                               SEQUENCE LISTING                               

<110> THE GENERAL HOSPITAL CORPORATION

<120> METHODS OF TREATING ITCH

<130> 030258-059011 

<140>
<141>

<150> 60/878,302
<151> 2007-01-03

<160> 33                            

<170> PatentIn Ver. 3.3


<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Tyr Pro Gly Lys Phe                                          
  1               5    


<210> 2
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 2
tggggcgcca gctggggytt cgagggytay                                  30    


<210> 3
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Asn Ser Trp Gly Ala Ser Trp Gly Phe Glu Gly Tyr Val Arg          
  1               5                  10                


<210> 4
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 4
aggacaaatt taagcattgc tgcattatct acc                              33    


<210> 5
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
gataacttgc cggaatctgt tgattggag                                   29    


<210> 6
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Asp Asn Leu Pro Glu Ser Val Asp Trp Arg Asn Glu Gly Ala Val Leu  
  1               5                  10                  15    

Pro Cys Lys Ser                                                  
             20


<210> 7
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
cacgtggcgg agcgacgagg aggtgatgtc                                  30    


<210> 8
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
aggacaaatt taagcattgc tgcattatct acc                              33    


<210> 9
<211> 11
<212> PRT
<213> Mucuna pruriens

<400> 9
Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Ser                      
  1               5                  10    


<210> 10
<211> 11
<212> PRT
<213> Carica papaya

<400> 10
Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Ser                      
  1               5                  10    


<210> 11
<211> 11
<212> PRT
<213> Ananas comosus

<400> 11
Gln Asn Pro Cys Gly Ser Cys Trp Ala Phe Ser                      
  1               5                  10    


<210> 12
<211> 8
<212> PRT
<213> Ficus sp.

<400> 12
Gln Gly Gln Cys Gly Ser Cys Trp                                  
  1               5            


<210> 13
<211> 11
<212> PRT
<213> Arabidopsis sp.

<400> 13
Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Ser                      
  1               5                  10    


<210> 14
<211> 11
<212> PRT
<213> Pisum sativum

<400> 14
Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Ser                      
  1               5                  10    


<210> 15
<211> 11
<212> PRT
<213> Oryza sativa

<400> 15
Gln Gly Gln Cys Gly Cys Cys Trp Ala Phe Ser                      
  1               5                  10    


<210> 16
<211> 11
<212> PRT
<213> Brassica sp.

<400> 16
Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Ser                      
  1               5                  10    


<210> 17
<211> 11
<212> PRT
<213> Phaseolus vulgaris

<400> 17
Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly                      
  1               5                  10    


<210> 18
<211> 11
<212> PRT
<213> Actinidia deliciosa

<400> 18
Gln Gly Glu Cys Gly Gly Cys Trp Ala Phe Ser                      
  1               5                  10    


<210> 19
<211> 11
<212> PRT
<213> Zingiber officinale

<400> 19
Gln Gly Arg Cys Gly Ser Cys Trp Ala Phe Ala                      
  1               5                  10    


<210> 20
<211> 11
<212> PRT
<213> Homo sapiens

<400> 20
Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly                      
  1               5                  10    


<210> 21
<211> 11
<212> PRT
<213> Homo sapiens

<400> 21
Gln Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser                      
  1               5                  10    


<210> 22
<211> 11
<212> PRT
<213> Dermatophagoides sp.

<400> 22
Gln Gly Gly Cys Gly Ser Cys Trp Ala Phe Ser                      
  1               5                  10    


<210> 23
<211> 12
<212> PRT
<213> Homo sapiens

<400> 23
Lys Pro Lys Val Ile Ile Ile Gln Ala Cys Arg Gly                  
  1               5                  10        


<210> 24
<211> 12
<212> PRT
<213> Homo sapiens

<400> 24
Lys Pro Lys Leu Phe Ile Ile Gln Ala Cys Arg Gly                  
  1               5                  10        


<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Ser Gly Arg Arg Tyr Gly His Ala Leu Arg                          
  1               5                  10


