatc    900

tgcctcaaac ttatgtggtt cgagaagacc tagttgctgt ggaggaaatt cgtgatgtta    960

gtaaccttgg catctttatt taccaacttt gcaataacag aaagtccttc cgccttcgtc   1020

gcagagacct cttgctgggt ttcaacaaac gtgccattga taaatgctgg aagattagac   1080

acttccccaa cgaatttatt gttgagacca agatctgtca agagtaagag gcaacagata   1140

gagtgtcctt ggtaataaga agtcagagat ttacaatatg actttaacat taaggtttat   1200

gggatactca agatatttac tcatgcattt actctattgc ttatgcttta aaaaaaggaa   1260

aaaaaaaaac tactaaccac tgcaagctct tgtcaaattt tagtttaatt ggcattgctt   1320

gttttttgaa actgaaatta catgagtttc attttttctt tgaatttata gggtttagat   1380

ttctgaaagc agcatgaata tatcacctaa catcctgaca ataaattcca tccgttgttt   1440

tttttgtttg tttgtttttt cttttccttt aagtaagctc tttattcatc ttatggtgga   1500

gcaattttaa aatttgaaat attttaaatt gtttttgaac tttttgtgta aaatatatca   1560

gatctcaaca ttgttggttt cttttgtttt tcattttgta caactttctt gaatttagaa   1620

attacatctt tgcagttctg ttaggtgctc tgtaattaac ctgacttata tgtgaacaat   1680

tttcatgaga cagtcatttt taactaatgc agtgattctt tctcactact atctgtattg   1740

tggaatgcac aaaattgtgt aggtgctgaa tgctgtaagg agtttaggtt gtatgaattc   1800

tacaacccta taataaattt tactctatac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1860

aaaaaaaaaa aaaa                                                     1874


<210>  294
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Val Lys Ile Ala Phe Asn Thr Pro Thr Ala Val Gln Lys Glu Glu 
1               5                   10                  15      


Ala Arg Gln Asp Val Glu Ala Leu Leu Ser Arg Thr Val Arg Thr Gln 
            20                  25                  30          


Ile Leu Thr Gly Lys Glu Leu Arg Val Ala Thr Gln Glu Lys Glu Gly 
        35                  40                  45              


Ser Ser Gly Arg Cys Met Leu Thr Leu Leu Gly Leu Ser Phe Ile Leu 
    50                  55                  60                  


Ala Gly Leu Ile Val Gly Gly Ala Cys Ile Tyr Lys Tyr Phe Met Pro 
65                  70                  75                  80  


Lys Ser Thr Ile Tyr Arg Gly Glu Met Cys Phe Phe Asp Ser Glu Asp 
                85                  90                  95      


Pro Ala Asn Ser Leu Arg Gly Gly Glu Pro Asn Phe Leu Pro Val Thr 
            100                 105                 110         


Glu Glu Ala Asp Ile Arg Glu Asp Asp Asn Ile Ala Ile Ile Asp Val 
        115                 120                 125             


Pro Val Pro Ser Phe Ser Asp Ser Asp Pro Ala Ala Ile Ile His Asp 
    130                 135                 140                 


Phe Glu Lys Gly Met Thr Ala Tyr Leu Asp Leu Leu Leu Gly Asn Cys 
145                 150                 155                 160 


Tyr Leu Met Pro Leu Asn Thr Ser Ile Val Met Pro Pro Lys Asn Leu 
                165                 170                 175     


Val Glu Leu Phe Gly Lys Leu Ala Ser Gly Arg Tyr Leu Pro Gln Thr 
            180                 185                 190         


Tyr Val Val Arg Glu Asp Leu Val Ala Val Glu Glu Ile Arg Asp Val 
        195                 200                 205             


Ser Asn Leu Gly Ile Phe Ile Tyr Gln Leu Cys Asn Asn Arg Lys Ser 
    210                 215                 220                 


Phe Arg Leu Arg Arg Arg Asp Leu Leu Leu Gly Phe Asn Lys Arg Ala 
225                 230                 235                 240 


Ile Asp Lys Cys Trp Lys Ile Arg His Phe Pro Asn Glu Phe Ile Val 
                245                 250                 255     


Glu Thr Lys Ile Cys Gln Glu 
            260             


<210>  295
<211>  3371
<212>  DNA
<213>  Homo sapiens

<400>  295
agcgggttcc attcccgggg gattggagta gcgttggagt caccgacgcc atcccctccc     60

gcctctggcg tagcaggagc atgcgcttcc ttcctcactt cctctccagg agggagcgag    120

agtaaagcta cgccctggcg cgcagtctcc gcgtcacagg aacttcagca cccacagggc    180

ggacagcgct cccctctacc tggagacttg actcccgcgc gccccaaccc tgcttatccc    240

ttgaccgtcg agtgtcagag atcctgcagc cgcccagtcc cggcccctct cccgccccac    300

acccaccctc ctggctcttc ctgtttttac tcctcctttt cattcataac aaaagctaca    360

gctccaggag cccagcgccg ggctgtgacc caagccgagc gtggaagaat ggggttcctc    420

gggaccggca cttggattct ggtgttagtg ctcccgattc aagctttccc caaacctgga    480

ggaagccaag acaaatctct acataataga gaattaagtg cagaaagacc tttgaatgaa    540

cagattgctg aagcagaaga agacaagatt aaaaaaacat atcctccaga aaacaagcca    600

ggtcagagca actattcttt tgttgataac ttgaacctgc taaaggcaat aacagaaaag    660

gaaaaaattg agaaagaaag acaatctata agaagctccc cacttgataa taagttgaat    720

gtggaagatg ttgattcaac caagaatcga aaactgatcg atgattatga ctctactaag    780

agtggattgg atcataaatt tcaagatgat ccagatggtc ttcatcaact agacgggact    840

cctttaaccg ctgaagacat tgtccataaa atcgctgcca ggatttatga agaaaatgac    900

agagccgtgt ttgacaagat tgtttctaaa ctacttaatc tcggccttat cacagaaagc    960

caagcacata cactggaaga tgaagtagca gaggttttac aaaaattaat ctcaaaggaa   1020

gccaacaatt atgaggagga tcccaataag cccacaagct ggactgagaa tcaggctgga   1080

aaaataccag agaaagtgac tccaatggca gcaattcaag atggtcttgc taagggagaa   1140

aacgatgaaa cagtatctaa cacattaacc ttgacaaatg gcttggaaag gagaactaaa   1200

acctacagtg aagacaactt tgaggaactc caatatttcc caaatttcta tgcgctactg   1260

aaaagtattg attcagaaaa agaagcaaaa gagaaagaaa cactgattac tatcatgaaa   1320

acactgattg actttgtgaa gatgatggtg aaatatggaa caatatctcc agaagaaggt   1380

gtttcctacc ttgaaaactt ggatgaaatg attgctcttc agaccaaaaa caagctagaa   1440

aaaaatgcta ctgacaatat aagcaagctt ttcccagcac catcagagaa gagtcatgaa   1500

gaaacagaca gtaccaagga agaagcagct aagatggaaa aggaatatgg aagcttgaag   1560

gattccacaa aagatgataa ctccaaccca ggaggaaaga cagatgaacc caaaggaaaa   1620

acagaagcct atttggaagc catcagaaaa aatattgaat ggttgaagaa acatgacaaa   1680

aagggaaata aagaagatta tgacctttca aagatgagag acttcatcaa taaacaagct   1740

gatgcttatg tggagaaagg catccttgac aaggaagaag ccgaggccat caagcgcatt   1800

tatagcagcc tgtaaaaatg gcaaaagatc caggagtctt tcaactgttt cagaaaacat   1860

aatatagctt aaaacacttc taattctgtg attaaaattt tttgacccaa gggttattag   1920

aaagtgctga atttacagta gttaaccttt tacaagtggt taaaacatag ctttcttccc   1980

gtaaaaacta tctgaaagta aagttgtatg taagctgaga ttttgtatac agaatcctta   2040

tttcctcata gacttatatt ttataatcag aatatgttgc tttgaaaaag cctctaatgg   2100

actgacctta aaactcatcc ttcttccact gtctcatcca cataagcact ccccgaagaa   2160

ttaagggggt tctgttttca aggcatgcca agtactaaag caccttgcag agcgtgtcta   2220

ttacaagatg tcatttccac cagcagttcc cttaggggag ctgaaataaa ttcacatttt   2280

ctcaaagtct catagctttg gaggagccat ctgctttttt ggctgctctt tttagctggc   2340

tttttattag gctcagtgac ataaaaagga tccaggtaaa tgggtatagg atttgctgga   2400

tttactaaca atttccccct gttcttaaca cttcctatta gtgacttttc agacattgag   2460

tttacttata aagagagata tttatgtact ctctaagaag acaaatgagg tcataaacac   2520

tgcataaagc aaggcaaaaa tgtatgccac atctcagtta tctaaactag attagatcca   2580

agccaagttt tctcaacaga gagcaaaggg ccaggcagta aggtagaaat agagataaaa   2640

atcattcctt ccttgtgatc caaagctggt cgagcagctt tcctggagga aaaggttaat   2700

gaacttcagg tccctgcaac tcagccccca ccacaaacac agccctggaa acatacagtg   2760

gcgcaaggtc ctcttgaaat gttaatggtt aatgttccca aaccagagaa tgctttgaaa   2820

atgtatcatt cagtgtaaat taattacata catatttttc tatatatttg tttcaaactg   2880

taaaaataac ataatatgta atttgtgtat tagtgagagg tgaagccagc tggacttcct   2940

gggtcgagtg gggccttgga gaacttttct gtcttacaag aggattgtaa aatgcaccca   3000

tcagtgctct gtaaaacaca ccaatcagcg ctctgtagct agcaataggt ttgtaaaatg   3060

cacccatcag cactctgtaa aacgcaccaa tcagcactct gtaaaatgca ccaatcagca   3120

ggattctaaa agtagacaat cacagggagg attgaaaaaa agggcactct gatagggcaa   3180

aaacggaaca tgggagggga caaataaggg aataaaatct ggccacccca gccagcagca   3240

gcaacctgtt caggtcgcct gccgctgtgg aagctttgtc cttttgctct tcataataaa   3300

ccttgctact gttcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3360

aaaaaaaaaa a                                                        3371


<210>  296
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Gly Phe Leu Gly Thr Gly Thr Trp Ile Leu Val Leu Val Leu Pro 
1               5                   10                  15      


Ile Gln Ala Phe Pro Lys Pro Gly Gly Ser Gln Asp Lys Ser Leu His 
            20                  25                  30          


Asn Arg Glu Leu Ser Ala Glu Arg Pro Leu Asn Glu Gln Ile Ala Glu 
        35                  40                  45              


Ala Glu Glu Asp Lys Ile Lys Lys Thr Tyr Pro Pro Glu Asn Lys Pro 
    50                  55                  60                  


Gly Gln Ser Asn Tyr Ser Phe Val Asp Asn Leu Asn Leu Leu Lys Ala 
65                  70                  75                  80  


Ile Thr Glu Lys Glu Lys Ile Glu Lys Glu Arg Gln Ser Ile Arg Ser 
                85                  90                  95      


Ser Pro Leu Asp Asn Lys Leu Asn Val Glu Asp Val Asp Ser Thr Lys 
            100                 105                 110         


Asn Arg Lys Leu Ile Asp Asp Tyr Asp Ser Thr Lys Ser Gly Leu Asp 
        115                 120                 125             


His Lys Phe Gln Asp Asp Pro Asp Gly Leu His Gln Leu Asp Gly Thr 
    130                 135                 140                 


Pro Leu Thr Ala Glu Asp Ile Val His Lys Ile Ala Ala Arg Ile Tyr 
145                 150                 155                 160 


Glu Glu Asn Asp Arg Ala Val Phe Asp Lys Ile Val Ser Lys Leu Leu 
                165                 170                 175     


Asn Leu Gly Leu Ile Thr Glu Ser Gln Ala His Thr Leu Glu Asp Glu 
            180                 185                 190         


Val Ala Glu Val Leu Gln Lys Leu Ile Ser Lys Glu Ala Asn Asn Tyr 
        195                 200                 205             


Glu Glu Asp Pro Asn Lys Pro Thr Ser Trp Thr Glu Asn Gln Ala Gly 
    210                 215                 220                 


Lys Ile Pro Glu Lys Val Thr Pro Met Ala Ala Ile Gln Asp Gly Leu 
225                 230                 235                 240 


Ala Lys Gly Glu Asn Asp Glu Thr Val Ser Asn Thr Leu Thr Leu Thr 
                245                 250                 255     


Asn Gly Leu Glu Arg Arg Thr Lys Thr Tyr Ser Glu Asp Asn Phe Glu 
            260                 265                 270         


Glu Leu Gln Tyr Phe Pro Asn Phe Tyr Ala Leu Leu Lys Ser Ile Asp 
        275                 280                 285             


Ser Glu Lys Glu Ala Lys Glu Lys Glu Thr Leu Ile Thr Ile Met Lys 
    290                 295                 300                 


Thr Leu Ile Asp Phe Val Lys Met Met Val Lys Tyr Gly Thr Ile Ser 
305                 310                 315                 320 


Pro Glu Glu Gly Val Ser Tyr Leu Glu Asn Leu Asp Glu Met Ile Ala 
                325                 330                 335     


Leu Gln Thr Lys Asn Lys Leu Glu Lys Asn Ala Thr Asp Asn Ile Ser 
            340                 345                 350         


Lys Leu Phe Pro Ala Pro Ser Glu Lys Ser His Glu Glu Thr Asp Ser 
        355                 360                 365             


Thr Lys Glu Glu Ala Ala Lys Met Glu Lys Glu Tyr Gly Ser Leu Lys 
    370                 375                 380                 


Asp Ser Thr Lys Asp Asp Asn Ser Asn Pro Gly Gly Lys Thr Asp Glu 
385                 390                 395                 400 


Pro Lys Gly Lys Thr Glu Ala Tyr Leu Glu Ala Ile Arg Lys Asn Ile 
                405                 410                 415     


Glu Trp Leu Lys Lys His Asp Lys Lys Gly Asn Lys Glu Asp Tyr Asp 
            420                 425                 430         


Leu Ser Lys Met Arg Asp Phe Ile Asn Lys Gln Ala Asp Ala Tyr Val 
        435                 440                 445             


Glu Lys Gly Ile Leu Asp Lys Glu Glu Ala Glu Ala Ile Lys Arg Ile 
    450                 455                 460                 


Tyr Ser Ser Leu 
465             


<210>  297
<211>  2494
<212>  DNA
<213>  Homo sapiens

<400>  297
cacgaggcag gggccatttt acctccaggt tggccctgct caggaccagg aggaaacacc     60

tccagcccgc gacctcctcc cacaggggga aaaggaaagc aggaggacca cagaagcttt    120

ggcaccgagg atccccgcag tcttcacccg cggagattcc ggctgaagga gctgtccagc    180

gactacaccg ctaagcgcag ggagcccaag cctccgcacc ggattccgga gcacaagctc    240

caccgcgcat gcgcacacgc cccagaccca ggctcaggag gactgagaat tttctgaccg    300

cagtgcacca tgggaagctc tgaagtttcc ataattcctg ggctccagaa agaagaaaag    360

gcggccgtgg agagacgaag acttcatgtg ctgaaagctc tgaagaagct aaggattgag    420

gctgatgagg ccccagttgt tgctgtgctg ggctcaggcg gaggactgcg ggctcacatt    480

gcctgccttg gggtcctgag tgagatgaaa gaacagggcc tgttggatgc cgtcacgtac    540

ctcgcagggg tctctggatc cacttgggca atatcttctc tctacaccaa tgatggtgac    600

atggaagctc tcgaggctga cctgaaacat cgatttaccc gacaggagtg ggacttggct    660

aagagcctac agaaaaccat ccaagcagcg aggtctgaga attactctct gaccgacttc    720

tgggcctaca tggttatctc taagcaaacc agagaactgc cggagtctca tttgtccaat    780

atgaagaagc ccgtggaaga agggacacta ccctacccaa tatttgcagc cattgacaat    840

gacctgcaac cttcctggca ggaggcaaga gcaccagaga cctggttcga gttcacccct    900

caccacgctg gcttctctgc actgggggcc tttgtttcca taacccactt cggaagcaaa    960

ttcaagaagg gaagactggt cagaactcac cctgagagag acctgacttt cctgagaggt   1020

ttatggggaa gtgctcttgg taacactgaa gtcattaggg aatacatttt tgaccagtta   1080

aggaatctga ccctgaaagg tttatggaga agggctgttg ctaatgctaa aagcattgga   1140

caccttattt ttgcccgatt actgaggctg caagaaagtt cacaagggga acatcctccc   1200

ccagaagatg aaggcggtga gcctgaacac acctggctga ctgagatgct cgagaattgg   1260

accaggacct ccctggaaaa gcaggagcag ccccatgagg accccgaaag gaaaggctca   1320

ctcagtaact tgatggattt tgtgaagaaa acaggcattt gcgcttcaaa gtgggaatgg   1380

gggaccactc acaacttcct gtacaaacac ggtggcatcc gggacaagat aatgagcagc   1440

cggaagcacc tccacctggt ggatgctggt ttagccatca acactccctt cccactcgtg   1500

ctgcccccga cgcgggaggt tcacctcatc ctctccttcg acttcagtgc cggagatcct   1560

ttcgagacca tccgggctac cactgactac tgccgccgcc acaagatccc ctttccccaa   1620

gtagaagagg ctgagctgga tttgtggtcc aaggcccccg ccagctgcta catcctgaaa   1680

ggagaaactg gaccagtggt gatacatttt cccctgttca acatagatgc ctgtggaggt   1740

gatattgagg catggagtga cacatacgac acattcaagc ttgctgacac ctacactcta   1800

gatgtggtgg tgctactctt ggcattagcc aagaagaatg tcagggaaaa caagaagaag   1860

atccttagag agttgatgaa cgtggccggg ctctactacc cgaaggatag tgcccgaagt   1920

tgctgcttgg catagatgag cctcagcttc cagggcactg tgggcctgtt ggtctactag   1980

ggccctgaag tccacctggc cttcctgttc ttcactccct tcagccacac gcttcatggc   2040

cttgagttca ccttggctgt cctaacaggg ccaatcacca gtgaccagct agactgtgat   2100

tttgatagcg tcattcagaa gaaggtgtcc aaggagctga aggtggtgaa atttgtcctg   2160

caggtccctc gggagatcct ggagctggag catgagtgtc tgacaatcag aagcatcatg   2220

tccaatgtcc agatggccag aatgaatgtg atagttcaga ccaatgcctt ccactgctcc   2280

tttatgactg cacttctagc cagtagctct gcacaagtta gctctgtaga agtaagaact   2340

tgggcttaaa tcatgggcta tctctccaca gccaagtgga gctctgagaa tacaacaagt   2400

gctcaataaa tgcttgctga ttgactgatg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2460

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                               2494


<210>  298
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Gly Ser Ser Glu Val Ser Ile Ile Pro Gly Leu Gln Lys Glu Glu 
1               5                   10                  15      


Lys Ala Ala Val Glu Arg Arg Arg Leu His Val Leu Lys Ala Leu Lys 
            20                  25                  30          


Lys Leu Arg Ile Glu Ala Asp Glu Ala Pro Val Val Ala Val Leu Gly 
        35                  40                  45              


Ser Gly Gly Gly Leu Arg Ala His Ile Ala Cys Leu Gly Val Leu Ser 
    50                  55                  60                  


Glu Met Lys Glu Gln Gly Leu Leu Asp Ala Val Thr Tyr Leu Ala Gly 
65                  70                  75                  80  


Val Ser Gly Ser Thr Trp Ala Ile Ser Ser Leu Tyr Thr Asn Asp Gly 
                85                  90                  95      


Asp Met Glu Ala Leu Glu Ala Asp Leu Lys His Arg Phe Thr Arg Gln 
            100                 105                 110         


Glu Trp Asp Leu Ala Lys Ser Leu Gln Lys Thr Ile Gln Ala Ala Arg 
        115                 120                 125             


Ser Glu Asn Tyr Ser Leu Thr Asp Phe Trp Ala Tyr Met Val Ile Ser 
    130                 135                 140                 


Lys Gln Thr Arg Glu Leu Pro Glu Ser His Leu Ser Asn Met Lys Lys 
145                 150                 155                 160 


Pro Val Glu Glu Gly Thr Leu Pro Tyr Pro Ile Phe Ala Ala Ile Asp 
                165                 170                 175     


Asn Asp Leu Gln Pro Ser Trp Gln Glu Ala Arg Ala Pro Glu Thr Trp 
            180                 185                 190         


Phe Glu Phe Thr Pro His His Ala Gly Phe Ser Ala Leu Gly Ala Phe 
        195                 200                 205             


Val Ser Ile Thr His Phe Gly Ser Lys Phe Lys Lys Gly Arg Leu Val 
    210                 215                 220                 


Arg Thr His Pro Glu Arg Asp Leu Thr Phe Leu Arg Gly Leu Trp Gly 
225                 230                 235                 240 


Ser Ala Leu Gly Asn Thr Glu Val Ile Arg Glu Tyr Ile Phe Asp Gln 
                245                 250                 255     


Leu Arg Asn Leu Thr Leu Lys Gly Leu Trp Arg Arg Ala Val Ala Asn 
            260                 265                 270         


Ala Lys Ser Ile Gly His Leu Ile Phe Ala Arg Leu Leu Arg Leu Gln 
        275                 280                 285             


Glu Ser Ser Gln Gly Glu His Pro Pro Pro Glu Asp Glu Gly Gly Glu 
    290                 295                 300                 


Pro Glu His Thr Trp Leu Thr Glu Met Leu Glu Asn Trp Thr Arg Thr 
305                 310                 315                 320 


Ser Leu Glu Lys Gln Glu Gln Pro His Glu Asp Pro Glu Arg Lys Gly 
                325                 330                 335     


Ser Leu Ser Asn Leu Met Asp Phe Val Lys Lys Thr Gly Ile Cys Ala 
            340                 345                 350         


Ser Lys Trp Glu Trp Gly Thr Thr His Asn Phe Leu Tyr Lys His Gly 
        355                 360                 365             


Gly Ile Arg Asp Lys Ile Met Ser Ser Arg Lys His Leu His Leu Val 
    370                 375                 380                 


Asp Ala Gly Leu Ala Ile Asn Thr Pro Phe Pro Leu Val Leu Pro Pro 
385                 390                 395                 400 


Thr Arg Glu Val His Leu Ile Leu Ser Phe Asp Phe Ser Ala Gly Asp 
                405                 410                 415     


Pro Phe Glu Thr Ile Arg Ala Thr Thr Asp Tyr Cys Arg Arg His Lys 
            420                 425                 430         


Ile Pro Phe Pro Gln Val Glu Glu Ala Glu Leu Asp Leu Trp Ser Lys 
        435                 440                 445             


Ala Pro Ala Ser Cys Tyr Ile Leu Lys Gly Glu Thr Gly Pro Val Val 
    450                 455                 460                 


Ile His Phe Pro Leu Phe Asn Ile Asp Ala Cys Gly Gly Asp Ile Glu 
465                 470                 475                 480 


Ala Trp Ser Asp Thr Tyr Asp Thr Phe Lys Leu Ala Asp Thr Tyr Thr 
                485                 490                 495     


Leu Asp Val Val Val Leu Leu Leu Ala Leu Ala Lys Lys Asn Val Arg 
            500                 505                 510         


Glu Asn Lys Lys Lys Ile Leu Arg Glu Leu Met Asn Val Ala Gly Leu 
        515                 520                 525             


Tyr Tyr Pro Lys Asp Ser Ala Arg Ser Cys Cys Leu Ala 
    530                 535                 540     


<210>  299
<211>  3097
<212>  DNA
<213>  Homo sapiens

<400>  299
cccccgaggg acatgagaga agaggagcgg cgctcaggtt attccaggat ctttggagac     60

ccgaggaaag ccgtgttgac caaaagcaag acaaatgact cacagagaaa aaagatggca    120

gaaccaaggg caactaaagc cgtcaggttc tgaacagctg gtagatgggc tggcttactg    180

aaggacatga ttcagactgt cccggaccca gcagctcata tcaaggaagc cttatcagtt    240

gtgagtgagg accagtcgtt gtttgagtgt gcctacggaa cgccacacct ggctaagaca    300

gagatgaccg cgtcctcctc cagcgactat ggacagactt ccaagatgag cccacgcgtc    360

cctcagcagg attggctgtc tcaaccccca gccagggtca ccatcaaaat ggaatgtaac    420

cctagccagg tgaatggctc aaggaactct cctgatgaat gcagtgtggc caaaggcggg    480

aagatggtgg gcagcccaga caccgttggg atgaactacg gcagctacat ggaggagaag    540

cacatgccac ccccaaacat gaccacgaac gagcgcagag ttatcgtgcc agcagatcct    600

acgctatgga gtacagacca tgtgcggcag tggctggagt gggcggtgaa agaatatggc    660

cttccagacg tcaacatctt gttattccag aacatcgatg ggaaggaact gtgcaagatg    720

accaaggacg acttccagag gctcaccccc agctacaacg ccgacatcct tctctcacat    780

ctccactacc tcagagagac tcctcttcca catttgactt cagatgatgt tgataaagcc    840

ttacaaaact ctccacggtt aatgcatgct agaaacacag atttaccata tgagcccccc    900

aggagatcag cctggaccgg tcacggccac cccacgcccc agtcgaaagc tgctcaacca    960

tctccttcca cagtgcccaa aactgaagac cagcgtcctc agttagatcc ttatcagatt   1020

cttggaccaa caagtagccg ccttgcaaat ccaggcagtg gccagatcca gctttggcag   1080

ttcctcctgg agctcctgtc ggacagctcc aactccagct gcatcacctg ggaaggcacc   1140

aacggggagt tcaagatgac ggatcccgac gaggtggccc ggcgctgggg agagcggaag   1200

agcaaaccca acatgaacta cgataagctc agccgcgccc tccgttacta ctatgacaag   1260

aacatcatga ccaaggtcca tgggaagcgc tacgcctaca agttcgactt ccacgggatc   1320

gcccaggccc tccagcccca ccccccggag tcatctctgt acaagtaccc ctcagacctc   1380

ccgtacatgg gctcctatca cgcccaccca cagaagatga actttgtggc gccccaccct   1440

ccagccctcc ccgtgacatc ttccagtttt tttgctgccc caaacccata ctggaattca   1500

ccaactgggg gtatataccc caacactagg ctccccacca gccatatgcc ttctcatctg   1560

ggcacttact actaaagacc tggcggaggc ttttcccatc agcgtgcatt caccagccca   1620

tcgccacaaa ctctatcgga gaacatgaat caaaagtgcc tcaagaggaa tgaaaaaagc   1680

tttactgggg ctggggaagg aagccgggga agagatccaa agactcttgg gagggagtta   1740

ctgaagtctt actacagaaa tgaggaggat gctaaaaatg tcacgaatat ggacatatca   1800

tctgtggact gaccttgtaa aagacagtgt atgtagaagc atgaagtctt aaggacaaag   1860

tgccaaagaa agtggtctta agaaatgtat aaactttaga gtagagtttg gaatcccact   1920

aatgcaaact gggatgaaac taaagcaata gaaacaacac agttttgacc taacataccg   1980

tttataatgc cattttaagg aaaactacct gtatttaaaa atagaaacat atcaaaaaca   2040

agagaaaaga cacgagagag actgtggccc atcaacagac gttgatatgc aactgcatgg   2100

catgtgctgt tttggttgaa atcaaataca ttccgtttga tggacagctg tcagctttct   2160

caaactgtga agatgaccca aagtttccaa ctcctttaca gtattaccgg gactatgaac   2220

taaaaggtgg gactgaggat gtgtatagag tgagcgtgtg attgtagaca gaggggtgaa   2280

gaaggaggag gaagaggcag agaaggagga gaccaggctg ggaaagaaac ttctcaagca   2340

atgaagactg gactcaggac atttggggac tgtgtacaat gagttatgga gactcgaggg   2400

ttcatgcagt cagtgttata ccaaacccag tgttaggaga aaggacacag cgtaatggag   2460

aaagggaagt agtagaattc agaaacaaaa atgcgcatct ctttctttgt ttgtcaaatg   2520

aaaattttaa ctggaattgt ctgatattta agagaaacat tcaggacctc atcattatgt   2580

gggggctttg ttctccacag ggtcaggtaa gagatggcct tcttggctgc cacaatcaga   2640

aatcacgcag gcattttggg taggcggcct ccagttttcc tttgagtcgc gaacgctgtg   2700

cgtttgtcag aatgaagtat acaagtcaat gtttttcccc ctttttatat aataattata   2760

taacttatgc atttatacac tacgagttga tctcggccag ccaaagacac acgacaaaag   2820

agacaatcga tataatgtgg ccttgaattt taactctgta tgcttaatgt ttacaatatg   2880

aagttattag ttcttagaat gcagaatgta tgtaataaaa taagcttggc ctagcatggc   2940

aaatcagatt tatacaggag tctgcatttg cacttttttt agtgactaaa gttgcttaat   3000

gaaaacatgt gctgaatgtt gtggattttg tgttataatt tactttgtcc aggaacttgt   3060

gcaagggaga gccaaggaaa taggatgttt ggcaccc                            3097


<210>  300
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Ile Gln Thr Val Pro Asp Pro Ala Ala His Ile Lys Glu Ala Leu 
1               5                   10                  15      


Ser Val Val Ser Glu Asp Gln Ser Leu Phe Glu Cys Ala Tyr Gly Thr 
            20                  25                  30          


Pro His Leu Ala Lys Thr Glu Met Thr Ala Ser Ser Ser Ser Asp Tyr 
        35                  40                  45              


Gly Gln Thr Ser Lys Met Ser Pro Arg Val Pro Gln Gln Asp Trp Leu 
    50                  55                  60                  


Ser Gln Pro Pro Ala Arg Val Thr Ile Lys Met Glu Cys Asn Pro Ser 
65                  70                  75                  80  


Gln Val Asn Gly Ser Arg Asn Ser Pro Asp Glu Cys Ser Val Ala Lys 
                85                  90                  95      


Gly Gly Lys Met Val Gly Ser Pro Asp Thr Val Gly Met Asn Tyr Gly 
            100                 105                 110         


Ser Tyr Met Glu Glu Lys His Met Pro Pro Pro Asn Met Thr Thr Asn 
        115                 120                 125             


Glu Arg Arg Val Ile Val Pro Ala Asp Pro Thr Leu Trp Ser Thr Asp 
    130                 135                 140                 


His Val Arg Gln Trp Leu Glu Trp Ala Val Lys Glu Tyr Gly Leu Pro 
145                 150                 155                 160 


Asp Val Asn Ile Leu Leu Phe Gln Asn Ile Asp Gly Lys Glu Leu Cys 
                165                 170                 175     


Lys Met Thr Lys Asp Asp Phe Gln Arg Leu Thr Pro Ser Tyr Asn Ala 
            180                 185                 190         


Asp Ile Leu Leu Ser His Leu His Tyr Leu Arg Glu Thr Pro Leu Pro 
        195                 200                 205             


His Leu Thr Ser Asp Asp Val Asp Lys Ala Leu Gln Asn Ser Pro Arg 
    210                 215                 220                 


Leu Met His Ala Arg Asn Thr Asp Leu Pro Tyr Glu Pro Pro Arg Arg 
225                 230                 235                 240 


Ser Ala Trp Thr Gly His Gly His Pro Thr Pro Gln Ser Lys Ala Ala 
                245                 250                 255     


Gln Pro Ser Pro Ser Thr Val Pro Lys Thr Glu Asp Gln Arg Pro Gln 
            260                 265                 270         


Leu Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala Asn 
        275                 280                 285             


Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu 
    290                 295                 300                 


Ser Asp Ser Ser Asn Ser Ser Cys Ile Thr Trp Glu Gly Thr Asn Gly 
305                 310                 315                 320 


Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly Glu 
                325                 330                 335     


Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu 
            340                 345                 350         


Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys Arg 
        355                 360                 365             


Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln Pro 
    370                 375                 380                 


His Pro Pro Glu Ser Ser Leu Tyr Lys Tyr Pro Ser Asp Leu Pro Tyr 
385                 390                 395                 400 


Met Gly Ser Tyr His Ala His Pro Gln Lys Met Asn Phe Val Ala Pro 
                405                 410                 415     


His Pro Pro Ala Leu Pro Val Thr Ser Ser Ser Phe Phe Ala Ala Pro 
            420                 425                 430         


Asn Pro Tyr Trp Asn Ser Pro Thr Gly Gly Ile Tyr Pro Asn Thr Arg 
        435                 440                 445             


Leu Pro Thr Ser His Met Pro Ser His Leu Gly Thr Tyr Tyr 
    450                 455                 460         


<210>  301
<211>  4510
<212>  DNA
<213>  Homo sapiens

<400>  301
gctgaggcca ggagggcgca ctggggattg gaggcgaggg aagtgcaggg cgcatcccag     60

gcggcagggc tcccagcatc ggcagtcgcc atcaccgcca gaccgcagag acaggttcgg    120

atccgcggtc ctcttgcctc tttccaggcc tcgatgagtg ttaaatcgcc atttaatgtg    180

atgtcaagaa ataatttgga agcacctcct tgtaagatga cagagccatt taattttgag    240

aaaaatgaaa acaagcttcc accacatgag tctttaagaa gtcctggaac acttcctaac    300

caccctaatt tcaggctgaa aagctcagag aatggaaata aaaagaacaa ttttttgctt    360

tgtgagcaaa ccaaacaata tttggctagt caggaagaca attcagtttc ttcaaacccg    420

aatggcatca acggagaagt agttggctcc aaaggagaca ggaaaaaatt gccagcagga    480

aactcagtgt caccaccaag tgctgaaagt aattcaccac ccaaagaagt gaatattaag    540

cctggaaata atgtacgtcc tgcaaaatca aaaaaactaa acaagttggt cgagaattcc    600

ttgtccataa gtaatccagg gctcttcacc tccttaggac ctcctcttcg gtccacaact    660

tgccatcgct gtggcctatt tggatcgctg aggtgctctc agtgcaagca gacctactat    720

tgctccacag catgtcaaag aagagactgg tctgcacaca gcatcgtgtg caggcctgtt    780

cagccaaatt tccacaaact tgaaaataaa tcatctattg aaacaaagga tgtggaggta    840

aacaataaga gtgactgtcc acttggagtt actaaggaaa tagccatttg ggctgagaga    900

ataatgtttt ctgatttgag aagtctacaa ctcaagaaaa ccatggaaat aaagggtacg    960

gttaccgaat tcaaacaccc aggggacttc tacgtgcagt tatattcttc agaagtttta   1020

gaatacatga accaactctc tgccagctta aaagaaacat atgcaaatgt gcatgaaaaa   1080

gactatattc ctgttaaggg ggaagtttgt attgccaagt acactgttga tcagacctgg   1140

aacagagcaa tcatacaaaa cgttgatgtg cagcaaaaga aggcacatgt cttatatatt   1200

gattatggaa atgaagaaat aattccatta aacagaattt accacctcaa caggaacatt   1260

gacttgtttc ctccttgtgc cataaagtgc tttgtagcca atgttatccc agcagaaggg   1320

aattggagca gtgattgtat caaagctact aaaccactgt taatggagca gtactgctcc   1380

ataaagattg tcgacatctt ggaagaggaa gtggttacct ttgctgtaga agttgagctg   1440

ccaaattcag gaaaactttt agaccatgtg cttatagaaa tgggatatgg cttgaaaccc   1500

agtggacaag attctaagaa ggaaaatgca gatcaaagtg atcctgaaga tgttggaaaa   1560

atgacaactg aaaacaacat tgtcgtagac aaaagtgacc taatcccaaa agtgttaact   1620

ttgaatgtag gtgatgagtt ttgtggtgtg gttgcccaca ttcaaacacc agaagacttc   1680

ttttgtcaac aactgcaaag tggccgaaag cttgctgaac ttcaggcatc ccttagcaag   1740

tactgtgatc agttgcctcc acgctctgat ttttatccag ccattggtga tatatgttgt   1800

gctcagttct cagaggatga tcagtggtac cgtgcctctg ttttggctta cgcttctgaa   1860

gaatctgtac tggtcggata tgtagattat ggaaactttg aaatccttag tttgatgaga   1920

ctttgtccca taatcccaaa gttgttggaa ttgccaatgc aagctataaa gtgtgtacta   1980

gcaggagtaa agccatcatt aggaatttgg actccagaag ctatttgtct catgaaaaaa   2040

cttgtacaga acaaaataat cacagtgaaa gtggtggaca agttggaaaa cagttccctg   2100

gtggagctta ttgataaatc cgagacgcct catgtcagtg ttagcaaagt tctcctagat   2160

gcaggctttg ctgtgggaga acagagtatg gtgacagata aacccagtga cgtgaaagaa   2220

accagtgttc ccttgggtgt ggaaggaaaa gtaaatccat tggagtggac atgggttgaa   2280

cttggtgttg accaaacagt agatgttgtg gtctgtgtga tatatagtcc tggagaattt   2340

tattgccatg tgcttaaaga ggatgcttta aagaaactca atgatttgaa caagtcatta   2400

gcagaacact gccagcagaa gttacctaat ggtttcaagg cagagatagg acaaccttgt   2460

tgtgcttttt ttgcaggtga tggtagttgg tatcgtgctt tagtcaagga aatcttacca   2520

aatggacatg ttaaagtaca ttttgtggat tatggaaaca tcgaagaagt tactgcagat   2580

gaactccgaa tgatatcatc aacattttta aaccttccct ttcagggaat acggtgccag   2640

ttagcagata tacagtctag aaacaaacat tggtctgaag aagccataac aagattccag   2700

atgtgtgttg ctgggataaa attgcaagcc agagtggttg aagtcactga aaatgggata   2760

ggagttgaac tcaccgatct ctccacttgt tatcccagaa taattagtga tgttctgatt   2820

gatgaacatc tggttttaaa atctgcttca ccacataaag acttaccaaa tgacagactt   2880

gttaataaac atgagcttca agttcatgta cagggacttc aagctacctc ttcagctgag   2940

caatggaaga cgatagaatt gccagtggat aaaactatac aagcaaatgt attagaaatc   3000

ataagcccaa acttgtttta tgctctacca aaagggatgc cagaaaatca ggaaaagctg   3060

tgcatgttga cagctgaatt attagaatac tgcaatgctc cgaaaagtcg accaccctat   3120

agaccaagaa ttggagacgc atgctgtgcc aaatacacaa gtgatgattt ttggtatcgt   3180

gcagttgttc tggggacatc agacactgat gtggaagtgc tctatgcaga ctatggaaac   3240

attgaaaccc tgcctctttg cagagtgcaa ccaatcacct ctagccacct ggcgcttcct   3300

ttccaaatta ttagatgttc acttgaagga ttaatggaat tgaatggaag ctcttctcaa   3360

ttaataataa tgctattaaa aaatttcatg ttgaatcaga atgtaatgct ttctgtgaaa   3420

ggaattacaa agaatgtcca tacagtgtca gttgagaaat gttctgagaa tgggactgtc   3480

gatgtagctg ataagctagt gacatttggt ctggcaaaaa acatcacacc tcaaaggcag   3540

agtgctttaa atacagaaaa gatgtatagg atgaattgct gctgcacaga gttacagaaa   3600

caagttgaaa aacatgaaca tattcttctc ttcctcttaa acaattcaac caatcaaaat   3660

aaatttattg aaatgaaaaa actgttaaaa aaaacagcat ctcttggagg taaaccctta   3720

tgagacagga aacagcaaag gctagcttta ggagagaaag tacagcacct ggtgttttta   3780

tttatgagaa ccttttcttt gtccactttc tctgtaatga ccttctatcc ctccgttttt   3840

gcctgcctgc cattctccta ttaggttggt ggtttttatt ttcctctaag ttccttccac   3900

caaataaata ttacgtaaaa aattcatacc aaatcaatga gaatactggc aaggaataca   3960

tagggacttt ctgctatata tgtaactttt tattacttaa aggtaccgaa ggaaggccag   4020

gtgcagtggc tcacgcccag cactttggga ggctgaggtg ggaggatccc ttgaggccag   4080

gagttcaagg ttacagtgag ctatgatagt gccactgcac tccagcctgg gtgacagatt   4140

ttgtcttaaa aaaaaaaaaa aaaaagttga tatgagtttt attttctgtc cgtttgaaat   4200

attttgtaat attccctgca ttctctgtcg tctgcctctt ccacataatg tcctttgctt   4260

tcatgtttgt tatcttcttt ttctgttcac tcagaggtca tcaatttctt tctctccgtc   4320

cttaattgga ttatttttct tttggccttt gggcacagag tctgacctct ggaccactct   4380

aactggagaa ggaactttat gttccctctc ctgctgtgtc cacaacctta gaaatctgta   4440

gctagatttt tgttgttata gatagaattt actgtttctg aaacccaaat acagttatca   4500

gtttaaggtt                                                          4510


<210>  302
<211>  1189
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Ser Val Lys Ser Pro Phe Asn Val Met Ser Arg Asn Asn Leu Glu 
1               5                   10                  15      


Ala Pro Pro Cys Lys Met Thr Glu Pro Phe Asn Phe Glu Lys Asn Glu 
            20                  25                  30          


Asn Lys Leu Pro Pro His Glu Ser Leu Arg Ser Pro Gly Thr Leu Pro 
        35                  40                  45              


Asn His Pro Asn Phe Arg Leu Lys Ser Ser Glu Asn Gly Asn Lys Lys 
    50                  55                  60                  


Asn Asn Phe Leu Leu Cys Glu Gln Thr Lys Gln Tyr Leu Ala Ser Gln 
65                  70                  75                  80  


Glu Asp Asn Ser Val Ser Ser Asn Pro Asn Gly Ile Asn Gly Glu Val 
                85                  90                  95      


Val Gly Ser Lys Gly Asp Arg Lys Lys Leu Pro Ala Gly Asn Ser Val 
            100                 105                 110         


Ser Pro Pro Ser Ala Glu Ser Asn Ser Pro Pro Lys Glu Val Asn Ile 
        115                 120                 125             


Lys Pro Gly Asn Asn Val Arg Pro Ala Lys Ser Lys Lys Leu Asn Lys 
    130                 135                 140                 


Leu Val Glu Asn Ser Leu Ser Ile Ser Asn Pro Gly Leu Phe Thr Ser 
145                 150                 155                 160 


Leu Gly Pro Pro Leu Arg Ser Thr Thr Cys His Arg Cys Gly Leu Phe 
                165                 170                 175     


Gly Ser Leu Arg Cys Ser Gln Cys Lys Gln Thr Tyr Tyr Cys Ser Thr 
            180                 185                 190         


Ala Cys Gln Arg Arg Asp Trp Ser Ala His Ser Ile Val Cys Arg Pro 
        195                 200                 205             


Val Gln Pro Asn Phe His Lys Leu Glu Asn Lys Ser Ser Ile Glu Thr 
    210                 215                 220                 


Lys Asp Val Glu Val Asn Asn Lys Ser Asp Cys Pro Leu Gly Val Thr 
225                 230                 235                 240 


Lys Glu Ile Ala Ile Trp Ala Glu Arg Ile Met Phe Ser Asp Leu Arg 
                245                 250                 255     


Ser Leu Gln Leu Lys Lys Thr Met Glu Ile Lys Gly Thr Val Thr Glu 
            260                 265                 270         


Phe Lys His Pro Gly Asp Phe Tyr Val Gln Leu Tyr Ser Ser Glu Val 
        275                 280                 285             


Leu Glu Tyr Met Asn Gln Leu Ser Ala Ser Leu Lys Glu Thr Tyr Ala 
    290                 295                 300                 


Asn Val His Glu Lys Asp Tyr Ile Pro Val Lys Gly Glu Val Cys Ile 
305                 310                 315                 320 


Ala Lys Tyr Thr Val Asp Gln Thr Trp Asn Arg Ala Ile Ile Gln Asn 
                325                 330                 335     


Val Asp Val Gln Gln Lys Lys Ala His Val Leu Tyr Ile Asp Tyr Gly 
            340                 345                 350         


Asn Glu Glu Ile Ile Pro Leu Asn Arg Ile Tyr His Leu Asn Arg Asn 
        355                 360                 365             


Ile Asp Leu Phe Pro Pro Cys Ala Ile Lys Cys Phe Val Ala Asn Val 
    370                 375                 380                 


Ile Pro Ala Glu Gly Asn Trp Ser Ser Asp Cys Ile Lys Ala Thr Lys 
385                 390                 395                 400 


Pro Leu Leu Met Glu Gln Tyr Cys Ser Ile Lys Ile Val Asp Ile Leu 
                405                 410                 415     


Glu Glu Glu Val Val Thr Phe Ala Val Glu Val Glu Leu Pro Asn Ser 
            420                 425                 430         


Gly Lys Leu Leu Asp His Val Leu Ile Glu Met Gly Tyr Gly Leu Lys 
        435                 440                 445             


Pro Ser Gly Gln Asp Ser Lys Lys Glu Asn Ala Asp Gln Ser Asp Pro 
    450                 455                 460                 


Glu Asp Val Gly Lys Met Thr Thr Glu Asn Asn Ile Val Val Asp Lys 
465                 470                 475                 480 


Ser Asp Leu Ile Pro Lys Val Leu Thr Leu Asn Val Gly Asp Glu Phe 
                485                 490                 495     


Cys Gly Val Val Ala His Ile Gln Thr Pro Glu Asp Phe Phe Cys Gln 
            500                 505                 510         


Gln Leu Gln Ser Gly Arg Lys Leu Ala Glu Leu Gln Ala Ser Leu Ser 
        515                 520                 525             


Lys Tyr Cys Asp Gln Leu Pro Pro Arg Ser Asp Phe Tyr Pro Ala Ile 
    530                 535                 540                 


Gly Asp Ile Cys Cys Ala Gln Phe Ser Glu Asp Asp Gln Trp Tyr Arg 
545                 550                 555                 560 


Ala Ser Val Leu Ala Tyr Ala Ser Glu Glu Ser Val Leu Val Gly Tyr 
                565                 570                 575     


Val Asp Tyr Gly Asn Phe Glu Ile Leu Ser Leu Met Arg Leu Cys Pro 
            580                 585                 590         


Ile Ile Pro Lys Leu Leu Glu Leu Pro Met Gln Ala Ile Lys Cys Val 
        595                 600                 605             


Leu Ala Gly Val Lys Pro Ser Leu Gly Ile Trp Thr Pro Glu Ala Ile 
    610                 615                 620                 


Cys Leu Met Lys Lys Leu Val Gln Asn Lys Ile Ile Thr Val Lys Val 
625                 630                 635                 640 


Val Asp Lys Leu Glu Asn Ser Ser Leu Val Glu Leu Ile Asp Lys Ser 
                645                 650                 655     


Glu Thr Pro His Val Ser Val Ser Lys Val Leu Leu Asp Ala Gly Phe 
            660                 665                 670         


Ala Val Gly Glu Gln Ser Met Val Thr Asp Lys Pro Ser Asp Val Lys 
        675                 680                 685             


Glu Thr Ser Val Pro Leu Gly Val Glu Gly Lys Val Asn Pro Leu Glu 
    690                 695                 700                 


Trp Thr Trp Val Glu Leu Gly Val Asp Gln Thr Val Asp Val Val Val 
705                 710                 715                 720 


Cys Val Ile Tyr Ser Pro Gly Glu Phe Tyr Cys His Val Leu Lys Glu 
                725                 730                 735     


Asp Ala Leu Lys Lys Leu Asn Asp Leu Asn Lys Ser Leu Ala Glu His 
            740                 745                 750         


Cys Gln Gln Lys Leu Pro Asn Gly Phe Lys Ala Glu Ile Gly Gln Pro 
        755                 760                 765             


Cys Cys Ala Phe Phe Ala Gly Asp Gly Ser Trp Tyr Arg Ala Leu Val 
    770                 775                 780                 


Lys Glu Ile Leu Pro Asn Gly His Val Lys Val His Phe Val Asp Tyr 
785                 790                 795                 800 


Gly Asn Ile Glu Glu Val Thr Ala Asp Glu Leu Arg Met Ile Ser Ser 
                805                 810                 815     


Thr Phe Leu Asn Leu Pro Phe Gln Gly Ile Arg Cys Gln Leu Ala Asp 
            820                 825                 830         


Ile Gln Ser Arg Asn Lys His Trp Ser Glu Glu Ala Ile Thr Arg Phe 
        835                 840                 845             


Gln Met Cys Val Ala Gly Ile Lys Leu Gln Ala Arg Val Val Glu Val 
    850                 855                 860                 


Thr Glu Asn Gly Ile Gly Val Glu Leu Thr Asp Leu Ser Thr Cys Tyr 
865                 870                 875                 880 


Pro Arg Ile Ile Ser Asp Val Leu Ile Asp Glu His Leu Val Leu Lys 
                885                 890                 895     


Ser Ala Ser Pro His Lys Asp Leu Pro Asn Asp Arg Leu Val Asn Lys 
            900                 905                 910         


His Glu Leu Gln Val His Val Gln Gly Leu Gln Ala Thr Ser Ser Ala 
        915                 920                 925             


Glu Gln Trp Lys Thr Ile Glu Leu Pro Val Asp Lys Thr Ile Gln Ala 
    930                 935                 940                 


Asn Val Leu Glu Ile Ile Ser Pro Asn Leu Phe Tyr Ala Leu Pro Lys 
945                 950                 955                 960 


Gly Met Pro Glu Asn Gln Glu Lys Leu Cys Met Leu Thr Ala Glu Leu 
                965                 970                 975     


Leu Glu Tyr Cys Asn Ala Pro Lys Ser Arg Pro Pro Tyr Arg Pro Arg 
            980                 985                 990         


Ile Gly Asp Ala Cys Cys Ala Lys  Tyr Thr Ser Asp Asp  Phe Trp Tyr 
        995                 1000                 1005             


Arg Ala  Val Val Leu Gly Thr  Ser Asp Thr Asp Val  Glu Val Leu 
    1010                 1015                 1020             


Tyr Ala  Asp Tyr Gly Asn Ile  Glu Thr Leu Pro Leu  Cys Arg Val 
    1025                 1030                 1035             


Gln Pro  Ile Thr Ser Ser His  Leu Ala Leu Pro Phe  Gln Ile Ile 
    1040                 1045                 1050             


Arg Cys  Ser Leu Glu Gly Leu  Met Glu Leu Asn Gly  Ser Ser Ser 
    1055                 1060                 1065             


Gln Leu  Ile Ile Met Leu Leu  Lys Asn Phe Met Leu  Asn Gln Asn 
    1070                 1075                 1080             


Val Met  Leu Ser Val Lys Gly  Ile Thr Lys Asn Val  His Thr Val 
    1085                 1090                 1095             


Ser Val  Glu Lys Cys Ser Glu  Asn Gly Thr Val Asp  Val Ala Asp 
    1100                 1105                 1110             


Lys Leu  Val Thr Phe Gly Leu  Ala Lys Asn Ile Thr  Pro Gln Arg 
    1115                 1120                 1125             


Gln Ser  Ala Leu Asn Thr Glu  Lys Met Tyr Arg Met  Asn Cys Cys 
    1130                 1135                 1140             


Cys Thr  Glu Leu Gln Lys Gln  Val Glu Lys His Glu  His Ile Leu 
    1145                 1150                 1155             


Leu Phe  Leu Leu Asn Asn Ser  Thr Asn Gln Asn Lys  Phe Ile Glu 
    1160                 1165                 1170             


Met Lys  Lys Leu Leu Lys Lys  Thr Ala Ser Leu Gly  Gly Lys Pro 
    1175                 1180                 1185             


Leu 
    


<210>  303
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  303
cacagugcau acggggcuct t                                               21


<210>  304
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  304
cuccacggug aagguguagt t                                               21


