                         SEQUENCE LISTING

<110>  St. Jude Children's Research Hospital
       The University of North Carolina at Chapel Hill
       Potter, Philip M.
       Weirdl, Monika
       Redinbo, Matthew R.
 
<120>  COMPOSITIONS AND METHODS FOR INDUCING OR INHIBITING ACTIVITIES OF
        SELECTED HUMAN CELLS

<130>  SJ0048WO

<150>  US 60/805,643
<151>  2006-06-23

<160>  16    

<170>  PatentIn version 3.3

<210>  1
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Leu Arg Ala Phe Ile Leu Ala Thr Leu Ser Ala Ser Ala Ala 
1               5                   10                  15      


Trp Gly His Pro Ser Ser Pro Pro Val Val Asp Thr Val His Gly Lys 
            20                  25                  30          


Val Leu Gly Lys Phe Val Ser Leu Glu Gly Phe Ala Gln Pro Val Ala 
        35                  40                  45              


Ile Phe Leu Gly Ile Pro Phe Ala Lys Pro Pro Leu Gly Pro Leu Arg 
    50                  55                  60                  


Phe Thr Pro Pro Gln Pro Ala Glu Pro Trp Ser Phe Val Lys Asn Ala 
65                  70                  75                  80  


Thr Ser Tyr Pro Pro Met Cys Thr Gln Asp Pro Lys Ala Gly Gln Leu 
                85                  90                  95      


Leu Ser Glu Leu Phe Thr Asn Arg Lys Glu Asn Ile Pro Leu Lys Leu 
            100                 105                 110         


Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Thr Pro Ala Asp Leu Thr 
        115                 120                 125             


Lys Lys Asn Arg Leu Pro Val Met Val Trp Ile His Gly Gly Gly Leu 
    130                 135                 140                 


Met Val Gly Ala Ala Ser Thr Tyr Asp Gly Leu Ala Leu Ala Ala His 
145                 150                 155                 160 


Glu Asn Val Val Val Val Thr Ile Gln Tyr Arg Leu Gly Ile Trp Gly 
                165                 170                 175     


Phe Phe Ser Thr Gly Asp Glu His Ser Arg Gly Asn Trp Gly His Leu 
            180                 185                 190         


Asp Gln Val Ala Ala Leu Arg Trp Val Gln Asp Asn Ile Ala Ser Phe 
        195                 200                 205             


Gly Gly Asn Pro Gly Ser Val Thr Ile Phe Gly Glu Ser Ala Gly Gly 
    210                 215                 220                 


Glu Ser Val Ser Val Leu Val Leu Ser Pro Leu Ala Lys Asn Leu Phe 
225                 230                 235                 240 


His Arg Ala Ile Ser Glu Ser Gly Val Ala Leu Thr Ser Val Leu Val 
                245                 250                 255     


Lys Lys Gly Asp Val Lys Pro Leu Ala Glu Gln Ile Ala Ile Thr Ala 
            260                 265                 270         


Gly Cys Lys Thr Thr Thr Ser Ala Val Met Val His Cys Leu Arg Gln 
        275                 280                 285             


Lys Thr Glu Glu Glu Leu Leu Glu Thr Thr Leu Lys Met Lys Phe Leu 
    290                 295                 300                 


Ser Leu Asp Leu Gln Gly Asp Pro Arg Glu Ser Gln Pro Leu Leu Gly 
305                 310                 315                 320 


Thr Val Ile Asp Gly Met Leu Leu Leu Lys Thr Pro Glu Glu Leu Gln 
                325                 330                 335     


Ala Glu Arg Asn Phe His Thr Val Pro Tyr Met Val Gly Ile Asn Lys 
            340                 345                 350         


Gln Glu Phe Gly Trp Leu Ile Pro Met Leu Met Ser Tyr Pro Leu Ser 
        355                 360                 365             


Glu Gly Gln Leu Asp Gln Lys Thr Ala Met Ser Leu Leu Trp Lys Ser 
    370                 375                 380                 


Tyr Pro Leu Val Cys Ile Ala Lys Glu Leu Ile Pro Glu Ala Thr Glu 
385                 390                 395                 400 


