                                SEQUENCE LISTING
<110> Abbott Laboratories
Tu, Bailin
      Tyner, Joan
	Ziemann, Robert N.      
      Hawksworth, David
	Scheffel, James
White, Michael
      Wernecke, Jeffrey M.      
      Pinkus, Mary S.
      Gutierrez, Robin
   
<120> Recombinant Antibodies against Hepatitis
  C Virus and Methods of Obtaining and Using Same
  
<130> 8339WO01

<150> US/633,810                 
<151> 2006-12-05  

<160> 111

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core 201-603 Antibody VH Region

<400> 1
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Gln Lys Pro Gly Lys
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Arg Val Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asp Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Gly Gly Gly Val Arg Arg Gln Val Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120 

<210> 2
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core 201-603 Antibody VL Region


<400> 2
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Asp Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln
                85                  90                  95      
Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 3
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV Core 201-603 Antibody VL 5' Primer

<400> 3
gctcgcgatg cgacattgtg atgtcacagt ct                               32

<210> 4
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV Core 201-603 Antibody VL 3' Primer

<400> 4
caccgtacgt tttatttcca gcttggt                                     27

<210> 5
<211> 56
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV Core 201-603 Antibody VH 5' Primer

<400> 5
ttgtcgcgat tttaaaaggt gtccagtgcc agatccagtt ggtgcagtct ggacct     56

<210> 6
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV Core 201-603 Antibody VH 3' Primer

<400> 6
ttggtcgacg ctgaggagac ggtgactgag gtt                              33

<210> 7
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core 201-603 Antibody VH
      Region

<400> 7
cagatccagt tggtgcagtc tggacctgag ctgcagaagc ctggaaagac agtcaagatc 60
tcctgcaaga cttctggtta taccttcaca gactatccaa tgcactgggt gaagcaggct 120
ccaggaaagg gtttaaagtg gatgggctgg ataaacactg agactggtga gccaacacgt 180
gtagatgact tcaagggacg ttttgccttc tctttggaaa cctctgccag cactgcctat 240
ttgcagatca acaacctcaa agatgaggac acggccacat atttctgcgc tagagggggt 300
ggggtccgac gccaggttat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca 360


<210> 8
<211> 337
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core 201-603 Antibody VL
      Region

<400> 8
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact 60
atgagctgca aatccagtca gagtctgctc aatagtagaa cccgaaagaa ctacttggtt 120
tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg 180
gattctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc 240
atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctg 300
tacacgttcg gaggggggac caagctggaa ataaaac                          337

<210> 9
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antibody VH Region

<400> 9
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Ala
        35                  40                  45              
Ala Tyr Ile Ser Asn Gly Ala Gly Ser Thr Tyr Tyr Pro Asp Thr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  

Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      


Ala Arg Gly Leu Trp Asp Gly Leu Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110         
Leu Thr Val Ser Ser
        115         


<210> 10
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antibody VL Region

<400> 10
Asp Val Val Met Ala Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
                85                  90                  95      
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 11
<211> 56
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antibody VL 5' Primer

<400> 11
ctgtggttcc ccggctcgcg atgcgatgtt gtgatggccc aaactccact ctcccc     56

<210> 12
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antibody VL 3' Primer

<400> 12
gcgcatgcgt cgtacgtttt atttccagct tggtcccccc                       40

<210> 13
<211> 68
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antibody VH 5' Primer

<400> 13
ggctttttct tgtcgcgatt ttaaaaggtg tccagtgcga agtgaagctg gtggagtctg 60
ggggaggc                                                          68

<210> 14
<211> 53
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antibody VH 3' Primer

<400> 14
gcgcatgcat gcattgtcga cgcgaggaga ctgtgagagt ggtgccttgg ccc        53

<210> 15
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS3 Antibody VH Region

<400> 15
gaagtgaagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgaaactc 60
tcctgtgcaa cctctggatt cactttcagt gactattata tgtattgggt tcgccagact 120
ccagagaaga ggctggagtg ggccgcatac attagtaatg gtgctggtag cacctattat 180
ccagacactg taaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac 240
ctgcaaatga gccgtctgaa gtctgaggac acagccatgt attactgtgc aagaggcctc 300
tgggacggcc ttgactactg gggccaaggc accactctca cagtctcctc g          351