<210>  305
<211>  2158
<212>  DNA
<213>  Homo sapiens

<400>  305
cggattgtca gactgctcct ccctcttctt tagactgcca cgaggaaaaa gcagatgtga     60

gaactcaagg ttcagggctg ctcttctaag aaacaagtct gccataatct ccatctgtgt    120

tggaatctgt taactaatga actggtctct gtgcaaatcc tgagtgctaa agcttccaac    180

aagactgatg ctagctcgtg tcaccaggaa gatgctacgt catgccaagt gttttcagcg    240

cctagcaatt tttggttctg tgagggcact gcataaagat aatagaacag caacccctca    300

gaatttctcc aactatgaat ccatgaaaca ggacttcaaa ctggggattc cagagtattt    360

caactttgct aaagatgtcc tggaccaatg gactgataag gaaaaggctg gaaagaaacc    420

ttcaaatcca gccttctggt ggatcaacag aaatggagaa gagatgcgat ggagttttga    480

ggaactggga tctctgtcca gaaaatttgc caatatactt tcagaagcct gttccctaca    540

aagaggagat cgggtaattc tgattctgcc cagggtccca gagtggtggc ttgcaaatgt    600

ggcctgtctg cgaacaggga cagttttaat tccaggaacc actcagctga cccagaaaga    660

cattctctac agactacaat cttcaaaagc aaactgcatt atcaccaatg atgttttagc    720

cccagcagta gacgctgttg catccaaatg tgaaaatctg cactccaagc tgattgtatc    780

agagaactcc agagaggggt gggggaacct caaggagttg atgaaacatg ccagtgacag    840

ccacacctgt gtgaagacaa aacacaatga gatcatggcc atattcttta ccagtggaac    900

aagtggatat ccgaaaatga ctgcacacac ccacagcagt tttggtttag gattatctgt    960

aaatggaagg ttctggctag atttgacacc ctcagatgtg atgtggaata cctcagatac   1020

gggctgggca aagtctgcat ggagtagtgt tttttctccg tggatccagg gagcatgtgt   1080

attcacacac catttacccc gttttgagcc gacttctatc ttgcaaacac tctccaagta   1140

ccccatcaca gtcttctgtt cagcaccaac tgtataccga atgcttgtac agaatgatat   1200

aaccagctat aagtttaaaa gcttaaagca ctgtgtgagt gctggggaac caattacccc   1260

tgacgtgact gaaaaatgga gaaacaagac gggcctggat atctacgaag gatatggaca   1320

gactgaaacg gtgctaatct gtggaaattt taagggaatg aaaattaaac ctggctcaat   1380

gggaaaacct tctcctgctt tcgatgttaa gattgtagat gtaaatggca atgttctacc   1440

tcctggacaa gaaggagata ttggcattca agttctaccc aaccgaccat ttggcctttt   1500

tactcattac gtagataatc cttcaaaaac agcttcaact ctacgaggca atttctatat   1560

cactggggac agaggatata tggataaaga tgggtatttc tggtttgttg caagagcaga   1620

tgatgtcata ttatcctctg gctatcgaat tggaccattt gaggtagaaa atgccctgaa   1680

tgaacaccct tcagttgcag agtcagctgt tgtcagcagc ccagacccca tcagaggaga   1740

ggtagtaaag gcttttgtcg ttctaaatcc tgattacaag tcacatgatc aagaacaact   1800

aataaaggag attcaggagc atgttaaaaa aactacagca ccttacaaat atcccagaaa   1860

ggtagaattt attcaagagc tgccaaagac tatcagtggg aagacaaaaa gaaatgaact   1920

gaggaagaaa gaatggaaga caatttaaag ttgtttcatt aattaccata tctataaaac   1980

aaacatagta tctgtcaatc tctagaaacc acaagatgat ggagaggtca taaaaactgt   2040

ggtagtatgc ttagaaactg ttgatttaaa atatcttgtg gttatgatat cagaggctaa   2100

attttgaaat aaaatatttg gcaaattcct ccaaaaaaaa aaaaaaaaaa aaaaaaaa     2158


<210>  306
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Leu Ala Arg Val Thr Arg Lys Met Leu Arg His Ala Lys Cys Phe 
1               5                   10                  15      


Gln Arg Leu Ala Ile Phe Gly Ser Val Arg Ala Leu His Lys Asp Asn 
            20                  25                  30          


Arg Thr Ala Thr Pro Gln Asn Phe Ser Asn Tyr Glu Ser Met Lys Gln 
        35                  40                  45              


Asp Phe Lys Leu Gly Ile Pro Glu Tyr Phe Asn Phe Ala Lys Asp Val 
    50                  55                  60                  


Leu Asp Gln Trp Thr Asp Lys Glu Lys Ala Gly Lys Lys Pro Ser Asn 
65                  70                  75                  80  


Pro Ala Phe Trp Trp Ile Asn Arg Asn Gly Glu Glu Met Arg Trp Ser 
                85                  90                  95      


Phe Glu Glu Leu Gly Ser Leu Ser Arg Lys Phe Ala Asn Ile Leu Ser 
            100                 105                 110         


Glu Ala Cys Ser Leu Gln Arg Gly Asp Arg Val Ile Leu Ile Leu Pro 
        115                 120                 125             


Arg Val Pro Glu Trp Trp Leu Ala Asn Val Ala Cys Leu Arg Thr Gly 
    130                 135                 140                 


Thr Val Leu Ile Pro Gly Thr Thr Gln Leu Thr Gln Lys Asp Ile Leu 
145                 150                 155                 160 


Tyr Arg Leu Gln Ser Ser Lys Ala Asn Cys Ile Ile Thr Asn Asp Val 
                165                 170                 175     


Leu Ala Pro Ala Val Asp Ala Val Ala Ser Lys Cys Glu Asn Leu His 
            180                 185                 190         


Ser Lys Leu Ile Val Ser Glu Asn Ser Arg Glu Gly Trp Gly Asn Leu 
        195                 200                 205             


Lys Glu Leu Met Lys His Ala Ser Asp Ser His Thr Cys Val Lys Thr 
    210                 215                 220                 


Lys His Asn Glu Ile Met Ala Ile Phe Phe Thr Ser Gly Thr Ser Gly 
225                 230                 235                 240 


Tyr Pro Lys Met Thr Ala His Thr His Ser Ser Phe Gly Leu Gly Leu 
                245                 250                 255     


Ser Val Asn Gly Arg Phe Trp Leu Asp Leu Thr Pro Ser Asp Val Met 
            260                 265                 270         


Trp Asn Thr Ser Asp Thr Gly Trp Ala Lys Ser Ala Trp Ser Ser Val 
        275                 280                 285             


Phe Ser Pro Trp Ile Gln Gly Ala Cys Val Phe Thr His His Leu Pro 
    290                 295                 300                 


Arg Phe Glu Pro Thr Ser Ile Leu Gln Thr Leu Ser Lys Tyr Pro Ile 
305                 310                 315                 320 


Thr Val Phe Cys Ser Ala Pro Thr Val Tyr Arg Met Leu Val Gln Asn 
                325                 330                 335     


Asp Ile Thr Ser Tyr Lys Phe Lys Ser Leu Lys His Cys Val Ser Ala 
            340                 345                 350         


Gly Glu Pro Ile Thr Pro Asp Val Thr Glu Lys Trp Arg Asn Lys Thr 
        355                 360                 365             


Gly Leu Asp Ile Tyr Glu Gly Tyr Gly Gln Thr Glu Thr Val Leu Ile 
    370                 375                 380                 


Cys Gly Asn Phe Lys Gly Met Lys Ile Lys Pro Gly Ser Met Gly Lys 
385                 390                 395                 400 


Pro Ser Pro Ala Phe Asp Val Lys Ile Val Asp Val Asn Gly Asn Val 
                405                 410                 415     


Leu Pro Pro Gly Gln Glu Gly Asp Ile Gly Ile Gln Val Leu Pro Asn 
            420                 425                 430         


Arg Pro Phe Gly Leu Phe Thr His Tyr Val Asp Asn Pro Ser Lys Thr 
        435                 440                 445             


Ala Ser Thr Leu Arg Gly Asn Phe Tyr Ile Thr Gly Asp Arg Gly Tyr 
    450                 455                 460                 


Met Asp Lys Asp Gly Tyr Phe Trp Phe Val Ala Arg Ala Asp Asp Val 
465                 470                 475                 480 


Ile Leu Ser Ser Gly Tyr Arg Ile Gly Pro Phe Glu Val Glu Asn Ala 
                485                 490                 495     


Leu Asn Glu His Pro Ser Val Ala Glu Ser Ala Val Val Ser Ser Pro 
            500                 505                 510         


Asp Pro Ile Arg Gly Glu Val Val Lys Ala Phe Val Val Leu Asn Pro 
        515                 520                 525             


Asp Tyr Lys Ser His Asp Gln Glu Gln Leu Ile Lys Glu Ile Gln Glu 
    530                 535                 540                 


His Val Lys Lys Thr Thr Ala Pro Tyr Lys Tyr Pro Arg Lys Val Glu 
545                 550                 555                 560 


Phe Ile Gln Glu Leu Pro Lys Thr Ile Ser Gly Lys Thr Lys Arg Asn 
                565                 570                 575     


Glu Leu Arg Lys Lys Glu Trp Lys Thr Ile 
            580                 585     


<210>  307
<211>  2116
<212>  DNA
<213>  Homo sapiens

<400>  307
atcagaacca aattgctgag ccagtcacct gtgttccagg agccgaatca gaaatgtcat     60

cctcaggcac gccagactta cctgtcctac tcaccgattt gaagattcaa tatactaaga    120

tcttcataaa caatgaatgg catgattcag tgagtggcaa gaaatttcct gtctttaatc    180

ctgcaactga ggaggagctc tgccaggtag aagaaggaga taaggaggat gttgacaagg    240

cagtgaaggc cgcaagacag gcttttcaga ttggatcccc gtggcgtact atggatgctt    300

ccgagagggg gcgactatta tacaagttgg ctgatttaat cgaaagagat cgtctgctgc    360

tggcgacaat ggagtcaatg aatggtggaa aactctattc caatgcatat ctgaatgatt    420

tagcaggctg catcaaaaca ttgcgctact gtgcaggttg ggctgacaag atccagggcc    480

gtacaatacc aattgatgga aattttttta catatacaag acatgaacct attggtgtat    540

gtggccaaat cattccttgg aatttcccgt tggttatgct catttggaag atagggcctg    600

cactgagctg tggaaacaca gtggttgtca aaccagcaga gcaaactcct ctcactgctc    660

tccacgtggc atctttaata aaagaggcag ggtttcctcc tggagtagtg aatattgttc    720

ctggttatgg gcctacagca ggggcagcca tttcttctca catggatata gacaaagtag    780

ccttcacagg atcaacagag gttggcaagt tgatcaaaga agctgccggg aaaagcaatc    840

tgaagagggt gaccctggag cttggaggaa agagcccttg cattgtgtta gctgatgccg    900

acttggacaa tgctgttgaa tttgcacacc atggggtatt ctaccaccag ggccagtgtt    960

gtatagccgc atccaggatt tttgtggaag aatcaattta tgatgagttt gttcgaagga   1020

gtgttgagcg ggctaagaag tatatccttg gaaatcctct gaccccagga gtcactcaag   1080

gccctcagat tgacaaggaa caatatgata aaatacttga cctcattgag agtgggaaga   1140

aagaaggggc caaactggaa tgtggaggag gcccgtgggg gaataaaggc tactttgtcc   1200

agcccacagt gttctctaat gttacagatg agatgcgcat tgccaaagag gagatttttg   1260

gaccagtgca gcaaatcatg aagtttaaat ctttagatga cgtgatcaaa agagcaaaca   1320

atactttcta tggcttatca gcaggagtgt ttaccaaaga cattgataaa gccataacaa   1380

tctcctctgc tctgcaggca ggaacagtgt gggtgaattg ctatggcgtg gtaagtgccc   1440

agtgcccctt tggtggattc aagatgtctg gaaatggaag agaactggga gagtacggtt   1500

tccatgaata tacagaggtc aaaacagtca cagtgaaaat ctctcagaag aactcataaa   1560

gaaaatacaa gagtggagag aagctcttca atagctaagc atctccttac agtcactaat   1620

atagtagatt ttaaagacaa aatttttctt ttcttgattt ttttaaacat aagctaaatc   1680

atattagtat taatactacc catagaaaac ttgacatgta gcttcttctg aaagaattat   1740

ttgccttctg aaatgtgacc cccaagtcct atcctaaata aaaaaagaca aattcggatg   1800

tatgatctct ctagctttgt catagttatg tgattttcct ttgtagctac ttttgcagga   1860

taataatttt atagaaaagg aacagttgca tttagcttct ttcccttagt gactcttgaa   1920

gtacttaaca tacacgttaa ctgcagagta aattgctctg ttcccagtag ttataaagtc   1980

cttggactgt tttgaaaagt ttcctaggat gtcatgtctg cttgtcaaaa gaaataatcc   2040

ctgtaatatt tagctgtaaa ctgaatataa agcttaataa aaacaacctt gcatgaaaaa   2100

aaaaaaaaaa aaaaaa                                                   2116


<210>  308
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Ser Ser Ser Gly Thr Pro Asp Leu Pro Val Leu Leu Thr Asp Leu 
1               5                   10                  15      


Lys Ile Gln Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser 
            20                  25                  30          


Val Ser Gly Lys Lys Phe Pro Val Phe Asn Pro Ala Thr Glu Glu Glu 
        35                  40                  45              


Leu Cys Gln Val Glu Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
    50                  55                  60                  


Lys Ala Ala Arg Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met 
65                  70                  75                  80  


Asp Ala Ser Glu Arg Gly Arg Leu Leu Tyr Lys Leu Ala Asp Leu Ile 
                85                  90                  95      


Glu Arg Asp Arg Leu Leu Leu Ala Thr Met Glu Ser Met Asn Gly Gly 
            100                 105                 110         


Lys Leu Tyr Ser Asn Ala Tyr Leu Asn Asp Leu Ala Gly Cys Ile Lys 
        115                 120                 125             


Thr Leu Arg Tyr Cys Ala Gly Trp Ala Asp Lys Ile Gln Gly Arg Thr 
    130                 135                 140                 


Ile Pro Ile Asp Gly Asn Phe Phe Thr Tyr Thr Arg His Glu Pro Ile 
145                 150                 155                 160 


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Leu 
                165                 170                 175     


Ile Trp Lys Ile Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val 
            180                 185                 190         


Lys Pro Ala Glu Gln Thr Pro Leu Thr Ala Leu His Val Ala Ser Leu 
        195                 200                 205             


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
    210                 215                 220                 


Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ser Ser His Met Asp Ile Asp 
225                 230                 235                 240 


Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu 
                245                 250                 255     


Ala Ala Gly Lys Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         


Lys Ser Pro Cys Ile Val Leu Ala Asp Ala Asp Leu Asp Asn Ala Val 
        275                 280                 285             


Glu Phe Ala His His Gly Val Phe Tyr His Gln Gly Gln Cys Cys Ile 
    290                 295                 300                 


Ala Ala Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val 
305                 310                 315                 320 


Arg Arg Ser Val Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu 
                325                 330                 335     


Thr Pro Gly Val Thr Gln Gly Pro Gln Ile Asp Lys Glu Gln Tyr Asp 
            340                 345                 350         


Lys Ile Leu Asp Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu 
        355                 360                 365             


Glu Cys Gly Gly Gly Pro Trp Gly Asn Lys Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 


Thr Val Phe Ser Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu 
385                 390                 395                 400 


Ile Phe Gly Pro Val Gln Gln Ile Met Lys Phe Lys Ser Leu Asp Asp 
                405                 410                 415     


Val Ile Lys Arg Ala Asn Asn Thr Phe Tyr Gly Leu Ser Ala Gly Val 
            420                 425                 430         


Phe Thr Lys Asp Ile Asp Lys Ala Ile Thr Ile Ser Ser Ala Leu Gln 
        435                 440                 445             


Ala Gly Thr Val Trp Val Asn Cys Tyr Gly Val Val Ser Ala Gln Cys 
    450                 455                 460                 


Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu 
465                 470                 475                 480 


Tyr Gly Phe His Glu Tyr Thr Glu Val Lys Thr Val Thr Val Lys Ile 
                485                 490                 495     


Ser Gln Lys Asn Ser 
            500     


<210>  309
<211>  6540
<212>  DNA
<213>  Homo sapiens

<400>  309
tgctgatcgc tcgtgccggt gcggccgtta accgcccttg ccggagccct aggctcaaaa     60

gcagcccctt acccttcctg ggcttccccc aacccctttc ccggtctgcc ctggggcatg    120

agcagcgatg gccggctgca tccctgagga gaaaacttac cggcgcttcc tggagctatt    180

cctgggcgag tttcgcggac cgtgcggcgg cggcgagccg gagccggaac ccgaacccga    240

acccgaaccc gaacccgagt ccgagcccga gcccgaacct gaactggtag aagctgaggc    300

ggccgaggct tcggtagagg aacccgggga ggaggcggcc acggtagccg cgacggagga    360

gggggaccag gagcaagacc cggagcccga ggaggaggcg gcggttgagg gtgaggagga    420

ggaggagggc gcggcgacgg cggcggcagc cccggggcac tcggccgtgc cgccgccgcc    480

gccccagctg ccgcctttgc ccccgctccc gcgaccgctg tcagagcgca tcacccgcga    540

ggaggtggag ggcgaaagcc tggacctgtg cctgcagcag ctctacaaat ataattgccc    600

ttcctttttg gctgctgctt tagccagagc cacatcagat gaagtccttc agagtgatct    660

ttctgcacat tatatcccaa aggaaacgga tggcacagaa gggactgtgg agattgagac    720

agtgaaattg gcccgttctg tcttcagcaa actacacgag atttgctgca gctgggtgaa    780

agacttcccc ctccgcagga gaccccagct ttattatgag acatcaatcc atgccatcaa    840

aaacatgcgc aggaaaatgg aggacaaaca tgtctgcatt cctgacttta atatgctctt    900

caacctagag gaccaggaag aacaagctta ctttgcagtg tttgatggcc atgggggagt    960

agatgctgct atttatgcct ccattcacct ccacgttaac ttagtccgcc aggagatgtt   1020

cccccatgat cctgctgagg ccctgtgcag ggccttccgg gtcactgatg agcggtttgt   1080

gcagaaagca gccagggaga gcttaagatg tgggaccaca ggagtggtga ctttcatcag   1140

aggcaacatg ctacatgtgg cctgggtggg tgattcccag gttatgcttg tgagaaaggg   1200

ccaagctgtt gaactaatga agccacacaa accagacaga gaggatgaaa agcagagaat   1260

tgaggccctt ggaggttgcg tagtctggtt tggtgcctgg agggtgaatg gaagtctgtc   1320

ggtttccaga gctattggag atgctgaaca taagccatat atctgtgggg atgcagattc   1380

tgcctccact gttctggatg ggaccgaaga ctacctcatt ctggcctgtg atggcttcta   1440

tgacaccgtg aaccctgatg aggcagtgaa agttgtgtcc gaccacctga aagagaataa   1500

tggagacagc agcatggttg cccacaaatt agtggcatca gctcgtgatg ctgggtcaag   1560

tgataacatc acggttattg tggtattcct gagggacatg aacaaagctg taaatgttag   1620

tgaggaatca gattggacag agaactcttt tcaaggaggg caagaagatg gtggggatga   1680

taaggagaat catggagagt gcaaacgccc ttggcctcag caccagtgct cagcaccagc   1740

cgacctaggc tatgatgggc gtgtggattc attcactgat agaactagcc tgagcccagg   1800

gtcccaaatc aacgtgctgg aagacccagg ctacctagat ctcacacaaa tagaagcaag   1860

caaacctcac agtgcccagt ttttgctacc agttgagatg tttggtcctg gtgcaccaaa   1920

gaaagcaaat cttattaatg agttaatgat ggagaaaaaa tcagttcagt catcattgcc   1980

tgaatggagt ggtgctggag agtttcccac tgctttcaat ttgggttcaa caggggagca   2040

gatatacaga atgcagagct tgtctcctgt ctgttcaggg ttggaaaatg aacagttcaa   2100

atccccggga aacagagttt ctagattgtc tcatttacgc caccactact caaagaagtg   2160

gcacagattc aggtttaatc caaagtttta ttcatttctc tctgctcaag agccttccca   2220

caaaataggc actagcctgt cctcacttac tggaagtggg aagagaaata ggataagaag   2280

ttctctgcca tggaggcaaa atagttggaa agggtacagt gaaaacatga ggaagctcag   2340

aaagactcat gatattccat gcccagatct tccttggagc tataaaatag aataattttt   2400

ctttcaagta ggttagctag ctctccccca ataaaaatac cactatcaga gtagaaacaa   2460

ggtagacatt tctaaaacat atgtgcttca ttatgaatcc atggatggct caattcttaa   2520

atgtaaatag atctctagga aactcaaagt acagtgtttt caatctaaaa agaagtattg   2580

gcagtttcac ttgcaaaatt acacagctgg tccctgtgat gtgtctcgac accaatacac   2640

aacccccttc ccaccatcct tcatgtcact agatacacaa cccccttccc accatccctt   2700

cagtcactag tggaagcttt caagttagtt atttcagtca ggatatacag tgttgaaatc   2760

tcaatgcagt tgaaatctgg tctgatgtgc ctaatttatc tgtggaaaat ttaatgctga   2820

attacatttg gttgggaaat gtccctcaaa atcctgggca ctatgaagga accccctgcc   2880

ccctcacctt tttgggtagg taaaagacta aaagccatat ggattttaac tgataacaat   2940

gaaagtggta aatcagtgta aaagtgtcat attctcagac ttgtgaggcg gtttatagtc   3000

agaaagattt acggattttt ttcctgtaac ataaaagatt gtgaactttt tttaattaaa   3060

aaatatttcc tagggctgta gttatttggg agtttcataa cctgttatgg tgcttttggt   3120

ggaaattttt attatttagc attttaggag accgctgtca actggtttta atctatgatg   3180

ctaatgtgtt ttccactgta ccctcatctc aggaataaaa ctgctttaac ggagatgatg   3240

tcaggtacaa atacactata gagtcaaaat accatttaca aagaaaatca aaagcatttc   3300

tatattttgt ctttttttag ttcagacagc aaaggcatgt actactataa aatacaaagt   3360

gattttagag aatgaaaaat gctactttta tcttctctaa aattatttcc cccaaggtag   3420

tgaagtaatt ggaatgaagg aggctgaaag tattgtctaa agtgagccca gaggccactg   3480

agaatgcaga ttactgacag ccaggtctgt ttagttgtaa ttggaagaca catgagtgtc   3540

ctgcttacat gtagcttcag actgcagaga caggacgtgt gcttttcatt tcaatattta   3600

gttatatttg atattttgaa actgtctgct ttttgctatt tctgcagttt caagttagtt   3660

agaagcatgt tgtcaactaa agacaacaaa ctatcagatt cattcattca gtgaagcagc   3720

ctctgattct ctaagagtca cgaatgtctt agtgttaccc tcccctagtc aacagcagac   3780

cagcctggcc aatgcctatg ggtggcccct ctggagtgct cactaacaag ggtgagtgct   3840

ctcgctaaga agtgtccccc gcctaatcat gtgtttatag gatagtacac gttccccagg   3900

cccataacag aggactaaaa tctctgaatt ttaaagacac agatgactgg catattttgg   3960

ataccagtat agctatatca aatagacaaa aacagcttca ctttagcaat gatcagattg   4020

ttaatctaca gattttattt tttaaaattt ggatgtaagt agagactttc agtatttgtt   4080

ttctcttgat tttgaagtca tttcttcttc tcacgtctgt gacaaatggt tgaaaaggag   4140

tcaacatggc cccaactata gtgccggaac cttttcatca ttctgaggct ttgccccaca   4200

catggtcctc actcatatct gtcaccttct gaagcctaga tcttgttaac ccatcaggtg   4260

cagtgtcagt ttcaaatcaa attatctaag aaaacaagaa aacaaaggca gcagactatt   4320

ggtacacatt atagtccaaa gtgcttagcg aagtaaaaaa aaaagctttt taaaatttct   4380

attgttgtct attggtaatg tttttgatca gaataaagag ggtaaaggga aaaagttact   4440

acacatgcta ggctttctca gtggggaaaa aaatggctgg atagaactgg gacaaacaca   4500

gacccatctt taggggtctg gattttgtag gtccgactac acagcagtgt taactcattt   4560

ctcatgccat tagctctcta caaaataaag caaagtagtt ctagtgtggt cgttataaac   4620

caatattgtg aaaaatagca actattcatt tgttcacaac atgcgtattt atagagtagt   4680

taggtaccat ttgtaaggta aatcctttaa aattctataa tacatactaa aatagtggtt   4740

attggtctga tatatgctgc tcttggttct ataaactaga taaaagcagt gctttgtgaa   4800

atgcagtgtt ctctcttaac gccactggtg ataggaagta gttcccttca gttcaaatcc   4860

tgtgccctta tttgctgctt gctgacgtaa gcaataagta accctctaac taatggtatc   4920

tacatatttc tgtaacttgt atttaatgat ggtgtacctg gtgattgtaa aaatattaga   4980

cagatataaa agtatctata taatatctat aaactgttaa tgctgaggta tagtctgtga   5040

attatgtgtt ttgtattttt attcattgtg taatttagtg gtggtgaaag ttctacactc   5100

aatccttaaa gagtggcagt atcccttttt caatttaaca tggtctgcat caatctgttt   5160

gcctgctaaa caagttagaa taggaaatag taaaataaat ccaaacaaga gtgtaatatt   5220

ggttagggaa acaaacttca ggtcaccaac tgaagtcatt acaaactcct tgtacattca   5280

ctgtgagttt caaagggagt cagtccctaa tttacaggtt tcctttgttc actttctaga   5340

tgtgtacttt tgagggacat gaggttaggc aacattacag caacacacac tggggctatt   5400

aatcccattt aggtctgtac taaagaggat gggtagaaac acatatgtat ataccttttc   5460

tttacctaga agtgccatcc attgtccttg aattattatg attaaagtta ctgttgcatt   5520

taggaggctc cttgaaagta acaccttttc caaggacaat ggcaacaatg tcaatgtcaa   5580

cactgagtct aattttgacc acatttatag tggtatagtg tcaatactgc attttcatga   5640

caaccacact ccactgttga aacactgtgc cagtgagaag tgcaacatcc agtgggcaga   5700

tgaaaatgat gcatggccaa gttcagtgtt tacagataaa actgctgtgg ttcaagtgct   5760

tccttcccca tcaaatcctt gataaggctt tgtgggaaaa tgatctaaat tattgtttta   5820

atttttaaac ctaatttatt cactcagtga acattcttac ctaagcaagg ctataaaagg   5880

gaatactaca gttttgtcca cactttaatt tgagaccatt tttctttgaa tcgtaagtta   5940

gcaaaagaaa tttttttcac ctttgaaaat cacgtgatgt taaaggacaa atgcccactc   6000

ttctattctg atctgcaaat agcttaaatg tctcttgcaa aacaaagtaa gataccacca   6060

gtattacaac acaatgattt tccagacaaa tggtatggtg ttgaaaaata actgttactt   6120

cttaaagcag cattttatct tctattttga agactattta ttgtaataat tagaaaacat   6180

gaaataggga actccagact gacacagcag ttgtttttga aaaggaaata aactttgatg   6240

aattagataa tccagataca tcattgtaaa ctcttactct aggtgctctt tggtgagaga   6300

caggctttgt tctcttgttc ataacatttc tctgcaaaga attctctatg gagtgaagcg   6360

aatgaagtga ataatttctt accaaataaa tttatcaatt tacaaatctg ctctacatct   6420

cacttttgag ttcagttgta gtcatgagtg atccttcata ttttattaaa agtgttcatt   6480

caggtaaggt gtatgttgaa attttgccaa ttatcttaat aaaacctggc aatttaaaaa   6540


<210>  310
<211>  755
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Ala Gly Cys Ile Pro Glu Glu Lys Thr Tyr Arg Arg Phe Leu Glu 
1               5                   10                  15      


Leu Phe Leu Gly Glu Phe Arg Gly Pro Cys Gly Gly Gly Glu Pro Glu 
            20                  25                  30          


Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Ser Glu Pro Glu 
        35                  40                  45              


Pro Glu Pro Glu Leu Val Glu Ala Glu Ala Ala Glu Ala Ser Val Glu 
    50                  55                  60                  


Glu Pro Gly Glu Glu Ala Ala Thr Val Ala Ala Thr Glu Glu Gly Asp 
65                  70                  75                  80  


Gln Glu Gln Asp Pro Glu Pro Glu Glu Glu Ala Ala Val Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Gly Ala Ala Thr Ala Ala Ala Ala Pro Gly His Ser 
            100                 105                 110         


Ala Val Pro Pro Pro Pro Pro Gln Leu Pro Pro Leu Pro Pro Leu Pro 
        115                 120                 125             


Arg Pro Leu Ser Glu Arg Ile Thr Arg Glu Glu Val Glu Gly Glu Ser 
    130                 135                 140                 


Leu Asp Leu Cys Leu Gln Gln Leu Tyr Lys Tyr Asn Cys Pro Ser Phe 
145                 150                 155                 160 


Leu Ala Ala Ala Leu Ala Arg Ala Thr Ser Asp Glu Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Ser Ala His Tyr Ile Pro Lys Glu Thr Asp Gly Thr Glu Gly 
            180                 185                 190         


Thr Val Glu Ile Glu Thr Val Lys Leu Ala Arg Ser Val Phe Ser Lys 
        195                 200                 205             


Leu His Glu Ile Cys Cys Ser Trp Val Lys Asp Phe Pro Leu Arg Arg 
    210                 215                 220                 


Arg Pro Gln Leu Tyr Tyr Glu Thr Ser Ile His Ala Ile Lys Asn Met 
225                 230                 235                 240 


Arg Arg Lys Met Glu Asp Lys His Val Cys Ile Pro Asp Phe Asn Met 
                245                 250                 255     


Leu Phe Asn Leu Glu Asp Gln Glu Glu Gln Ala Tyr Phe Ala Val Phe 
            260                 265                 270         


Asp Gly His Gly Gly Val Asp Ala Ala Ile Tyr Ala Ser Ile His Leu 
        275                 280                 285             


His Val Asn Leu Val Arg Gln Glu Met Phe Pro His Asp Pro Ala Glu 
    290                 295                 300                 


Ala Leu Cys Arg Ala Phe Arg Val Thr Asp Glu Arg Phe Val Gln Lys 
305                 310                 315                 320 


Ala Ala Arg Glu Ser Leu Arg Cys Gly Thr Thr Gly Val Val Thr Phe 
                325                 330                 335     


Ile Arg Gly Asn Met Leu His Val Ala Trp Val Gly Asp Ser Gln Val 
            340                 345                 350         


Met Leu Val Arg Lys Gly Gln Ala Val Glu Leu Met Lys Pro His Lys 
        355                 360                 365             


Pro Asp Arg Glu Asp Glu Lys Gln Arg Ile Glu Ala Leu Gly Gly Cys 
    370                 375                 380                 


Val Val Trp Phe Gly Ala Trp Arg Val Asn Gly Ser Leu Ser Val Ser 
385                 390                 395                 400 


Arg Ala Ile Gly Asp Ala Glu His Lys Pro Tyr Ile Cys Gly Asp Ala 
                405                 410                 415     


Asp Ser Ala Ser Thr Val Leu Asp Gly Thr Glu Asp Tyr Leu Ile Leu 
            420                 425                 430         


Ala Cys Asp Gly Phe Tyr Asp Thr Val Asn Pro Asp Glu Ala Val Lys 
        435                 440                 445             


Val Val Ser Asp His Leu Lys Glu Asn Asn Gly Asp Ser Ser Met Val 
    450                 455                 460                 


Ala His Lys Leu Val Ala Ser Ala Arg Asp Ala Gly Ser Ser Asp Asn 
465                 470                 475                 480 


Ile Thr Val Ile Val Val Phe Leu Arg Asp Met Asn Lys Ala Val Asn 
                485                 490                 495     


Val Ser Glu Glu Ser Asp Trp Thr Glu Asn Ser Phe Gln Gly Gly Gln 
            500                 505                 510         


Glu Asp Gly Gly Asp Asp Lys Glu Asn His Gly Glu Cys Lys Arg Pro 
        515                 520                 525             


Trp Pro Gln His Gln Cys Ser Ala Pro Ala Asp Leu Gly Tyr Asp Gly 
    530                 535                 540                 


Arg Val Asp Ser Phe Thr Asp Arg Thr Ser Leu Ser Pro Gly Ser Gln 
545                 550                 555                 560 


Ile Asn Val Leu Glu Asp Pro Gly Tyr Leu Asp Leu Thr Gln Ile Glu 
                565                 570                 575     


Ala Ser Lys Pro His Ser Ala Gln Phe Leu Leu Pro Val Glu Met Phe 
            580                 585                 590         


Gly Pro Gly Ala Pro Lys Lys Ala Asn Leu Ile Asn Glu Leu Met Met 
        595                 600                 605             


Glu Lys Lys Ser Val Gln Ser Ser Leu Pro Glu Trp Ser Gly Ala Gly 
    610                 615                 620                 


Glu Phe Pro Thr Ala Phe Asn Leu Gly Ser Thr Gly Glu Gln Ile Tyr 
625                 630                 635                 640 


Arg Met Gln Ser Leu Ser Pro Val Cys Ser Gly Leu Glu Asn Glu Gln 
                645                 650                 655     


Phe Lys Ser Pro Gly Asn Arg Val Ser Arg Leu Ser His Leu Arg His 
            660                 665                 670         


His Tyr Ser Lys Lys Trp His Arg Phe Arg Phe Asn Pro Lys Phe Tyr 
        675                 680                 685             


Ser Phe Leu Ser Ala Gln Glu Pro Ser His Lys Ile Gly Thr Ser Leu 
    690                 695                 700                 


Ser Ser Leu Thr Gly Ser Gly Lys Arg Asn Arg Ile Arg Ser Ser Leu 
705                 710                 715                 720 


Pro Trp Arg Gln Asn Ser Trp Lys Gly Tyr Ser Glu Asn Met Arg Lys 
                725                 730                 735     


Leu Arg Lys Thr His Asp Ile Pro Cys Pro Asp Leu Pro Trp Ser Tyr 
            740                 745                 750         


Lys Ile Glu 
        755 


<210>  311
<211>  1453
<212>  DNA
<213>  Homo sapiens

<400>  311
ggccacgaag gccggccccc accccgggac ccccgccgtc cccgggccgg ccggccggtg     60

ggcacgatga gccaggtgct ggggaagccg cagccgcagg acgaggacga cgcggaggag    120

gaggaggagg aggatgagct ggtggggcta gcggactacg gagacgggcc cgactcctcc    180

gacgccgatc cggacagcgg cacagaggag ggagttctgg acttcagtga ccccttcagc    240

actgaagtga agccgagaat cctgctcatg ggcctgagga gaagcggcaa gtcgtctatt    300

cagaaagttg tctttcacaa aatgtctccc aacgaaactc tgttcttgga gagcactaat    360

aagatatgcc gggaagatgt ttccaacagc tcctttgtca attttcagat ttgggacttc    420

ccaggacaga ttgacttttt tgaccctaca tttgactatg agatgatctt ccggggaaca    480

ggagcactga tatttgtcat tgactcacag gatgattaca tggaagccct ggccaggctc    540

cacctcacgg tgaccagggc ctacaaagtg aatactgaca tcaacttcga ggtgtttatt    600

cataaagtgg atggtctgtc agatgaccac aaaattgaaa cccaaagaga tattcaccag    660

agggcaaacg atgaccttgc agatgctgga ttagaaaaaa ttcacctcag cttttatctg    720

acaagcatat atgatcattc aatatttgaa gcttttagca aagttgttca gaaactgatt    780

ccacaactcc caactctgga gaatttgctg aacatcttta tctcaaattc tggaattgaa    840

aaggcatttc tatttgatgt ggtcagtaaa atttatattg caactgatag tactccggtg    900

gatatgcaaa cctatgagct ctgctgtgat atgatagatg tggttattga catctcttgt    960

atttatggtc tcaaagaaga tggagcagga accccctatg acaaggaatc cacagccatc   1020

ataaagctta ataatacaac cgtgctttat ttaaaagagg tgacaaagtt cctggctctc   1080

gtttgctttg tcagagagga aagctttgaa agaaaagggc taattgacta taattttcat   1140

tgcttccgga aggccattca tgaagttttt gaggtgagaa tgaaagtagt aaaatctcga   1200

aaggttcaga atcggctgca gaagaaaaag agagccaccc ctaatgggac ccctagagtg   1260

ctgctgtagg tgaggtttca ggaatgtctt ttgaaatcag accttatcca tgaggctgct   1320

gcgccatgtt gcactaaagg aagaggaaga aggagattgg gacacatacc attgatttgt   1380

tgttaaaaaa aaaaaaattc ctgcaaccct cttgatcttc tcttttataa ttaaagtcag   1440

cacttgaagc ggg                                                      1453


<210>  312
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Ser Gln Val Leu Gly Lys Pro Gln Pro Gln Asp Glu Asp Asp Ala 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Asp Glu Leu Val Gly Leu Ala Asp Tyr Gly 
            20                  25                  30          


Asp Gly Pro Asp Ser Ser Asp Ala Asp Pro Asp Ser Gly Thr Glu Glu 
        35                  40                  45              


Gly Val Leu Asp Phe Ser Asp Pro Phe Ser Thr Glu Val Lys Pro Arg 
    50                  55                  60                  


Ile Leu Leu Met Gly Leu Arg Arg Ser Gly Lys Ser Ser Ile Gln Lys 
65                  70                  75                  80  


Val Val Phe His Lys Met Ser Pro Asn Glu Thr Leu Phe Leu Glu Ser 
                85                  90                  95      


Thr Asn Lys Ile Cys Arg Glu Asp Val Ser Asn Ser Ser Phe Val Asn 
            100                 105                 110         


Phe Gln Ile Trp Asp Phe Pro Gly Gln Ile Asp Phe Phe Asp Pro Thr 
        115                 120                 125             


Phe Asp Tyr Glu Met Ile Phe Arg Gly Thr Gly Ala Leu Ile Phe Val 
    130                 135                 140                 


Ile Asp Ser Gln Asp Asp Tyr Met Glu Ala Leu Ala Arg Leu His Leu 
145                 150                 155                 160 


Thr Val Thr Arg Ala Tyr Lys Val Asn Thr Asp Ile Asn Phe Glu Val 
                165                 170                 175     


Phe Ile His Lys Val Asp Gly Leu Ser Asp Asp His Lys Ile Glu Thr 
            180                 185                 190         


Gln Arg Asp Ile His Gln Arg Ala Asn Asp Asp Leu Ala Asp Ala Gly 
        195                 200                 205             


Leu Glu Lys Ile His Leu Ser Phe Tyr Leu Thr Ser Ile Tyr Asp His 
    210                 215                 220                 


Ser Ile Phe Glu Ala Phe Ser Lys Val Val Gln Lys Leu Ile Pro Gln 
225                 230                 235                 240 


Leu Pro Thr Leu Glu Asn Leu Leu Asn Ile Phe Ile Ser Asn Ser Gly 
                245                 250                 255     


Ile Glu Lys Ala Phe Leu Phe Asp Val Val Ser Lys Ile Tyr Ile Ala 
            260                 265                 270         


Thr Asp Ser Thr Pro Val Asp Met Gln Thr Tyr Glu Leu Cys Cys Asp 
        275                 280                 285             


Met Ile Asp Val Val Ile Asp Ile Ser Cys Ile Tyr Gly Leu Lys Glu 
    290                 295                 300                 


Asp Gly Ala Gly Thr Pro Tyr Asp Lys Glu Ser Thr Ala Ile Ile Lys 
305                 310                 315                 320 


Leu Asn Asn Thr Thr Val Leu Tyr Leu Lys Glu Val Thr Lys Phe Leu 
                325                 330                 335     


Ala Leu Val Cys Phe Val Arg Glu Glu Ser Phe Glu Arg Lys Gly Leu 
            340                 345                 350         


Ile Asp Tyr Asn Phe His Cys Phe Arg Lys Ala Ile His Glu Val Phe 
        355                 360                 365             


Glu Val Arg Met Lys Val Val Lys Ser Arg Lys Val Gln Asn Arg Leu 
    370                 375                 380                 


Gln Lys Lys Lys Arg Ala Thr Pro Asn Gly Thr Pro Arg Val Leu Leu 
385                 390                 395                 400 


<210>  313
<211>  2769
<212>  DNA
<213>  Homo sapiens

<400>  313
aagacgctca gaggattctg acaatatctt taccggagaa gaggcaaagt acgctcaaag     60

ccgaagccac agctcctcct gccgcatttc tttcctgctt gcgaattcca agctgttaaa    120

taagatgtgc aaagggcttg caggtctgcc ggcttcttgc ttgaggagtg caaaagatat    180

gaaacatcgg ctaggtttcc tgctgcaaaa atctgattcc tgtgaacaca attcttccca    240

caacaagaag gacaaagtgg ttatttgcca gagagtgagc caagaggaag tcaagaaatg    300

ggctgaatca ctggaaaacc tgattagtca tgaatgtggg ctggcagctt tcaaagcttt    360

cttgaagtct gaatatagtg aggagaatat tgacttctgg atcagctgtg aagagtacaa    420

gaaaatcaaa tcaccatcta aactaagtcc caaggccaaa aagatctata atgaattcat    480

ctcagtccag gcaaccaaag aggtgaacct ggattcttgc accagggaag agacaagccg    540

gaacatgcta gagcctacaa taacctgctt tgatgaggcc cagaagaaga ttttcaacct    600

gatggagaag gattcctacc gccgcttcct caagtctcga ttctatcttg atttggtcaa    660

cccgtccagc tgtggggcag aaaagcagaa aggagccaag agttcagcag actgtgcttc    720

cctggtccct cagtgtgcct aattctcacc tgaaggcaga gggatgaaat gccaagactc    780

tatgctctgg aaaacctgag gccaaatatt gatctgtatt aagctccagt gctttatcca    840

cattgtagcc taatattcat gctgcctgcc atgtgtgagt cacttctacg cataaactag    900

atatagcttt tggtgtttga gtgttcatca gggtgggacc ccattccagt ccaattttcc    960

taagtttctt tgagggttcc atgggagcaa atatctaaat aatggcctgg taggtctgga   1020

ttttcaaaga ttgttggcag tttcctcctc ccaacagttt tacctcggga tggttggtta   1080

gtgcatgtca catgacatcc acatgcacat gtattctgtt ggccagcacg ttctccagac   1140

tctagatgtt tagatgaggt tgagctatga tatgtgcttg tgtgtatgtc tatgtgtata   1200

tattatatat acattagaca cacatataca ttatttctgt atatagatgt ctgtgtatac   1260

atatgtatgt gtgagtgtat gtacacacac acacacacac acacacactt ttgcaagagt   1320

gatgggaaag accctaggtg ctcataacta gagtatgtgt atgtacttac atgggtgttt   1380

tgatctctgt tctttcatac tacatttgaa cagggcaaaa tgaactaact gccatgtagg   1440

ctaagaaaga aatgctaacc tgtggaaagt tggttttgta aaattccatg gatcttgctg   1500

gagaagcatc caaggaactt catgcttgat ttgaccactg acagcctcca ccttgagcac   1560

tattctaagg agcaaatacc ttagctccct tgagctggtt ttctctgatg gcacttttga   1620

gctcctaagc tgccagcctt cccttctttt cctgggtgct cagggcatgc ttattagcag   1680

ctgggttggt atggagttgg cagacaggat gttcaactta atgaagaaat acagctaagg   1740

ccttgccagc aacacctgcc gtaagttact ggctgagtga gggcatagaa gttaaaggtt   1800

actgttttta tcctctatcc ttttttcctt tcctgatcaa ggtgctcttc tcattttttc   1860

ctgagaacct tagccatcag atgaggctcc ttagtttatt gtggttggtt gttttttctt   1920

tataatggct ctgggctata tgcccatatt tataaaccag cagcagggga aagattatat   1980

tttataagag ggaacaaatt ttcacaattt gaaaagccca cataagtttt ctcttttaag   2040

gtagaatctt gttaatttca ttccaaacat cggggctaac agagactgga ggcatttctt   2100

tttaggctct gagactaaat gagaggaaaa gaaaagaaaa aaaaatgatt gtctaaccaa   2160

ttgtgagaat tactgtttga aacttttcaa ggcacattga aatacttgaa aacttctcat   2220

ttatgttatt tatgatgtta ttttgtacgt gttattatta ttatattgtt ttataaatgg   2280

aggtacagga tatcacctga attattaatg aatgcccagg aagtaatttt cttctcattc   2340

ttctaaaact actgcctttc aaagtgcaca cacacgcgtc cacatacact gcattcgttg   2400

ctccagtata aattacatgc atgagcacct ttctggcttt taagccaata taatgggctg   2460

caaaatgaag acaccagagt gtatgcatac aaatctcact gtattaaaga tgcaggtttt   2520

ctaattgtac ccttcttgtc tctctggcaa tcttgccctt aatatccctg gagttcctca   2580

tcagtgtcat tttctgttat acacagttcc acaattttgt ctctagttga cttcaaatgt   2640

gtaactttat tggtcttgcc ctattataat tgtcatgact ttcagattgt atctgaactc   2700

acagactgct gtcttactaa taggtctgga aggtcacgct gaatgagaag taaattattt   2760

tatgtaaaa                                                           2769


<210>  314
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Cys Lys Gly Leu Ala Gly Leu Pro Ala Ser Cys Leu Arg Ser Ala 
1               5                   10                  15      


Lys Asp Met Lys His Arg Leu Gly Phe Leu Leu Gln Lys Ser Asp Ser 
            20                  25                  30          


Cys Glu His Asn Ser Ser His Asn Lys Lys Asp Lys Val Val Ile Cys 
        35                  40                  45              


Gln Arg Val Ser Gln Glu Glu Val Lys Lys Trp Ala Glu Ser Leu Glu 
    50                  55                  60                  


Asn Leu Ile Ser His Glu Cys Gly Leu Ala Ala Phe Lys Ala Phe Leu 
65                  70                  75                  80  


Lys Ser Glu Tyr Ser Glu Glu Asn Ile Asp Phe Trp Ile Ser Cys Glu 
                85                  90                  95      


Glu Tyr Lys Lys Ile Lys Ser Pro Ser Lys Leu Ser Pro Lys Ala Lys 
            100                 105                 110         


Lys Ile Tyr Asn Glu Phe Ile Ser Val Gln Ala Thr Lys Glu Val Asn 
        115                 120                 125             


Leu Asp Ser Cys Thr Arg Glu Glu Thr Ser Arg Asn Met Leu Glu Pro 
    130                 135                 140                 


Thr Ile Thr Cys Phe Asp Glu Ala Gln Lys Lys Ile Phe Asn Leu Met 
145                 150                 155                 160 


Glu Lys Asp Ser Tyr Arg Arg Phe Leu Lys Ser Arg Phe Tyr Leu Asp 
                165                 170                 175     


Leu Val Asn Pro Ser Ser Cys Gly Ala Glu Lys Gln Lys Gly Ala Lys 
            180                 185                 190         


Ser Ser Ala Asp Cys Ala Ser Leu Val Pro Gln Cys Ala 
        195                 200                 205 


<210>  315
<211>  3695
<212>  DNA
<213>  Homo sapiens

<400>  315
gccccgtccc ggcctcgcgc acctgctcag gccatgatga gcttcggcgg cgcggacgcg     60

ctgctgggcg ccccgttcgc gccgctgcat ggcggcggca gcctccacta cgcgctagcc    120

cgaaagggtg gcgcaggcgg gacgcgctcc gccgctggct cctccagcgg cttccactcg    180

tggacacgga cgtccgtgag ctccgtgtcc gcctcgccca gccgcttccg tggcgcaggc    240

gccgcctcaa gcaccgactc gctggacacg ctgagcaacg ggccggaggg ctgcatggtg    300

gcggtggcca cctcacgcag tgagaaggag cagctgcagg cgctgaacga ccgcttcgcc    360

gggtacatcg acaaggtgcg gcagctggag gcgcacaacc gcagcctgga gggcgaggct    420

gcggcgctgc ggcagcagca ggcgggccgc tccgctatgg gcgagctgta cgagcgcgag    480

gtccgcgaga tgcgcggcgc ggtgctgcgc ctgggcgcgg cgcgcggtca gctacgcctg    540

gagcaggagc acctgctcga ggacatcgcg cacgtgcgcc agcgcctaga cgacgaggcc    600

cggcagcgag aggaggccga ggcggcggcc cgcgcgctgg cgcgcttcgc gcaggaggcc    660

gaggcggcgc gcgtggacct gcagaagaag gcgcaggcgc tgcaggagga gtgcggctac    720

ctgcggcgcc accaccagga agaggtgggc gagctgctcg gccagatcca gggctccggc    780

gccgcgcagg cgcagatgca ggccgagacg cgcgacgccc tgaagtgcga cgtgacgtcg    840

gcgctgcgcg agattcgcgc gcagcttgaa ggccacgcgg tgcagagcac gctgcagtcc    900

gaggagtggt tccgagtgag gctggaccga ctgtcggagg cagccaaggt gaacacagac    960

gctatgcgct cagcgcagga ggagataact gagtaccggc gtcagctgca ggccaggacc   1020

acagagctgg aggcactgaa aagcaccaag gactcactgg agaggcagcg ctctgagctg   1080

gaggaccgtc atcaggccga cattgcctcc taccaggaag ccattcagca gctggacgct   1140

gagctgagga acaccaagtg ggagatggcc gcccagctgc gagaatacca ggacctgctc   1200

aatgtcaaga tggctctgga tatagagata gccgcttaca gaaaactcct ggaaggtgaa   1260

gagtgtcgga ttggctttgg cccaattcct ttctcgcttc cagaaggact ccccaaaatt   1320

ccctctgtgt ccactcacat aaaggtgaaa agcgaagaga agatcaaagt ggtggagaag   1380

tctgagaaag aaactgtgat tgtggaggaa cagacagagg agacccaagt gactgaagaa   1440

gtgactgaag aagaggagaa agaggccaaa gaggaggagg gcaaggagga agaagggggt   1500

gaagaagagg aggcagaagg gggagaagaa gaaacaaagt ctcccccagc agaagaggct   1560

gcatccccag agaaggaagc caagtcacca gtaaaggaag aggcaaagtc accggctgag   1620

gccaagtccc cagagaagga ggaagcaaaa tccccagccg aagtcaagtc ccctgagaag   1680

gccaagtctc cagcaaagga agaggcaaag tcaccgcctg aggccaagtc cccagagaag   1740

gaggaagcaa aatctccagc tgaggtcaag tcccccgaga aggccaagtc cccagcaaag   1800

gaagaggcaa agtcaccggc tgaggccaag tctccagaga aggccaagtc cccagtgaag   1860

gaagaagcaa agtcaccggc tgaggccaag tccccagtga aggaagaagc aaaatctcca   1920

gctgaggtca agtccccgga aaaggccaag tctccaacga aggaggaagc aaagtcccct   1980

gagaaggcca agtccccaga gaaggaagag gccaagtccc ctgagaaggc caagtcccca   2040

gtgaaggcag aagcaaagtc ccctgagaag gccaagtccc cagtgaaggc agaagcaaag   2100

tcccctgaga aggccaagtc cccagtgaag gaagaagcaa agtcccctga gaaggccaag   2160

tccccagtga aggaagaagc aaagtcccct gagaaggcca agtccccagt gaaggaagaa   2220

gcaaagaccc ccgagaaggc caagtcccca gtgaaggaag aagccaagtc cccagagaag   2280

gccaagtccc cagagaaggc caagactctt gatgtgaagt ctccagaagc caagactcca   2340

gcgaaggagg aagcaaggtc ccctgcagac aaattccctg aaaaggccaa aagccctgtc   2400

aaggaggagg tcaagtcccc agagaaggcg aaatctcccc tgaaggagga tgccaaggcc   2460

cctgagaagg agatcccaaa aaaggaagag gtgaagtccc cagtgaagga ggaggagaag   2520

ccccaggagg tgaaagtcaa agagccccca aagaaggcag aggaagagaa agcccctgcc   2580

acaccaaaaa cagaggagaa gaaggacagc aagaaagagg aggcacccaa gaaggaggct   2640

ccaaagccca aggtggagga gaagaaggaa cctgctgtcg aaaagcccaa agaatccaaa   2700

gttgaagcca agaaggaaga ggctgaagat aagaaaaaag tccccacccc agagaaggag   2760

gctcctgcca aggtggaggt gaaggaagac gctaaaccca aagaaaagac agaggtagcc   2820

aagaaggaac cagatgatgc caaggccaag gaacccagca aaccagcaga gaagaaggag   2880

gcagcaccgg agaaaaaaga caccaaggag gagaaggcca agaagcctga ggagaaaccc   2940

aagacagagg ccaaagccaa ggaagatgac aagaccctct caaaagagcc tagcaagcct   3000

aaggcagaaa aggctgaaaa atcctccagc acagaccaaa aagacagcaa gcctccagag   3060

aaggccacag aagacaaggc cgccaagggg aagtaaggca gggagaaagg aacatccgga   3120

acagccaaag aaactcagaa gagtcccgga gctcaaggat cagagtaaca caattttcac   3180

tttttctgtc tttatgtaag aagaaactgc ttagatgacg gggcctcctt cttcaaacag   3240

gaatttctgt tagcaatatg ttagcaagag agggcactcc caggcccctg cccccaggcc   3300

ctccccaggc gatggacaat tatgatagct tatgtagctg aatgtgatac atgccgaatg   3360

ccacacgtaa acacttgact ataaaaactg cccccctcct ttccaaataa gtgcatttat   3420

tgcctctatg tgcaactgac agatgaccgc aataatgaat gagcagttag aaatacatta   3480

tgcttgagat gtcttaacct attcccaaat gccttctgtt ttccaaagga gtggtcaagc   3540

ccttgcccag agctctctat tctggaagag cggtccaggt ggggccgggg actggccact   3600

gaattatgcc agggcgcact ttccactgga gttcactttc aattgcttct gtgcaataaa   3660

accaagtgct tataaaatga aaaaaaaaaa aaaaa                              3695


<210>  316
<211>  1020
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Met Ser Phe Gly Gly Ala Asp Ala Leu Leu Gly Ala Pro Phe Ala 
1               5                   10                  15      


Pro Leu His Gly Gly Gly Ser Leu His Tyr Ala Leu Ala Arg Lys Gly 
            20                  25                  30          


Gly Ala Gly Gly Thr Arg Ser Ala Ala Gly Ser Ser Ser Gly Phe His 
        35                  40                  45              


