<110>    Korea Ocean Research & Development Institute

<120>    Mutant DNA Polymerases and Their Genes From Themococcus

<160>    36

<170>    KopatentIn 1.71

<210>    1
<211>    11
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    1
Lys Met Leu Ala Phe Ala Ile Glu Thr Leu Tyr
  1               5                  10    


<210>    2
<211>    11
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    2
Val Leu Ile Thr Tyr Asp Gly Asp Asn Phe Asp
  1               5                  10    


<210>    3
<211>    11
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    3
Leu Ile Thr Tyr Asn Asp Asp Asn Phe Asp Phe
  1               5                  10    


<210>    4
<211>    11
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    4
Ile Thr Tyr Asn Gly Ala Asn Phe Asp Phe Ala
  1               5                  10    


<210>    5
<211>    11
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    5
Thr Tyr Asn Gly Asp Ala Phe Asp Phe Ala Tyr
  1               5                  10    


<210>    6
<211>    11
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    6
Thr Tyr Asn Gly Asp Asp Phe Asp Phe Ala Tyr
  1               5                  10    


<210>    7
<211>    11
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    7
Thr Tyr Asn Gly Asp Glu Phe Asp Phe Ala Tyr
  1               5                  10    


<210>    8
<211>    11
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    8
Thr Tyr Asn Gly Asp Phe Phe Asp Phe Ala Tyr
  1               5                  10    


<210>    9
<211>    11
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    9
Thr Tyr Asn Gly Asp Arg Phe Asp Phe Ala Tyr
  1               5                  10    


<210>    10
<211>    11
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    10
Tyr Asn Gly Asp Asn Asp Asp Phe Ala Tyr Leu
  1               5                  10    


<210>    11
<211>    11
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    11
Asn Gly Asp Asn Phe Ala Phe Ala Tyr Leu Lys
  1               5                  10    


<210>    12
<211>    11
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    12
Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala
  1               5                  10    


<210>    13
<211>    773
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    13
Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile
  1               5                  10                  15 

Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Glu Tyr Asp Arg
             20                  25                  30 

Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
         35                  40                  45 

Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val Lys
     50                  55                  60 

Val Lys Arg Ala Glu Lys Val Asn Lys Lys Phe Leu Gly Arg Pro Val
 65                  70                  75                  80 

Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile
                 85                  90                  95 

Arg Asp Lys Ile Arg Ala His Pro Gly Val Ile Asp Ile Tyr Glu Tyr
            100                 105                 110 

Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro
        115                 120                 125 

Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Ala Ile Glu Thr
    130                 135                 140 

Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile
145                 150                 155                 160 

Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
                165                 170                 175 

Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys
            180                 185                 190 

Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
        195                 200                 205 

Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu
    210                 215                 220 

Lys Leu Gly Ile Ser Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys
225                 230                 235                 240 

Ile His Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile
                245                 250                 255 

His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr
            260                 265                 270 

Tyr Thr Leu Glu Val Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu
        275                 280                 285 

Lys Val Tyr Ala Glu Glu Ile Thr Leu Ala Trp Glu Ser Gly Glu Gly
    290                 295                 300 

Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr
305                 310                 315                 320 

Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu
                325                 330                 335 

Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu
            340                 345                 350 

Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala
        355                 360                 365 

Pro Asn Lys Pro Asp Glu Gly Glu Leu Ala Arg Arg Arg Asn Ser Tyr
    370                 375                 380 

Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile
385                 390                 395                 400 

Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His
                405                 410                 415 

Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
            420                 425                 430 

Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe
        435                 440                 445 

Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile Lys
    450                 455                 460 

Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Leu Leu Asp
465                 470                 475                 480 

Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr
                485                 490                 495 

Tyr Gly Tyr Pro Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser
            500                 505                 510 

Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Thr Ile Arg Glu Ile
        515                 520                 525 

Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe
    530                 535                 540 

Tyr Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545                 550                 555                 560 

Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
                565                 570                 575 

Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys
            580                 585                 590 

Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu
        595                 600                 605 

Glu Ile Val Arg Arg Asp Trp Ser Asp Ile Ala Lys Glu Thr Gln Ala
    610                 615                 620 

Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Lys Ala Val
625                 630                 635                 640 

Lys Ile Val Lys Glu Ile Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro
                645                 650                 655 

Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp
            660                 665                 670 

Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala
        675                 680                 685 

Arg Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu
    690                 695                 700 

Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705                 710                 715                 720 

Asp Pro Thr Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln
                725                 730                 735 

Val Leu Pro Ala Val Met Arg Ile Leu Glu Ala Phe Gly Tyr Lys Lys
            740                 745                 750 

Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp
        755                 760                 765 