Lys Tyr Leu Gly Gly Thr Asp Asp Thr Val Lys Lys Lys Asp Leu Phe 
                405                 410                 415     


Leu Asp Leu Ile Ala Asp Val Met Phe Gly Val Pro Ser Val Ile Val 
            420                 425                 430         


Ala Arg Asn His Arg Asp Ala Gly Ala Pro Thr Tyr Met Tyr Glu Phe 
        435                 440                 445             


Gln Tyr Arg Pro Ser Phe Ser Ser Asp Met Lys Pro Lys Thr Val Ile 
    450                 455                 460                 


Gly Asp His Gly Asp Glu Leu Phe Ser Val Phe Gly Ala Pro Phe Leu 
465                 470                 475                 480 


Lys Glu Gly Ala Ser Glu Glu Glu Ile Arg Leu Ser Lys Met Val Met 
                485                 490                 495     


Lys Phe Trp Ala Asn Phe Ala Arg Asn Gly Asn Pro Asn Gly Glu Gly 
            500                 505                 510         


Leu Pro His Trp Pro Glu Tyr Asn Gln Lys Glu Gly Tyr Leu Gln Ile 
        515                 520                 525             


Gly Ala Asn Thr Gln Ala Ala Gln Lys Leu Lys Asp Lys Glu Val Ala 
    530                 535                 540                 


Phe Trp Thr Asn Leu Phe Ala Lys Lys Ala Val Glu Lys Pro Pro Gln 
545                 550                 555                 560 


Thr Glu His Ile Glu Leu 
                565     


<210>  2
<211>  505
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  2

Gly Ser Leu Arg Phe Ala Pro Pro Gln Pro Ala Glu Ser Trp Ser His 
1               5                   10                  15      


Val Lys Asn Thr Thr Ser Tyr Pro Pro Met Cys Ser Gln Asp Ala Val 
            20                  25                  30          


Ser Gly His Met Leu Ser Glu Leu Phe Thr Asn Arg Lys Glu Asn Ile 
        35                  40                  45              


Pro Leu Lys Phe Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Thr Pro 
    50                  55                  60                  


Ala Asp Leu Thr Lys Arg Gly Arg Leu Pro Val Met Val Trp Ile His 
65                  70                  75                  80  


Gly Gly Gly Leu Met Val Gly Gly Ala Ser Thr Tyr Asp Gly Leu Ala 
                85                  90                  95      


Leu Ser Ala His Glu Asn Val Val Val Val Thr Ile Gln Tyr Arg Leu 
            100                 105                 110         


Gly Ile Trp Gly Phe Phe Ser Thr Gly Asp Glu His Ser Arg Gly Asn 
        115                 120                 125             


Trp Gly His Leu Asp Gln Val Ala Ala Leu Arg Trp Val Gln Asp Asn 
    130                 135                 140                 


Ile Ala Asn Phe Gly Gly Asp Pro Gly Ser Val Thr Ile Phe Gly Glu 
145                 150                 155                 160 


Ser Ala Gly Gly Gln Ser Val Ser Ile Leu Leu Leu Ser Pro Leu Thr 
                165                 170                 175     


Lys Asn Leu Phe His Arg Ala Ile Ser Glu Ser Gly Val Ala Leu Leu 
            180                 185                 190         


Ser Ser Leu Phe Arg Lys Asn Thr Lys Ser Leu Ala Glu Lys Ile Ala 
        195                 200                 205             


Ile Glu Ala Gly Cys Lys Thr Thr Thr Ser Ala Val Met Val His Cys 
    210                 215                 220                 


Leu Arg Gln Lys Thr Glu Glu Glu Leu Met Glu Val Thr Leu Lys Met 
225                 230                 235                 240 


Lys Phe Met Ala Leu Asp Leu Val Gly Asp Pro Lys Glu Asn Thr Ala 
                245                 250                 255     


Phe Leu Thr Thr Val Ile Asp Gly Val Leu Leu Pro Lys Ala Pro Ala 
            260                 265                 270         


Glu Ile Leu Ala Glu Lys Lys Tyr Asn Met Leu Pro Tyr Met Val Gly 
        275                 280                 285             