Ser Trp Thr Arg Thr Ser Val Ser Ser Val Ser Ala Ser Pro Ser Arg 
    50                  55                  60                  


Phe Arg Gly Ala Gly Ala Ala Ser Ser Thr Asp Ser Leu Asp Thr Leu 
65                  70                  75                  80  


Ser Asn Gly Pro Glu Gly Cys Met Val Ala Val Ala Thr Ser Arg Ser 
                85                  90                  95      


Glu Lys Glu Gln Leu Gln Ala Leu Asn Asp Arg Phe Ala Gly Tyr Ile 
            100                 105                 110         


Asp Lys Val Arg Gln Leu Glu Ala His Asn Arg Ser Leu Glu Gly Glu 
        115                 120                 125             


Ala Ala Ala Leu Arg Gln Gln Gln Ala Gly Arg Ser Ala Met Gly Glu 
    130                 135                 140                 


Leu Tyr Glu Arg Glu Val Arg Glu Met Arg Gly Ala Val Leu Arg Leu 
145                 150                 155                 160 


Gly Ala Ala Arg Gly Gln Leu Arg Leu Glu Gln Glu His Leu Leu Glu 
                165                 170                 175     


Asp Ile Ala His Val Arg Gln Arg Leu Asp Asp Glu Ala Arg Gln Arg 
            180                 185                 190         


Glu Glu Ala Glu Ala Ala Ala Arg Ala Leu Ala Arg Phe Ala Gln Glu 
        195                 200                 205             


Ala Glu Ala Ala Arg Val Asp Leu Gln Lys Lys Ala Gln Ala Leu Gln 
    210                 215                 220                 


Glu Glu Cys Gly Tyr Leu Arg Arg His His Gln Glu Glu Val Gly Glu 
225                 230                 235                 240 


Leu Leu Gly Gln Ile Gln Gly Ser Gly Ala Ala Gln Ala Gln Met Gln 
                245                 250                 255     


Ala Glu Thr Arg Asp Ala Leu Lys Cys Asp Val Thr Ser Ala Leu Arg 
            260                 265                 270         


Glu Ile Arg Ala Gln Leu Glu Gly His Ala Val Gln Ser Thr Leu Gln 
        275                 280                 285             


Ser Glu Glu Trp Phe Arg Val Arg Leu Asp Arg Leu Ser Glu Ala Ala 
    290                 295                 300                 


Lys Val Asn Thr Asp Ala Met Arg Ser Ala Gln Glu Glu Ile Thr Glu 
305                 310                 315                 320 


Tyr Arg Arg Gln Leu Gln Ala Arg Thr Thr Glu Leu Glu Ala Leu Lys 
                325                 330                 335     


Ser Thr Lys Asp Ser Leu Glu Arg Gln Arg Ser Glu Leu Glu Asp Arg 
            340                 345                 350         


His Gln Ala Asp Ile Ala Ser Tyr Gln Glu Ala Ile Gln Gln Leu Asp 
        355                 360                 365             


Ala Glu Leu Arg Asn Thr Lys Trp Glu Met Ala Ala Gln Leu Arg Glu 
    370                 375                 380                 


Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala 
385                 390                 395                 400 


Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Ile Gly Phe Gly 
                405                 410                 415     


Pro Ile Pro Phe Ser Leu Pro Glu Gly Leu Pro Lys Ile Pro Ser Val 
            420                 425                 430         


Ser Thr His Ile Lys Val Lys Ser Glu Glu Lys Ile Lys Val Val Glu 
        435                 440                 445             


Lys Ser Glu Lys Glu Thr Val Ile Val Glu Glu Gln Thr Glu Glu Thr 
    450                 455                 460                 


Gln Val Thr Glu Glu Val Thr Glu Glu Glu Glu Lys Glu Ala Lys Glu 
465                 470                 475                 480 


Glu Glu Gly Lys Glu Glu Glu Gly Gly Glu Glu Glu Glu Ala Glu Gly 
                485                 490                 495     


Gly Glu Glu Glu Thr Lys Ser Pro Pro Ala Glu Glu Ala Ala Ser Pro 
            500                 505                 510         


Glu Lys Glu Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Ala 
        515                 520                 525             


Glu Ala Lys Ser Pro Glu Lys Glu Glu Ala Lys Ser Pro Ala Glu Val 
    530                 535                 540                 


Lys Ser Pro Glu Lys Ala Lys Ser Pro Ala Lys Glu Glu Ala Lys Ser 
545                 550                 555                 560 


Pro Pro Glu Ala Lys Ser Pro Glu Lys Glu Glu Ala Lys Ser Pro Ala 
                565                 570                 575     


Glu Val Lys Ser Pro Glu Lys Ala Lys Ser Pro Ala Lys Glu Glu Ala 
            580                 585                 590         


Lys Ser Pro Ala Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val 
        595                 600                 605             


Lys Glu Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro Val Lys Glu 
    610                 615                 620                 


Glu Ala Lys Ser Pro Ala Glu Val Lys Ser Pro Glu Lys Ala Lys Ser 
625                 630                 635                 640 


Pro Thr Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Glu 
                645                 650                 655     


Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Ala 
            660                 665                 670         


Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Ala Glu Ala 
        675                 680                 685             


Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser 
    690                 695                 700                 


Pro Glu Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Glu 
705                 710                 715                 720 


Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Thr Pro Glu Lys Ala 
                725                 730                 735     


Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser 
            740                 745                 750         


Pro Glu Lys Ala Lys Thr Leu Asp Val Lys Ser Pro Glu Ala Lys Thr 
        755                 760                 765             


Pro Ala Lys Glu Glu Ala Arg Ser Pro Ala Asp Lys Phe Pro Glu Lys 
    770                 775                 780                 


Ala Lys Ser Pro Val Lys Glu Glu Val Lys Ser Pro Glu Lys Ala Lys 
785                 790                 795                 800 


Ser Pro Leu Lys Glu Asp Ala Lys Ala Pro Glu Lys Glu Ile Pro Lys 
                805                 810                 815     


Lys Glu Glu Val Lys Ser Pro Val Lys Glu Glu Glu Lys Pro Gln Glu 
            820                 825                 830         


Val Lys Val Lys Glu Pro Pro Lys Lys Ala Glu Glu Glu Lys Ala Pro 
        835                 840                 845             


Ala Thr Pro Lys Thr Glu Glu Lys Lys Asp Ser Lys Lys Glu Glu Ala 
    850                 855                 860                 


Pro Lys Lys Glu Ala Pro Lys Pro Lys Val Glu Glu Lys Lys Glu Pro 
865                 870                 875                 880 


Ala Val Glu Lys Pro Lys Glu Ser Lys Val Glu Ala Lys Lys Glu Glu 
                885                 890                 895     


Ala Glu Asp Lys Lys Lys Val Pro Thr Pro Glu Lys Glu Ala Pro Ala 
            900                 905                 910         


Lys Val Glu Val Lys Glu Asp Ala Lys Pro Lys Glu Lys Thr Glu Val 
        915                 920                 925             


Ala Lys Lys Glu Pro Asp Asp Ala Lys Ala Lys Glu Pro Ser Lys Pro 
    930                 935                 940                 


Ala Glu Lys Lys Glu Ala Ala Pro Glu Lys Lys Asp Thr Lys Glu Glu 
945                 950                 955                 960 


Lys Ala Lys Lys Pro Glu Glu Lys Pro Lys Thr Glu Ala Lys Ala Lys 
                965                 970                 975     


Glu Asp Asp Lys Thr Leu Ser Lys Glu Pro Ser Lys Pro Lys Ala Glu 
            980                 985                 990         


Lys Ala Glu Lys Ser Ser Ser Thr  Asp Gln Lys Asp Ser  Lys Pro Pro 
        995                 1000                 1005             


Glu Lys  Ala Thr Glu Asp Lys  Ala Ala Lys Gly Lys  
    1010                 1015                 1020 


<210>  317
<211>  6021
<212>  DNA
<213>  Homo sapiens

<400>  317
tattttggca gccttatcca agtctggtac aacatagcaa agagaacagg ctatgaaata     60

agatggcaag aaagaaattt agtggattgg aaatctctct gattgtcctt tttgtcatag    120

ttactataat agctattgcc ttaattgttg ttttagcaac taagacacct gctgttgatg    180

aaattagtga ttctacttca actccagcta ctactcgtgt gactacaaat ccttctgatt    240

caggaaaatg tccaaatgtg ttaaatgatc ctgtcaatgt gagaataaac tgcattccag    300

aacaattccc aacagaggga atttgtgcac agagaggctg ctgctggagg ccgtggaatg    360

actctcttat tccttggtgc ttcttcgttg ataatcatgg ttataacgtt caagacatga    420

caacaacaag tattggagtt gaagccaaat taaacaggat accttcacct acactatttg    480

gaaatgacat caacagtgtt ctcttcacaa ctcaaaatca gacacccaat cgtttccggt    540

tcaagattac tgatccaaat aatagaagat atgaagttcc tcatcagtat gtaaaagagt    600

ttactggacc cacagtttct gatacgttgt atgatgtgaa ggttgcccaa aacccattta    660

gcatccaagt tattaggaaa agcaacggta aaactttgtt tgacaccagc attggtccct    720

tagtgtactc tgaccagtac ttacagatct cagcccgtct tccaagtgat tatatttatg    780

gtattggaga acaagttcat aagagatttc gtcatgattt atcctggaaa acatggccaa    840

tttttactcg agaccaactt cctggtgata ataataataa tttatacggc catcaaacat    900

tctttatgtg tattgaagat acatctggaa agtcattcgg tgttttttta atgaatagca    960

atgcaatgga gatttttatc cagcctactc caatagtaac atatagagtt accggtggca   1020

ttctggattt ttacatcctt ctaggagata caccagaaca agtagttcaa cagtatcaac   1080

agcttgttgg actaccagca atgccagcat attggaatct tggattccaa ctaagtcgct   1140

ggaattataa gtcactagat gtagtgaaag aagtggtaag gagaaaccgg gaagctggca   1200

taccatttga tacacaggtc actgatattg actacatgga agacaagaaa gactttactt   1260

atgatcaagt tgcgtttaac ggactccctc aatttgtgca agatttgcat gaccatggac   1320

agaaatatgt catcatcttg gaccctgcaa tttccatagg tcgacgtgcc aatggaacaa   1380

catatgcaac ctatgagagg ggaaacacac aacatgtgtg gataaatgag tcagatggaa   1440

gtacaccaat tattggagag gtatggccag gattaacagt ataccctgat ttcactaatc   1500

caaactgcat tgattggtgg gcaaatgaat gcagtatttt ccatcaagaa gtgcaatatg   1560

atggactttg gattgacatg aatgaagttt ccagctttat tcaaggttca acaaaaggat   1620

gtaatgtaaa caaattgaat tatccaccgt ttactcctga tattcttgac aaactcatgt   1680

attccaaaac aatttgcatg gatgctgtgc agaactgggg taaacagtat gatgttcata   1740

gcctctatgg atacagcatg gctatagcca cagagcaagc tgtacaaaaa gtttttccta   1800

ataagagaag cttcattctt acccgctcaa catttgctgg atctggaaga catgctgctc   1860

attggttagg agacaatact gcttcatggg aacaaatgga atggtctata actggaatgc   1920

tggagttcag tttgtttgga atacctttgg ttggagcaga catctgtgga tttgtggctg   1980

aaaccacaga agaactttgc agaagatgga tgcaacttgg ggcattttat ccattttcca   2040

gaaaccataa ttctgacgga tatgaacatc aggatcctgc attttttggg cagaattcac   2100

ttttggttaa atcatcaagg cagtatttaa ctattcgcta caccttatta cccttcctct   2160

acactctgtt ttataaagcc catgtgtttg gagaaacagt agcaagacca gttcttcatg   2220

agttttatga ggatacgaac agctggattg aggacactga gtttttgtgg ggccctgcat   2280

tacttattac tcctgttcta aaacagggag cagatactgt gagtgcctac atccctgatg   2340

ctatttggta tgattatgaa tctggtgcaa aaaggccatg gaggaaacaa cgggttgata   2400

tgtatcttcc agcagacaaa ataggattac atcttagagg aggttatatc atccccattc   2460

aagaaccaga tgtaacaaca acagcaagcc gtaagaatcc tctaggactt atagtcgcat   2520

taggtgaaaa caacacagcc aaaggagact ttttctggga tgatggagaa actaaagata   2580

caatacaaaa tggcaactac atattatata cattttcagt ttctaataac acattagata   2640

ttgtgtgcac acattcatca tatcaggaag gaactacctt agcatttcag actgtaaaaa   2700

tccttgggtt gacagacagt gttacagaag ttagagtggc ggaaaataat caaccaatga   2760

acgctcattc caatttcact tatgatgctt ctaaccaggt tctcctaatt gcagatctca   2820

aacttaatct tggaagaaac tttagtgttc aatggaatca aattttctca gaaaatgaaa   2880

gatttaattg ttatccagat gcagatttgg caactgaaca aaagtgcaca caacgtggct   2940

gtgtatggag aacgggttct tctctatcca aagcacctga gtgttacttt cccagacaag   3000

ataactctta ttcagtcaac tcagctcgct attcatccat gggtataaca gctgacctcc   3060

aactaaatac tgcaaatgcc agaataaagt taccttctga ccccatctca actcttcgtg   3120

tggaggtgaa atatcacaaa aatgatatgt tgcagtttaa gatttatgat ccccaaaaga   3180

agagatatga agtaccagta ccgttaaaca ttccaaccac cccaataagt acttatgaag   3240

acagacttta tgatgtggaa atcaaggaaa atccttttgg catccagatt cgacggagaa   3300

gcagtggaag agtcatttgg gattcttggc tgcctggatt tgcttttaat gaccagttca   3360

ttcaaatatc gactcgcctg ccatcagaat atatatatgg ttttggggaa gtggaacata   3420

cagcatttaa gcgagatctg aactggaata cttggggaat gttcacaaga gaccaacccc   3480

ctggttacaa acttaattcc tatggatttc atccctatta catggctctg gaagaggagg   3540

gcaatgctca tggtgttttc ttactcaaca gcaatgcaat ggatgttaca ttccagccaa   3600

ctcctgctct aacttaccgt acagttggag ggatcttgga tttttatatg tttttgggcc   3660

caactccaca agttgcaaca aagcaatacc atgaagtaat tggccatcca gtcatgccag   3720

cttattgggc tttgggattc caattatgtc gttatggata tgcaaatact tcagaggttc   3780

gggaattata tgacgctatg gtggctgcta acatccccta tgatgttcag tacacagaca   3840

ttgactacat ggaaaggcag ctagacttta caattggtga agcattccag gaccttcctc   3900

agtttgttga caaaataaga ggagaaggaa tgagatacat tattatcctg gatccagcaa   3960

tttcaggaaa tgaaacaaag acttaccctg catttgaaag aggacagcag aatgatgtct   4020

ttgtcaaatg gccaaacacc aatgacattt gttgggcaaa ggtttggcca gatttgccca   4080

acataacaat agataaaact ctaacggaag atgaagctgt taatgcttcc agagctcatg   4140

tagctttccc agatttcttc aggacttcca cagcagagtg gtgggccaga gaaattgtgg   4200

acttttacaa tgaaaagatg aagtttgatg gtttgtggat tgatatgaat gagccatcaa   4260

gttttgtaaa tggaacaact actaatcaat gcagaaatga cgaactaaat tatccacctt   4320

atttcccaga actcacaaaa agaactgatg gattacattt cagaacaatt tgcatggaag   4380

ctgagcagat tcttagtgat ggaacatcag ttttgcatta cgatgttcac aatctctatg   4440

gatggtcaca gatgaaacct actcatgatg cattgcaaaa gacaactgga aaaagaggga   4500

ttgtaatttc tcgttccacg tatcctacta gtggacgatg gggaggacac tggcttggag   4560

acaactatgc acgatgggac aacatggaca aatcaatcat tggtatgatg gaatttagtc   4620

tgtttggaat atcatatact ggagcagaca tctgtggttt tttcaacaac tcagaatatc   4680

atctctgtac ccgctggatg caacttggag cattttatcc atactcaagg aatcacaaca   4740

ttgcaaatac tagaagacaa gatcccgctt cctggaatga aacttttgct gaaatgtcaa   4800

ggaatattct aaatattaga tacaccttat tgccctattt ttacacacaa atgcatgaaa   4860

ttcatgctaa tggtggcact gttatccgac cccttttgca tgagttcttt gatgaaaaac   4920

caacctggga tatattcaag cagttcttat ggggtccagc atttatggtt accccagtac   4980

tggaacctta tgttcaaact gtaaatgcct acgtccccaa tgctcggtgg tttgactacc   5040

atacaggcaa agatattggc gtcagaggac aatttcaaac atttaatgct tcttatgaca   5100

caataaacct acatgtccgt ggtggtcaca tcctaccatg tcaagagcca gctcaaaaca   5160

cattttacag tcgacaaaaa cacatgaagc tcattgttgc tgcagatgat aatcagatgg   5220

cacagggttc tctgttttgg gatgatggag agagtataga cacctatgaa agagacctat   5280

atttatctgt acaatttaat ttaaaccaga ccaccttaac aagcactata ttgaagagag   5340

gttacataaa taaaagtgaa acgaggcttg gatcccttca tgtatggggg aaaggaacta   5400

ctcctgtcaa tgcagttact ctaacgtata acggaaataa aaattcgctt ccttttaatg   5460

aagacactac caacatgata ttacgtattg atctgaccac acacaatgtt actctagaag   5520

aaccaataga aatcaactgg tcatgaagat caccatcaat tttagttgtc aatgggaaaa   5580

aacaccagga tttaagtttc acagcactta caattttccc tcttcacttg gttcttgtac   5640

tctacaaaat atagctttca taacatcgaa aagttatttt gtagcgtaca tcaatgataa   5700

tgctaatttt attatagtaa tgtgacttgg attcaatttt aaggcatatt taacaaaatt   5760

tgaatagccc tatttatcct tgttaagtat cagctacaat tgtaaactag ttactaaaca   5820

tgtatgtaaa tagctaagat ataatttaaa cgtgattttt aaattaaata aaatttttat   5880

gtaattatat atactatatt tttctcaatg tttagcagat ttaagatatg taacaacaat   5940

tatttgaaga tttaattact tcttagtatg tgcatttaat tagaaaaaga gaataaaaaa   6000

tgtaagtgta aaaaaaaaaa a                                             6021


<210>  318
<211>  1827
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Ala Arg Lys Lys Phe Ser Gly Leu Glu Ile Ser Leu Ile Val Leu 
1               5                   10                  15      


Phe Val Ile Val Thr Ile Ile Ala Ile Ala Leu Ile Val Val Leu Ala 
            20                  25                  30          


Thr Lys Thr Pro Ala Val Asp Glu Ile Ser Asp Ser Thr Ser Thr Pro 
        35                  40                  45              


Ala Thr Thr Arg Val Thr Thr Asn Pro Ser Asp Ser Gly Lys Cys Pro 
    50                  55                  60                  


Asn Val Leu Asn Asp Pro Val Asn Val Arg Ile Asn Cys Ile Pro Glu 
65                  70                  75                  80  


Gln Phe Pro Thr Glu Gly Ile Cys Ala Gln Arg Gly Cys Cys Trp Arg 
                85                  90                  95      


Pro Trp Asn Asp Ser Leu Ile Pro Trp Cys Phe Phe Val Asp Asn His 
            100                 105                 110         


Gly Tyr Asn Val Gln Asp Met Thr Thr Thr Ser Ile Gly Val Glu Ala 
        115                 120                 125             


Lys Leu Asn Arg Ile Pro Ser Pro Thr Leu Phe Gly Asn Asp Ile Asn 
    130                 135                 140                 


Ser Val Leu Phe Thr Thr Gln Asn Gln Thr Pro Asn Arg Phe Arg Phe 
145                 150                 155                 160 


Lys Ile Thr Asp Pro Asn Asn Arg Arg Tyr Glu Val Pro His Gln Tyr 
                165                 170                 175     


Val Lys Glu Phe Thr Gly Pro Thr Val Ser Asp Thr Leu Tyr Asp Val 
            180                 185                 190         


Lys Val Ala Gln Asn Pro Phe Ser Ile Gln Val Ile Arg Lys Ser Asn 
        195                 200                 205             


Gly Lys Thr Leu Phe Asp Thr Ser Ile Gly Pro Leu Val Tyr Ser Asp 
    210                 215                 220                 


Gln Tyr Leu Gln Ile Ser Ala Arg Leu Pro Ser Asp Tyr Ile Tyr Gly 
225                 230                 235                 240 


Ile Gly Glu Gln Val His Lys Arg Phe Arg His Asp Leu Ser Trp Lys 
                245                 250                 255     


Thr Trp Pro Ile Phe Thr Arg Asp Gln Leu Pro Gly Asp Asn Asn Asn 
            260                 265                 270         


Asn Leu Tyr Gly His Gln Thr Phe Phe Met Cys Ile Glu Asp Thr Ser 
        275                 280                 285             


Gly Lys Ser Phe Gly Val Phe Leu Met Asn Ser Asn Ala Met Glu Ile 
    290                 295                 300                 


Phe Ile Gln Pro Thr Pro Ile Val Thr Tyr Arg Val Thr Gly Gly Ile 
305                 310                 315                 320 


Leu Asp Phe Tyr Ile Leu Leu Gly Asp Thr Pro Glu Gln Val Val Gln 
                325                 330                 335     


Gln Tyr Gln Gln Leu Val Gly Leu Pro Ala Met Pro Ala Tyr Trp Asn 
            340                 345                 350         


Leu Gly Phe Gln Leu Ser Arg Trp Asn Tyr Lys Ser Leu Asp Val Val 
        355                 360                 365             


Lys Glu Val Val Arg Arg Asn Arg Glu Ala Gly Ile Pro Phe Asp Thr 
    370                 375                 380                 


Gln Val Thr Asp Ile Asp Tyr Met Glu Asp Lys Lys Asp Phe Thr Tyr 
385                 390                 395                 400 


Asp Gln Val Ala Phe Asn Gly Leu Pro Gln Phe Val Gln Asp Leu His 
                405                 410                 415     


Asp His Gly Gln Lys Tyr Val Ile Ile Leu Asp Pro Ala Ile Ser Ile 
            420                 425                 430         


Gly Arg Arg Ala Asn Gly Thr Thr Tyr Ala Thr Tyr Glu Arg Gly Asn 
        435                 440                 445             


Thr Gln His Val Trp Ile Asn Glu Ser Asp Gly Ser Thr Pro Ile Ile 
    450                 455                 460                 


Gly Glu Val Trp Pro Gly Leu Thr Val Tyr Pro Asp Phe Thr Asn Pro 
465                 470                 475                 480 


Asn Cys Ile Asp Trp Trp Ala Asn Glu Cys Ser Ile Phe His Gln Glu 
                485                 490                 495     


Val Gln Tyr Asp Gly Leu Trp Ile Asp Met Asn Glu Val Ser Ser Phe 
            500                 505                 510         


Ile Gln Gly Ser Thr Lys Gly Cys Asn Val Asn Lys Leu Asn Tyr Pro 
        515                 520                 525             


Pro Phe Thr Pro Asp Ile Leu Asp Lys Leu Met Tyr Ser Lys Thr Ile 
    530                 535                 540                 


Cys Met Asp Ala Val Gln Asn Trp Gly Lys Gln Tyr Asp Val His Ser 
545                 550                 555                 560 


Leu Tyr Gly Tyr Ser Met Ala Ile Ala Thr Glu Gln Ala Val Gln Lys 
                565                 570                 575     


Val Phe Pro Asn Lys Arg Ser Phe Ile Leu Thr Arg Ser Thr Phe Ala 
            580                 585                 590         


Gly Ser Gly Arg His Ala Ala His Trp Leu Gly Asp Asn Thr Ala Ser 
        595                 600                 605             


Trp Glu Gln Met Glu Trp Ser Ile Thr Gly Met Leu Glu Phe Ser Leu 
    610                 615                 620                 


Phe Gly Ile Pro Leu Val Gly Ala Asp Ile Cys Gly Phe Val Ala Glu 
625                 630                 635                 640 


Thr Thr Glu Glu Leu Cys Arg Arg Trp Met Gln Leu Gly Ala Phe Tyr 
                645                 650                 655     


Pro Phe Ser Arg Asn His Asn Ser Asp Gly Tyr Glu His Gln Asp Pro 
            660                 665                 670         


Ala Phe Phe Gly Gln Asn Ser Leu Leu Val Lys Ser Ser Arg Gln Tyr 
        675                 680                 685             


Leu Thr Ile Arg Tyr Thr Leu Leu Pro Phe Leu Tyr Thr Leu Phe Tyr 
    690                 695                 700                 


Lys Ala His Val Phe Gly Glu Thr Val Ala Arg Pro Val Leu His Glu 
705                 710                 715                 720 


Phe Tyr Glu Asp Thr Asn Ser Trp Ile Glu Asp Thr Glu Phe Leu Trp 
                725                 730                 735     


Gly Pro Ala Leu Leu Ile Thr Pro Val Leu Lys Gln Gly Ala Asp Thr 
            740                 745                 750         


Val Ser Ala Tyr Ile Pro Asp Ala Ile Trp Tyr Asp Tyr Glu Ser Gly 
        755                 760                 765             


Ala Lys Arg Pro Trp Arg Lys Gln Arg Val Asp Met Tyr Leu Pro Ala 
    770                 775                 780                 


Asp Lys Ile Gly Leu His Leu Arg Gly Gly Tyr Ile Ile Pro Ile Gln 
785                 790                 795                 800 


Glu Pro Asp Val Thr Thr Thr Ala Ser Arg Lys Asn Pro Leu Gly Leu 
                805                 810                 815     


Ile Val Ala Leu Gly Glu Asn Asn Thr Ala Lys Gly Asp Phe Phe Trp 
            820                 825                 830         


Asp Asp Gly Glu Thr Lys Asp Thr Ile Gln Asn Gly Asn Tyr Ile Leu 
        835                 840                 845             


Tyr Thr Phe Ser Val Ser Asn Asn Thr Leu Asp Ile Val Cys Thr His 
    850                 855                 860                 


Ser Ser Tyr Gln Glu Gly Thr Thr Leu Ala Phe Gln Thr Val Lys Ile 
865                 870                 875                 880 


Leu Gly Leu Thr Asp Ser Val Thr Glu Val Arg Val Ala Glu Asn Asn 
                885                 890                 895     


Gln Pro Met Asn Ala His Ser Asn Phe Thr Tyr Asp Ala Ser Asn Gln 
            900                 905                 910         


Val Leu Leu Ile Ala Asp Leu Lys Leu Asn Leu Gly Arg Asn Phe Ser 
        915                 920                 925             


Val Gln Trp Asn Gln Ile Phe Ser Glu Asn Glu Arg Phe Asn Cys Tyr 
    930                 935                 940                 


Pro Asp Ala Asp Leu Ala Thr Glu Gln Lys Cys Thr Gln Arg Gly Cys 
945                 950                 955                 960 


Val Trp Arg Thr Gly Ser Ser Leu Ser Lys Ala Pro Glu Cys Tyr Phe 
                965                 970                 975     


Pro Arg Gln Asp Asn Ser Tyr Ser Val Asn Ser Ala Arg Tyr Ser Ser 
            980                 985                 990         


Met Gly Ile Thr Ala Asp Leu Gln  Leu Asn Thr Ala Asn  Ala Arg Ile 
        995                 1000                 1005             


Lys Leu  Pro Ser Asp Pro Ile  Ser Thr Leu Arg Val  Glu Val Lys 
    1010                 1015                 1020             


Tyr His  Lys Asn Asp Met Leu  Gln Phe Lys Ile Tyr  Asp Pro Gln 
    1025                 1030                 1035             


Lys Lys  Arg Tyr Glu Val Pro  Val Pro Leu Asn Ile  Pro Thr Thr 
    1040                 1045                 1050             


Pro Ile  Ser Thr Tyr Glu Asp  Arg Leu Tyr Asp Val  Glu Ile Lys 
    1055                 1060                 1065             


Glu Asn  Pro Phe Gly Ile Gln  Ile Arg Arg Arg Ser  Ser Gly Arg 
    1070                 1075                 1080             


Val Ile  Trp Asp Ser Trp Leu  Pro Gly Phe Ala Phe  Asn Asp Gln 
    1085                 1090                 1095             


Phe Ile  Gln Ile Ser Thr Arg  Leu Pro Ser Glu Tyr  Ile Tyr Gly 
    1100                 1105                 1110             


Phe Gly  Glu Val Glu His Thr  Ala Phe Lys Arg Asp  Leu Asn Trp 
    1115                 1120                 1125             


Asn Thr  Trp Gly Met Phe Thr  Arg Asp Gln Pro Pro  Gly Tyr Lys 
    1130                 1135                 1140             


Leu Asn  Ser Tyr Gly Phe His  Pro Tyr Tyr Met Ala  Leu Glu Glu 
    1145                 1150                 1155             


Glu Gly  Asn Ala His Gly Val  Phe Leu Leu Asn Ser  Asn Ala Met 
    1160                 1165                 1170             


Asp Val  Thr Phe Gln Pro Thr  Pro Ala Leu Thr Tyr  Arg Thr Val 
    1175                 1180                 1185             


Gly Gly  Ile Leu Asp Phe Tyr  Met Phe Leu Gly Pro  Thr Pro Gln 
    1190                 1195                 1200             


Val Ala  Thr Lys Gln Tyr His  Glu Val Ile Gly His  Pro Val Met 
    1205                 1210                 1215             


Pro Ala  Tyr Trp Ala Leu Gly  Phe Gln Leu Cys Arg  Tyr Gly Tyr 
    1220                 1225                 1230             


Ala Asn  Thr Ser Glu Val Arg  Glu Leu Tyr Asp Ala  Met Val Ala 
    1235                 1240                 1245             


Ala Asn  Ile Pro Tyr Asp Val  Gln Tyr Thr Asp Ile  Asp Tyr Met 
    1250                 1255                 1260             


Glu Arg  Gln Leu Asp Phe Thr  Ile Gly Glu Ala Phe  Gln Asp Leu 
    1265                 1270                 1275             


Pro Gln  Phe Val Asp Lys Ile  Arg Gly Glu Gly Met  Arg Tyr Ile 
    1280                 1285                 1290             


Ile Ile  Leu Asp Pro Ala Ile  Ser Gly Asn Glu Thr  Lys Thr Tyr 
    1295                 1300                 1305             


Pro Ala  Phe Glu Arg Gly Gln  Gln Asn Asp Val Phe  Val Lys Trp 
    1310                 1315                 1320             


Pro Asn  Thr Asn Asp Ile Cys  Trp Ala Lys Val Trp  Pro Asp Leu 
    1325                 1330                 1335             


Pro Asn  Ile Thr Ile Asp Lys  Thr Leu Thr Glu Asp  Glu Ala Val 
    1340                 1345                 1350             


Asn Ala  Ser Arg Ala His Val  Ala Phe Pro Asp Phe  Phe Arg Thr 
    1355                 1360                 1365             


Ser Thr  Ala Glu Trp Trp Ala  Arg Glu Ile Val Asp  Phe Tyr Asn 
    1370                 1375                 1380             


Glu Lys  Met Lys Phe Asp Gly  Leu Trp Ile Asp Met  Asn Glu Pro 
    1385                 1390                 1395             


Ser Ser  Phe Val Asn Gly Thr  Thr Thr Asn Gln Cys  Arg Asn Asp 
    1400                 1405                 1410             


Glu Leu  Asn Tyr Pro Pro Tyr  Phe Pro Glu Leu Thr  Lys Arg Thr 
    1415                 1420                 1425             


Asp Gly  Leu His Phe Arg Thr  Ile Cys Met Glu Ala  Glu Gln Ile 
    1430                 1435                 1440             


Leu Ser  Asp Gly Thr Ser Val  Leu His Tyr Asp Val  His Asn Leu 
    1445                 1450                 1455             


Tyr Gly  Trp Ser Gln Met Lys  Pro Thr His Asp Ala  Leu Gln Lys 
    1460                 1465                 1470             


Thr Thr  Gly Lys Arg Gly Ile  Val Ile Ser Arg Ser  Thr Tyr Pro 
    1475                 1480                 1485             


Thr Ser  Gly Arg Trp Gly Gly  His Trp Leu Gly Asp  Asn Tyr Ala 
    1490                 1495                 1500             


Arg Trp  Asp Asn Met Asp Lys  Ser Ile Ile Gly Met  Met Glu Phe 
    1505                 1510                 1515             


Ser Leu  Phe Gly Ile Ser Tyr  Thr Gly Ala Asp Ile  Cys Gly Phe 
    1520                 1525                 1530             


Phe Asn  Asn Ser Glu Tyr His  Leu Cys Thr Arg Trp  Met Gln Leu 
    1535                 1540                 1545             


Gly Ala  Phe Tyr Pro Tyr Ser  Arg Asn His Asn Ile  Ala Asn Thr 
    1550                 1555                 1560             


Arg Arg  Gln Asp Pro Ala Ser  Trp Asn Glu Thr Phe  Ala Glu Met 
    1565                 1570                 1575             


Ser Arg  Asn Ile Leu Asn Ile  Arg Tyr Thr Leu Leu  Pro Tyr Phe 
    1580                 1585                 1590             


Tyr Thr  Gln Met His Glu Ile  His Ala Asn Gly Gly  Thr Val Ile 
    1595                 1600                 1605             


Arg Pro  Leu Leu His Glu Phe  Phe Asp Glu Lys Pro  Thr Trp Asp 
    1610                 1615                 1620             


Ile Phe  Lys Gln Phe Leu Trp  Gly Pro Ala Phe Met  Val Thr Pro 
    1625                 1630                 1635             


Val Leu  Glu Pro Tyr Val Gln  Thr Val Asn Ala Tyr  Val Pro Asn 
    1640                 1645                 1650             


Ala Arg  Trp Phe Asp Tyr His  Thr Gly Lys Asp Ile  Gly Val Arg 
    1655                 1660                 1665             


Gly Gln  Phe Gln Thr Phe Asn  Ala Ser Tyr Asp Thr  Ile Asn Leu 
    1670                 1675                 1680             


His Val  Arg Gly Gly His Ile  Leu Pro Cys Gln Glu  Pro Ala Gln 
    1685                 1690                 1695             


Asn Thr  Phe Tyr Ser Arg Gln  Lys His Met Lys Leu  Ile Val Ala 
    1700                 1705                 1710             


Ala Asp  Asp Asn Gln Met Ala  Gln Gly Ser Leu Phe  Trp Asp Asp 
    1715                 1720                 1725             


Gly Glu  Ser Ile Asp Thr Tyr  Glu Arg Asp Leu Tyr  Leu Ser Val 
    1730                 1735                 1740             


Gln Phe  Asn Leu Asn Gln Thr  Thr Leu Thr Ser Thr  Ile Leu Lys 
    1745                 1750                 1755             


Arg Gly  Tyr Ile Asn Lys Ser  Glu Thr Arg Leu Gly  Ser Leu His 
    1760                 1765                 1770             


Val Trp  Gly Lys Gly Thr Thr  Pro Val Asn Ala Val  Thr Leu Thr 
    1775                 1780                 1785             


Tyr Asn  Gly Asn Lys Asn Ser  Leu Pro Phe Asn Glu  Asp Thr Thr 
    1790                 1795                 1800             


Asn Met  Ile Leu Arg Ile Asp  Leu Thr Thr His Asn  Val Thr Leu 
    1805                 1810                 1815             


Glu Glu  Pro Ile Glu Ile Asn  Trp Ser 
    1820                 1825         


<210>  319
<211>  2093
<212>  DNA
<213>  Homo sapiens

<400>  319
agcagcaact ggaaaacaag cattgcattg catcaggatg tctatgaaat ggacttcagc     60

tcttctgctg atacagctga gctgttactt tagctctggg agttgtggaa aggtgctggt    120

gtggcccaca gaattcagcc actggatgaa tataaagaca atcctggatg aacttgtcca    180

gagaggtcat gaggtgactg tattggcatc ttcagcttcc atttctttcg atcccaacag    240

cccatctact cttaaatttg aagtttatcc tgtatcttta actaaaactg agtttgagga    300

tattatcaag cagctggtta agagatgggc agaacttcca aaagacacat tttggtcata    360

tttttcacaa gtacaagaaa tcatgtggac atttaatgac atacttagaa agttctgtaa    420

ggatatagtt tcaaataaga aacttatgaa gaaactacag gagtcaagat ttgatgttgt    480

tcttgcagat gctgttttcc cctttggtga gctgctggcc gagttactta aaataccctt    540

tgtctacagg cctcgcttct ctcctggcta cgcaattgaa aagcatagtg gaggacttct    600

gttccctcct tcctatgtgc ctgttgttat gtcagaacta agtgaccaaa tgactttcat    660

agagagggta aaaaatatga tctatgtgct ttattttgaa ttttggttcc aaatatttga    720

catgaagaag tgggatcagt tctacagtga agttctagga agacccacta cgttatctga    780

gacaatggca aaagctgaca tatggcttat tcgaaactac tgggattttc aatttcctca    840

cccactctta ccaaatgttg agttcgttgg aggactccac tgcaaacctg ccaaacccct    900

accgaaggaa atggaagagt ttgtccagag ctctggagaa aatggtgttg tggtgttttc    960

tctggggtcg atggtcagta acacgtcaga agaaagggcc aatgtaattg catcagccct   1020

tgccaagatc ccacaaaagg ttctgtggag atttgatggg aataaaccag atactttagg   1080

actcaatact cggctgtaca agtggatacc ccagaatgat cttcttggtc acccaaaaac   1140

cagagctttt ataactcatg gtggagccaa tggcatctat aaggcaatct ctcctagaat   1200

ccctatggtg ggcgttccat tgtttgcaga tcaacctgat aacattgcac acatgaaggc   1260

caagggagca gctgttagtt tggacttcca cacaatgtcg agtacagact tactcaatgc   1320

actgaagaca gtaattaatg atcctttata taaagagaat gctatgaaat tatcaagaat   1380

tcatcatgat caaccagtga agccccttga tcgagcagtc ttctggattg aatttgtcat   1440

gcgccataaa ggagccaagc accttcgggt tgcagcccac gacctcacct ggttccagta   1500

ccactctttg gatgtgactg ggttcctgct ggcctgtgtg gcaactgtga tattcatcat   1560

cacaaaatgt ctgttttgtg tctggaagtt tgttagaaca ggaaagaagg ggaaaagaga   1620

ttaattacgt ctgaggctgg aagctgggaa acccaataaa tgaactcctt tagtttatta   1680

caacaagaag acgttgtgat acaagagatt cctttcttct tgtgacaaaa catctttcaa   1740

aacttacctt gtcaagtcaa aatttgtttt agtacctgtt taaccattag aaatatttca   1800

tgtcaaggag gaaaacatta gggaaaacaa aaatgatata aagccatatg aggttatatt   1860

gaaatgtatt gagcttatat tgaaatttat tgttccaatt cacaggttac atgaaaaaaa   1920

atttactaag cttaactaca tgtcacacat tgtacatgga aacaagaaca ttaagaagtc   1980

cgactgacag tatcagtact gttttgcaaa tactcagcat actttggatc catttcatgc   2040

aggattgtgt tgttttaact gttgttgagg aagctaataa ataattaaat tgt          2093


<210>  320
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Ser Met Lys Trp Thr Ser Ala Leu Leu Leu Ile Gln Leu Ser Cys 
1               5                   10                  15      


Tyr Phe Ser Ser Gly Ser Cys Gly Lys Val Leu Val Trp Pro Thr Glu 
            20                  25                  30          


Phe Ser His Trp Met Asn Ile Lys Thr Ile Leu Asp Glu Leu Val Gln 
        35                  40                  45              


Arg Gly His Glu Val Thr Val Leu Ala Ser Ser Ala Ser Ile Ser Phe 
    50                  55                  60                  


Asp Pro Asn Ser Pro Ser Thr Leu Lys Phe Glu Val Tyr Pro Val Ser 
65                  70                  75                  80  


Leu Thr Lys Thr Glu Phe Glu Asp Ile Ile Lys Gln Leu Val Lys Arg 
                85                  90                  95      


Trp Ala Glu Leu Pro Lys Asp Thr Phe Trp Ser Tyr Phe Ser Gln Val 
            100                 105                 110         


Gln Glu Ile Met Trp Thr Phe Asn Asp Ile Leu Arg Lys Phe Cys Lys 
        115                 120                 125             


Asp Ile Val Ser Asn Lys Lys Leu Met Lys Lys Leu Gln Glu Ser Arg 
    130                 135                 140                 


Phe Asp Val Val Leu Ala Asp Ala Val Phe Pro Phe Gly Glu Leu Leu 
145                 150                 155                 160 


Ala Glu Leu Leu Lys Ile Pro Phe Val Tyr Arg Pro Arg Phe Ser Pro 
                165                 170                 175     


Gly Tyr Ala Ile Glu Lys His Ser Gly Gly Leu Leu Phe Pro Pro Ser 
            180                 185                 190         


Tyr Val Pro Val Val Met Ser Glu Leu Ser Asp Gln Met Thr Phe Ile 
        195                 200                 205             


Glu Arg Val Lys Asn Met Ile Tyr Val Leu Tyr Phe Glu Phe Trp Phe 
    210                 215                 220                 


Gln Ile Phe Asp Met Lys Lys Trp Asp Gln Phe Tyr Ser Glu Val Leu 
225                 230                 235                 240 


Gly Arg Pro Thr Thr Leu Ser Glu Thr Met Ala Lys Ala Asp Ile Trp 
                245                 250                 255     


Leu Ile Arg Asn Tyr Trp Asp Phe Gln Phe Pro His Pro Leu Leu Pro 
            260                 265                 270         


Asn Val Glu Phe Val Gly Gly Leu His Cys Lys Pro Ala Lys Pro Leu 
        275                 280                 285             


Pro Lys Glu Met Glu Glu Phe Val Gln Ser Ser Gly Glu Asn Gly Val 
    290                 295                 300                 


Val Val Phe Ser Leu Gly Ser Met Val Ser Asn Thr Ser Glu Glu Arg 
305                 310                 315                 320 


Ala Asn Val Ile Ala Ser Ala Leu Ala Lys Ile Pro Gln Lys Val Leu 
                325                 330                 335     


Trp Arg Phe Asp Gly Asn Lys Pro Asp Thr Leu Gly Leu Asn Thr Arg 
            340                 345                 350         


Leu Tyr Lys Trp Ile Pro Gln Asn Asp Leu Leu Gly His Pro Lys Thr 
        355                 360                 365             


Arg Ala Phe Ile Thr His Gly Gly Ala Asn Gly Ile Tyr Lys Ala Ile 
    370                 375                 380                 


Ser Pro Arg Ile Pro Met Val Gly Val Pro Leu Phe Ala Asp Gln Pro 
385                 390                 395                 400 


Asp Asn Ile Ala His Met Lys Ala Lys Gly Ala Ala Val Ser Leu Asp 
                405                 410                 415     


Phe His Thr Met Ser Ser Thr Asp Leu Leu Asn Ala Leu Lys Thr Val 
            420                 425                 430         


Ile Asn Asp Pro Leu Tyr Lys Glu Asn Ala Met Lys Leu Ser Arg Ile 
        435                 440                 445             


His His Asp Gln Pro Val Lys Pro Leu Asp Arg Ala Val Phe Trp Ile 
    450                 455                 460                 


Glu Phe Val Met Arg His Lys Gly Ala Lys His Leu Arg Val Ala Ala 
465                 470                 475                 480 


His Asp Leu Thr Trp Phe Gln Tyr His Ser Leu Asp Val Thr Gly Phe 
                485                 490                 495     


Leu Leu Ala Cys Val Ala Thr Val Ile Phe Ile Ile Thr Lys Cys Leu 
            500                 505                 510         


Phe Cys Val Trp Lys Phe Val Arg Thr Gly Lys Lys Gly Lys Arg Asp 
        515                 520                 525             


<210>  321
<211>  4884
<212>  DNA
<213>  Homo sapiens

<400>  321
cggcgcgttg cggcaggtgc cctgggcgta ctgaggcgcg gtggcctgag cccggccgcc     60

atcgatgacc ccggtcgcgg acttgcttca ggctggccac cccccgtctt gtttcatcat    120

ctgtgttgag taaccatggg gaggaagctg gacctgtctg gtttgactga tgatgaaaca    180

gagcatgttc ttcaggtggt tcaaagagac ttcaatcttc gcaaaaaaga agaagaacga    240

ctaagtgagc tgaagcagaa gctggatgag gaaggcagca agtgcagcat cctctcgaag    300

caccagcagt ttgtggagca ctgctgcatg cgctgctgct cgcccttcac cttcctcgtc    360

aacaccaagc gccagtgtgg agattgcaaa ttcaatgtct gcaagagctg ctgctcctac    420

cagaagcacg aaaaggcctg ggtctgctgc gtctgccagc aagcgaggct tctgagggcc    480

caatctctgg aatggttcta caataatgtg aagagccgct tcaagcgctt tggcagtgcc    540

aaggttctga agaacctgta caggaagcac cggctggaga gtggcgcgtg cttcgacatt    600

ctaggaggaa gcctttttga gtcaaacctg gagaatgaag gaagcatttc tggcagtgat    660

tcaacatttt ataggcagtc agaaggacat agtgtgatgg acaccttggc tgtggcccta    720

cgggtggctg aagaggccat tgaggaagca atttccaaag cagaggcata tggggacagc    780

ctggacaagc aaaatgaggc cagttacctg cgggaccaca aggaggagct aactgaggaa    840

ctggccacga caatcctgca gaagattata cgaaaacaga agagcaaaag tgagcagcaa    900

gtggaagaag agccaggatg gccacatccc cagagttgca gcacaaaggt ggcagatgag    960

gggacctcag catcccctgg aggctaccgt gctcccgctg ccctctggag gtcccagtct   1020

gccttctcaa tcactggaga agaagccctg aagacccctc cagtggaggc tccatcgagg   1080

cagccaaggg accaaggcca acacccgaga gcagagtctg ctctgcccag ctggaagagt   1140

gtggacaggc tggatgaaac aaacctggcc ccagttttgc agagccccga cgggaactgg   1200

gtggccctga aggatggcgc tccacccccc acccgactac tggccaaacc taagagcggg   1260

acgtttcagg ccctggaggt ggcctccagt gtggcatctg cctacgatga gatgggctcc   1320

gatagcgagg aagactttga ctggagtgag gccttgagca agctgtgtcc caggtcccgg   1380

gccctgccca ggaaccccca gcctcagccc acacaggccc agagctctga ccaaggcccc   1440

atagctgcct ccccatcctc tgcactctcc cccaaccctg aggccatgtg ctctgactcg   1500

gagacctcct ccgcaggctc ttcccgagaa gttgggcacc aggccagact gtcctggttg   1560

cagaggaagg cccccaggaa ccctgcagct gagaagatgc gcttgcatgg agagctggac   1620

gtgaacttca acccccagtt ggccagcagg gagacctcgg acagcagcga gccggaggag   1680

gccccccaca ccacagaccg gcgggccagg aggtggagaa gagcccgact gggctcagaa   1740

gagccaagca aagaaccatc ttcccccagc gcccagctcc gggatctaga cacacatcag   1800

gtgtcggatg atttatcaga gacagacatc agcaatgagg ctcgggatcc ccagactctc   1860

acagacacca cagaggagaa acggagaaac aggctgtacg agttagcaat gaaaatgagt   1920

gaaaaggaga cttcttcagg ggaggatcag gagtctgagc ccaagacaga atctgagaac   1980

cagaaggaaa gtctgtcctc tgaagacaac agccagagtg tccaggaaga gctgaagaag   2040

aagttttctg ctgtttctct ctgcaacatc tccacagaag tcctgaaagt catcaatgcc   2100

acagaggagt tgatagcagg atctacaggg ccctgggagt ccccacaagt ccctcctgac   2160

agacagaagg ggatgtttcc tcgtgggaca gaccaagtga gactggatga gcagctgact   2220

tccctggaag aaaatgtata cctggcagca ggcactgtgt atggactgga gacccagctg   2280

actgagctag aagatgccgc ccgctgcatc cacagtggca ctgatgagac ccatctggcg   2340

gatctggagg accaggtggc cacggctgca gcccaagtcc accatgctga actccagatt   2400

tcagatattg agagccggat ttcagccctg accattgcag gattaaacat agcaccatgt   2460

gtgcgcttca caagaagacg ggatcagaag caaaggaccc aggtacaaac catagataca   2520

tcaaggcagc aaaggaggaa actgcctgct ccaccggtga aagctgaaaa aattgagaca   2580

tcttcagtga ctaccattaa aacatttaac cacaacttca ttctccaagg ctcctcaaca   2640

aacaggacta aggaaaggaa aggcaccacc aaggatttga tggagcctgc tctggagtca   2700

gctgtgatgt actgacacca tggaattcca ctgccagtga cccactgcct ccggccgtac   2760

acgacagtgc cttgacccaa cagccatcga gtactgtatg tatttccacc tgaggagaag   2820

gcctggggag gccacagtgc accattgcac agggctgtcc tgatacctca tccagaaagc   2880

cgtctcagac ttcagcactg cggtcttgcc cactctctgc cttaggctcc caggggaatc   2940

caagacagaa aatgaagaca ctggcttcca acagcagcgc tccatgttta agatacatat   3000

tttccctgtt tgctttgcta ctgtatgttg actttaagat ctttttttaa atacatttga   3060

ttcagctagt attccatgtc aacaatttgt ccaaaggaaa actgctggag ggaggtggag   3120

ggaggaaggt gggaattatt atttaataca tcattaatgc ttattaatct ctcacaagca   3180

tctttgtctt gcaaatccta agggaaaagc aagtccctgc agtgagcact agggacagtc   3240

taatttgggg attgctcaac catcaagact gcaggtctcc cttcagccac ctccttcctg   3300

ctaaaagctt agcctaccac actaccagtc attcccatcg ctttgcaatc acaagccaca   3360

ggatgagaag ttctgactca ctcatgccat gcccagggct atctgaaaca atgtctcatt   3420

aagaatttag ggttcttcca tgggcttact gacagttgcc cagatctgaa ggggaaaggg   3480

tcttgagaaa gaccatcact ggctcaactt tagggcactg tccagagtca acatgatgtg   3540

gtttagcagt gatcacatct aaacaaagtt taggtaaatg aattatcgca gagaaaaacc   3600

acatgagaaa atttttgtac tccaaattta cttcccaata aatattcagc aaagtagtaa   3660

aatgacctta aagataaaaa tgattaggga atagccttag aaaatttata ggtataaaaa   3720

attcaaggac aaactgtgca tttaatggac acaagaattg actctaactc catgtctgtg   3780

gtttctttga acccatatca aatgtatgac tatttagagt gtttataaga gataatggaa   3840

ctgaactttc actcaattaa ttgggcatta acaaccttct tttatgtttg ttcctgatat   3900

agtctgaatc ttaggaagaa ggtaaaagaa aggaggcaag agaatagtta tgatgaatat   3960

gtgttaagtg cctgctctga aggaggcaat gttcttctca tttgaatcct tatggcaacc   4020

ttattcaata ggttttccca tatttcagat ttaataactg aaggccagag agattaattt   4080

gccaaagcca cacctttatg ctaattatga ttggaatgca tcacaaaagc ctaactctgt   4140

tgttttcaac ctctacgtta ttttgctgct atgtgcattt ccagatctga ttttctgcta   4200

acttgtgtgc tatgatccac tcctgatggg ggtctacatt aatcttccag tactccttgc   4260

tgatgctgtg ttatgtgtca tctaacagaa atgactcctt tgaaataagt aaatctttgg   4320

ctttttgttc tgttggtgtg attcaaagca aaacaaacaa acaaaaacaa attttaagaa   4380

cacaacaaaa aagatttgac ttccgaatag aatgttttct ttaagaggca tgaaaagcaa   4440

ctattgttgt gttacagtgt taaaaatatt cagttttctt tgacaaaaat gtgtactgtg   4500

taagccttgc aaacaaaaaa caacaaaaaa gaagcagcag cagcagcctg ctgtgtggca   4560

tctgaacttt tataaaggtt tccttgtgcc aaataagtgc aaagatttaa tttactatta   4620

aaaaccataa gcatatgtta tagttccaga agaattattt tgtcatcaag tgattttgat   4680

ctttagtgtc aatatttata tttagattaa tttttataaa tgaaaatatt ttaatggttt   4740

aagaaaatga ggacaacagg ataatatctt tgatgacttc tgaaagttat gcttcccttc   4800

atgttatatg cacattgcca agaattactg tcaagagaaa tgataagtaa aagtcattta   4860

tgaaaataaa aaaaaaaaaa aaaa                                          4884


<210>  322
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Gly Arg Lys Leu Asp Leu Ser Gly Leu Thr Asp Asp Glu Thr Glu 
1               5                   10                  15      


His Val Leu Gln Val Val Gln Arg Asp Phe Asn Leu Arg Lys Lys Glu 
            20                  25                  30          


Glu Glu Arg Leu Ser Glu Leu Lys Gln Lys Leu Asp Glu Glu Gly Ser 
        35                  40                  45              


Lys Cys Ser Ile Leu Ser Lys His Gln Gln Phe Val Glu His Cys Cys 
    50                  55                  60                  


Met Arg Cys Cys Ser Pro Phe Thr Phe Leu Val Asn Thr Lys Arg Gln 
65                  70                  75                  80  


