                         SEQUENCE LISTING

<110>  Medarex, Inc.
       King, David J.
       Witte, Alison
       LeBlanc, Heidi N.
       Theolis, Richard
       Masood , Asna
       Yamanaka, Mark
       Emory, Kyra D.
       Dwiggins, Sara R.
       Sproul, Tim
       Rao-Naik, Chetana
       Passmore, David
       
<120>  Human Antibodies That Bind CD22 And Uses Thereof

<130>  077375.0549

<150>  US 60/868,231
<151>  2006-12-01

<160>  128   

<170>  PatentIn version 3.4

<210>  1
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Tyr Ala Met Asn 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Tyr Tyr Trp Ser 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Tyr Trp Ile Gly 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Tyr Gly Ile Asn 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  5

Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  7
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  7

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Phe Tyr Tyr Tyr Phe Gly Met Asp Val 
1               5                   10  


<210>  10
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Phe Tyr Asp Ile Leu Thr Gly Tyr Tyr Pro Leu Gly Tyr 
1               5                   10                  


<210>  11
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  11

Pro Thr Tyr Tyr Phe Gly Ser Val Ala Phe Asp Ile 
1               5                   10          


<210>  12
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Gln Gly Val Val Val Val Ala Ala Thr His Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  13
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  13

Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Leu Val Ser 
1               5                   10                  


<210>  14
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  15
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  16
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  16

Arg Ala Ser Gln Ser Ile Gly Ser Ser Leu His 
1               5                   10      


<210>  17
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  18
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Ala Ser Gln Ser Val Ser Asn Phe Leu Ala 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Val Ser Lys Arg Pro Ser 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  22

Tyr Ala Ser Gln Ser Phe Ser 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  25
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  25

Cys Ser Tyr Ala Asn Ser Ser Thr Leu Val 
1               5                   10  


<210>  26
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Gln Arg Ser Asn Trp Pro Thr 
1               5               


<210>  27
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Gln Tyr Gly Ser Ser Pro Pro Thr 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

His Gln Ser Ser Ser Leu Pro Tyr Thr 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Gln Arg Ser Asn Trp Pro Trp Thr 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Gln Arg Ser Asn Trp Pro Pro Thr 
1               5                   


<210>  31
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Phe Tyr Tyr Tyr Phe Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  32
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Arg Ser Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Thr Phe Tyr Asp Ile Leu Thr Gly Tyr Tyr Pro Leu Gly Tyr Trp 
            100                 105                 110         


Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  33
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Asn Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Thr Tyr Tyr Phe Gly Ser Val Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  34
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Thr Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Val Val Val Val Ala Ala Thr His Tyr Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  35
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Leu His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Asn Ser 
                85                  90                  95      


Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  36
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  36

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  37
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  37

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  38
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  39
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  40
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  40

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  41
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  41
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt     60

tcctgcaagg cttctggata caccttcact agttatgcta tgaattgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcaacacca acactgggaa cccaacgtat    180

gcccagggct tcacaggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat    240

ctgcagatca gcagcctaaa ggctgaggac actgccgtgt attactgtgc taggttattc    300

tactactact tcggtatgga cgtctggggc caagggacca cggtcaccgt ctcctca       357


<210>  42
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  42
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtag gtccttcagt agttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggac atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg    240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcggg aacgttttac    300

gatattttga ctggttatta tccccttggg tactggggcc cgggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  43
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  43
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc     60

tcctgtaagg gttctggata caactttacc agctactgga tcggctgggt gcgccagatg    120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac    180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac    240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gaccccgacg    300

tattactttg gttcggtggc ttttgatatc tggggccaag ggacaatggt caccgtctct    360

tca                                                                  363


<210>  44
<211>  384
<212>  DNA
<213>  Homo sapiens

<400>  44
caggtccagc tggtgcagtc tggggctgag gtgaaaaaga ctgggtcctc ggtgaaggtc     60

tcctgcaagg cttctggagg caccttcagc agctatggta tcaactgggt gcgacaggcc    120

cctggacaag ggcttgaatg gatgggagag atcatcccta tctttggtac agcaaactac    180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagtctac    240

atggagctga gcagcctgag agctgaggac acggccgtgt attactgtgc gagagatcag    300

ggtgtagtgg tggtagctgc aacccactac tactactacg gtatggacgt ctggggccaa    360

gggaccacgg tcaccgtctc ctca                                           384


<210>  45
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  45
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc     60

tcctgcactg gaaccagcag tgatgttggg agttataacc ttgtctcctg gtaccaactg    120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtt    180