<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Ala Pro Gly Lys Phe                                              
  1               5


<210> 27
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Ser Leu Ile Gly Arg Leu                                          
  1               5    


<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Gly Tyr Pro Gly Lys Phe                                          
  1               5    


<210> 29
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Gly Tyr Pro Gly Lys Phe                                          
  1               5    


<210> 30
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Ala Tyr Pro Gly Lys Phe                                          
  1               5    


<210> 31
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Phe Ser Leu Leu Arg Tyr                                          
  1               5    


<210> 32
<211> 1585
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      construct

<220> 
<221> CDS
<222> (26)..(1291)

<400> 32
cacgtggcgg agcgacgagg aggtg atg tcg ttg tac gaa cag tgg ctg gtg   52    
                            Met Ser Leu Tyr Glu Gln Trp Leu Val
                              1               5                

aag cat gga aag gcg tac aac gct ctc ggg gag aag gac aag agg ttc   100   
Lys His Gly Lys Ala Tyr Asn Ala Leu Gly Glu Lys Asp Lys Arg Phe
 10                  15                  20                  25

gac atc ttc aaa gac aac ctg cgc ttc atc gac gac cac aac gcc gac   148   
Asp Ile Phe Lys Asp Asn Leu Arg Phe Ile Asp Asp His Asn Ala Asp
                 30                  35                  40    

aac cga acc tac aag ctc ggt ctc aac cgc ttc gcg gat ctc acc aac   196   
Asn Arg Thr Tyr Lys Leu Gly Leu Asn Arg Phe Ala Asp Leu Thr Asn
             45                  50                  55        

gaa gag tac aga gcc agg tac ttg gga acc agg atc gat ccg aac cgg   244   
Glu Glu Tyr Arg Ala Arg Tyr Leu Gly Thr Arg Ile Asp Pro Asn Arg
         60                  65                  70            

agg ttc gtt aag acc aag acc cag agc aac cgt tac gcg cca cgt gtc   292   
Arg Phe Val Lys Thr Lys Thr Gln Ser Asn Arg Tyr Ala Pro Arg Val
     75                  80                  85                

ggg gac aat cta ccg gaa tcc gtt gat tgg aga aac gag agt gct gtt   340   
Gly Asp Asn Leu Pro Glu Ser Val Asp Trp Arg Asn Glu Ser Ala Val
 90                  95                 100                 105

ctc cca gtc aaa gac caa gga aac tgt ggg agc tgt tgg gca ttc tca   388   
Leu Pro Val Lys Asp Gln Gly Asn Cys Gly Ser Cys Trp Ala Phe Ser
                110                 115                 120    

aca att ggt gcg gtg gaa gga ata aac aag ata gta aca ggc gat cta   436   
Thr Ile Gly Ala Val Glu Gly Ile Asn Lys Ile Val Thr Gly Asp Leu
            125                 130                 135        

att tca tta tca gaa caa gag tta gtg gat tgt gat aca tca tat aat   484   
Ile Ser Leu Ser Glu Gln Glu Leu Val Asp Cys Asp Thr Ser Tyr Asn
        140                 145                 150            

caa gga tgc aat gga gga ctc atg gac tat gcc tat gaa ttc atc atc   532   
Gln Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Tyr Glu Phe Ile Ile
    155                 160                 165                

aac aat gga ggc att gat tcc gag gag gat tac cct tac cgt gcc gtt   580   
Asn Asn Gly Gly Ile Asp Ser Glu Glu Asp Tyr Pro Tyr Arg Ala Val
170                 175                 180                 185

gat ggt act tgt gac caa tat agg aaa aat gct aaa gtt gtt acc att   628   
Asp Gly Thr Cys Asp Gln Tyr Arg Lys Asn Ala Lys Val Val Thr Ile
                190                 195                 200    

gat tcc tac gaa gat gtt cct gcc aac gac gag cta gcc ttg aaa aag   676   
Asp Ser Tyr Glu Asp Val Pro Ala Asn Asp Glu Leu Ala Leu Lys Lys
            205                 210                 215        