<210> 16
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS3 Antibody VL Region

<400> 16
gatgttgtga tggcccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc 60
atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg 120
tacctgcaga ggccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt 180
tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc 240
agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg 300
tacacgttcg gaggggggac caagctggaa ataaaacgt                        339

<210> 17
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antibody VH Region

<400> 17
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Ser Met His Trp Val Asn Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Thr Arg Gly Gly Thr Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
            100                 105                 110         
Ser Ser
        


<210> 18
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antibody VL Region

<400> 18
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
                85                  90                  95      
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 19
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antibody VL 5' Primer

<400> 19
gctcgcgatg cgatgttgtg atgacccaaa c                                31

<210> 20
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antibody VL 3' Primer

<400> 20
caccgtacgt ttgatttcca gcttggtgc                                   29

<210> 21
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antibody VH 5' Primer

<400> 21
tacttcgcga cagatccagt tggtgcagtc                                  30

<210> 22
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antibody VH 3' Primer

<400> 22
tggtcgacgc tgaggagact gtgagagtgg t                                31

<210> 23
<211> 342
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS4 Antibody VH Region

<400> 23
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc 60
tcctgcaagg cttctggtta taccttcaca gactattcaa tgcactgggt gaaccaggct 120
ccaggaaagg gtttaaagtg gatgggctgg ataaacactg agactggtga gccaacatat 180
gcagatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat 240
ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtac taggggaggc 300
acgggctact ggggccaagg caccactctc acagtctcct ca                    342

<210> 24
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS4 Antibody VL Region

<400> 24
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc 60
atctcttgca gatctagtca gagccttgta tacagtaatg gaaacaccta tttacattgg 120
tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt 180
tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc 240
agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg 300
tggacgttcg gtggaggcac caagctggaa atcaaacgg                        339

<210> 25
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antibody VH Region

<400> 25
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Arg Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ala
        115 


<210> 26
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antibody VL Region

<400> 26
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
            20                  25                  30          
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      

Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
            100                 105                 110         
Lys Arg
        


<210> 27
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antibody VL 5' Primer

<400> 27
gctcgcgatg cgacattgtg atgtcacagt                                  30

<210> 28
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antibody VL 3' Primer

<400> 28
caccgtacgt ttcagctcca gcttggt                                     27

<210> 29
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antibody VH 5' Primer

<400> 29
tacttcgcga gaggttcagc tgcagcagt                                   29

<210> 30
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antibody VH 3' Primer

<400> 30
tggtcgacgc tgcagagaca gtgaccag                                    28

<210> 31
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS5 Antibody VH Region

<400> 31
gaggttcagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg 60
tcctgcacag cttctggctt caacattaaa gacacctata tgcactgggt gaagcagagg 120
cctgaacagg gcctggagtg gattggaagg attgatcctg cgaatggtaa tactaaatat 180
gacccgaagt tccagggcaa ggccactata acagcagaca catcctccaa cacagcctac 240
ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtgc tagatcgcgg 300
gagtttgctt actggggcca agggactctg gtcactgtct ctgca                 345

<210> 32
<211> 342
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS5 Antibody VL Region

<400> 32
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact 60
atgagctgca agtccagtca gagcctttta tatagtagca atcaaaagaa ctacttggcc 120
tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg 180
gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc 240
atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat 300
ccgctcacgt tcggtgctgg gaccaagctg gagctgaaac gg                    342

<210> 33
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antigenic Fragment

<400> 33
Gly Gly Val Tyr Leu
 1               5  


<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antigenic Fragment

<400> 34
Gly Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg
 1               5                  10              


<210> 35
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antigenic Fragment


<400> 35
Ala Lys Ala Val Asp Phe Val Pro Val Glu Ser Leu Glu Thr Thr Met
 1               5                  10                  15      
Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro
            20                  25          


<210> 36
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antigenic Fragment

<400> 36
Pro Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu
 1               5                  10                  15      
Met Glu Glu Cys Ser Gln
            20          


