                         SEQUENCE LISTING

<110>  University of Maryland Biotechnology Institute
       Belas, Robert
       Geng, Haifeng
 
<120>  BIOSYNTHETIC PATHWAY AND GENES REQUIRED FOR TROPODITHIETIC ACID 
       BIOSYNTHESIS IN SILICIBACTER TM1040

<130>  4115-248 PCT

<141>  2007-11-27

<150>  US 60/861117
<151>  2006-11-27

<160>  10    

<170>  PatentIn version 3.3

<210>  1
<211>  5844
<212>  DNA
<213>  silicibacter

<400>  1
gccccccggg ggggggcccg ggccaggtaa attcgcccgg ggttttacgg gggggttttt     60

tttcccgaaa ggatgacgca aaattccacc cagtttcctg gccccggaaa tagaagcccc    120

ccggttcggg gggtgaactc ggggggaggg ggcctttgcc catcccagat gcagcttgcg    180

cagataggcc gtcggttgac cccccaagag ccaagccgcc tcgccgggag gtgaacttgc    240

gctccccttg gcgctcgggg ggaaaggagg ctttcgcgtt gattgtgcaa tgtgcgccca    300

gccattcgaa atgctcccga ataagctggt tgagatcctc atgcagcgct tctgctgctg    360

ccggagcctt ggtcgttgca tgccgtcctg cccttcgtat cctctgtgac ggttccactg    420

tgacggtggc gatggcgcaa ggagccgcct cagatcgggc gttttctctt cagcctgccc    480

gccgtgttca cggaaatcga cgtttttgta tctttccgtg actatttacc gccgagcggg    540

attcgtgcaa gggttttctg cccaagttat ccacaggatg cgcaattttt gagccccgca    600

gacgcggtga tggcctctgg gggcggagaa gttgcctgtc atacccgtga cacgagacta    660

aaggcattct gcaatagcca gccgcccagt ccggtctctc tgtgaccttt ggcatccggg    720

acggcgccgc caaaccggcc ccatgtcagc gccgcattgc gggaaacgcc agggcgcaga    780

agacccgaag acggcccgca aaccgccgga tgccgcgtgg gacaggggcg ggacaggatg    840

gagaaccgtg gtggcctcgc cctttctggc gagggatttt cgcgcgtaac ccgtgtggcg    900

aaaccccgcc gaagcgcgta agtctcagaa aaaatgacta aattatcggc ttgataaaat    960

ctgtagacga cataacctat aggagattcg tttgccagtg ttttaccctt ggttgttgag   1020

ggcacattaa taagaccgcg gttccggcca gctattgacc gccgccgttg cagaccccct   1080

gcaatgcgcg ccgtccagcg agagagaccg actttcccaa aacccaaccc aagaccagat   1140

atggtgcact gtgcgtcatc agtgagtggg agcgagatta gatttggaca ttcaacagct   1200

aagagtcttt gtcaccgttg caaaacatgg cagcatcacc cgtgcttctg acattctgtg   1260

gcagccagcc ctcggtgagc gcgcagatca agagcctgga gacgacactc gggatcacgc   1320

tgtttgagcg cacctcgcgg ggcatggtgg tcacgcaggg gggcgagcgc cttctggatg   1380

aggcgaccgc ttgtggatcg gcacaaacag ttcatgcagg aggcctcgcg actgaagggc   1440

agtgtctcgg ggctgtttgc catgggcgca gggcggcatt cgggcaacgg ctttgtcagc   1500

tctttcctgc attgtctcgg aacgctttcc ggaactggag atcgagctca aacacctggc   1560

ctcggcgcag gtgatcgagg ggctgcgcga tcagtcgctg gacatgggat ttttcaccga   1620

aaccgaaagc gacacctcga ttgacgctgg tggaggtggc cagtttcggc atctaccttg   1680

cggcgccgcg cgggatgatc cgttgttcag agacccctga ctgggcgcgt cttcaggatc   1740