Ile Asn Gln Gln Glu Phe Gly Trp Ile Ile Pro Met Gln Met Leu Gly 
    290                 295                 300                 


Tyr Pro Leu Ser Glu Gly Lys Leu Asp Gln Lys Thr Ala Thr Glu Leu 
305                 310                 315                 320 


Leu Trp Lys Ser Tyr Pro Ile Val Asn Val Ser Lys Glu Leu Thr Pro 
                325                 330                 335     


Val Ala Thr Glu Lys Tyr Leu Gly Gly Thr Asp Asp Pro Val Lys Lys 
            340                 345                 350         


Lys Asp Leu Phe Leu Asp Met Leu Ala Asp Leu Leu Phe Gly Val Pro 
        355                 360                 365             


Ser Val Asn Val Ala Arg His His Arg Asp Ala Gly Ala Pro Thr Tyr 
    370                 375                 380                 


Met Tyr Glu Tyr Arg Tyr Arg Pro Ser Phe Ser Ser Asp Met Arg Pro 
385                 390                 395                 400 


Lys Thr Val Ile Gly Asp His Gly Asp Glu Ile Phe Ser Val Leu Gly 
                405                 410                 415     


Ala Pro Phe Leu Lys Glu Gly Ala Thr Glu Glu Glu Ile Lys Leu Ser 
            420                 425                 430         


Lys Met Val Met Lys Tyr Trp Ala Asn Phe Ala Arg Asn Gly Asn Pro 
        435                 440                 445             


Asn Gly Glu Gly Leu Pro Gln Trp Pro Ala Tyr Asp Tyr Lys Glu Gly 
    450                 455                 460                 


Tyr Leu Gln Ile Gly Ala Thr Thr Gln Ala Ala Gln Lys Leu Lys Asp 
465                 470                 475                 480 


Lys Glu Val Ala Phe Trp Thr Glu Leu Trp Ala Lys Glu Ala Ala Arg 
                485                 490                 495     


Pro Arg Glu Thr Glu His Ile Glu Leu 
            500                 505 


<210>  3
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mutant human carboxylesterase

<400>  3

Met Trp Leu Arg Ala Phe Ile Leu Ala Thr Leu Ser Ala Ser Ala Ala 
1               5                   10                  15      


Trp Gly His Pro Ser Ser Pro Pro Val Val Asp Thr Val His Gly Lys 
            20                  25                  30          


Val Leu Gly Lys Phe Val Ser Leu Glu Gly Phe Ala Gln Pro Val Ala 
        35                  40                  45              


Ile Phe Leu Gly Ile Pro Phe Ala Lys Pro Pro Leu Gly Pro Leu Arg 
    50                  55                  60                  


Phe Thr Pro Pro Gln Pro Ala Glu Pro Trp Ser Phe Val Lys Asn Ala 
65                  70                  75                  80  


Thr Ser Tyr Pro Pro Met Cys Thr Gln Asp Pro Lys Ala Gly Gln Leu 
                85                  90                  95      


Leu Ser Glu Leu Phe Thr Asn Arg Lys Glu Asn Ile Pro Leu Lys Leu 
            100                 105                 110         


Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Thr Pro Ala Asp Leu Thr 
        115                 120                 125             


Lys Lys Asn Arg Leu Pro Val Met Val Trp Ile His Gly Gly Gly Leu 
    130                 135                 140                 


Met Val Gly Ala Ala Ser Thr Tyr Asp Gly Leu Ala Leu Ala Ala His 
145                 150                 155                 160 


Glu Asn Val Val Val Val Thr Ile Gln Tyr Arg Leu Gly Ile Trp Gly 
                165                 170                 175     


Phe Phe Ser Thr Gly Asp Glu His Ser Arg Gly Asn Trp Gly His Leu 
            180                 185                 190         


Asp Gln Val Ala Ala Leu Arg Trp Val Gln Asp Asn Ile Ala Ser Phe 
        195                 200                 205             


Gly Gly Asn Pro Gly Ser Val Thr Ile Phe Gly Glu Ser Ala Gly Gly 
    210                 215                 220                 


Glu Ser Val Ser Val Leu Val Leu Ser Pro Leu Ala Lys Asn Leu Phe 
225                 230                 235                 240 