tctaatcgct tctctggctc caggtctggc aacacggcct ccctgacaat ctctgggctc    240

caggctgagg acgaggctga ttattactgc tgctcatatg caaatagtag cactttggta    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  46
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  46
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct    120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc    180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct    240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctacgtt cggccaaggg    300

accaaggtgg aaatcaaa                                                  318


<210>  47
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  47
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa    120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca    180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctcc gacgttcggc    300

caagggacca aggtggaaat caaa                                           324


<210>  48
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  48
gaaattgtgc tgactcagtc tccagacttt cagtctgtga ctccaaagga gaaagtcacc     60

atcacctgcc gggccagtca gagcattggt agtagcttac actggtacca gcagaaacca    120

gatcagtctc caaagctcct catcaagtat gcttcccagt ccttctcagg ggtcccctcg    180

aggttcagtg gcagtggatc tgggacagat ttcaccctca ccatcaatag cctggaagct    240

gaagatgctg cagcgtatta ctgtcatcag agtagtagtt taccgtacac ttttggccag    300

gggaccaagc tggagatcaa a                                              321


<210>  49
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  49
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct    120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc    180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct    240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa a                                              321


<210>  50
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  50
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc aacttcttag cctggtacca acagaaacct    120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc    180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct    240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccgac gttcggccaa    300

gggaccaagg tggaaatcaa a                                              321


<210>  51
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  52
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  53
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  53

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  54
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  55
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  55

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr 
        


<210>  56
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  56

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro 
                85                  90                  95  


<210>  57
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro 
    


<210>  58
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  58

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro 
                85                  90                  95  


<210>  59
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  59

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 
                325                 330                 335     


Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 
            340                 345                 350         


Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 
        355                 360                 365             


Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 
    370                 375                 380                 


Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 
385                 390                 395                 400 


Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 
                405                 410                 415     


Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 
            420                 425                 430         


Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 
        435                 440                 445             


Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 
    450                 455                 460                 


Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 
465                 470                 475                 480 


Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 
                485                 490                 495     


Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 
            500                 505                 510         


Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 
        515                 520                 525             


Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 
    530                 535                 540                 


Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 
545                 550                 555                 560 


Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 
                565                 570                 575     


Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 
            580                 585                 590         


Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 
        595                 600                 605             


Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 
    610                 615                 620                 


Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 
625                 630                 635                 640 


Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 
                645                 650                 655     


Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 
            660                 665                 670         


Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 
        675                 680                 685             


Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 
    690                 695                 700                 


Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 
705                 710                 715                 720 


Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 
                725                 730                 735     


Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr 
            740                 745                 750         


Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro 
        755                 760                 765             


Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln 
    770                 775                 780                 


Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His 
785                 790                 795                 800 


Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu 
                805                 810                 815     


Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu 
            820                 825                 830         


Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
        835                 840                 845         


<210>  60
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  60

Asp Ile Gln His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  61
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  61

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Arg Ser Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Gln His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Thr Phe Tyr Asp Ile Leu Thr Gly Tyr Tyr Pro Leu Gly Tyr Trp 
            100                 105                 110         


Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  62
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  62
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtag gtccttcagt agttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggac atccaacata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg    240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcggg aacgttttac    300

gatattttga ctggttatta tccccttggg tactggggcc cgggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  63
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  63

Asn Tyr Ala Ile Ser 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  64

Gly His Tyr Trp Ser 
1               5   


<210>  65
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  65

Gly His Tyr Trp Ser 
1               5   


<210>  66
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  66

Arg Ile Ile Pro Ile Leu Gly Met Ala Ile Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  67

Glu Thr Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  68
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  68

Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  69
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  69

Ala Pro Thr Tyr Trp Gly Ser Lys Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  70
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  70

Thr Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Pro Phe Asp Ser 
1               5                   10                  


<210>  71
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  71

Thr Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Pro Phe Asp Ser Trp Gly 
1               5                   10                  15      


Gln Gly Thr Leu Val Thr Val Ser Ser 
            20                  25  


<210>  72
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  72

Arg Ala Ser Gln Asp Ile Ser Ser Gly Leu Ala 
1               5                   10      


<210>  73
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  73

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  74
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  74

Arg Ala Ser Gln Ser Val Ser Gly Tyr Leu Ala 
1               5                   10      


<210>  75
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  75

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  76
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  76

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  77
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  77