gct gtt gca aat cag cct gtg agc gta gct att gaa gga gga ggc agg   724   
Ala Val Ala Asn Gln Pro Val Ser Val Ala Ile Glu Gly Gly Gly Arg
        220                 225                 230            

gaa ttt caa tta tat gtt tct ggt gta ttt act ggg aga tgt ggg aca   772   
Glu Phe Gln Leu Tyr Val Ser Gly Val Phe Thr Gly Arg Cys Gly Thr
    235                 240                 245                

gca cta gat cat ggt gtt gtg gct gtt ggg tat ggt tca gtt aaa ggt   820   
Ala Leu Asp His Gly Val Val Ala Val Gly Tyr Gly Ser Val Lys Gly
250                 255                 260                 265

cat gat tat tgg att gta agg aat tca tgg ggt gct agc tgg gga gag   868   
His Asp Tyr Trp Ile Val Arg Asn Ser Trp Gly Ala Ser Trp Gly Glu
                270                 275                 280    

gag ggc tat gtg aga tta gag aga aat ctg gct aag agc aga tca gga   916   
Glu Gly Tyr Val Arg Leu Glu Arg Asn Leu Ala Lys Ser Arg Ser Gly
            285                 290                 295        

aag tgt gga att gca att gag cca tct tat ccc atc aag aat ggt gca   964   
Lys Cys Gly Ile Ala Ile Glu Pro Ser Tyr Pro Ile Lys Asn Gly Ala
        300                 305                 310            

aat ccc ccc aat cct gga cca tca cct cct tca cca gtg aag cca cca   1012  
Asn Pro Pro Asn Pro Gly Pro Ser Pro Pro Ser Pro Val Lys Pro Pro
    315                 320                 325                

aat gtt tgt gac aac tcc tac agc tgc tct gat agt gct act tgt tgc   1060  
Asn Val Cys Asp Asn Ser Tyr Ser Cys Ser Asp Ser Ala Thr Cys Cys
330                 335                 340                 345

tgt att ttc gag ttt caa aaa tat tgc atg gtg tgg ggt tgc tgt cct   1108  
Cys Ile Phe Glu Phe Gln Lys Tyr Cys Met Val Trp Gly Cys Cys Pro
                350                 355                 360    

cta gag gct gct acc tgc tgt gac gac cat tac agt tgc tgc cct cat   1156  
Leu Glu Ala Ala Thr Cys Cys Asp Asp His Tyr Ser Cys Cys Pro His
            365                 370                 375        

gaa tat ccc atc tgc aac gtt cgt gct gga act tgt ttg aag ggc aag   1204  
Glu Tyr Pro Ile Cys Asn Val Arg Ala Gly Thr Cys Leu Lys Gly Lys
        380                 385                 390            

aac aac cca ttt gga gtg aag gca ttg agg cgt act cca gct aaa ccc   1252  
Asn Asn Pro Phe Gly Val Lys Ala Leu Arg Arg Thr Pro Ala Lys Pro
    395                 400                 405                

cat tgg gcc ttt gga ggt aag aac aag gtg aac agt gct taagaagtta    1301  
His Trp Ala Phe Gly Gly Lys Asn Lys Val Asn Ser Ala           
410                 415                 420                   

aagggaacgt gtacgtgcag aaggagtcga tgaaggacta aaaacactag ctgagctgat 1361  

acacttcacg taatcctgta cgtagcatgc agatcttaca gccaatttat tatgatacaa 1421  

acatattctg tatcaaattt cgtcatacat tggctctgta cataggatta tattaattat 1481  

gcactgtatt tgtattcaaa ttccaattgc cgaacatatt tcattgctgt tattttccaa 1541  

cttcggtaga taatgcagca atgcttaaat ttgtccttta ttca                  1585  


<210> 33
<211> 422
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 33
Met Ser Leu Tyr Glu Gln Trp Leu Val Lys His Gly Lys Ala Tyr Asn  
  1               5                  10                  15      

