
                                SEQUENCE LISTING

<110> ILLUMINGEN BIOSCIENCES, INC.,  et al.

<120> PHARMACEUTICAL MANUFACTURING METHODS
  

<130> 55382-75

<150> 60/835,078          
<151> 2006-08-01  

<160> 16

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1038
<212> DNA
<213> Homo sapiens

<400> 1
atggatttgc gtaacacccc agcaaaaagc cttgataaat ttattgaaga ttatttactg 60
cctgatactt gttttcgcat gcaaatcaac catgcaatcg atatcatttg tggattttta 120
aaagaacgtt gctttcgtgg ctcgtcatac ccagtctgtg ttagcaaagt cgtcaaaggc 180
ggttcctcag gaaaaggcac caccctccgc ggtcgttcag atgccgattt agtcgttttt 240
ttatcccctc ttacaacgtt ccaagatcaa cttaatcgtc gtggtgaatt tattcaagaa 300
attcgtcgtc aattggaagc atgtcaacgc gagcgcgcct tttctgtcaa atttgaagta 360
caagcaccgc gttggggtaa tcctcgtgcc ctctcatttg ttttaagctc tttacaatta 420
ggcgaaggcg tggaatttga tgtcctccct gcatttgatg cacttggtca gttaaccggt 480
ggctacaaac ctaaccctca gatctatgtg aaattaatcg aagaatgtac cgacctgcag 540
aaagaaggag aatttagcac ctgctttacg gaactgcaac gtgatttcct caaacaacgt 600
cccactaaac tcaaatcatt gattcgtctt gttaaacact ggtatcaaaa ttgcaaaaaa 660
aaacttggaa aactgccccc acaatacgca ctggaacttc ttaccgtata tgcatgggaa 720
cgtggctcta tgaaaacgca ttttaatacc gcccaaggtt ttcgtactgt attagaatta 780
gtaatcaact atcaacaact gtgtatctat tggaccaaat actatgattt taaaaaccct 840
attatcgaaa aatatttacg tcgtcagctt accaaacctc gtcctgtaat tttagacccg 900
gcagacccta caggtaatct tggtggcggt gatccaaaag gctggcgcca actcgctcag 960
gaagcagaag cgtggctcaa ttatccttgt tttaaaaatt gggacggctc cccggtcagc 1020
tcgtggattt tactgtaa                                               1038

<210> 2
<211> 1038
<212> DNA
<213> Homo sapiens

<400> 2
atggatctca gaaatacccc agccaaatct ctggacaagt tcattgaaga ctatctcttg 60
ccagacacgt gtttccgcat gcaaatcaac catgccattg acatcatctg tgggttcctg 120
aaggaaaggt gcttccgagg tagctcctac cctgtgtgtg tgtccaaggt ggtaaagggt 180
ggctcctcag gcaagggcac caccctcaga ggccgatctg acgctgacct ggttgtcttc 240
ctcagtcctc tcaccacttt tcaggatcag ttaaatcgcc ggggagagtt catccaggaa 300
attaggagac agctggaagc ctgtcaaaga gagagagcat tttccgtgaa gtttgaggtc 360
caggctccac gctggggcaa cccccgtgcg ctcagcttcg tactgagttc gctccagctc 420
ggggaggggg tggagttcga tgtgctgcct gcctttgatg ccctgggtca gttgactggc 480
ggctataaac ctaaccccca aatctatgtc aagctcatcg aggagtgcac cgacctgcag 540
aaagagggcg agttctccac ctgcttcaca gaactacaga gagacttcct gaagcagcgc 600
cccaccaagc tcaagagcct catccgccta gtcaagcact ggtaccaaaa ttgtaagaag 660
aagcttggga agctgccacc tcagtatgcc ctggagctcc tgacggtcta tgcttgggag 720
cgagggagca tgaaaacaca tttcaacaca gcccagggat ttcggacggt cttggaatta 780
gtcataaact accagcaact ctgcatctac tggacaaagt attatgactt taaaaacccc 840
attattgaaa agtacctgag aaggcagctc acgaaaccca ggcctgtgat cctggacccg 900
gcggacccta caggaaactt gggtggtgga gacccaaagg gttggaggca gctggcacaa 960
gaggctgagg cctggctgaa ttacccatgc tttaagaatt gggatgggtc cccagtgagc 1020
tcctggattc tgctgtga                                               1038