Leu Lys Pro Lys Lys
    770            


<210>    14
<211>    773
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    14
Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile
  1               5                  10                  15 

Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Glu Tyr Asp Arg
             20                  25                  30 

Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
         35                  40                  45 

Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val Lys
     50                  55                  60 

Val Lys Arg Ala Glu Lys Val Asn Lys Lys Phe Leu Gly Arg Pro Val
 65                  70                  75                  80 

Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile
                 85                  90                  95 

Arg Asp Lys Ile Arg Ala His Pro Gly Val Ile Asp Ile Tyr Glu Tyr
            100                 105                 110 

Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro
        115                 120                 125 

Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr
    130                 135                 140 

Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile
145                 150                 155                 160 

Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
                165                 170                 175 

Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys
            180                 185                 190 

Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
        195                 200                 205 

Tyr Asp Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu
    210                 215                 220 

Lys Leu Gly Ile Ser Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys
225                 230                 235                 240 

Ile His Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile
                245                 250                 255 

His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr
            260                 265                 270 

Tyr Thr Leu Glu Val Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu
        275                 280                 285 

Lys Val Tyr Ala Glu Glu Ile Thr Leu Ala Trp Glu Ser Gly Glu Gly
    290                 295                 300 

Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr
305                 310                 315                 320 

Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu
                325                 330                 335 

Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu
            340                 345                 350 

Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala
        355                 360                 365 

Pro Asn Lys Pro Asp Glu Gly Glu Leu Ala Arg Arg Arg Asn Ser Tyr
    370                 375                 380 

Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile
385                 390                 395                 400 

Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His
                405                 410                 415 

Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
            420                 425                 430 

Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe
        435                 440                 445 

Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile Lys
    450                 455                 460 

Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Leu Leu Asp
465                 470                 475                 480 

Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr
                485                 490                 495 

Tyr Gly Tyr Pro Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser
            500                 505                 510 

Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Thr Ile Arg Glu Ile
        515                 520                 525 

Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe
    530                 535                 540 

Tyr Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545                 550                 555                 560 

Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
                565                 570                 575 

Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys
            580                 585                 590 

Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu
        595                 600                 605 

Glu Ile Val Arg Arg Asp Trp Ser Asp Ile Ala Lys Glu Thr Gln Ala
    610                 615                 620 

Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Lys Ala Val
625                 630                 635                 640 

Lys Ile Val Lys Glu Ile Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro
                645                 650                 655 

Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp
            660                 665                 670 

Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala
        675                 680                 685 

Arg Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu
    690                 695                 700 

Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705                 710                 715                 720 

Asp Pro Thr Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln
                725                 730                 735 

Val Leu Pro Ala Val Met Arg Ile Leu Glu Ala Phe Gly Tyr Lys Lys
            740                 745                 750 

Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp
        755                 760                 765 

Leu Lys Pro Lys Lys
    770            


<210>    15
<211>    773
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    15
Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile
  1               5                  10                  15 

Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Glu Tyr Asp Arg
             20                  25                  30 

Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
         35                  40                  45 

Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val Lys
     50                  55                  60 

Val Lys Arg Ala Glu Lys Val Asn Lys Lys Phe Leu Gly Arg Pro Val
 65                  70                  75                  80 

Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile
                 85                  90                  95 

Arg Asp Lys Ile Arg Ala His Pro Gly Val Ile Asp Ile Tyr Glu Tyr
            100                 105                 110 

Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro
        115                 120                 125 

Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr
    130                 135                 140 

Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile
145                 150                 155                 160 

Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
                165                 170                 175 

Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys
            180                 185                 190 

Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
        195                 200                 205 

Tyr Asn Asp Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu
    210                 215                 220 

Lys Leu Gly Ile Ser Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys
225                 230                 235                 240 

Ile His Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile
                245                 250                 255 

His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr
            260                 265                 270 

Tyr Thr Leu Glu Val Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu
        275                 280                 285 

Lys Val Tyr Ala Glu Glu Ile Thr Leu Ala Trp Glu Ser Gly Glu Gly
    290                 295                 300 

Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr
305                 310                 315                 320 

Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu
                325                 330                 335 

Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu
            340                 345                 350 

Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala
        355                 360                 365 

Pro Asn Lys Pro Asp Glu Gly Glu Leu Ala Arg Arg Arg Asn Ser Tyr
    370                 375                 380 

Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile
385                 390                 395                 400 

Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His
                405                 410                 415 

Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
            420                 425                 430 

Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe
        435                 440                 445 

Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile Lys
    450                 455                 460 

Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Leu Leu Asp
465                 470                 475                 480 

Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr
                485                 490                 495 

Tyr Gly Tyr Pro Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser
            500                 505                 510 

Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Thr Ile Arg Glu Ile
        515                 520                 525 

Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe
    530                 535                 540 

Tyr Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545                 550                 555                 560 

Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
                565                 570                 575 

Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys
            580                 585                 590 

Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu
        595                 600                 605 

Glu Ile Val Arg Arg Asp Trp Ser Asp Ile Ala Lys Glu Thr Gln Ala
    610                 615                 620 

Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Lys Ala Val
625                 630                 635                 640 

Lys Ile Val Lys Glu Ile Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro
                645                 650                 655 

Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp
            660                 665                 670 

Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala
        675                 680                 685 

Arg Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu
    690                 695                 700 

Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705                 710                 715                 720 

Asp Pro Thr Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln
                725                 730                 735 

Val Leu Pro Ala Val Met Arg Ile Leu Glu Ala Phe Gly Tyr Lys Lys
            740                 745                 750 

Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp
        755                 760                 765 

Leu Lys Pro Lys Lys
    770            


<210>    16
<211>    773
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    16
Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile
  1               5                  10                  15 

Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Glu Tyr Asp Arg
             20                  25                  30 

Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
         35                  40                  45 

Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val Lys
     50                  55                  60 

Val Lys Arg Ala Glu Lys Val Asn Lys Lys Phe Leu Gly Arg Pro Val
 65                  70                  75                  80 

Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile
                 85                  90                  95 

Arg Asp Lys Ile Arg Ala His Pro Gly Val Ile Asp Ile Tyr Glu Tyr
            100                 105                 110 

Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro
        115                 120                 125 

Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr
    130                 135                 140 

Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile
145                 150                 155                 160 

Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
                165                 170                 175 

Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys
            180                 185                 190 

Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
        195                 200                 205 

Tyr Asn Gly Ala Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu
    210                 215                 220 

Lys Leu Gly Ile Ser Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys
225                 230                 235                 240 

Ile His Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile
                245                 250                 255 

His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr
            260                 265                 270 

Tyr Thr Leu Glu Val Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu
        275                 280                 285 

Lys Val Tyr Ala Glu Glu Ile Thr Leu Ala Trp Glu Ser Gly Glu Gly
    290                 295                 300 

Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr
305                 310                 315                 320 

Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu
                325                 330                 335 

Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu
            340                 345                 350 

Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala
        355                 360                 365 

Pro Asn Lys Pro Asp Glu Gly Glu Leu Ala Arg Arg Arg Asn Ser Tyr
    370                 375                 380 

Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile
385                 390                 395                 400 

Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His
                405                 410                 415 

Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
            420                 425                 430 

Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe
        435                 440                 445 

Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile Lys
    450                 455                 460 

Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Leu Leu Asp
465                 470                 475                 480 

Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr
                485                 490                 495 

Tyr Gly Tyr Pro Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser
            500                 505                 510 

Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Thr Ile Arg Glu Ile
        515                 520                 525 

Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe
    530                 535                 540 

Tyr Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545                 550                 555                 560 

Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
                565                 570                 575 

Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys
            580                 585                 590 

Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu
        595                 600                 605 

Glu Ile Val Arg Arg Asp Trp Ser Asp Ile Ala Lys Glu Thr Gln Ala
    610                 615                 620 

Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Lys Ala Val
625                 630                 635                 640 

Lys Ile Val Lys Glu Ile Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro
                645                 650                 655 

Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp
            660                 665                 670 

Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala
        675                 680                 685 

Arg Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu
    690                 695                 700 

Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705                 710                 715                 720 

Asp Pro Thr Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln
                725                 730                 735 

Val Leu Pro Ala Val Met Arg Ile Leu Glu Ala Phe Gly Tyr Lys Lys
            740                 745                 750 

Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp
        755                 760                 765 

Leu Lys Pro Lys Lys
    770            


<210>    17
<211>    773
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    17
Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile
  1               5                  10                  15 

Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Glu Tyr Asp Arg
             20                  25                  30 

Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
         35                  40                  45 

Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val Lys
     50                  55                  60 

Val Lys Arg Ala Glu Lys Val Asn Lys Lys Phe Leu Gly Arg Pro Val
 65                  70                  75                  80 

Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile
                 85                  90                  95 

Arg Asp Lys Ile Arg Ala His Pro Gly Val Ile Asp Ile Tyr Glu Tyr
            100                 105                 110 

Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro
        115                 120                 125 

Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr
    130                 135                 140 

Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile
145                 150                 155                 160 

Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
                165                 170                 175 

Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys
            180                 185                 190 

Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
        195                 200                 205 

Tyr Asn Gly Asp Ala Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu
    210                 215                 220 

Lys Leu Gly Ile Ser Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys
225                 230                 235                 240 

Ile His Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile
                245                 250                 255 

His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr
            260                 265                 270 