agatctggat tgtctcgtct catgtggcgc tgcggtcgct gggccaatgc cctcatggag   1800

cagcatgaca ttcgcccaag gcgggtgatc aaggttgatg acgaggcggt gacgcggacg   1860

ctggtggcaa gcggagccgg ggtcgggctg tgcattctcg ggtgatgaag cgctgacgcc   1920

gcccgatgac atcgacctgt tgcaccgggt gcgcaagacc gcgcggatca tgtgcggcta   1980

tctcgaagcg cgcagcgatg atccctctat tcgcgcgtag ataattggtt ctggatttgc   2040

tgaaatctca acaaaaaggc gaaacaccct ccttgttgca attggcgtaa tcacaatttc   2100

atttgagaat ccccaaataa gggaatacgt cattcgagag tgttattttg gagttgtcat   2160

gattacgatt tatagcctct gtggcaaaga cgatattcat tattccccgc atgtttggaa   2220

agtcattatg gccctgcatc acaaagggct ttcatttgac gtggtgccgt ggattttcga   2280

cgatccgcga catcgagggc ggggcgttca acagcgtgcc ggtgctgcgc gatggcgacc   2340

gggtgatcgg ggacagcttc gagatctgca cctatctgga tgccgcctac ccggtgcccc   2400

ggcctgtttg ccggtgcggg cagtgaggcg caggtgcggt tcctggaaag ctattgcctg   2460

acggcgctgc acccaccgct cgcggtgatc gcggtgatgg cgatgcatga catcatgcat   2520

cgggcgatca gcctatttcc gggccaaacg cgaagagcgt tttggcgtgt ccatcgaggc   2580

gctggcggaa accgcgcccg ccgagcgcgc gcgattgcag gagcggctgg cgccggtgcg   2640

cgccgtctta cgcatcacac tggcttgcgg gcgatgcccc ggcgatggcc gattacgtgg   2700

tgttcagcgc cttgcagtgg tgctgggtcg tggggctgcg cgatcttctg tcccccgacg   2760

attcggtggc gcgtggttca gccgtgtcag gccctgtttg gaggggcggc gcaaaagcct   2820

gctggagccc cgcgctaagc ctgagctgaa tctgcgcgaa caaaccggca aaacccggcc   2880

caaattcatc tgatgcgccc ccgatcgggg ccgctttttg ttggttttgg ggcatttacg   2940

gctgtgtcac caaagccgat agctgacctc agtttttccg aattgcgaca aagcgcgtca   3000

ttggatcata tgagtcccaa ggttcgatac gtcctgagcg aattgatttt tgaaacggtt   3060

ggaaatgaac aagtaaatgg ttgcgtatcc gaaattgaat ttcagtcaat tgatgatgcc   3120

attggaggac tcttgaatgg acgtcgcgct atggacggtc ccagaaccaa cgcagtgaag   3180

acatatccaa aacctatgac tggggtgcgc catgttcata ccctgggacc ggctggcacc   3240

aactgtgaaa aggcggcgct gaaatgggcg gcgctcagtg ccgcaatgct gcctggtcct   3300

gcatgactcg atggaggagg ccgcagagca ggtcgcggcc tgcggctgtt cggtgcttct   3360

gagcgtggtg gcctacccgc agctgcattc gatcatctac gacatatcgc gcatctgggc   3420

ttctggatgt gttcatcatg aagaccgacg acatggtgct ggcctcggtg agcggcgcca   3480

tgccgacgct gtgccagacc cacccggcgc cggaaaagct gctgccgccc gagatgcagc   3540

ggatctatgc gacgagcaat tcccacgcgg cctctgaggt ggcggcaggg cggggcgatg   3600

gctgcatcac cacgcgtgcc gccgccgaag cacgggcttt tggtggtgca gacctttggc   3660

caggtgccga tggggttcac cattcacggc ccgctcaagc atgcgggctg cgcggacacc   3720

gcctttgacg tttcagcacc agatcacaac aggattttcc caatgaccca acgcgcattt   3780

gagacccgga tcgaagtccg ctaccgcgac accgactcga tgggccatat cagcagcccg   3840

atctactacg actacatgca gtcggcctat ctggaataca gccgcgctgc tggagctgcc   3900