<210> 3
<211> 1038
<212> DNA
<213> Homo sapiens

<400> 3
atggatttgc gtaacacccc agcaaaaagc cttgataaat ttattgaaga ttatttactg 60
cctgatactt cttttcgcat gcaaatcaac catgcaatcg atatcatttc cggattttta 120
aaagaacgtt gctttcgtgg ctcgtcatac ccagtctctg ttagcaaagt cgtcaaaggc 180
ggttcctcag gaaaaggcac caccctccgc ggtcgttcag atgccgattt agtcgttttt 240
ttatcccctc ttacaacgtt ccaagatcaa cttaatcgtc gtggtgaatt tattcaagaa 300
attcgtcgtc aattggaagc atgtcaacgc gagcgcgcct tttctgtcaa atttgaagta 360
caagcaccgc gttggggtaa tcctcgtgcc ctctcatttg ttttaagctc tttacaatta 420
ggcgaaggcg tggaatttga tgtcctccct gcatttgatg cacttggtca gttaaccggt 480
ggctacaaac ctaaccctca gatctatgtg aaattaatcg aagaatgtac cgacctgcag 540
aaagaaggag aatttagcac ctgctttacg gaactgcaac gtgatttcct caaacaacgt 600
cccactaaac tcaaatcatt gattcgtctt gttaaacact ggtatcaaaa ttgcaaaaaa 660
aaacttggaa aactgccccc acaatacgca ctggaacttc ttaccgtata tgcatgggaa 720
cgtggctcta tgaaaacgca ttttaatacc gcccaaggtt ttcgtactgt attagaatta 780
gtaatcaact atcaacaact gtgtatctat tggaccaaat actatgattt taaaaaccct 840
attatcgaaa aatatttacg tcgtcagctt accaaacctc gtcctgtaat tttagacccg 900
gcagacccta caggtaatct tggtggcggt gatccaaaag gctggcgcca actcgctcag 960
gaagcagaag cgtggctcaa ttatccttgt tttaaaaatt gggacggctc cccggtcagc 1020
tcgtggattt tactgtaa                                               1038

<210> 4
<211> 1095
<212> DNA
<213> Homo sapiens

<400> 4
atgatggatc tcagaaatac cccagccaaa tctctggaca agttcattga agactatctc 60
ttgccagaca cgtgtttccg catgcaaatc aaccatgcca ttgacatcat ctgtgggttc 120
ctgaaggaaa ggtgcttccg aggtagctcc taccctgtgt gtgtgtccaa ggtggtaaag 180
ggtggctcct caggcaaggg caccaccctc agaggccgat ctgacgctga cctggttgtc 240
ttcctcagtc ctctcaccac ttttcaggat cagttaaatc gccggggaga gttcatccag 300
gaaattagga gacagctgga agcctgtcaa agagagagag cattttccgt gaagtttgag 360
gtccaggctc cacgctgggg caacccccgt gcgctcagct tcgtactgag ttcgctccag 420
ctcggggagg gggtggagtt cgatgtgctg cctgcctttg atgccctggg tcagttgact 480
ggcggctata aacctaaccc ccaaatctat gtcaagctca tcgaggagtg caccgacctg 540
cagaaagagg gcgagttctc cacctgcttc acagaactac agagagactt cctgaagcag 600
cgccccacca agctcaagag cctcatccgc ctagtcaagc actggtacca aaattgtaag 660
aagaagcttg ggaagctgcc acctcagtat gccctggagc tcctgacggt ctatgcttgg 720
gagcgaggga gcatgaaaac acatttcaac acagcccagg gatttcggac ggtcttggaa 780
ttagtcataa actaccagca actctgcatc tactggacaa agtattatga ctttaaaaac 840
cccattattg aaaagtacct gagaaggcag ctcacgaaac ccaggcctgt gatcctggac 900
ccggcggacc ctacaggaaa cttgggtggt ggagacccaa agggttggag gcagctggca 960
caagaggctg aggcctggct gaattaccca tgctttaaga attgggatgg gtccccagtg 1020
agctcctgga ttctgctggt gagacctcct gcttcctccc tgccattcat ccctgcccct 1080
ctccatgaag cttga                                                  1095

