                              Sequence Listing

<110> Genentech, Inc.
      Arnott,David
      Balazs, Mercedes
      Ghilardi, Nico
      Gurney,Austin
      Hass,Phillip
      Hymowitz, Sarah
      Lee,James
      Ouyang, Wenjun
      Starovasnik, Melissa
      Wu,Yan
      

<120> IL-17AF Heterologous Polypeptides and Therapeutic 
      Uses Therof

<130> 39766-0206-1R1P1.PCT

<140> Not yet Assigned
<141> Herewith

<150> 11/606,192
<151> 2006-11-29


<160> 80

<210> 1
<211> 12
<212> PRT
<213> Homo sapiens

<220>
<221> Unsure
<222> 10
<223> Unknown amino acid

<400> 1
 Gly Ile Thr Ile Pro Arg Asn Pro Gly Xaa Pro Asn
                   5                  10        

<210> 2
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2
 Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln
                   5                  10        

<210> 3
<211> 155
<212> PRT
<213> Homo sapiens

<400> 3
 Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu
   1               5                  10                  15

 Ser Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn
                  20                  25                  30

 Pro Gly Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val
                  35                  40                  45

 Met Val Asn Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro
                  50                  55                  60

 Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn
                  65                  70                  75

 Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp
                  80                  85                  90

 Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp Gly Asn
                  95                 100                 105

 Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile Leu
                 110                 115                 120

 Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu
                 125                 130                 135

 Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile
                 140                 145                 150

 Val His His Val Ala
                 155

<210> 4
<211> 163
<212> PRT
<213> Homo sapiens

<400> 4
 Met Thr Val Lys Thr Leu His Gly Pro Ala Met Val Lys Tyr Leu
   1               5                  10                  15

 Leu Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser Glu Ala Ala Ala
                  20                  25                  30

 Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu
                  35                  40                  45

 Ser Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly
                  50                  55                  60

 Ile Ile Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu
                  65                  70                  75

 Ser Arg Ser Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro
                  80                  85                  90

 Asn Arg Tyr Pro Ser Glu Val Val Gln Ala Gln Cys Arg Asn Leu
                  95                 100                 105

 Gly Cys Ile Asn Ala Gln Gly Lys Glu Asp Ile Ser Met Asn Ser
                 110                 115                 120

 Val Pro Ile Gln Gln Glu Thr Leu Val Val Arg Arg Lys His Gln
                 125                 130                 135

 Gly Cys Ser Val Ser Phe Gln Leu Glu Lys Val Leu Val Thr Val
                 140                 145                 150

 Gly Cys Thr Cys Val Thr Pro Val Ile His His Val Gln
                 155                 160            