gaagtccgaa aagctgccgc atatcatggt gaaaaccgcc tgcgagtaca tcagccaggc   3960

ctattacggc gataccgtgg tggtgctgag caaagtgtcg aaattcgcgc aagagtttcg   4020

agatcgacca tgagatccgc cttggcagcg cggacggccg ggtggtggca aagctacagt   4080

cggtgcatgt gatgttcgat tacgaaaagc agagcaccta cccggttccg gagatttcgc   4140

agccgcgtcg ccgattttca ggacgccgcc tgagcgcgcg ccacggtcca gagagggaga   4200

atgcaatgga tttgagttgg agcacgcagc agcagtcgat ccgggcggag tttgcctcct   4260

cggagccgca cagaccgcga tgagctgcgt cttggacggc gcgcctttga ccagcagacc   4320

tgggatcagc tgggagaggc gggcctgtgg cagatgatgg tgccaaagga ctatggtggc   4380

accggggcgg accggggctt gctggtggga tgtcaccgcc gcccttgagg ggctggcctc   4440

gaccatccgc gcgccggggc tgttgctgtc ggtgatcgcc caagcgggta tggcctacgc   4500

gctggagctc ttggcacccg gcgcagaaat ccgactattt ccgccgcatc ctgcgcggcg   4560

cgctgagcgc cacggccatc gcggaccccg acaccggcac cgatgtccgc gccagctcca   4620

cttacctcag cccgcgccga acgaaccttt gtgctcaacg ggaagaaata caacatcgcc   4680

catgcgccgg tggcgaattt cactctggtg gtctgcaagc tcgaaggcca tgcccgcgac   4740

ggcatctccc tggttctggt ggtcaggaca gaagggcgtc accatcggtg ccaaggatcg   4800

caagcttgga aacctagatt tgccgacggg ggcgctctcg tttgagaatg tgccgctgca   4860

ctatgggcat attctggggg tgccgggcaa gggctgcgaa ccttgtgcgg tttgtctcgc   4920

tggggcggat ctattacggg ctggtggcgg cgaccctgtg cggcccgatg cttgcggagg   4980

cgctgtctta tgccaaggcc cggcagacct ttggcagccc atcgtgatca ccagtatgtg   5040

cagaagaaac tgaccgatat gcgcatcgcg gcagagaccg ccaaatggac ctcttatggg   5100

gcgttgcacc agttgctgag cggcgcgccc gaggcggtga gagctgttcg atgccaagct   5160

ggccggagcc agcgcgatca ccgatggggc cgtggacctg ctgaaactat acggcagccg   5220

gggctatcac gtagggcgag gtgtccacgt tcctgcgcga tgcgctgcct tttgcagcgt   5280

ggcggcaccg aggaaatgca tcggcgcaac atcatgaacc agatgatgcg agaggcccgc   5340

ccggccaagt ccaagcccgc cgccccggcg cgggatctgg aaaccgtctg aggccgcctt   5400

tattgattgg agacaatcat gttaaaagat ttcaacagct tgcgctgtct cgcgcatggt   5460

gctgcactag gcgctgtact gggcgcgatg ccgcttgcgg cgggtgccgc agaagaggga   5520

tcctgagcga ggccagatcg actgggccgc cgcagaggac tcggcggtgg caaccgctac   5580

agcagaagcc gcactcacgg aggcgtttct ggccctgccc gcgagcgccg agcccaccgg   5640

tttgcggtga tgctctttgg gcggcggcgg atctgcccga gccgggcttt gtcagtcagg   5700

gcagcgccta tgtggcctat tacgcgcagg acgatattca gctttcgatc tcggggtcaa   5760

aggcggtggt caggcggggg atgcgctgtt ctgcaccatg ccccaagcgc gtgggaaagc   5820

atcggaacgg gcgcggatta caat                                          5844


<210>  2
<211>  2501
<212>  DNA
<213>  silicibacter

<400>  2
gcgccggtgg agagaacaaa catcctcgcg gcttgctgga gttctacctc gaggaagcga     60