<210> 5
<211> 1203
<212> DNA
<213> Homo sapiens

<400> 5
atgatggatc tcagaaatac cccagccaaa tctctggaca agttcattga agactatctc 60
ttgccagaca cgtgtttccg catgcaaatc aaccatgcca ttgacatcat ctgtgggttc 120
ctgaaggaaa ggtgcttccg aggtagctcc taccctgtgt gtgtgtccaa ggtggtaaag 180
ggtggctcct caggcaaggg caccaccctc agaggccgat ctgacgctga cctggttgtc 240
ttcctcagtc ctctcaccac ttttcaggat cagttaaatc gccggggaga gttcatccag 300
gaaattagga gacagctgga agcctgtcaa agagagagag cattttccgt gaagtttgag 360
gtccaggctc cacgctgggg caacccccgt gcgctcagct tcgtactgag ttcgctccag 420
ctcggggagg gggtggagtt cgatgtgctg cctgcctttg atgccctggg tcagttgact 480
ggcggctata aacctaaccc ccaaatctat gtcaagctca tcgaggagtg caccgacctg 540
cagaaagagg gcgagttctc cacctgcttc acagaactac agagagactt cctgaagcag 600
cgccccacca agctcaagag cctcatccgc ctagtcaagc actggtacca aaattgtaag 660
aagaagcttg ggaagctgcc acctcagtat gccctggagc tcctgacggt ctatgcttgg 720
gagcgaggga gcatgaaaac acatttcaac acagcccagg gatttcggac ggtcttggaa 780
ttagtcataa actaccagca actctgcatc tactggacaa agtattatga ctttaaaaac 840
cccattattg aaaagtacct gagaaggcag ctcacgaaac ccaggcctgt gatcctggac 900
ccggcggacc ctacaggaaa cttgggtggt ggagacccaa agggttggag gcagctggca 960
caagaggctg aggcctggct gaattaccca tgctttaaga attgggatgg gtccccagtg 1020
agctcctgga ttctgctggc tgaaagcaac agtgcagacg atgagaccga cgatcccagg 1080
aggtatcaga aatatggtta cattggaaca catgagtacc ctcatttctc tcatagaccc 1140
agcacactcc aggcagcatc caccccacag gcagaagagg actggacctg caccatcctc 1200
tga                                                               1203

<210> 6
<211> 1380
<212> DNA
<213> Homo sapiens

<400> 6
atgatggatc tcagaaatac cccagccaaa tctctggaca agttcattga agactatctc 60
ttgccagaca cgtgtttccg catgcaaatc aaccatgcca ttgacatcat ctgtgggttc 120
ctgaaggaaa ggtgcttccg aggtagctcc taccctgtgt gtgtgtccaa ggtggtaaag 180
ggtggctcct caggcaaggg caccaccctc agaggccgat ctgacgctga cctggttgtc 240
ttcctcagtc ctctcaccac ttttcaggat cagttaaatc gccggggaga gttcatccag 300
gaaattagga gacagctgga agcctgtcaa agagagagag cattttccgt gaagtttgag 360
gtccaggctc cacgctgggg caacccccgt gcgctcagct tcgtactgag ttcgctccag 420
ctcggggagg gggtggagtt cgatgtgctg cctgcctttg atgccctggg tcagttgact 480
ggcggctata aacctaaccc ccaaatctat gtcaagctca tcgaggagtg caccgacctg 540
cagaaagagg gcgagttctc cacctgcttc acagaactac agagagactt cctgaagcag 600
cgccccacca agctcaagag cctcatccgc ctagtcaagc actggtacca aaattgtaag 660
aagaagcttg ggaagctgcc acctcagtat gccctggagc tcctgacggt ctatgcttgg 720
gagcgaggga gcatgaaaac acatttcaac acagcccagg gatttcggac ggtcttggaa 780
ttagtcataa actaccagca actctgcatc tactggacaa agtattatga ctttaaaaac 840
cccattattg aaaagtacct gagaaggcag ctcacgaaac ccaggcctgt gatcctggac 900
ccggcggacc ctacaggaaa cttgggtggt ggagacccaa agggttggag gcagctggca 960
caagaggctg aggcctggct gaattaccca tgctttaaga attgggatgg gtccccagtg 1020
agctcctgga ttctgctgct gaaagcaaca gtacagacga tgagaccgac gatcccagga 1080
cgtatcagaa atatggttac attggaacac atgagtaccc tcatttctct catagaccca 1140
gcacactcca ggcagcatcc accccacagg cagaagagga ctggacctgc accatcctct 1200
gaatgccagt gcatcttggg ggaaagggct ccagtgttat ctggaccagt tccttcattt 1260
tcaggtggga ctcttgatcc agagargaca aagctcctca gtgagctggt gtataatcca 1320
ggacagaacc caggtctcct gactcctggc cttctatgcc ctctatccta tcatagataa 1380