Tyr Thr Leu Glu Val Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu
        275                 280                 285 

Lys Val Tyr Ala Glu Glu Ile Thr Leu Ala Trp Glu Ser Gly Glu Gly
    290                 295                 300 

Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr
305                 310                 315                 320 

Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu
                325                 330                 335 

Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu
            340                 345                 350 

Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala
        355                 360                 365 

Pro Asn Lys Pro Asp Glu Gly Glu Leu Ala Arg Arg Arg Asn Ser Tyr
    370                 375                 380 

Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile
385                 390                 395                 400 

Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His
                405                 410                 415 

Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
            420                 425                 430 

Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe
        435                 440                 445 

Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile Lys
    450                 455                 460 

Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Leu Leu Asp
465                 470                 475                 480 

Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr
                485                 490                 495 

Tyr Gly Tyr Pro Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser
            500                 505                 510 

Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Thr Ile Arg Glu Ile
        515                 520                 525 

Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe
    530                 535                 540 

Tyr Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545                 550                 555                 560 

Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
                565                 570                 575 

Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys
            580                 585                 590 

Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu
        595                 600                 605 

Glu Ile Val Arg Arg Asp Trp Ser Asp Ile Ala Lys Glu Thr Gln Ala
    610                 615                 620 

Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Lys Ala Val
625                 630                 635                 640 

Lys Ile Val Lys Glu Ile Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro
                645                 650                 655 

Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp
            660                 665                 670 

Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala
        675                 680                 685 

Arg Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu
    690                 695                 700 

Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705                 710                 715                 720 

Asp Pro Thr Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln
                725                 730                 735 

Val Leu Pro Ala Val Met Arg Ile Leu Glu Ala Phe Gly Tyr Lys Lys
            740                 745                 750 

Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp
        755                 760                 765 

Leu Lys Pro Lys Lys
    770            


<210>    18
<211>    773
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    18
Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile
  1               5                  10                  15 

Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Glu Tyr Asp Arg
             20                  25                  30 

Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
         35                  40                  45 

Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val Lys
     50                  55                  60 

Val Lys Arg Ala Glu Lys Val Asn Lys Lys Phe Leu Gly Arg Pro Val
 65                  70                  75                  80 

Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile
                 85                  90                  95 

Arg Asp Lys Ile Arg Ala His Pro Gly Val Ile Asp Ile Tyr Glu Tyr
            100                 105                 110 

Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro
        115                 120                 125 

Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr
    130                 135                 140 

Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile
145                 150                 155                 160 

Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
                165                 170                 175 

Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys
            180                 185                 190 

Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
        195                 200                 205 

Tyr Asn Gly Asp Asp Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu
    210                 215                 220 

Lys Leu Gly Ile Ser Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys
225                 230                 235                 240 

Ile His Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile
                245                 250                 255 

His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr
            260                 265                 270 

Tyr Thr Leu Glu Val Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu
        275                 280                 285 

Lys Val Tyr Ala Glu Glu Ile Thr Leu Ala Trp Glu Ser Gly Glu Gly
    290                 295                 300 

Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr
305                 310                 315                 320 

Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu
                325                 330                 335 

Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu
            340                 345                 350 

Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala
        355                 360                 365 

Pro Asn Lys Pro Asp Glu Gly Glu Leu Ala Arg Arg Arg Asn Ser Tyr
    370                 375                 380 

Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile
385                 390                 395                 400 

Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His
                405                 410                 415 

Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
            420                 425                 430 

Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe
        435                 440                 445 

Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile Lys
    450                 455                 460 

Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Leu Leu Asp
465                 470                 475                 480 

Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr
                485                 490                 495 

Tyr Gly Tyr Pro Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser
            500                 505                 510 

Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Thr Ile Arg Glu Ile
        515                 520                 525 

Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe
    530                 535                 540 

Tyr Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545                 550                 555                 560 

Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
                565                 570                 575 

Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys
            580                 585                 590 

Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu
        595                 600                 605 

Glu Ile Val Arg Arg Asp Trp Ser Asp Ile Ala Lys Glu Thr Gln Ala
    610                 615                 620 

Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Lys Ala Val
625                 630                 635                 640 

Lys Ile Val Lys Glu Ile Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro
                645                 650                 655 

Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp
            660                 665                 670 

Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala
        675                 680                 685 

Arg Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu
    690                 695                 700 

Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705                 710                 715                 720 

Asp Pro Thr Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln
                725                 730                 735 

Val Leu Pro Ala Val Met Arg Ile Leu Glu Ala Phe Gly Tyr Lys Lys
            740                 745                 750 

Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp
        755                 760                 765 

Leu Lys Pro Lys Lys
    770            


<210>    19
<211>    773
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    19
Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile
  1               5                  10                  15 

Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Glu Tyr Asp Arg
             20                  25                  30 

Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
         35                  40                  45 

Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val Lys
     50                  55                  60 

Val Lys Arg Ala Glu Lys Val Asn Lys Lys Phe Leu Gly Arg Pro Val
 65                  70                  75                  80 

Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile
                 85                  90                  95 

Arg Asp Lys Ile Arg Ala His Pro Gly Val Ile Asp Ile Tyr Glu Tyr
            100                 105                 110 

Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro
        115                 120                 125 

Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr
    130                 135                 140 

Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile
145                 150                 155                 160 

Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
                165                 170                 175 

Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys
            180                 185                 190 

Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
        195                 200                 205 

Tyr Asn Gly Asp Glu Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu
    210                 215                 220 

Lys Leu Gly Ile Ser Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys
225                 230                 235                 240 

Ile His Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile
                245                 250                 255 

His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr
            260                 265                 270 

Tyr Thr Leu Glu Val Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu
        275                 280                 285 

Lys Val Tyr Ala Glu Glu Ile Thr Leu Ala Trp Glu Ser Gly Glu Gly
    290                 295                 300 

Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr
305                 310                 315                 320 

Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu
                325                 330                 335 

Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu
            340                 345                 350 

Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala
        355                 360                 365 

Pro Asn Lys Pro Asp Glu Gly Glu Leu Ala Arg Arg Arg Asn Ser Tyr
    370                 375                 380 

Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile
385                 390                 395                 400 

Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His
                405                 410                 415 

Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
            420                 425                 430 

Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe
        435                 440                 445 

Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile Lys
    450                 455                 460 

Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Leu Leu Asp
465                 470                 475                 480 

Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr
                485                 490                 495 

Tyr Gly Tyr Pro Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser
            500                 505                 510 

Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Thr Ile Arg Glu Ile
        515                 520                 525 

Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe
    530                 535                 540 

Tyr Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545                 550                 555                 560 

Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
                565                 570                 575 

Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys
            580                 585                 590 

Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu
        595                 600                 605 

Glu Ile Val Arg Arg Asp Trp Ser Asp Ile Ala Lys Glu Thr Gln Ala
    610                 615                 620 

Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Lys Ala Val
625                 630                 635                 640 

Lys Ile Val Lys Glu Ile Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro
                645                 650                 655 

Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp
            660                 665                 670 

Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala
        675                 680                 685 

Arg Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu
    690                 695                 700 

Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705                 710                 715                 720 

Asp Pro Thr Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln
                725                 730                 735 

Val Leu Pro Ala Val Met Arg Ile Leu Glu Ala Phe Gly Tyr Lys Lys
            740                 745                 750 

Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp
        755                 760                 765 

Leu Lys Pro Lys Lys
    770            


<210>    20
<211>    773
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    20
Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile
  1               5                  10                  15 

Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Glu Tyr Asp Arg
             20                  25                  30 

Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
         35                  40                  45 

Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val Lys
     50                  55                  60 

Val Lys Arg Ala Glu Lys Val Asn Lys Lys Phe Leu Gly Arg Pro Val
 65                  70                  75                  80 

Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile
                 85                  90                  95 

Arg Asp Lys Ile Arg Ala His Pro Gly Val Ile Asp Ile Tyr Glu Tyr
            100                 105                 110 

Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro
        115                 120                 125 

Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr
    130                 135                 140 

Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile
145                 150                 155                 160 

Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
                165                 170                 175 

Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys
            180                 185                 190 

Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
        195                 200                 205 

Tyr Asn Gly Asp Phe Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu
    210                 215                 220 

Lys Leu Gly Ile Ser Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys
225                 230                 235                 240 

Ile His Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile
                245                 250                 255 

His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr
            260                 265                 270 

Tyr Thr Leu Glu Val Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu
        275                 280                 285 

Lys Val Tyr Ala Glu Glu Ile Thr Leu Ala Trp Glu Ser Gly Glu Gly
    290                 295                 300 

Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr
305                 310                 315                 320 

Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu
                325                 330                 335 

Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu
            340                 345                 350 

Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala
        355                 360                 365 

Pro Asn Lys Pro Asp Glu Gly Glu Leu Ala Arg Arg Arg Asn Ser Tyr
    370                 375                 380 

Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile
385                 390                 395                 400 

Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His
                405                 410                 415 

Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
            420                 425                 430 

Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe
        435                 440                 445 

Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile Lys
    450                 455                 460 

Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Leu Leu Asp
465                 470                 475                 480 

Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr
                485                 490                 495 

Tyr Gly Tyr Pro Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser
            500                 505                 510 

Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Thr Ile Arg Glu Ile
        515                 520                 525 

Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe
    530                 535                 540 

Tyr Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545                 550                 555                 560 

Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
                565                 570                 575 

Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys
            580                 585                 590 

Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu
        595                 600                 605 

Glu Ile Val Arg Arg Asp Trp Ser Asp Ile Ala Lys Glu Thr Gln Ala
    610                 615                 620 

Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Lys Ala Val
625                 630                 635                 640 

Lys Ile Val Lys Glu Ile Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro
                645                 650                 655 

Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp
            660                 665                 670 

Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala
        675                 680                 685 

Arg Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu
    690                 695                 700 

Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705                 710                 715                 720 

Asp Pro Thr Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln
                725                 730                 735 

Val Leu Pro Ala Val Met Arg Ile Leu Glu Ala Phe Gly Tyr Lys Lys
            740                 745                 750 

Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp
        755                 760                 765 

Leu Lys Pro Lys Lys
    770            


<210>    21
<211>    773
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    21
Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile
  1               5                  10                  15 

Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Glu Tyr Asp Arg
             20                  25                  30 

Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
         35                  40                  45 

Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val Lys
     50                  55                  60 

Val Lys Arg Ala Glu Lys Val Asn Lys Lys Phe Leu Gly Arg Pro Val
 65                  70                  75                  80 

Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile
                 85                  90                  95 

Arg Asp Lys Ile Arg Ala His Pro Gly Val Ile Asp Ile Tyr Glu Tyr
            100                 105                 110 

Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro
        115                 120                 125 

Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr
    130                 135                 140 

Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile
145                 150                 155                 160 

Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
                165                 170                 175 

Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys
            180                 185                 190 

Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
        195                 200                 205 

Tyr Asn Gly Asp Arg Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu
    210                 215                 220 

Lys Leu Gly Ile Ser Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys
225                 230                 235                 240 

Ile His Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile
                245                 250                 255 

His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr
            260                 265                 270 

Tyr Thr Leu Glu Val Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu
        275                 280                 285 

Lys Val Tyr Ala Glu Glu Ile Thr Leu Ala Trp Glu Ser Gly Glu Gly
    290                 295                 300 

Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr
305                 310                 315                 320 

Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu
                325                 330                 335 

Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu
            340                 345                 350 

Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala
        355                 360                 365 

Pro Asn Lys Pro Asp Glu Gly Glu Leu Ala Arg Arg Arg Asn Ser Tyr
    370                 375                 380 

Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile
385                 390                 395                 400 

Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His
                405                 410                 415 

Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
            420                 425                 430 

Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe
        435                 440                 445 

Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile Lys
    450                 455                 460 

Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Leu Leu Asp
465                 470                 475                 480 

Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr
                485                 490                 495 

Tyr Gly Tyr Pro Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser
            500                 505                 510 

Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Thr Ile Arg Glu Ile
        515                 520                 525 

Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe
    530                 535                 540 

Tyr Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545                 550                 555                 560 

Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
                565                 570                 575 

Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys
            580                 585                 590 

Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu
        595                 600                 605 

Glu Ile Val Arg Arg Asp Trp Ser Asp Ile Ala Lys Glu Thr Gln Ala
    610                 615                 620 

Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Lys Ala Val
625                 630                 635                 640 

Lys Ile Val Lys Glu Ile Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro
                645                 650                 655 

Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp
            660                 665                 670 

Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala
        675                 680                 685 

Arg Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu
    690                 695                 700 

Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705                 710                 715                 720 

Asp Pro Thr Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln
                725                 730                 735 

Val Leu Pro Ala Val Met Arg Ile Leu Glu Ala Phe Gly Tyr Lys Lys
            740                 745                 750 

Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp
        755                 760                 765 

Leu Lys Pro Lys Lys
    770            


<210>    22
<211>    773
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    22
Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile
  1               5                  10                  15 

Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Glu Tyr Asp Arg
             20                  25                  30 

Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
         35                  40                  45 

Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val Lys
     50                  55                  60 

Val Lys Arg Ala Glu Lys Val Asn Lys Lys Phe Leu Gly Arg Pro Val
 65                  70                  75                  80 

Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile
                 85                  90                  95 

Arg Asp Lys Ile Arg Ala His Pro Gly Val Ile Asp Ile Tyr Glu Tyr
            100                 105                 110 

Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro
        115                 120                 125 

Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr
    130                 135                 140 

Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile
145                 150                 155                 160 

Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
                165                 170                 175 

Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys
            180                 185                 190 

Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
        195                 200                 205 

Tyr Asn Gly Asp Asn Asp Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu
    210                 215                 220 

Lys Leu Gly Ile Ser Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys
225                 230                 235                 240 

Ile His Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile
                245                 250                 255 

His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr
            260                 265                 270 

Tyr Thr Leu Glu Val Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu
        275                 280                 285 