Cys Gly Asp Cys Lys Phe Asn Val Cys Lys Ser Cys Cys Ser Tyr Gln 
                85                  90                  95      


Lys His Glu Lys Ala Trp Val Cys Cys Val Cys Gln Gln Ala Arg Leu 
            100                 105                 110         


Leu Arg Ala Gln Ser Leu Glu Trp Phe Tyr Asn Asn Val Lys Ser Arg 
        115                 120                 125             


Phe Lys Arg Phe Gly Ser Ala Lys Val Leu Lys Asn Leu Tyr Arg Lys 
    130                 135                 140                 


His Arg Leu Glu Ser Gly Ala Cys Phe Asp Ile Leu Gly Gly Ser Leu 
145                 150                 155                 160 


Phe Glu Ser Asn Leu Glu Asn Glu Gly Ser Ile Ser Gly Ser Asp Ser 
                165                 170                 175     


Thr Phe Tyr Arg Gln Ser Glu Gly His Ser Val Met Asp Thr Leu Ala 
            180                 185                 190         


Val Ala Leu Arg Val Ala Glu Glu Ala Ile Glu Glu Ala Ile Ser Lys 
        195                 200                 205             


Ala Glu Ala Tyr Gly Asp Ser Leu Asp Lys Gln Asn Glu Ala Ser Tyr 
    210                 215                 220                 


Leu Arg Asp His Lys Glu Glu Leu Thr Glu Glu Leu Ala Thr Thr Ile 
225                 230                 235                 240 


Leu Gln Lys Ile Ile Arg Lys Gln Lys Ser Lys Ser Glu Gln Gln Val 
                245                 250                 255     


Glu Glu Glu Pro Gly Trp Pro His Pro Gln Ser Cys Ser Thr Lys Val 
            260                 265                 270         


Ala Asp Glu Gly Thr Ser Ala Ser Pro Gly Gly Tyr Arg Ala Pro Ala 
        275                 280                 285             


Ala Leu Trp Arg Ser Gln Ser Ala Phe Ser Ile Thr Gly Glu Glu Ala 
    290                 295                 300                 


Leu Lys Thr Pro Pro Val Glu Ala Pro Ser Arg Gln Pro Arg Asp Gln 
305                 310                 315                 320 


Gly Gln His Pro Arg Ala Glu Ser Ala Leu Pro Ser Trp Lys Ser Val 
                325                 330                 335     


Asp Arg Leu Asp Glu Thr Asn Leu Ala Pro Val Leu Gln Ser Pro Asp 
            340                 345                 350         


Gly Asn Trp Val Ala Leu Lys Asp Gly Ala Pro Pro Pro Thr Arg Leu 
        355                 360                 365             


Leu Ala Lys Pro Lys Ser Gly Thr Phe Gln Ala Leu Glu Val Ala Ser 
    370                 375                 380                 


Ser Val Ala Ser Ala Tyr Asp Glu Met Gly Ser Asp Ser Glu Glu Asp 
385                 390                 395                 400 


Phe Asp Trp Ser Glu Ala Leu Ser Lys Leu Cys Pro Arg Ser Arg Ala 
                405                 410                 415     


Leu Pro Arg Asn Pro Gln Pro Gln Pro Thr Gln Ala Gln Ser Ser Asp 
            420                 425                 430         


Gln Gly Pro Ile Ala Ala Ser Pro Ser Ser Ala Leu Ser Pro Asn Pro 
        435                 440                 445             


Glu Ala Met Cys Ser Asp Ser Glu Thr Ser Ser Ala Gly Ser Ser Arg 
    450                 455                 460                 


Glu Val Gly His Gln Ala Arg Leu Ser Trp Leu Gln Arg Lys Ala Pro 
465                 470                 475                 480 


Arg Asn Pro Ala Ala Glu Lys Met Arg Leu His Gly Glu Leu Asp Val 
                485                 490                 495     


Asn Phe Asn Pro Gln Leu Ala Ser Arg Glu Thr Ser Asp Ser Ser Glu 
            500                 505                 510         


Pro Glu Glu Ala Pro His Thr Thr Asp Arg Arg Ala Arg Arg Trp Arg 
        515                 520                 525             


Arg Ala Arg Leu Gly Ser Glu Glu Pro Ser Lys Glu Pro Ser Ser Pro 
    530                 535                 540                 


Ser Ala Gln Leu Arg Asp Leu Asp Thr His Gln Val Ser Asp Asp Leu 
545                 550                 555                 560 


Ser Glu Thr Asp Ile Ser Asn Glu Ala Arg Asp Pro Gln Thr Leu Thr 
                565                 570                 575     


Asp Thr Thr Glu Glu Lys Arg Arg Asn Arg Leu Tyr Glu Leu Ala Met 
            580                 585                 590         


Lys Met Ser Glu Lys Glu Thr Ser Ser Gly Glu Asp Gln Glu Ser Glu 
        595                 600                 605             


Pro Lys Thr Glu Ser Glu Asn Gln Lys Glu Ser Leu Ser Ser Glu Asp 
    610                 615                 620                 


Asn Ser Gln Ser Val Gln Glu Glu Leu Lys Lys Lys Phe Ser Ala Val 
625                 630                 635                 640 


Ser Leu Cys Asn Ile Ser Thr Glu Val Leu Lys Val Ile Asn Ala Thr 
                645                 650                 655     


Glu Glu Leu Ile Ala Gly Ser Thr Gly Pro Trp Glu Ser Pro Gln Val 
            660                 665                 670         


Pro Pro Asp Arg Gln Lys Gly Met Phe Pro Arg Gly Thr Asp Gln Val 
        675                 680                 685             


Arg Leu Asp Glu Gln Leu Thr Ser Leu Glu Glu Asn Val Tyr Leu Ala 
    690                 695                 700                 


Ala Gly Thr Val Tyr Gly Leu Glu Thr Gln Leu Thr Glu Leu Glu Asp 
705                 710                 715                 720 


Ala Ala Arg Cys Ile His Ser Gly Thr Asp Glu Thr His Leu Ala Asp 
                725                 730                 735     


Leu Glu Asp Gln Val Ala Thr Ala Ala Ala Gln Val His His Ala Glu 
            740                 745                 750         


Leu Gln Ile Ser Asp Ile Glu Ser Arg Ile Ser Ala Leu Thr Ile Ala 
        755                 760                 765             


Gly Leu Asn Ile Ala Pro Cys Val Arg Phe Thr Arg Arg Arg Asp Gln 
    770                 775                 780                 


Lys Gln Arg Thr Gln Val Gln Thr Ile Asp Thr Ser Arg Gln Gln Arg 
785                 790                 795                 800 


Arg Lys Leu Pro Ala Pro Pro Val Lys Ala Glu Lys Ile Glu Thr Ser 
                805                 810                 815     


Ser Val Thr Thr Ile Lys Thr Phe Asn His Asn Phe Ile Leu Gln Gly 
            820                 825                 830         


Ser Ser Thr Asn Arg Thr Lys Glu Arg Lys Gly Thr Thr Lys Asp Leu 
        835                 840                 845             


Met Glu Pro Ala Leu Glu Ser Ala Val Met Tyr 
    850                 855                 


<210>  323
<211>  2254
<212>  DNA
<213>  Homo sapiens

<400>  323
gatccctccc atctcacagt acctcacagg tctcttcccc cgagcagtgc attgctggag     60

cgaggagaag ctcacgaatc agctgcaggt ctctgttttg aaaaagcaga gatacagagg    120

cagaggaaag gggtggactc ctatgtgacc tgttcttaga gcaagacaat caccatctga    180

attccagaag ccctgttcat ggttggggat attttctcga ctgcatggaa tcagaaagaa    240

gcaaaaggat gggaaatgcc tgcattcccc tgaaaagaat tgcttatttc ctatgtctct    300

tatctgcgct tttgctgact gaggggaaga aaccagcgaa gccaaaatgc cctgccgtgt    360

gtacttgtac caaagataat gctttatgtg agaatgccag atccattcca cgcaccgttc    420

ctcctgatgt tatctcatta tcctttgtga gatctggttt tactgaaatc tcagaaggga    480

gttttttatt cacgccatcg ctgcagctct tgttattcac atcgaactcc tttgatgtga    540

tcagtgatga tgcttttatt ggtcttccac atctagagta tttattcata gaaaacaaca    600

acatcaagtc aatttcaaga catactttcc ggggactaaa gtcattaatt cacttgagcc    660

ttgcaaacaa caatctccag acactcccaa aagatatttt caaaggcctg gattctttaa    720

caaatgtgga cctgaggggt aattcattta attgtgactg taaactgaaa tggctagtgg    780

aatggcttgg ccacaccaat gcaactgttg aagacatcta ctgcgaaggc cccccagaat    840

acaagaagcg caaaatcaat agtctctcct cgaaggattt cgattgcatc attacagaat    900

ttgcaaagtc tcaagacctg ccttatcaat cattgtccat agacactttt tcttatttga    960

atgatgagta tgtagtcatc gctcagcctt ttactggaaa atgcattttc cttgaatggg   1020

accatgtgga aaagaccttc cggaattatg acaacattac aggcacatcc actgtagtat   1080

gcaagcctat agtcattgaa actcagctct atgttattgt ggcccagctg tttggtggct   1140

ctcacatcta taagcgagac agttttgcaa ataaattcat aaaaatccag gatattgaaa   1200

ttctcaaaat ccgaaaaccc aatgacattg aaacattcaa gattgaaaac aactggtact   1260

ttgttgttgc tgacagttca aaagctggtt ttactaccat ttacaaatgg aacggaaacg   1320

gattctactc ccatcaatcc ttacacgcgt ggtacaggga cactgatgtg gaatatctag   1380

aaatagtcag aacacctcag acactcagaa cgcctcattt aattctgtct agtagttccc   1440

agcgtcctgt aatttatcag tggaacaaag caacacaatt attcactaac caaactgaca   1500

ttcctaacat ggaggatgtg tacgcagtga agcacttctc agtgaaaggg gacgtgtaca   1560

tttgcttgac aagattcatt ggtgattcca aagtcatgaa atggggaggc tcctcgttcc   1620

aggatattca gaggatgcca tcgcgaggat ccatggtgtt ccagcctctt caaataaata   1680

attaccaata tgcaattctt ggaagtgatt actcctttac tcaagtgtat aactgggatg   1740

cagagaaagc caaatttgtg aaatttcagg aattaaatgt tcaggcacca agatcattca   1800

cacatgtgtc cattaataag cgtaattttc tttttgcttc cagttttaag ggaaatacac   1860

agatttacaa acatgtcata gttgacttaa gcgcatgaga caccaaattc tgtggctgcc   1920

atcagaaatt ttctacagta catgacccgg atgaactcaa tgcatgatga ctcttcttat   1980

cacacttgca aatgaatgcc tttcaaacat tgagactgct agaaccaagc actaccagta   2040

tctccatcct taactgtcca gtccagtgat gtgggaagtt accttttata agacaaaatt   2100

taattgtgta actgttcttt gcagtgaaga tgtgtaaata agcgtttaat ggtatctgtt   2160

actccaaaaa gaaatattaa tatgtacttt tccatttatt tattcatgtg tacagaaaca   2220

actgccaaat aaaatgttta cattttcttt cata                               2254


<210>  324
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


Leu Phe Thr Ser Asn Ser Phe Asp Val Ile Ser Asp Asp Ala Phe Ile 
            100                 105                 110         


Gly Leu Pro His Leu Glu Tyr Leu Phe Ile Glu Asn Asn Asn Ile Lys 
        115                 120                 125             


Ser Ile Ser Arg His Thr Phe Arg Gly Leu Lys Ser Leu Ile His Leu 
    130                 135                 140                 


Ser Leu Ala Asn Asn Asn Leu Gln Thr Leu Pro Lys Asp Ile Phe Lys 
145                 150                 155                 160 


Gly Leu Asp Ser Leu Thr Asn Val Asp Leu Arg Gly Asn Ser Phe Asn 
                165                 170                 175     


Cys Asp Cys Lys Leu Lys Trp Leu Val Glu Trp Leu Gly His Thr Asn 
            180                 185                 190         


Ala Thr Val Glu Asp Ile Tyr Cys Glu Gly Pro Pro Glu Tyr Lys Lys 
        195                 200                 205             


Arg Lys Ile Asn Ser Leu Ser Ser Lys Asp Phe Asp Cys Ile Ile Thr 
    210                 215                 220                 


Glu Phe Ala Lys Ser Gln Asp Leu Pro Tyr Gln Ser Leu Ser Ile Asp 
225                 230                 235                 240 


Thr Phe Ser Tyr Leu Asn Asp Glu Tyr Val Val Ile Ala Gln Pro Phe 
                245                 250                 255     


Thr Gly Lys Cys Ile Phe Leu Glu Trp Asp His Val Glu Lys Thr Phe 
            260                 265                 270         


Arg Asn Tyr Asp Asn Ile Thr Gly Thr Ser Thr Val Val Cys Lys Pro 
        275                 280                 285             


Ile Val Ile Glu Thr Gln Leu Tyr Val Ile Val Ala Gln Leu Phe Gly 
    290                 295                 300                 


Gly Ser His Ile Tyr Lys Arg Asp Ser Phe Ala Asn Lys Phe Ile Lys 
305                 310                 315                 320 


Ile Gln Asp Ile Glu Ile Leu Lys Ile Arg Lys Pro Asn Asp Ile Glu 
                325                 330                 335     


Thr Phe Lys Ile Glu Asn Asn Trp Tyr Phe Val Val Ala Asp Ser Ser 
            340                 345                 350         


Lys Ala Gly Phe Thr Thr Ile Tyr Lys Trp Asn Gly Asn Gly Phe Tyr 
        355                 360                 365             


Ser His Gln Ser Leu His Ala Trp Tyr Arg Asp Thr Asp Val Glu Tyr 
    370                 375                 380                 


Leu Glu Ile Val Arg Thr Pro Gln Thr Leu Arg Thr Pro His Leu Ile 
385                 390                 395                 400 


Leu Ser Ser Ser Ser Gln Arg Pro Val Ile Tyr Gln Trp Asn Lys Ala 
                405                 410                 415     


Thr Gln Leu Phe Thr Asn Gln Thr Asp Ile Pro Asn Met Glu Asp Val 
            420                 425                 430         


Tyr Ala Val Lys His Phe Ser Val Lys Gly Asp Val Tyr Ile Cys Leu 
        435                 440                 445             


Thr Arg Phe Ile Gly Asp Ser Lys Val Met Lys Trp Gly Gly Ser Ser 
    450                 455                 460                 


Phe Gln Asp Ile Gln Arg Met Pro Ser Arg Gly Ser Met Val Phe Gln 
465                 470                 475                 480 


Pro Leu Gln Ile Asn Asn Tyr Gln Tyr Ala Ile Leu Gly Ser Asp Tyr 
                485                 490                 495     


Ser Phe Thr Gln Val Tyr Asn Trp Asp Ala Glu Lys Ala Lys Phe Val 
            500                 505                 510         


Lys Phe Gln Glu Leu Asn Val Gln Ala Pro Arg Ser Phe Thr His Val 
        515                 520                 525             


Ser Ile Asn Lys Arg Asn Phe Leu Phe Ala Ser Ser Phe Lys Gly Asn 
    530                 535                 540                 


Thr Gln Ile Tyr Lys His Val Ile Val Asp Leu Ser Ala 
545                 550                 555         


<210>  325
<211>  4784
<212>  DNA
<213>  Homo sapiens

<400>  325
gaggcgacac tgagtctcca agtccggaga ggtgcccgag ggaaaagagg cggcagctaa     60

actggtcctg gagagaagcc ccttccgccc ctctcctcag ccagcatgtc ccggactccg    120

ccgctcctca gtccgcgcgg tggggacccc gggccgtggc ggccggcgca gccctgacgg    180

gttgcgaacc agggggcgcc ccgaacgcgg gggttggggt ctgggagcgc gagcggccgc    240

tacggtacga gcggggtgtg ctgagtcccg tggccacccc cggccccagc catgaggagg    300

gacgagcgag acgccaaagc catgcggtcc ctgcagccgc cggatggggc cggctcgccc    360

cccgagagtc tgaggaacgg ctacgtgaag agctgcgtga gccccttgcg gcaggaccct    420

ccgcgcggct tcttcttcca cctctgccgc ttctgcaacg tggagctgcg gccgccgccg    480

gcctctcccc agcagccgcg gcgctgctcc cccttctgcc gggcgcgcct ctcgctgggc    540

gccctggctg cctttgtcct cgccctgctg ctgggcgcgg aacccgagag ctgggctgcc    600

ggggccgcct ggctgcggac gctgctgagc gtgtgttcgc acagcttgag ccccctcttc    660

agcatcgcct gtgccttctt cttcctcacc tgcttcctca cccggaccaa gcggggaccc    720

ggcccgggcc ggagctgcgg ctcctggtgg ctgctggcgc tgcccgcctg ctgttacctg    780

ggggacttct tggtgtggca gtggtggtct tggccttggg gggatggcga cgcagggtcc    840

gcggccccgc acacgccccc ggaggcggca gcgggcaggt tgctgctggt gctgagctgc    900

gtagggctgc tgctgacgct cgcgcacccg ctgcggctcc ggcactgcgt tctggtgctg    960

ctcctggcca gcttcgtctg gtgggtctcc ttcaccagcc tcgggtcgct gccctccgcc   1020

ctcaggccgc tgctctccgg cctggtgggg ggcgctggct gcctgctggc cctggggttg   1080

gatcacttct ttcaaatcag ggaagcgcct cttcatcctc gactgtccag tgccgccgaa   1140

gaaaaagtgc ctgtgatccg accccggagg aggtccagct gcgtgtcgtt aggagaaact   1200

gcagccagtt actatggcag ttgcaaaata ttcaggagac cgtcgttgcc ttgtatttcc   1260

agagaacaga tgattctttg ggattgggac ttaaaacaat ggtataagcc tcattatcaa   1320

aattctggag gtggaaatgg agttgatctt tcagtgctaa atgaggctcg caatatggtg   1380

tcagatcttc tgactgatcc aagccttcca ccacaagtca tttcctctct acggagtatt   1440

agtagcttaa tgggtgcttt ctcaggttcc tgtaggccaa agattaatcc tctcacacca   1500

tttcctggat tttacccctg ttctgaaata gaggacccag ctgagaaagg ggatagaaaa   1560

cttaacaagg gactaaatag gaatagtttg ccaactccac agctgaggag aagctcagga   1620

acttcaggat tgctacctgt tgaacagtct tcaaggtggg atcgtaataa tggcaaaagg   1680

cctcaccaag aatttggcat ttcaagtcaa ggatgctatc taaatgggcc ttttaattca   1740

aatctactga ctatcccgaa gcaaaggtca tcttctgtat cactgactca ccatgtaggt   1800

ctcagaagag ctggtgtttt gtccagtctg agtcctgtga attcttccaa ccatggacca   1860

gtgtctactg gctctctaac taatcgatca cccatagaat ttcctgatac tgctgatttt   1920

cttaataagc caagcgttat cttgcagaga tctctgggca atgcacctaa tactccagat   1980

ttttatcagc aacttagaaa ttctgatagc aatctgtgta acagctgtgg acatcaaatg   2040

ctgaaatatg tttcaacatc tgaatcagat ggtacagatt gctgcagtgg aaaatcaggt   2100

gaagaagaaa acattttctc gaaagaatca ttcaaactta tggaaactca acaagaagag   2160

gaaacagaga agaaagacag cagaaaatta tttcaggaag gtgataagtg gctaacagaa   2220

gaggcacaga gtgaacagca aacaaatatt gaacaggaag tatcactgga cctgatttta   2280

gtagaagagt atgactcatt aatagaaaag atgagcaact ggaattttcc aatttttgaa   2340

cttgtagaaa agatgggaga gaaatcagga aggattctca gtcaggttat gtatacctta   2400

tttcaagaca ctggtttatt ggaaatattt aaaattccca ctcaacaatt tatgaactat   2460

tttcgtgcat tagaaaatgg ctatcgagac attccttatc acaatcgtat acatgccaca   2520

gatgtgctac atgcagtttg gtatctgaca acacggccag ttcctggctt acagcagatc   2580

cacaatggtt gtggaacagg aaatgaaaca gattctgatg gtagaattaa ccatgggcga   2640

attgcttata tttcttcgaa gagctgctct aatcctgatg agagttatgg ctgcctgtct   2700

tcaaacattc ctgcattaga attgatggct ctatacgtgg cagctgccat gcatgattat   2760

gatcacccag ggaggacaaa tgcatttcta gtggctacaa atgcccctca ggcagtttta   2820

tacaatgaca gatctgttct ggaaaatcat catgctgcgt cagcttggaa tctatatctt   2880

tctcgcccag aatacaactt ccttcttcat cttgatcatg tggaattcaa gcgctttcgt   2940

tttttagtca ttgaagcaat ccttgctacg gatcttaaaa agcattttga ttttctcgca   3000

gaattcaatg ccaaggcaaa tgatgtaaat agtaatggca tagaatggag taatgaaaat   3060

gatcgcctct tggtatgcca ggtgtgcatc aaactggcag atataaatgg cccagcaaaa   3120

gttcgagact tgcatttgaa atggacagaa ggcattgtca atgaatttta tgagcaggga   3180

gatgaagaag caaatcttgg tctgcccatc agtccattca tggatcgttc ttctcctcaa   3240

ctagcaaaac tccaagaatc ttttatcacc cacatagtgg gtcccctgtg taactcctat   3300

gatgctgctg gtttgctacc aggtcagtgg ttagaagcag aagaggataa tgatactgaa   3360

agtggtgatg atgaagacgg tgaagaatta gatacagaag atgaagaaat ggaaaacaat   3420

ctaaatccaa aaccaccaag aaggaaaagc agacggcgaa tattttgtca gctaatgcac   3480

cacctcactg aaaaccacaa gatatggaag gaaatcgtag aggaagaaga aaaatgtaaa   3540

gctgatggga ataaactgca ggtggagaat tcctccttac ctcaagcaga tgagattcag   3600

gtaattgaag aggcagatga agaggaatag cgacagtttg agtaaaagaa aagtcatatt   3660

gaagaagccc agagggttgt gcccaggggc agaaatcatt gcctagtgtt caccggctga   3720

ctctcaactg accattccca tgtggacagg ccttaatact gtgagaggat ccttgctctg   3780

ctggcagttt cccactccta tgcactttca caggaactag aaaactattc ttaaaccaaa   3840

aataccatcc gtgttgaccc atgttgcaga gcccttactt aaatccttca ctggtgtatg   3900

aatactttgt cataatgctg ctttgctggg tagtgagctc ttatttttca ctgggggtca   3960

gctataacta aaaactcaag tgacatattt cagttaccaa agtggccagg aactttttgc   4020

ttttatgaaa atagattcat attgtatttc ccagtgtgtc ttttatgtct ttgaatgttt   4080

tggagaaaag tctatgcctg tctaaaaatg aatccagtgt tgcctttctg agggatttct   4140

gctcaatgca atacactgtt cagtgctatt ctcccagcta ggtttatcca tgaaggactg   4200

agtgaccttt gttgtattta acaaaatcca ggtgcatcaa tttctgatgc tttttactat   4260

tgtgtattat ctactatgtg tgttttattt ctgctgagag tattcaggtt tgccatggac   4320

atcagaagtt tgaattccag tcttatctta tgttccatgg ctgaatttta aagctgttta   4380

ggtttaacaa tgaagggatt tattctttag tcaaaattgt tgtttttact ctagctcagg   4440

attcgtattt ttaaagattt agttaatata aacacagcac agatttgtca gaagaaaaaa   4500

aatttgctgt aataccaaaa ctaacctcat caaagataca gaaaaaaaga aatatagtga   4560

gccctaaagg acacatacat tgaataaata attggaacat gtggttatct ttagatccac   4620

atcttagctg tcatttgttc actctaaaac tgatgttcat ctttctgtta atttccctct   4680

gcctaaagag tacatgacag aaatgaccta tcactactta ttatttctga agcctaactg   4740

caagagtgat ttcttgagaa caagtaaaga actggctcgt gccg                    4784


<210>  326
<211>  1112
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Arg Arg Asp Glu Arg Asp Ala Lys Ala Met Arg Ser Leu Gln Pro 
1               5                   10                  15      


Pro Asp Gly Ala Gly Ser Pro Pro Glu Ser Leu Arg Asn Gly Tyr Val 
            20                  25                  30          


Lys Ser Cys Val Ser Pro Leu Arg Gln Asp Pro Pro Arg Gly Phe Phe 
        35                  40                  45              


Phe His Leu Cys Arg Phe Cys Asn Val Glu Leu Arg Pro Pro Pro Ala 
    50                  55                  60                  


Ser Pro Gln Gln Pro Arg Arg Cys Ser Pro Phe Cys Arg Ala Arg Leu 
65                  70                  75                  80  


Ser Leu Gly Ala Leu Ala Ala Phe Val Leu Ala Leu Leu Leu Gly Ala 
                85                  90                  95      


Glu Pro Glu Ser Trp Ala Ala Gly Ala Ala Trp Leu Arg Thr Leu Leu 
            100                 105                 110         


Ser Val Cys Ser His Ser Leu Ser Pro Leu Phe Ser Ile Ala Cys Ala 
        115                 120                 125             


Phe Phe Phe Leu Thr Cys Phe Leu Thr Arg Thr Lys Arg Gly Pro Gly 
    130                 135                 140                 


Pro Gly Arg Ser Cys Gly Ser Trp Trp Leu Leu Ala Leu Pro Ala Cys 
145                 150                 155                 160 


Cys Tyr Leu Gly Asp Phe Leu Val Trp Gln Trp Trp Ser Trp Pro Trp 
                165                 170                 175     


Gly Asp Gly Asp Ala Gly Ser Ala Ala Pro His Thr Pro Pro Glu Ala 
            180                 185                 190         


Ala Ala Gly Arg Leu Leu Leu Val Leu Ser Cys Val Gly Leu Leu Leu 
        195                 200                 205             


Thr Leu Ala His Pro Leu Arg Leu Arg His Cys Val Leu Val Leu Leu 
    210                 215                 220                 


Leu Ala Ser Phe Val Trp Trp Val Ser Phe Thr Ser Leu Gly Ser Leu 
225                 230                 235                 240 


Pro Ser Ala Leu Arg Pro Leu Leu Ser Gly Leu Val Gly Gly Ala Gly 
                245                 250                 255     


Cys Leu Leu Ala Leu Gly Leu Asp His Phe Phe Gln Ile Arg Glu Ala 
            260                 265                 270         


Pro Leu His Pro Arg Leu Ser Ser Ala Ala Glu Glu Lys Val Pro Val 
        275                 280                 285             


Ile Arg Pro Arg Arg Arg Ser Ser Cys Val Ser Leu Gly Glu Thr Ala 
    290                 295                 300                 


Ala Ser Tyr Tyr Gly Ser Cys Lys Ile Phe Arg Arg Pro Ser Leu Pro 
305                 310                 315                 320 


Cys Ile Ser Arg Glu Gln Met Ile Leu Trp Asp Trp Asp Leu Lys Gln 
                325                 330                 335     


Trp Tyr Lys Pro His Tyr Gln Asn Ser Gly Gly Gly Asn Gly Val Asp 
            340                 345                 350         


Leu Ser Val Leu Asn Glu Ala Arg Asn Met Val Ser Asp Leu Leu Thr 
        355                 360                 365             


Asp Pro Ser Leu Pro Pro Gln Val Ile Ser Ser Leu Arg Ser Ile Ser 
    370                 375                 380                 


Ser Leu Met Gly Ala Phe Ser Gly Ser Cys Arg Pro Lys Ile Asn Pro 
385                 390                 395                 400 


Leu Thr Pro Phe Pro Gly Phe Tyr Pro Cys Ser Glu Ile Glu Asp Pro 
                405                 410                 415     


Ala Glu Lys Gly Asp Arg Lys Leu Asn Lys Gly Leu Asn Arg Asn Ser 
            420                 425                 430         


Leu Pro Thr Pro Gln Leu Arg Arg Ser Ser Gly Thr Ser Gly Leu Leu 
        435                 440                 445             


Pro Val Glu Gln Ser Ser Arg Trp Asp Arg Asn Asn Gly Lys Arg Pro 
    450                 455                 460                 


His Gln Glu Phe Gly Ile Ser Ser Gln Gly Cys Tyr Leu Asn Gly Pro 
465                 470                 475                 480 


Phe Asn Ser Asn Leu Leu Thr Ile Pro Lys Gln Arg Ser Ser Ser Val 
                485                 490                 495     


Ser Leu Thr His His Val Gly Leu Arg Arg Ala Gly Val Leu Ser Ser 
            500                 505                 510         


Leu Ser Pro Val Asn Ser Ser Asn His Gly Pro Val Ser Thr Gly Ser 
        515                 520                 525             


Leu Thr Asn Arg Ser Pro Ile Glu Phe Pro Asp Thr Ala Asp Phe Leu 
    530                 535                 540                 


Asn Lys Pro Ser Val Ile Leu Gln Arg Ser Leu Gly Asn Ala Pro Asn 
545                 550                 555                 560 


Thr Pro Asp Phe Tyr Gln Gln Leu Arg Asn Ser Asp Ser Asn Leu Cys 
                565                 570                 575     


Asn Ser Cys Gly His Gln Met Leu Lys Tyr Val Ser Thr Ser Glu Ser 
            580                 585                 590         


Asp Gly Thr Asp Cys Cys Ser Gly Lys Ser Gly Glu Glu Glu Asn Ile 
        595                 600                 605             


Phe Ser Lys Glu Ser Phe Lys Leu Met Glu Thr Gln Gln Glu Glu Glu 
    610                 615                 620                 


Thr Glu Lys Lys Asp Ser Arg Lys Leu Phe Gln Glu Gly Asp Lys Trp 
625                 630                 635                 640 


Leu Thr Glu Glu Ala Gln Ser Glu Gln Gln Thr Asn Ile Glu Gln Glu 
                645                 650                 655     


Val Ser Leu Asp Leu Ile Leu Val Glu Glu Tyr Asp Ser Leu Ile Glu 
            660                 665                 670         


Lys Met Ser Asn Trp Asn Phe Pro Ile Phe Glu Leu Val Glu Lys Met 
        675                 680                 685             


Gly Glu Lys Ser Gly Arg Ile Leu Ser Gln Val Met Tyr Thr Leu Phe 
    690                 695                 700                 


Gln Asp Thr Gly Leu Leu Glu Ile Phe Lys Ile Pro Thr Gln Gln Phe 
705                 710                 715                 720 


Met Asn Tyr Phe Arg Ala Leu Glu Asn Gly Tyr Arg Asp Ile Pro Tyr 
                725                 730                 735     


His Asn Arg Ile His Ala Thr Asp Val Leu His Ala Val Trp Tyr Leu 
            740                 745                 750         


Thr Thr Arg Pro Val Pro Gly Leu Gln Gln Ile His Asn Gly Cys Gly 
        755                 760                 765             


Thr Gly Asn Glu Thr Asp Ser Asp Gly Arg Ile Asn His Gly Arg Ile 
    770                 775                 780                 


Ala Tyr Ile Ser Ser Lys Ser Cys Ser Asn Pro Asp Glu Ser Tyr Gly 
785                 790                 795                 800 


Cys Leu Ser Ser Asn Ile Pro Ala Leu Glu Leu Met Ala Leu Tyr Val 
                805                 810                 815     


Ala Ala Ala Met His Asp Tyr Asp His Pro Gly Arg Thr Asn Ala Phe 
            820                 825                 830         


Leu Val Ala Thr Asn Ala Pro Gln Ala Val Leu Tyr Asn Asp Arg Ser 
        835                 840                 845             


Val Leu Glu Asn His His Ala Ala Ser Ala Trp Asn Leu Tyr Leu Ser 
    850                 855                 860                 


Arg Pro Glu Tyr Asn Phe Leu Leu His Leu Asp His Val Glu Phe Lys 
865                 870                 875                 880 


Arg Phe Arg Phe Leu Val Ile Glu Ala Ile Leu Ala Thr Asp Leu Lys 
                885                 890                 895     


Lys His Phe Asp Phe Leu Ala Glu Phe Asn Ala Lys Ala Asn Asp Val 
            900                 905                 910         


Asn Ser Asn Gly Ile Glu Trp Ser Asn Glu Asn Asp Arg Leu Leu Val 
        915                 920                 925             


Cys Gln Val Cys Ile Lys Leu Ala Asp Ile Asn Gly Pro Ala Lys Val 
    930                 935                 940                 


Arg Asp Leu His Leu Lys Trp Thr Glu Gly Ile Val Asn Glu Phe Tyr 
945                 950                 955                 960 


Glu Gln Gly Asp Glu Glu Ala Asn Leu Gly Leu Pro Ile Ser Pro Phe 
                965                 970                 975     


Met Asp Arg Ser Ser Pro Gln Leu Ala Lys Leu Gln Glu Ser Phe Ile 
            980                 985                 990         


Thr His Ile Val Gly Pro Leu Cys  Asn Ser Tyr Asp Ala  Ala Gly Leu 
        995                 1000                 1005             


Leu Pro  Gly Gln Trp Leu Glu  Ala Glu Glu Asp Asn  Asp Thr Glu 
    1010                 1015                 1020             


Ser Gly  Asp Asp Glu Asp Gly  Glu Glu Leu Asp Thr  Glu Asp Glu 
    1025                 1030                 1035             


Glu Met  Glu Asn Asn Leu Asn  Pro Lys Pro Pro Arg  Arg Lys Ser 
    1040                 1045                 1050             


Arg Arg  Arg Ile Phe Cys Gln  Leu Met His His Leu  Thr Glu Asn 
    1055                 1060                 1065             


His Lys  Ile Trp Lys Glu Ile  Val Glu Glu Glu Glu  Lys Cys Lys 
    1070                 1075                 1080             


Ala Asp  Gly Asn Lys Leu Gln  Val Glu Asn Ser Ser  Leu Pro Gln 
    1085                 1090                 1095             


Ala Asp  Glu Ile Gln Val Ile  Glu Glu Ala Asp Glu  Glu Glu 
    1100                 1105                 1110         


<210>  327
<211>  4038
<212>  DNA
<213>  Homo sapiens

<400>  327
gtgcgtgggg gtaaccggcg cgggcgccga gatagcgccg ggcagaggga cccggctacc     60

ctggacagcg catcgccgcc cgcccgggtc cgcgccacag ccgctgcgga tcatggaaca    120

tctaaaggcc tttgatgatg aaatcaatgc ttttttggac aatatgtttg gaccgcgaga    180

ttctcgagtc agagggtggt tcatgttgga ctcttacctt cctacctttt ttcttactgt    240

catgtatctg ctctcaatat ggctgggtaa caagtatatg aagaacagac ctgctctttc    300

tctcaggggt atcctcacct tgtataatct tggaatcaca cttctatccg cgtacatgct    360

ggcagagctc attctctcca cttgggaagg aggctacaac ttacagtgtc aagatcttac    420

cagcgcaggg gaagctgaca tccgggtagc caaggtgctt tggtggtact atttctccaa    480

atcagtagag ttcctggaca caattttctt cgttttgcgg aaaaaaacga gtcagattac    540

ttttcttcat gtatatcatc atgcttctat gtttaacatc tggtggtgtg tcttgaactg    600

gataccttgt ggacaaagtt tctttggacc aacactgaac agttttatcc acattcttat    660

gtactcctac tatggacttt ctgtgtttcc atctatgcac aagtatcttt ggtggaagaa    720

atatctcaca caggctcagc tggtgcagtt cgtgctcgcc atcacgcaca ccatgagcgc    780

cgtcgtgaaa ccgtgtggct tccccttcgg ttgtctcatc ttccagtcat cttatatgct    840

aacgttagtc atcctcttct taaattttta cgttcagaca taccgaaaaa agccaatgaa    900

gaaagatatg caagagccac ctgcagggaa agaagtgaag aatggttttt ccaaagccta    960

cttcactgca gcaaatggag tgatgaacaa gaaagcacaa taaaaatgag taacagaaaa   1020

agcacatata ctagcctaac agattcgctt gttttaaagc aaagactgaa ttgaaggtta   1080

catgttttag gataaactaa tttcttttga gttcataaat catttgtacc cagaatgtat   1140

taatatattg ctattaggtt aatctgttaa ctgaatgctt tgatcagcat tgaggtgatg   1200

ctcacctccg aggacctcag aactggtgca gcttctctct ccctccctcc cacagactga   1260

acctttcgcc agaagctgtc cttataacgc cttatacgca tacacagcca ggaaacgtgg   1320

agcattgttt ctcacagaga gtctccaaat aaaaagggtt ttgttcagat taaaatgttt   1380

acaacaaaat gttaattata ttctaaatac agggtatgtt ctaatctata ttaagcaata   1440

atgccggtgc ataatcattc catttgttcc tttagcaatc aaccccagaa aatattaaaa   1500

tgggatcata cacagaagat agaaaaatct agcaaaactt ctctttctgt aagccagagt   1560

cttgtctatc agattcccac aaccactcct gattctaaat ttagtgatat ggtaatgaaa   1620

ttggtattta ttttaaatat tagttattct aaggagaaaa aaatgcttct gcaagatttt   1680

cataattcgg gggctgtgga taggattgtt cctctgtttc cctaatcatt catctgttca   1740

tgtctccctc ttgtgccagt cagcctaggt tatacagatg ccatgctcca caccacgagc   1800

agtgtacaaa tctggctgcc cgtttacttt ctgagcaagc actggagtcc actccgacct   1860

ttttctttga acatgcatgc tgctggaata tgtataaatc agaactagca gaagtagcag   1920

agtgatggga gcaaaatagg cactgaattc gtcaactctt ttttgtgagc ctacttgtga   1980

atattacctc agatacctgt tgtcactctt cacaggttat ttaagttttt gaagctggga   2040

ggagaaagat ggagtagctt ggaaagattc cagcactgag ccgtgggccg gtcatgagcc   2100

acgataaaaa atgccagttt ggcaaactca gcactcctgt tccctgctca ggtatatgcg   2160

atctctactg agaagcaagc acaaaagtag acaaaagtat taatgagtat ttcctttctc   2220

cataagtgca ggactgttac tcactactaa actctaccaa gaatggaaac aaagaatatt   2280

ttctgaagat ttttttgaag attaatttat accctataaa ataaaacttg ttagcttcga   2340

tgaagtcact tcatcttctc tcctacctta tttttttaaa taagttttta ggtcctgaca   2400

ctgacatcaa atacatgcac accagaaagg catttccacc accgtcccca ctcattagcg   2460

tccagagtgc ctttctctct cggctttttt tcccccctga gctctagttt taaactttct   2520

cctgttaaaa aaattgtact tttatttcat gtaaactgcc cctctgagga tttgggcata   2580

ttttttggaa ggtgcctaat gcttaggata gtctctaggg tgatgcactg cacctgcttc   2640

cttcccttca gtgcggccga cccatttctg ttgaacagat gtctcctgtg tgatgcccct   2700

gactcttaca tttatctttc taaatcattt tctgaagctg acttgctcta gggtgcttca   2760

tcaccacttc catcttgcat caccttataa ctgttctgtc ttgttctctc ccagcaattt   2820

attttaaaac aagggctagc ttcaagcatg actgttaatg gctcctctgt gacaaaacac   2880

aagttggacc aaggagaaag ccctttggag aaactggacc ctagttcagt ttagatctca   2940

aatataggct gaaatctctt accaaagtgc gttccagata aaaatgagac ttagaagaca   3000

gactggtcta atatgctcac tggtcatcac attcagctta ttcttacgtg ccagtgaggc   3060

cctaaggtct cagtgcatag catacctgcc actctggatg ttttcctggg cttcatatct   3120

gtatggcaag gagggagctg tccttcagca gacaaagtca agcagcttta agtacaaggc   3180

agcttgaaac ctctctgatg aaagtgaaaa atgtgggtag cttatacttt caaactaatg   3240

ccagtgacta gagagaggtt tcattcatga tgtgtatttc caatttggtc ttcaattcaa   3300

gagatgcttc ataaaacact tatagcctta aaccattcaa gggctaatta aaaaaatagt   3360

tatgaaatct tagccacaaa aaataaatca ggtaaacatt ttaacctgtc gttaagtgtt   3420

gtaacttcaa aaaaccaaaa tgcttatttt aatgtgattt ttctaaaact attgaaaaat   3480

taatatttct ataatctatt aaaaaaaatg gagaatgttt tctctcaaat ttcctctgac   3540

ccatgggaat gaaaatactt aaatactgta aagcatatct attaataatt cccccaattt   3600

tttaaactaa caaaatggaa tgttaactga atggaattaa acatagcaat tgtcaagcca   3660

tcaaaattat atatcgaacc acttaggcat gttacggggt aaagtcctca cccctgcatt   3720

tgagaaatat tttattattt ttattttaag gcaaaacagt gtttactgtg atgggcagaa   3780

cagccttttg tatctaggag tccatttgag ttctttccaa tatttccata tcgttcataa   3840

atgtgtctgg gggcttcctt gtttggaaaa tatggatatc gctttgtttt cctttgaaag   3900

taattatatc ttaagaacat agtatcatga atggagtaga cagggaggct gcagaagcca   3960

tttttctttg tagataaaaa gcattatcta tgattgttgt ataataaatt gatttttaca   4020

ttaaaaaaaa aaaaaaaa                                                 4038


<210>  328
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Glu His Leu Lys Ala Phe Asp Asp Glu Ile Asn Ala Phe Leu Asp 
1               5                   10                  15      


Asn Met Phe Gly Pro Arg Asp Ser Arg Val Arg Gly Trp Phe Met Leu 
            20                  25                  30          


Asp Ser Tyr Leu Pro Thr Phe Phe Leu Thr Val Met Tyr Leu Leu Ser 
        35                  40                  45              


Ile Trp Leu Gly Asn Lys Tyr Met Lys Asn Arg Pro Ala Leu Ser Leu 
    50                  55                  60                  


Arg Gly Ile Leu Thr Leu Tyr Asn Leu Gly Ile Thr Leu Leu Ser Ala 
65                  70                  75                  80  


Tyr Met Leu Ala Glu Leu Ile Leu Ser Thr Trp Glu Gly Gly Tyr Asn 
                85                  90                  95      


Leu Gln Cys Gln Asp Leu Thr Ser Ala Gly Glu Ala Asp Ile Arg Val 
            100                 105                 110         


Ala Lys Val Leu Trp Trp Tyr Tyr Phe Ser Lys Ser Val Glu Phe Leu 
        115                 120                 125             


Asp Thr Ile Phe Phe Val Leu Arg Lys Lys Thr Ser Gln Ile Thr Phe 
    130                 135                 140                 


Leu His Val Tyr His His Ala Ser Met Phe Asn Ile Trp Trp Cys Val 
145                 150                 155                 160 


Leu Asn Trp Ile Pro Cys Gly Gln Ser Phe Phe Gly Pro Thr Leu Asn 
                165                 170                 175     


Ser Phe Ile His Ile Leu Met Tyr Ser Tyr Tyr Gly Leu Ser Val Phe 
            180                 185                 190         


Pro Ser Met His Lys Tyr Leu Trp Trp Lys Lys Tyr Leu Thr Gln Ala 
        195                 200                 205             


Gln Leu Val Gln Phe Val Leu Ala Ile Thr His Thr Met Ser Ala Val 
    210                 215                 220                 


Val Lys Pro Cys Gly Phe Pro Phe Gly Cys Leu Ile Phe Gln Ser Ser 
225                 230                 235                 240 


Tyr Met Leu Thr Leu Val Ile Leu Phe Leu Asn Phe Tyr Val Gln Thr 
                245                 250                 255     


Tyr Arg Lys Lys Pro Met Lys Lys Asp Met Gln Glu Pro Pro Ala Gly 
            260                 265                 270         


Lys Glu Val Lys Asn Gly Phe Ser Lys Ala Tyr Phe Thr Ala Ala Asn 
        275                 280                 285             


Gly Val Met Asn Lys Lys Ala Gln 
    290                 295     


<210>  329
<211>  5811
<212>  DNA
<213>  Homo sapiens

<400>  329
ctcctcccct ccccctccgc cctcctccgc tccgggccag cgcggcggcg gcggcggcgg     60

cggcagcagc aggagcagcc ccggctgcgg gtcgcgacgg cggcggggcg ccccctcccc    120

cgtgccgggg cgcggcggag ggatgtgggg ccttgcggga ggaaggcttt tcggcatctt    180

ctcggccccg gtgctggtgg ctgtggtgtg ctgcgcccag agtgtgaacg atcccgggaa    240

catgtccttt gtgaaggaga cggtggacaa gctgttgaaa ggctacgaca ttcgcctaag    300

acccgacttc gggggtcccc cggtctgcgt ggggatgaac atcgacatcg ccagcatcga    360

catggtttcc gaagtcaaca tggattatac cttaaccatg tattttcaac aatattggag    420

agataaaagg ctcgcctatt ctgggatccc tctcaacctc acgcttgaca atcgagtggc    480

tgaccagcta tgggtgcccg acacatattt cttaaatgac aaaaagtcat ttgtgcatgg    540

agtgacagtg aaaaaccgca tgatccgtct tcaccctgat gggacagtgc tgtatgggct    600

cagaatcacc acgacagcag catgcatgat ggacctcagg agataccccc tggacgagca    660

gaactgcact ctggaaattg aaagctatgg ctacaccacg gatgacattg agttttactg    720

gcgaggcggg gacaaggctg ttaccggagt ggaaaggatt gagctcccgc agttctccat    780

cgtggagcac cgtctggtct cgaggaatgt tgtcttcgcc acaggtgcct atcctcgact    840

gtcactgagc tttcggttga agaggaacat tggatacttc attcttcaga cttatatgcc    900

ctctatactg ataacgattc tgtcgtgggt gtccttctgg atcaattatg atgcatctgc    960

tgctagagtt gccctcggga tcacaactgt gctgacaatg acaaccatca acacccacct   1020

tcgggagacc ttgcccaaaa tcccctatgt caaagccatt gacatgtacc ttatgggctg   1080

cttcgtcttt gtgttcctgg cccttctgga gtatgccttt gtcaactaca ttttctttgg   1140

aagaggccct caaaggcaga agaagcttgc agaaaagaca gccaaggcaa agaatgaccg   1200

ttcaaagagc gaaagcaacc gggtggatgc tcatggaaat attctgttga catcgctgga   1260

agttcacaat gaaatgaatg aggtctcagg cggcattggc gataccagga attcagcaat   1320

atcctttgac aactcaggaa tccagtacag gaaacagagc atgcctcgag aagggcatgg   1380

gcgattcctg ggggacagaa gcctcccgca caagaagacc catctacgga ggaggtcttc   1440

acagctcaaa attaaaatac ctgatctaac cgatgtgaat gccatagaca gatggtccag   1500

gatcgtgttt ccattcactt tttctctttt caacttagtt tactggctgt actatgttaa   1560

ctgagtgact gtacttgatt tttcaaagac ttcatttaac actgagtgaa atattactct   1620

gcctgtcaag tttttatacc tgtacacaca cagacacaca agcagacaca cacatatata   1680

catacgcaat tgtatatata tgtgaacttt ctcagcatat atataaaata cacgtgtata   1740

tgaggatgta tgtgtatatg tttatacaca caggagtcag tgcccatgtg tatggaagac   1800

aaatacacat acatatatac attttgcagc tatggacaat ttaccacagg atgcatatta   1860

aagaaagtca tagttttttt cttttttaat tgaaagggac aagtatcatc taaatattat   1920

gccttgagaa tgagggcgtg aaacacaata tcatccccaa atgtgtcttg tattatcata   1980

agttagatgt tttagtttaa aaatcagaaa gacattctta gttaatcttt gaaaactcat   2040

acagtggtat tgctagttta aaatgagtca cttacttcat atcctctcgt tcagtttagt   2100

aagcaaaggc ttcttggctt ctctggtgat ggggtttgtt ttcatcgggc atacgttttc   2160

tgcaatggtt tagtggctgg ggtgagccac tggcagtgtg cttacctgtt gtctgaaaca   2220

tagatagatc ccacgttgat gtctgaacga ccgtcttttg aaaactcatc gggagtgaat   2280

ggcatctcgt tgtaagtact ctaatataca gtgtgtagtt tgtttctgtt gttcacttgg   2340

agtggatcca gcttcactgt catgtgcgaa cacagtgaca cgtttggcca gtgacatttc   2400

aatcactgaa aatgtgctct acatctcgta tggatttcta ggcctgatat ccaacagaaa   2460

gcatagacgt ctcaggttat tcgttactct aaggtaaaac catctaggat gattttcccc   2520

cttgcagtta tgttatcatt cttataacat tgtatgttaa tagaaaatat atttgcataa   2580

tatgcatata tatgtatatt taccaagatt ttgtttctta cgcttgctat catggcagca   2640

tgcgatgtca tattttcctt tatgtgatgt aactactttc tgttatctag aaattaagat   2700

tgaagctaaa acacttctac tgttcaattt cagaaactaa gaatcatcct catgccttta   2760

tttctgtatc tgacatattt cataagcaca tccaactact cctagactga ctaggattct   2820

gcaggaacat gacccgtaca caccacgcgt cacccaacga cccatgaccg ttctctgagg   2880

caaaggaggg caacctgaca gcaaacacag tcactgttgg ttccttctga tccacagcct   2940

catcagtatt tggacttttt aaagctcgta gaaacaagac aaggtgcacc ggtttcatag   3000

acgcaacctt aacttactat ttagatgaga tctttctaaa gaaaaaaaaa agagatgata   3060

tattttttgt aaacaatatt tctatcacag gcatccataa actgaaatga ctacagttgt   3120

gcaaacaggt gtcacagtga agttgagcat ttggagaaaa aaataaaaag caaaatttgc   3180

aggaagaact gctaaattaa tactttatcc caaaatgcca cgtatgcctc accctctctg   3240

ttctatccaa aaccaaggac cagagtgctc caatggtagg ccccagttgt ctcgatgtag   3300

gtagaggcac caccctcccc gaggatgcgt gtggtgtgga ctatccccat gagctgacca   3360

ctacttgatt tttctttggt ggccgtaaca acctttaatt tgtgggcatc tgcaacagtt   3420

caaaacccac catcagataa aacataatcc acaaaatctc acgctagagg caattaccta   3480

cttttagacc cttttccctc tttcattcct atctttttcc tcctaatcgc tgctctctgg   3540

ttttattttc atctggagac tagccaggga tttctttggc tttggctttt ctctgaccat   3600

tttttccatg ggtaacaatg ggggatccta aaagttaaac agattgggaa aaaccttgtt   3660

aagtggcctt atcattatta tcatgttaaa gaaaaaaaat acatttgcaa agaccttatc   3720

cctttcaata cttcaggtat ctttttctgt atccagtaat taaaggtgtg aggtccacat   3780

gcagaagagg gaccccaaaa tgtaaatgga tgtggacaaa aacagtcaat ggtctattta   3840

agtgtataat ttatactatt cagaactgtg acattaattc tttctgggag aaaagtgatt   3900

taaaactttt ttgatgcata gttgaggtac ccaaatatca aaggcagaga ccccatgggg   3960

ctccaaagag ctgcagtctc cttcccaagg ttttctggat ataaatttgc atggtatagt   4020

cataatagct tttgagcttt ttatatgcat ttggcaccaa gactgggatc cacaactttg   4080

tagacactgc gatgaagtta acatattagc tatactataa atagtgtttg taactacaca   4140

cacacacaca cacacacaca caaatacata catatattct gtaaaaacaa aaaaaaactt   4200

tttaagatcc ttgggtatgt gtttgcttta ctccatttca gaagaaaatt acttttcttc   4260

taacaaaatt attttatagc ttctccattt ttaaaacttg tgagagcatt gagaagagaa   4320

ctctgactgt gttaacagaa gagagttgaa ttggagtctc tgttgtgtta aaatgacctc   4380

tcgttactcc acagtagtta tttgagccag tgactgagtc gcgttgagga attctgaacc   4440

cggacctctg acgttgttgg gaggtggctg ttacccacac ccagacctct tgagtaagga   4500

cagaaacgtt atcattgggg atataatgag atttctttct taacaattga aagtaataaa   4560

gagttaattt tctcagtagt cctgtctttc caaaatgcgc cacaggggct caagatctac   4620

agaagaatct tgttatgaca gtttgttatt acccatattc agatatcctt gagataatgg   4680

aagagccctg ctacataact ccctacagag aaagactgat agacttgagt agtccttaaa   4740

acaagtgtta ttcctgttca ccaaccccgg gactgtggag gggtttcact gtctatacca   4800

tgcgacatcc atttcccctg aatctcaaac gaactagaaa gtatgtcatg ataatatttc   4860

cattagattt ggaagctacc tgtacatctg caatattgtg tttttaacgc cagcacccag   4920

aactttgaca tgttcagtca ctccctgaaa ggcacttctc tcttgtccaa acacagcgtt   4980

gacattttta ctgaggagat catctcaaag gtgatgccaa acgagtctgg ggctggtttt   5040

aaggggacag gcacattgca gttgtaggtg ttcattttca gcatctagta gataatccat   5100

tggtgtttgt cccaccattg gtgtattcta acaagaatgt gtccaacttt gaatctcctg   5160

gcttgaaagt ataaaccatc acttaattct tattttaact ctccacctga aaaccagttc   5220

atatttctgg ccattttatg taagcaaaac tgaacaattg gtgaaacatt ttgttactct   5280

tggaattgac tctggctgtc agtgtgagcc attagagtaa catcgaatct tggggcaaag   5340

aactgcccag gtgaattaaa tttttccagg acactagcta gtgtgccttg gattgattac   5400

ctcttctact gcattgaaag gcgccatgtt ttcctgaaat actaaattcc caacacctgg   5460

gtaaacaatg accttccaga gagtggctcc cgtatgcctc tccctaggac caaccccatg   5520

aacatgtttt gtcacgtttg tctcatgttt ctacttcaca agtcagtgag tgtgtttaag   5580

gtaagtacag gattattcta gtaggaatag gcgattgctg tcataatcaa ttctcatgtt   5640

gatttcattt tattgtaaag ataaatttaa acccagtttt gcttaagcac attgatgtaa   5700

ttttttggta ttatttgaca tgaaaaaaca gcaaaattga gtgatagata caatatgaaa   5760

cttgttgatg aatgaattca aatttattaa aaaaggagta actgacctaa a            5811


<210>  330
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Trp Gly Leu Ala Gly Gly Arg Leu Phe Gly Ile Phe Ser Ala Pro 
1               5                   10                  15      