His Arg Ala Ile Ser Glu Ser Gly Val Ala Leu Thr Ser Val Leu Val 
                245                 250                 255     


Lys Lys Gly Asp Val Lys Pro Leu Ala Glu Gln Ile Ala Ile Thr Ala 
            260                 265                 270         


Gly Cys Lys Thr Thr Thr Ser Ala Val Met Val His Cys Leu Arg Gln 
        275                 280                 285             


Lys Thr Glu Glu Glu Leu Leu Glu Thr Thr Leu Lys Met Lys Phe Leu 
    290                 295                 300                 


Ser Leu Asp Leu Gln Gly Asp Pro Arg Glu Ser Gln Pro Leu Leu Gly 
305                 310                 315                 320 


Thr Val Ile Asp Gly Met Leu Leu Leu Lys Thr Pro Glu Glu Leu Gln 
                325                 330                 335     


Ala Glu Arg Asn Phe His Thr Val Pro Tyr Met Val Gly Ile Asn Lys 
            340                 345                 350         


Gln Glu Phe Gly Trp Ile Ile Pro Met Gln Met Leu Gly Tyr Pro Leu 
        355                 360                 365             


Ser Glu Gly Gln Leu Asp Gln Lys Thr Ala Met Ser Leu Leu Trp Lys 
    370                 375                 380                 


Ser Tyr Pro Leu Val Cys Ile Ala Lys Glu Leu Ile Pro Glu Ala Thr 
385                 390                 395                 400 


Glu Lys Tyr Leu Gly Gly Thr Asp Asp Thr Val Lys Lys Lys Asp Leu 
                405                 410                 415     


Phe Leu Asp Leu Ile Ala Asp Val Met Phe Gly Val Pro Ser Val Ile 
            420                 425                 430         


Val Ala Arg Asn His Arg Asp Ala Gly Ala Pro Thr Tyr Met Tyr Glu 
        435                 440                 445             


Tyr Arg Tyr Arg Pro Ser Phe Ser Ser Asp Met Arg Pro Lys Thr Val 
    450                 455                 460                 


Ile Gly Asp His Gly Asp Glu Leu Phe Ser Val Phe Gly Ala Pro Phe 
465                 470                 475                 480 


Leu Lys Glu Gly Ala Ser Glu Glu Glu Ile Arg Leu Ser Lys Met Val 
                485                 490                 495     


Met Lys Phe Trp Ala Asn Phe Ala Arg Asn Gly Asn Pro Asn Gly Glu 
            500                 505                 510         


Gly Leu Pro His Trp Pro Glu Tyr Asn Gln Lys Glu Gly Tyr Leu Gln 
        515                 520                 525             


Ile Gly Ala Asn Thr Gln Ala Ala Gln Lys Leu Lys Asp Lys Glu Val 
    530                 535                 540                 


Ala Phe Trp Thr Asn Leu Phe Ala Lys Lys Ala Val Glu Lys Pro Pro 
545                 550                 555                 560 


Gln Thr Glu His Ile Glu Leu 
                565         


<210>  4
<211>  1763
<212>  DNA
<213>  Homo sapiens

<400>  4
atctaaagcg agaactgtcg cccttcacga tgtggctccg tgcctttatc ctggccactc     60

