3080206_1.TXT 
SEQUENCE LISTING 
<110> ZHOU, Xiao-Mai 
TAVARES, Daniel 
<120> METHODS FOR IMPROVING ANTIBODY PRODUCTION 
<130> A9267 
<150> US 60/855361 
<151> 2006-10-31 
<160> 16 
<170> PatentIn version 3.3 
<210> 1 
<211> 119 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> huC242 heavy chain 
<400> 1 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1 5 10 15 
Thr Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Thr Phe Thr Tyr Tyr 
20 25 30 
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
35 40 45 
Gly Trp Ile Asp Thr Thr Thr Gly Glu Pro Thr Tyr Ala Gln Lys Phe 
50 55 60 
Gln Gly Arg Ile Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65 70 75 80 
Leu Gln Ile Lys Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
85 90 95 
Ala Arg Arg Gly Pro Tyr Asn Trp Tyr Phe Asp Val Trp Gly Gln Gly 
100 105 110 
Thr Thr Val Thr Val Ser Ser 
115 
<210> 2 
<211> 112 
<212> PRT 
<213> Artificial Sequence 
Page 1

3080206_1.TXT 
<220> 
<223> huC242 light chain 
<400> 2 
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Val Pro Val Thr Pro Gly 
1 5 10 15 
Glu Pro Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
20 25 30 
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
35 40 45 
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Val Ser Gly Val Pro 
50 55 60 
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65 70 75 80 
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln His 
85 90 95 
Leu Glu Tyr Pro Phe Thr Phe Gly Pro Gly Thr Lys Leu Glu Leu Lys 
100 105 110 
<210> 3 
<211> 132 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> murine heavy chain consensus sequence 
<400> 3 
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1 5 10 15 
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
20 25 30 
Trp Met His Asn Ser Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu 
35 40 45 
Trp Ile Gly Tyr Ile Asn Pro Lys Ala Gly Asn Gly Gly Thr Lys Tyr 
50 55 60 
Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
65 70 75 80 
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3080206_1.TXT 
Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
85 90 95 
Val Tyr Tyr Cys Ala Arg Tyr Tyr Tyr Tyr Gly Gly Ser Tyr Tyr Tyr 
100 105 110 
Tyr Tyr Tyr Tyr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
115 120 125 
Thr Val Ser Ser 
130 
<210> 4 
<211> 119 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> murine light chain consensus sequence 
<400> 4 
Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Leu Gly 
1 5 10 15 
Glu Lys Val Thr Ile Ser Cys Arg Ala Ser Gln Ser Leu Leu His Ser 
20 25 30 
Gly Asn Gly Asn Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln 
35 40 45 
Ser Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val 
50 55 60 
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65 70 75 80 
Ile Ser Ser Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
85 90 95 
Trp Ser Ser Tyr Pro Pro Ser Thr His Thr Pro Leu Thr Phe Gly Gly 
100 105 110 
Gly Thr Lys Leu Glu Ile Lys 
115 
<210> 5 
<211> 132 
<212> PRT 
<213> Artificial Sequence 
Page 3

3080206_1.TXT 
<220> 
<223> huC242 light chain sequence 
<400> 5 
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1 5 10 15 
Val His Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Val Pro Val 
20 25 30 
Thr Pro Gly Glu Pro Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu 
35 40 45 
Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro 
50 55 60 
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Val Ser 
65 70 75 80 
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr 
85 90 95 
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
100 105 110 
Leu Gln His Leu Glu Tyr Pro Phe Thr Phe Gly Pro Gly Thr Lys Leu 
115 120 125 
Glu Leu Lys Arg 
130 
<210> 6 
<211> 132 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> huMy96 light chain sequence 
<400> 6 
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1 5 10 15 
Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val 
20 25 30 
Ser Pro Gly Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val 
35 40 45 
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3080206_1.TXT 
Phe Phe Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile 
50 55 60 
Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
65 70 75 80 
Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
85 90 95 
Thr Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr 
100 105 110 
Cys His Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu 
115 120 125 
Glu Ile Lys Arg 
130 
<210> 7 
<211> 122 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> rB4 light chain sequence 
<400> 7 
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1 5 10 15 
Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
20 25 30 
Ser Pro Gly Glu Arg Val Thr Met Thr Cys Ser Ala Ser Val Asn Tyr 
35 40 45 
Met His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Arg Arg Trp Ile 
50 55 60 
Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
65 70 75 80 
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Glu Pro 
85 90 95 
Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Gly Ser Tyr Thr Phe 
100 105 110 
Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
Page 5