Val Leu Val Ala Val Val Cys Cys Ala Gln Ser Val Asn Asp Pro Gly 
            20                  25                  30          


Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
        35                  40                  45              


Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
    50                  55                  60                  


Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                85                  90                  95      


Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                 105                 110         


Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                 120                 125             


Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                 135                 140                 


Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                 170                 175     


Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                 185                 190         


Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
        195                 200                 205             


Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
    210                 215                 220                 


Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                 230                 235                 240 


Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu 
                245                 250                 255     


Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
            260                 265                 270         


Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
        275                 280                 285             


Ile Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
    290                 295                 300                 


Ala Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro 
                325                 330                 335     


Gln Arg Gln Lys Lys Leu Ala Glu Lys Thr Ala Lys Ala Lys Asn Asp 
            340                 345                 350         


Arg Ser Lys Ser Glu Ser Asn Arg Val Asp Ala His Gly Asn Ile Leu 
        355                 360                 365             


Leu Thr Ser Leu Glu Val His Asn Glu Met Asn Glu Val Ser Gly Gly 
    370                 375                 380                 


Ile Gly Asp Thr Arg Asn Ser Ala Ile Ser Phe Asp Asn Ser Gly Ile 
385                 390                 395                 400 


Gln Tyr Arg Lys Gln Ser Met Pro Arg Glu Gly His Gly Arg Phe Leu 
                405                 410                 415     


Gly Asp Arg Ser Leu Pro His Lys Lys Thr His Leu Arg Arg Arg Ser 
            420                 425                 430         


Ser Gln Leu Lys Ile Lys Ile Pro Asp Leu Thr Asp Val Asn Ala Ile 
        435                 440                 445             


Asp Arg Trp Ser Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn 
    450                 455                 460                 


Leu Val Tyr Trp Leu Tyr Tyr Val Asn 
465                 470             


<210>  331
<211>  3653
<212>  DNA
<213>  Homo sapiens

<400>  331
gcgctcggcg cccaccaggc ggacgcccag gagaacccct gcctccgtcg cggctcctgg     60

agagctgatc gttcacctgc cccggcccgc ctgaggacgg gggtgccttc atgcggcccc    120

cacactcctc accccgccgc cgccgccgtc cccgagctcc gcacagtgcg ccccagcccc    180

agcagggcgc acaactttgg aagtctcgcg gcgctccgag aggcggcaga gtccgcgccc    240

cagccccggg ccgggccggg ccagaaccgc agcgtctggg ggaagccaga gagtcggtaa    300

tcgcttcggg gatgtaaggc gacagacata ggacccccga gctcgcatca gcacccttcg    360

gctgcctccc ggggtggggg cgggccccgc acacggtaag acctcttgct ttcgctcagg    420

ctcaagattc aagatacaga tattgatatg tatatatata tttaatttcc tgtcatcctt    480

ccaagttatc aggccaccga tgatttttgt tctcccttct tgaagaataa atctctcttt    540

acccatcggc tctccctact ctctcccgcc gcttagaaat aaaacttggc tgtattagga    600

gctcggagca agaaggcgcc caccgagagc gtctgaagcg cgagccaggc gcagttcgcg    660

ggacccgggc catgggccgc tagcggtcct ccagttcggg cccggcctcc ctgcggcccc    720

ctccctatgt gagccgcagc caggcgagcg gggcgccgga ggaagaggag gacccacggg    780

cgccgggccg gaaggcagct ggcagcaggc ccaggccagc gggcgcccgc gttcatgttc    840

cgccaggagc agccgttggc cgagggcagc tttgcgccca tgggctccct gcagccggac    900

gcgggcaacg cgagctggaa cgggaccgag gcgccggggg gcggcgcccg ggccacccct    960

tactccctgc aggtgacgct gacgctggtg tgcctggccg gcctgctcat gctgctcacc   1020

gtgttcggca acgtgctcgt catcatcgcc gtgttcacga gccgcgcgct caaggcgccc   1080

caaaacctct tcctggtgtc tctggcctcg gccgacatcc tggtggccac gctcgtcatc   1140

cctttctcgc tggccaacga ggtcatgggc tactggtact tcggcaaggc ttggtgcgag   1200

atctacctgg cgctcgacgt gctcttctgc acgtcgtcca tcgtgcacct gtgcgccatc   1260

agcctggacc gctactggtc catcacacag gccatcgagt acaacctgaa gcgcacgccg   1320

cgccgcatca aggccatcat catcaccgtg tgggtcatct cggccgtcat ctccttcccg   1380

ccgctcatct ccatcgagaa gaagggcggc ggcggcggcc cgcagccggc cgagccgcgc   1440

tgcgagatca acgaccagaa gtggtacgtc atctcgtcgt gcatcggctc cttcttcgct   1500

ccctgcctca tcatgatcct ggtctacgtg cgcatctacc agatcgccaa gcgtcgcacc   1560

cgcgtgccac ccagccgccg gggtccggac gccgtcgccg cgccgccggg gggcaccgag   1620

cgcaggccca acggtctggg ccccgagcgc agcgcgggcc cggggggcgc agaggccgaa   1680

ccgctgccca cccagctcaa cggcgcccct ggcgagcccg cgccggccgg gccgcgcgac   1740

accgacgcgc tggacctgga ggagagctcg tcttccgacc acgccgagcg gcctccaggg   1800

ccccgcagac ccgagcgcgg tccccggggc aaaggcaagg cccgagcgag ccaggtgaag   1860

ccgggcgaca gcctgccgcg gcgcgggccg ggggcgacgg ggatcgggac gccggctgca   1920

gggccggggg aggagcgcgt cggggctgcc aaggcgtcgc gctggcgcgg gcggcagaac   1980

cgcgagaagc gcttcacgtt cgtgctggcc gtggtcatcg gagtgttcgt ggtgtgctgg   2040

ttccccttct tcttcaccta cacgctcacg gccgtcgggt gctccgtgcc acgcacgctc   2100

ttcaaattct tcttctggtt cggctactgc aacagctcgt tgaacccggt catctacacc   2160

atcttcaacc acgatttccg ccgcgccttc aagaagatcc tctgtcgggg ggacaggaag   2220

cggatcgtgt gaggtttccg ctggcgcccg cgtagactca cgctgactgc aggcagcggg   2280

gggcatcgag gggtgcttag ccccagggca ctcagaaacc cgggcgctgc ctgctctgcg   2340

tttcctcgtc tggggtggct ctgcagcctc ctgcgggcgg gcgtctgctg ctcctacaag   2400

ggaagcttct tgctgccagg cccacacatc cccagttgtt ggtttggcca ctcttgacct   2460

ggagccatct tcctagtggg ccacccctaa tcactattgc ttcctaaagg tattttcacc   2520

ctcttcgcct ggtacagccc tcacagctct tcagagcaag cactggacta caagggcatg   2580

gctcacaaaa ggttaatgga tgggggttac ctagccctgg ctaattcccc ttccattccc   2640

aactctctct ctctttttga agaaaaatgc taagggcagc cctgcctgcc ctccccatcc   2700

cccgctgtaa atatacacta tttttgatag cacacatggg gcccccatat ctcttggcct   2760

tggttttgat gttgaaatcc tggccttggg agagatgcct tccaggcaga cacagctgtc   2820

tggttcaggc caagcccctt tgcaatgcaa gccctttctg gtgttatgaa gtccctctat   2880

gtcgtcgttt tcaccagcaa ctggtgactg tcccttcgac acggacctgc tttgagattt   2940

cctgacaggg aaaagatttc tgtccatttt tttcctgtgc ctaacagcat aattgccttt   3000

tcctatgtaa atattatgat ggtggatcaa gacataagta aatgagcctt tctgcctcac   3060

atcagccctg tgtataaagc cattattctc tgatgcactg tttgccccag taactcactt   3120

taaaacctct ctttccagtg ttccctctct ccctccaggg ccactgcttg aagaagaata   3180

tgtatgtttc tatcttgtat gtctgtgtgc ccctcctgcc ccgaaagtgc tgactatggg   3240

gaaatctttt agctgctgtt tttagactcc aaggagtgga aattatgtgg aagaagcaaa   3300

cctgatacaa tttgcccaag gtaaacagtt tgaaaagaca aatgggcctg ccaaactgta   3360

cagtttcttc cccaagagct gttaggtatc aaaatgttgt cctttccccc ctccgtgctt   3420

ttctggttga gatcatgtca ttgatgaact gccaaagtca ggggaggagg gcagagactt   3480

tgtgtttaca tctgcatttc tacatgtttt agacagagac aatttaaggc ctgcactctt   3540

atttcactaa agaaaaacta atgtcagcac atgttgctaa tgacagtgga ttttttttta   3600

aataaaaaag tttacagatc aaatgtgaaa taaatatgaa tggagtggtc aaa          3653


<210>  332
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Gly Ser Leu Gln Pro Asp Ala Gly Asn Ala Ser Trp Asn Gly Thr 
1               5                   10                  15      


Glu Ala Pro Gly Gly Gly Ala Arg Ala Thr Pro Tyr Ser Leu Gln Val 
            20                  25                  30          


Thr Leu Thr Leu Val Cys Leu Ala Gly Leu Leu Met Leu Leu Thr Val 
        35                  40                  45              


Phe Gly Asn Val Leu Val Ile Ile Ala Val Phe Thr Ser Arg Ala Leu 
    50                  55                  60                  


Lys Ala Pro Gln Asn Leu Phe Leu Val Ser Leu Ala Ser Ala Asp Ile 
65                  70                  75                  80  


Leu Val Ala Thr Leu Val Ile Pro Phe Ser Leu Ala Asn Glu Val Met 
                85                  90                  95      


Gly Tyr Trp Tyr Phe Gly Lys Ala Trp Cys Glu Ile Tyr Leu Ala Leu 
            100                 105                 110         


Asp Val Leu Phe Cys Thr Ser Ser Ile Val His Leu Cys Ala Ile Ser 
        115                 120                 125             


Leu Asp Arg Tyr Trp Ser Ile Thr Gln Ala Ile Glu Tyr Asn Leu Lys 
    130                 135                 140                 


Arg Thr Pro Arg Arg Ile Lys Ala Ile Ile Ile Thr Val Trp Val Ile 
145                 150                 155                 160 


Ser Ala Val Ile Ser Phe Pro Pro Leu Ile Ser Ile Glu Lys Lys Gly 
                165                 170                 175     


Gly Gly Gly Gly Pro Gln Pro Ala Glu Pro Arg Cys Glu Ile Asn Asp 
            180                 185                 190         


Gln Lys Trp Tyr Val Ile Ser Ser Cys Ile Gly Ser Phe Phe Ala Pro 
        195                 200                 205             


Cys Leu Ile Met Ile Leu Val Tyr Val Arg Ile Tyr Gln Ile Ala Lys 
    210                 215                 220                 


Arg Arg Thr Arg Val Pro Pro Ser Arg Arg Gly Pro Asp Ala Val Ala 
225                 230                 235                 240 


Ala Pro Pro Gly Gly Thr Glu Arg Arg Pro Asn Gly Leu Gly Pro Glu 
                245                 250                 255     


Arg Ser Ala Gly Pro Gly Gly Ala Glu Ala Glu Pro Leu Pro Thr Gln 
            260                 265                 270         


Leu Asn Gly Ala Pro Gly Glu Pro Ala Pro Ala Gly Pro Arg Asp Thr 
        275                 280                 285             


Asp Ala Leu Asp Leu Glu Glu Ser Ser Ser Ser Asp His Ala Glu Arg 
    290                 295                 300                 


Pro Pro Gly Pro Arg Arg Pro Glu Arg Gly Pro Arg Gly Lys Gly Lys 
305                 310                 315                 320 


Ala Arg Ala Ser Gln Val Lys Pro Gly Asp Ser Leu Pro Arg Arg Gly 
                325                 330                 335     


Pro Gly Ala Thr Gly Ile Gly Thr Pro Ala Ala Gly Pro Gly Glu Glu 
            340                 345                 350         


Arg Val Gly Ala Ala Lys Ala Ser Arg Trp Arg Gly Arg Gln Asn Arg 
        355                 360                 365             


Glu Lys Arg Phe Thr Phe Val Leu Ala Val Val Ile Gly Val Phe Val 
    370                 375                 380                 


Val Cys Trp Phe Pro Phe Phe Phe Thr Tyr Thr Leu Thr Ala Val Gly 
385                 390                 395                 400 


Cys Ser Val Pro Arg Thr Leu Phe Lys Phe Phe Phe Trp Phe Gly Tyr 
                405                 410                 415     


Cys Asn Ser Ser Leu Asn Pro Val Ile Tyr Thr Ile Phe Asn His Asp 
            420                 425                 430         


Phe Arg Arg Ala Phe Lys Lys Ile Leu Cys Arg Gly Asp Arg Lys Arg 
        435                 440                 445             


Ile Val 
    450 


<210>  333
<211>  4146
<212>  DNA
<213>  Homo sapiens

<400>  333
cggtccgttg ttcatttgcc attcgacctc cgccagggcc tggtcggacg gaaacgctcc     60

gccggcttta ttgtcgcttc gttatgtggc ggagccgagc agtttagcgt gcctctcacc    120

ctcagcgcct gcgaagccgg cggcggcgtc gggactcctc ggcgcgcgga ggaaggatat    180

ctgtgtggag gatcggtgtg tgcgcgcgcg gctttaaaga gggggcagcg gagggtctcc    240

ccgcactccg ctgctcaact tcgaaggcct cgctcgctgc aggctcgctc ctcacctctc    300

cgccgcccgc ccccttctcc gcgcgggacg ctgcccggag cgcggcgggg cgggggtgga    360

ggacgagaga gcggtcggag gcgtcggccc ggcagcggca gcggcagcgg acgcgtgcag    420

cagacccggg agcgagcgcg agccgggctg ccgggcgaga gggcgaggcc gagccccgcg    480

agaccggaac gccgggggcg ggggcgagac agagggggag ccgcggggag cgcgcgggac    540

gcggcccgag gccgtgcgcg agccggggca ccgggcggcg gcggcggcgg cgcgcgccat    600

gtcgttcagt gaaatgaacc gcaggacgct ggcgttccga ggaggcgggt tggtcaccgc    660

tagcggcggc ggctccacga acaataacgc tggcggggag gcctcagctt ggcctccgca    720

gccccagccg agacagcccc cgccgacagc gccgcccgcg cttcagccgc ctaatgggcg    780

gggggccgac gaggaagtgg aattggaggg cctggagccc caagacctgg aggcctccgc    840

cgggccggcc gccggcgccg ccgaggaagc caaggagttg ctgctccccc aagacgcggg    900

cggccccacc tcgcttggcg gtggcgcggg gggccccctg ctagcggaaa ggaaccgtcg    960

gactctggcc ttccgaggcg gcggcggcgg gggtctcggc aacaatggca gtagccgcgg   1020

ccgccccgag acctcggtgt ggcccttgag gcatttcaat gggcgagggc cggcgactgt   1080

ggatctggag ctggacgcgc tggaggggaa ggagttgata caggacggcg cgtccctgag   1140

cgacagcacc gaggacgagg aggagggggc gagcctgggc gacggcagcg gggcggaagg   1200

cggcagctgc agcagcagca ggcggtcggg cggcgatggc ggggacgaag tggagggcag   1260

cggtgtggga gctggcgaag gagagactgt ccagcacttc ccgctcgcgc ggcccaagtc   1320

tctaatgcag aagctccaat gctccttcca gacctcctgg ctcaaggact ttccctggct   1380

gcgctattcc aaggatactg gtcttatgtc ttgcggctgg tgccaaaaga cccctgcaga   1440

tgggggaagc gtggaccttc ccccagtggg gcatgatgag ctttcgcgag ggacccgcaa   1500

ctacaagaaa accctcctcc tgaggcacca cgtctctacc gagcacaaac tccacgaagc   1560

caacgcccca gagtcagaaa taccatcaga ggaggggtac tgggacttta ataggaggcc   1620

aaatgagaac tcttattgct atcaacttct gcgacaacta aatgaacaga gaaagaaagg   1680

tattctttgt gatgtcagca ttgtggtaag cggaaaaatc ttcaaagctc ataagaacat   1740

cctggttgca ggcagccgtt tctttaagac tttatattgc ttttcaaaca aagaaagccc   1800

taaccaaaac aatactaccc acttagatat tgctgcagtt caaggttttt cagtcatctt   1860

ggacttcttg tattctggta acctggtgct cacaagccaa aatgccattg aagttatgac   1920

cgtggccagc tatcttcaaa tgagtgaagt tgttcaaact tgccgaaatt tcattaaaga   1980

tgccttaaat ataagcatta aatcagaagc tccagagtct gtagttgtgg actataataa   2040

tagaaaacca gttaatagag atggtctgtc ttcatcacgg gatcaaaaaa ttgccagttt   2100

ttgggcaaca cggaatctta ccaatttggc aagtaatgta aagattgaaa atgatggttg   2160

taatgtcgac gagggccaaa tagaaaacta ccaaatgaat gacagtagtt gggtccagga   2220

tggatctcct gaaatggctg aaaatgaatc tgaaggtcaa acaaaagtgt ttatttggaa   2280

taatatgggc tcccagggaa ttcaagagac tggcaaaaca aggaggaaaa accaaactac   2340

aaaaagattt atttataata ttccacctaa taatgaaacg aatttagaag attgctcagt   2400

aatgcagcca cctgttgcct atccagaaga aaatacacta ctcatcaagg aagaaccaga   2460

tttagatggt gctctactct cggggccaga tggtgatagg aatgtgaatg caaatttatt   2520

ggctgaagct ggcactagtc aagatggagg tgatgctggt acttcacatg atttcaagta   2580

tggtttgatg cctggtcctt caaatgattt caagtatgga ttattgccag aatcttggcc   2640

aaaacaagaa acctgggaaa atggtgaatc atctctaatc atgaacaagt taaaatgccc   2700

tcattgtagc tatgtagcca aatacagacg aacactaaaa aggcacttgc tcattcacac   2760

aggagtgaga tcatttagct gtgatatttg tggaaaactg tttactcgaa gagaacatgt   2820

aaaaagacat tccctggtgc ataaaaagga taaaaaatac aaatgtatgg tgtgtaagaa   2880

gatcttcatg ttagcagcca gtgttggaat aagacatgga tctcgacgtt atggtgtttg   2940

tgtagactgt gcagataaat cacagccagg agggcaagaa ggtgtagatc agggacagga   3000

tacagaattc cctcgggatg aagaatacga ggagaatgaa gtaggagaag ctgatgaaga   3060

gctagttgat gatggagaag atcagaatga tccctctcga tgggatgaat caggagaagt   3120

ttgtatgtct ctagatgatt aactgaccta ctatactcct caaggatgct gcatttggac   3180

ctaatatgaa tcgacaattt ggattgttga acttgaaggc ttgcaaaata tggtacatgc   3240

tggatagtag ttatgttgct gtgaaaactg tagggtcaaa gccttatagc aaaaaaaatt   3300

tttttttata tttgcacagg actatacagc aaacaaccat gtggttggat tacatggagt   3360

ccccacatac tcagtcagtt atcaaagtaa aatatttttt atttatagga tatacagtaa   3420

ctatttgggt cctatgaaaa tagtccttaa agagcttaca ttcatgtgct actttaacat   3480

gaatggagaa aatccgttta tggaagtaca gtgacaattg acccaatcac tctgtccatc   3540

aaaccactca ggctagtttg tactagtaga gttttgtttc tatttttatt tttattaatt   3600

ttattttttt taatacagat tttcagtgag gggctttttc aatcccattg gttctatttt   3660

cttgtatttt tccatttaat ttgcttcata acttaaacca agtctcttct agtcttaggt   3720

attatttctc gattttgtgc tgatgggcat gtttataaga actggagagg taatttattg   3780

gaatgaacta actgacttcc tccattcccc tcttcctttt tgacatgaat tttactactt   3840

cacaaatgaa gaatgatgtt atgaagttag cttggcggag ttgacaaata ccactaaaat   3900

gattatgatt tagaagtaac tttcttctgc tgctctaatc tgataaatgg ttactatatg   3960

atattttctg acatggtatt tggttttggg tatctgttac tttggcacta ttcttgtttg   4020

cctctttatt tttgccagtg tactatacct cagtcctatt tgaaagacct aattgaaaga   4080

aaaatcatag aaataagtaa aatgatttgt tttataattt atccaccatg tccagtttgg   4140

ttagct                                                              4146


<210>  334
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Ser Phe Ser Glu Met Asn Arg Arg Thr Leu Ala Phe Arg Gly Gly 
1               5                   10                  15      


Gly Leu Val Thr Ala Ser Gly Gly Gly Ser Thr Asn Asn Asn Ala Gly 
            20                  25                  30          


Gly Glu Ala Ser Ala Trp Pro Pro Gln Pro Gln Pro Arg Gln Pro Pro 
        35                  40                  45              


Pro Thr Ala Pro Pro Ala Leu Gln Pro Pro Asn Gly Arg Gly Ala Asp 
    50                  55                  60                  


Glu Glu Val Glu Leu Glu Gly Leu Glu Pro Gln Asp Leu Glu Ala Ser 
65                  70                  75                  80  


Ala Gly Pro Ala Ala Gly Ala Ala Glu Glu Ala Lys Glu Leu Leu Leu 
                85                  90                  95      


Pro Gln Asp Ala Gly Gly Pro Thr Ser Leu Gly Gly Gly Ala Gly Gly 
            100                 105                 110         


Pro Leu Leu Ala Glu Arg Asn Arg Arg Thr Leu Ala Phe Arg Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Leu Gly Asn Asn Gly Ser Ser Arg Gly Arg Pro Glu 
    130                 135                 140                 


Thr Ser Val Trp Pro Leu Arg His Phe Asn Gly Arg Gly Pro Ala Thr 
145                 150                 155                 160 


Val Asp Leu Glu Leu Asp Ala Leu Glu Gly Lys Glu Leu Ile Gln Asp 
                165                 170                 175     


Gly Ala Ser Leu Ser Asp Ser Thr Glu Asp Glu Glu Glu Gly Ala Ser 
            180                 185                 190         


Leu Gly Asp Gly Ser Gly Ala Glu Gly Gly Ser Cys Ser Ser Ser Arg 
        195                 200                 205             


Arg Ser Gly Gly Asp Gly Gly Asp Glu Val Glu Gly Ser Gly Val Gly 
    210                 215                 220                 


Ala Gly Glu Gly Glu Thr Val Gln His Phe Pro Leu Ala Arg Pro Lys 
225                 230                 235                 240 


Ser Leu Met Gln Lys Leu Gln Cys Ser Phe Gln Thr Ser Trp Leu Lys 
                245                 250                 255     


Asp Phe Pro Trp Leu Arg Tyr Ser Lys Asp Thr Gly Leu Met Ser Cys 
            260                 265                 270         


Gly Trp Cys Gln Lys Thr Pro Ala Asp Gly Gly Ser Val Asp Leu Pro 
        275                 280                 285             


Pro Val Gly His Asp Glu Leu Ser Arg Gly Thr Arg Asn Tyr Lys Lys 
    290                 295                 300                 


Thr Leu Leu Leu Arg His His Val Ser Thr Glu His Lys Leu His Glu 
305                 310                 315                 320 


Ala Asn Ala Pro Glu Ser Glu Ile Pro Ser Glu Glu Gly Tyr Trp Asp 
                325                 330                 335     


Phe Asn Arg Arg Pro Asn Glu Asn Ser Tyr Cys Tyr Gln Leu Leu Arg 
            340                 345                 350         


Gln Leu Asn Glu Gln Arg Lys Lys Gly Ile Leu Cys Asp Val Ser Ile 
        355                 360                 365             


Val Val Ser Gly Lys Ile Phe Lys Ala His Lys Asn Ile Leu Val Ala 
    370                 375                 380                 


Gly Ser Arg Phe Phe Lys Thr Leu Tyr Cys Phe Ser Asn Lys Glu Ser 
385                 390                 395                 400 


Pro Asn Gln Asn Asn Thr Thr His Leu Asp Ile Ala Ala Val Gln Gly 
                405                 410                 415     


Phe Ser Val Ile Leu Asp Phe Leu Tyr Ser Gly Asn Leu Val Leu Thr 
            420                 425                 430         


Ser Gln Asn Ala Ile Glu Val Met Thr Val Ala Ser Tyr Leu Gln Met 
        435                 440                 445             


Ser Glu Val Val Gln Thr Cys Arg Asn Phe Ile Lys Asp Ala Leu Asn 
    450                 455                 460                 


Ile Ser Ile Lys Ser Glu Ala Pro Glu Ser Val Val Val Asp Tyr Asn 
465                 470                 475                 480 


Asn Arg Lys Pro Val Asn Arg Asp Gly Leu Ser Ser Ser Arg Asp Gln 
                485                 490                 495     


Lys Ile Ala Ser Phe Trp Ala Thr Arg Asn Leu Thr Asn Leu Ala Ser 
            500                 505                 510         


Asn Val Lys Ile Glu Asn Asp Gly Cys Asn Val Asp Glu Gly Gln Ile 
        515                 520                 525             


Glu Asn Tyr Gln Met Asn Asp Ser Ser Trp Val Gln Asp Gly Ser Pro 
    530                 535                 540                 


Glu Met Ala Glu Asn Glu Ser Glu Gly Gln Thr Lys Val Phe Ile Trp 
545                 550                 555                 560 


Asn Asn Met Gly Ser Gln Gly Ile Gln Glu Thr Gly Lys Thr Arg Arg 
                565                 570                 575     


Lys Asn Gln Thr Thr Lys Arg Phe Ile Tyr Asn Ile Pro Pro Asn Asn 
            580                 585                 590         


Glu Thr Asn Leu Glu Asp Cys Ser Val Met Gln Pro Pro Val Ala Tyr 
        595                 600                 605             


Pro Glu Glu Asn Thr Leu Leu Ile Lys Glu Glu Pro Asp Leu Asp Gly 
    610                 615                 620                 


Ala Leu Leu Ser Gly Pro Asp Gly Asp Arg Asn Val Asn Ala Asn Leu 
625                 630                 635                 640 


Leu Ala Glu Ala Gly Thr Ser Gln Asp Gly Gly Asp Ala Gly Thr Ser 
                645                 650                 655     


His Asp Phe Lys Tyr Gly Leu Met Pro Gly Pro Ser Asn Asp Phe Lys 
            660                 665                 670         


Tyr Gly Leu Leu Pro Glu Ser Trp Pro Lys Gln Glu Thr Trp Glu Asn 
        675                 680                 685             


Gly Glu Ser Ser Leu Ile Met Asn Lys Leu Lys Cys Pro His Cys Ser 
    690                 695                 700                 


Tyr Val Ala Lys Tyr Arg Arg Thr Leu Lys Arg His Leu Leu Ile His 
705                 710                 715                 720 


Thr Gly Val Arg Ser Phe Ser Cys Asp Ile Cys Gly Lys Leu Phe Thr 
                725                 730                 735     


Arg Arg Glu His Val Lys Arg His Ser Leu Val His Lys Lys Asp Lys 
            740                 745                 750         


Lys Tyr Lys Cys Met Val Cys Lys Lys Ile Phe Met Leu Ala Ala Ser 
        755                 760                 765             


Val Gly Ile Arg His Gly Ser Arg Arg Tyr Gly Val Cys Val Asp Cys 
    770                 775                 780                 


Ala Asp Lys Ser Gln Pro Gly Gly Gln Glu Gly Val Asp Gln Gly Gln 
785                 790                 795                 800 


Asp Thr Glu Phe Pro Arg Asp Glu Glu Tyr Glu Glu Asn Glu Val Gly 
                805                 810                 815     


Glu Ala Asp Glu Glu Leu Val Asp Asp Gly Glu Asp Gln Asn Asp Pro 
            820                 825                 830         


Ser Arg Trp Asp Glu Ser Gly Glu Val Cys Met Ser Leu Asp Asp 
        835                 840                 845         


<210>  335
<211>  3938
<212>  DNA
<213>  Homo sapiens

<400>  335
ttgtcacacc gacctgcacc atctctcgcc tgcctgtggg gtttctgtca actagtcgtg     60

gagggaagga gactctttaa agaataacat cttattgtgg ccatgccaga acccactaag    120

aaagaggaaa atgaagtgcc agccccagcc ccacccccgg aagaaccaag taaagagaag    180

gaggccggaa ctacaccagc aaaagatgaa gaggaagtct ccccgcctag cgccttgcct    240

ccaggtttgg gtagtcgggc cctggagaga aaagattcag actggaccct tgtcgaaact    300

cctcctgggg aggaacaagc caagcagaat gccaactccc agctgtccat cttgttcatt    360

gaaaaacctc aaggaggaac agtgaaagtt ggtgaagata tcaccttcat agccaaagtc    420

aaggctgaag atcttctgag aaaacccact atcaaatggt tcaaaggaaa atggatggac    480

ctggccagca aagccgggaa gcaccttcag ctgaaggaaa cctttgagag gcacagtcgg    540

gtgtacacat ttgagatgca gatcatcaag gccaaagata actttgcagg aaattacaga    600

tgcgaggtca cctataagga taagtttgac agctgttcat ttgatcttga agtgcacgaa    660

tctactggga ctactccaaa cattgacatc agatctgctt tcaagagaag tggagaaggt    720

caagaggatg caggagaact tgactttagt ggtctcctga aacgtaggga ggtgaagcag    780

caggaggaag aaccccaggt ggacgtatgg gagttgctga agaacgcgaa acccagtgag    840

tacgagaaga tcgccttcca gtatggaatc accgacctgc gcggcatgct caagcgactc    900

aagcgcatgc gcagagagga gaagaagagc gcagcttttg caaaaattct tgatcctgca    960

tatcaggttg acaaaggagg cagagtgagg tttgttgtgg agctggcaga tccaaagttg   1020

gaggtgaaat ggtataaaaa tggtcaagaa attcgaccca gtaccaaata catctttgaa   1080

cacaaaggat gccagagaat cctgtttatc aataactgtc agatgacaga tgattcagag   1140

tattatgtga cagccggtga tgagaaatgt tccactgagc tcttcgtaag agagcctcca   1200

attatggtga ccaaacagct ggaagataca actgcttatt gtggggagag agtggaatta   1260

gaatgtgagg tgtctgaaga tgatgccaat gtaaaatggt ttaagaatgg tgaagagatt   1320

atccctggtc caaaatcaag ataccgaatt agagttgagg gtaaaaaaca catcttgatc   1380

atagagggag caacaaaggc tgatgctgca gaatattcag taatgacaac aggaggacaa   1440

tcatctgcta aacttagtgt tgacttgaaa cctctgaaga ttttgacacc tctgactgat   1500

cagactgtaa atcttggaaa agaaatctgc ctgaagtgtg aaatctctga aaacatacca   1560

ggaaaatgga ctaaaaatgg cctacctgtt caggagagtg accgtctaaa ggtggttcac   1620

aagggaagga tccacaagtt agtgatagcc aatgccctca ctgaagatga aggtgattat   1680

gtatttgcac ctgatgccta caatgttact ctgcctgcca aagttcatgt tattgatcct   1740

cctaagatca tcctggatgg tcttgatgct gacaacacag tgacagtgat tgcaggaaac   1800

aagcttcgtc ttgagatccc catcagcgga gaaccacctc ctaaagccat gtggagccgg   1860

ggagataagg ctattatgga aggcagtggc cggataagaa cagaatctta ccctgatagc   1920

agcactctgg tcattgatat agctgaaaga gatgactctg gtgtttacca catcaatctg   1980

aaaaacgaag ctggagaggc acatgcaagc atcaaggtta aagttgtgga cttccctgat   2040

cctccagtgg caccgactgt gacagaggtg ggagatgact ggtgtatcat gaactgggag   2100

cctcctgcct acgacggagg ctctccaatc ctaggatatt ttattgagag gaagaagaaa   2160

caaagctcca ggtggatgag gctgaatttt gatctctgca aagaaacaac ttttgagccc   2220

aagaagatga ttgaaggtgt ggcctatgag gtccgcatct ttgcagtcaa tgccattggc   2280

atctccaagc ccagtatgcc ctccaggcct tttgttcctt tggctgtaac aagccctcct   2340

actcttctga ctgtggactc tgtcactgac acgactgtca cgatgaggtg gcgcccccca   2400

gaccacattg gtgcagcagg tttagatggc tatgtgctag agtattgctt tgaaggaact   2460

gaggactgga tagttgcaaa caaagatctg attgacaaga cgaagttcac catcacaggt   2520

ctgccaacag atgcaaagat ctttgtgcgt gtgaaggctg ttaatgcagc tggtgccagc   2580

gagcccaagt actattctca gcccattctc gtgaaggaaa tcatagaacc tccaaagatt   2640

cgcattccaa gacacctgaa gcaaacctat atccgcagag ttggagaagc tgtcaatctg   2700

gttatacctt tccagggaaa accaagacca gaattaactt ggaagaagga tggtgcagaa   2760

attgataaga atcaaataaa cattcgcaac tctgagactg atacaatcat atttattaga   2820

aaagcagaga ggagccactc tgggaaatat gatctgcaag tcaaagtgga caaattcgtg   2880

gagaccgcat caattgacat ccagatcatt gaccgtccag gtccacccca aattgtgaag   2940

attgaggatg tctggggaga aaatgtcgct ctcacatgga ctccaccaaa ggatgatgga   3000

aatgctgcta tcacaggcta taccattcag aaggctgaca agaagagcat ggaatggttt   3060

actgtcattg agcattatca tcgaaccagt gccaccatta ctgaattggt catagggaat   3120

gaatattact tccgggtctt ttctgaaaac atgtgtggcc tcagtgagga tgccaccatg   3180

actaaagaga gtgcagtgat cgccagggat ggtaaaatct acaaaaatcc agtgtatgaa   3240

gactttgatt tctcagaggc acccatgttt actcagcctt tggttaacac ctatgccata   3300

gctggttaca atgccaccct aaactgcagt gtgagaggaa atcctaagcc taaaataacc   3360

tggatgaaaa acaaagttgc tattgtggat gatccaagat acaggatgtt cagcaaccag   3420

ggagtctgta ccctggaaat tcgcaagccc agcccctatg atggaggcac ttactgctgc   3480

aaagcagtca atgaccttgg gacagtggag attgaatgca aactggaggt gaaagtgata   3540

tatcaaggag taaatacccc tggacaacca gtcttcctgg aggggcagca acagtcattg   3600

cacaataagg atttttgaat gtataatatc atctaaggtg ggctctcctt ctgcagactc   3660

ctcttgcaag gcgtacctcc aaacataatt gattcgtatc tgcgagactt acactcaagc   3720

aatcctgagg aatactgagg gagggcctgg ctactgtctc tctgcactct gctgctttga   3780

aatctggttg aaatgagaaa aagcattttc tgttttccca ccaggccccc aagtgtggtc   3840

tttttctttc ctcctaatgt tgaagagaaa aaaaaaaaaa aaagtttgcc cagattgctt   3900

aattaaaaat tgcaaacaaa atctcatttg aagtcaaa                           3938


<210>  336
<211>  1171
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Pro Glu Pro Thr Lys Lys Glu Glu Asn Glu Val Pro Ala Pro Ala 
1               5                   10                  15      


Pro Pro Pro Glu Glu Pro Ser Lys Glu Lys Glu Ala Gly Thr Thr Pro 
            20                  25                  30          


Ala Lys Asp Glu Glu Glu Val Ser Pro Pro Ser Ala Leu Pro Pro Gly 
        35                  40                  45              


Leu Gly Ser Arg Ala Leu Glu Arg Lys Asp Ser Asp Trp Thr Leu Val 
    50                  55                  60                  


Glu Thr Pro Pro Gly Glu Glu Gln Ala Lys Gln Asn Ala Asn Ser Gln 
65                  70                  75                  80  


Leu Ser Ile Leu Phe Ile Glu Lys Pro Gln Gly Gly Thr Val Lys Val 
                85                  90                  95      


Gly Glu Asp Ile Thr Phe Ile Ala Lys Val Lys Ala Glu Asp Leu Leu 
            100                 105                 110         


Arg Lys Pro Thr Ile Lys Trp Phe Lys Gly Lys Trp Met Asp Leu Ala 
        115                 120                 125             


Ser Lys Ala Gly Lys His Leu Gln Leu Lys Glu Thr Phe Glu Arg His 
    130                 135                 140                 


Ser Arg Val Tyr Thr Phe Glu Met Gln Ile Ile Lys Ala Lys Asp Asn 
145                 150                 155                 160 


Phe Ala Gly Asn Tyr Arg Cys Glu Val Thr Tyr Lys Asp Lys Phe Asp 
                165                 170                 175     


Ser Cys Ser Phe Asp Leu Glu Val His Glu Ser Thr Gly Thr Thr Pro 
            180                 185                 190         


Asn Ile Asp Ile Arg Ser Ala Phe Lys Arg Ser Gly Glu Gly Gln Glu 
        195                 200                 205             


Asp Ala Gly Glu Leu Asp Phe Ser Gly Leu Leu Lys Arg Arg Glu Val 
    210                 215                 220                 


Lys Gln Gln Glu Glu Glu Pro Gln Val Asp Val Trp Glu Leu Leu Lys 
225                 230                 235                 240 


Asn Ala Lys Pro Ser Glu Tyr Glu Lys Ile Ala Phe Gln Tyr Gly Ile 
                245                 250                 255     


Thr Asp Leu Arg Gly Met Leu Lys Arg Leu Lys Arg Met Arg Arg Glu 
            260                 265                 270         


Glu Lys Lys Ser Ala Ala Phe Ala Lys Ile Leu Asp Pro Ala Tyr Gln 
        275                 280                 285             


Val Asp Lys Gly Gly Arg Val Arg Phe Val Val Glu Leu Ala Asp Pro 
    290                 295                 300                 


Lys Leu Glu Val Lys Trp Tyr Lys Asn Gly Gln Glu Ile Arg Pro Ser 
305                 310                 315                 320 


Thr Lys Tyr Ile Phe Glu His Lys Gly Cys Gln Arg Ile Leu Phe Ile 
                325                 330                 335     


Asn Asn Cys Gln Met Thr Asp Asp Ser Glu Tyr Tyr Val Thr Ala Gly 
            340                 345                 350         


Asp Glu Lys Cys Ser Thr Glu Leu Phe Val Arg Glu Pro Pro Ile Met 
        355                 360                 365             


Val Thr Lys Gln Leu Glu Asp Thr Thr Ala Tyr Cys Gly Glu Arg Val 
    370                 375                 380                 


Glu Leu Glu Cys Glu Val Ser Glu Asp Asp Ala Asn Val Lys Trp Phe 
385                 390                 395                 400 


Lys Asn Gly Glu Glu Ile Ile Pro Gly Pro Lys Ser Arg Tyr Arg Ile 
                405                 410                 415     


Arg Val Glu Gly Lys Lys His Ile Leu Ile Ile Glu Gly Ala Thr Lys 
            420                 425                 430         


Ala Asp Ala Ala Glu Tyr Ser Val Met Thr Thr Gly Gly Gln Ser Ser 
        435                 440                 445             


Ala Lys Leu Ser Val Asp Leu Lys Pro Leu Lys Ile Leu Thr Pro Leu 
    450                 455                 460                 


Thr Asp Gln Thr Val Asn Leu Gly Lys Glu Ile Cys Leu Lys Cys Glu 
465                 470                 475                 480 


Ile Ser Glu Asn Ile Pro Gly Lys Trp Thr Lys Asn Gly Leu Pro Val 
                485                 490                 495     


Gln Glu Ser Asp Arg Leu Lys Val Val His Lys Gly Arg Ile His Lys 
            500                 505                 510         


Leu Val Ile Ala Asn Ala Leu Thr Glu Asp Glu Gly Asp Tyr Val Phe 
        515                 520                 525             


Ala Pro Asp Ala Tyr Asn Val Thr Leu Pro Ala Lys Val His Val Ile 
    530                 535                 540                 


Asp Pro Pro Lys Ile Ile Leu Asp Gly Leu Asp Ala Asp Asn Thr Val 
545                 550                 555                 560 


Thr Val Ile Ala Gly Asn Lys Leu Arg Leu Glu Ile Pro Ile Ser Gly 
                565                 570                 575     


Glu Pro Pro Pro Lys Ala Met Trp Ser Arg Gly Asp Lys Ala Ile Met 
            580                 585                 590         


Glu Gly Ser Gly Arg Ile Arg Thr Glu Ser Tyr Pro Asp Ser Ser Thr 
        595                 600                 605             


Leu Val Ile Asp Ile Ala Glu Arg Asp Asp Ser Gly Val Tyr His Ile 
    610                 615                 620                 


Asn Leu Lys Asn Glu Ala Gly Glu Ala His Ala Ser Ile Lys Val Lys 
625                 630                 635                 640 


Val Val Asp Phe Pro Asp Pro Pro Val Ala Pro Thr Val Thr Glu Val 
                645                 650                 655     


Gly Asp Asp Trp Cys Ile Met Asn Trp Glu Pro Pro Ala Tyr Asp Gly 
            660                 665                 670         


Gly Ser Pro Ile Leu Gly Tyr Phe Ile Glu Arg Lys Lys Lys Gln Ser 
        675                 680                 685             


Ser Arg Trp Met Arg Leu Asn Phe Asp Leu Cys Lys Glu Thr Thr Phe 
    690                 695                 700                 


Glu Pro Lys Lys Met Ile Glu Gly Val Ala Tyr Glu Val Arg Ile Phe 
705                 710                 715                 720 


Ala Val Asn Ala Ile Gly Ile Ser Lys Pro Ser Met Pro Ser Arg Pro 
                725                 730                 735     


Phe Val Pro Leu Ala Val Thr Ser Pro Pro Thr Leu Leu Thr Val Asp 
            740                 745                 750         


Ser Val Thr Asp Thr Thr Val Thr Met Arg Trp Arg Pro Pro Asp His 
        755                 760                 765             


Ile Gly Ala Ala Gly Leu Asp Gly Tyr Val Leu Glu Tyr Cys Phe Glu 
    770                 775                 780                 


Gly Thr Glu Asp Trp Ile Val Ala Asn Lys Asp Leu Ile Asp Lys Thr 
785                 790                 795                 800 


Lys Phe Thr Ile Thr Gly Leu Pro Thr Asp Ala Lys Ile Phe Val Arg 
                805                 810                 815     


Val Lys Ala Val Asn Ala Ala Gly Ala Ser Glu Pro Lys Tyr Tyr Ser 
            820                 825                 830         


Gln Pro Ile Leu Val Lys Glu Ile Ile Glu Pro Pro Lys Ile Arg Ile 
        835                 840                 845             


Pro Arg His Leu Lys Gln Thr Tyr Ile Arg Arg Val Gly Glu Ala Val 
    850                 855                 860                 


Asn Leu Val Ile Pro Phe Gln Gly Lys Pro Arg Pro Glu Leu Thr Trp 
865                 870                 875                 880 


Lys Lys Asp Gly Ala Glu Ile Asp Lys Asn Gln Ile Asn Ile Arg Asn 
                885                 890                 895     


Ser Glu Thr Asp Thr Ile Ile Phe Ile Arg Lys Ala Glu Arg Ser His 
            900                 905                 910         


Ser Gly Lys Tyr Asp Leu Gln Val Lys Val Asp Lys Phe Val Glu Thr 
        915                 920                 925             


Ala Ser Ile Asp Ile Gln Ile Ile Asp Arg Pro Gly Pro Pro Gln Ile 
    930                 935                 940                 


Val Lys Ile Glu Asp Val Trp Gly Glu Asn Val Ala Leu Thr Trp Thr 
945                 950                 955                 960 


Pro Pro Lys Asp Asp Gly Asn Ala Ala Ile Thr Gly Tyr Thr Ile Gln 
                965                 970                 975     


Lys Ala Asp Lys Lys Ser Met Glu Trp Phe Thr Val Ile Glu His Tyr 
            980                 985                 990         


His Arg Thr Ser Ala Thr Ile Thr  Glu Leu Val Ile Gly  Asn Glu Tyr 
        995                 1000                 1005             


Tyr Phe  Arg Val Phe Ser Glu  Asn Met Cys Gly Leu  Ser Glu Asp 
    1010                 1015                 1020             


Ala Thr  Met Thr Lys Glu Ser  Ala Val Ile Ala Arg  Asp Gly Lys 
    1025                 1030                 1035             


Ile Tyr  Lys Asn Pro Val Tyr  Glu Asp Phe Asp Phe  Ser Glu Ala 
    1040                 1045                 1050             


Pro Met  Phe Thr Gln Pro Leu  Val Asn Thr Tyr Ala  Ile Ala Gly 
    1055                 1060                 1065             


Tyr Asn  Ala Thr Leu Asn Cys  Ser Val Arg Gly Asn  Pro Lys Pro 
    1070                 1075                 1080             


Lys Ile  Thr Trp Met Lys Asn  Lys Val Ala Ile Val  Asp Asp Pro 
    1085                 1090                 1095             


Arg Tyr  Arg Met Phe Ser Asn  Gln Gly Val Cys Thr  Leu Glu Ile 
    1100                 1105                 1110             


Arg Lys  Pro Ser Pro Tyr Asp  Gly Gly Thr Tyr Cys  Cys Lys Ala 
    1115                 1120                 1125             


Val Asn  Asp Leu Gly Thr Val  Glu Ile Glu Cys Lys  Leu Glu Val 
    1130                 1135                 1140             


Lys Val  Ile Tyr Gln Gly Val  Asn Thr Pro Gly Gln  Pro Val Phe 
    1145                 1150                 1155             


Leu Glu  Gly Gln Gln Gln Ser  Leu His Asn Lys Asp  Phe 
    1160                 1165                 1170     


<210>  337
<211>  2347
<212>  DNA
<213>  Homo sapiens

<400>  337
attcggagct gcctcctcgc caatgattcc agcgcctgac agccaggacc ccaggcagca     60

gcgagtgaca ggacgtctgg accggcgcgc cgctagcagc tctgccgggc cgcggcggtg    120

atcgatgggg agcggctgga gcggacccag cgagtgaggg cgcacagccg ggacgccgag    180

gcggcgggcg ggagacccgc accagcgcag ccggccctcg gcgggacgtg acgcagcgcc    240

cggggcgcgg gtttgatatt tgacaaattg atctaaaatg gctgggtttt tatctgaata    300

actcactgat gccatcccag aaagtcggca ccaggtgtat ttgatatagt gtttgcaaca    360

aattcgaccc aggtgatcaa aatgattctc aactcttcta ctgaagatgg tattaaaaga    420

atccaagatg attgtcccaa agctggaagg cataattaca tatttgtcat gattcctact    480

ttatacagta tcatctttgt ggtgggaata tttggaaaca gcttggtggt gatagtcatt    540

tacttttata tgaagctgaa gactgtggcc agtgtttttc ttttgaattt agcactggct    600

gacttatgct ttttactgac tttgccacta tgggctgtct acacagctat ggaataccgc    660

tggccctttg gcaattacct atgtaagatt gcttcagcca gcgtcagttt caacctgtac    720

gctagtgtgt ttctactcac gtgtctcagc attgatcgat acctggctat tgttcaccca    780

atgaagtccc gccttcgacg cacaatgctt gtagccaaag tcacctgcat catcatttgg    840

ctgctggcag gcttggccag tttgccagct ataatccatc gaaatgtatt tttcattgag    900

aacaccaata ttacagtttg tgctttccat tatgagtccc aaaattcaac ccttccgata    960

gggctgggcc tgaccaaaaa tatactgggt ttcctgtttc cttttctgat cattcttaca   1020

agttatactc ttatttggaa ggccctaaag aaggcttatg aaattcagaa gaacaaacca   1080

agaaatgatg atatttttaa gataattatg gcaattgtgc ttttcttttt cttttcctgg   1140

attccccacc aaatattcac ttttctggat gtattgattc aactaggcat catacgtgac   1200

tgtagaattg cagatattgt ggacacggcc atgcctatca ccatttgtat agcttatttt   1260

aacaattgcc tgaatcctct tttttatggc tttctgggga aaaaatttaa aagatatttt   1320

ctccagcttc taaaatatat tcccccaaaa gccaaatccc actcaaacct ttcaacaaaa   1380

atgagcacgc tttcctaccg cccctcagat aatgtaagct catccaccaa gaagcctgca   1440

ccatgttttg aggttgagtg acatgttcga aacctgtcca taaagtaatt ttgtgaaaga   1500

aggagcaaga gaacattcct ctgcagcact tcactaccaa atgagcatta gctacttttc   1560

agaattgaag gagaaaatgc attatgtgga ctgaaccgac ttttctaaag ctctgaacaa   1620

aagcttttct ttccttttgc aacaagacaa agcaaagcca cattttgcat tagacagatg   1680

acggctgctc gaagaacaat gtcagaaact cgatgaatgt gttgatttga gaaattttac   1740

tgacagaaat gcaatctccc tagcctgctt ttgtcctgtt attttttatt tccacataaa   1800

ggtatttaga atatattaaa tcgttagagg agcaacagga gatgagagtt ccagattgtt   1860

ctgtccagtt tccaaagggc agtaaagttt tcgtgccggt tttcagctat tagcaactgt   1920

gctacacttg cacctggtac tgcacatttt gtacaaagat atgctaagca gtagtcgtca   1980

agttgcagat ctttttgtga aattcaacct gtgtcttata ggtttacact gccaaaacaa   2040

tgcccgtaag atggcttatt tgtataatgg tgttactaaa gtcacatata aaagttaaac   2100

tacttgtaaa ggtgctgcac tggtcccaag tagtagtgtc ctcctagtat attagtttga   2160

tttaatatct gagaagtgta tatagtttgt ggtaaaaaga ttatatatca taaagtatgc   2220

cttcctgttt aaaaaaagta tatattctac acatatatat atatgtatat ctatatctct   2280

aaactgctgt taattgatta aaatctggca aagttatatt tactttaaaa taaaataatt   2340

ttattgc                                                             2347


<210>  338
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp 
1               5                   10                  15      


Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro 
            20                  25                  30          


Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu 
        35                  40                  45              


Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser 
    50                  55                  60                  


Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr 
65                  70                  75                  80  


Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe 
                85                  90                  95      


Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 
            100                 105                 110         


Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val 
    130                 135                 140                 


Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser 
145                 150                 155                 160 


Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn 
                165                 170                 175     


Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr Leu Pro 
            180                 185                 190         


Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 
        195                 200                 205             


Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys 
    210                 215                 220                 


Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys 
225                 230                 235                 240 


Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His 
                245                 250                 255     


Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg 
            260                 265                 270         


Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile 
        275                 280                 285             


Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe 
    290                 295                 300                 


Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile 
305                 310                 315                 320 


Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr 
                325                 330                 335     


Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro 
            340                 345                 350         