tctctgcttc cgcggcttgg gggcatccgt cctcgccacc tgtggtggac accgtgcatg    120

gcaaagtgct ggggaagttc gtcagcttag aaggatttgc acagcctgtg gccattttcc    180

tgggaatccc ttttgccaag ccgcctcttg gacccctgag gtttactcca ccgcagcctg    240

cagaaccatg gagctttgtg aagaatgcca cctcgtaccc tcctatgtgc acccaagatc    300

ccaaggcggg gcagttactc tcagagctat ttacaaaccg aaaggagaac attcctctca    360

agctttctga agactgtctt tacctcaata tttacactcc tgctgacttg accaagaaaa    420

acaggctgcc ggtgatggtg tggatccacg gaggggggct gatggtgggt gcggcatcaa    480

cctatgatgg gctggccctt gctgcccatg aaaacgtggt ggtggtgacc attcaatatc    540

gcctgggcat ctggggattc ttcagcacag gggatgaaca cagccggggg aactggggtc    600

acctggacca ggtggctgcc ctgcgctggg tccaggacaa cattgccagc tttggaggga    660

acccaggctc tgtgaccatc tttggagagt cagcgggagg agaaagtgtc tctgttcttg    720

ttttgtctcc attggccaag aacctcttcc accgggccat ttctgagagt ggcgtggccc    780

tcacttctgt tctggtgaag aaaggtgatg tcaagccctt ggctgagcaa attgctatca    840

ctgctgggtg caaaaccacc acctctgctg tcatggttca ctgcctgcga cagaagacgg    900

aagaggagct cttggagacg acattgaaaa tgaaattctt atctctggac ttacagggag    960

accccagaga gagtcaaccc cttctgggca ctgtgattga tgggatgctg ctgctgaaaa   1020

cacctgaaga gcttcaagct gaaaggaatt tccacactgt cccctacatg gtcggaatta   1080

acaagcagga gtttggctgg ttgattccaa tgttgatgag ctatccactc tccgaagggc   1140

aactggacca gaagacagcc atgtcactcc tgtggaagtc ctatcccctt gtttgcattg   1200

ctaaggaact gattccagaa gccactgaga aatacttagg aggaacagac gacactgtca   1260

aaaagaaaga cctgttcctg gacttgatag cagatgtgat gtttggtgtc ccatctgtga   1320

ttgtggcccg gaaccacaga gatgctggag cacccaccta catgtatgag tttcagtacc   1380

gtccaagctt ctcatcagac atgaaaccca agacggtgat aggagaccac ggggatgagc   1440

tcttctccgt ctttggggcc ccatttttaa aagagggtgc ctcagaagag gagatcagac   1500

ttagcaagat ggtgatgaaa ttctgggcca actttgctcg caatggaaac cccaatgggg   1560

aagggctgcc ccactggcca gagtacaacc agaaggaagg gtatctgcag attggtgcca   1620

acacccaggc ggcccagaag ctgaaggaca aagaagtagc tttctggacc aacctctttg   1680

ccaagaaggc agtggagaag ccaccccaga cagaacacat agagctgtga atgaagatcc   1740

agccggcctt gggagcctgg agg                                           1763


<210>  5
<211>  1717
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  5
gaattctgcc atgtggctct gtgcattggc cctggcctct ctcgccgctt gcacggcttg     60

