
                                SEQUENCE LISTING

<110> Johns, Roger A.
      Su, Qingning
      Champion, Hunter C.

<120> HIMF AND BTK IN PULMONARY, CARDIAC, AND
  INFLAMMATION DISORDERS
  

<130> 201107.00012

<150> 60/875,504          
<151> 2006-12-18  

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 108
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Ala Leu Cys Leu Leu Leu Leu Pro Val Leu Gly Leu Leu Val
 1               5                  10                  15      
Ser Ser Lys Thr Leu Cys Ser Met Glu Glu Ala Ile Asn Glu Arg Ile
            20                  25                  30          
Gln Glu Val Ala Gly Ser Leu Ile Phe Arg Ala Ile Ser Ser Ile Gly
        35                  40                  45              
Leu Glu Cys Gln Ser Val Thr Ser Arg Gly Asp Leu Ala Thr Cys Pro
    50                  55                  60                  
Arg Gly Phe Ala Val Thr Gly Cys Thr Cys Gly Ser Ala Cys Gly Ser
65                  70                  75                  80  
Trp Asp Val Arg Ala Glu Thr Thr Cys His Cys Gln Cys Ala Gly Met
                85                  90                  95      
Asp Trp Thr Gly Ala Arg Cys Cys Arg Val Gln Pro
            100                 105             


<210> 2
<211> 111
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Pro Ser Ser Cys Leu Leu Leu Ile Leu Ile Pro Leu Leu Gln
 1               5                  10                  15      
Leu Ile Asn Pro Gly Ser Thr Gln Cys Ser Leu Asp Ser Val Met Asp
            20                  25                  30          
Lys Lys Ile Lys Asp Val Leu Asn Ser Leu Glu Tyr Ser Pro Ser Pro
        35                  40                  45              
Ile Ser Lys Lys Leu Ser Cys Ala Ser Val Lys Ser Gln Gly Arg Pro
    50                  55                  60                  
Ser Ser Cys Pro Ala Gly Met Ala Val Thr Gly Cys Ala Cys Gly Tyr
65                  70                  75                  80  
Gly Cys Gly Ser Trp Asp Val Gln Leu Glu Thr Thr Cys His Cys Gln
                85                  90                  95      
Cys Ser Val Val Asp Trp Thr Thr Ala Arg Cys Cys His Leu Thr
            100                 105                 110     


<210> 3
<211> 659
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln
 1               5                  10                  15      
Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu
            20                  25                  30          
Thr Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg
        35                  40                  45              
Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Thr Cys Val
    50                  55                  60                  
Glu Thr Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro
65                  70                  75                  80  
Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu
                85                  90                  95      
Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr
            100                 105                 110         
Val Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu
        115                 120                 125             
Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro
    130                 135                 140                 
Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala Lys
145                 150                 155                 160 
Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys
                165                 170                 175     
Pro Gly Ser Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr Pro
            180                 185                 190         
Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala
        195                 200                 205             
Ala Pro Val Ser Thr Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp
    210                 215                 220                 
Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu
225                 230                 235                 240 
Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp
                245                 250                 255     
Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Glu Ala
            260                 265                 270         
Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Thr Arg
        275                 280                 285             
Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe
    290                 295                 300                 
Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Thr Val Ser Val Phe
305                 310                 315                 320 
Ala Lys Ser Thr Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val
                325                 330                 335     
Cys Ser Thr Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe
            340                 345                 350         
Ser Thr Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly
        355                 360                 365             
Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys Asn Ala
    370                 375                 380                 
Pro Ser Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys
385                 390                 395                 400 
Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val
                405                 410                 415     
Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile
            420                 425                 430         
Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val
        435                 440                 445             
Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys
    450                 455                 460                 
Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly
465                 470                 475                 480 
Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln
                485                 490                 495     
Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu
            500                 505                 510         
Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu
        515                 520                 525             
Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg
    530                 535                 540                 
Tyr Val Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe Pro
545                 550                 555                 560 
Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser
                565                 570                 575     
Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser
            580                 585                 590         
Leu Gly Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala Glu
        595                 600                 605             
His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu
    610                 615                 620                 
Lys Val Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu
625                 630                 635                 640 
Arg Pro Thr Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met Asp
                645                 650                 655     
Glu Glu Ser
            


<210> 4
<211> 470
<212> DNA
<213> Homo sapiens

<400> 4
gtgtgccgga tttggttagc tgagcccacc gagagggatg aaagctctct gtctcctcct 60
cctccctgtc ctggggctgt tggtgtctag caagaccctg tgctccatgg aagaagccat 120
caatgagagg atccaggagg tcgccggctc cctaatattt agggcaataa gcagcattgg 180
cctggagtgc cagagcgtca cctccagggg ggacctggct acttgccccc gaggcttcgc 240
cgtcaccggc tgcacttgtg gctccgcctg tggctcgtgg gatgtgcgcg ccgagaccac 300
atgtcactgc cagtgcgcgg gcatggactg gaccggagcg cgctgctgtc gtgtgcagcc 360
ctgaggtcgc gcgcagcgcg tgcacagcgc gggcggaggc ggctccaggt ccggaggggt 420
tgcgggggag ctggaaataa acctggagat gatgatgatg atgatgatgg            470