Ala Leu Gly Glu Lys Asp Lys Arg Phe Asp Ile Phe Lys Asp Asn Leu  
             20                  25                  30          

Arg Phe Ile Asp Asp His Asn Ala Asp Asn Arg Thr Tyr Lys Leu Gly  
         35                  40                  45              

Leu Asn Arg Phe Ala Asp Leu Thr Asn Glu Glu Tyr Arg Ala Arg Tyr  
     50                  55                  60                  

Leu Gly Thr Arg Ile Asp Pro Asn Arg Arg Phe Val Lys Thr Lys Thr  
 65                  70                  75                  80  

Gln Ser Asn Arg Tyr Ala Pro Arg Val Gly Asp Asn Leu Pro Glu Ser  
                 85                  90                  95      

Val Asp Trp Arg Asn Glu Ser Ala Val Leu Pro Val Lys Asp Gln Gly  
            100                 105                 110          

Asn Cys Gly Ser Cys Trp Ala Phe Ser Thr Ile Gly Ala Val Glu Gly  
        115                 120                 125              

Ile Asn Lys Ile Val Thr Gly Asp Leu Ile Ser Leu Ser Glu Gln Glu  
    130                 135                 140                  

Leu Val Asp Cys Asp Thr Ser Tyr Asn Gln Gly Cys Asn Gly Gly Leu  
145                 150                 155                 160  

Met Asp Tyr Ala Tyr Glu Phe Ile Ile Asn Asn Gly Gly Ile Asp Ser  
                165                 170                 175      

Glu Glu Asp Tyr Pro Tyr Arg Ala Val Asp Gly Thr Cys Asp Gln Tyr  
            180                 185                 190          

Arg Lys Asn Ala Lys Val Val Thr Ile Asp Ser Tyr Glu Asp Val Pro  
        195                 200                 205              

Ala Asn Asp Glu Leu Ala Leu Lys Lys Ala Val Ala Asn Gln Pro Val  
    210                 215                 220                  

Ser Val Ala Ile Glu Gly Gly Gly Arg Glu Phe Gln Leu Tyr Val Ser  
225                 230                 235                 240  

Gly Val Phe Thr Gly Arg Cys Gly Thr Ala Leu Asp His Gly Val Val  
                245                 250                 255      

Ala Val Gly Tyr Gly Ser Val Lys Gly His Asp Tyr Trp Ile Val Arg  
            260                 265                 270          

Asn Ser Trp Gly Ala Ser Trp Gly Glu Glu Gly Tyr Val Arg Leu Glu  
        275                 280                 285              

Arg Asn Leu Ala Lys Ser Arg Ser Gly Lys Cys Gly Ile Ala Ile Glu  
    290                 295                 300                  

Pro Ser Tyr Pro Ile Lys Asn Gly Ala Asn Pro Pro Asn Pro Gly Pro  
305                 310                 315                 320  

Ser Pro Pro Ser Pro Val Lys Pro Pro Asn Val Cys Asp Asn Ser Tyr  
                325                 330                 335      

Ser Cys Ser Asp Ser Ala Thr Cys Cys Cys Ile Phe Glu Phe Gln Lys  
            340                 345                 350          

Tyr Cys Met Val Trp Gly Cys Cys Pro Leu Glu Ala Ala Thr Cys Cys  
        355                 360                 365              

Asp Asp His Tyr Ser Cys Cys Pro His Glu Tyr Pro Ile Cys Asn Val  
    370                 375                 380                  

Arg Ala Gly Thr Cys Leu Lys Gly Lys Asn Asn Pro Phe Gly Val Lys  
385                 390                 395                 400  

Ala Leu Arg Arg Thr Pro Ala Lys Pro His Trp Ala Phe Gly Gly Lys  
                405                 410                 415      

Asn Lys Val Asn Ser Ala                                          
            420                                                  


