                         SEQUENCE LISTING

<110>  sanofi-aventis US LLC
       ADEDOYIN, Adedayo
       ANGELASTRO, Michael R
       BICK, Julie Ann
       CAIRNS, Jennifer
       HUANG, Yongqing
       LIANG, Guyan
       LIM, Heng-Keang
 
<120>  METHOD FOR DETERMINING THE STABILITY OF ORGANIC METHYLENEAMINES 
       IN THE PRESENCE OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE

<130>  US2005/172 WO PCT

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Gln Lys Thr Ile Leu Val Leu Leu Ile Leu Ala Val Ile Thr 
1               5                   10                  15      


Ile Phe Ala Leu Val Cys Val Leu Leu Val Gly Arg Gly Gly Asp Gly 
            20                  25                  30          


Gly Glu Pro Ser Gln Leu Pro His Cys Pro Ser Val Ser Pro Ser Ala 
        35                  40                  45              


Gln Pro Trp Thr His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser 
    50                  55                  60                  


Arg Glu Glu Leu Thr Ala Val Met Arg Phe Leu Thr Gln Arg Leu Gly 
65                  70                  75                  80  


Pro Gly Leu Val Asp Ala Ala Gln Ala Arg Pro Ser Asp Asn Cys Val 
                85                  90                  95      


Phe Ser Val Glu Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His 
            100                 105                 110         


Leu Asp Arg Gly Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val 
        115                 120                 125             


Phe Phe Gly Arg Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly 
    130                 135                 140                 


Pro Leu Pro His Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His 
145                 150                 155                 160 


Gly Gly Pro Leu Pro Tyr His Arg Arg Pro Val Leu Phe Gln Glu Tyr 
                165                 170                 175     


Leu Asp Ile Asp Gln Met Ile Phe Asn Arg Glu Leu Pro Gln Ala Ser 
            180                 185                 190         


Gly Leu Leu His His Cys Cys Phe Tyr Lys His Arg Gly Arg Asn Leu 
        195                 200                 205             


Val Thr Met Thr Thr Ala Pro Arg Gly Leu Gln Ser Gly Asp Arg Ala 
    210                 215                 220                 


Thr Trp Phe Gly Leu Tyr Tyr Asn Ile Ser Gly Ala Gly Phe Phe Leu 
225                 230                 235                 240 


His His Val Gly Leu Glu Leu Leu Val Asn His Lys Ala Leu Asp Pro 
                245                 250                 255     


Ala Arg Trp Thr Ile Gln Lys Val Phe Tyr Gln Gly Arg Tyr Tyr Asp 
            260                 265                 270         


Ser Leu Ala Gln Leu Glu Ala Gln Phe Glu Ala Gly Leu Val Asn Val 
        275                 280                 285             


Val Leu Ile Pro Asp Asn Gly Thr Gly Gly Ser Trp Ser Leu Lys Ser 
    290                 295                 300                 


Pro Val Pro Pro Gly Pro Ala Pro Pro Leu Gln Phe Tyr Pro Gln Gly 
305                 310                 315                 320 


Pro Arg Phe Ser Val Gln Gly Ser Arg Val Ala Ser Ser Leu Trp Thr 
                325                 330                 335     


Phe Ser Phe Gly Leu Gly Ala Phe Ser Gly Pro Arg Ile Phe Asp Val 
            340                 345                 350         


Arg Phe Gln Gly Glu Arg Leu Val Tyr Glu Ile Ser Leu Gln Glu Ala 
        355                 360                 365             


Leu Ala Ile Tyr Gly Gly Asn Ser Pro Ala Ala Met Thr Thr Arg Tyr 
    370                 375                 380                 


Val Asp Gly Gly Phe Gly Met Gly Lys Tyr Thr Thr Pro Leu Thr Arg 
385                 390                 395                 400 


Gly Val Asp Cys Pro Tyr Leu Ala Thr Tyr Val Asp Trp His Phe Leu 
                405                 410                 415     


Leu Glu Ser Gln Ala Pro Lys Thr Ile Arg Asp Ala Phe Cys Val Phe 
            420                 425                 430         


Glu Gln Asn Gln Gly Leu Pro Leu Arg Arg His His Ser Asp Leu Tyr 
        435                 440                 445             


Ser His Tyr Phe Gly Gly Leu Ala Glu Thr Val Leu Val Val Arg Ser 
    450                 455                 460                 


Met Ser Thr Leu Leu Asn Tyr Asp Tyr Val Trp Asp Thr Val Phe His 
465                 470                 475                 480 


Pro Ser Gly Ala Ile Glu Ile Arg Phe Tyr Ala Thr Gly Tyr Ile Ser 
                485                 490                 495     


Ser Ala Phe Leu Phe Gly Ala Thr Gly Lys Tyr Gly Asn Gln Val Ser 
            500                 505                 510         