ggggcacccg tctgcaccac ctgtggtaga tactgtgcat ggcaaagtcc tggggaagtt    120

cgtcagctta gaaggatttg cacagcccgt ggccgtcttc ctgggagtcc ccttcgccaa    180

gccccctctt ggatccctga ggtttgcacc accacagcct gcagaatcat ggagccacgt    240

gaagaacacc acctcctacc ctcccatgtg ctcccaggac gcagtatcag ggcatatgct    300

ctcggagctc ttcaccaaca gaaaagagaa catccctctt aagttttctg aagactgcct    360

ttacctgaat atttacaccc ctgctgacct gacaaagaga ggcaggctgc cggtgatggt    420

gtggatccat ggaggtggtc tgatggtggg tggagcatca acctatgatg gcctggctct    480

ttctgcccat gagaacgtgg tggtggtgac cattcagtac cgcctgggca tctggggatt    540

cttcagcaca ggagatgagc acagccgagg gaactggggt cacttggacc aggtggctgc    600

gctgcggtgg gtccaggaca acattgccaa ctttggaggg gacccaggct ctgtgaccat    660

ctttggagag tcagcaggag gtcaaagtgt ctctatcctt ctattatccc ccctgaccaa    720

gaatctcttc catcgagcaa tttccgagag tggcgtggcc ctcctttcca gtctcttcag    780

gaagaacacc aagtccttgg ctgagaaaat tgccatcgaa gctgggtgta aaaccaccac    840

ctcggctgtc atggttcact gcctgcgcca gaagacagag gaagaactca tggaggtgac    900

attgaaaatg aaatttatgg ctctagatct agttggcgac cccaaagaga acaccgcctt    960

cctgaccact gtgattgatg gggtgctgct gccaaaagca cctgcagaga ttctggcaga   1020

gaagaaatac aacatgctgc cctacatggt gggaatcaac cagcaagagt ttggctggat   1080

tatcccaatg caaatgctgg gctatccact ctctgaaggc aaactggacc agaagacagc   1140

tacagaactc ttgtggaagt cctaccccat tgtcaatgtc tctaaggagc tgactccagt   1200

ggccactgag aagtatttag gagggacaga tgaccctgtc aaaaagaaag acttgttcct   1260

ggacatgctt gcagatttgt tatttggtgt cccatctgtg aatgtggctc gtcaccacag   1320

agatgctgga gcccccacct atatgtatga gtatcggtat cgcccaagct tctcatcaga   1380

catgagaccc aagacagtga taggggacca tggagatgag atcttctctg tcttaggagc   1440

cccgttttta aaagagggtg ccacagaaga ggagatcaaa ctgagcaaga tggtgatgaa   1500

atactgggcc aactttgcta ggaatgggaa tcccaatgga gaagggcttc ctcaatggcc   1560

agcatatgac tacaaggaag gttacctgca gattggagcc accacccagg cagcccagaa   1620

actgaaagac aaggaagtgg ctttctggac tgagctctgg gccaaggagg cagcaaggcc   1680

acgtgagaca gagcacattg agctgtgaat tgaattc                            1717


<210>  6
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  6

Gly Trp Ile Ile Pro Met Gln Met Leu Gly Tyr Pro Leu Ser Glu Gly 
1               5                   10                  15      


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Trp Leu Ile Pro Met Leu Met Ser Tyr Pro Leu Ser Glu Gly 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Gly Trp Leu Ile Pro Met Met Leu Ser Tyr Pro Leu Ser Glu Gly 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Gly Trp Ile Ile Pro Met Met Leu Gly Tyr Pro Leu Ser Glu Gly 
1               5                   10                  15  


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

Gly Trp Ile Ile Pro Met Gln Met Leu Gly Tyr Pro Leu Ser Glu Gly 
1               5                   10                  15      


<210>  11
<211>  18
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  11

Tyr Arg Tyr Arg Pro Ser Phe Ser Ser Asp Met Arg Pro Lys Thr Val 
1               5                   10                  15      


Ile Gly 
        


<210>  12
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  12

Phe Gln Tyr Arg Pro Ser Phe Ser Ser Asp Met Lys Pro Lys Thr Val 
1               5                   10                  15      


Ile Gly 
        


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Phe Gln Tyr Arg Pro Ser Phe Ser Ser Asp Met Arg Pro Lys Thr Val 
1               5                   10                  15      


Ile Gly 
        


<210>  14
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Tyr Arg Tyr Arg Pro Ser Phe Ser Ser Asp Met Arg Pro Lys Thr Val 
1               5                   10                  15      


Ile Gly 
        


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Cys Glu Lys Pro Pro Gln Thr Glu His Ile Glu Leu 
1               5                   10          


<210>  16
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthethic mutant human carboxylesterase

<400>  16

Ile Leu Ala Thr Leu Ser Ala Ser Ala Ala Trp Gly His Pro Ser Ser 
1               5                   10                  15      


Pro Pro Val Val Asp Thr Val His Gly Lys Val Leu Gly Lys Phe Val 
            20                  25                  30          


Ser Leu Glu Gly Phe Ala Gln Pro Val Ala Ile Phe Leu Gly Ile Pro 
        35                  40                  45              


Phe Ala Lys Pro Pro Leu Gly Pro Leu Arg Phe Thr Pro Pro Gln Pro 
    50                  55                  60                  


Ala Glu Pro Trp Ser Phe Val Lys Asn Ala Thr Ser Tyr Pro Pro Met 
65                  70                  75                  80  


Cys Thr Gln Asp Pro Lys Ala Gly Gln Leu Leu Ser Glu Leu Phe Thr 
                85                  90                  95      


Asn Arg Lys Glu Asn Ile Pro Leu Lys Leu Ser Glu Asp Cys Leu Tyr 
            100                 105                 110         