Asp Val Ser Tyr Arg Ala Thr 
1               5           


<210>  78
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  78

Gln Gln Phe Asn Ser Phe Pro Tyr Thr 
1               5                   


<210>  79
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  79

Gln Gln Tyr Gly Ser Ser Pro Thr 
1               5               


<210>  80
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  80

Gln Gln Arg Ser Asn Trp Pro Ile Thr 
1               5                   


<210>  81
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  81

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser Gly Asp Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Met Ala Ile Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Phe 
65                  70                  75                  80  


Met Asp Leu Thr Ser Leu Tyr Phe Glu Asp Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Pro Thr Tyr Trp Gly Ser Lys Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  82
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  82

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly His 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Thr Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Pro Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  83
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  83

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly His 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Pro Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  84
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  84

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  85
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  85

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  86
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  86

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Val Ser Tyr Arg Ala Thr Gly Ile Leu Val Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  87
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  87
caggtccagt tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc     60

tcctgcaagc cttctggaga caccttcagc aactatgcta tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat ggctatctac    180

gcaccgaagt tccagggcag agttacgatt accgcggaca aatccacgaa cacagccttc    240

atggatctta ccagcctgta ttttgaggac acggccgtgt attactgtgc gagagcccca    300

acttactggg gatcgaagga ctactttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  88
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  88
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggtcactact ggagctggat ccgccagtcc    120

ccagggaagg ggctggagtg gattggggaa accgatcata gtggaagcac caactacaat    180

ccgtccctca agagtcgagt caccatatca atagacacgt ccaagaatca gttctccctg    240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag gacgtattac    300

gatattttga ctgattatta cccctttgac tcctggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  89
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  89
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggtcactact ggagctggat ccgccagtcc    120

ccagggaagg gactggagtg gattggggaa atcgatcata gtggaagcac caactacaat    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg    240

aagctgagct ctgtgaccgc cgcggacacg gctatgtatt actgtgcgag gacgtattac    300

gatattttga ctgattatta cccctttgac tcctggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  90
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  90
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca ggacattagc agtggtttag cctggtatca gcagaaacca    120

gggacagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gacgattttg caacttatta ctgtcaacag tttaatagtt tcccgtacac ttttggccag    300

gggaccaagc tggagatcaa a                                              321


<210>  91
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  91
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa    120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca    180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacccac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  92
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  92
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc ggctacttag cctggtacca acagaaacct    120

ggccaggctc ccaggctcct catctatgat gtatcctaca gggccactgg catcctagtc    180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct    240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcccatcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  93
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  93

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser 
                85                  90              


<210>  94
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  94

Ala Leu Ala Leu 
1               


<210>  95
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  95

Ala Leu Ala Leu 
1               


<210>  96
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  96

Gly Phe Leu Gly 
1               


<210>  97
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  97

Leu Leu Gly Leu 
1               


<210>  98
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Tryptase substrate

<400>  98

Pro Arg Phe Lys 
1               


<210>  99
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Tryptase substrate

<400>  99

Thr Arg Leu Arg 
1               


<210>  100
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  tryptase substrate

<400>  100

Ser Lys Gly Arg 
1               


<210>  101
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Tryptase substrate

<400>  101

Pro Asn Asp Lys 
1               


<210>  102
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Tryptase substrate

<400>  102

Pro Val Gly Leu Ile Gly 
1               5       


<210>  103
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Tryptase substrate

<400>  103

Gly Pro Leu Gly Val 
1               5   


<210>  104
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Tryptase substrate

<400>  104

Gly Pro Leu Gly Ile Ala Gly Gln 
1               5               


<210>  105
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Tryptase substrate

<400>  105

Pro Leu Gly Leu 
1               


<210>  106
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Tryptase substrate

<400>  106

Gly Pro Leu Gly Met Leu Ser Gln 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Tryptase substrate

<400>  107

Gly Pro Leu Gly Leu Trp Ala Gln 
1               5               


<210>  108
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  108

Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
1               5                   10                  15      


Val Ser Ser 
            


<210>  109
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  109

Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10          


<210>  110
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  110

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10      


<210>  111
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  111

Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10              


<210>  112
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  112

Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10                  15  


<210>  113
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  113

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10      


<210>  114
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  114

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10          


<210>  115
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  115

Asp Ile Val Val Val Val Ala Ala Thr 
1               5                   


<210>  116
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  116

Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  117
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  117

Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10              


<210>  118
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  118

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  119
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  119

Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  


<210>  120
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  120

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  121
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  121

Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  


<210>  122
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  122

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro 
                85                  90                  95  


<210>  123
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  123

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10      


<210>  124
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  124

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  125
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  125

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15  


<210>  126
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  126

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10          


<210>  127
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  127

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


<210>  128
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  128

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10      


