                         SEQUENCE LISTING

<110>  Neurotune AG
       Universitt Zrich
 
<120>  Optiogenin for the treatment of neural diseases

<130>  P345A

<150>  EP06126746.4
<151>  2006-12-21

<160>  13    

<170>  PatentIn version 3.4

<210>  1
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Ala Gly Asp Val Asp Thr Leu Ala Phe Asp Gly Arg Thr Phe Val 
1               5                   10                  15      


Glu Tyr Leu Asn Ala Val Thr Glu Ser Glu Lys Ala Leu Gln Ser Asn 
            20                  25                  30          


His Phe Glu Leu Ser Leu Arg Thr Glu Ala Thr Gln Gly Leu Val Leu 
        35                  40                  45              


Trp Ser Gly Lys Ala Thr Glu Arg Ala Asp Tyr Val Ala Leu Ala Ile 
    50                  55                  60                  


Val Asp Gly His Leu Gln Leu Ser Tyr Asn Leu Gly Ser Gln Pro Val 
65                  70                  75                  80  


Val Leu Arg Ser Thr Val Pro Val Asn Thr Asn Arg Trp Leu Arg Val 
                85                  90                  95      


Val Ala His Arg Glu Gln Arg Glu Gly Ser Leu Gln Val Gly Asn Glu 
            100                 105                 110         


Ala Pro Val Thr Gly Ser Ser Pro Leu Gly Ala Thr Gln Leu Asp Thr 
        115                 120                 125             


Asp Gly Ala Leu Trp Leu Gly Gly Leu Pro Glu Leu Pro Val Gly Pro 
    130                 135                 140                 


Ala Leu Pro Lys Ala Tyr Gly Thr Gly Phe Val Gly Cys Leu Arg Asp 
145                 150                 155                 160 


Val Val Val Gly Arg His Pro Leu His Leu Leu Glu Asp Ala Val Thr 
                165                 170                 175     


Lys Pro Glu Leu Arg Pro Cys Pro Thr Pro 
            180                 185     


<210>  2
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Leu Ala Asn Glu Ile Pro Val 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Glu Thr Leu Asp Ser Gly Ala Leu His Ser 
1               5                   10      


<210>  4
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Ala Asp Phe Asn Gly Phe Ser His Leu Glu Leu Arg Gly Leu His 
1               5                   10                  15      


Thr Phe Ala Arg Asp Leu Gly Glu Lys Met Ala Leu Glu Val Val Phe 
            20                  25                  30          


Leu Ala Arg Gly Pro Ser Gly Leu Leu Leu Tyr Asn Gly Gln Lys Thr 
        35                  40                  45              


Asp Gly Lys Gly Asp Phe Val Ser Leu Ala Leu Arg Asp Arg Arg Leu 
    50                  55                  60                  


Glu Phe Arg Tyr Asp Leu Gly Lys Gly Ala Ala Val Ile Arg Ser Arg 
65                  70                  75                  80  


Glu Pro Val Thr Leu Gly Ala Trp Thr Arg Val Ser Leu Glu Arg Asn 
                85                  90                  95      


Gly Arg Lys Gly Ala Leu Arg Val Gly Asp Gly Pro Arg Val Leu Gly 
            100                 105                 110         


Glu Ser Pro Val Pro His Thr Val Leu Asn Leu Lys Glu Pro Leu Tyr 
        115                 120                 125             


Val Gly Gly Ala Pro Asp Phe Ser Lys Leu Ala Arg Ala Ala Ala Val 
    130                 135                 140                 


Ser Ser Gly Phe Asp Gly Ala Ile Gln Leu Val Ser Leu Gly Gly Arg 
145                 150                 155                 160 


Gln Leu Leu Thr Pro Glu His Val Leu Arg Gln Val Asp Val Thr Ser 
                165                 170                 175     


Phe Ala Gly His Pro Cys Thr Arg Ala Ser Gly His Pro Cys Leu Asn 
            180                 185                 190         


Gly Ala Ser Cys Val Pro Arg Glu Ala Ala Tyr Val Cys Leu Cys Pro 
        195                 200                 205             


Gly Gly Phe Ser Gly Pro His Cys Glu Lys Gly Leu Val Glu Lys Ser 
    210                 215                 220                 


Ala Gly Asp Val Asp Thr Leu Ala Phe Asp Gly Arg Thr Phe Val Glu 
225                 230                 235                 240 


Tyr Leu Asn Ala Val Thr Glu Ser Glu Lys Ala Leu Gln Ser Asn His 
                245                 250                 255     


Phe Glu Leu Ser Leu Arg Thr Glu Ala Thr Gln Gly Leu Val Leu Trp 
            260                 265                 270         


Ser Gly Lys Ala Thr Glu Arg Ala Asp Tyr Val Ala Leu Ala Ile Val 
        275                 280                 285             


Asp Gly His Leu Gln Leu Ser Tyr Asn Leu Gly Ser Gln Pro Val Val 
    290                 295                 300                 


Leu Arg Ser Thr Val Pro Val Asn Thr Asn Arg Trp Leu Arg Val Val 
305                 310                 315                 320 


Ala His Arg Glu Gln Arg Glu Gly Ser Leu Gln Val Gly Asn Glu Ala 
                325                 330                 335     


Pro Val Thr Gly Ser Ser Pro Leu Gly Ala Thr Gln Leu Asp Thr Asp 
            340                 345                 350         


Gly Ala Leu Trp Leu Gly Gly Leu Pro Glu Leu Pro Val Gly Pro Ala 
        355                 360                 365             


Leu Pro Lys Ala Tyr Gly Thr Gly Phe Val Gly Cys Leu Arg Asp Val 
    370                 375                 380                 


Val Val Gly Arg His Pro Leu His Leu Leu Glu Asp Ala Val Thr Lys 
385                 390                 395                 400 


Pro Glu Leu Arg Pro Cys Pro Thr Pro 
                405                 


<210>  5
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Ser Arg Lys 
1               


<210>  6
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  leader sequence

<400>  6

Ala Arg Val Asn 
1               


<210>  7
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  GS linker sequence

<400>  7

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  8
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Streptag

<400>  8

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  9
<211>  62
<212>  DNA
<213>  Artificial

<220>
<223>  Primer introducing Hpal site 5'

<400>  9
gcgcgagtta accaccatca ccatcaccat caccattcag cgggggacgt ggataccttg     60

gc                                                                    62


<210>  10
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Primer introducing Notl site 3'

<400>  10
ttacctgcgg ccgctcatgg ggtggggcag ggccgcagct c                         41


<210>  11
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  ARVN-His8 leader

<400>  11

Ala Arg Val Asn His His His His His His His His 
1               5                   10          


<210>  12
<211>  73
<212>  DNA
<213>  Artificial

<220>
<223>  Primer introducing Hpal site 5'

<400>  12
gcgcgagtta acgttaacca ccatcaccat caccatcacc atggaagcct ggctgacttc     60

aacggcttct ccc                                                        73


<210>  13
<211>  78
<212>  DNA
<213>  Artificial

<220>
<223>  Primer introcuing Notl site 3'

<400>  13
acctgcggcc gctcattttt cgaactgcgg atggctccag ccagagccag agcctggggt     60

ggggcagggc cgcagctc                                                   78