Leu Asn Ile Tyr Thr Pro Ala Asp Leu Thr Lys Lys Asn Arg Leu Pro 
        115                 120                 125             


Val Met Val Trp Ile His Gly Gly Gly Leu Met Val Gly Ala Ala Ser 
    130                 135                 140                 


Thr Tyr Asp Gly Leu Ala Leu Ala Ala His Glu Asn Val Val Val Val 
145                 150                 155                 160 


Thr Ile Gln Tyr Arg Leu Gly Ile Trp Gly Phe Phe Ser Thr Gly Asp 
                165                 170                 175     


Glu His Ser Arg Gly Asn Trp Gly His Leu Asp Gln Val Ala Ala Leu 
            180                 185                 190         


Arg Trp Val Gln Asp Asn Ile Ala Ser Phe Gly Gly Asn Pro Gly Ser 
        195                 200                 205             


Val Thr Ile Phe Gly Glu Ser Ala Gly Gly Glu Ser Val Ser Val Leu 
    210                 215                 220                 


Val Leu Ser Pro Leu Ala Lys Asn Leu Phe His Arg Ala Ile Ser Glu 
225                 230                 235                 240 


Ser Gly Val Ala Leu Thr Ser Val Leu Val Lys Lys Gly Asp Val Lys 
                245                 250                 255     


Pro Leu Ala Glu Gln Ile Ala Ile Thr Ala Gly Cys Lys Thr Thr Thr 
            260                 265                 270         


Ser Ala Val Met Val His Cys Leu Arg Gln Lys Thr Glu Glu Glu Leu 
        275                 280                 285             


Leu Glu Thr Thr Leu Lys Met Lys Phe Leu Ser Leu Asp Leu Gln Gly 
    290                 295                 300                 


Asp Pro Arg Glu Ser Gln Pro Leu Leu Gly Thr Val Ile Asp Gly Met 
305                 310                 315                 320 


Leu Leu Leu Lys Thr Pro Glu Glu Leu Gln Ala Glu Arg Asn Phe His 
                325                 330                 335     


Thr Val Pro Tyr Met Val Gly Ile Asn Lys Gln Glu Phe Gly Trp Ile 
            340                 345                 350         


Ile Pro Met Gln Met Leu Gly Tyr Pro Leu Ser Glu Gly Gln Leu Asp 
        355                 360                 365             


Gln Lys Thr Ala Met Ser Leu Leu Trp Lys Ser Tyr Pro Leu Val Cys 
    370                 375                 380                 


Ile Ala Lys Glu Leu Ile Pro Glu Ala Thr Glu Lys Tyr Leu Gly Gly 
385                 390                 395                 400 


Thr Asp Asp Thr Val Lys Lys Lys Asp Leu Phe Leu Asp Leu Ile Ala 
                405                 410                 415     


Asp Val Met Phe Gly Val Pro Ser Val Ile Val Ala Arg Asn His Arg 
            420                 425                 430         


Asp Ala Gly Ala Pro Thr Tyr Met Tyr Glu Tyr Arg Tyr Arg Pro Ser 
        435                 440                 445             


Phe Ser Ser Asp Met Arg Pro Lys Thr Val Ile Gly Asp His Gly Asp 
    450                 455                 460                 


Glu Leu Phe Ser Val Phe Gly Ala Pro Phe Leu Lys Glu Gly Ala Ser 
465                 470                 475                 480 


Glu Glu Glu Ile Arg Leu Ser Lys Met Val Met Lys Phe Trp Ala Asn 
                485                 490                 495     


Phe Ala Arg Asn Gly Asn Pro Asn Gly Glu Gly Leu Pro His Trp Pro 
            500                 505                 510         


Glu Tyr Asn Gln Lys Glu Gly Tyr Leu Gln Ile Gly Ala Asn Thr Gln 
        515                 520                 525             


Ala Ala Gln Lys Leu Lys Asp Lys Glu Val Ala Phe Trp Thr Asn Leu 
    530                 535                 540                 


Phe Ala Lys Lys Ala Val Glu Lys Pro Pro Gln Thr Glu His Ile Glu 
545                 550                 555                 560 


Leu 
    