<210> 7
<211> 1155
<212> DNA
<213> Homo sapiens

<400> 7
atgatggatc tcagaaatac cccagccaaa tctctggaca agttcattga agactatctc 60
ttgccagaca cgtgtttccg catgcaaatc aaccatgcca ttgacatcat ctgtgggttc 120
ctgaaggaaa ggtgcttccg aggtagctcc taccctgtgt gtgtgtccaa ggtggtaaag 180
ggtggctcct caggcaaggg caccaccctc agaggccgat ctgacgctga cctggttgtc 240
ttcctcagtc ctctcaccac ttttcaggat cagttaaatc gccggggaga gttcatccag 300
gaaattagga gacagctgga agcctgtcaa agagagagag cattttccgt gaagtttgag 360
gtccaggctc cacgctgggg caacccccgt gcgctcagct tcgtactgag ttcgctccag 420
ctcggggagg gggtggagtt cgatgtgctg cctgcctttg atgccctggg tcagttgact 480
ggcggctata aacctaaccc ccaaatctat gtcaagctca tcgaggagtg caccgacctg 540
cagaaagagg gcgagttctc cacctgcttc acagaactac agagagactt cctgaagcag 600
cgccccacca agctcaagag cctcatccgc ctagtcaagc actggtacca aaattgtaag 660
aagaagcttg ggaagctgcc acctcagtat gccctggagc tcctgacggt ctatgcttgg 720
gagcgaggga gcatgaaaac acatttcaac acagcccagg gatttcggac ggtcttggaa 780
ttagtcataa actaccagca actctgcatc tactggacaa agtattatga ctttaaaaac 840
cccattattg aaaagtacct gagaaggcag ctcacgaaac ccaggcctgt gatcctggac 900
ccggcggacc ctacaggaaa cttgggtggt ggagacccaa agggttggag gcagctggca 960
caagaggctg aggcctggct gaattaccca tgctttaaga attgggatgg gtccccagtg 1020
agctcctgga ttctgctgat gagacaaagg ctcagagagg tgaggtcact tgctcaagga 1080
catcagctaa caagtggtgg aaatggaatt caagctcagt ggactctaaa gccagtgctc 1140
atgtcactgt gctaa                                                  1155

<210> 8
<211> 1244
<212> DNA
<213> Homo sapiens

<400> 8
atgatggatc tcagaaatac cccagccaaa tctctggaca agttcattga agactatctc 60
ttgccagaca cgtgtttccg catgcaaatc aaccatgcca ttgacatcat ctgtgggttc 120
ctgaaggaaa ggtgcttccg aggtagctcc taccctgtgt gtgtgtccaa ggtggtaaag 180
ggtggctcct caggcaaggg caccaccctc agaggccgat ctgacgctga cctggttgtc 240
ttcctcagtc ctctcaccac ttttcaggat cagttaaatc gccggggaga gttcatccag 300
gaaattagga gacagctgga agcctgtcaa agagagagag cattttccgt gaagtttgag 360
gtccaggctc cacgctgggg caacccccgt gcgctcagct tcgtactgag ttcgctccag 420
ctcggggagg gggtggagtt cgatgtgctg cctgcctttg atgccctggg tcagttgact 480
ggcggctata aacctaaccc ccaaatctat gtcaagctca tcgaggagtg caccgacctg 540
cagaaagagg gcgagttctc cacctgcttc acagaactac agagagactt cctgaagcag 600
cgccccacca agctcaagag cctcatccgc ctagtcaagc actggtacca aaattgtaag 660
aagaagcttg ggaagctgcc acctcagtat gccctggagc tcctgacggt ctatgcttgg 720
gagcgaggga gcatgaaaac acatttcaac acagcccagg gatttcggac ggtcttggaa 780
ttagtcataa actaccagca actctgcatc tactggacaa agtattatga ctttaaaaac 840
cccattattg aaaagtacct gagaaggcag ctcacgaaac ccaggcctgt gatcctggac 900
ccggcggacc ctacaggaaa cttgggtggt ggagacccaa agggttggag gcagctggca 960
caagaggctg aggcctggct gaattaccca tgctttaaga attgggatgg gtccccagtg 1020
agctcctgga ttctgctgac ccagcacact ccaggcagca tccaccccac aggcagaaga 1080
ggactggacc tgcaccatcc tctgaatgcc agtgcatctt gggggaaagg gctccagtgt 1140
tatctggacc agttccttca ttttcaggtg ggactcttga tccagagaag acaaagctcc 1200
tcagtgagct ggtgtataat ccaggacaga acccaggtct ctga                  1244