gatcacggcc cgccacctgc tgacacaagt ctcggtatct gagtcgaagg tgtgccggtg    120

cgcgagggaa cacccgtttc gcaaaccgct ctcccggctc agggtggggg atcacctgcg    180

cagcgccgac cgcatcgtgc ggccgaggac gtcgaagcct ttggccacct cacgggcgat    240

ctgttttatg cccttggacg aggccgccgc gcgcaatcat ccgttctttg acgggcgcgt    300

cgcgcatggg caatacatca tggcgctggc caacggcctc tttgtggacc ccgagcccgg    360

ccccgtgctg gccaatctcg ccccgcgatc tgcgtttttt tgcgccggtc tatttcgaca    420

ccgcgctcta tgtgacgctc acctgctgct gcatcggccc cctcaacagg tcgggcgcgg    480

ccgaagtgca atggagctgc caggtcgggc agcgatgacg acacccgcgt ggcccagttc    540

gacctgctga cccttgtcgc cgcccaatgg ccgccccagc ccgccccccg cgcctgagag    600

gcccgagagg cctgagacgc cgggtacgcc aatgcccctt cccctgctat tgaaacaaaa    660

ggatttccaa tgacctctgc tccaaagccc cgcatcctga tcggtgcctg cggctcgctc    720

gacctgctga tgctgccgca gcacctgcgc gccatcagga cacatcgact gcacgctgag    780

cctgatgctc acgccgacgg cggtgaaatt tgtcaacacg gatgcgctgg ccctgctggt    840

ggaccggctg atccacggcg accgccccga cgactggcca cgcacaagcc ggacgccttg    900

ccgccgatca cgatcttctt gcggtgctgc cgacaaccgc aaacaccctc agtgccgtgg    960

ccaacggcag ctcgcagaac cgcctcacca cggtgatcct cgcagcggat ttccggactg   1020

ttctttcccg tgatgggcgg gccgatgtgg gacaaggcct cggtgcagcg caatgtgagc   1080

cagatccgcg ccgacgggta tgaggtgttt cagccggtct ggcgcgaaca cagcgcccgc   1140

atcgcaaaag gtccacggcc atcattcgct gccggacccc gcggatgtgg tcgacatcct   1200

ccaaagccgc ctgcccgcgc agcgctgacc cggcctaccc gcctgccccc cctgccccac   1260

agatctgtcc aaacaggaaa cgccgccgga tctcctccgg cggcgtttct cgtggtctct   1320

ttgcctttgg ccctagccgg tcacatcacg caggccgggg cgcagcatgg gccacagccg   1380

cgcctgccca gcgccgcaga tagagcccca ccccaaagga gagatgcgtc atcgcgctct   1440

tcagctgcgc aaaggtcgga tcgggcttgt tgctggccat gatgcccgca cccatcgccg   1500

gctgcatcac aaaaagggaa agacatggtg ccgagcccca ccacaagcgc cagcaacacc   1560

tgcggccgtt gcagctgccc gacgcccccg atcgccacaa agagcgccgc aaagaccacg   1620

cccaccgcat aatgtaccgc cagccaagcg cgcctcaccc gccaccggcg ccgccgcgcg   1680

aatgctctca tgggcgaaca cgccctcggg catatggccg acccaacgcc ccaccagggc   1740

aaagttgctc tgcggaatcg caaacagcgc ctccgccagc acggcccaga gatccatcac   1800

caccgtggca cccacgccca agcagtacgc gaaaaacaat ctgtgcagga gacatcctga   1860

gaaccctctc tctcgctcac aggcgccagc cgcctggcca gccccttttg aagatgcgcc   1920

cgacccatca aaatgcgggc cgggcggtac gcgttacgcc ctttactggg acaccatcgt   1980

gctatcgaac ccggcacagg tctggggcgc ggcggcctcg gcgctgaggg gttgtagcgc   2040

ggttgcagcg acgtgatgcc cgatctggta gccacatatc gcccaccgcg ttcgagcgcc   2100

ggtaatgcac gccgccaatc aggcgcgatt ccgattcctc ttcggcgagg tgctgcagac   2160

tgtcgtaaga cttgctgatg ttggcggccc cctcaaaggg acgggaaagg cgcgctgcca   2220

aagaccgagg tcatcacctc aagcgctgcg ctgccgctgg tgcaatgctg acaggggtat   2280

tcgggatgca tcggcgcagg aatgcgcgat tcccagacca gaccggctca ggtcggggtg   2340

gttgtaggtt ttgcccaacg cctccacggc ggtctgtggc cgccagagcg cgtagctgta   2400

cttggcgttg aacccggcca ccaacgcatc gctcagggcg acattcaaca cgccacatgc   2460

gcgtttcctc gagaagaggc agcgcgccag gccgcgcaga g                       2501


<210>  3
<211>  934
<212>  DNA
<213>  silicibacter

<400>  3
gaattcgccc gccttgatcg cggcgcgcac ctcttccatc ggggcgatgg cctcttcggg     60