Ala Pro Cys Phe Glu Val Glu 
        355                 


<210>  339
<211>  1920
<212>  DNA
<213>  Homo sapiens

<400>  339
ccacagttcc tttccccgat agcttcaaat tctctgcctt ttgaaataag cctactttta     60

actggaataa ataattggtc aatctctacc tcaggtgaag aggaaccaag cctctggaaa    120

cacttaggaa caaactgtaa aaaccaaagg caattgtgta accggttaaa taagcttgct    180

ggactttgtc cctgtgtatg agttagacaa ttctttcagc tagtttgagt gacgcactga    240

ccagtgaagc gcagtgaagc agtgggaacc ggaatatcca aagagtggtt tgaaggagaa    300

agaagcattg tggctttata tcctctgggc ctgggtttcc tgaagtcacc acacatagag    360

gagagagaaa atggctgagt taaagtacat ttctggattt gggaatgagt gttcttcaga    420

ggatcctcgc tgcccaggtt ccctgccaga aggacagaat aatcctcagg tctgccccta    480

caatctctat gctgagcagc tctcaggatc ggctttcact tgtccacgga gcaccaataa    540

gagaagctgg ctgtatagga ttctaccttc agtttctcac aagccctttg aatccattga    600

cgaaggccaa gtcactcaca actgggatga agttgatcct gatcctaacc agcttagatg    660

gaaaccattt gagattccaa aagcatctca gaagaaagta gactttgtga gtggcctgca    720

taccttgtgt ggagctggag acataaagtc taacaatggg cttgctatcc acattttcct    780

ctgcaatacc tccatggaga acagatgctt ttacaattca gatggggact tcttgattgt    840

tccgcagaaa gggaaccttc tcatttacac cgagtttggc aagatgcttg tacagcccaa    900

tgagatctgc gtcattcaga gaggaatgcg gttcagcata gatgtctttg aggagaccag    960

gggctacatc ttggaggtct atggtgtcca ctttgagtta cctgaccttg gaccaattgg   1020

ggccaatggc ttggccaatc ctcgtgattt cttgataccc attgcctggt atgaggatcg   1080

ccaagtacca ggtggttaca cggtcattaa taaataccag ggcaagctgt ttgctgccaa   1140

acaggatgtc tccccgttca atgttgtggc ctggcacggg aattatacac cctacaagta   1200

caacctgaag aatttcatgg ttatcaactc agtggccttt gaccatgcag acccatccat   1260

tttcacagta ttgactgcta agtctgtccg ccctggagtg gccattgctg attttgtcat   1320

cttcccacct cgatgggggg ttgctgataa gaccttcagg cctccttatt accataggaa   1380

ctgcatgagt gagttcatgg gactcatccg aggtcactat gaggcaaagc aaggtgggtt   1440

cctgccaggg ggagggagtc tacacagcac aatgaccccc catggacctg atgctgactg   1500

ctttgagaag gccagcaagg tcaagctggc acctgagagg attgccgatg gcaccatggc   1560

atttatgttt gaatcatctt taagtctggc ggtcacaaag tggggactca aggcctccag   1620

gtgtttggat gagaactacc acaagtgctg ggagccactc aagagccact tcactcccaa   1680

ctccaggaac ccagcagaac ctaattgaga ctggaacatt gctaccataa ttaagagtag   1740

atttgtgaag atttcttcag aatctcatgc tttctggtag tattggagga gggggttggt   1800

taaaatgaaa attcactttt catagtcaag taactcagaa cttttatgga aacgcatttg   1860

caaagttcta tggctgtcac cttaattact caataaactt gctggtgttc tgtggacgta   1920


<210>  340
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Ala Glu Leu Lys Tyr Ile Ser Gly Phe Gly Asn Glu Cys Ser Ser 
1               5                   10                  15      


Glu Asp Pro Arg Cys Pro Gly Ser Leu Pro Glu Gly Gln Asn Asn Pro 
            20                  25                  30          


Gln Val Cys Pro Tyr Asn Leu Tyr Ala Glu Gln Leu Ser Gly Ser Ala 
        35                  40                  45              


Phe Thr Cys Pro Arg Ser Thr Asn Lys Arg Ser Trp Leu Tyr Arg Ile 
    50                  55                  60                  


Leu Pro Ser Val Ser His Lys Pro Phe Glu Ser Ile Asp Glu Gly His 
65                  70                  75                  80  


Val Thr His Asn Trp Asp Glu Val Asp Pro Asp Pro Asn Gln Leu Arg 
                85                  90                  95      


Trp Lys Pro Phe Glu Ile Pro Lys Ala Ser Gln Lys Lys Val Asp Phe 
            100                 105                 110         


Val Ser Gly Leu His Thr Leu Cys Gly Ala Gly Asp Ile Lys Ser Asn 
        115                 120                 125             


Asn Gly Leu Ala Ile His Ile Phe Leu Cys Asn Thr Ser Met Glu Asn 
    130                 135                 140                 


Arg Cys Phe Tyr Asn Ser Asp Gly Asp Phe Leu Ile Val Pro Gln Lys 
145                 150                 155                 160 


Gly Asn Leu Leu Ile Tyr Thr Glu Phe Gly Lys Met Leu Val Gln Pro 
                165                 170                 175     


Asn Glu Ile Cys Val Ile Gln Arg Gly Met Arg Phe Ser Ile Asp Val 
            180                 185                 190         


Phe Glu Glu Thr Arg Gly Tyr Ile Leu Glu Val Tyr Gly Val His Phe 
        195                 200                 205             


Glu Leu Pro Asp Leu Gly Pro Ile Gly Ala Asn Gly Leu Ala Asn Pro 
    210                 215                 220                 


Arg Asp Phe Leu Ile Pro Ile Ala Trp Tyr Glu Asp Arg Gln Val Pro 
225                 230                 235                 240 


Gly Gly Tyr Thr Val Ile Asn Lys Tyr Gln Gly Lys Leu Phe Ala Ala 
                245                 250                 255     


Lys Gln Asp Val Ser Pro Phe Asn Val Val Ala Trp His Gly Asn Tyr 
            260                 265                 270         


Thr Pro Tyr Lys Tyr Asn Leu Lys Asn Phe Met Val Ile Asn Ser Val 
        275                 280                 285             


Ala Phe Asp His Ala Asp Pro Ser Ile Phe Thr Val Leu Thr Ala Lys 
    290                 295                 300                 


Ser Val Arg Pro Gly Val Ala Ile Ala Asp Phe Val Ile Phe Pro Pro 
305                 310                 315                 320 


Arg Trp Gly Val Ala Asp Lys Thr Phe Arg Pro Pro Tyr Tyr His Arg 
                325                 330                 335     


Asn Cys Met Ser Glu Phe Met Gly Leu Ile Arg Gly His Tyr Glu Ala 
            340                 345                 350         


Lys Gln Gly Gly Phe Leu Pro Gly Gly Gly Ser Leu His Ser Thr Met 
        355                 360                 365             


Thr Pro His Gly Pro Asp Ala Asp Cys Phe Glu Lys Ala Ser Lys Val 
    370                 375                 380                 


Lys Leu Ala Pro Glu Arg Ile Ala Asp Gly Thr Met Ala Phe Met Phe 
385                 390                 395                 400 


Glu Ser Ser Leu Ser Leu Ala Val Thr Lys Trp Gly Leu Lys Ala Ser 
                405                 410                 415     


Arg Cys Leu Asp Glu Asn Tyr His Lys Cys Trp Glu Pro Leu Lys Ser 
            420                 425                 430         


His Phe Thr Pro Asn Ser Arg Asn Pro Ala Glu Pro Asn 
        435                 440                 445 


<210>  341
<211>  3327
<212>  DNA
<213>  Homo sapiens

<400>  341
ggaagaggag gggggagaag gaggagctga agcgggaaga gcggcaggca gcggctcggc     60

ggagttgcag cagaggcggc ggcgacgctg agacaccgca gcttccctga gcgccgagtc    120

cctccgggga cagcagcagg gagcgcccgc gcagccaccg agcctctgcc cagccaagcc    180

gccgtcgccg cgccggggga ccgccagcca tggccgcgcc gggggatccg caggacgagc    240

tgctgccgct ggccggcccc gggtcccagt ggctcaggca ccggggggag ggggagaacg    300

aagcggtgac gccgaaaggg gccacgccgg cgccgcaggc tggggagccc agcccggggt    360

tgggcgccag ggcccgggaa gcggcgtcgc gggaagccgg ctcgggcccc gcccggcagt    420

cgcccgttgc catggaaact gcatccacag gtgtggcagg tgtttccagt gccatggacc    480

acaccttctc aacaacatca aaagatgggg aaggatcgtg ttacacatct ctcatttctg    540

acatctgcta tccacctcag gaggattcta catattttac tggaattctt cagaaggaaa    600

atggccacgt caccatttca gagagccctg aggagctggg tacacccggc ccctccttac    660

cagatgtgcc tgggatagag tctcgtggct tatttagttc tgattctgga atagagatga    720

ctcctgcaga gtccacggaa gtgaacaaga tcttagcaga ccctctggac cagatgaaag    780

cagaggccta taaatacatt gacataacca gacccgagga ggtgaagcac caagaacaac    840

atcaccccga gctggaagat aaagacttgg actttaagaa taaagacact gacatctcaa    900

ttaaacctga aggagtccgt gaacctgaca aaccagctcc tgtggaggga aaaatcatca    960

aggaccattt attggaagaa tccacatttg ctccatacat agatgatctc tctgaagaac   1020

agcgcagggc tcctcagatc accacccctg tcaaaatcac actgacggaa atagaacctt   1080

ctgttgaaac cactacccaa gagaagaccc ctgagaagca agatatatgt ctaaagccaa   1140

gtcctgacac agtccccact gtcactgtct cggagcctga agacgacagc ccaggatcta   1200

tcacccctcc atcttctgga acagaaccat ctgctgcaga atcccagggg aaaggcagca   1260

tctccgagga tgagctgatc accgccatca aagaagcaaa gggattatcg tatgaaaccg   1320

ccgagaaccc acggccggtg ggccagctgg ccgacaggcc cgaggtcaag gccaggtccg   1380

gaccgccaac catccccagc cccctggacc acgaggccag cagcgcggag tcgggggact   1440

cagagatcga gctggtgtcc gaggacccca tggccgcgga ggacgcgctg ccctcaggct   1500

atgtgagctt tggccacgtg ggcggcccgc cgccctcgcc cgcctcgcca tccatccagt   1560

acagcatcct gagggaggag cgcgaggccg agctggacag cgagctcatc atcgagtcgt   1620

gcgacgcctc ctcggcctcg gaggagagcc ccaagcggga gcaggactca cccccgatga   1680

agcccagcgc cctggatgcc atccgggagg agactggcgt ccgggccgag gagcgtgcgc   1740

caagccggcg gggcctggcc gagccgggtt ccttcctcga ctacccctca actgagcccc   1800

agcctggccc cgagctgccc cctggagacg gagccctgga gcctgagacg cccatgttgc   1860

cacggaagcc tgaagaagac tcgagttcca accaaagtcc tgcggccaca aagggccctg   1920

ggcctctagg tcctggcgcc ccgcccccac tgctgtttct caataagcaa aaagctattg   1980

acctgttgta ttggcgggac atcaagcaga cgggcatcgt gtttgggagt ttcctgctgc   2040

tgctcttctc cctgacccag ttcagcgtgg tgagcgtcgt ggcctacctg gccctggccg   2100

cactctcagc caccatcagt ttccgcatct acaagtctgt tttacaagca gtgcagaaaa   2160

ccgacgaagg ccaccctttc aaggcctact tggagcttga gatcaccctt tctcaggagc   2220

agattcagaa gtacacggac tgcctgcagt tctacgtgaa cagcacactt aaggaactga   2280

ggaggctctt ccttgtccag gacctggtgg attccttaaa atttgcagtc ctgatgtggc   2340

tcctgaccta cgttggcgct ctcttcaatg gcctgaccct gctgctcatg gctgtggttt   2400

caatgtttac tctacctgta gtgtatgtta agcaccaggc acagattgac caatatctgg   2460

gacttgtgag gactcacata aatgctgttg tggcaaagat tcaggctaaa atcccaggcg   2520

ctaagaggca cgctgagtaa actgatttcc caccggggac tggacacaaa caggaatgtc   2580

tggagtggta acagctctct tcttactcat tactgcaaat tgattgtctt tcccccctcc   2640

ctccagtacc ataatcttag agacaaacct taaaacagct gtttttaggc tgttccttgt   2700

actcttagga tatttgagtc acttgtgtca accactaaag tatagagaaa agtgtattag   2760

atgtggtttt taattttgtg ttgctaaaaa aagtgcatga tggtgagagc ccaagttatc   2820

tttccctctt cggtgttctt cttctcttct ctgcaatgct tctgtagctt ctaatgttcc   2880

ccgtggctag gcctttcctg ccgagtgctc tgatgcaata gtggaaatcg cttatatgtc   2940

cttgggttgc tggttggatt aatctttaat aacaatatat agaattgtag actgatgttt   3000

tagcattttt ccaacacaca caacgtaaaa ataaaagcag tcgaccgcac ttatggtaat   3060

cagttttgta taacttaaaa taattaaata aatgaataaa tccaaaacaa acatgcagta   3120

cttttgttgt atgggattgg tgggctgatt tacatgtatg gttactaaaa agtaccagca   3180

tgttaacttt attacaattt gtattacttt ctctgtagtt cctaatggat tcaattacgg   3240

actctggata tttgcactta tgtacttgat actgaatgca taaataaatg ttactaaatg   3300

tagaatgtta aaaaaaaaaa aaaaaaa                                       3327


<210>  342
<211>  776
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Ala Ala Pro Gly Asp Pro Gln Asp Glu Leu Leu Pro Leu Ala Gly 
1               5                   10                  15      


Pro Gly Ser Gln Trp Leu Arg His Arg Gly Glu Gly Glu Asn Glu Ala 
            20                  25                  30          


Val Thr Pro Lys Gly Ala Thr Pro Ala Pro Gln Ala Gly Glu Pro Ser 
        35                  40                  45              


Pro Gly Leu Gly Ala Arg Ala Arg Glu Ala Ala Ser Arg Glu Ala Gly 
    50                  55                  60                  


Ser Gly Pro Ala Arg Gln Ser Pro Val Ala Met Glu Thr Ala Ser Thr 
65                  70                  75                  80  


Gly Val Ala Gly Val Ser Ser Ala Met Asp His Thr Phe Ser Thr Thr 
                85                  90                  95      


Ser Lys Asp Gly Glu Gly Ser Cys Tyr Thr Ser Leu Ile Ser Asp Ile 
            100                 105                 110         


Cys Tyr Pro Pro Gln Glu Asp Ser Thr Tyr Phe Thr Gly Ile Leu Gln 
        115                 120                 125             


Lys Glu Asn Gly His Val Thr Ile Ser Glu Ser Pro Glu Glu Leu Gly 
    130                 135                 140                 


Thr Pro Gly Pro Ser Leu Pro Asp Val Pro Gly Ile Glu Ser Arg Gly 
145                 150                 155                 160 


Leu Phe Ser Ser Asp Ser Gly Ile Glu Met Thr Pro Ala Glu Ser Thr 
                165                 170                 175     


Glu Val Asn Lys Ile Leu Ala Asp Pro Leu Asp Gln Met Lys Ala Glu 
            180                 185                 190         


Ala Tyr Lys Tyr Ile Asp Ile Thr Arg Pro Glu Glu Val Lys His Gln 
        195                 200                 205             


Glu Gln His His Pro Glu Leu Glu Asp Lys Asp Leu Asp Phe Lys Asn 
    210                 215                 220                 


Lys Asp Thr Asp Ile Ser Ile Lys Pro Glu Gly Val Arg Glu Pro Asp 
225                 230                 235                 240 


Lys Pro Ala Pro Val Glu Gly Lys Ile Ile Lys Asp His Leu Leu Glu 
                245                 250                 255     


Glu Ser Thr Phe Ala Pro Tyr Ile Asp Asp Leu Ser Glu Glu Gln Arg 
            260                 265                 270         


Arg Ala Pro Gln Ile Thr Thr Pro Val Lys Ile Thr Leu Thr Glu Ile 
        275                 280                 285             


Glu Pro Ser Val Glu Thr Thr Thr Gln Glu Lys Thr Pro Glu Lys Gln 
    290                 295                 300                 


Asp Ile Cys Leu Lys Pro Ser Pro Asp Thr Val Pro Thr Val Thr Val 
305                 310                 315                 320 


Ser Glu Pro Glu Asp Asp Ser Pro Gly Ser Ile Thr Pro Pro Ser Ser 
                325                 330                 335     


Gly Thr Glu Pro Ser Ala Ala Glu Ser Gln Gly Lys Gly Ser Ile Ser 
            340                 345                 350         


Glu Asp Glu Leu Ile Thr Ala Ile Lys Glu Ala Lys Gly Leu Ser Tyr 
        355                 360                 365             


Glu Thr Ala Glu Asn Pro Arg Pro Val Gly Gln Leu Ala Asp Arg Pro 
    370                 375                 380                 


Glu Val Lys Ala Arg Ser Gly Pro Pro Thr Ile Pro Ser Pro Leu Asp 
385                 390                 395                 400 


His Glu Ala Ser Ser Ala Glu Ser Gly Asp Ser Glu Ile Glu Leu Val 
                405                 410                 415     


Ser Glu Asp Pro Met Ala Ala Glu Asp Ala Leu Pro Ser Gly Tyr Val 
            420                 425                 430         


Ser Phe Gly His Val Gly Gly Pro Pro Pro Ser Pro Ala Ser Pro Ser 
        435                 440                 445             


Ile Gln Tyr Ser Ile Leu Arg Glu Glu Arg Glu Ala Glu Leu Asp Ser 
    450                 455                 460                 


Glu Leu Ile Ile Glu Ser Cys Asp Ala Ser Ser Ala Ser Glu Glu Ser 
465                 470                 475                 480 


Pro Lys Arg Glu Gln Asp Ser Pro Pro Met Lys Pro Ser Ala Leu Asp 
                485                 490                 495     


Ala Ile Arg Glu Glu Thr Gly Val Arg Ala Glu Glu Arg Ala Pro Ser 
            500                 505                 510         


Arg Arg Gly Leu Ala Glu Pro Gly Ser Phe Leu Asp Tyr Pro Ser Thr 
        515                 520                 525             


Glu Pro Gln Pro Gly Pro Glu Leu Pro Pro Gly Asp Gly Ala Leu Glu 
    530                 535                 540                 


Pro Glu Thr Pro Met Leu Pro Arg Lys Pro Glu Glu Asp Ser Ser Ser 
545                 550                 555                 560 


Asn Gln Ser Pro Ala Ala Thr Lys Gly Pro Gly Pro Leu Gly Pro Gly 
                565                 570                 575     


Ala Pro Pro Pro Leu Leu Phe Leu Asn Lys Gln Lys Ala Ile Asp Leu 
            580                 585                 590         


Leu Tyr Trp Arg Asp Ile Lys Gln Thr Gly Ile Val Phe Gly Ser Phe 
        595                 600                 605             


Leu Leu Leu Leu Phe Ser Leu Thr Gln Phe Ser Val Val Ser Val Val 
    610                 615                 620                 


Ala Tyr Leu Ala Leu Ala Ala Leu Ser Ala Thr Ile Ser Phe Arg Ile 
625                 630                 635                 640 


Tyr Lys Ser Val Leu Gln Ala Val Gln Lys Thr Asp Glu Gly His Pro 
                645                 650                 655     


Phe Lys Ala Tyr Leu Glu Leu Glu Ile Thr Leu Ser Gln Glu Gln Ile 
            660                 665                 670         


Gln Lys Tyr Thr Asp Cys Leu Gln Phe Tyr Val Asn Ser Thr Leu Lys 
        675                 680                 685             


Glu Leu Arg Arg Leu Phe Leu Val Gln Asp Leu Val Asp Ser Leu Lys 
    690                 695                 700                 


Phe Ala Val Leu Met Trp Leu Leu Thr Tyr Val Gly Ala Leu Phe Asn 
705                 710                 715                 720 


Gly Leu Thr Leu Leu Leu Met Ala Val Val Ser Met Phe Thr Leu Pro 
                725                 730                 735     


Val Val Tyr Val Lys His Gln Ala Gln Ile Asp Gln Tyr Leu Gly Leu 
            740                 745                 750         


Val Arg Thr His Ile Asn Ala Val Val Ala Lys Ile Gln Ala Lys Ile 
        755                 760                 765             


Pro Gly Ala Lys Arg His Ala Glu 
    770                 775     


<210>  343
<211>  5899
<212>  DNA
<213>  Homo sapiens

<400>  343
tattgcacta catcactgag ttcccgtatg ccaagttatg gccacttaca tccacgtcag     60

caaaactggt gccgagggag ctgttcttga cgaagctaaa aatatcaata agtctttgtc    120

tgctcttgga aatgtgatct ctgctttggc agaagggaca aaaacacatg tgccataccg    180

ggacagcaag atgactcgga ttcttcagga ctctttgggt gggaactgca gaaccaccat    240

cgtcatttgc tgttctcctt ctgtcttcaa tgaggctgag accaagtcca cactgatgtt    300

cggacagaga gctaagacca tcaagaatac agtctctgtg aacctagaac tgacagcaga    360

agaatggaag aagaaatatg aaaaagagaa agagaaaaac aagactttga agaatgttat    420

ccagcatctg gagatggagc taaacaggtg gaggaatgga gaagctgtgc ctgaggatga    480

acagatcagt gccaaggacc agaagaacct ggagccttgt gataacaccc ccatcataga    540

caatattgct cctgttgttg ctggcatctc tacagaggag aaagagaagt acgatgagga    600

gatctccagt ctctacagac aactggatga caaggatgat gaaattaacc agcagagcca    660

gctggctgaa aagctgaagc aacagatgtt ggatcaggat gagcttttag cttccacaag    720

aagagactat gagaagatac aggaggagct gacacgtctc cagattgaaa atgaggcagc    780

caaggatgag gtgaaagaag ttctccaggc cctggaggag ctggctgtca attatgacca    840

gaaatcacag gaagtggagg ataagacccg ggccaatgag cagctgacag acgagctggc    900

ccagaaaacg actacattga caaccacaca gagagagctg agccagctac aagagcttag    960

caaccaccag aagaaaaggg caactgagat cctgaatttg ctgttgaaag atctggggga   1020

gataggtgga attattggca ccaatgatgt gaaaactttg gcagatgtga atggagtcat   1080

tgaggaggag tttaccatgg cccgcctgta catcagcaag atgaagtcag aggtcaagtc   1140

cctggtgaac cgcagcaaac agctcgagag cgcccagatg gactccaaca ggaagatgaa   1200

tgccagcgag cgggagctgg cagcctgcca gctgctcatc tcccagcacg aagccaagat   1260

caagtctctg acagactaca tgcagaacat ggaacagaag aggaggcagc tagaagagtc   1320

ccaggactcg ctcagcgaag agctggcaaa gctccgagcc caggaaaaaa tgcacgaagt   1380

cagcttccag gataaggaga aggaacatct gacgcggttg caggatgctg aagaaatgaa   1440

gaaggcgctg gagcagcaga tggagagcca ccgggaagct caccagaagc agctgtccag   1500

actccgagac gaaattgagg agaagcagaa aatcattgat gagattcggg atttgaatca   1560

gaaactgcaa ctggaacagg agaagcttag ttctgattat aacaagctga aaatagagga   1620

ccaagagaga gaaatgaagc tggaaaagct cttattgctc aacgataaaa gggaacaagc   1680

cagagaagac ctcaaagggc tggaggagac agtgtctaga gaattgcaga cactgcacaa   1740

ccttcggaaa ctctttgtcc aggatctgac cacccgagtt aaaaaaagtg tggagttgga   1800

caacgatgat ggagggggca gtgctgccca gaagcagaaa atttccttct tggagaataa   1860

cctggagcag ctcaccaaag ttcacaagca gctggtccgg gacaacgcag acctgcgctg   1920

tgaactgccc aagctggaga agcggctgcg tgccacggcg gagcgcgtca aggctctgga   1980

gagcgcgctg aaggaggcca aggagaacgc catgcgggac cgtaagcgct accagcagga   2040

ggtggatcgt atcaaggagg ccgtgcgggc caagaacatg gccagaaggg cccattcagc   2100

ccagatcgcc aagcccatcc gccccggaca ctacccggcc tcatctccaa cggccgtcca   2160

tgccattcga gggggaggag gcagctcttc aaattccact cactaccaga aataaataca   2220

aaatatgact ccacgtagca tgtcaaggac tacattaatc accaattcct ttatttttcc   2280

ccccctacag tttccatttt ttttttatac ttgcttactc cagccatctg cagtacacca   2340

gtttcaggtc ttttgagctg tgtagagttt ctgtgtgtac agatgtgtgc tcggactttt   2400

ctctttttga gaaatctgaa ggagatggtt gcagaagatc cacttactac tgagaaccat   2460

taccaccgac tcggcctccg gggtgttggg tggtttctgg gtggttcctg gagcctcctc   2520

tgggcagtgc actgtcccat ctgtacgccc taatgtgcca ttccctagag gggaacaacc   2580

aagtgccgtg gaggcagatg atcatggtct gcctcaactg tctggtttcc tgtaaaataa   2640

acacattgtt ttatattttt agggaacaaa aagtgctgct atagggttca aagttttcct   2700

tctgaacact tttccgaaac aaattacccc aaagacacat tttgaatatc ctggtcacat   2760

ctttggatct gtaaaatata ccttttagta tggcacctgt taaaatgcaa agcaaatttc   2820

tttggggcag aaaaacaatc tgacagtagc agtgtagaat ttgttcattc aaatacatct   2880

gtgtaaatgc aaaaagtcat aaaattcacc tccgagctgc ttgcttttga acctgcagca   2940

actagtctta gccggcccgg tttgaacatc gttctttcag aagtgctgaa aatgctgcaa   3000

agttggataa gtggaaatgt ggctgcccct ctcctcacta cttcctctct gatcgttctg   3060

aagcttgcat tgggaatggc tgctttctct aaccattttc agcttgagtg ggtattgctg   3120

aagaaatcca acatcattcc agcagttgaa aaaggaagcc ttcgggagaa agtgcttgtc   3180

aaaattttgt tctttgtgct tgtgtatgag taagttgcca tgaataagtt attattttaa   3240

cccataattg gcgactgttt atatgaattc tttctttggc accaaatagg tttcatcttc   3300

ttaggcacaa ttagaaaaaa tccacataga tggatatttt acatttagtt attgctttat   3360

ccaaatacat gaatctaaag ctgaatcaac ccttacttcc agttgtgctt attaagaaga   3420

tcaatttcca agtagtaaag ttttcaggga aactgactgt gctgctattt gttttgacaa   3480

atttgggggt aagtcaatga caaccaaacc aatctcggtg gaaactccta tcctatcatg   3540

ttgtgtgccc aagatgagtg agctggcact gtgccctgaa gctttcacca ctgtaatgaa   3600

atatatgcca ggggagactt tgggcttttc tcatgactgt gtgggtcgaa ggtagctcaa   3660

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtatgt gtgtaaagtg   3720

ctaagaactg tgcattgaca tccaaacatt tcttgtacaa aatttcccta gcaaagcaaa   3780

cctgctttga cttaatttat ttgttaaatg ttgcactttg tttatgtatg ttttgttttt   3840

ggtggggaat aaggagagag aggacgacaa attctattga agtatttatt ttgtgaagat   3900

ggcaattttg catttgttta aatttttttc attctttaat tttgttatca gtgccagccc   3960

aatatacctg ctctaccatt atttgcggtc tgataaaagg gtccttgtgg ggcaggtttt   4020

gcaaagctta tcaggtaata acatatgcca cataaccttg ttgatatgtt tgcttctgat   4080

ttgggaagct aaacattggt gtttgagagg attgccaatt attaattgtc attaccacta   4140

ctctccatta ctttttgttt ggaaattgaa caaaggtcag taatggtttt tggctcttgt   4200

taatatccat cataaaatag attgttttag attctttcca gggtgatttt tccctgggta   4260

ccccgtttct acttctaaag aattgcttgg cactttcatg tttcaaaggg aaacattcgc   4320

ttgtagttcc attttacttg atctctacaa gggactgaca acatttgctt tacttttatt   4380

cacagagaaa gttggctttg atgtctctta aagataattc tgctagttgc tgatcagcca   4440

gtcagttcac ctagcttcaa tctttatagg acttctaatc taattttcct atagtgtgac   4500

taaaagggag gcaaattatt ggaacggatt attcaaatgg atccttaaat attgctatgt   4560

ataataagcc agttattata tcaggaccat gttctctgta ggccactttc taaaaaagcc   4620

acatatgtgc aattttcagg tttttagact attgctccct gtactttaaa tgtaaaaacc   4680

acacttctga acaactaagc tcatgaatat gattttggtt atatgcagct tttgactagc   4740

atgtattgtg tctttttctc ctctatgaat aattttatat ttcatgctac ttcttgaaag   4800

tttactcttt gatgctctaa gagaacagcc agatggttta tatgaataat ctttatctgc   4860

aggatggtgg attggtaaat taggagaatg ttgtttgaga tatcaagatt tatgtctggg   4920

aactaaaata tataatgcca aatgtgtttt tgtcaattac tagagaattc tgtgcaaaca   4980

tatcatctct tcaaatgctg cacactttgc ttttgttaaa cagcaggtag tagacagaac   5040

aataacagtt tcgcgttaag acttttaaag gaaatagaat cgtgattaag aaatcagaat   5100

ttatagatat attgggataa atgaagaaat aaaaatgttt gtctagaatg tagcatctag   5160

tgacttttta aagccctaac gtttacataa agaagctcta gttcttatag aaataacaaa   5220

gcaaataaaa gttcttaaca atcccctctt tcgaagtgca tttttttaaa gcagggcagg   5280

agacatttgg actctagcta tatgacatac tgggaaaggc agagggtgga gggaagattt   5340

cacttcattg tctagcccag aatcttgagc aagctaaaga aaccatcata atctaaaatt   5400

gcttcattta acactaacaa tttagacttt ttaaaccaag cattgaataa tggctggata   5460

actgccgaag taagcgccgc tccatgaagt ctgcttactt atttaaaaat tgtgtatcag   5520

ttttaaatac tgttcattgt gtgcagatat aaggggaata gggcattctg tagaattata   5580

catgtctagt ttgtaaagtg tgtcctgtgt actgcagatg tgtgttctct gggctttatg   5640

tatctgtaca gtagctttca cattaaaaaa attgtggaca aacttgtccg gggggtttga   5700

ggggagaatg gtggtttata tcaataacga tgctgtacta tagtccatgt aacaaaagat   5760

ctggaagtca ccctcctctg gcccacggaa aattttggta atcttctagg ttctaaaatg   5820

aagatgtatg ggtactctgg cagactgcat gttgtataat ttgaaaaata ctaaaagtgg   5880

aaaataaaat tgaattaaa                                                5899


<210>  344
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Ala Thr Tyr Ile His Val Ser Lys Thr Gly Ala Glu Gly Ala Val 
1               5                   10                  15      


Leu Asp Glu Ala Lys Asn Ile Asn Lys Ser Leu Ser Ala Leu Gly Asn 
            20                  25                  30          


Val Ile Ser Ala Leu Ala Glu Gly Thr Lys Thr His Val Pro Tyr Arg 
        35                  40                  45              


Asp Ser Lys Met Thr Arg Ile Leu Gln Asp Ser Leu Gly Gly Asn Cys 
    50                  55                  60                  


Arg Thr Thr Ile Val Ile Cys Cys Ser Pro Ser Val Phe Asn Glu Ala 
65                  70                  75                  80  


Glu Thr Lys Ser Thr Leu Met Phe Gly Gln Arg Ala Lys Thr Ile Lys 
                85                  90                  95      


Asn Thr Val Ser Val Asn Leu Glu Leu Thr Ala Glu Glu Trp Lys Lys 
            100                 105                 110         


Lys Tyr Glu Lys Glu Lys Glu Lys Asn Lys Thr Leu Lys Asn Val Ile 
        115                 120                 125             


Gln His Leu Glu Met Glu Leu Asn Arg Trp Arg Asn Gly Glu Ala Val 
    130                 135                 140                 


Pro Glu Asp Glu Gln Ile Ser Ala Lys Asp Gln Lys Asn Leu Glu Pro 
145                 150                 155                 160 


Cys Asp Asn Thr Pro Ile Ile Asp Asn Ile Ala Pro Val Val Ala Gly 
                165                 170                 175     


Ile Ser Thr Glu Glu Lys Glu Lys Tyr Asp Glu Glu Ile Ser Ser Leu 
            180                 185                 190         


Tyr Arg Gln Leu Asp Asp Lys Asp Asp Glu Ile Asn Gln Gln Ser Gln 
        195                 200                 205             


Leu Ala Glu Lys Leu Lys Gln Gln Met Leu Asp Gln Asp Glu Leu Leu 
    210                 215                 220                 


Ala Ser Thr Arg Arg Asp Tyr Glu Lys Ile Gln Glu Glu Leu Thr Arg 
225                 230                 235                 240 


Leu Gln Ile Glu Asn Glu Ala Ala Lys Asp Glu Val Lys Glu Val Leu 
                245                 250                 255     


Gln Ala Leu Glu Glu Leu Ala Val Asn Tyr Asp Gln Lys Ser Gln Glu 
            260                 265                 270         


Val Glu Asp Lys Thr Arg Ala Asn Glu Gln Leu Thr Asp Glu Leu Ala 
        275                 280                 285             


Gln Lys Thr Thr Thr Leu Thr Thr Thr Gln Arg Glu Leu Ser Gln Leu 
    290                 295                 300                 


Gln Glu Leu Ser Asn His Gln Lys Lys Arg Ala Thr Glu Ile Leu Asn 
305                 310                 315                 320 


Leu Leu Leu Lys Asp Leu Gly Glu Ile Gly Gly Ile Ile Gly Thr Asn 
                325                 330                 335     


Asp Val Lys Thr Leu Ala Asp Val Asn Gly Val Ile Glu Glu Glu Phe 
            340                 345                 350         


Thr Met Ala Arg Leu Tyr Ile Ser Lys Met Lys Ser Glu Val Lys Ser 
        355                 360                 365             


Leu Val Asn Arg Ser Lys Gln Leu Glu Ser Ala Gln Met Asp Ser Asn 
    370                 375                 380                 


Arg Lys Met Asn Ala Ser Glu Arg Glu Leu Ala Ala Cys Gln Leu Leu 
385                 390                 395                 400 


Ile Ser Gln His Glu Ala Lys Ile Lys Ser Leu Thr Asp Tyr Met Gln 
                405                 410                 415     


Asn Met Glu Gln Lys Arg Arg Gln Leu Glu Glu Ser Gln Asp Ser Leu 
            420                 425                 430         


Ser Glu Glu Leu Ala Lys Leu Arg Ala Gln Glu Lys Met His Glu Val 
        435                 440                 445             


Ser Phe Gln Asp Lys Glu Lys Glu His Leu Thr Arg Leu Gln Asp Ala 
    450                 455                 460                 


Glu Glu Met Lys Lys Ala Leu Glu Gln Gln Met Glu Ser His Arg Glu 
465                 470                 475                 480 


Ala His Gln Lys Gln Leu Ser Arg Leu Arg Asp Glu Ile Glu Glu Lys 
                485                 490                 495     


Gln Lys Ile Ile Asp Glu Ile Arg Asp Leu Asn Gln Lys Leu Gln Leu 
            500                 505                 510         


Glu Gln Glu Lys Leu Ser Ser Asp Tyr Asn Lys Leu Lys Ile Glu Asp 
        515                 520                 525             


Gln Glu Arg Glu Met Lys Leu Glu Lys Leu Leu Leu Leu Asn Asp Lys 
    530                 535                 540                 


Arg Glu Gln Ala Arg Glu Asp Leu Lys Gly Leu Glu Glu Thr Val Ser 
545                 550                 555                 560 


Arg Glu Leu Gln Thr Leu His Asn Leu Arg Lys Leu Phe Val Gln Asp 
                565                 570                 575     


Leu Thr Thr Arg Val Lys Lys Ser Val Glu Leu Asp Asn Asp Asp Gly 
            580                 585                 590         


Gly Gly Ser Ala Ala Gln Lys Gln Lys Ile Ser Phe Leu Glu Asn Asn 
        595                 600                 605             


Leu Glu Gln Leu Thr Lys Val His Lys Gln Leu Val Arg Asp Asn Ala 
    610                 615                 620                 


Asp Leu Arg Cys Glu Leu Pro Lys Leu Glu Lys Arg Leu Arg Ala Thr 
625                 630                 635                 640 


Ala Glu Arg Val Lys Ala Leu Glu Ser Ala Leu Lys Glu Ala Lys Glu 
                645                 650                 655     


Asn Ala Met Arg Asp Arg Lys Arg Tyr Gln Gln Glu Val Asp Arg Ile 
            660                 665                 670         


Lys Glu Ala Val Arg Ala Lys Asn Met Ala Arg Arg Ala His Ser Ala 
        675                 680                 685             


Gln Ile Ala Lys Pro Ile Arg Pro Gly His Tyr Pro Ala Ser Ser Pro 
    690                 695                 700                 


Thr Ala Val His Ala Ile Arg Gly Gly Gly Gly Ser Ser Ser Asn Ser 
705                 710                 715                 720 


Thr His Tyr Gln Lys 
                725 


<210>  345
<211>  5821
<212>  DNA
<213>  Homo sapiens

<400>  345
gctttgccca gtagttggaa agtgaactcg actcgtgatg gttctcctgt cactttggtt     60

gatagcagcc gctctggtag aggttaggac ttcagctgat ggacaagctg gtaatgaaga    120

aatggtgcaa atagatttac caataaagag atatagagag tatgagctgg tgactccagt    180

cagcacaaat ctagaaggac gctatctctc ccatactctt tctgcgagtc acaaaaagag    240

gtcagcgagg gacgtgtctt ccaaccctga gcagttgttc tttaacatca cggcatttgg    300

aaaagatttt catctgcgac taaagcccaa cactcaacta gtagctcctg gggctgttgt    360

ggagtggcat gagacatctc tggtgcctgg gaatataacc gatcccatta acaaccatca    420

accaggaagt gctacgtata gaatccggaa aacagagcct ttgcagacta actgtgctta    480

tgttggtgac atcgtggaca ttccaggaac ctctgttgcc atcagcaact gtgatggtct    540

ggctggaatg ataaaaagtg ataatgaaga gtatttcatt gaacccttgg aaagaggtaa    600

acagatggag gaagaaaaag gaaggattca tgttgtctac aagagatcag ctgtagaaca    660

ggctcccata gacatgtcca aagacttcca ctacagagag tcggacctgg aaggccttga    720

tgatctaggt actgtttatg gcaacatcca ccagcagctg aatgaaacaa tgagacgccg    780

cagacacgcg ggagaaaacg attacaatat cgaggtactg ctgggagtgg atgactctgt    840

ggtccgtttc catggcaaag agcacgtcca aaactacctc ctgaccctaa tgaacattgt    900

gaatgaaatt taccatgatg agtccctcgg agtgcatata aatgtggtcc tggtgcgcat    960

gataatgctg ggatatgcaa agtccatcag cctcatagaa aggggaaacc catccagaag   1020

cttggagaat gtgtgtcgct gggcgtccca acagcaaaga tctgatctca accactctga   1080

acaccatgac catgcaattt ttttaaccag gcaagacttt ggacctgctg gaatgcaagg   1140

atatgctcca gtcaccggca tgtgtcatcc agtgagaagt tgtaccctga atcatgagga   1200

tggtttttca tctgcttttg tagtagccca tgaaacgggc catgtgttgg gaatggagca   1260

tgatggacaa ggcaacaggt gtggtgatga gactgctatg ggaagtgtca tggctccctt   1320

ggtacaagca gcattccatc gttaccactg gtcccgatgc agtggtcaag aactgaaaag   1380

atatatccat tcctatgact gtctccttga tgaccctttt gatcatgatt ggcctaaact   1440

cccagaactt cctggaatca attattctat ggatgagcaa tgtcgttttg attttggtgt   1500

tggctataaa atgtgcaccg cgttccgaac ctttgaccca tgtaaacagc tgtggtgtag   1560

ccatcctgat aatccctact tttgtaagac taaaaaggga cctccacttg atgggactga   1620

atgtgctgct ggaaaatggt gctataaggg tcattgcatg tggaagaatg ctaatcagca   1680

aaaacaagat ggcaattggg ggtcatggac taaatttggc tcctgttctc ggacatgtgg   1740

aactggtgtt cgtttcagaa cacgccagtg caataatccc atgcccatca atggtggtca   1800

ggattgtcct ggtgttaatt ttgagtacca gctttgtaac acagaagaat gccaaaaaca   1860

ctttgaggac ttcagagcac agcagtgtca gcagcgaaac tcccactttg aataccagaa   1920

taccaaacac cactggttgc catatgaaca tcctgacccc aagaaaagat gccaccttta   1980

ctgtcagtcc aaggagactg gagatgttgc ttacatgaaa caactggtgc atgatggaac   2040

gcactgttct tacaaagatc catatagcat atgtgtgcga ggagagtgtg tgaaagtggg   2100

ctgtgataaa gaaattggtt ctaataaggt tgaggataag tgtggtgtct gtggaggaga   2160

taattcccac tgccgaaccg tgaaggggac atttaccaga actcccagga agcttgggta   2220

ccttaagatg tttgatatac cccctggggc tagacatgtg ttaatccaag aagacgaggc   2280

ttctcctcat attcttgcta ttaagaacca ggctacaggc cattatattt taaatggcaa   2340

aggggaggaa gccaagtcgc ggaccttcat agatcttggt gtggagtggg attataacat   2400

tgaagatgac attgaaagtc ttcacaccga tggaccttta catgatcctg ttattgtttt   2460

gattatacct caagaaaatg atacccgctc tagcctgaca tataagtaca tcatccatga   2520

agactctgta cctacaatca acagcaacaa tgtcatccag gaagaattag atacttttga   2580

gtgggctttg aagagctggt ctcagtgttc caaaccctgt ggtggaggtt tccagtacac   2640

taaatatgga tgccgtagga aaagtgataa taaaatggtc catcgcagct tctgtgaggc   2700

caacaaaaag ccgaaaccta ttagacgaat gtgcaatatt caagagtgta cacatccact   2760

ctgggtagca gaagaatggg aacactgcac caaaacctgt ggaagttctg gctatcagct   2820

tcgcactgta cgctgccttc agccactcct tgatggcacc aaccgctctg tgcacagcaa   2880

atactgcatg ggtgaccgtc ccgagagccg ccggccctgt aacagagtgc cctgccctgc   2940

acagtggaaa acaggaccct ggagtgagtg ttcagtgacc tgcggtgaag gaacggaggt   3000

gaggcaggtc ctctgcaggg ctggggacca ctgtgatggt gaaaagcctg agtcggtcag   3060

agcctgtcaa ctgcctcctt gtaatgatga accatgtttg ggagacaagt ccatattctg   3120

tcaaatggaa gtgttggcac gatactgctc cataccaggt tataacaagt tatgttgtga   3180

gtcctgcagc aagcgcagta gcaccctgcc accaccatac cttctagaag ctgctgaaac   3240

tcatgatgat gtcatctcta accctagtga cctccctaga tctctagtga tgcctacatc   3300

tttggttcct tatcattcag agacccctgc aaagaagatg tctttgagta gcatctcttc   3360

agtgggaggt ccaaatgcat atgctgcttt caggccaaac agtaaacctg atggtgctaa   3420

tttacgccag aggagtgctc agcaagcagg aagtaagact gtgagactgg tcaccgtacc   3480

atcctcccca cccaccaaga gggtccacct cagttcagct tcacaaatgg ctgctgcttc   3540

cttctttgca gccagtgatt caataggtgc ttcttctcag gcaagaacct caaagaaaga   3600

tggaaagatc attgacaaca gacgtccgac aagatcatcc accttagaaa gatgagaaag   3660

tgaaccaaaa aggctagaaa ccagaggaaa acctggacaa cctctctctt cccatggtgc   3720

atatgcttgt ttaaagtgga aatctctata gatcgtcagc tcattttatc tgtaattgga   3780

agaacagaaa gtgctggctc actttctagt tgctttcatc ctccttttgt tctgcattga   3840

ctcatttacc agaattcatt ggaagaaatc accaaagatt attacaaaag aaaaatatgt   3900

tgctaagatt gtgttggtcg ctctctgaag cagaaaaggg actggaacca attgtgcata   3960

tcagctgact ttttgtttgt tttagaaaag ttacagtaaa aattaaaaag agataccaat   4020

ggtttacact ttaacaagaa attttggata tggaacaaag aattcttaga cttgtattcc   4080

tatttatcta tattagaaat attgtatgag caaatttgca gctgttgtgt aaatactgta   4140

tattgcaaaa atcagtatta ttttaagaga tgtgttctca aatgattgtt tactatatta   4200

catttctgga tgttctaggt gcctgtcgtt gagtattgcc ttgtttgaca ttctataggt   4260

taattttcaa agcagagtat tacaaaagag aagttagaat tacagctact gacaatataa   4320

agggttttgt tgaatcaaca atgtgatacg taaattatag aaaaagaaaa gaaacacaaa   4380

agctatagat atacagatat cagcttacct attgccttct atacttataa tttaaaggat   4440

tggtgtctta gtacacttgt ggtcacaggg atcaacgaat agtaaataat gaactcgtgc   4500

aagacaaaac tgaaaccctc tttccaggac ctcagtaggc accgttgagg tgtcctttgt   4560

ttttgtgtgt gtgtgttctt ttttaatttt cgcattgttg acagatacaa acagttatac   4620

tcaatgtact gtaataatcg caaaggaaaa agttttggga taacttattt gtatgttggt   4680

agctgagaaa aatatcatca gtctagaatt gatatttgag tatagtagag ctttggggct   4740

ttgaaggcag gttcaagaaa gcatatgtcg atggttgaga tatttatttt ccatatggtt   4800

catgttcaaa tgttcacaac cacaatgcat ctgactgcaa taatgtgcta ataatttatg   4860

tcagtagtca ccttgctcac agcaaagcca gaaatgctct ctccagggag tagatgtaaa   4920

gtacttgtac atagaattca gaactgaaga tatttattaa aagttgattt tttttcttga   4980

tagtattttt atgtactaaa tatttacact aatatcaatt acatattttg gtaaactaga   5040

gagacataat tagagatgca tgctttgttc tgtgcataga gacctttaag caaactacta   5100

cagccaactc aaaagctaaa actgaacaaa tttgatgtta tgcaaacatc ttgcattttt   5160

agtagttgat attaagttga tgacttgttt cccttcaagg aaacattaaa ttgtatggac   5220

tcagctagct gttcaatgaa attgtgaatt agaaacattt ttaaaagttt ttgaaagaga   5280

taagtgcatc atgaattaca tgtacatgag aggagatagt gatatcagca taatgatttt   5340

gaggtcagta cctgagctgt ctaaaaatat attatacaaa ctaaaatgta gatgaattaa   5400

cctctcaaag cacagaatgt gcaagaactt ttgcatttta atcgttgtaa actaacagct   5460

taaactattg actctatacc tctaaagaat tgctgctact ttgtgcaaga actttgaagg   5520

tcaaattagg caaattccag atagtaaaac aatccctaag ccttaagtct tttttttttc   5580

ctaaaaattc ccatagaata aaattctctc tagtttactt gtgtgtgcat acatctcatc   5640

cacaggggaa gataaagatg gtcacacaaa cagtttccat aaagatgtac atattcatta   5700

tacttctgac ctttgggctt tcttttctac taagctaaaa attccttttt atcaaagtgt   5760

acactactga tgctgtttgt tgtactgaga gcacgtacca ataaaaatgt taacaaaata   5820

t                                                                   5821


<210>  346
<211>  1205
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Val Leu Leu Ser Leu Trp Leu Ile Ala Ala Ala Leu Val Glu Val 
1               5                   10                  15      


Arg Thr Ser Ala Asp Gly Gln Ala Gly Asn Glu Glu Met Val Gln Ile 
            20                  25                  30          


Asp Leu Pro Ile Lys Arg Tyr Arg Glu Tyr Glu Leu Val Thr Pro Val 
        35                  40                  45              


Ser Thr Asn Leu Glu Gly Arg Tyr Leu Ser His Thr Leu Ser Ala Ser 
    50                  55                  60                  


His Lys Lys Arg Ser Ala Arg Asp Val Ser Ser Asn Pro Glu Gln Leu 
65                  70                  75                  80  


Phe Phe Asn Ile Thr Ala Phe Gly Lys Asp Phe His Leu Arg Leu Lys 
                85                  90                  95      


Pro Asn Thr Gln Leu Val Ala Pro Gly Ala Val Val Glu Trp His Glu 
            100                 105                 110         


Thr Ser Leu Val Pro Gly Asn Ile Thr Asp Pro Ile Asn Asn His Gln 
        115                 120                 125             


Pro Gly Ser Ala Thr Tyr Arg Ile Arg Lys Thr Glu Pro Leu Gln Thr 
    130                 135                 140                 


Asn Cys Ala Tyr Val Gly Asp Ile Val Asp Ile Pro Gly Thr Ser Val 
145                 150                 155                 160 


Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly Met Ile Lys Ser Asp Asn 
                165                 170                 175     


Glu Glu Tyr Phe Ile Glu Pro Leu Glu Arg Gly Lys Gln Met Glu Glu 
            180                 185                 190         


Glu Lys Gly Arg Ile His Val Val Tyr Lys Arg Ser Ala Val Glu Gln 
        195                 200                 205             


Ala Pro Ile Asp Met Ser Lys Asp Phe His Tyr Arg Glu Ser Asp Leu 
    210                 215                 220                 


Glu Gly Leu Asp Asp Leu Gly Thr Val Tyr Gly Asn Ile His Gln Gln 
225                 230                 235                 240 


Leu Asn Glu Thr Met Arg Arg Arg Arg His Ala Gly Glu Asn Asp Tyr 
                245                 250                 255     


Asn Ile Glu Val Leu Leu Gly Val Asp Asp Ser Val Val Arg Phe His 
            260                 265                 270         


Gly Lys Glu His Val Gln Asn Tyr Leu Leu Thr Leu Met Asn Ile Val 
        275                 280                 285             


Asn Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile Asn Val Val 
    290                 295                 300                 


Leu Val Arg Met Ile Met Leu Gly Tyr Ala Lys Ser Ile Ser Leu Ile 
305                 310                 315                 320 


Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Asn Val Cys Arg Trp Ala 
                325                 330                 335     


Ser Gln Gln Gln Arg Ser Asp Leu Asn His Ser Glu His His Asp His 
            340                 345                 350         


Ala Ile Phe Leu Thr Arg Gln Asp Phe Gly Pro Ala Gly Met Gln Gly 
        355                 360                 365             


Tyr Ala Pro Val Thr Gly Met Cys His Pro Val Arg Ser Cys Thr Leu 
    370                 375                 380                 


Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Val Ala His Glu Thr 
385                 390                 395                 400 


Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn Arg Cys Gly 
                405                 410                 415     


Asp Glu Thr Ala Met Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala 
            420                 425                 430         


Phe His Arg Tyr His Trp Ser Arg Cys Ser Gly Gln Glu Leu Lys Arg 
        435                 440                 445             


Tyr Ile His Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp His Asp 
    450                 455                 460                 


Trp Pro Lys Leu Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu 
465                 470                 475                 480 


Gln Cys Arg Phe Asp Phe Gly Val Gly Tyr Lys Met Cys Thr Ala Phe 
                485                 490                 495     


Arg Thr Phe Asp Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn 
            500                 505                 510         


Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Glu 
        515                 520                 525             


Cys Ala Ala Gly Lys Trp Cys Tyr Lys Gly His Cys Met Trp Lys Asn 
    530                 535                 540                 


Ala Asn Gln Gln Lys Gln Asp Gly Asn Trp Gly Ser Trp Thr Lys Phe 
545                 550                 555                 560 


Gly Ser Cys Ser Arg Thr Cys Gly Thr Gly Val Arg Phe Arg Thr Arg 
                565                 570                 575     


Gln Cys Asn Asn Pro Met Pro Ile Asn Gly Gly Gln Asp Cys Pro Gly 
            580                 585                 590         


Val Asn Phe Glu Tyr Gln Leu Cys Asn Thr Glu Glu Cys Gln Lys His 
        595                 600                 605             


Phe Glu Asp Phe Arg Ala Gln Gln Cys Gln Gln Arg Asn Ser His Phe 
    610                 615                 620                 


Glu Tyr Gln Asn Thr Lys His His Trp Leu Pro Tyr Glu His Pro Asp 
625                 630                 635                 640 


Pro Lys Lys Arg Cys His Leu Tyr Cys Gln Ser Lys Glu Thr Gly Asp 
                645                 650                 655     


Val Ala Tyr Met Lys Gln Leu Val His Asp Gly Thr His Cys Ser Tyr 
            660                 665                 670         


Lys Asp Pro Tyr Ser Ile Cys Val Arg Gly Glu Cys Val Lys Val Gly 
        675                 680                 685             


Cys Asp Lys Glu Ile Gly Ser Asn Lys Val Glu Asp Lys Cys Gly Val 
    690                 695                 700                 


Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys Gly Thr Phe Thr 
705                 710                 715                 720 


Arg Thr Pro Arg Lys Leu Gly Tyr Leu Lys Met Phe Asp Ile Pro Pro 
                725                 730                 735     


Gly Ala Arg His Val Leu Ile Gln Glu Asp Glu Ala Ser Pro His Ile 
            740                 745                 750         


Leu Ala Ile Lys Asn Gln Ala Thr Gly His Tyr Ile Leu Asn Gly Lys 
        755                 760                 765             


Gly Glu Glu Ala Lys Ser Arg Thr Phe Ile Asp Leu Gly Val Glu Trp 
    770                 775                 780                 


Asp Tyr Asn Ile Glu Asp Asp Ile Glu Ser Leu His Thr Asp Gly Pro 
785                 790                 795                 800 


Leu His Asp Pro Val Ile Val Leu Ile Ile Pro Gln Glu Asn Asp Thr 
                805                 810                 815     


Arg Ser Ser Leu Thr Tyr Lys Tyr Ile Ile His Glu Asp Ser Val Pro 
            820                 825                 830         


Thr Ile Asn Ser Asn Asn Val Ile Gln Glu Glu Leu Asp Thr Phe Glu 
        835                 840                 845             


Trp Ala Leu Lys Ser Trp Ser Gln Cys Ser Lys Pro Cys Gly Gly Gly 
    850                 855                 860                 