<210> 9
<211> 346
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Met or -Met (Met deleted)

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = Asn OR Asp

<220> 
<221> VARIANT        
<222> 115
<223> Xaa = Phe OR Leu

<220> 
<221> VARIANT        
<222> 127
<223> Xaa = Gly OR Arg

<220> 
<221> VARIANT        
<222> 162
<223> Xaa = Gly OR Ser


<220> 
<221> VARIANT        
<222> 280
<223> Xaa = Asn OR Thr


<220> 
<221> VARIANT        
<222> (330)...(330)
<223> Xaa = Pro OR Ser


<220> 
<221> VARIANT        
<222> (346)...(346)
<223> Xaa = Leu OR -Leu (Leu deleted)

<400> 9
Xaa Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile
 1               5                  10                  15      
Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Xaa His
            20                  25                  30          
Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly
        35                  40                  45              
Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser
    50                  55                  60                  
Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val
65                  70                  75                  80  
Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly
                85                  90                  95      
Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu
            100                 105                 110         
Arg Ala Xaa Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Xaa Asn
        115                 120                 125             
Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly
    130                 135                 140                 
Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr
145                 150                 155                 160 
Gly Xaa Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu
                165                 170                 175     
Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu
            180                 185                 190         
Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu
        195                 200                 205             
Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly
    210                 215                 220                 
Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp
225                 230                 235                 240 
Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg
                245                 250                 255     
Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp
            260                 265                 270         
Thr Lys Tyr Tyr Asp Phe Lys Xaa Pro Ile Ile Glu Lys Tyr Leu Arg
        275                 280                 285             
Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro
    290                 295                 300                 
Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala
305                 310                 315                 320 
Gln Glu Ala Glu Ala Trp Leu Asn Tyr Xaa Cys Phe Lys Asn Trp Asp
                325                 330                 335     
Gly Ser Pro Val Ser Ser Trp Ile Leu Xaa
            340                 345     


<210> 10
<211> 346
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Met OR -Met (Met deleted)

<220> 
<221> VARIANT        
<222> 25
<223> Xaa = Ser OR Cys

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = Asn OR Asp

<220> 
<221> VARIANT        
<222> 38
<223> Xaa = Ser OR Cys

<220> 
<221> VARIANT        
<222> 54
<223> Xaa = Ser OR Cys


<220> 
<221> VARIANT        
<222> 115
<223> Xaa = Phe OR Leu


<220> 
<221> VARIANT        
<222> (127)...(127)
<223> Xaa = Gly OR Arg


<220> 
<221> VARIANT        
<222> (162)...(162)
<223> Xaa = Gly OR Ser


<220> 
<221> VARIANT        
<222> (280)...(280)
<223> Xaa = Asn OR Thr


<220> 
<221> VARIANT        
<222> (330)...(330)
<223> Xaa = Pro OR Ser


<220> 
<221> VARIANT        
<222> (346)...(346)
<223> Xaa = Leu OR -Leu (Leu deleted)

<400> 10
Xaa Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile
 1               5                  10                  15      
Glu Asp Tyr Leu Leu Pro Asp Thr Xaa Phe Arg Met Gln Ile Xaa His
            20                  25                  30          
Ala Ile Asp Ile Ile Xaa Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly
        35                  40                  45              
Ser Ser Tyr Pro Val Xaa Val Ser Lys Val Val Lys Gly Gly Ser Ser
    50                  55                  60                  
Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val
65                  70                  75                  80  
Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly
                85                  90                  95      
Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu
            100                 105                 110         
Arg Ala Xaa Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Xaa Asn
        115                 120                 125             
Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly
    130                 135                 140                 
Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr
145                 150                 155                 160 
Gly Xaa Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu
                165                 170                 175     
Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu
            180                 185                 190         
Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu
        195                 200                 205             
Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly
    210                 215                 220                 
Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp
225                 230                 235                 240 
Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg
                245                 250                 255     
Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp
            260                 265                 270         
Thr Lys Tyr Tyr Asp Phe Lys Xaa Pro Ile Ile Glu Lys Tyr Leu Arg
        275                 280                 285             
Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro
    290                 295                 300                 
Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala
305                 310                 315                 320 
Gln Glu Ala Glu Ala Trp Leu Asn Tyr Xaa Cys Phe Lys Asn Trp Asp
                325                 330                 335     
Gly Ser Pro Val Ser Ser Trp Ile Leu Xaa
            340                 345     