<210> 5
<211> 1859
<212> DNA
<213> Homo sapiens

<400> 5
 gcaggcacaa actcatccat ccccagttga ttggaagaaa caacgatgac 50

 tcctgggaag acctcattgg tgtcactgct actgctgctg agcctggagg 100

 ccatagtgaa ggcaggaatc acaatcccac gaaatccagg atgcccaaat 150

 tctgaggaca agaacttccc ccggactgtg atggtcaacc tgaacatcca 200

 taaccggaat accaatacca atcccaaaag gtcctcagat tactacaacc 250

 gatccacctc accttggaat ctccaccgca atgaggaccc tgagagatat 300

 ccctctgtga tctgggaggc aaagtgccgc cacttgggct gcatcaacgc 350

 tgatgggaac gtggactacc acatgaactc tgtccccatc cagcaagaga 400

 tcctggtcct gcgcagggag cctccacact gccccaactc cttccggctg 450

 gagaagatac tggtgtccgt gggctgcacc tgtgtcaccc cgattgtcca 500

 ccatgtggcc taagagctct ggggagccca cactccccaa agcagttaga 550

 ctatggagag ccgacccagc ccctcaggaa ccctcatcct tcaaagacag 600

 cctcatttcg gactaaactc attagagttc ttaaggcagt ttgtccaatt 650

 aaagcttcag aggtaacact tggccaagat atgagatctg aattaccttt 700

 ccctctttcc aagaaggaag gtttgactga gtaccaattt gcttcttgtt 750

 tactttttta agggctttaa gttatttatg tatttaatat gccctgagat 800

 aactttgggg tataagattc cattttaatg aattacctac tttattttgt 850

 ttgtcttttt aaagaagata agattctggg cttgggaatt ttattattta 900

 aaaggtaaaa cctgtattta tttgagctat ttaaggatct atttatgttt 950

 aagtatttag aaaaaggtga aaaagcacta ttatcagttc tgcctaggta 1000

 aatgtaagat agaattaaat ggcagtgcaa aatttctgag tctttacaac 1050

 atacggatat agtatttcct cctctttgtt tttaaaagtt ataacatggc 1100

 tgaaaagaaa gattaaacct actttcatat gtattaattt aaattttgca 1150

 atttgttgag gttttacaag agatacagca agtctaactc tctgttccat 1200

 taaaccctta taataaaatc cttctgtaat aataaagttt caaaagaaaa 1250

 tgtttatttg ttctcattaa atgtatttta gcaaactcag ctcttcccta 1300

 ttgggaagag ttatgcaaat tctcctataa gcaaaacaaa gcatgtcttt 1350

 gagtaacaat gacctggaaa tacccaaaat tccaagttct cgatttcaca 1400

 tgccttcaag actgaacacc gactaaggtt ttcatactat tagccaatgc 1450

 tgtagacaga agcattttga taggaataga gcaaataaga taatggccct 1500

 gaggaatggc atgtcattat taaagatcat atggggaaaa tgaaaccctc 1550

 cccaaaatac aagaagttct gggaggagac attgtcttca gactacaatg 1600

 tccagtttct cccctagact caggcttcct ttggagatta aggcccctca 1650

 gagatcaaca gaccaacatt tttctcttcc tcaagcaaca ctcctagggc 1700

 ctggcttctg tctgatcaag gcaccacaca acccagaaag gagctgatgg 1750

 ggcagaacga actttaagta tgagaaaagt tcagcccaag taaaataaaa 1800

 actcaatcac attcaattcc agagtagttt caagtttcac atcgtaacca 1850

 ttttcgccc 1859

<210> 6
<211> 559
<212> DNA
<213> Homo sapiens

<400> 6
 caactgcacc tcggttctat cgatagccac cagcgcaaca tgacagtgaa 50

 gaccctgcat ggcccagcca tggtcaagta cttgctgctg tcgatattgg 100

 ggcttgcctt tctgagtgag gcggcagctc ggaaaatccc caaagtagga 150

 catacttttt tccaaaagcc tgagagttgc ccgcctgtgc caggaggtag 200

 tatgaagctt gacattggca tcatcaatga aaaccagcgc gtttccatgt 250

 cacgtaacat cgagagccgc tccacctccc cctggaatta cactgtcact 300

 tgggacccca accggtaccc ctcggaagtt gtacaggccc agtgtaggaa 350

 cttgggctgc atcaatgctc aaggaaagga agacatctcc atgaattccg 400

 ttcccatcca gcaagagacc ctggtcgtcc ggaggaagca ccaaggctgc 450

 tctgtttctt tccagttgga gaaggtgctg gtgactgttg gctgcacctg 500

 cgtcacccct gtcatccacc atgtgcagta agaggtgcat atccactcag 550

 ctgaagaag 559

<210> 7
<211> 21
<212> PRT
<213> Homo sapiens

<400> 7
 Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro Pro Val
   1               5                  10                  15

 Pro Gly Gly Ser Met Lys
                  20    

<210> 8
<211> 12
<212> PRT
<213> Homo sapiens

<400> 8
 His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu Lys
                   5                  10        

<210> 9
<211> 96
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 9
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Ser Ala Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Gly Ile Thr Pro Tyr Ser Gly Tyr Thr Asp Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Lys Glu Ala Arg Glu Gly Tyr Asp Val Gly Tyr Ala
                  80                  85                  90

 Met Asp Tyr Trp Gly Gln
                  95    

<210> 10
<211> 93
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 10
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Ser Tyr Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Glu Ile Ser Pro Pro Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Leu Leu Trp Trp Trp Asp Gly Ala Met Asp Tyr
                  80                  85                  90

 Trp Gly Gln
            

<210> 11
<211> 91
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 11
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Asn Thr Trp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Val Ile Thr Pro Tyr Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Glu Ser Met Trp Ser Lys Phe Asp Tyr Trp Gly
                  80                  85                  90

 Gln
    

<210> 12
<211> 96
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 12
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn Ser Ser Ala Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Tyr Ile Thr Pro Asp Asn Gly Asp Thr Asn Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Ile Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Gly His Gly Asn Phe Tyr Gly Thr Trp Ala Ala
                  80                  85                  90