3080206_1.TXT 
115 120 
<210> 8 
<211> 132 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> huEM164 light chain sequence 
<400> 8 
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1 5 10 15 
Val His Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
20 25 30 
Ser Leu Gly Asp Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
35 40 45 
Val His Ser Asn Val Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
50 55 60 
Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65 70 75 80 
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr 
85 90 95 
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys 
100 105 110 
Phe Gln Gly Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
115 120 125 
Glu Ile Lys Arg 
130 
<210> 9 
<211> 132 
<212> PRT 
<213> Artificial sequence 
<220> 
<223> huN901 light chain sequence 
<400> 9 
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1 5 10 15 
Page 6

3080206_1.TXT 
Val His Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
20 25 30 
Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ile Ile 
35 40 45 
Ile His Ser Asp Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro 
50 55 60 
Gly Gln Ser Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65 70 75 80 
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
85 90 95 
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
100 105 110 
Phe Gln Gly Ser His Val Pro His Thr Phe Gly Gln Gly Thr Lys Val 
115 120 125 
Glu Ile Lys Arg 
130 
<210> 10 
<211> 121 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> light chain consensus sequence 
<400> 10 
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1 5 10 15 
Val His Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
20 25 30 
Ser Pro Gly Glu Pro Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
35 40 45 
Ile His Ser Asn Thr Tyr Leu Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
50 55 60 
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Ser Gly Val Pro Asp 
65 70 75 80 
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
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3080206_1.TXT 
85 90 95 
Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Gln Pro Thr Phe 
100 105 110 
Gly Gly Thr Lys Leu Glu Ile Lys Arg 
115 120 
<210> 11 
<211> 468 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> huC242 heavy chain sequence 
<400> 11 
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1 5 10 15 
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
20 25 30 
Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Thr Phe 
35 40 45 
Thr Tyr Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
50 55 60 
Lys Trp Met Gly Trp Ile Asp Thr Thr Thr Gly Glu Pro Thr Tyr Ala 
65 70 75 80 
Gln Lys Phe Gln Gly Arg Ile Ala Phe Ser Leu Glu Thr Ser Ala Ser 
85 90 95 
Thr Ala Tyr Leu Gln Ile Lys Ser Leu Lys Ser Glu Asp Thr Ala Thr 
100 105 110 
Tyr Phe Cys Ala Arg Arg Gly Pro Tyr Asn Trp Tyr Phe Asp Val Trp 
115 120 125 
Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
130 135 140 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145 150 155 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
165 170 175 
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3080206_1.TXT 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
180 185 190 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
195 200 205 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
210 215 220 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225 230 235 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
245 250 255 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
260 265 270 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
275 280 285 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
290 295 300 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305 310 315 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
325 330 335 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
340 345 350 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
355 360 365 
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
370 375 380 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385 390 395 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
405 410 415 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
Page 9