<210> 11
<211> 364
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = Asp OR Asn

<220> 
<221> VARIANT        
<222> 115
<223> Xaa = Leu OR Phe

<220> 
<221> VARIANT        
<222> 127
<223> Xaa = Gly OR Arg

<220> 
<221> VARIANT        
<222> 162
<223> Xaa = Ser OR Gly

<220> 
<221> VARIANT        
<222> 280
<223> Xaa = Asn OR Thr


<220> 
<221> VARIANT        
<222> 330
<223> Xaa = Pro OR Ser

<400> 11
Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile
 1               5                  10                  15      
Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Xaa His
            20                  25                  30          
Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly
        35                  40                  45              
Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser
    50                  55                  60                  
Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val
65                  70                  75                  80  
Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly
                85                  90                  95      
Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu
            100                 105                 110         
Arg Ala Xaa Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Xaa Asn
        115                 120                 125             
Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly
    130                 135                 140                 
Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr
145                 150                 155                 160 
Gly Xaa Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu
                165                 170                 175     
Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu
            180                 185                 190         
Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu
        195                 200                 205             
Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly
    210                 215                 220                 
Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp
225                 230                 235                 240 
Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg
                245                 250                 255     
Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp
            260                 265                 270         
Thr Lys Tyr Tyr Asp Phe Lys Xaa Pro Ile Ile Glu Lys Tyr Leu Arg
        275                 280                 285             
Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro
    290                 295                 300                 
Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala
305                 310                 315                 320 
Gln Glu Ala Glu Ala Trp Leu Asn Tyr Xaa Cys Phe Lys Asn Trp Asp
                325                 330                 335     
Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Val Arg Pro Pro Ala Ser
            340                 345                 350         
Ser Leu Pro Phe Ile Pro Ala Pro Leu His Glu Ala
        355                 360                 


<210> 12
<211> 400
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = Asp OR Asn

<220> 
<221> VARIANT        
<222> 115
<223> Xaa = Leu OR Phe

<220> 
<221> VARIANT        
<222> 127
<223> Xaa = Gly OR Arg

<220> 
<221> VARIANT        
<222> 162
<223> Xaa = Ser OR Gly

<220> 
<221> VARIANT        
<222> 280
<223> Xaa = Asn OR Thr


<220> 
<221> VARIANT        
<222> 330
<223> Xaa = Pro OR Ser


<220> 
<221> VARIANT        
<222> (352)...(352)
<223> Xaa = Ala OR Thr


<220> 
<221> VARIANT        
<222> (361)...(361)
<223> Xaa = Arg OR Thr

<400> 12
Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile
 1               5                  10                  15      
Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Xaa His
            20                  25                  30          
Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly
        35                  40                  45              
Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser
    50                  55                  60                  
Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val
65                  70                  75                  80  
Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly
                85                  90                  95      
Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu
            100                 105                 110         
Arg Ala Xaa Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Xaa Asn
        115                 120                 125             
Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly
    130                 135                 140                 
Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr
145                 150                 155                 160 
Gly Xaa Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu
                165                 170                 175     
Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu
            180                 185                 190         
Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu
        195                 200                 205             
Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly
    210                 215                 220                 
Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp
225                 230                 235                 240 
Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg
                245                 250                 255     
Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp
            260                 265                 270         
Thr Lys Tyr Tyr Asp Phe Lys Xaa Pro Ile Ile Glu Lys Tyr Leu Arg
        275                 280                 285             
Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro
    290                 295                 300                 
Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala
305                 310                 315                 320 
Gln Glu Ala Glu Ala Trp Leu Asn Tyr Xaa Cys Phe Lys Asn Trp Asp
                325                 330                 335     
Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Ala Glu Ser Asn Ser Xaa
            340                 345                 350         
Asp Asp Glu Thr Asp Asp Pro Arg Xaa Tyr Gln Lys Tyr Gly Tyr Ile
        355                 360                 365             
Gly Thr His Glu Tyr Pro His Phe Ser His Arg Pro Ser Thr Leu Gln
    370                 375                 380                 
Ala Ala Ser Thr Pro Gln Ala Glu Glu Asp Trp Thr Cys Thr Ile Leu
385                 390                 395                 400 


