                                SEQUENCE LISTING

<110> CENTOCOR, INC.

<120> METHODS AND VECTORS FOR GENERATING
  ASIALYATED IMMUNOGLOBULINS

<130> CEN5159PCT


<140> To Be Assigned
<141> 2007-12-26

<150> 60/882301     
<151> 2006-12-28  

<160> 2

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 520
<212> PRT
<213> Arthrobacter ureafaciens

<400> 1
Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu
 1               5                  10                  15      
Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Pro Thr Pro Pro Asn Ser
            20                  25                  30          
Pro Thr Leu Pro Pro Gly Ser Phe Ser Glu Thr Asn Leu Ala Ala Asp
        35                  40                  45              
Arg Thr Ala Ala Asn Phe Phe Tyr Arg Ile Pro Ala Leu Thr Tyr Leu
    50                  55                  60                  
Gly Asn Asp Val Val Leu Ala Ala Trp Asp Gly Arg Pro Gly Ser Ala
65                  70                  75                  80  
Ala Asp Ala Pro Asn Pro Asn Ser Ile Val Gln Arg Arg Ser Thr Asp
                85                  90                  95      
Gly Gly Lys Thr Trp Gly Pro Val Gln Val Ile Ala Ala Gly His Val
            100                 105                 110         
Ala Asp Ala Ser Gly Pro Arg Tyr Gly Tyr Ser Asp Pro Ser Tyr Ile
        115                 120                 125             
Tyr Asp Ala Glu Ala Asn Lys Val Phe Ala Phe Phe Val Tyr Ser Lys
    130                 135                 140                 
Asp Gln Gly Phe Gly Gly Ser Gln Phe Gly Asn Asp Asp Ala Asp Arg
145                 150                 155                 160 
Asn Val Ile Ser Ser Ala Val Ile Glu Ser Ser Asp Ala Gly Val Thr
                165                 170                 175     
Trp Ser Gln Pro Arg Leu Ile Thr Ser Val Thr Lys Pro Gly Thr Ser
            180                 185                 190         
Lys Thr Asn Pro Ala Ala Gly Asp Val Arg Ser Asn Phe Ala Ser Ser
        195                 200                 205             
Gly Glu Gly Ile Gln Leu Lys Tyr Gly Pro His Lys Gly Arg Leu Ile
    210                 215                 220                 
Gln Gln Tyr Ala Gly Asp Val Arg Gln Ala Asp Gly Ser Asn Lys Ile
225                 230                 235                 240 

Gln Ala Tyr Ser Val Tyr Ser Asp Asp His Gly Val Thr Trp His Lys
                245                 250                 255     
Gly Ala Asn Val Gly Asp Arg Met Asp Glu Asn Lys Thr Val Glu Leu
            260                 265                 270         
Ser Asp Gly Arg Val Leu Leu Asn Ser Arg Asp Asn Ala Asn Arg Gly
        275                 280                 285             
Tyr Arg Lys Val Ala Val Ser Thr Asp Gly Gly Ala Thr Tyr Gly Pro
    290                 295                 300                 
Val Ser Gln Asp Thr Glu Leu Pro Asp Pro Ala Asn Asn Gly Ala Ile
305                 310                 315                 320 
Ala Arg Met Phe Pro Asn Ala Ala Gln Gly Ser Ala Asp Ala Lys Lys
                325                 330                 335     
Leu Ile Phe Thr Asn Ala Asn Ser Lys Thr Gly Arg Glu Asn Val Ser
            340                 345                 350         
Ala Arg Val Ser Cys Asp Asp Gly Glu Thr Trp Pro Gly Val Arg Thr
        355                 360                 365             
Ile Arg Ser Gly Phe Ser Ala Tyr Ser Thr Val Thr Arg Leu Ala Asp
    370                 375                 380                 
Gly Lys Phe Gly Val Leu Tyr Glu Gly Asn Tyr Thr Asp Asn Met Pro
385                 390                 395                 400 
Phe Ala Thr Phe Asp Asp Ala Trp Leu Asn Tyr Val Cys Ala Pro Leu
                405                 410                 415     
Ala Val Pro Ala Val Asn Ile Ala Pro Ser Ala Thr Gln Glu Val Pro
            420                 425                 430         
Val Thr Val Thr Asn Gln Glu Ala Thr Thr Leu Ser Gly Ala Thr Ala
        435                 440                 445             
Thr Val Tyr Thr Pro Ser Gly Trp Ser Ala Thr Thr Val Pro Val Pro
    450                 455                 460                 
Asp Val Ala Pro Gly Ala Ser Val Thr Val Thr Val Ala Leu Thr Ala
465                 470                 475                 480 
Pro Ala Asp Ala Ser Gly Pro Arg Ser Leu Asn Ala Ala Phe Thr Thr
                485                 490                 495     
Ala Asp Gly Arg Val Ser Gln Phe Thr Phe Thr Ala Thr Thr Pro Val
            500                 505                 510         
Ala Pro Gln Val Gly Leu Thr Ile
        515                 520 