 Met Asp Tyr Trp Gly Gln
                  95    

<210> 13
<211> 92
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 13
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Gly Ser Asp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Tyr Ile Asn Pro Tyr Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Ala Tyr Glu Met Trp Tyr Val Met Asp Tyr Trp
                  80                  85                  90

 Gly Gln
        

<210> 14
<211> 101
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 14
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Asn Ser Trp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Val Ile Thr Pro Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Glu Val Phe Pro Asp Ile Gly Asp Cys Ser Asn
                  80                  85                  90

 Ala Tyr Cys Tyr Ala Met Asp Tyr Trp Gly Gln
                  95                 100    

<210> 15
<211> 94
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 15
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Ser Thr Tyr Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Trp Ile Ser Pro Tyr Ser Gly Tyr Thr Asp Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Glu Val Gly Trp Gly Asp Ser Tyr Ala Met Asp
                  80                  85                  90

 Tyr Trp Gly Gln
                

<210> 16
<211> 99
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 16
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Gly Ser Trp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Gly Ile Tyr Pro Tyr Asp Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Glu Ala Glu Gly Leu Tyr Gln Ser Gly Ile Tyr
                  80                  85                  90

 Asp Ala Gly Met Asp Tyr Trp Gly Gln
                  95                

<210> 17
<211> 93
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 17
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Ser Tyr Tyr Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Trp Ile Tyr Pro Ala Asp Gly Ala Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Gly Ser Tyr Phe Gly Gly Tyr Asp Met Asp Tyr
                  80                  85                  90

 Trp Gly Gln
            

<210> 18
<211> 92
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 18
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn Asp Ser Asp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Ile Ile Tyr Pro Tyr Asp Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Ser Asn Leu Asp Asn Asn Leu Phe Asp Tyr Trp
                  80                  85                  90

 Gly Gln
        

<210> 19
<211> 98
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 19
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn Gly Tyr Trp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Asp Ile Asn Pro Asn Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Ala Tyr Arg Cys Gly Gly Leu Ala Asp Trp Ala
                  80                  85                  90

 Gly Ala Met Asp Tyr Trp Gly Gln
                  95            

<210> 20
<211> 98
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 20
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Gly Ser Trp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Ile Ile Thr Pro Ser Gly Gly Asn Thr Asp Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Glu Val Phe Ala Val Ser Thr Ala Gly Tyr Pro
                  80                  85                  90

 Trp Val Met Asp Tyr Trp Gly Gln
                  95            

<210> 21
<211> 96
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 21
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Asp Ser Trp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Ser Ile Thr Pro Tyr Asn Gly Asn Thr Asp Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Arg Gly Glu Ser Asp Glu Ala Tyr Ala Ala Val
                  80                  85                  90

 Met Asp Tyr Trp Gly Gln
                  95    

<210> 22
<211> 97
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 22
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ser Ser Asp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Thr Ile Asn Pro Ala Ser Gly Ser Thr Asp Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Gly Ala Asn Ser Ser Phe Tyr Ala Leu Gln Tyr
                  80                  85                  90

 Val Met Asp Tyr Trp Gly Gln
                  95        

<210> 23
<211> 98
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 23
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Asp Asn Tyr Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Trp Ile Ser Pro Tyr Ser Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Glu Thr Leu Phe Tyr Asp Lys Asp Gln Tyr Ser
                  80                  85                  90

 Tyr Val Met Asp Tyr Trp Gly Gln
                  95            

<210> 24
<211> 94
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 24
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ser Ser Tyr Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Trp Ile Ser Pro Tyr Ser Gly Tyr Thr Asp Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Glu Gly Leu Leu Arg Trp Gly Tyr Ala Met Asp
                  80                  85                  90

 Tyr Trp Gly Gln
                

<210> 25
<211> 96
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 25
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ser Ser Ala Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Gly Ile Thr Pro Ala Ser Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Ser Pro Gly Gly Val Phe Val Asp Gly Gly Val
                  80                  85                  90

 Met Asp Tyr Trp Gly Gln
                  95    

<210> 26
<211> 97
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 26
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Asn Thr Tyr Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Trp Ile Ser Pro Tyr Ser Gly Tyr Thr Asp Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Asp Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Glu Ile Leu Leu Asp Tyr Gly Ser Ala Gly Tyr
                  80                  85                  90