Glu His Thr Leu Gly Thr Val His Thr His Ser Ala His Phe Lys Val 
        515                 520                 525             


Asp Leu Asp Val Ala Gly Leu Glu Asn Trp Val Trp Ala Glu Asp Met 
    530                 535                 540                 


Val Phe Val Pro Met Ala Val Pro Trp Ser Pro Glu His Gln Leu Gln 
545                 550                 555                 560 


Arg Leu Gln Val Thr Arg Lys Leu Leu Glu Met Glu Glu Gln Ala Ala 
                565                 570                 575     


Phe Leu Val Gly Ser Ala Thr Pro Arg Tyr Leu Tyr Leu Ala Ser Asn 
            580                 585                 590         


His Ser Asn Lys Trp Gly His Pro Arg Gly Tyr Arg Ile Gln Met Leu 
        595                 600                 605             


Ser Phe Ala Gly Glu Pro Leu Pro Gln Asn Ser Ser Met Ala Arg Gly 
    610                 615                 620                 


Phe Ser Trp Glu Arg Tyr Gln Leu Ala Val Thr Gln Arg Lys Glu Glu 
625                 630                 635                 640 


Glu Pro Ser Ser Ser Ser Val Phe Asn Gln Asn Asp Pro Trp Ala Pro 
                645                 650                 655     


Thr Val Asp Phe Ser Asp Phe Ile Asn Asn Glu Thr Ile Ala Gly Lys 
            660                 665                 670         


Asp Leu Val Ala Trp Val Thr Ala Gly Phe Leu His Ile Pro His Ala 
        675                 680                 685             


Glu Asp Ile Pro Asn Thr Val Thr Val Gly Asn Gly Val Gly Phe Phe 
    690                 695                 700                 


Leu Arg Pro Tyr Asn Phe Phe Asp Glu Asp Pro Ser Phe Tyr Ser Ala 
705                 710                 715                 720 


Asp Ser Ile Tyr Phe Arg Gly Asp Gln Asp Ala Gly Ala Cys Glu Val 
                725                 730                 735     


Asn Pro Leu Ala Cys Leu Pro Gln Ala Ala Ala Cys Ala Pro Asp Leu 
            740                 745                 750         


Pro Ala Phe Ser His Gly Gly Phe Ser His Asn 
        755                 760             


<210>  2
<211>  2292
<212>  DNA
<213>  Homo sapiens

<400>  2
atgaaccaga agacaatcct cgtgctcctc attctggccg tcatcaccat ctttgccttg     60