Phe Gln Tyr Thr Lys Tyr Gly Cys Arg Arg Lys Ser Asp Asn Lys Met 
865                 870                 875                 880 


Val His Arg Ser Phe Cys Glu Ala Asn Lys Lys Pro Lys Pro Ile Arg 
                885                 890                 895     


Arg Met Cys Asn Ile Gln Glu Cys Thr His Pro Leu Trp Val Ala Glu 
            900                 905                 910         


Glu Trp Glu His Cys Thr Lys Thr Cys Gly Ser Ser Gly Tyr Gln Leu 
        915                 920                 925             


Arg Thr Val Arg Cys Leu Gln Pro Leu Leu Asp Gly Thr Asn Arg Ser 
    930                 935                 940                 


Val His Ser Lys Tyr Cys Met Gly Asp Arg Pro Glu Ser Arg Arg Pro 
945                 950                 955                 960 


Cys Asn Arg Val Pro Cys Pro Ala Gln Trp Lys Thr Gly Pro Trp Ser 
                965                 970                 975     


Glu Cys Ser Val Thr Cys Gly Glu Gly Thr Glu Val Arg Gln Val Leu 
            980                 985                 990         


Cys Arg Ala Gly Asp His Cys Asp  Gly Glu Lys Pro Glu  Ser Val Arg 
        995                 1000                 1005             


Ala Cys  Gln Leu Pro Pro Cys  Asn Asp Glu Pro Cys  Leu Gly Asp 
    1010                 1015                 1020             


Lys Ser  Ile Phe Cys Gln Met  Glu Val Leu Ala Arg  Tyr Cys Ser 
    1025                 1030                 1035             


Ile Pro  Gly Tyr Asn Lys Leu  Cys Cys Glu Ser Cys  Ser Lys Arg 
    1040                 1045                 1050             


Ser Ser  Thr Leu Pro Pro Pro  Tyr Leu Leu Glu Ala  Ala Glu Thr 
    1055                 1060                 1065             


His Asp  Asp Val Ile Ser Asn  Pro Ser Asp Leu Pro  Arg Ser Leu 
    1070                 1075                 1080             


Val Met  Pro Thr Ser Leu Val  Pro Tyr His Ser Glu  Thr Pro Ala 
    1085                 1090                 1095             


Lys Lys  Met Ser Leu Ser Ser  Ile Ser Ser Val Gly  Gly Pro Asn 
    1100                 1105                 1110             


Ala Tyr  Ala Ala Phe Arg Pro  Asn Ser Lys Pro Asp  Gly Ala Asn 
    1115                 1120                 1125             


Leu Arg  Gln Arg Ser Ala Gln  Gln Ala Gly Ser Lys  Thr Val Arg 
    1130                 1135                 1140             


Leu Val  Thr Val Pro Ser Ser  Pro Pro Thr Lys Arg  Val His Leu 
    1145                 1150                 1155             


Ser Ser  Ala Ser Gln Met Ala  Ala Ala Ser Phe Phe  Ala Ala Ser 
    1160                 1165                 1170             


Asp Ser  Ile Gly Ala Ser Ser  Gln Ala Arg Thr Ser  Lys Lys Asp 
    1175                 1180                 1185             


Gly Lys  Ile Ile Asp Asn Arg  Arg Pro Thr Arg Ser  Ser Thr Leu 
    1190                 1195                 1200             


Glu Arg  
    1205 


<210>  347
<211>  9179
<212>  DNA
<213>  Homo sapiens

<400>  347
gcaagaactg caggggagga ggacgctgcc acccacagcc tctagagctc attgcagctg     60

ggacagcccg gagtgtggtt agcagctcgg caagcgctgc ccaggtcctg gggtggtggc    120

agccagcggg agcaggaaag gaagcatgtt cccaggctgc ccacgcctct gggtcctggt    180

ggtcttgggc accagctggg taggctgggg gagccaaggg acagaagcgg cacagctaag    240

gcagttctac gtggctgctc agggcatcag ttggagctac cgacctgagc ccacaaactc    300

aagtttgaat ctttctgtaa cttcctttaa gaaaattgtc tacagagagt atgaaccata    360

ttttaagaaa gaaaaaccac aatctaccat ttcaggactt cttgggccta ctttatatgc    420

tgaagtcgga gacatcataa aagttcactt taaaaataag gcagataagc ccttgagcat    480

ccatcctcaa ggaattaggt acagtaaatt atcagaaggt gcttcttacc ttgaccacac    540

attccctgcg gagaagatgg acgacgctgt ggctccaggc cgagaataca cctatgaatg    600

gagtatcagt gaggacagtg gacccaccca tgatgaccct ccatgcctca cacacatcta    660

ttactcccat gaaaatctga tcgaggattt caactcgggg ctgattgggc ccctgcttat    720

ctgtaaaaaa gggaccctaa ctgagggtgg gacacagaag acgtttgaca agcaaatcgt    780

gctactattt gctgtgtttg atgaaagcaa gagctggagc cagtcatcat ccctaatgta    840

cacagtcaat ggatatgtga atgggacaat gccagatata acagtttgtg cccatgacca    900

catcagctgg catctgctgg gaatgagctc ggggccagaa ttattctcca ttcatttcaa    960

cggccaggtc ctggagcaga accatcataa ggtctcagcc atcacccttg tcagtgctac   1020

atccactacc gcaaatatga ctgtgggccc agagggaaag tggatcatat cttctctcac   1080

cccaaaacat ttgcaagctg ggatgcaggc ttacattgac attaaaaact gcccaaagaa   1140

aaccaggaat cttaagaaaa taactcgtga gcagaggcgg cacatgaaga ggtgggaata   1200

cttcattgct gcagaggaag tcatttggga ctatgcacct gtaataccag cgaatatgga   1260

caaaaaatac aggtctcagc atttggataa tttctcaaac caaattggaa aacattataa   1320

gaaagttatg tacacacagt acgaagatga gtccttcacc aaacatacag tgaatcccaa   1380

tatgaaagaa gatgggattt tgggtcctat tatcagagcc caggtcagag acacactcaa   1440

aatcgtgttc aaaaatatgg ccagccgccc ctatagcatt taccctcatg gagtgacctt   1500

ctcgccttat gaagatgaag tcaactcttc tttcacctca ggcaggaaca acaccatgat   1560

cagagcagtt caaccagggg aaacctatac ttataagtgg aacatcttag agtttgatga   1620

acccacagaa aatgatgccc agtgcttaac aagaccatac tacagtgacg tggacatcat   1680

gagagacatc gcctctgggc taataggact acttctaatc tgtaagagca gatccctgga   1740

caggcgagga atacagaggg cagcagacat cgaacagcag gctgtgtttg ctgtgtttga   1800

tgagaacaaa agctggtacc ttgaggacaa catcaacaag ttttgtgaaa atcctgatga   1860

ggtgaaacgt gatgacccca agttttatga atcaaacatc atgagcacta tcaatggcta   1920

tgtgcctgag agcataacta ctcttggatt ctgctttgat gacactgtcc agtggcactt   1980

ctgtagtgtg gggacccaga atgaaatttt gaccatccac ttcactgggc actcattcat   2040

ctatggaaag aggcatgagg acaccttgac cctcttcccc atgcgtggag aatctgtgac   2100

ggtcacaatg gataatgttg gaacttggat gttaacttcc atgaattcta gtccaagaag   2160

caaaaagctg aggctgaaat tcagggatgt taaatgtatc ccagatgatg atgaagactc   2220

atatgagatt tttgaacctc cagaatctac agtcatggct acacggaaaa tgcatgatcg   2280

tttagaacct gaagatgaag agagtgatgc tgactatgat taccagaaca gactggctgc   2340

agcattagga atcaggtcat tccgaaactc atcattgaat caggaagaag aagagttcaa   2400

tcttactgcc ctagctctgg agaatggcac tgaattcgtt tcttcaaaca cagatataat   2460

tgttggttca aattattctt ccccaagtaa tattagtaag ttcactgtca ataaccttgc   2520

agaacctcag aaagcccctt ctcaccaaca agccaccaca gctggttccc cactgagaca   2580

cctcattggc aagaactcag ttctcaattc ttccacagca gagcattcca gcccatattc   2640

tgaagaccct atagaggatc ctctacagcc agatgtcaca gggatacgtc tactttcact   2700

tggtgctgga gaattcaaaa gtcaagaaca tgctaagcat aagggaccca aggtagaaag   2760

agatcaagca gcaaagcaca ggttctcctg gatgaaatta ctagcacata aagttgggag   2820

acacctaagc caagacactg gttctccttc cggaatgagg ccctgggagg accttcctag   2880

ccaagacact ggttctcctt ccagaatgag gccctggaag gaccctccta gtgatctgtt   2940

actcttaaaa caaagtaact catctaagat tttggttggg agatggcatt tggcttctga   3000

gaaaggtagc tatgaaataa tccaagatac tgatgaagac acagctgtta acaattggct   3060

gatcagcccc cagaatgcct cacgtgcttg gggagaaagc acccctcttg ccaacaagcc   3120

tggaaagcag agtggccacc caaagtttcc tagagttaga cataaatctc tacaagtaag   3180

acaggatgga ggaaagagta gactgaagaa aagccagttt ctcattaaga cacgaaaaaa   3240

gaaaaaagag aagcacacac accatgctcc tttatctccg aggacctttc accctctaag   3300

aagtgaagcc tacaacacat tttcagaaag aagacttaag cattcgttgg tgcttcataa   3360

atccaatgaa acatctcttc ccacagacct caatcagaca ttgccctcta tggattttgg   3420

ctggatagcc tcacttcctg accataatca gaattcctca aatgacactg gtcaggcaag   3480

ctgtcctcca ggtctttatc agacagtgcc cccagaggaa cactatcaaa cattccccat   3540

tcaagaccct gatcaaatgc actctacttc agaccccagt cacagatcct cttctccaga   3600

gctcagtgaa atgcttgagt atgaccgaag tcacaagtcc ttccccacag atataagtca   3660

aatgtcccct tcctcagaac atgaagtctg gcagacagtc atctctccag acctcagcca   3720

ggtgaccctc tctccagaac tcagccagac aaacctctct ccagacctca gccacacgac   3780

tctctctcca gaactcattc agagaaacct ttccccagcc ctcggtcaga tgcccatttc   3840

tccagacctc agccatacaa ccctttctcc agacctcagc catacaaccc tttctttaga   3900

cctcagccag acaaacctct ctccagaact cagtcagaca aacctttctc cagccctcgg   3960

tcagatgccc ctttctccag acctcagcca tacaaccctt tctctagact tcagccagac   4020

aaacctctct ccagaactca gccatatgac tctctctcca gaactcagtc agacaaacct   4080

ttccccagcc ctcggtcaga tgcccatttc tccagacctc agccatacaa ccctttctct   4140

agacttcagc cagacaaacc tctctccaga actcagtcaa acaaaccttt ccccagccct   4200

cggtcagatg cccctttctc cagaccccag ccatacaacc ctttctctag acctcagcca   4260

gacaaacctc tctccagaac tcagtcagac aaacctttcc ccagacctca gtgagatgcc   4320

cctctttgca gatctcagtc aaattcccct taccccagac ctcgaccaga tgacactttc   4380

tccagacctt ggtgagacag atctttcccc aaactttggt cagatgtccc tttccccaga   4440

cctcagccag gtgactctct ctccagacat cagtgacacc acccttctcc cggatctcag   4500

ccagatatca cctcctccag accttgatca gatattctac ccttctgaat ctagtcagtc   4560

attgcttctt caagaattta atgagtcttt tccttatcca gaccttggtc agatgccatc   4620

tccttcatct cctactctca atgatacttt tctatcaaag gaatttaatc cactggttat   4680

agtgggcctc agtaaagatg gtacagatta cattgagatc attccaaagg aagaggtcca   4740

gagcagtgaa gatgactatg ctgaaattga ttatgtgccc tatgatgacc cctacaaaac   4800

tgatgttagg acaaacatca actcctccag agatcctgac aacattgcag catggtacct   4860

ccgcagcaac aatggaaaca gaagaaatta ttacattgct gctgaagaaa tatcctggga   4920

ttattcagaa tttgtacaaa gggaaacaga tattgaagac tctgatgata ttccagaaga   4980

taccacatat aagaaagtag tttttcgaaa gtacctcgac agcactttta ccaaacgtga   5040

tcctcgaggg gagtatgaag agcatctcgg aattcttggt cctattatca gagctgaagt   5100

ggatgatgtt atccaagttc gttttaaaaa tttagcatcc agaccgtatt ctctacatgc   5160

ccatggactt tcctatgaaa aatcatcaga gggaaagact tatgaagatg actctcctga   5220

atggtttaag gaagataatg ctgttcagcc aaatagcagt tatacctacg tatggcatgc   5280

cactgagcga tcagggccag aaagtcctgg ctctgcctgt cgggcttggg cctactactc   5340

agctgtgaac ccagaaaaag atattcactc aggcttgata ggtcccctcc taatctgcca   5400

aaaaggaata ctacataagg acagcaacat gcctatggac atgagagaat ttgtcttact   5460

atttatgacc tttgatgaaa agaagagctg gtactatgaa aagaagtccc gaagttcttg   5520

gagactcaca tcctcagaaa tgaaaaaatc ccatgagttt cacgccatta atgggatgat   5580

ctacagcttg cctggcctga aaatgtatga gcaagagtgg gtgaggttac acctgctgaa   5640

cataggcggc tcccaagaca ttcacgtggt tcactttcac ggccagacct tgctggaaaa   5700

tggcaataaa cagcaccagt taggggtctg gccccttctg cctggttcat ttaaaactct   5760

tgaaatgaag gcatcaaaac ctggctggtg gctcctaaac acagaggttg gagaaaacca   5820

gagagcaggg atgcaaacgc catttcttat catggacaga gactgtagga tgccaatggg   5880

actaagcact ggtatcatat ctgattcaca gatcaaggct tcagagtttc tgggttactg   5940

ggagcccaga ttagcaagat taaacaatgg tggatcttat aatgcttgga gtgtagaaaa   6000

acttgcagca gaatttgcct ctaaaccttg gatccaggtg gacatgcaaa aggaagtcat   6060

aatcacaggg atccagaccc aaggtgccaa acactacctg aagtcctgct ataccacaga   6120

gttctatgta gcttacagtt ccaaccagat caactggcag atcttcaaag ggaacagcac   6180

aaggaatgtg atgtatttta atggcaattc agatgcctct acaataaaag agaatcagtt   6240

tgacccacct attgtggcta gatatattag gatctctcca actcgagcct ataacagacc   6300

tacccttcga ttggaactgc aaggttgtga ggtaaatgga tgttccacac ccctgggtat   6360

ggaaaatgga aagatagaaa acaagcaaat cacagcttct tcgtttaaga aatcttggtg   6420

gggagattac tgggaaccct tccgtgcccg tctgaatgcc cagggacgtg tgaatgcctg   6480

gcaagccaag gcaaacaaca ataagcagtg gctagaaatt gatctactca agatcaagaa   6540

gataacggca attataacac agggctgcaa gtctctgtcc tctgaaatgt atgtaaagag   6600

ctataccatc cactacagtg agcagggagt ggaatggaaa ccatacaggc tgaaatcctc   6660

catggtggac aagatttttg aaggaaatac taataccaaa ggacatgtga agaacttttt   6720

caacccccca atcatttcca ggtttatccg tgtcattcct aaaacatgga atcaaagtat   6780

tgcacttcgc ctggaactct ttggctgtga tatttactag aattgaacat tcaaaaaccc   6840

ctggaagaga ctctttaaga cctcaaacca tttagaatgg gcaatgtatt ttacgctgtg   6900

ttaaatgtta acagttttcc actatttctc tttcttttct attagtgaat aaaattttat   6960

acaagaagct tttataatgt aactccttgc taccagtaag taagataatg gctattactt   7020

ctgcattaat ttgaatacag gtaggaaaat atcaagaacc aacaagaaaa gggcttatct   7080

ttcttaatga ttgaaaatgc tatgaagtaa tatttatgta gttaaaatgc ttcattataa   7140

ctcttttaaa tcctttacac actagtaaaa cagatattac tttaaataat aattgataga   7200

cctggataac tttcacaaac acatgatttt ttaatggttt ttcttgagtg aagagaaaaa   7260

caatattatc aaatgaaata agtacttaaa atatcctgtc tttcccatat aacaatgatt   7320

tttctgactt tccatgagta aaaaaacagc caagcatctt tccagtagcc ccattgaaat   7380

tgtgaatccg tcctggtctc cctaaggact gcacacattg atattcaagg ttggtggtca   7440

ttagatatgg aacagaactg aaataaccat ggtagaactg aatgtgtaat gttggcttta   7500

ttctagctgg tactacatgg cacacagttt caaaacataa tttcacctac tggaaagctc   7560

agacctgtaa aacagagcat gggaactgct ggtctaaatg cagttgttcc tgctcaaaga   7620

gacctctggc caaactggca agcagttaaa gttttctttc agggccttcc tctctatggc   7680

ctcaacttcc tcctctctct tcttccagca acttcccctt tcatcattcc tttccctggg   7740

gacttggcat tcagtgatcc tgtagatatt gcacaactgg ggaaccttta gacatcctta   7800

aaatcacatg agatagacag tcatttgggg tgtctgaaat aaaccacccc aaaacttagt   7860

gttaaaagag caaccaaaaa aaatttatgt gagattatgg atttgttact tagcttgatt   7920

taatcatcct gtaacgtgta catatatcaa aatgttatgt ataccataaa tatataaaat   7980

tttatcaacg aaattcataa caatctctca gaccacagag aaatcaaatt agaactgagg   8040

actaagaaac tcactcgaaa ccacacaact acatggaaac tgaacaacct gctcctgaat   8100

gactactggg taaataatga aattaaggca gaaataaata agttccttaa aaccaatgag   8160

aacaaagaga caacatacca gaatctctag gagacagggc tttgcttttg ctgcattcta   8220

ttcgttgtga acacaaatta caggccagtc tcgattcagt gtagaaggga actgcataag   8280

gaccacatac caggaggcat aattcactgg gagcatcttt agaaactacc agagttacct   8340

gttgcccata ccagtggggt aagccctatg aatgtatatg agagtttcaa acatccacaa   8400

aacattggct ttctaatatt cgtattccca ctattccttt cttttcatga ttcatgtcat   8460

tgtcccatca acatttctaa gatttccatt ccgttaagag caaaagagaa tgttggaagg   8520

tgggggaaaa catttctttg ttttctacag ggccagcttc ttggatgtgt gtgatctgtt   8580

cagttgcaaa gggtcacatg ctcagaagga ccgcatgcta aatttaatgc tttgcagtta   8640

ccctcttgaa atcctttatt ttttaagaag gaattcgaca tttccatttt tcaatgagcc   8700

ccacaaatta cgcagctagt cctgggcttc tctactctga aattgggcag gatctctctt   8760

gatctagaat ttactaaggc ataatagggg caagaaaatc ttatgaaata atggggggta   8820

gggaagagat gggaatggag catgagatcc agcttcgtta ttctctactt gagaaaaata   8880

aggccccaaa gattaaacaa cttgcccaag gatattgctt gttagtgtca gaactgaaac   8940

cagaaaccaa atgatcatat ccctagactt ttagtctgct ttctcttcca taaaatgaaa   9000

cttataatgt ttctaatcca ttgctcagac aggtagacat gaatattaat tgataatgac   9060

tattaattga tctggaaaat acttgtttgg ggatcaataa tatgtttggg ctattatcta   9120

atgctgtgta gaaatattaa aacccctgtt attttgaaat aaaaaagata cccactttt    9179


<210>  348
<211>  2224
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Phe Pro Gly Cys Pro Arg Leu Trp Val Leu Val Val Leu Gly Thr 
1               5                   10                  15      


Ser Trp Val Gly Trp Gly Ser Gln Gly Thr Glu Ala Ala Gln Leu Arg 
            20                  25                  30          


Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser Tyr Arg Pro Glu 
        35                  40                  45              


Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser Phe Lys Lys Ile 
    50                  55                  60                  


Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu Lys Pro Gln Ser 
65                  70                  75                  80  


Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala Glu Val Gly Asp 
                85                  90                  95      


Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys Pro Leu Ser Ile 
            100                 105                 110         


His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu Gly Ala Ser Tyr 
        115                 120                 125             


Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp Ala Val Ala Pro 
    130                 135                 140                 


Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu Asp Ser Gly Pro 
145                 150                 155                 160 


Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr Tyr Ser His Glu 
                165                 170                 175     


Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly Pro Leu Leu Ile 
            180                 185                 190         


Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln Lys Thr Phe Asp 
        195                 200                 205             


Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu Ser Lys Ser Trp 
    210                 215                 220                 


Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly Tyr Val Asn Gly 
225                 230                 235                 240 


Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His Ile Ser Trp His 
                245                 250                 255     


Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser Ile His Phe Asn 
            260                 265                 270         


Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser Ala Ile Thr Leu 
        275                 280                 285             


Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val Gly Pro Glu Gly 
    290                 295                 300                 


Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu Gln Ala Gly Met 
305                 310                 315                 320 


Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys Thr Arg Asn Leu 
                325                 330                 335     


Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys Arg Trp Glu Tyr 
            340                 345                 350         


Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala Pro Val Ile Pro 
        355                 360                 365             


Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu Asp Asn Phe Ser 
    370                 375                 380                 


Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr Thr Gln Tyr Glu 
385                 390                 395                 400 


Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn Met Lys Glu Asp 
                405                 410                 415     


Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg Asp Thr Leu Lys 
            420                 425                 430         


Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser Ile Tyr Pro His 
        435                 440                 445             


Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn Ser Ser Phe Thr 
    450                 455                 460                 


Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln Pro Gly Glu Thr 
465                 470                 475                 480 


Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu Pro Thr Glu Asn 
                485                 490                 495     


Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp Val Asp Ile Met 
            500                 505                 510         


Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu Ile Cys Lys Ser 
        515                 520                 525             


Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala Asp Ile Glu Gln 
    530                 535                 540                 


Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu 
545                 550                 555                 560 


Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu Val Lys Arg Asp 
                565                 570                 575     


Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Thr Ile Asn Gly Tyr 
            580                 585                 590         


Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys Phe Asp Asp Thr Val 
        595                 600                 605             


Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn Glu Ile Leu Thr Ile 
    610                 615                 620                 


His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys Arg His Glu Asp Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val Thr Val Thr Met Asp 
                645                 650                 655     


Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn Ser Ser Pro Arg Ser 
            660                 665                 670         


Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys Cys Ile Pro Asp Asp 
        675                 680                 685             


Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro Glu Ser Thr Val Met 
    690                 695                 700                 


Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro Glu Asp Glu Glu Ser 
705                 710                 715                 720 


Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala Ala Ala Leu Gly Ile 
                725                 730                 735     


Arg Ser Phe Arg Asn Ser Ser Leu Asn Gln Glu Glu Glu Glu Phe Asn 
            740                 745                 750         


Leu Thr Ala Leu Ala Leu Glu Asn Gly Thr Glu Phe Val Ser Ser Asn 
        755                 760                 765             


Thr Asp Ile Ile Val Gly Ser Asn Tyr Ser Ser Pro Ser Asn Ile Ser 
    770                 775                 780                 


Lys Phe Thr Val Asn Asn Leu Ala Glu Pro Gln Lys Ala Pro Ser His 
785                 790                 795                 800 


Gln Gln Ala Thr Thr Ala Gly Ser Pro Leu Arg His Leu Ile Gly Lys 
                805                 810                 815     


Asn Ser Val Leu Asn Ser Ser Thr Ala Glu His Ser Ser Pro Tyr Ser 
            820                 825                 830         


Glu Asp Pro Ile Glu Asp Pro Leu Gln Pro Asp Val Thr Gly Ile Arg 
        835                 840                 845             


Leu Leu Ser Leu Gly Ala Gly Glu Phe Lys Ser Gln Glu His Ala Lys 
    850                 855                 860                 


His Lys Gly Pro Lys Val Glu Arg Asp Gln Ala Ala Lys His Arg Phe 
865                 870                 875                 880 


Ser Trp Met Lys Leu Leu Ala His Lys Val Gly Arg His Leu Ser Gln 
                885                 890                 895     


Asp Thr Gly Ser Pro Ser Gly Met Arg Pro Trp Glu Asp Leu Pro Ser 
            900                 905                 910         


Gln Asp Thr Gly Ser Pro Ser Arg Met Arg Pro Trp Lys Asp Pro Pro 
        915                 920                 925             


Ser Asp Leu Leu Leu Leu Lys Gln Ser Asn Ser Ser Lys Ile Leu Val 
    930                 935                 940                 


Gly Arg Trp His Leu Ala Ser Glu Lys Gly Ser Tyr Glu Ile Ile Gln 
945                 950                 955                 960 


Asp Thr Asp Glu Asp Thr Ala Val Asn Asn Trp Leu Ile Ser Pro Gln 
                965                 970                 975     


Asn Ala Ser Arg Ala Trp Gly Glu Ser Thr Pro Leu Ala Asn Lys Pro 
            980                 985                 990         


Gly Lys Gln Ser Gly His Pro Lys  Phe Pro Arg Val Arg  His Lys Ser 
        995                 1000                 1005             


Leu Gln  Val Arg Gln Asp Gly  Gly Lys Ser Arg Leu  Lys Lys Ser 
    1010                 1015                 1020             


Gln Phe  Leu Ile Lys Thr Arg  Lys Lys Lys Lys Glu  Lys His Thr 
    1025                 1030                 1035             


His His  Ala Pro Leu Ser Pro  Arg Thr Phe His Pro  Leu Arg Ser 
    1040                 1045                 1050             


Glu Ala  Tyr Asn Thr Phe Ser  Glu Arg Arg Leu Lys  His Ser Leu 
    1055                 1060                 1065             


Val Leu  His Lys Ser Asn Glu  Thr Ser Leu Pro Thr  Asp Leu Asn 
    1070                 1075                 1080             


Gln Thr  Leu Pro Ser Met Asp  Phe Gly Trp Ile Ala  Ser Leu Pro 
    1085                 1090                 1095             


Asp His  Asn Gln Asn Ser Ser  Asn Asp Thr Gly Gln  Ala Ser Cys 
    1100                 1105                 1110             


Pro Pro  Gly Leu Tyr Gln Thr  Val Pro Pro Glu Glu  His Tyr Gln 
    1115                 1120                 1125             


Thr Phe  Pro Ile Gln Asp Pro  Asp Gln Met His Ser  Thr Ser Asp 
    1130                 1135                 1140             


Pro Ser  His Arg Ser Ser Ser  Pro Glu Leu Ser Glu  Met Leu Glu 
    1145                 1150                 1155             


Tyr Asp  Arg Ser His Lys Ser  Phe Pro Thr Asp Ile  Ser Gln Met 
    1160                 1165                 1170             


Ser Pro  Ser Ser Glu His Glu  Val Trp Gln Thr Val  Ile Ser Pro 
    1175                 1180                 1185             


Asp Leu  Ser Gln Val Thr Leu  Ser Pro Glu Leu Ser  Gln Thr Asn 
    1190                 1195                 1200             


Leu Ser  Pro Asp Leu Ser His  Thr Thr Leu Ser Pro  Glu Leu Ile 
    1205                 1210                 1215             


Gln Arg  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Ile Ser Pro 
    1220                 1225                 1230             


Asp Leu  Ser His Thr Thr Leu  Ser Pro Asp Leu Ser  His Thr Thr 
    1235                 1240                 1245             


Leu Ser  Leu Asp Leu Ser Gln  Thr Asn Leu Ser Pro  Glu Leu Ser 
    1250                 1255                 1260             


Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Leu Ser Pro 
    1265                 1270                 1275             


Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp Phe Ser  Gln Thr Asn 
    1280                 1285                 1290             


Leu Ser  Pro Glu Leu Ser His  Met Thr Leu Ser Pro  Glu Leu Ser 
    1295                 1300                 1305             


Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Ile Ser Pro 
    1310                 1315                 1320             


Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp Phe Ser  Gln Thr Asn 
    1325                 1330                 1335             


Leu Ser  Pro Glu Leu Ser Gln  Thr Asn Leu Ser Pro  Ala Leu Gly 
    1340                 1345                 1350             


Gln Met  Pro Leu Ser Pro Asp  Pro Ser His Thr Thr  Leu Ser Leu 
    1355                 1360                 1365             


Asp Leu  Ser Gln Thr Asn Leu  Ser Pro Glu Leu Ser  Gln Thr Asn 
    1370                 1375                 1380             


Leu Ser  Pro Asp Leu Ser Glu  Met Pro Leu Phe Ala  Asp Leu Ser 
    1385                 1390                 1395             


Gln Ile  Pro Leu Thr Pro Asp  Leu Asp Gln Met Thr  Leu Ser Pro 
    1400                 1405                 1410             


Asp Leu  Gly Glu Thr Asp Leu  Ser Pro Asn Phe Gly  Gln Met Ser 
    1415                 1420                 1425             


Leu Ser  Pro Asp Leu Ser Gln  Val Thr Leu Ser Pro  Asp Ile Ser 
    1430                 1435                 1440             


Asp Thr  Thr Leu Leu Pro Asp  Leu Ser Gln Ile Ser  Pro Pro Pro 
    1445                 1450                 1455             


Asp Leu  Asp Gln Ile Phe Tyr  Pro Ser Glu Ser Ser  Gln Ser Leu 
    1460                 1465                 1470             


Leu Leu  Gln Glu Phe Asn Glu  Ser Phe Pro Tyr Pro  Asp Leu Gly 
    1475                 1480                 1485             


Gln Met  Pro Ser Pro Ser Ser  Pro Thr Leu Asn Asp  Thr Phe Leu 
    1490                 1495                 1500             


Ser Lys  Glu Phe Asn Pro Leu  Val Ile Val Gly Leu  Ser Lys Asp 
    1505                 1510                 1515             


Gly Thr  Asp Tyr Ile Glu Ile  Ile Pro Lys Glu Glu  Val Gln Ser 
    1520                 1525                 1530             


Ser Glu  Asp Asp Tyr Ala Glu  Ile Asp Tyr Val Pro  Tyr Asp Asp 
    1535                 1540                 1545             


Pro Tyr  Lys Thr Asp Val Arg  Thr Asn Ile Asn Ser  Ser Arg Asp 
    1550                 1555                 1560             


Pro Asp  Asn Ile Ala Ala Trp  Tyr Leu Arg Ser Asn  Asn Gly Asn 
    1565                 1570                 1575             


Arg Arg  Asn Tyr Tyr Ile Ala  Ala Glu Glu Ile Ser  Trp Asp Tyr 
    1580                 1585                 1590             


Ser Glu  Phe Val Gln Arg Glu  Thr Asp Ile Glu Asp  Ser Asp Asp 
    1595                 1600                 1605             


Ile Pro  Glu Asp Thr Thr Tyr  Lys Lys Val Val Phe  Arg Lys Tyr 
    1610                 1615                 1620             


Leu Asp  Ser Thr Phe Thr Lys  Arg Asp Pro Arg Gly  Glu Tyr Glu 
    1625                 1630                 1635             


Glu His  Leu Gly Ile Leu Gly  Pro Ile Ile Arg Ala  Glu Val Asp 
    1640                 1645                 1650             


Asp Val  Ile Gln Val Arg Phe  Lys Asn Leu Ala Ser  Arg Pro Tyr 
    1655                 1660                 1665             


Ser Leu  His Ala His Gly Leu  Ser Tyr Glu Lys Ser  Ser Glu Gly 
    1670                 1675                 1680             


Lys Thr  Tyr Glu Asp Asp Ser  Pro Glu Trp Phe Lys  Glu Asp Asn 
    1685                 1690                 1695             


Ala Val  Gln Pro Asn Ser Ser  Tyr Thr Tyr Val Trp  His Ala Thr 
    1700                 1705                 1710             


Glu Arg  Ser Gly Pro Glu Ser  Pro Gly Ser Ala Cys  Arg Ala Trp 
    1715                 1720                 1725             


Ala Tyr  Tyr Ser Ala Val Asn  Pro Glu Lys Asp Ile  His Ser Gly 
    1730                 1735                 1740             


Leu Ile  Gly Pro Leu Leu Ile  Cys Gln Lys Gly Ile  Leu His Lys 
    1745                 1750                 1755             


Asp Ser  Asn Met Pro Met Asp  Met Arg Glu Phe Val  Leu Leu Phe 
    1760                 1765                 1770             


Met Thr  Phe Asp Glu Lys Lys  Ser Trp Tyr Tyr Glu  Lys Lys Ser 
    1775                 1780                 1785             


Arg Ser  Ser Trp Arg Leu Thr  Ser Ser Glu Met Lys  Lys Ser His 
    1790                 1795                 1800             


Glu Phe  His Ala Ile Asn Gly  Met Ile Tyr Ser Leu  Pro Gly Leu 
    1805                 1810                 1815             


Lys Met  Tyr Glu Gln Glu Trp  Val Arg Leu His Leu  Leu Asn Ile 
    1820                 1825                 1830             


Gly Gly  Ser Gln Asp Ile His  Val Val His Phe His  Gly Gln Thr 
    1835                 1840                 1845             


Leu Leu  Glu Asn Gly Asn Lys  Gln His Gln Leu Gly  Val Trp Pro 
    1850                 1855                 1860             


Leu Leu  Pro Gly Ser Phe Lys  Thr Leu Glu Met Lys  Ala Ser Lys 
    1865                 1870                 1875             


Pro Gly  Trp Trp Leu Leu Asn  Thr Glu Val Gly Glu  Asn Gln Arg 
    1880                 1885                 1890             


Ala Gly  Met Gln Thr Pro Phe  Leu Ile Met Asp Arg  Asp Cys Arg 
    1895                 1900                 1905             


Met Pro  Met Gly Leu Ser Thr  Gly Ile Ile Ser Asp  Ser Gln Ile 
    1910                 1915                 1920             


Lys Ala  Ser Glu Phe Leu Gly  Tyr Trp Glu Pro Arg  Leu Ala Arg 
    1925                 1930                 1935             


Leu Asn  Asn Gly Gly Ser Tyr  Asn Ala Trp Ser Val  Glu Lys Leu 
    1940                 1945                 1950             


Ala Ala  Glu Phe Ala Ser Lys  Pro Trp Ile Gln Val  Asp Met Gln 
    1955                 1960                 1965             


Lys Glu  Val Ile Ile Thr Gly  Ile Gln Thr Gln Gly  Ala Lys His 
    1970                 1975                 1980             


Tyr Leu  Lys Ser Cys Tyr Thr  Thr Glu Phe Tyr Val  Ala Tyr Ser 
    1985                 1990                 1995             


Ser Asn  Gln Ile Asn Trp Gln  Ile Phe Lys Gly Asn  Ser Thr Arg 
    2000                 2005                 2010             


Asn Val  Met Tyr Phe Asn Gly  Asn Ser Asp Ala Ser  Thr Ile Lys 
    2015                 2020                 2025             


Glu Asn  Gln Phe Asp Pro Pro  Ile Val Ala Arg Tyr  Ile Arg Ile 
    2030                 2035                 2040             


Ser Pro  Thr Arg Ala Tyr Asn  Arg Pro Thr Leu Arg  Leu Glu Leu 
    2045                 2050                 2055             


Gln Gly  Cys Glu Val Asn Gly  Cys Ser Thr Pro Leu  Gly Met Glu 
    2060                 2065                 2070             


Asn Gly  Lys Ile Glu Asn Lys  Gln Ile Thr Ala Ser  Ser Phe Lys 
    2075                 2080                 2085             


Lys Ser  Trp Trp Gly Asp Tyr  Trp Glu Pro Phe Arg  Ala Arg Leu 
    2090                 2095                 2100             


Asn Ala  Gln Gly Arg Val Asn  Ala Trp Gln Ala Lys  Ala Asn Asn 
    2105                 2110                 2115             


Asn Lys  Gln Trp Leu Glu Ile  Asp Leu Leu Lys Ile  Lys Lys Ile 
    2120                 2125                 2130             


Thr Ala  Ile Ile Thr Gln Gly  Cys Lys Ser Leu Ser  Ser Glu Met 
    2135                 2140                 2145             


Tyr Val  Lys Ser Tyr Thr Ile  His Tyr Ser Glu Gln  Gly Val Glu 
    2150                 2155                 2160             


Trp Lys  Pro Tyr Arg Leu Lys  Ser Ser Met Val Asp  Lys Ile Phe 
    2165                 2170                 2175             


Glu Gly  Asn Thr Asn Thr Lys  Gly His Val Lys Asn  Phe Phe Asn 
    2180                 2185                 2190             


Pro Pro  Ile Ile Ser Arg Phe  Ile Arg Val Ile Pro  Lys Thr Trp 
    2195                 2200                 2205             


Asn Gln  Ser Ile Ala Leu Arg  Leu Glu Leu Phe Gly  Cys Asp Ile 
    2210                 2215                 2220             


Tyr 
    


<210>  349
<211>  2488
<212>  DNA
<213>  Homo sapiens

<400>  349
cgctgccagc ccgcccgcca gccaggggct ccgccgccct cgcctcggcc tcgttagccc     60

gccaggagcc ccgcagctcc tccgggagcc cgctggtaac tcgcgtccct cgcgcttctc    120

cggcgcctga ggggcccgcc tcgggccatg gtgctctccc aggaggagcc ggactccgcg    180

cggggcacga gcgaggcgca gccgctcggc cccgcgccca cgggggccgc tccgccgccc    240

ggcccgggac cctcggacag ccccgaggcg gctgtcgaga aggtggaggt ggagctggcg    300

gggccggcga ccgcggagcc ccatgagccc cccgaacccc ccgagggcgg ctggggctgg    360

ctggtgatgc tggcggccat gtggtgcaac gggtcggtgt tcggcatcca gaacgcttgc    420

ggggtgctct tcgtgtccat gctggaaacc ttcggctcca aagacgatga caagatggtc    480

tttaagacag catgggtagg ttctctctcc atggggatga ttttcttttg ctgcccaata    540

gtcagcgtct tcacagacct atttggttgt cggaaaacag ctgtcgtggg tgctgctgtt    600

ggatttgttg ggctcatgtc cagttctttt gtaagttcca tcgagcctct gtaccttacc    660

tatggaatca tatttgcctg cggctgctcc tttgcatacc agccttcatt ggtcattttg    720

ggacactatt tcaagaagcg ccttggactg gtgaatggca ttgtcactgc tggcagcagt    780

gtcttcacaa tcctgctgcc tttgctctta agggttctga ttgacagcgt gggcctcttt    840

tacacattga gggtgctctg catcttcatg tttgttctct ttctggctgg ctttacttac    900

cgacctcttg ctaccagtac caaagataaa gagagtggag gtagcggatc ctccctcttt    960

tccaggaaaa agttcagtcc tccaaaaaaa attttcaatt ttgccatctt caaggtgaca   1020

gcttatgcag tgtgggcagt tggaatacca cttgcacttt ttggatactt tgtgccttat   1080

gttcacttga tgaaacatgt aaatgaaaga tttcaagatg aaaaaaataa agaggttgtt   1140

ctcatgtgca ttggcgtcac ttcaggagtt ggacgactgc tctttggccg gattgcagat   1200

tatgtgcctg gtgtgaagaa ggtttatcta caggtactct cctttttctt cattggtctg   1260

atgtccatga tgattcctct gtgtagcatc tttggggccc tcattgctgt gtgcctcatc   1320

atgggtctct tcgatggatg cttcatttcc attatggctc ccatagcctt tgagttagtt   1380

ggtgcccagg atgtctccca agcaattgga tttctgctcg gattcatgtc tatacccatg   1440

actgttggcc cacccattgc agggttactt cgtgacaaac tgggctccta tgatgtggca   1500

ttctacctcg ctggagtccc tccccttatt ggaggtgctg tgctttgttt tatcccgtgg   1560

atccatagta agaagcaaag agagatcagt aaaaccactg gaaaagaaaa gatggagaaa   1620

atgttggaaa accagaactc tctgctgtca agttcatctg gaatgttcaa gaaagaatct   1680

gactctatta tttaatatct tacatacctc caccagactg gacttgcttt ttgaatttta   1740

agcaagtttc ctttcctttt atacaaattg caaatttcat atttttttaa tcacatccta   1800

ggaatagcac aataattggg aaatagaacc cttatcacta gaagaaccat tttctgccac   1860

taaatatctc tgatgtttcc atgagtctga gggcagagac tctggtatat gaaaacatgt   1920

ctgaaagtca catattgtga aaatttgaag ctatctcagt aaaaagcagc tttggaaact   1980

gtgaatgatc tttagcttgt acaaatgttt aaaaatacct caggctatac tgaaagggtt   2040

gcagtttggt taggagtgga aatattttgt ttgttaatga tgtcttcagt tctggtacct   2100

ctgttttact ttcttatgct ctttggaaac tttttgcaaa atttaagcct gggttctaga   2160

taataccaga tctacctaaa cctcaagtct atgttaaagt tgctttcctg ctgttaaata   2220

agctatgata ttaagatatt ctgacttgct ccagtgtcaa gggaccttct gggagcaggt   2280

gccaacatag tgttcagaat caatatgtga gatgaaaagg atcccctcca ggaggatcct   2340

gagctgttca gaaatcattt aagtttacag cgttgttccc tttgcgtttg cagtgcgttt   2400

tactcaagta gccagaaaca ccccacgttt ctgaatttgt ttaaactgta acaataaagt   2460

aaaatagaat gcaaaaaaaa aaaaaaaa                                      2488


<210>  350
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Val Leu Ser Gln Glu Glu Pro Asp Ser Ala Arg Gly Thr Ser Glu 
1               5                   10                  15      


Ala Gln Pro Leu Gly Pro Ala Pro Thr Gly Ala Ala Pro Pro Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Asp Ser Pro Glu Ala Ala Val Glu Lys Val Glu Val 
        35                  40                  45              


Glu Leu Ala Gly Pro Ala Thr Ala Glu Pro His Glu Pro Pro Glu Pro 
    50                  55                  60                  


Pro Glu Gly Gly Trp Gly Trp Leu Val Met Leu Ala Ala Met Trp Cys 
65                  70                  75                  80  


Asn Gly Ser Val Phe Gly Ile Gln Asn Ala Cys Gly Val Leu Phe Val 
                85                  90                  95      


Ser Met Leu Glu Thr Phe Gly Ser Lys Asp Asp Asp Lys Met Val Phe 
            100                 105                 110         


Lys Thr Ala Trp Val Gly Ser Leu Ser Met Gly Met Ile Phe Phe Cys 
        115                 120                 125             


Cys Pro Ile Val Ser Val Phe Thr Asp Leu Phe Gly Cys Arg Lys Thr 
    130                 135                 140                 


Ala Val Val Gly Ala Ala Val Gly Phe Val Gly Leu Met Ser Ser Ser 
145                 150                 155                 160 


Phe Val Ser Ser Ile Glu Pro Leu Tyr Leu Thr Tyr Gly Ile Ile Phe 
                165                 170                 175     


Ala Cys Gly Cys Ser Phe Ala Tyr Gln Pro Ser Leu Val Ile Leu Gly 
            180                 185                 190         


His Tyr Phe Lys Lys Arg Leu Gly Leu Val Asn Gly Ile Val Thr Ala 
        195                 200                 205             


Gly Ser Ser Val Phe Thr Ile Leu Leu Pro Leu Leu Leu Arg Val Leu 
    210                 215                 220                 


Ile Asp Ser Val Gly Leu Phe Tyr Thr Leu Arg Val Leu Cys Ile Phe 
225                 230                 235                 240 


Met Phe Val Leu Phe Leu Ala Gly Phe Thr Tyr Arg Pro Leu Ala Thr 
                245                 250                 255     


Ser Thr Lys Asp Lys Glu Ser Gly Gly Ser Gly Ser Ser Leu Phe Ser 
            260                 265                 270         


Arg Lys Lys Phe Ser Pro Pro Lys Lys Ile Phe Asn Phe Ala Ile Phe 
        275                 280                 285             


Lys Val Thr Ala Tyr Ala Val Trp Ala Val Gly Ile Pro Leu Ala Leu 
    290                 295                 300                 


Phe Gly Tyr Phe Val Pro Tyr Val His Leu Met Lys His Val Asn Glu 
305                 310                 315                 320 


Arg Phe Gln Asp Glu Lys Asn Lys Glu Val Val Leu Met Cys Ile Gly 
                325                 330                 335     


Val Thr Ser Gly Val Gly Arg Leu Leu Phe Gly Arg Ile Ala Asp Tyr 
            340                 345                 350         


Val Pro Gly Val Lys Lys Val Tyr Leu Gln Val Leu Ser Phe Phe Phe 
        355                 360                 365             


Ile Gly Leu Met Ser Met Met Ile Pro Leu Cys Ser Ile Phe Gly Ala 
    370                 375                 380                 


Leu Ile Ala Val Cys Leu Ile Met Gly Leu Phe Asp Gly Cys Phe Ile 
385                 390                 395                 400 


Ser Ile Met Ala Pro Ile Ala Phe Glu Leu Val Gly Ala Gln Asp Val 
                405                 410                 415     


Ser Gln Ala Ile Gly Phe Leu Leu Gly Phe Met Ser Ile Pro Met Thr 
            420                 425                 430         


Val Gly Pro Pro Ile Ala Gly Leu Leu Arg Asp Lys Leu Gly Ser Tyr 
        435                 440                 445             


Asp Val Ala Phe Tyr Leu Ala Gly Val Pro Pro Leu Ile Gly Gly Ala 
    450                 455                 460                 


Val Leu Cys Phe Ile Pro Trp Ile His Ser Lys Lys Gln Arg Glu Ile 
465                 470                 475                 480 


Ser Lys Thr Thr Gly Lys Glu Lys Met Glu Lys Met Leu Glu Asn Gln 
                485                 490                 495     


Asn Ser Leu Leu Ser Ser Ser Ser Gly Met Phe Lys Lys Glu Ser Asp 
            500                 505                 510         


Ser Ile Ile 
        515 


<210>  351
<211>  517
<212>  DNA
<213>  Homo sapiens

<400>  351
cctccacagc aacttccttg atccctgcca cgcacgactg aacacagaca gcagccgcct     60

cgccatgaag ctgctgatgg tcctcatgct ggcggccctc ctcctgcact gctatgcaga    120

ttctggctgc aaactcctgg aggacatggt tgaaaagacc atcaattccg acatatctat    180

acctgaatac aaagagcttc ttcaagagtt catagacagt gatgccgctg cagaggctat    240

ggggaaattc aagcagtgtt tcctcaacca gtcacataga actctgaaaa actttggact    300

gatgatgcat acagtgtacg acagcatttg gtgtaatatg aagagtaatt aactttaccc    360

aaggcgtttg gctcagaggg ctacagacta tggccagaac tcatctgttg attgctagaa    420

accacttttc tttcttgtgt tgtcttttta tgtggaaact gctagacaac tgttgaaacc    480

tcaaattcat ttccatttca ataactaact gcaaatc                             517


<210>  352
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Lys Leu Leu Met Val Leu Met Leu Ala Ala Leu Leu Leu His Cys 
1               5                   10                  15      


Tyr Ala Asp Ser Gly Cys Lys Leu Leu Glu Asp Met Val Glu Lys Thr 
            20                  25                  30          


Ile Asn Ser Asp Ile Ser Ile Pro Glu Tyr Lys Glu Leu Leu Gln Glu 
        35                  40                  45              


Phe Ile Asp Ser Asp Ala Ala Ala Glu Ala Met Gly Lys Phe Lys Gln 
    50                  55                  60                  


Cys Phe Leu Asn Gln Ser His Arg Thr Leu Lys Asn Phe Gly Leu Met 
65                  70                  75                  80  


Met His Thr Val Tyr Asp Ser Ile Trp Cys Asn Met Lys Ser Asn 
                85                  90                  95  


<210>  353
<211>  1854
<212>  DNA
<213>  Homo sapiens

<400>  353
gcccgctgcg gtcacgctgc gcccggcgcc gcagggtggg cggcgaggca ctcacgaggg     60

ggacgctgag ggcttccgcg cgggccaccc gggtcaagcg cgctccgccg ggaaacttct    120

gcgggcgccg ggctgaagct ccgggcaggg ctgggaagga aaggaaatac caaaatattt    180

gcagactgga tccaaatcag gagcccagat gaacttaaag aagcgagcat gggattctta    240

gtttttcaag atccgtacac acgaagcctt taatcagcat caactccagt gtccgttttc    300

tctggttttg tgaagactgc acaaaactct catgatggag aaccaaagga cttagttacc    360

tgtttcagtg tcatctaaag tcaactgaaa agtgaagcag gcagtaatac agccatggaa    420

agaaattcaa gtttatggaa gaacctaata gatgaacacc cagtctgcac aacctggaag    480

caagaggccg aaggagccat ttatcatctt gccagtattt tatttgtagt aggtttcatg    540

ggtggcagtg gattcttcgg gctcctttat gtcttcagtt tgctggggtt gggttttctc    600

tgttctgctg tctgggcttg ggtagatgtc tgtgcagctg acatattttc ctggaatttt    660

gtactgtttg tcatctgctt catgcaattt gttcatattg catatcaagt tcgcagcata    720

acctttgccc gagaattcca agtgttgtac agctcccttt tccagcccct ggggatctct    780

ttgcctgtct tcagaacgat tgctttgagc tctgaagtgg ttactttgga aaaggaacac    840

tgttatgcca tgcaggggaa aacttccatt gataaactct ccttgcttgt ttcaggaagg    900

atcagagtga cagttgatgg cgaatttctg cattacattt tcccccttca gttcctggat    960

tctcctgagt gggattcact gagacccaca gaggaaggca tttttcaggt aaccctcact   1020

gcagaaactg attgtcgata tgtgtcttgg aggagaaaga aattatatct gctctttgct   1080

cagcatcgct acatctcccg ccttttttca gtgctaattg gcagtgacat tgcagataaa   1140

ctctatgcct tgaatgacag ggtatatata ggaaaaagat atcactatga tattcggcta   1200

cccaacttct atcaaatgtc aactccagaa atacgcagat cacccctgac acaacatttt   1260

cagaattcca gacgatactg tgataaatga catcaaagtc tgaaatttat aagtataaaa   1320

aaagactctc tcttcatcat tccccagtga aatagcaaaa tacaaaaaaa gagctcccta   1380

atgtttttat aaatcaaatt cagaagcgag atgccattgc caactgtttt attcctttca   1440

acaactgcat tgtgaataaa ctttacaaat ttttcttgta tttctcattg ttataattgg   1500

ggagggggtg gataactatg ggcagtttgc ccttttctgc atcaaaactg ggagaatgaa   1560

attccacttt ctcaattctt ttctcacatt tactcaaatg cattgtcttg ccctatggac   1620

tcaggagttg cttctcaaga aacagccagc aagtattctc agcctgaggg tgggttgcta   1680

ctgtccacat aggcatttcc ggaattcact tttttgctac aacctccagt gaaagcaatt   1740

attttaaatg tgcagttact tgatgtgact aaaaagtaga ataaatgcaa gagataataa   1800

tatgtgaatc ttgaagccta ttttattgct acaaataaaa taacatttaa aaag         1854


<210>  354
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Glu Arg Asn Ser Ser Leu Trp Lys Asn Leu Ile Asp Glu His Pro 
1               5                   10                  15      


Val Cys Thr Thr Trp Lys Gln Glu Ala Glu Gly Ala Ile Tyr His Leu 
            20                  25                  30          


Ala Ser Ile Leu Phe Val Val Gly Phe Met Gly Gly Ser Gly Phe Phe 
        35                  40                  45              


Gly Leu Leu Tyr Val Phe Ser Leu Leu Gly Leu Gly Phe Leu Cys Ser 
    50                  55                  60                  


Ala Val Trp Ala Trp Val Asp Val Cys Ala Ala Asp Ile Phe Ser Trp 
65                  70                  75                  80  


Asn Phe Val Leu Phe Val Ile Cys Phe Met Gln Phe Val His Ile Ala 
                85                  90                  95      


Tyr Gln Val Arg Ser Ile Thr Phe Ala Arg Glu Phe Gln Val Leu Tyr 
            100                 105                 110         


Ser Ser Leu Phe Gln Pro Leu Gly Ile Ser Leu Pro Val Phe Arg Thr 
        115                 120                 125             


Ile Ala Leu Ser Ser Glu Val Val Thr Leu Glu Lys Glu His Cys Tyr 
    130                 135                 140                 


Ala Met Gln Gly Lys Thr Ser Ile Asp Lys Leu Ser Leu Leu Val Ser 
145                 150                 155                 160 


Gly Arg Ile Arg Val Thr Val Asp Gly Glu Phe Leu His Tyr Ile Phe 
                165                 170                 175     


Pro Leu Gln Phe Leu Asp Ser Pro Glu Trp Asp Ser Leu Arg Pro Thr 
            180                 185                 190         


Glu Glu Gly Ile Phe Gln Val Thr Leu Thr Ala Glu Thr Asp Cys Arg 
        195                 200                 205             


Tyr Val Ser Trp Arg Arg Lys Lys Leu Tyr Leu Leu Phe Ala Gln His 
    210                 215                 220                 


Arg Tyr Ile Ser Arg Leu Phe Ser Val Leu Ile Gly Ser Asp Ile Ala 
225                 230                 235                 240 


Asp Lys Leu Tyr Ala Leu Asn Asp Arg Val Tyr Ile Gly Lys Arg Tyr 
                245                 250                 255     