 Ala Met Asp Tyr Trp Gly Gln
                  95        

<210> 27
<211> 97
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 27
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Ser Thr Trp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Val Ile Thr Pro Thr Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Glu Val Trp Trp Trp Gly Asp Gly His Gly Tyr
                  80                  85                  90

 Val Met Asp Tyr Trp Gly Gln
                  95        

<210> 28
<211> 96
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 28
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ser Ser Ala Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Gly Ile Thr Pro Ala Ser Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Ser Pro Gly Gly Val Phe Val Asp Gly Gly Val
                  80                  85                  90

 Met Asp Tyr Trp Gly Gln
                  95    

<210> 29
<211> 101
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 29
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn Ser Thr Asp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Arg Ile Asn Pro Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Thr Ser Ala Tyr Thr Thr Trp Ala Val Asp Trp
                  80                  85                  90

 Phe Ile Gly Tyr Val Met Asp Tyr Trp Gly Gln
                  95                 100    

<210> 30
<211> 101
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 30
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Gly Tyr Gly Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Trp Ile Ser Pro Ser Asn Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Arg Val Ser Tyr Tyr Val Tyr Arg His Asp Trp
                  80                  85                  90

 Val Arg Gly Tyr Val Met Asp Tyr Trp Gly Gln
                  95                 100    

<210> 31
<211> 90
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 31
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Asp Thr Trp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Val Ile Thr Pro Tyr Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Asp Gly Gly Phe Phe Asp Asp Tyr Trp Gly Gln
                  80                  85                  90

<210> 32
<211> 94
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 32
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Ser Tyr Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Asp Ile Thr Pro Thr Asp Gly Tyr Thr Asp Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Asn Leu Met Trp Trp Asp Ser Ser Ala Met Asp
                  80                  85                  90

 Tyr Trp Gly Gln
                

<210> 33
<211> 101
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 33
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Gly Tyr Gly Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Trp Ile Ser Pro Ser Asn Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Tyr Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Arg Val Ser Tyr Tyr Val Tyr Arg His Asp Trp
                  80                  85                  90

 Val Arg Gly Tyr Val Met Asp Tyr Trp Gly Gln
                  95                 100    

<210> 34
<211> 96
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 34
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Gly Thr Tyr Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Trp Ile Ser Pro Tyr Ser Gly Tyr Thr Asn Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Glu Ala Arg Ser Ser Leu Ser Ala Asp Tyr Ala
                  80                  85                  90

 Met Asp Tyr Trp Gly Gln
                  95    

<210> 35
<211> 98
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 35
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Asp Asn Tyr Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Trp Ile Ser Pro Tyr Ser Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Glu Ser Gly Phe Ser Ala Cys Asn Thr Arg Ala
                  80                  85                  90

 Tyr Ala Met Asp Tyr Trp Gly Gln
                  95            

<210> 36
<211> 96
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 36
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Asp Ser Trp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Ser Ile Thr Pro Tyr Asn Gly Asn Thr Asp Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Arg Gly Glu Ser Asp Glu Ala Tyr Pro Ala Val
                  80                  85                  90

 Met Asp Tyr Trp Gly Gln
                  95    

<210> 37
<211> 94
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 37
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Ser Thr Ala Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Trp Ile Thr Pro Tyr Asp Gly Tyr Thr Asp Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Leu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Thr Trp Phe Thr Leu Ala Ser Ala Met Glu Leu
                  80                  85                  90

 Leu Gly Ser Ala
                

<210> 38
<211> 101
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 38
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Gly Asn Gly Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Trp Ile Ser Pro Thr Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Arg Val Asp Tyr Gln Val Tyr His Asp Arg Phe
                  80                  85                  90

 Glu Glu Gly Tyr Ala Met Asp Tyr Trp Gly Gln
                  95                 100    

<210> 39
<211> 94
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 39
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn Ser Tyr Trp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Trp Ile Ser Pro Asp Asn Gly Ala Thr Asn Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Lys Phe Trp Gly Trp Asp Trp Gly Gly Met Asp
                  80                  85                  90

 Tyr Trp Gly Gln
                

<210> 40
<211> 94
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 40
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Ser Tyr Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Asp Ile Thr Pro Thr Asp Gly Tyr Thr Asp Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Asn Leu Met Trp Trp Asp Ser Ser Ala Met Asp
                  80                  85                  90