gtttgtgtcc tgctggtggg caggggtgga gatgggggtg aacccagcca gcttccccat    120

tgcccctctg tatctcccag tgcccagcct tggacacacc ctggccagag ccagctgttt    180

gcagacctga gccgagagga gctgacggct gtgatgcgct ttctgaccca gcggctgggg    240

ccagggctgg tggatgcagc ccaggcccgg ccctcggaca actgtgtctt ctcagtggag    300

ttgcagctgc ctcccaaggc tgcagccctg gctcacttgg acagggggag ccccccacct    360

gcccgggagg cactggccat cgtcttcttt ggcaggcaac cccagcccaa cgtgagtgag    420

ctggtggtgg ggccactgcc tcacccctcc tacatgcggg acgtgactgt ggagcgtcat    480

ggaggccccc tgccctatca ccgacgcccc gtgctgttcc aagagtacct ggacatagac    540

cagatgatct tcaacagaga gctgccccag gcttctgggc ttctccacca ctgttgcttc    600

tacaagcacc ggggacggaa cctggtgaca atgaccacgg ctccccgtgg tctgcaatca    660

ggggaccggg ccacctggtt tggcctctac tacaacatct cgggcgctgg gttcttcctg    720

caccacgtgg gcttggagct gctagtgaac cacaaggccc ttgaccctgc ccgctggact    780

atccagaagg tgttctatca aggccgctac tacgacagcc tggcccagct ggaggcccag    840

tttgaggccg gcctggtgaa tgtggtgctg atcccagaca atggcacagg tgggtcctgg    900

tccctgaagt cccctgtgcc cccgggtcca gctccccctc tacagttcta tccccaaggc    960

ccccgcttca gtgtccaggg aagtcgagtg gcctcctcac tgtggacttt ctcctttggc   1020

ctcggagcat tcagtggccc aaggatcttt gacgttcgct tccaaggaga aagactagtt   1080

tatgagataa gcctccaaga ggccttggcc atctatggtg gaaattcccc agcagcaatg   1140

acgacccgct atgtggatgg aggctttggc atgggcaagt acaccacgcc cctgacccgt   1200

ggggtggact gcccctactt ggccacctac gtggactggc acttcctttt ggagtcccag   1260

gcccccaaga caatacgtga tgccttttgt gtgtttgaac agaaccaggg cctccccctg   1320

cggcgacacc actcagatct ctactcgcac tactttgggg gtcttgcgga aacggtgctg   1380

gtcgtcagat ctatgtccac cttgctcaac tatgactatg tgtgggatac ggtcttccac   1440

cccagtgggg ccatagaaat acgattctat gccacgggct acatcagctc ggcattcctc   1500

tttggtgcta ctgggaagta cgggaaccaa gtgtcagagc acaccctggg cacggtccac   1560

acccacagcg cccacttcaa ggtggatctg gatgtagcag gactggagaa ctgggtctgg   1620

gccgaggata tggtctttgt ccccatggct gtgccctgga gccctgagca ccagctgcag   1680

aggctgcagg tgacccggaa gctgctggag atggaggagc aggccgcctt cctcgtggga   1740

agcgccaccc ctcgctacct gtacctggcc agcaaccaca gcaacaagtg gggtcacccc   1800

cggggctacc gcatccagat gctcagcttt gctggagagc cgctgcccca aaacagctcc   1860

atggcgagag gcttcagctg ggagaggtac cagctggctg tgacccagcg gaaggaggag   1920

gagcccagta gcagcagcgt tttcaatcag aatgaccctt gggcccccac tgtggatttc   1980

agtgacttca tcaacaatga gaccattgct ggaaaggatt tggtggcctg ggtgacagct   2040

ggttttctgc atatcccaca tgcagaggac attcctaaca cagtgactgt ggggaacggc   2100

gtgggcttct tcctccgacc ctataacttc tttgacgaag acccctcctt ctactctgcc   2160

gactccatct acttccgagg ggaccaggat gctggggcct gcgaggtcaa ccccctagct   2220

tgcctgcccc aggctgctgc ctgtgccccc gacctccctg ccttctccca cgggggcttc   2280

tctcacaact ag                                                       2292


<210>  3
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  initial cloning primer - forward

<400>  3
aaaagcaggc ttaggaatga accagaagac aatcctc                              37


<210>  4
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  initial cloning primer - reverse

<400>  4
caagaaagct gggtcctagt tgtgagagaa gcccc                                35


<210>  5
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  universal primer - forward

<400>  5
ggggacaagt ttgtacaaaa aagcaggctt agga                                 34


<210>  6
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  universal primer - reverse

<400>  6
ggggaccact ttgtacaaga aagctgggtc                                      30


<210>  7
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer sequence for cloning untagged full-length SSAO

<400>  7
aaaagcaggc ttaggaatga accagaagac aatcctc                              37


<210>  8
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer sequence for cloning untagged full-length SSAO

<400>  8
caagaaagct gggtcctagt tgtgagagaa gcccccgtgg                           40


<210>  9
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer sequence for cloning full-length SSAO with 
       C-terminal 6xHIS tag

<400>  9
aaaagcaggc ttaggaatga accagaagac aatcctc                              37


<210>  10
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer sequences for cloning full-length SSAO with 
       C-terminal 6xHIS tag

<400>  10
caagaaagct gggtcctaat ggtgatggtg atggtggttg tgagagaagc ccccgtgg       58


<210>  11
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer sequences for cloning N-terminal truncated 
       untagged SSAO

<400>  11
aaaagcaggc ttaggaatgg gcaggggtgg agatgggggt g                         41


<210>  12
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer sequences for cloning N-terminal truncated 
       untagged SSAO

<400>  12
caagaaagct gggtcctagt tgtgagagaa gcccc                                35


<210>  13
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer sequences for cloning N-terminal truncated  
       C-terminal 6xHIS tag SSAO

<400>  13
aaaagcaggc ttaggaatgg gcaggggtgg agatgggggt g                         41


<210>  14
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer sequences for cloning N-terminal truncated 
       C-terminal 6xHIS tag SSAO

<400>  14
caagaaagct gggtcctaat ggtgatggtg atggtggttg tgagagaagc ccccgtgg       58


<210>  15
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer sequences for cloning catalytic domain of untagged
       SSAO

<400>  15
aaaagcaggc ttaggaatga ccacggctcc ccgtggtc                             38


<210>  16
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer sequences for cloning catalytic domain of untagged
       SSAO

<400>  16
caagaaagct gggtcctagt tgtgagagaa gcccc                                35


<210>  17
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer sequences for cloning catalytic domain of SSAO 
       with C-terminal 6xHIS tag

<400>  17
aaaagcaggc ttaggaatga ccacggctcc ccgtggtc                             38


<210>  18
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer sequences for cloning catalytic domain of SSAO 
       with C-terminal 6xHIS tag

<400>  18
caagaaagct gggtcctaat ggtgatggtg atggtggttg tgagagaagc ccccgtgg       58