Lys Val Tyr Ala Glu Glu Ile Thr Leu Ala Trp Glu Ser Gly Glu Gly
    290                 295                 300 

Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr
305                 310                 315                 320 

Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu
                325                 330                 335 

Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu
            340                 345                 350 

Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala
        355                 360                 365 

Pro Asn Lys Pro Asp Glu Gly Glu Leu Ala Arg Arg Arg Asn Ser Tyr
    370                 375                 380 

Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile
385                 390                 395                 400 

Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His
                405                 410                 415 

Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
            420                 425                 430 

Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe
        435                 440                 445 

Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile Lys
    450                 455                 460 

Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Leu Leu Asp
465                 470                 475                 480 

Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr
                485                 490                 495 

Tyr Gly Tyr Pro Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser
            500                 505                 510 

Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Thr Ile Arg Glu Ile
        515                 520                 525 

Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe
    530                 535                 540 

Tyr Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545                 550                 555                 560 

Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
                565                 570                 575 

Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys
            580                 585                 590 

Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu
        595                 600                 605 

Glu Ile Val Arg Arg Asp Trp Ser Asp Ile Ala Lys Glu Thr Gln Ala
    610                 615                 620 

Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Lys Ala Val
625                 630                 635                 640 

Lys Ile Val Lys Glu Ile Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro
                645                 650                 655 

Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp
            660                 665                 670 

Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala
        675                 680                 685 

Arg Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu
    690                 695                 700 

Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705                 710                 715                 720 

Asp Pro Thr Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln
                725                 730                 735 

Val Leu Pro Ala Val Met Arg Ile Leu Glu Ala Phe Gly Tyr Lys Lys
            740                 745                 750 

Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp
        755                 760                 765 

Leu Lys Pro Lys Lys
    770            


<210>    23
<211>    773
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    23
Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile
  1               5                  10                  15 

Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Glu Tyr Asp Arg
             20                  25                  30 

Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
         35                  40                  45 

Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val Lys
     50                  55                  60 

Val Lys Arg Ala Glu Lys Val Asn Lys Lys Phe Leu Gly Arg Pro Val
 65                  70                  75                  80 

Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile
                 85                  90                  95 

Arg Asp Lys Ile Arg Ala His Pro Gly Val Ile Asp Ile Tyr Glu Tyr
            100                 105                 110 

Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro
        115                 120                 125 

Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr
    130                 135                 140 

Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile
145                 150                 155                 160 

Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
                165                 170                 175 

Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys
            180                 185                 190 

Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
        195                 200                 205 

Tyr Asn Gly Asp Asn Phe Ala Phe Ala Tyr Leu Lys Lys Arg Cys Glu
    210                 215                 220 

Lys Leu Gly Ile Ser Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys
225                 230                 235                 240 

Ile His Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile
                245                 250                 255 

His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr
            260                 265                 270 

Tyr Thr Leu Glu Val Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu
        275                 280                 285 

Lys Val Tyr Ala Glu Glu Ile Thr Leu Ala Trp Glu Ser Gly Glu Gly
    290                 295                 300 

Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr
305                 310                 315                 320 

Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu
                325                 330                 335 

Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu
            340                 345                 350 

Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala
        355                 360                 365 

Pro Asn Lys Pro Asp Glu Gly Glu Leu Ala Arg Arg Arg Asn Ser Tyr
    370                 375                 380 

Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile
385                 390                 395                 400 

Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His
                405                 410                 415 

Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
            420                 425                 430 

Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe
        435                 440                 445 

Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile Lys
    450                 455                 460 

Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Leu Leu Asp
465                 470                 475                 480 

Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr
                485                 490                 495 

Tyr Gly Tyr Pro Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser
            500                 505                 510 

Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Thr Ile Arg Glu Ile
        515                 520                 525 

Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe
    530                 535                 540 

Tyr Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545                 550                 555                 560 

Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
                565                 570                 575 

Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys
            580                 585                 590 

Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu
        595                 600                 605 

Glu Ile Val Arg Arg Asp Trp Ser Asp Ile Ala Lys Glu Thr Gln Ala
    610                 615                 620 

Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Lys Ala Val
625                 630                 635                 640 

Lys Ile Val Lys Glu Ile Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro
                645                 650                 655 

Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp
            660                 665                 670 

Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala
        675                 680                 685 

Arg Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu
    690                 695                 700 

Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705                 710                 715                 720 

Asp Pro Thr Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln
                725                 730                 735 

Val Leu Pro Ala Val Met Arg Ile Leu Glu Ala Phe Gly Tyr Lys Lys
            740                 745                 750 

Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp
        755                 760                 765 

Leu Lys Pro Lys Lys
    770            


<210>    24
<211>    773
<212>    PRT
<213>    Thermococcus sp. NA1

<400>    24
Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile
  1               5                  10                  15 