 Tyr Trp Gly Gln
                

<210> 41
<211> 94
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 41
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Ser Gly Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
                  20                  25                  30

 Phe Ile Tyr Pro Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Met Ser Leu Ile Gly Phe Ser Tyr Ala Met Asp
                  80                  85                  90

 Tyr Trp Gly Gln
                

<210> 42
<211> 93
<212> PRT
<213> Artificial sequence

<220>
<223> synthetic polypeptides

<400> 42
 Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asn Ser Thr Trp Ile
   1               5                  10                  15

 His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
                  20                  25                  30

 Trp Ile Asn Pro Tyr Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val
                  35                  40                  45

 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                  50                  55                  60

 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                  65                  70                  75

 Tyr Cys Ala Arg Asp Leu Tyr Asp Tyr Asp Ile Gly Phe Asp Tyr
                  80                  85                  90

 Trp Gly Gln
            

<210> 43
<211> 288
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 43
 ttgtcctgtg cagcttctgg cttcaccatt agtgattccg ctatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct gggattactc 100

 cttatagcgg ttatactgac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgcaaaagag gcccgcgagg 250

 gctacgacgt cggctacgct atggactact  ggggtcaa 288

<210> 44
<211> 279
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 44
 ttgtcctgtg cagcttctgg cttcaccatt agtgattcct atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct gaaatttctc 100

 ctcctggcgg cgatacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtctc ttgtggtggt 250

 gggacggggc tatggactac  tggggtcaa 279

<210> 45
<211> 273
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 45
 ttgtcctgtg cagcttctgg cttcaccatt actaatactt ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct gttattactc 100

 cttatggcgg tgctacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgcaagagag agtatgtgga 250

 gtaagttcga ctactggggt  caa 273

<210> 46
<211> 288
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 46
 ttgtcctgtg cagcttctgg cttcaccatt aatagttctg ctatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt tatattactc 100

 ctgataacgg tgatactaac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aatagctgag gatactgccg tctattattg tgctcgcggc cacggcaact 250

 tctacggtac ctgggcggct atggactact  ggggtcaa 288

<210> 47
<211> 276
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 47
 ttgtcctgtg cagcttctgg cttcaccatt agtggttctg atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tatattaatc 100

 cttatggcgg ttctactgac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtgcg tacgagatgt 250

 ggtacgttat ggactactgg  ggtcaa 276

<210> 48
<211> 303
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 48
 ttgtcctgtg cagcttctgg cttcaccatt actaattcct ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt gttattactc 100

 cttctagcgg ttctacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtgag gtcttccccg 250

 acatcgggga ctgcagcaac gcctactgct acgctatgga ctactggggt 300

 caa 303

<210> 49
<211> 282
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 49
 ttgtcctgtg cagcttctgg cttcaccatt actagtactt atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tggatttctc 100

 cttatagcgg ttatactgac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtgag gtggggtggg 250

 gggactcgta cgctatggac tactggggtc  aa 282

<210> 50
<211> 297
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 50
 ttgtcctgtg cagcttctgg cttcaccatt agtggttctt ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct gggatttatc 100

 cttatgacgg ttatacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtgag gccgagggcc 250

 tgtaccagtc cgggatctac gacgcgggta tggactactg  gggtcaa 297

<210> 51
<211> 279
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 51
 ttgtcctgtg cagcttctgg cttcaccatt actagttact atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tggatttatc 100

 ctgctgacgg tgctacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtggg tcctacttcg 250

 ggggctacga tatggactac  tggggtcaa 279

<210> 52
<211> 276
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 52
 ttgtcctgtg cagcttctgg cttcaccatt aatgattctg atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt attatttatc 100

 cttatgacgg ttatacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgcaagaagc aacctggaca 250

 acaacttgtt cgactactgg  ggtcaa 276

<210> 53
<211> 294
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 53
 ttgtcctgtg cagcttctgg cttcaccatt aatggttact ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct gatattaatc 100

 ctaatggcgg ttctactaac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtgcc taccggtgcg 250

 gcgggctcgc cgactgggcc ggggctatgg actactgggg  tcaa 294

<210> 54
<211> 294
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 54
 ttgtcctgtg cagcttctgg cttcaccatt agtggttctt ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct attattactc 100

 cttctggcgg taatactgac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtgag gtcttcgccg 250