<210> 5
<211> 595
<212> DNA
<213> Homo sapiens

<400> 5
gccacgttgt cttctttcct tcaccaccac ccaggagctc agagatctaa gctgctttcc 60
atcttttctc ccagccccag gacactgact ctgtacagga tggggccgtc ctcttgcctc 120
cttctcatcc taatccccct tctccagctg atcaacccgg ggagtactca gtgttcctta 180
gactccgtta tggataagaa gatcaaggat gttctcaaca gtctagagta cagtccctct 240
cctataagca agaagctctc gtgtgctagt gtcaaaagcc aaggcagacc gtcctcctgc 300
cctgctggga tggctgtcac tggctgtgct tgtggctatg gctgtggttc gtgggatgtt 360
cagctggaaa ccacctgcca ctgccagtgc agtgtggtgg actggaccac tgcccgctgc 420
tgccacctga cctgacaggg aggaggctga gaactcagtt ttgtgaccat gacagtaatg 480
aaaccagggt cccaaccaag aaatctaact caaacgtccc acttcatttg ttccattcct 540
gattcttggg taataaagac aaactttgta cctcaaaaaa aaaaaaaaaa aaaaa      595

<210> 6
<211> 2591
<212> DNA
<213> Homo sapiens

<400> 6
ctcagactgt ccttcctctc tggactgtaa gaatatgtct ccagggccag tgtctgctgc 60
gatcgagtcc caccttccaa gtcctggcat ctcaatgcat ctgggaagct acctgcatta 120
agtcaggact gagcacacag gtgaactcca gaaagaagaa gctatggccg cagtgattct 180
ggagagcatc tttctgaagc gatcccaaca gaaaaagaaa acatcacctc taaacttcaa 240
gaagcgcctg tttctcttga ccgtgcacaa actctcctac tatgagtatg actttgaacg 300
tgggagaaga ggcagtaaga agggttcaat agatgttgag aagatcactt gtgttgaaac 360
agtggttcct gaaaaaaatc ctcctccaga aagacagatt ccgagaagag gtgaagagtc 420
cagtgaaatg gagcaaattt caatcattga aaggttccct tatcccttcc aggttgtata 480
tgatgaaggg cctctctacg tcttctcccc aactgaagaa ctaaggaagc ggtggattca 540
ccagctcaaa aacgtaatcc ggtacaacag tgatctggtt cagaaatatc acccttgctt 600
ctggatcgat gggcagtatc tctgctgctc tcagacagcc aaaaatgcta tgggctgcca 660
aattttggag aacaggaatg gaagcttaaa acctgggagt tctcaccgga agacaaaaaa 720
gcctcttccc ccaacgcctg aggaggacca gatcttgaaa aagccactac cgcctgagcc 780
agcagcagca ccagtctcca caagtgagct gaaaaaggtt gtggcccttt atgattacat 840
gccaatgaat gcaaatgatc tacagctgcg gaagggtgat gaatatttta tcttggagga 900
aagcaactta ccatggtgga gagcacgaga taaaaatggg caggaaggct acattcctag 960
taactatgtc actgaagcag aagactccat agaaatgtat gagtggtatt ccaaacacat 1020
gactcggagt caggctgagc aactgctaaa gcaagagggg aaagaaggag gtttcattgt 1080
cagagactcc agcaaagctg gcaaatatac agtgtctgtg tttgctaaat ccacagggga 1140
ccctcaaggg gtgatacgtc attatgttgt gtgttccaca cctcagagcc agtattacct 1200
ggctgagaag caccttttca gcaccatccc tgagctcatt aactaccatc agcacaactc 1260
tgcaggactc atatccaggc tcaaatatcc agtgtctcaa caaaacaaga atgcaccttc 1320
cactgcaggc ctgggatacg gatcatggga aattgatcca aaggacctga ccttcttgaa 1380
ggagctgggg actggacaat ttggggtagt gaagtatggg aaatggagag gccagtacga 1440
cgtggccatc aagatgatca aagaaggctc catgtctgaa gatgaattca ttgaagaagc 1500
caaagtcatg atgaatcttt cccatgagaa gctggtgcag ttgtatggcg tctgcaccaa 1560
gcagcgcccc atcttcatca tcactgagta catggccaat ggctgcctcc tgaactacct 1620
gagggagatg cgccaccgct tccagactca gcagctgcta gagatgtgca aggatgtctg 1680
tgaagccatg gaatacctgg agtcaaagca gttccttcac cgagacctgg cagctcgaaa 1740
ctgtttggta aacgatcaag gagttgttaa agtatctgat ttcggcctgt ccaggtatgt 1800
cctggatgat gaatacacaa gctcagtagg ctccaaattt ccagtccggt ggtccccacc 1860
ggaagtcctg atgtatagca agttcagcag caaatctgac atttgggctt ttggggtttt 1920
gatgtgggaa atttactccc tggggaagat gccatatgag agatttacta acagtgagac 1980
tgctgaacac attgcccaag gcctacgtct ctacaggcct catctggctt cagagaaggt 2040
atataccatc atgtacagtt gttggcatga gaaagcagat gagcgtccca ctttcaaaat 2100
tcttctgagc aatattctag atgtcatgga tgaagaatcc tgagctcgcc aataagcttc 2160
ttggttctac ttctcttctc cacaagcccc aatttcactt tctcagagga aatcccaagc 2220
ttaggagccc tggagccttt gtgctcccac tcaatacaaa aaggcccctc tctacatctg 2280
gggatgcacc tcttctttga ttccctggga tagtggcttc tgagcaaagg ccaaaaaatt 2340
attgtgcctg aaatttcccg agagaattaa gacagactga atttgcgatg aaaatatttt 2400
ttaggaggga ggatgtaaat agccgcacaa aggggtccaa cagctctttg agtaggcatt 2460
tggtagagct tgggggtgtg tgtgtggggg tggaccgaat ttggcaagaa tgaaatggtg 2520
tcataaagat gggaggggag ggtgttttga taaaataaat tctagaaagc ttaaaaaaaa 2580
aaaaaaaaaa a                                                      2591