caccatcgac gcggtaaagg agatgtcgtt gccgccctct ttcatgaggc caaagcgggt    120

gtagtccccc gctggaattg cccgccgcgc gatccgccag cgccgcccca aggatggggc    180

caaagttcca gatcgcattc gagaacacgg tctcggggta gcgctcggta taatcggtga    240

gcgagcccac cgctgatgcc gcgttccttg gcggcgtcgg cggtgccgat ccgctcgcca    300

aagaggatgt cggcgccgga atcgatctgc gccagaccgg cctcgcgggc cttgggcgga    360

tcaaagaagg tgccgataag tgatgagatg ggtcgcatcg ggacgcaccg cgtcgacacc    420

ctgacggaac ccgttgatga gcatgttgac ctcggggatc gggatcgccc ccaccgcgcc    480

aaagacgccg gactggctca tcttgccgca gcatgccgca cagataggcc gcctcgtggt    540

tccaggtgcc aaaggtgcca aagttgtcgc ccgcgggctt gccgctggag cccatcacga    600

agcgcgtgtc gggatagtcg cccgccacct gcgcgctcgc gctccaccgc ataggcttcg    660

cccacgatca catccgcgcc ctgctcggca tattcacgca tcgcgcgcgc atagtcggtg    720

cccgcgatcc cctcggaaaa gacatattcg atctcgcgcg cttgccgctt cgagcatcgc    780

cacatgcaga cgcgagttcc acgcgttctc caccggcgag gcatgcaccc ctgccacctt    840

gatcggcgct tgcgccagca ccatcggcgc cggcagcaac gaggccgccc caagtgctgc    900

gccgctcttc aggatcgatc ttcgggttca tacc                                934


<210>  4
<211>  687
<212>  DNA
<213>  silicibacter

<400>  4
gaattcctcg gcgcggacat cctctgccag catttcgatc tcttgcgcac gcagccgcag     60

gggagagaga tcaaagccat aggcgacctt ctcggtgcca tagcgccgcg catagcgttt    120

gccattggct gtcgcgtctg agcagcaaac cggcctcgac caggcgggcg agatagcggc    180

gcatggtgga attggccatg ccgttgagcc gctcgcagat gctctggttc gaggggtgaa    240

tgacaaggtc gcgtcacggg cagctcggcc ccggaccaga agctcaagag cgcttgcagc    300

actgagagat cccggtcgct gaggccaaaa tgatgccggg cggtcgcgag atcgcgcagc    360

acattccact tgctgacagt gaagtgcggt cgtgggctga gacctcgggg cctcgggatc    420

ggtggatgcg gcaggcatac gggagctggc cgcctgaagc tgcgtctgac gtttgatcag    480

aacagcatca acggtgcgcc caaaagcgga caggatgata ccccatgttt cattcacgaa    540

gacaaagaaa tcccgttctg cgaatcacat ttgacttgca gtttcaggct cctgacacta    600

gcttgatggt gctaaacaca agtcagggtc tgtgggcgat gtctttgcgg gaccttttct    660

tttgtctgct cgtgcctcct ttcttag                                        687


<210>  5
<211>  24
<212>  DNA
<213>  silicibacter

<400>  5
cagatgatgg tgccaaagga ctat                                            24


<210>  6
<211>  25
<212>  DNA
<213>  silicibacter

<400>  6
ggtcagtttc ttctgcacat actgg                                           25


<210>  7
<211>  21
<212>  DNA
<213>  silicibacter

<400>  7
ttgcagtatc caatggtcgt g                                               21


<210>  8
<211>  21
<212>  DNA
<213>  silicibacter

<400>  8
tgaattgcgt cagagtttgc c                                               21


<210>  9
<211>  20
<212>  DNA
<213>  silicibacter

<400>  9
cgctttccgg aactggagat                                                 20


<210>  10
<211>  21
<212>  DNA
<213>  silicibacter

<400>  10
ggctgccgta tagtttcagc a                                               21