 tgtcgaccgc cggctacccc tgggttatgg actactgggg  tcaa 294

<210> 55
<211> 288
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 55
 ttgtcctgtg cagcttctgg cttcaccatt actgattctt ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt tctattactc 100

 cttataacgg taatactgac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgcagg ggggagtccg 250

 acgaggccta cgccgcggtt atggactact  ggggtcaa 288

<210> 56
<211> 291
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 56
 ttgtcctgtg cagcttctgg cttcaccatt agtagttccg atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt actattaatc 100

 ctgctagcgg ttctactgac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgcggc gccaacagca 250

 gcttctacgc gctccagtac gttatggact actggggtca  a 291

<210> 57
<211> 294
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 57
 ttgtcctgtg cagcttctgg cttcaccatt actgataatt atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt tggatttctc 100

 cttatagcgg ttatacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtgag accctcttct 250

 acgacaagga ccagtactcc tacgttatgg actactgggg  tcaa 294

<210> 58
<211> 282
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 58
 ttgtcctgtg cagcttctgg cttcaccatt agtagttctt atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tggatttctc 100

 cttatagcgg ttatactgac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtgag gggctcctgc 250

 ggtggggcta cgctatggac tactggggtc  aa 282

<210> 59
<211> 291
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 59
 ttgtcctgtg cagcttctgg cttcaccatt actgataatg ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt tggattactc 100

 ctactagcgg ttatactaac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgcgac ggggacacct 250

 ggaagtggga cgccccgtac gttatggact actggggtca  a 291

<210> 60
<211> 291
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 60
 ttgtcctgtg cagcttctgg cttcaccatt actaatactt atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tggatttctc 100

 cttatagcgg ttatactgac tatgccgata gcgtcaagga ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgcgag atcttgctgg 250

 actacggttc cgcgggctac gctatggact actggggtca  a 291

<210> 61
<211> 291
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 61
 ttgtcctgtg cagcttctgg cttcaccatt actagtacct ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt gttattactc 100

 ctactaacgg ttctacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgcgag gtgtggtggt 250

 ggggcgacgg ccacggctac gttatggact actggggtca  a 291

<210> 62
<211> 288
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 62
 ttgtcctgtg cagcttctgg cttcaccatt agtagttctg ctatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt gggattactc 100

 ctgctagcgg ttatacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgctcg cccggcgggg 250

 tgttcgtcga cggcggggtt atggactact  ggggtcaa 288

<210> 63
<211> 303
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 63
 ttgtcctgtg cagcttctgg cttcaccatt aatagtactg atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt aggattaatc 100

 cttctggcgg ttctactaac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtacc agcgcgtaca 250

 ccacgtgggc ggtcgactgg ttcatcggct acgttatgga ctactggggt 300

 caa 303

<210> 64
<211> 303
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 64
 ttgtcctgtg cagcttctgg cttcaccatt actggttacg ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tggatttctc 100

 cttctaacgg ttatacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtcgc gtcagctact 250

 acgtctacag gcacgactgg gtcaggggct acgttatgga ctactggggt 300

 caa 303

<210> 65
<211> 267
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 65
 ttgtcctgtg cagcttctgg cttcaccatt actgatacct ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt gttattactc 100

 cttatggcgg ttatacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgcaagagac gggggcttct 250

 tcgattactg  gggtcaa 267

<210> 66
<211> 282
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 66
 ttgtcctgtg cagcttctgg cttcaccatt agtgattcct ctatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tttatttatc 100

 ctactagcgg ttctacttac tatgccaata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgcacgtgcc tcgtacgggg 250

 tgagcaagtg gacctttgac tactggggtc  aa 282

<210> 67
<211> 303
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 67
 ttgtcctgtg cagcttctgg cttcaccatt actggttacg ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tggatttctc 100

 cttctaacgg ttatacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcat acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtcgc gtcagctact 250

 acgtctacag gcacgactgg gtcaggggct acgttatgga ctactggggt 300

 caa 303

<210> 68
<211> 288
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 68
 ttgtcctgtg cagcttctgg cttcaccatt actggtactt atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tggatttctc 100

 cttatagcgg ttatactaac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgcaagagag gcccgctcct 250

 cgttgagcgc ggactacgct atggactact  ggggtcaa 288

<210> 69
<211> 294
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 69
 ttgtcctgtg cagcttctgg cttcaccatt actgataatt atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tggatttctc 100