<210> 2
<211> 1563
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleic acid sequence encoding the catalytic
      domain of the Arthrobacter ureafaciens sialidase.

<400> 2
atggctacag gctcccggac gtccctgctc ctggcttttg gcctgctctg cctgccctgg 60
cttcaagagg gatccgcccc cactccgccc aattcgccca cgcttccacc gggcagcttc 120
tctgaaacca atctggcggc cgaccgcacg gcggcgaatt tcttctaccg gattcccgcg 180
cttacctacc ttggcaacga cgtggtcctt gcagcgtggg acggtcgccc gggttcggcg 240
gcggacgccc cgaacccgaa ctcgatcgtc cagcgccgaa gcacggacgg tggcaagacc 300
tgggggccgg tccaagtgat cgccgcaggc cacgtcgccg atgccagcgg ccctcgatac 360
ggctacagcg atccctcgta catctacgac gcggaagcca acaaggtctt cgctttcttc 420
gtgtactcga aggaccaagg ctttggcggc agtcagttcg gcaacgacga cgcggaccgg 480
aacgtcattt cctccgccgt catcgagtct tccgacgccg gcgtgacatg gagccagccc 540
cgcctcatca cctccgtcac caagccgggt accagcaaga ccaacccggc agccggcgac 600
gtccgctcca actttgcctc ctccggtgag ggcatccagc tcaaatacgg cccgcacaag 660
ggccgtctca tccagcagta cgccggcgac gtgcggcaag ctgacggaag caacaagatc 720
caggcctaca gcgtctattc agacgatcac ggcgtcacgt ggcacaaggg tgccaacgtg 780
ggcgaccgga tggacgagaa caagactgtg gaactgtccg acggtcgggt cctgctcaac 840
tcccgggaca acgccaaccg gggctaccgc aaggtggccg tctccacgga cggcggagcc 900
acgtacggcc ccgtcagcca ggacacggaa ttgccggacc ctgccaacaa cggtgcaatc 960
gcccgcatgt tccccaacgc ggcgcagggc tccgcagacg cgaagaaact gatcttcacc 1020
aacgcaaact ccaagaccgg ccgcgaaaac gtctcggccc gggtctcctg tgacgacggc 1080
gaaacctggc cgggcgtccg caccatccgt tccggcttct cggcctactc aacagtgacc 1140
cgcctggcgg acggaaagtt cggcgtcctc tacgagggca actacacgga caacatgccc 1200
ttcgccacct tcgacgacgc gtggttgaac tacgtctgcg ctcccttggc agtaccggca 1260
gtcaacatcg ccccgagcgc aacgcaggag gttccggtga ccgtcactaa ccaggaagca 1320
accacgcttt ccggcgcgac cgcaactgtc tatacgccgt cggggtggtc tgccaccacg 1380
gtgcccgtgc ccgacgtcgc ccccggcgcg tccgtcaccg tgaccgttgc actgaccgca 1440
ccggcggacg ccagtggccc gcgcagcctc aacgcggcat tcacgacggc ggatggccgg 1500
gtttcgcagt tcaccttcac cgccaccacg cccgtggctc cgcaagtggg ccttaccatc 1560
tag                                                               1563


CEN5159PCT




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