<210> 13
<211> 384
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = Asp OR Asn

<220> 
<221> VARIANT        
<222> 115
<223> Xaa = Leu OR Phe

<220> 
<221> VARIANT        
<222> 127
<223> Xaa = Gly OR Arg

<220> 
<221> VARIANT        
<222> 162
<223> Xaa = Ser OR Gly

<220> 
<221> VARIANT        
<222> 280
<223> Xaa = Asn OR Thr


<220> 
<221> VARIANT        
<222> 330
<223> Xaa = Pro OR Ser

<400> 13
Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile
 1               5                  10                  15      
Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Xaa His
            20                  25                  30          
Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly
        35                  40                  45              
Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser
    50                  55                  60                  
Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val
65                  70                  75                  80  
Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly
                85                  90                  95      
Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu
            100                 105                 110         
Arg Ala Xaa Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Xaa Asn
        115                 120                 125             
Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly
    130                 135                 140                 
Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr
145                 150                 155                 160 
Gly Xaa Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu
                165                 170                 175     
Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu
            180                 185                 190         
Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu
        195                 200                 205             
Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly
    210                 215                 220                 
Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp
225                 230                 235                 240 
Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg
                245                 250                 255     
Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp
            260                 265                 270         
Thr Lys Tyr Tyr Asp Phe Lys Xaa Pro Ile Ile Glu Lys Tyr Leu Arg
        275                 280                 285             
Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro
    290                 295                 300                 
Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala
305                 310                 315                 320 
Gln Glu Ala Glu Ala Trp Leu Asn Tyr Xaa Cys Phe Lys Asn Trp Asp
                325                 330                 335     
Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Met Arg Gln Arg Leu Arg
            340                 345                 350         
Glu Val Arg Ser Leu Ala Gln Gly His Gln Leu Thr Ser Gly Gly Asn
        355                 360                 365             
Gly Ile Gln Ala Gln Trp Thr Leu Lys Pro Val Leu Met Ser Leu Cys
    370                 375                 380                 


<210> 14
<211> 459
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = Asp OR Asn

<220> 
<221> VARIANT        
<222> 115
<223> Xaa = Leu OR Phe

<220> 
<221> VARIANT        
<222> 127
<223> Xaa = Gly OR Arg

<220> 
<221> VARIANT        
<222> 162
<223> Xaa = Ser OR Gly

<220> 
<221> VARIANT        
<222> 280
<223> Xaa = Asn OR Thr


<220> 
<221> VARIANT        
<222> 330
<223> Xaa = Pro OR Ser


<220> 
<221> VARIANT        
<222> (361)...(361)
<223> Xaa = Gly OR Arg


<220> 
<221> VARIANT        
<222> (429)...(429)
<223> Xaa = Lys OR Arg

<400> 14
Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile
 1               5                  10                  15      
Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Xaa His
            20                  25                  30          
Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly
        35                  40                  45              
Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser
    50                  55                  60                  
Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val
65                  70                  75                  80  
Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly
                85                  90                  95      
Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu
            100                 105                 110         
Arg Ala Xaa Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Xaa Asn
        115                 120                 125             
Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly
    130                 135                 140                 
Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr
145                 150                 155                 160 
Gly Xaa Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu
                165                 170                 175     
Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu
            180                 185                 190         
Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu
        195                 200                 205             
Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly
    210                 215                 220                 
Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp
225                 230                 235                 240 
Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg
                245                 250                 255     
Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp
            260                 265                 270         
Thr Lys Tyr Tyr Asp Phe Lys Xaa Pro Ile Ile Glu Lys Tyr Leu Arg
        275                 280                 285             
Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro
    290                 295                 300                 
Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala
305                 310                 315                 320 
Gln Glu Ala Glu Ala Trp Leu Asn Tyr Xaa Cys Phe Lys Asn Trp Asp
                325                 330                 335     
Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Leu Lys Ala Thr Val Gln
            340                 345                 350         
Thr Met Arg Pro Thr Ile Pro Gly Xaa Ile Arg Asn Met Val Thr Leu
        355                 360                 365             
Glu His Met Ser Thr Leu Ile Ser Leu Ile Asp Pro Ala His Ser Arg
    370                 375                 380                 
Gln His Pro Pro His Arg Gln Lys Arg Thr Gly Pro Ala Pro Ser Ser
385                 390                 395                 400 
Glu Cys Gln Cys Ile Leu Gly Glu Arg Ala Pro Val Leu Ser Gly Pro
                405                 410                 415     
Val Pro Ser Phe Ser Gly Gly Thr Leu Asp Pro Glu Xaa Thr Lys Leu
            420                 425                 430         
Leu Ser Glu Leu Val Tyr Asn Pro Gly Gln Asn Pro Gly Leu Leu Thr
        435                 440                 445             
Pro Gly Leu Leu Cys Pro Leu Ser Tyr His Arg
    450                 455                 