 cttatagcgg ttatacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtgag tccggcttct 250

 ccgcgtgcaa cacgcgggcg tacgctatgg actactgggg  tcaa 294

<210> 70
<211> 288
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 70
 ttgtcctgtg cagcttctgg cttcaccatt actgattctt ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt tctattactc 100

 cttataacgg taatactgac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgcagg ggggagtccg 250

 acgaggccta ccccgcggtt atggactact  ggggtcaa 288

<210> 71
<211> 280
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 71
 ttgtcctgtg cagcttctgg cttcaccatt actagtaccg ctatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tggattactc 100

 cttatgacgg ttatactgac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctactaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtacg tggttcacgc 250

 tggcctcggc tatggaacta ctggggtcaa 280

<210> 72
<211> 303
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 72
 ttgtcctgtg cagcttctgg cttcaccatt actggtaatg ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tggatttctc 100

 ctactaacgg ttctacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtagg gtcgactacc 250

 aggtctacca cgaccgcttc gaggaggggt acgctatgga ctactggggt 300

 caa 303

<210> 73
<211> 282
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 73
 ttgtcctgtg cagcttctgg cttcaccatt aatagttatt ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt tggatttctc 100

 ctgataacgg tgctactaac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtaag ttctggggct 250

 gggactgggg gggtatggac tactggggtc  aa 282

<210> 74
<211> 282
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 74
 ttgtcctgtg cagcttctgg cttcaccatt agtgattctt atatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt gatattactc 100

 ctactgacgg ttatactgac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtaac ttgatgtggt 250

 gggactcgtc ggctatggac tactggggtc  aa 282

<210> 75
<211> 282
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 75
 ttgtcctgtg cagcttctgg cttcaccatt agtgattctg ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttggt tttatttatc 100

 ctaatggcgg ttctacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgctcgtatg tcgttgatcg 250

 ggttctcgta cgctatggac tactggggtc  aa 282

<210> 76
<211> 279
<212> DNA
<213> Artificial sequence

<220>
<223> synthetic polynucleotides

<400> 76
 ttgtcctgtg cagcttctgg cttcaccatt aatagtacct ggatacactg 50

 ggtgcgtcag gccccgggta agggcctgga atgggttgct tggattaatc 100

 cttataacgg ttctacttac tatgccgata gcgtcaaggg ccgtttcact 150

 ataagcgcag acacatccaa aaacacagcc tacctacaaa tgaacagctt 200

 aagagctgag gacactgccg tctattattg tgcaagagac ttgtacgact 250

 acgacatcgg cttcgactac  tggggtcaa 279

<210> 77
<211> 133
<212> PRT
<213> Homo sapiens

<400> 77
 Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu
   1               5                  10                  15

 Ser Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly
                  20                  25                  30

 Ile Ile Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu
                  35                  40                  45

 Ser Arg Ser Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro
                  50                  55                  60

 Asn Arg Tyr Pro Ser Glu Val Val Gln Ala Gln Cys Arg Asn Leu
                  65                  70                  75

 Gly Cys Ile Asn Ala Gln Gly Lys Glu Asp Ile Ser Met Asn Ser
                  80                  85                  90

 Val Pro Ile Gln Gln Glu Thr Leu Val Val Arg Arg Lys His Gln
                  95                 100                 105

 Gly Cys Ser Val Ser Phe Gln Leu Glu Lys Val Leu Val Thr Val
                 110                 115                 120

 Gly Cys Thr Cys Val Thr Pro Val Ile His His Val Gln
                 125                 130            

<210> 78
<211> 132
<212> PRT
<213> Homo sapiens

<400> 78
 Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp
   1               5                  10                  15

 Lys Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn
                  20                  25                  30

 Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn
                  35                  40                  45

 Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu
                  50                  55                  60

 Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly
                  65                  70                  75

 Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser Val
                  80                  85                  90

 Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His
                  95                 100                 105

 Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly
                 110                 115                 120

 Cys Thr Cys Val Thr Pro Ile Val His His Val Ala
                 125                 130        

<210> 79
<211> 10
<212> PRT
<213> Homo sapiens

<400> 79
 Glu Pro Pro His Cys Pro Asn Ser Phe Arg
                   5                  10

<210> 80
<211> 10
<212> PRT
<213> Homo sapiens

<400> 80
 Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys
                   5                  10