<210> 37
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antigenic Fragment

<400> 37
Ala Glu Ser Tyr Ser Ser Met Pro Pro Leu Glu Gly Glu Pro Gly Asp
 1               5                  10                  15      
Pro Asp Leu Ser Asp Gly Ser Trp Ser Thr Val
            20                  25          


<210> 38
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core 14-153 Antibody VH Region

<400> 38
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ile Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      

Ala Arg Ala Gly Gly Asp Tyr Tyr Asp Ser Ser Tyr Asp Tyr Ala Met
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120                 125 


<210> 39
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core 14-153 Antibody VL Region

<400> 39
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
            20                  25                  30          
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                 110         


<210> 40
<211> 375
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core 14-153 Antibody VH
      Region

<400> 40
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc 60
tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaagct 120
ccaggaaagg gtttaaagtg gatgggctgg ataaacacca acactggaga gccaacatat 180
gctgaagagt tcaagggacg gtttgccttc tctttggaaa cctctgccat cactgcctat 240
ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagagcgggg 300
ggagattact acgatagtag ctacgactat gctatggact actggggtca aggaacctca 360
gtcaccgtct cctca                                                  375

<210> 41
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core 14-153 Antibody VL
      Region


<400> 41
gacattgtgc tgacccaatc cccagcttct ttggctgtgt ctctagggca gagggccacc 60
atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac 120
caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct 180
gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat 240
cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga ggatccgtgg 300
acgttcggtg gaggcaccaa gctggaaatc aaacgt                           336

<210> 42
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VH Region CDR1

<400> 42
Gly Tyr Thr Phe Thr Asp Tyr Pro
 1               5              


<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VH Region CDR2 and NS4 Antibody VH Region CDR2 

<400> 43
Ile Asn Thr Glu Thr Gly Glu Pro
 1               5              


<210> 44
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VH Region CDR3

<400> 44
Ala Arg Gly Gly Gly Val Arg Arg Gln Val Met Asp Tyr
 1               5                  10              


<210> 45
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VL Region CDR1

<400> 45
Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr
 1               5                  10          


<210> 46
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VL Region CDR2 and HCV NS5 Antibody VL Region CDR2

<400> 46
Trp Ala Ser
 1          


<210> 47
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VL Region CDR3

<400> 47
Lys Gln Ser Tyr Asn Leu Tyr Thr
 1               5              


<210> 48
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VH Region CDR1

<400> 48
Gly Tyr Thr Phe Thr Asn Tyr Gly
 1               5              


<210> 49
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VH Region CDR2

<400> 49
Ile Asn Thr Asn Thr Gly Glu Pro
 1               5              


<210> 50
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VH Region CDR3

<400> 50
Ala Arg Ala Gly Gly Asp Tyr Tyr Asp Ser Ser Tyr Asp Tyr Ala Met
 1               5                  10                  15      
Asp Tyr
        


<210> 51
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VL Region CDR1

<400> 51
Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr
 1               5                  10  


<210> 52
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VL Region CDR2



<400> 52
Ala Ala Ser
 1          


<210> 53
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VL Region CDR3

<400> 53
Gln Gln Ser Asn Glu Asp Pro Trp Thr
 1               5                  


<210> 54
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antibody VH Region CDR1

<400> 54
Gly Phe Thr Phe Ser Asp Tyr Tyr
 1               5              


<210> 55
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antibody VH Region CDR2

<400> 55
Ile Ser Asn Gly Ala Gly Ser Thr
 1               5              


<210> 56
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antibody VH Region CDR3

<400> 56
Ala Arg Gly Leu Trp Asp Gly Leu Asp Tyr
 1               5                  10  


<210> 57
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antibody VL Region CDR1
      

<400> 57
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr
 1               5                  10      


<210> 58
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antibody VL Region CDR2 and NS4 Antibody VL Region CDR2
      

<400> 58
Lys Val Ser
 1          


<210> 59
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antibody VL Region CDR3
      