<210> 15
<211> 414
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = Asp OR Asn

<220> 
<221> VARIANT        
<222> 115
<223> Xaa = Leu OR Phe

<220> 
<221> VARIANT        
<222> 127
<223> Xaa = Gly OR Arg

<220> 
<221> VARIANT        
<222> 162
<223> Xaa = Ser OR Gly

<220> 
<221> VARIANT        
<222> 280
<223> Xaa = Asn OR Thr


<220> 
<221> VARIANT        
<222> 330
<223> Xaa = Pro OR Ser


<220> 
<221> VARIANT        
<222> (397)...(397)
<223> Xaa = Gly OR Arg

<400> 15
Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile
 1               5                  10                  15      
Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Xaa His
            20                  25                  30          
Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly
        35                  40                  45              
Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser
    50                  55                  60                  
Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val
65                  70                  75                  80  
Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly
                85                  90                  95      
Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu
            100                 105                 110         
Arg Ala Xaa Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Xaa Asn
        115                 120                 125             
Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly
    130                 135                 140                 
Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr
145                 150                 155                 160 
Gly Xaa Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu
                165                 170                 175     
Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu
            180                 185                 190         
Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu
        195                 200                 205             
Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly
    210                 215                 220                 
Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp
225                 230                 235                 240 
Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg
                245                 250                 255     
Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp
            260                 265                 270         
Thr Lys Tyr Tyr Asp Phe Lys Xaa Pro Ile Ile Glu Lys Tyr Leu Arg
        275                 280                 285             
Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro
    290                 295                 300                 
Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala
305                 310                 315                 320 
Gln Glu Ala Glu Ala Trp Leu Asn Tyr Xaa Cys Phe Lys Asn Trp Asp
                325                 330                 335     
Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Thr Gln His Thr Pro Gly
            340                 345                 350         
Ser Ile His Pro Thr Gly Arg Arg Gly Leu Asp Leu His His Pro Leu
        355                 360                 365             
Asn Ala Ser Ala Ser Trp Gly Lys Gly Leu Gln Cys Tyr Leu Asp Gln
    370                 375                 380                 
Phe Leu His Phe Gln Val Gly Leu Leu Ile Gln Arg Xaa Gln Ser Ser
385                 390                 395                 400 
Ser Val Ser Trp Cys Ile Ile Gln Asp Arg Thr Gln Val Ser
                405                 410                 


<210> 16
<211> 334
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Met or -Met (Met deleted)

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = Asn OR Asp

<220> 
<221> VARIANT        
<222> 115
<223> Xaa = Phe OR Leu

<220> 
<221> VARIANT        
<222> 127
<223> Xaa = Gly OR Arg

<220> 
<221> VARIANT        
<222> 162
<223> Xaa = Gly OR Ser


<220> 
<221> VARIANT        
<222> 280
<223> Xaa = Asn OR Thr


<220> 
<221> VARIANT        
<222> (330)...(330)
<223> Xaa = Pro OR Ser

<400> 16
Xaa Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile
 1               5                  10                  15      
Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Xaa His
            20                  25                  30          
Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly
        35                  40                  45              
Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser
    50                  55                  60                  
Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val
65                  70                  75                  80  
Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly
                85                  90                  95      
Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu
            100                 105                 110         
Arg Ala Xaa Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Xaa Asn
        115                 120                 125             
Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly
    130                 135                 140                 
Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr
145                 150                 155                 160 
Gly Xaa Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu
                165                 170                 175     
Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu
            180                 185                 190         
Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu
        195                 200                 205             
Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly
    210                 215                 220                 
Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp
225                 230                 235                 240 
Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg
                245                 250                 255     
Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp
            260                 265                 270         
Thr Lys Tyr Tyr Asp Phe Lys Xaa Pro Ile Ile Glu Lys Tyr Leu Arg
        275                 280                 285             
Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro
    290                 295                 300                 
Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala
305                 310                 315                 320 
Gln Glu Ala Glu Ala Trp Leu Asn Tyr Xaa Cys Phe Lys Asn
                325                 330                 