3080206_1.TXT 
420 425 430 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
435 440 445 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
450 455 460 
Ser Pro Gly Lys 
465 
<210> 12 
<211> 1404 
<212> DNA 
<213> Artificial Sequence 
<220> 
<223> huC242 heavy chain sequence 
<400> 12 
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt ccactcccag 60 
gtccagttgg tgcagtctgg agccgaggtg aagaagcctg gagagacagt caagatctcc 120 
tgcaaggctt ctgattatac cttcacatac tatggaatga actgggtgaa gcaggctccg 180 
ggacagggtc tgaagtggat gggctggatc gacaccacca ctggagagcc aacatatgct 240 
cagaagtttc agggacggat tgccttctct ttggagacct ctgccagcac tgcctatctg 300 
cagatcaaaa gcctgaaatc tgaggacacc gctacatatt tctgtgccag acgggggcct 360 
tacaactggt actttgatgt ctggggccag gggaccacgg tcaccgtctc ctcagcctcc 420 
accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 480 
gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 540 
tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 600 
tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 660 
tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct 720 
tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca 780 
gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 840 
acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 900 
gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 960 
taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 1020 
aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1080 
aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1140 
aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1200 
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gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1260 
tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag 1320 
gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1380 
agcctctccc tgtctccggg taaa 1404 
<210> 13 
<211> 238 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> huC242 light chain sequence 
<400> 13 
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1 5 10 15 
Val His Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Val Pro Val 
20 25 30 
Thr Pro Gly Glu Pro Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu 
35 40 45 
Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro 
50 55 60 
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Val Ser 
65 70 75 80 
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr 
85 90 95 
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
100 105 110 
Leu Gln His Leu Glu Tyr Pro Phe Thr Phe Gly Pro Gly Thr Lys Leu 
115 120 125 
Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
130 135 140 
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145 150 155 160 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
165 170 175 
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3080206_1.TXT 
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
180 185 190 
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
195 200 205 
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
210 215 220 
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225 230 235 
<210> 14 
<211> 714 
<212> DNA 
<213> Artificial Sequence 
<220> 
<223> huC242 light chain sequence 
<400> 14 
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt ccactccgat 60 
attgtgatga ctcagtctcc actgtctgta cctgtcactc ctggagagcc tgtatccatc 120 
tcctgcaggt ctagtaagag tctcctgcat agtaatggca acacttactt gtattggttc 180 
ctgcagaggc caggccagtc tcctcagctc ctgatatatc ggatgtccaa cctggtctca 240 
ggagtcccag acaggttcag tggcagtggg tcaggaactg ctttcacact gagaatcagt 300 
agagtggagg ctgaggatgt gggtgtttat tactgtctgc aacatctgga gtatccgttc 360 
acgttcggtc ctgggaccaa gctggagctg aaacgaactg tggctgcacc atctgtcttc 420 
atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 480 
aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 540 
ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 600 
agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 660 
acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt 714 
<210> 15 
<211> 119 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> huC242 heavy chain variable domain sequence 
<400> 15 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1 5 10 15 
Page 12

3080206_1.TXT 
Thr Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Thr Phe Thr Tyr Tyr 
20 25 30 
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
35 40 45 
Gly Trp Ile Asp Thr Thr Thr Gly Glu Pro Thr Tyr Ala Gln Lys Phe 
50 55 60 
Gln Gly Arg Ile Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65 70 75 80 
Leu Gln Ile Lys Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
85 90 95 
Ala Arg Arg Gly Pro Tyr Asn Trp Tyr Phe Asp Val Trp Gly Gln Gly 
100 105 110 
Thr Thr Val Thr Val Ser Ser 
115 
<210> 16 
<211> 113 
<212> PRT 
<213> Artificial Sequence 
<220> 
<223> huC242 light chain variable domain sequence 
<400> 16 
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Val Pro Val Thr Pro Gly 
1 5 10 15 
Glu Pro Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
20 25 30 
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
35 40 45 
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Val Ser Gly Val Pro 
50 55 60 
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65 70 75 80 
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln His 
85 90 95 
Page 13

3080206_1.TXT 
Leu Glu Tyr Pro Phe Thr Phe Gly Pro Gly Thr Lys Leu Glu Leu Lys 
100 105 110 
Arg 
Page 14