<400> 59
Ser Gln Ser Thr His Val Pro Tyr Thr
 1               5                  


<210> 60
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antibody VH Region CDR1
      

<400> 60
Gly Tyr Thr Phe Thr Asp Tyr Ser
 1               5              


<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antibody VH Region CDR3



<400> 61
Thr Arg Gly Gly Thr Gly Tyr
 1               5          


<210> 62
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antibody VL Region CDR1

<400> 62
Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr
 1               5                  10      


<210> 63
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antibody VL Region CDR3

<400> 63
Ser Gln Ser Thr His Val Pro Trp Thr
 1               5                  


<210> 64
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antibody VH Region CDR1

<400> 64
Gly Phe Asn Ile Lys Asp Thr Tyr
 1               5              


<210> 65
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antibody VH Region CDR2

<400> 65
Ile Asp Pro Ala Asn Gly Asn Thr
 1               5              


<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antibody VH Region CDR3

<400> 66
Ala Arg Ser Arg Glu Phe Ala Tyr
 1               5              


<210> 67
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antibody VL Region CDR1


<400> 67
Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr
 1               5                  10          


<210> 68
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antibody VL Region CDR3

<400> 68
Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr
 1               5                  


<210> 69
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core Antibody VH Region CDR1

<400> 69
ggttatacct tcacagacta tcca                                        24

<210> 70
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core Antibody VH Region CDR2 and NS4 Antibody VH Region CDR2

<400> 70
ataaacactg agactggtga gcca                                        24

<210> 71
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core Antibody VH Region CDR3

<400> 71
gctagagggg gtggggtccg acgccaggtt atggactac                        39

<210> 72
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core Antibody VL Region CDR1

<400> 72
cagagtctgc tcaatagtag aacccgaaag aactac                           36

<210> 73
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core Antibody VL Region CDR2 and NS5 Antibody VL Region CDR2

<400> 73
tgggcatcc                                                         9

<210> 74
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core Antibody VL Region CDR3

<400> 74
aagcaatctt ataatctgta cacg                                        24

<210> 75
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core Antibody VH Region CDR1

<400> 75
gggtatacct tcacaaacta tgga                                        24

<210> 76
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core Antibody VH Region CDR2

<400> 76
ataaacacca acactggaga gcca                                        24

<210> 77
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core Antibody VH Region CDR3

<400> 77
gcaagagcgg ggggagatta ctacgatagt agctacgact atgctatgga ctac       54

<210> 78
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core Antibody VL Region CDR1

<400> 78
caaagtgttg attatgatgg tgatagttat                                  30

<210> 79
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core Antibody VL Region CDR2

<400> 79
gctgcatcc                                                         9

<210> 80
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV Core Antibody VL Region CDR3

<400> 80
cagcaaagta atgaggatcc gtggacg                                     27

<210> 81
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS3 Antibody VH Region CDR1

<400> 81
ggattcactt tcagtgacta ttat                                        24

<210> 82
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS3 Antibody VH Region CDR2

<400> 82
attagtaatg gtgctggtag cacc                                        24

<210> 83
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS3 Antibody VH Region CDR3

<400> 83
gcaagaggcc tctgggacgg ccttgactac                                  30

<210> 84
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS3 Antibody VL Region CDR1

<400> 84
cagagccttg tacacagtaa tggaaacacc tat                              33

<210> 85
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS3 Antibody VL Region CDR2 and NS4 Antibody VL Region CDR2

<400> 85
aaagtttcc                                                         9

<210> 86
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS3 Antibody VL Region CDR3

<400> 86
tctcaaagta cacatgttcc gtacacg                                     27

<210> 87
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS4 Antibody VH Region CDR1

<400> 87
ggttatacct tcacagacta ttca                                        24

<210> 88
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS4 Antibody VH Region CDR3

<400> 88
actaggggag gcacgggcta c                                           21

<210> 89
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS4 Antibody VL Region CDR1

<400> 89
cagagccttg tatacagtaa tggaaacacc tat                              33

<210> 90
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS4 Antibody VL Region CDR3

<400> 90
tctcaaagta cacatgttcc gtggacg                                     27

<210> 91
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS5 Antibody VH Region CDR1