Arg Ile Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Glu Tyr Asp Arg
             20                  25                  30 

Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
         35                  40                  45 

Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val Lys
     50                  55                  60 

Val Lys Arg Ala Glu Lys Val Asn Lys Lys Phe Leu Gly Arg Pro Val
 65                  70                  75                  80 

Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile
                 85                  90                  95 

Arg Asp Lys Ile Arg Ala His Pro Gly Val Ile Asp Ile Tyr Glu Tyr
            100                 105                 110 

Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro
        115                 120                 125 

Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr
    130                 135                 140 

Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile
145                 150                 155                 160 

Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
                165                 170                 175 

Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys
            180                 185                 190 

Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
        195                 200                 205 

Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu
    210                 215                 220 

Lys Leu Gly Ile Ser Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys
225                 230                 235                 240 

Ile His Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile
                245                 250                 255 

His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr
            260                 265                 270 

Tyr Thr Leu Glu Val Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu
        275                 280                 285 

Lys Val Tyr Ala Glu Glu Ile Thr Leu Ala Trp Glu Ser Gly Glu Gly
    290                 295                 300 

Leu Glu Arg Val Ala Arg Phe Ser Met Glu Asp Ala Lys Ala Thr Tyr
305                 310                 315                 320 

Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu
                325                 330                 335 

Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu
            340                 345                 350 

Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala
        355                 360                 365 

Pro Asn Lys Pro Asp Glu Gly Glu Leu Ala Arg Arg Arg Asn Ser Tyr
    370                 375                 380 

Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile
385                 390                 395                 400 

Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His
                405                 410                 415 

Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
            420                 425                 430 

Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe
        435                 440                 445 

Ile Pro Ser Leu Leu Gly Asn Leu Leu Glu Glu Arg Gln Lys Ile Lys
    450                 455                 460 

Arg Lys Met Lys Ala Thr Ile Asp Pro Leu Glu Lys Lys Leu Leu Asp
465                 470                 475                 480 

Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr
                485                 490                 495 

Tyr Gly Tyr Pro Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser
            500                 505                 510 

Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Thr Ile Arg Glu Ile
        515                 520                 525 

Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe
    530                 535                 540 

Tyr Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545                 550                 555                 560 

Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
                565                 570                 575 

Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys
            580                 585                 590 

Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly Leu
        595                 600                 605 

Glu Ile Val Arg Arg Asp Trp Ser Asp Ile Ala Lys Glu Thr Gln Ala
    610                 615                 620 

Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Lys Ala Val
625                 630                 635                 640 

Lys Ile Val Lys Glu Ile Thr Glu Lys Leu Ser Lys Tyr Glu Ile Pro
                645                 650                 655 

Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp
            660                 665                 670 

Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala
        675                 680                 685 

Arg Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile Val Leu
    690                 695                 700 

Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705                 710                 715                 720 

Asp Pro Thr Lys His Lys Tyr Asp Ala Asp Tyr Tyr Ile Glu Asn Gln
                725                 730                 735 

Val Leu Pro Ala Val Met Arg Ile Leu Glu Ala Phe Gly Tyr Lys Lys
            740                 745                 750 

Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp
        755                 760                 765 

Leu Lys Pro Lys Lys
    770            


<210>    25
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    primer


<400>    25
atgctcgcct ttgccatcga gacgctctac cacgagggc                                39


<210>    26
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    primer


<400>    26
ctcattacct acgacggcga caactttgac tttgcttac                                39


<210>    27
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    primer


<400>    27
attacctaca acgacgacaa ctttgacttt gcttacctc                                39


<210>    28
<211>    36
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    primer


<400>    28
acctacaacg gcgccaactt tgactttgct tacctc                                   36


<210>    29
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    primer


<400>    29
tacaacggcg acgcctttga ctttgcttac ctc                                      33


<210>    30
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    primer


<400>    30
tacaacggcg acgactttga ctttgcttac ctc                                      33


<210>    31
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    primer


<400>    31
tacaacggcg acgagtttga ctttgcttac ctc                                      33


<210>    32
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    primer


<400>    32
tacaacggcg acttctttga ctttgcttac ctc                                      33


<210>    33
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    primer


<400>    33
tacaacggcg accgctttga ctttgcttac ctc                                      33


<210>    34
<211>    38
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    primer


<400>    34
aacggcgaca acgacgactt tgcttacctc aaaaaacg                                 38


<210>    35
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    primer


<400>    35
ggcgacaact ttgcctttgc ttacctcaaa aaacgttgc                                39


<210>    36
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    primer


<400>    36
cgcgttgcgc gcttctctat ggaagatgca aaggcaacc                                39