His Tyr Asp Ile Arg Leu Pro Asn Phe Tyr Gln Met Ser Thr Pro Glu 
            260                 265                 270         


Ile Arg Arg Ser Pro Leu Thr Gln His Phe Gln Asn Ser Arg Arg Tyr 
        275                 280                 285             


Cys Asp Lys 
    290     


<210>  355
<211>  3954
<212>  DNA
<213>  Homo sapiens

<400>  355
agggggaggt gggcagccgg ccagggaagc acggtccagg cggctacatt cggcccggcc     60

atggcagcgg cgcccctgaa agtgtgcatc gtgggctcgg ggaactgggg ttcagctgtt    120

gcaaaaataa ttggtaataa tgtcaagaaa cttcagaaat ttgcctccac agtcaagatg    180

tgggtctttg aagaaacagt gaatggcaga aaactgacag acatcataaa taatgaccat    240

gaaaatgtaa aatatcttcc tggacacaag ctgccagaaa atgtggttgc catgtcaaat    300

cttagcgagg ctgtgcagga tgcagacctg ctggtgtttg tcattcccca ccagttcatt    360

cacagaatct gtgatgagat cactgggaga gtgcccaaga aagcgctggg aatcaccctc    420

atcaagggca tagacgaggg ccccgagggg ctgaagctca tttctgacat catccgtgag    480

aagatgggta ttgacatcag tgtgctgatg ggagccaaca ttgccaatga ggtggctgca    540

gagaagttct gtgagaccac catcggcagc aaagtaatgg agaacggcct tctcttcaaa    600

gaacttctgc agactccaaa ttttcgaatt accgtggttg atgatgcaga cactgttgaa    660

ctatgtggtg cgcttaagaa catcgtagct gtgggagctg ggttctgcga cggcctccgc    720

tgtggagaca acaccaaagc ggccgtcatc cgcctgggac tcatggaaat gattgctttt    780

gccaggatct tctgcaaagg ccaagtgtct acagccacct tcctagagag ctgcggggtg    840

gccgacctga tcaccacctg ttacggaggg cggaaccgca gggtggccga ggccttcgcc    900

agaactggga agaccattga agagttggag aaggagatgc tgaatgggca aaagctccaa    960

ggaccgcaga cttctgctga agtgtaccgc atcctcaaac agaagggact actggacaag   1020

tttccattgt ttactgcagt gtatcagatc tgctacgaaa gcagaccagt tcaagagatg   1080

ttgtcttgtc ttcagagcca tccagagcat acataaagtg aatcatgcaa cgtgttgggg   1140

gaagttctgc ctttctgatc aatcttttgg gttcacgtgg aaaccaggac ttggcaacat   1200

gatgtttgac tgtaatctca tcacggatat gtatgaattt ttacaggttc gtttttgaat   1260

tgtgagaggc agttcattag caaagatgta ctgggcagta actaaacaca catgcaaaca   1320

tgtgaatggt ggtttattcc tcattctgtg gatgtttcta tgagccaaaa tttgatgtct   1380

ttttttcaaa attgcttatg aaatttccac acaatcgtag cttataagat tggaacgatc   1440

tcagccaaat attttaggtg taattcatat gtatttgagt ggaggatttt ttttctcatt   1500

tttctagtgt taaattttaa ccagcattaa catggtagag tggaggagtg agtgtgttca   1560

aagatcaaca tatttaactt ttaaacacta tctcaaagcc agcataatta actactttga   1620

ttgtgggctg acctttgttt ttttaacaat caggcatttt taattagata atccactcat   1680

gtatttcccc ctcactgcag ttgtctgcat ttttagcctc ttttctcttc gttagttgtc   1740

agaatatgcc ttcgtcaagg ctcagaggta acaagacaga aaattcatct gggattttcc   1800

tgctgtggct ggcacattct tctgattaac agacacttgt atgatgcttt aggctagtta   1860

gtgcattttt tagcaaacat ttatcttaaa catcacagat ccactggggg gtgcaagggg   1920

ctactgttag tcctcttgtt agatgcagtc actcctcctg gtcacctagt gagcagggac   1980

agagccagga gtcaagtgca gtgccaaggt gcatgaccct ctgagaagtc actgggctga   2040

tttgacctcc gactcattgg ttgtgcaaat gccatgtgca gcctttcctg aggccatagg   2100

agggcttcct gcagctgaga tctatgcagg ccatcctctc aacaagtgcc actccaaggg   2160

cggtcctcgg tgcagcagca tcagcttcac ttgtgggggg gtgggggaag gggcggtctc   2220

agaaatgcag gttcccaggt cccaccctgg acttctgaag gggtgtggca tctgtgtttc   2280

tgatgcttac tacaatatgt gaaccactac tttagaaaat ctgctttaac ttggtattcc   2340

tctaattgtg ttccctagga aatgactgtc ccaagagcca gtgattattc caggtgttcc   2400

ctggaaaggt caagtgagtc tgggaaacac tatgtctgta cacctcttga aggtgtcgaa   2460

tgtatgttta tacatcagtg gaacccattt ttctagccta gcaagtccca aacacattac   2520

actgaagaga ttttggtgag gaaacttgct ggagttttca gggaacactg ttctaggctt   2580

aggtgacctt aggatcactc aagtagacgc ttcactccct gcgagaaatt aggatgaata   2640

actacctgtg gcattgttgg ttctgaactt ttacagttca ggcctgctgt gaatctttga   2700

tgaagcttta aggtgacact gttgtacaag atgtcagctt tgctgaaacg cacattacct   2760

ggaataagtg ctttaattgt agaattagaa tgggatttac tgtactgttt taaatgagat   2820

tggcttcaga atccattaca gttaccttac atagcacttg atacgtgtta aatgaacata   2880

tgaatgtaat ttatatattc ctagaattta agttactttg tgagatttgg gcctgtccct   2940

caatgccagt ttaggatttc tttttttcta taccttgaaa tgattataaa atagattttc   3000

atgggaattt taaaaactct atccaaaaca tttttggagc attttaaagc cccatacaca   3060

gaagtatacg aaagcacaca aaacactcca agtttcagca gttttagcgc caccattaac   3120

ccactttgct tgtctcatga aaaatctttg ttaaagtttg tacacaggta acaaaaagtt   3180

actttaaaag atatataaag ggctgtaagc taattgtggt gtctagtaag tagcataatg   3240

agatgtgagg agttggaact ttgcgtgttt tgcgtatttt catctgcatt cagcttctta   3300

ctctgggttt gtactcgagt gttatttctt tacaaatgcc cttgtaatta ccactctgaa   3360

gtctgctgac tgtgtctctt gaacatactt aggatattct gcacattatg gaaaaaggta   3420

aattttagaa gtttctgctc tactaactgt agatatttat gactctgcga gttatctatt   3480

tttataacca cctgtggtcc attgttcatt ttaattcaca tttcttatga agtatggtaa   3540

cagggaggga gacacctaga ttagcagctc aatttgtact acttcagcca atctgtgaat   3600

gtaaaaacta cactgttgcc ttgctaggat ccaccctcct ataatatgga acaaatatct   3660

gaatgaaatc caccctagga gacggagtca aactaaactt gtggtttttc atttaacttt   3720

tgactacagc atggccccat ggcatccaca ccaagagggt gttgtgatga ggtgccggtg   3780

tgcaaaggga actttagttt ttccactggt tcttatctgc tagcctttta catacatgtg   3840

tactatattt gtttatagac tgtaggtgga tatataattt aaaagcttga tttaataaac   3900

atttaacccc ataaaaaaaa aaaaaaaaaa aaaaaaagaa aaaaaaaaaa aaaa         3954


<210>  356
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Ala Ala Ala Pro Leu Lys Val Cys Ile Val Gly Ser Gly Asn Trp 
1               5                   10                  15      


Gly Ser Ala Val Ala Lys Ile Ile Gly Asn Asn Val Lys Lys Leu Gln 
            20                  25                  30          


Lys Phe Ala Ser Thr Val Lys Met Trp Val Phe Glu Glu Thr Val Asn 
        35                  40                  45              


Gly Arg Lys Leu Thr Asp Ile Ile Asn Asn Asp His Glu Asn Val Lys 
    50                  55                  60                  


Tyr Leu Pro Gly His Lys Leu Pro Glu Asn Val Val Ala Met Ser Asn 
65                  70                  75                  80  


Leu Ser Glu Ala Val Gln Asp Ala Asp Leu Leu Val Phe Val Ile Pro 
                85                  90                  95      


His Gln Phe Ile His Arg Ile Cys Asp Glu Ile Thr Gly Arg Val Pro 
            100                 105                 110         


Lys Lys Ala Leu Gly Ile Thr Leu Ile Lys Gly Ile Asp Glu Gly Pro 
        115                 120                 125             


Glu Gly Leu Lys Leu Ile Ser Asp Ile Ile Arg Glu Lys Met Gly Ile 
    130                 135                 140                 


Asp Ile Ser Val Leu Met Gly Ala Asn Ile Ala Asn Glu Val Ala Ala 
145                 150                 155                 160 


Glu Lys Phe Cys Glu Thr Thr Ile Gly Ser Lys Val Met Glu Asn Gly 
                165                 170                 175     


Leu Leu Phe Lys Glu Leu Leu Gln Thr Pro Asn Phe Arg Ile Thr Val 
            180                 185                 190         


Val Asp Asp Ala Asp Thr Val Glu Leu Cys Gly Ala Leu Lys Asn Ile 
        195                 200                 205             


Val Ala Val Gly Ala Gly Phe Cys Asp Gly Leu Arg Cys Gly Asp Asn 
    210                 215                 220                 


Thr Lys Ala Ala Val Ile Arg Leu Gly Leu Met Glu Met Ile Ala Phe 
225                 230                 235                 240 


Ala Arg Ile Phe Cys Lys Gly Gln Val Ser Thr Ala Thr Phe Leu Glu 
                245                 250                 255     


Ser Cys Gly Val Ala Asp Leu Ile Thr Thr Cys Tyr Gly Gly Arg Asn 
            260                 265                 270         


Arg Arg Val Ala Glu Ala Phe Ala Arg Thr Gly Lys Thr Ile Glu Glu 
        275                 280                 285             


Leu Glu Lys Glu Met Leu Asn Gly Gln Lys Leu Gln Gly Pro Gln Thr 
    290                 295                 300                 


Ser Ala Glu Val Tyr Arg Ile Leu Lys Gln Lys Gly Leu Leu Asp Lys 
305                 310                 315                 320 


Phe Pro Leu Phe Thr Ala Val Tyr Gln Ile Cys Tyr Glu Ser Arg Pro 
                325                 330                 335     


Val Gln Glu Met Leu Ser Cys Leu Gln Ser His Pro Glu His Thr 
            340                 345                 350     


<210>  357
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  357
ccaagggagt ggccctatca aat                                             23


<210>  358
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  358
ccatagaggt gccaggagca cggatcct                                        28


<210>  359
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  359
ggatggtcag cattcaattc atcct                                           25


<210>  360
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  360
cgcaagctgc tggagggtg                                                  19


<210>  361
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  361
ggagtgcagg ctgaatggcg aaggc                                           25


<210>  362
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  362
ctggagacgg tggactgcac c                                               21


<210>  363
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  363
tcccatttct ttcagccaga tcct                                            24


<210>  364
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  364
cccagggaat cactacaggc tggttagcca                                      30


<210>  365
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  365
aaggtaacat tggacatgct gcctt                                           25


<210>  366
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  366
accatggtag aagttggagc accat                                           25


<210>  367
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  367
tgttctcctg cctactggaa gccaagcact                                      30


<210>  368
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  368
atttgaaaac ccacttctcc accaa                                           25


<210>  369
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  369
catgatgtgc agttctctgg agca                                            24


<210>  370
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  370
gctggctgtg ctggtcacta ccttccaca                                       29


<210>  371
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  371
tcgccctctt ggcaggagta ct                                              22


<210>  372
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  372
cagctgcgtg agtaccagga actc                                            24


<210>  373
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  373
gcgtgaagct ggccctggac atcg                                            24


<210>  374
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  374
agcagcttgc ggtaggtggc                                                 20


<210>  375
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  375
ttgctgagcc ctttgctccc                                                 20


<210>  376
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  376
cgactgcctg gacagtcagc aaggaattgt                                      30


<210>  377
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  377
agccagagtt ggcagccagg                                                 20


<210>  378
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  378
gtgaggaaca cgccggcc                                                   18


<210>  379
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  379
tgcatcgagc cttgaagggt attggaactg                                      30


<210>  380
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  380
tctggacacc attattcggt tcaga                                           25


<210>  381
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  381
agaggcagct gtcacgggag tt                                              22


<210>  382
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  382
ggccgtgttc cattcaatgg acaagatcc                                       29


<210>  383
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  383
ctggaccttt gactggctct tgc                                             23


<210>  384
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  384
ttgtgtttgg gtgatcatgg ctg                                             23


<210>  385
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  385
gccaaacatc atcctgacaa atggtcagcc                                      30


<210>  386
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  386
agctgttcac ataggtgact gccg                                            24


<210>  387
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  387
tcctctggat atggcagtgg ca                                              22


<210>  388
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  388
tatggcggtg gcctcggtgg agg                                             23


<210>  389
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  389
ccaccgaggc cgccg                                                      15


<210>  390
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  390
gagcacctgg aagcagtaac atgc                                            24


<210>  391
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  391
agcaagaata tttcggtgaa cggtgtgggg                                      30


<210>  392
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  392
ggcagctatg gctgctaatg ca                                              22


<210>  393
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  393
atggaggacg ccttcaacaa gg                                              22


<210>  394
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  394
tgttccacca agccatggtg gatgtgaa                                        28


<210>  395
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  395
gctgcttcag tgccctcctc a                                               21


<210>  396
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  396
caccgactgt gactccggca                                                 20


<210>  397
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  397
acggtggcga cagcggctct gg                                              22


<210>  398
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  398
cgtcgggctg ggcgg                                                      15


<210>  399
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  399
caggcggccg tggcc                                                      15


<210>  400
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  400
gagacacgca catcatcaag gcgcagag                                        28


<210>  401
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  401
ggtcttgcgg cagtctgtgc t                                               21


<210>  402
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  402
tgtcattgac cctgtgagag gca                                             23


<210>  403
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  403
ttcgtgttcc tccagaaatt gctctgcagc                                      30


<210>  404
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  404
cttgtgttgc tggatggctc atg                                             23


<210>  405
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  405
tggatctgca gccatgccc                                                  19


<210>  406
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  406
agttcctgac ggtgttcctg gccattcc                                        28


<210>  407
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  407
tccagatgtg cagacagctg agg                                             23


<210>  408
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  408
ttgccagccc ggcgag                                                     16


<210>  409
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  409
gagttacctc gtccgagtgg tgagcaccaa                                      30


<210>  410
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  410
cttgaagaac accatagcat gctgg                                           25


<210>  411
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  411
cgagtcccgc cgccg                                                      15


<210>  412
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  412
acggcgacag gctcacgctg gc                                              22


<210>  413
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  413
gcgcacaccg tgtcgacg                                                   18


<210>  414
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  414
tagggtggaa atggatacac gaacc                                           25


<210>  415
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  415
acaatgccaa cttctgtgct ggagcatgc                                       29


<210>  416
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  416
ccctgctgtg ctgagtgtct gaa                                             23


<210>  417
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  417
ggacagcatc aagagtgaga ccca                                            24


<210>  418
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  418
cactggagga ggccatgctc actgtgg                                         27


<210>  419
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  419
gcgtccctgc tcccttcatg                                                 20


<210>  420
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  420
ttcggagaaa ggcattagat ctgga                                           25


<210>  421
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  421
tgaagccctg gagtactatg agcgggcc                                        28


<210>  422
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  422
ttctcaaagt cagcagccag tctca                                           25


<210>  423
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  423
tccaagccct ctcccaacac a                                               21


<210>  424
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  424
aaccaccccg tccgatttgg gtctgat                                         27


<210>  425
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  425
gctgctcttt gtacgtctcc acctt                                           25


<210>  426
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  426
aagcaacagt ttctcattct tcgcc                                           25


<210>  427
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  427
tcatgcatcc aacgtcaagt acaccatgca                                      30


<210>  428
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  428
catcaaagcc tcctgcttct cactt                                           25


<210>  429
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  429
agaagatgag gatggctgtc attgg                                           25


<210>  430
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  430
gggtgcgata tttcttcttg caggtctggc                                      30


<210>  431
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  431
tgccatacca tgctgtggca a                                               21


<210>  432
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  432
ccctggccag gattgctaca gt                                              22


<210>  433
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  433
ctcagtgcca tgggcttcac tgcgg                                           25


<210>  434
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  434
gaggacgagg cgattcccg                                                  19


<210>  435
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  435
ggaacacaaa gcccaggaag ga                                              22


<210>  436
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  436
agggagcaca tcaaaggcaa agagaccacc                                      30


<210>  437
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  437
cgggagcttt ggtggcca                                                   18


<210>  438
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  438
gctggtgcga aaagatctgc aa                                              22


<210>  439
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  439
aaatgcagac aagcagctga gcttcgagga                                      30


<210>  440
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  440
cctcgccatc agcatgatga ac                                              22


<210>  441
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  441
acttctcaaa gccgggtcat gaat                                            24


<210>  442
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  442
tgcttcagat ttggaactgg accccatgaa                                      30


<210>  443
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  443
ccgcagcatc tgcctcagtg                                                 20


<210>  444
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  444
taaataccca ggtgttggga tccag                                           25


<210>  445
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  445
ttgcgcatct tccatttggc gttgg                                           25


<210>  446
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  446
tcggcgacca atgcacattc                                                 20


<210>  447
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  447
ctgtaagtgc aatgcttgtg ctcg                                            24


<210>  448
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  448
atcgtggacc tggagatgct gacagtcagc                                      30


<210>  449
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  449
tcttaacaca gagcttgtgc ggaag                                           25


<210>  450
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  450
atccacagcg agacctccgt g                                               21


<210>  451
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  451
ccgaccatgt cgtctggtcc ctgttca                                         27


<210>  452
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  452
atgaagccca gacagcacca gtt                                             23


<210>  453
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  453
cctgcatctg atggaccagc c                                               21


<210>  454
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  454
cttactggag cagaagcttt cccgagccaa                                      30


<210>  455
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  455
ccagctctga catcatgggc c                                               21


<210>  456
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  456
gctccccaca ggcattgagg                                                 20


<210>  457
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  457
ggtaggctcc tggagcaggt gggcac                                          26


<210>  458
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  458
tggctggccc acaaagcc                                                   18


<210>  459
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  459
gggcatctgt gctgaacgga c                                               21


<210>  460
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  460
cgctatccag aaggccgtct cagaagggt                                       29


<210>  461
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  461
gatagcaatt gccctgaaat ccttg                                           25


<210>  462
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  462
aacaaagggc aagagtgctg acttc                                           25


<210>  463
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  463
cttcgatcct cgtggcctcc ttcctgaat                                       29


<210>  464
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  464
tggtcagtga gcctgggtag gtc                                             23


<210>  465
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  465
agcctgtgag gtccaagcta gagg                                            24


<210>  466
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  466
cctctgagtg ggagctggac cctgtaaagg                                      30


<210>  467
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  467
cccatagcat tcgtctcaga gcag                                            24


<210>  468
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  468
atggacgact gaccacaatc aactg                                           25


<210>  469
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  469
ctgaaactca cctgctttga attggcaccg                                      30


<210>  470
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  470
cagatctcaa ctccccggta ttcc                                            24


<210>  471
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  471
tccagtccag ctcggcaaca                                                 20


<210>  472
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  472
acctgatggc ctatcaccag gaggccag                                        28


<210>  473
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  473
gatgtggctg gagatgcgct t                                               21


<210>  474
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  474
tgggcgccct gaagatgc                                                   18


<210>  475
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  475
ttgtgtttgc aagatctgcg gcaaggc                                         27


<210>  476
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  476
cttgaagcaa ccagggtctg gaa                                             23


<210>  477
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  477
ggaaggccag cttcaccacc t                                               21


<210>  478
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  478
ccgcttgctg tctgccctct ttggc                                           25


<210>  479
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  479
acaactgccc agatgtgcag ga                                              22


<210>  480
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  480
cctgcgggtg gcgctg                                                     16


<210>  481
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  481
tgctcctgct cctggtggcc gc                                              22


<210>  482
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  482
gcactggcag cgcagttcag                                                 20


<210>  483
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  483
cgccctgccc gtgcac                                                     16


<210>  484
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  484
cgcagccgcc ctccgcca                                                   18


<210>  485
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  485
cgcggtcatc ggcgatg                                                    17


<210>  486
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  486
agggaagatg tgcctgtcct gtg                                             23


<210>  487
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  487
ctggtgatga gaccagactc cagctggagg                                      30


<210>  488
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  488
tctgagcgga tgaaggcgaa g                                               21


<210>  489
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  489
tcacaaagga aaaattgacc agtgc                                           25


<210>  490
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  490
tggcagagtg gagatgtgtg gaaggagga                                       29


<210>  491
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  491
agctcgacct tgtaaacgaa gcaa                                            24


<210>  492
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  492
ctagtgctga cctacgggct gatg                                            24


<210>  493
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  493
ggccaaggac cgcagtgagg aggaac                                          26


<210>  494
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  494
ggtgcttctg cacacgctca tt                                              22


<210>  495
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  495
ggtgaccaag gctttccaga tga                                             23


<210>  496
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  496
tcagcttaag aaaggcagcc aagtggaggc                                      30


<210>  497
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  497
tcctgaaact ccaggtcctc tggt                                            24


<210>  498
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  498
atttaccaag gaatcaaaca tgcgg                                           25


<210>  499
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  499
ccttcaagtg cgtgagtgaa cagagcctcc                                      30


<210>  500
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  500
cacctgcagg tgggctgaca                                                 20


<210>  501
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  501
cacgcttcaa tgagaacaac aggag                                           25


<210>  502
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  502
tcggttttcc catttgaaag tgggaaacca                                      30


<210>  503
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  503
ccttgaagtg gtcaggttca acca                                            24


<210>  504
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  504
caacgcagag gatgctcagg aa                                              22


<210>  505
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  505
ttcagtgatg tggagagggc cattgagacc                                      30


<210>  506
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  506
gctgctgggt gaccaggtcc                                                 20


<210>  507
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  507
tctgggattg cttcggggg                                                  19


<210>  508
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  508
aggtcactga ggagggcacc gaggctact                                       29


<210>  509
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  509
gcgtggactg agggagttgc tt                                              22


<210>  510
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  510
gctgcgggaa gatttggaga ac                                              22


<210>  511
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  511
gaaggccttg cctcctgccc aggag                                           25


<210>  512
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  512
tccaccctca tccatgttga catag                                           25


<210>  513
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  513
ggtgcgagga tgcttacccg                                                 20


<210>  514
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  514
cagatagatg acaccatgtt ctgcgccgg                                       29


<210>  515
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  515
cctggcagga gtctctacct gctt                                            24


<210>  516
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  516
caccgcctgc aggaagcag                                                  19


<210>  517
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  517
gcagcgcttc acagctcgcg atga                                            24


<210>  518
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  518
acaagtcaca gaagcagttc aggca                                           25


<210>  519
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  519
cggctgccgc aaggtca                                                    17


<210>  520
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  520
ggcaccctgg acgccaaccg c                                               21


<210>  521
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  521
aactccagct ggaagacgtc atagc                                           25


<210>  522
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  522
aagcagctca cggaactgga gaa                                             23


<210>  523
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  523
gcgcgcccgc agggtgga                                                   18


<210>  524
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  524
gagctgcagg gatgcagcg                                                  19


<210>  525
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  525
tggaggcagc tggcacaaga                                                 20


<210>  526
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  526
gctgaggcct ggctgaatta cccatgct                                        28


<210>  527
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  527
gaatccagga gctcactggg ga                                              22


<210>  528
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  528
cccgggcggg aataagtacc                                                 20


<210>  529
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  529
aactaccagc cgtacccgtg cgcagag                                         27


<210>  530
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  530
agcgcagtac tcatcagtgc cg                                              22


<210>  531
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  531
tatgggcttc tgcgcaccaa                                                 20


<210>  532
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  532
gagggactgt gctctgccaa tgtgactcg                                       29


<210>  533
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  533
tccacagcca gtataggtga aagca                                           25


<210>  534
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  534
aaggacatcg gctggaatga ctg                                             23


<210>  535
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  535
ctggctatca tgccaactac tgcgagggtg                                      30


<210>  536
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  536
ccggacgtgc ctgctatatg g                                               21


<210>  537
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  537
ctcatcgcct ggtgtttgtt gg                                              22


<210>  538
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  538
cctctgagag cacaggtcag ggctgca                                         27


<210>  539
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  539
gcctggccca gtgctgtacc                                                 20


<210>  540
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  540
aagcgcagcc gcagggt                                                    17


<210>  541
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  541
tctctaccct cgagtggtcc ggcgc                                           25


<210>  542
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  542
cggttcctcg actggcagct                                                 20


<210>  543
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  543
gggagtgtca gcagccccac                                                 20


<210>  544
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  544
gtgtgctgct gacccacagt ggaaaacaga                                      30


<210>  545
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  545
tcatgcggcc ttggaggg                                                   18


<210>  546
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  546
gggagaagac tcctacaacc cgaat                                           25


<210>  547
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  547
caccctaaag ccgaaatgcg cccatc                                          26


<210>  548
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  548
cgctgatatc cgggacacca g                                               21


<210>  549
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  549
tatgctgagt tgaaggaccg gttg                                            24


<210>  550
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  550
ggtcagagtt ccatgctggg tgagcagg                                        28


<210>  551
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  551
tctgtcttca cactctggat ccgg                                            24


<210>  552
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  552
attgagcaga ccatcaagtc aggct                                           25


<210>  553
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  553
gcaggttgga cagcagcgca cgttc                                           25


<210>  554
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  554
gcttcagggc ttctctgcac ttg                                             23


<210>  555
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  555
aggcccaggc cgccac                                                     16


<210>  556
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  556
ctgcaaccac actgtgatgg ccctaatgg                                       29


<210>  557
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  557
atctctccct caagctcctc cactt                                           25


<210>  558
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  558
aggaggacaa gccagcatgt gtc                                             23


<210>  559
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  559
catgcggacc tcctggccgt gg                                              22


<210>  560
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  560
aggcggtgat ggcctgctt                                                  19


<210>  561
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  561
ctgcagggaa tgcttcgcg                                                  19


<210>  562
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  562
gcgagaacca cttccacgca cgacg                                           25


<210>  563
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  563
ggccacacgt ggcgcac                                                    17


<210>  564
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  564
ttcccagctg ggagcacaga g                                               21


<210>  565
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  565
tccaatcaga tcaccctcgt ggaagacgtc                                      30


<210>  566
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  566
tggccaggag gtcggcc                                                    17


<210>  567
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  567
ggaggccgac gagaggcc                                                   18


<210>  568
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  568
tggttcacca acccatgcaa gaccatga                                        28


<210>  569
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  569
cggcgccaca cgatgaact                                                  19


<210>  570
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  570
aaggagattg ctgcaaagca caaa                                            24


<210>  571
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  571
gcagcccagg ttctgatccg tttccatatc                                      30


<210>  572
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  572
acctgaatgt tctcaacaat gcgtg                                           25


<210>  573
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  573
agtctcccta atggcaaacc ggt                                             23


<210>  574
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  574
tgtgctcatg aacaatggcc tcaagatgga                                      30


<210>  575
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  575
acgaaaccgt gctccttgca g                                               21


<210>  576
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  576
ccacctccca cctggctacc ta                                              22


<210>  577
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  577
tttccagggc cctaagcagg atgctgag                                        28


<210>  578
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  578
atgtccagga tgaacctctt ggct                                            24


<210>  579
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  579
gttccaaggt gcgggagcac                                                 20


<210>  580
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  580
attcccagct tctggctcaa ccaccagg                                        28


<210>  581
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  581
ggtcgtggtc ccagcactca g                                               21


<210>  582
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  582
tgctggccat tgccatattt attc                                            24


<210>  583
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  583
caagggcctt tggagcagat tctgaacaca                                      30


<210>  584
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  584
aagcctccac ttccctttcc tctaa                                           25


<210>  585
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  585
gcagtcgcaa ctgtggggc                                                  19


<210>  586
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  586
ctatggatgc aggccattcg tccttccag                                       29


<210>  587
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  587
caccagaaca ccatgatcca ggtt                                            24


<210>  588
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  588
aacggcatgt ccgtggcag                                                  19


<210>  589
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  589
gccgcgcctg gccagcca                                                   18


<210>  590
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  590
cgccagtcgg cctgggt                                                    17


<210>  591
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  591
ttcgggccag agcgcg                                                     16


<210>  592
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  592
ccatagagtc ccaggatgga ggacccttcc                                      30


<210>  593
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  593
agcgggtgct ggaagagcc                                                  19


<210>  594
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  594
cgcagccgca gctccag                                                    17


<210>  595
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  595
cccagcctca gcctcagccg ca                                              22


<210>  596
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  596
gatgcggata cgggtggagc                                                 20


<210>  597
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  597
cggctccggg ttctggaag                                                  19


<210>  598
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  598
actcgcagtc gccgggctgc c                                               21


<210>  599
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  599
gttggccgcg atgccg                                                     16


<210>  600
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  600
tgcaccaacg aactgtacat gatga                                           25


<210>  601
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  601
ttggcatgca gtgccctccc agaga                                           25


<210>  602
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  602
tggctgaggt ccaagtattc ctcat                                           25


<210>  603
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  603
tccaccctga cacaggccg                                                  19


<210>  604
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  604
cggaggaagc ccaccgtgcc g                                               21


<210>  605
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  605
ctggcttctg agtttcacga acatg                                           25


<210>  606
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  606
ggtggatgat caaaccttgc cac                                             23


<210>  607
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  607
ctctccggcc aggaagttca ctgggc                                          26


<210>  608
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  608
tcagatgcaa gcagcaactt tgg                                             23


<210>  609
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  609
aaagttccga aatggaggcg g                                               21


<210>  610
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  610
gaggtggacc gcgtggacta tgacagaca                                       29


<210>  611
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  611
atctccacaa acgtgatgac tgcac                                           25


<210>  612
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  612
gtgcagctgt tgtggagatg ttgat                                           25


<210>  613
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  613
gtgtggttgg caaaatttcc aagcactgga                                      30


<210>  614
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  614
tcagcgtctg taaatgcctc tctca                                           25


<210>  615
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  615
cttccaggtg aatccaacaa gatcc                                           25


<210>  616
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  616
ggactactct ggatcaggct tcggctccg                                       29


<210>  617
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  617
tcctgatcca gagccggagc                                                 20


<210>  618
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  618
aatgaggaat cgggtcctct tgg                                             23


<210>  619
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  619
caacagtgct gacctggact gtgacccg                                        28


<210>  620
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  620
acataagagg tttgcaggga tggg                                            24


<210>  621
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  621
ggaatgccat tacactgtgc ttgg                                            24


<210>  622
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  622
tgctttgtga gtagaccaca tcccaagcca                                      30


<210>  623
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  623
gtcatggctg cagttctgtc gg                                              22


<210>  624
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  624
tcgagtgccc agttatgacc ctc                                             23


<210>  625
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  625
aaggtgatcc tcccaaactt cctggccaa                                       29


<210>  626
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  626
ttatcatctg gaacccatct ccacc                                           25


<210>  627
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  627
gttcagatgt gcaaggataa gcgg                                            24


<210>  628
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  628
cccggaacgg cactgttcac ctttatctg                                       29


<210>  629
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  629
atggtgctga cgtgtagagc gg                                              22


<210>  630
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  630
ggtgagctta gactcccggg tg                                              22


<210>  631
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  631
acatggtgga gccatcccaa cacatattcg                                      30


<210>  632
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  632
gacagcagag ttcatgaatc gagga                                           25


<210>  633
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  633
aggggatcta ccaccacact ggtc                                            24


<210>  634
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  634
aatcatgctg ttctgcttgt gggctatggc                                      30


<210>  635
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  635
atccatccca gaggctgagt cagt                                            24


<210>  636
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  636
tttaagaatg cgcttgctgc tca                                             23


<210>  637
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  637
ttgtgtccca gccacttgct ttcttggaag                                      30


<210>  638
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  638
gcaggttcat cttcctcttt gagga                                           25


<210>  639
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  639
atacctgtgg ccttgggcct c                                               21


<210>  640
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  640
tgtcctgcgt gttgaaagat gataagccca                                      30


<210>  641
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  641
ttgttgaaga caaatcgctt ttcca                                           25


<210>  642
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  642
acctctacca cgccctccca g                                               21


<210>  643
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  643
attctgcggg tgtccaagac actgagatgg                                      30


<210>  644
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  644
gcagcactga gtccagatgt ctacg                                           25


<210>  645
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  645
cctcttcatg gtggccacag c                                               21


<210>  646
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  646
atctgcatcc tgctcaacct cgtggagct                                       29


<210>  647
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  647
ccttgctgcc aggcactcg                                                  19


<210>  648
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  648
cctgctggag ggcgaggag                                                  19


<210>  649
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  649
gggctgtgaa tgtctgtgtc agcagctcc                                       29


<210>  650
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  650
gggagcctga cacgcagagg                                                 20


<210>  651
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  651
cagagacact caagatgccc ttgc                                            24


<210>  652
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  652
tagccaacca cgccaatgac accatgaa                                        28


<210>  653
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  653
acccgaccag gctgcacaat                                                 20


<210>  654
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  654
ggagctagag gctaccaggc aaaa                                            24


<210>  655
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  655
actgttgctg tccacagcca tgagccact                                       29


<210>  656
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  656
ccaactgtgc accatcactg agg                                             23


<210>  657
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  657
tgatgggttc accatccagg tg                                              22


<210>  658
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  658
gaatctcttt cgaggtgctg gccgcc                                          26


<210>  659
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  659
cacccagcaa tgcttactca gagc                                            24


<210>  660
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  660
atgtgcttgg tttcctagaa gccaa                                           25


<210>  661
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  661
ttgcagccaa tgaagagaat cggaagtgga                                      30


<210>  662
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  662
gggtaacctg tggctggtcg ac                                              22


<210>  663
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  663
tgctgggctc cattgggc                                                   18


<210>  664
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  664
cgtcggcaac aacctgctgg tgctc                                           25


<210>  665
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  665
ggaggtgagt gggagtgcgg                                                 20


<210>  666
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  666
ggaagccagt gaaggtggag ga                                              22


<210>  667
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  667
aatgatcgtg tgcggaacct gcaaagtga                                       29


<210>  668
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  668
cccgggccag gatccg                                                     16


<210>  669
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  669
gttctggacc tggagttgaa aggtg                                           25


<210>  670
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  670
cagctatcgt gaagtgcgcc acaagcaa                                        28


<210>  671
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  671
gaagcttctc tgcaaagaaa gctgg                                           25


<210>  672
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  672
agcgcagcag ctctgctgg                                                  19


<210>  673
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  673
tgctgcaaac tccagatcat tcccacactg                                      30


<210>  674
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  674
catcatcaga cagagcacga agca                                            24


<210>  675
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  675
tctgtcctcc taagaaatct gccca                                           25


<210>  676
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  676
cctgagtgcc agagtgactg gcagtgtcc                                       29


<210>  677
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  677
ggatccaggc atttgatgcc a                                               21


<210>  678
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  678
acctatgatc tgaagagcgt cctgg                                           25


<210>  679
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  679
aagctctcca aggccgtgca taaggctg                                        28


<210>  680
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  680
cctttctcgt cgatggtcag ca                                              22


<210>  681
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  681
ctgcacgcta tagcaacgtc agc                                             23


<210>  682
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  682
gcattgagga ctcattcgcc atggagaaga                                      30


<210>  683
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  683
gagtgctgcc acatggaggc t                                               21


<210>  684
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  684
agctctccaa tcacaggcag acg                                             23


<210>  685
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  685
gggcaaatat ggccaaacag attggagca                                       29


<210>  686
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  686
tccgactgta aagctgagca ttcg                                            24


<210>  687
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  687
gcagagttat tggaaaagga ggcaa                                           25


<210>  688
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  688
ttgttgtccc tcgtgaccag acacctgatg                                      30


<210>  689
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  689
acctggcaag catagaagtg acca                                            24


<210>  690
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  690
tcatcttctg tgtcattgcc ctcc                                            24


<210>  691
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  691
ggtcttcgtg ttccagctct tcaccatgga                                      30


<210>  692
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  692
cctgagagga agaaccggtt tcc                                             23


<210>  693
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  693
acatcaaggg cgagtctcta ttcca                                           25


<210>  694
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  694
ggccgcggcg gcctgga                                                    17


<210>  695
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  695
ccgcgcacgc gcaag                                                      15


<210>  696
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  696
acccagtgcc aggccgc                                                    17


<210>  697
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  697
cctccccagg ccaggaggtg catc                                            24


<210>  698
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  698
caagtgctgc cagaggccg                                                  19


<210>  699
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  699
cagagctgct ggaactacgg ctt                                             23


<210>  700
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  700
tcctgctcct cggacgagct ccctg                                           25


<210>  701
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  701
agccgccaga cttggtgagg                                                 20


<210>  702
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  702
acgtggcacc aaccatcatc c                                               21


<210>  703
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  703
ccatgtaccg tcctcggcca gcca                                            24


<210>  704
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  704
agtcgaacac caagagggtg tcg                                             23


<210>  705
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  705
ggctcattgg tggcctggag                                                 20


<210>  706
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  706
gatgcgagat ggaggctcag aaccaggag                                       29


<210>  707
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  707
gtagcgatct cctgctccag cc                                              22


<210>  708
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  708
gttcatgcag ctgcactttc caa                                             23


<210>  709
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  709
accagtcaca gcaggaggag tcgcaaaca                                       29


<210>  710
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  710
aagcagtctt gttggtttcc agca                                            24


<210>  711
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  711
acagaagagc aactgagatc gagcc                                           25


<210>  712
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  712
agagatgtgc ctcgaaccac acaaagcacc                                      30


<210>  713
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  713
gttcttgcag gaggcccgg                                                  19


<210>  714
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  714
cctggaaaat gtgcctgtga atgta                                           25


<210>  715
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  715
ccaccaccaa acatgcagct gttacagacg                                      30


<210>  716
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  716
caagccttct ggcggttcgt a                                               21


<210>  717
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  717
ctggaatgca ccccaggctc                                                 20


<210>  718
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  718
cacctgggcc aggcccgcat c                                               21


<210>  719
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  719
gcactcgttg ctgggcagc                                                  19


<210>  720
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  720
aatgggggct tgattaaagg cc                                              22


<210>  721
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  721
tttggacagg cacggatggt gacaactaca                                      30


<210>  722
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  722
aggaagcaga cagtgatggg gc                                              22


<210>  723
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  723
gacgccaagt tccggcga                                                   18


<210>  724
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  724
cgcatcaccg tttgcggaaa gacgtc                                          26


<210>  725
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  725
cccaaacacc tccttggcca                                                 20


<210>  726
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  726
ctgcgagtgg cactgctgct                                                 20


<210>  727
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  727
gctcctggta gccgctggcc gg                                              22


<210>  728
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  728
gacgctcctg ctgcgcg                                                    17


<210>  729
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  729
cgttgctgtg gacatattga ttgct                                           25


<210>  730
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  730
tcatgattct gggcttcctg ggatgctg                                        28


<210>  731
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  731
aacaacagaa gcatgcagcg actt                                            24


<210>  732
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  732
ccagcagcaa attaatcaac agcag                                           25


<210>  733
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  733
ctccagctgc agcagctgca acacatg                                         27


<210>  734
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  734
ggagaaggct gagactggtg ctg                                             23


<210>  735
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  735
gcctgtcaga gcctgccaag a                                               21


<210>  736
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  736
tcacagatgt tgtgaaggtc ctgggcctg                                       29


<210>  737
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  737
tgctggctcc tgggtggg                                                   18


<210>  738
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  738
tcaaggtatt tggtcccgga aca                                             23


<210>  739
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  739
caacttgatg cagatgtttc ccccaagcc                                       29


<210>  740
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  740
agccttctgg agctttgttt cagc                                            24


<210>  741
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  741
ctgaaacatt caccttccat gcaga                                           25


<210>  742
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  742
tgcacttgtt gagctcgtga aacacaagcc                                      30


<210>  743
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  743
agctttcagt tgctcttttg ttgcc                                           25


<210>  744
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  744
attgtcctgc tggtaattgg gctaa                                           25


<210>  745
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  745
tcccttatga acaaggagca ccttgtgcca                                      30


<210>  746
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  746
attggtgcat agtccatcgt cacag                                           25


<210>  747
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  747
gctgcacaag cagaagtcat cagac                                           25


<210>  748
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  748
cagttcagag ttcagcccgg gctgagg                                         27


<210>  749
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  749
acagcgatga tggccgtgc                                                  19


<210>  750
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  750
tgagagcgaa tgtcgttgct gag                                             23


<210>  751
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  751
aaccagattc ttggcagaag gtggcatgc                                       29


<210>  752
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  752
tttagcctgc tcttcacggg aga                                             23


<210>  753
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  753
cccaccaggc aaagagggac t                                               21


<210>  754
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  754
ggccctcagg gccctcctgg ct                                              22


<210>  755
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  755
ccaacggtgc cctgaagtcc                                                 20


<210>  756
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  756
aagcaagcat gtcatctatg ctcca                                           25


<210>  757
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  757
gcagccacaa caagtatgca ggggagtca                                       29


<210>  758
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  758
caggccttgg aagggtccac t                                               21


<210>  759
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  759
caccatgcta ggtaacaagc gactg                                           25


<210>  760
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  760
ctgctcgtgt gcctgggtgc gct                                             23


<210>  761
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  761
cgggttgtcc ggcttgga                                                   18


<210>  762
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  762
tcaacatctt cgcaatccat caca                                            24


<210>  763
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  763
ccctcagtct ggccagaccc tgaggtct                                        28


<210>  764
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  764
tgcccgatgc agttcctgg                                                  19


<210>  765
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  765
caaggaactc gatcgtatca ttgca                                           25


<210>  766
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  766
ccacatcctg ctcaagacgc ttctaccagc                                      30


<210>  767
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  767
aataggctgc acggagtcca gg                                              22


<210>  768
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  768
gagatcatga aaggcaacca tgtga                                           25


<210>  769
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  769
tacaaggagc catcactgca cgatctcacg                                      30


<210>  770
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  770
ggtcccgctt ccagatcgg                                                  19


<210>  771
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  771
aagattggat caggaccatg tgagg                                           25


<210>  772
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  772
ggattatggt ggcccacttg tttgtgagca                                      30


<210>  773
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  773
accaggaaca atgacaccaa gaacc                                           25


<210>  774
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  774
tggacattct tttggtggag caac                                            24


<210>  775
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  775
gatgtggtat tgccctggat gcatggatgt                                      30


<210>  776
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  776
gaggggctga ggaattctgg aatat                                           25


<210>  777
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  777
gacctgccca cccaggagc                                                  19


<210>  778
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  778
agcactgggg accacctgct acgcct                                          26


<210>  779
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  779
aagaactcct ctggttcaat gctgc                                           25


<210>  780
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  780
gaatggtgca gtagaaatcg ctcg                                            24


<210>  781
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  781
gctcgcgggg acagtacttt ggagagctt                                       29


<210>  782
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  782
ggcgtgggca gaagctgc                                                   18


<210>  783
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  783
gagtggccta cagatggcgc tag                                             23


<210>  784
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  784
acggactcct tcctccctat gcttcttgcc                                      30


<210>  785
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  785
atacggctcg tgctgcgtct c                                               21


<210>  786
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  786
gttcaagtcc aatgaaggga acagc                                           25


<210>  787
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  787
gctagagggt tccaggtccc atacgtgaca                                      30


<210>  788
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  788
agagcctgcc atctcgaact atgtc                                           25


<210>  789
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  789
tcaccatacc taagcagcaa cgct                                            24


<210>  790
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  790
atgggaaagg aatcatagcc catgccacc                                       29


<210>  791
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  791
tcacttggtt tatctggcat tgtgg                                           25


<210>  792
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  792
agttgctgtg gaggaaattc gtgat                                           25


<210>  793
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  793
ataacagaaa gtccttccgc cttcgtcgca                                      30


<210>  794
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  794
gtttgttgaa acccagcaag aggtc                                           25


<210>  795
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  795
atggaagctt gaaggattcc acaaa                                           25


<210>  796
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  796
tccaacccag gaggaaagac agatgaaccc                                      30


<210>  797
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  797
tgatggcttc caaataggct tctgt                                           25


<210>  798
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  798
cgccagctgc tacatcctga aa                                              22


<210>  799
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  799
tcccctgttc aacatagatg cctgtggagg                                      30


<210>  800
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  800
tcgtatgtgt cactccatgc ctca                                            24


<210>  801
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  801
gaagcgctac gcctacaagt tcg                                             23


<210>  802
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  802
cttccacggg atcgcccagg cc                                              22


<210>  803
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  803
ccatgtacgg gaggtctgag gg                                              22


<210>  804
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  804
tgttctgaga atgggactgt cgatg                                           25


<210>  805
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  805
tctggcaaaa aacatcacac ctcaaaggca                                      30


<210>  806
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  806
tctgtgcagc agcaattcat cctat                                           25


<210>  807
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  807
ccatttgagg tagaaaatgc cctga                                           25


<210>  808
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  808
tcagttgcag agtcagctgt tgtcagcagc                                      30


<210>  809
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  809
acctctcctc tgatggggtc tgg                                             23


<210>  810
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  810
gccataacaa tctcctctgc tctgc                                           25


<210>  811
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  811
gcaggaacag tgtgggtgaa ttgctatggc                                      30


<210>  812
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  812
ggggcactgg gcacttacca                                                 20


<210>  813
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  813
tccccgggaa acagagtttc taga                                            24


<210>  814
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  814
cgccaccact actcaaagaa gtggcacaga                                      30


<210>  815
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  815
ggacaggcta gtgcctattt tgtgg                                           25


<210>  816
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  816
ttcctggctc tcgtttgctt tgt                                             23


<210>  817
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  817
ttcattgctt ccggaaggcc attcatga                                        28


<210>  818
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  818
cagccgattc tgaacctttc gag                                             23


<210>  819
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  819
tccaggcaac caaagaggtg aac                                             23


<210>  820
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  820
ttgcaccagg gaagagacaa gccgga                                          26


<210>  821
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  821
gcggtaggaa tccttctcca tcag                                            24


<210>  822
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  822
cagaggtagc caagaaggaa ccaga                                           25


<210>  823
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  823
agcagagaag aaggaggcag caccggag                                        28


<210>  824
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  824
aggcttcttg gccttctcct cc                                              22


<210>  825
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  825
tggcgtcaga ggacaatttc aaac                                            24


<210>  826
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  826
tccgtggtgg tcacatccta ccatgtcaag                                      30


<210>  827
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  827
tctgcagcaa caatgagctt catg                                            24


<210>  828
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  828
catcatgatc aaccagtgaa gccc                                            24


<210>  829
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  829
gagccaagca ccttcgggtt gcagc                                           25


<210>  830
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  830
ggtactggaa ccaggtgagg tcgt                                            24


<210>  831
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  831
gccctgacca ttgcaggatt aaa                                             23


<210>  832
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  832
cgcttcacaa gaagacggga tcagaagcaa                                      30


<210>  833
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  833
ttcctccttt gctgccttga tgta                                            24


<210>  834
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  834
ttccaggata ttcagaggat gccat                                           25


<210>  835
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  835
gcgaggatcc atggtgttcc agcctctt                                        28


<210>  836
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  836
ttggctttct ctgcatccca gtt                                             23


<210>  837
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  837
gtggtgatga tgaagacggt gaaga                                           25


<210>  838
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  838
ccaccaagaa ggaaaagcag acggcga                                         27


<210>  839
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  839
agtgaggtgg tgcattagct gacaa                                           25


<210>  840
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  840
cacaggctca gctggtgcag tt                                              22


<210>  841
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  841
tgctcgccat cacgcacacc atga                                            24


<210>  842
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  842
acacggtttc acgacggcg                                                  19


<210>  843
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  843
tggcgatacc aggaattcag ca                                              22


<210>  844
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  844
cagagcatgc ctcgagaagg gcatgg                                          26


<210>  845
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  845
ctgtgaagac ctcctccgta gatgg                                           25


<210>  846
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  846
cgcgtcgggg ctgcc                                                      15


<210>  847
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  847
aggcgtcgcg ctggcgcg                                                   18


<210>  848
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  848
aagcgcttct cgcggttctg                                                 20


<210>  849
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  849
tcatgttagc agccagtgtt ggaat                                           25


<210>  850
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  850
tgtgcagata aatcacagcc aggagggca                                       29


<210>  851
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  851
ccgagggaat tctgtatcct gtcc                                            24


<210>  852
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  852
gttcagcaac cagggagtct gtacc                                           25


<210>  853
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  853
ctgctgcaaa gcagtcaatg accttggga                                       29


<210>  854
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  854
cctccagttt gcattcaatc tcca                                            24


<210>  855
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  855
ccaaatccca ctcaaacctt tcaac                                           25


<210>  856
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  856
aatgagcacg ctttcctacc gcccctc                                         27


<210>  857
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  857
tgcaggcttc ttggtggatg ag                                              22


<210>  858
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  858
caaggtgggt tcctgccagg                                                 20


<210>  859
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  859
gatgctgact gctttgagaa ggccagcaag                                      30


<210>  860
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  860
aatcctctca ggtgccagct tga                                             23


<210>  861
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  861
aggaactgag gaggctcttc cttgt                                           25


<210>  862
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  862
tgatgtggct cctgacctac gttggcg                                         27


<210>  863
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  863
ccacagccat gagcagcagg                                                 20


<210>  864
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  864
gaactgccca agctggagaa gc                                              22


<210>  865
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  865
tgccacggcg gagcgcgtc                                                  19


<210>  866
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  866
tcccgcatgg cgttctcc                                                   18


<210>  867
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  867
tcttcagtgg gaggtccaaa tgc                                             23


<210>  868
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  868
gccagaggag tgctcagcaa gcaggaagt                                       29


<210>  869
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  869
tggtacggtg accagtctca cagtc                                           25


<210>  870
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  870
ggcaattata acacagggct gcaa                                            24


<210>  871
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  871
agcagggagt ggaatggaaa ccatacaggc                                      30


<210>  872
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  872
tcttgtccac catggaggat ttca                                            24


<210>  873
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  873
caattggatt tctgctcgga ttca                                            24


<210>  874
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  874
tgactgttgg cccacccatt gcagg                                           25


<210>  875
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  875
cacatcatag gagcccagtt tgtca                                           25


<210>  876
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  876
cctcgccatg aagctgctga t                                               21


<210>  877
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  877
tgctggcggc cctcctcctg c                                               21


<210>  878
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  878
tcaaccatgt cctccaggag tttg                                            24


<210>  879
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  879
cctcaagacc ctggctgact ttg                                             23


<210>  880
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  880
gtgcccttcc gcacggtgtc cg                                              22


<210>  881
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  881
tgctgcatct tgatggactc cag                                             23


<210>  882
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  882
ggcatttttc aggtaaccct cactg                                           25


<210>  883
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  883
tgctctttgc tcagcatcgc tacatctccc                                      30


<210>  884
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  884
ctgcaatgtc actgccaatt agca                                            24


<210>  885
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  885
gctgcggggt ggccg                                                      15


<210>  886
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  886
tgatcaccac ctgttacgga gggcgg                                          26


<210>  887
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  887
ctcggccacc ctgcggt                                                    17


<210>  888
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  888
agccgagcca catcgct                                                    17


<210>  889
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  889
gtgaccaggc gcccaatac                                                  19


<210>  890
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  890
caaatccgtt gactccgacc ttcacctt                                        28


<210>  891
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  891
cagggcaaca ucuacaagct t                                               21


<210>  892
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  892
gcaaguguac gacgcgcact t                                               21


<210>  893
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  893
ccgcuugcug ucugcccuct t                                               21


<210>  894
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  894
caucugggca guuguaccat t                                               21


<210>  895
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  895
cuacgcacuc cuuugacaat t                                               21


<210>  896
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  896
aguguggauc ugcagccaut t                                               21


<210>  897
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  897
guuccugacg guguuccugt t                                               21


<210>  898
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  898
uugcgggaau ucucuuugct t                                               21


<210>  899
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  899
ggaaguggua cugcuggact t                                               21


<210>  900
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  900
cuuccagaag cgccuguuct t                                               21


<210>  901
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  901
gagccccgua ugcacugugt t                                               21


<210>  902
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  902
cuacaccuuc accguggagt t                                               21


<210>  903
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  903
gcuuguagau guugcccugt t                                               21


<210>  904
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  904
gugcgcgucg uacacuugct t                                               21


<210>  905
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  905
gagggcagac agcaagcggt t                                               21


<210>  906
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  906
ugguacaacu gcccagaugt t                                               21


<210>  907
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  907
uugucaaagg agugcguagt t                                               21


<210>  908
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  908
auggcugcag auccacacut t                                               21


<210>  909
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  909
caggaacacc gucaggaact t                                               21


<210>  910
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  910
gcaaagagaa uucccgcaat t                                               21


<210>  911
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  911
guccagcagu accacuucct t                                               21


<210>  912
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Oligonucleotide.

<400>  912
gaacaggcgc uucuggaagt t                                               21