<400> 91
ggcttcaaca ttaaagacac ctat                                        24

<210> 92
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS5 Antibody VH Region CDR2

<400> 92
attgatcctg cgaatggtaa tact                                        24

<210> 93
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS5 Antibody VH Region CDR3

<400> 93
gctagatcgc gggagtttgc ttac                                        24

<210> 94
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS5 Antibody VL Region CDR1

<400> 94
cagagccttt tatatagtag caatcaaaag aactac                           36

<210> 95
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence encoding HCV NS5 Antibody VL Region CDR3

<400> 95
cagcaatatt atagctatcc gctcacg                                     27

<210> 96
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VL 5' Primer

<400> 96
aaattttcgc gatgcgacat tgtgctgacc caatctc                          37

<210> 97
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VL 3' Primer

<400> 97
actactcgta cgtttgattt ccagcttggt gcct                             34

<210> 98
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VH 5' Primer

<400> 98
aaattttcgc gattttaaaa ggtgtccagt gtcagatcca gttggtgcag tctgg      55

<210> 99
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> HCV Core Antibody VH 3' Primer

<400> 99
tcctttgtcg acgctgagga gacggtgact gaggtt                           36

<210> 100
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antigenic Fragment

<400> 100
Gln Ile Val Gly Gly Val Tyr Leu 
 1               5                           

<210> 101
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antigenic Fragment

<220> 
<221> VARIANT        
<222> 2, 6, 7

<223> Xaa = Any Amino Acid

<400> 101
Gln Xaa Val Gly Gly Xaa Xaa Leu 
 1               5                           

<210> 102
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV Core Antigenic Fragment

<220> 
<221> VARIANT        
<222> 2, 6, 7

<223> Xaa1, Xaa2, and Xaa3 = Ala or Gly

<400> 102
Gln Xaa Val Gly Gly Xaa Xaa Leu 
 1               5                           

<210> 103
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antigenic Fragment

<400> 103
Asp Phe Val Pro Val Glu Ser Leu Glu Thr Thr Met 
 1               5                  10               

<210> 104
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antigenic Fragment

<220> 
<221> VARIANT        
<222> 5, 7, 10, 11

<223> Xaa = Any Amino Acid

<400> 104
Asp Phe Val Pro Xaa Glu Xaa Leu Glu Xaa Xaa Met 
 1               5                  10               

<210> 105
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS3 Antigenic Fragment

<220> 
<221> VARIANT        
<222> 5, 7, 10, 11

<223> Xaa1, Xaa2, Xaa3, and Xaa4 = Ala or Gly

<400> 105
Asp Phe Val Pro Xaa Glu Xaa Leu Glu Xaa Xaa Met 
 1               5                  10               

<210> 106
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antigenic Fragment

<400> 106
Leu Tyr Arg Glu Phe Asp 
 1               5            

<210> 107
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antigenic Fragment

<220> 
<221> VARIANT        
<222> 3

<223> Xaa = Any Amino Acid

<400> 107
Leu Tyr Xaa Glu Phe Asp 
 1               5            


<210> 108
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS4 Antigenic Fragment

<220> 
<221> VARIANT        
<222> 3

<223> Xaa = Ala or Gly

<400> 108
Leu Tyr Xaa Glu Phe Asp 
 1               5            

<210> 109
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antigenic Fragment

<400> 109
Pro Leu Glu Gly Glu Pro Gly Asp Pro Asp Leu 
 1               5                  10            

<210> 110
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antigenic Fragment

<220> 
<221> VARIANT        
<222> 7, 10

<223> Xaa = Any Amino Acid



<400> 110
Pro Leu Glu Gly Glu Pro Xaa Asp Pro Xaa Leu 
 1               5                  10            

<210> 111
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCV NS5 Antigenic Fragment

<220> 
<221> VARIANT        
<222> 7, 10

<223> Xaa1 and Xaa2 = Ala or Gly

<400> 111
Pro Leu Glu Gly Glu Pro Xaa Asp Pro Xaa Leu 
 1               5                  10            


 


1

