                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  Methods of Treating, Diagnosing or Detecting Cancer

<130>  28266.0002 (27527/42120)

<150>  60/858,882
<151>  2006-11-14

<160>  29    

<170>  PatentIn version 3.4

<210>  1
<211>  1746
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
atgcagcgcc cgggcccccg cctgtggctg gtcctgcagg tgatgggctc gtgcgccgcc     60

atcagctcca tggacatgga gcgcccgggc gacggcaaat gccagcccat cgagatcccg    120

atgtgcaagg acatcggcta caacatgact cgtatgccca acctgatggg ccacgagaac    180

cagcgcgagg cagccatcca gttgcacgag ttcgcgccgc tggtggagta cggctgccac    240

ggccacctcc gcttcttcct gtgctcgctg tacgcgccga tgtgcaccga gcaggtctct    300

acccccatcc ccgcctgccg ggtcatgtgc gagcaggccc ggctcaagtg ctccccgatt    360

atggagcagt tcaacttcaa gtggcccgac tccctggact gccggaaact ccccaacaag    420

aacgacccca actacctgtg catggaggcg cccaacaacg gctcggacga gcccacccgg    480

ggctcgggcc tgttcccgcc gctgttccgg ccgcagcggc cccacagcgc gcaggagcac    540

ccgctgaagg acgggggccc cgggcgcggc ggctgcgaca acccgggcaa gttccaccac    600

gtggagaaga gcgcgtcgtg cgcgccgctc tgcacgcccg gcgtggacgt gtactggagc    660

cgcgaggaca agcgcttcgc agtggtctgg ctggccatct gggcggtgct gtgcttcttc    720

tccagcgcct tcaccgtgct caccttcctc atcgacccgg cccgcttccg ctaccccgag    780

cgccccatca tcttcctctc catgtgctac tgcgtctact ccgtgggcta cctcatccgc    840

ctcttcgccg gcgccgagag catcgcctgc gaccgggaca gcggccagct ctatgtcatc    900

caggagggac tggagagcac cggctgcacg ctggtcttcc tggtcctcta ctacttcggc    960

atggccagct cgctgtggtg ggtggtcctc acgctcacct ggttcctggc cgccggcaag   1020

aagtggggcc acgaggccat cgaagccaac agcagctact tccacctggc agcctgggcc   1080

atcccggcgg tgaagaccat cctgatcctg gtcatgcgca gggtggcggg ggacgagctc   1140

accggggtct gctacgtggg cagcatggac gtcaacgcgc tcaccggctt cgtgctcatt   1200

cccctggcct gctacctggt catcggcacg tccttcatcc tctcgggctt cgtggccctg   1260

ttccacatcc ggagggtgat gaagacgggc ggcgagaaca cggacaagct ggagaagctc   1320

atggtgcgta tcgggctctt ctctgtgctg tacaccgtgc cggccacctg tgtgatcgcc   1380

tgctactttt acgaacgcct caacatggat tactggaaga tcctggcggc gcagcacaag   1440

tgcaaaatga acaaccagac taaaacgctg gactgcctga tggccgcctc catccccgcc   1500

gtggagatct tcatggtgaa gatctttatg ctgctggtgg tggggatcac cagcgggatg   1560

tggatttgga cctccaagac tctgcagtcc tggcagcagg tgtgcagccg taggttaaag   1620

aagaagagcc ggagaaaacc ggccagcgtg atcaccagcg gtgggattta caaaaaagcc   1680

cagcatcccc agaaaactca ccacgggaaa tatgagatcc ctgcccagtc gcccacctgc   1740

gtgtga                                                              1746


<210>  2
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Gln Arg Pro Gly Pro Arg Leu Trp Leu Val Leu Gln Val Met Gly 
1               5                   10                  15      


Ser Cys Ala Ala Ile Ser Ser Met Asp Met Glu Arg Pro Gly Asp Gly 
            20                  25                  30          


Lys Cys Gln Pro Ile Glu Ile Pro Met Cys Lys Asp Ile Gly Tyr Asn 
        35                  40                  45              


Met Thr Arg Met Pro Asn Leu Met Gly His Glu Asn Gln Arg Glu Ala 
    50                  55                  60                  


Ala Ile Gln Leu His Glu Phe Ala Pro Leu Val Glu Tyr Gly Cys His 
65                  70                  75                  80  


Gly His Leu Arg Phe Phe Leu Cys Ser Leu Tyr Ala Pro Met Cys Thr 
                85                  90                  95      


Glu Gln Val Ser Thr Pro Ile Pro Ala Cys Arg Val Met Cys Glu Gln 
            100                 105                 110         


Ala Arg Leu Lys Cys Ser Pro Ile Met Glu Gln Phe Asn Phe Lys Trp 
        115                 120                 125             


Pro Asp Ser Leu Asp Cys Arg Lys Leu Pro Asn Lys Asn Asp Pro Asn 
    130                 135                 140                 


Tyr Leu Cys Met Glu Ala Pro Asn Asn Gly Ser Asp Glu Pro Thr Arg 
145                 150                 155                 160 


Gly Ser Gly Leu Phe Pro Pro Leu Phe Arg Pro Gln Arg Pro His Ser 
                165                 170                 175     


Ala Gln Glu His Pro Leu Lys Asp Gly Gly Pro Gly Arg Gly Gly Cys 
            180                 185                 190         


Asp Asn Pro Gly Lys Phe His His Val Glu Lys Ser Ala Ser Cys Ala 
        195                 200                 205             


Pro Leu Cys Thr Pro Gly Val Asp Val Tyr Trp Ser Arg Glu Asp Lys 
    210                 215                 220                 


Arg Phe Ala Val Val Trp Leu Ala Ile Trp Ala Val Leu Cys Phe Phe 
225                 230                 235                 240 


Ser Ser Ala Phe Thr Val Leu Thr Phe Leu Ile Asp Pro Ala Arg Phe 
                245                 250                 255     


Arg Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Met Cys Tyr Cys Val 
            260                 265                 270         


Tyr Ser Val Gly Tyr Leu Ile Arg Leu Phe Ala Gly Ala Glu Ser Ile 
        275                 280                 285             


Ala Cys Asp Arg Asp Ser Gly Gln Leu Tyr Val Ile Gln Glu Gly Leu 
    290                 295                 300                 


Glu Ser Thr Gly Cys Thr Leu Val Phe Leu Val Leu Tyr Tyr Phe Gly 
305                 310                 315                 320 


Met Ala Ser Ser Leu Trp Trp Val Val Leu Thr Leu Thr Trp Phe Leu 
                325                 330                 335     


Ala Ala Gly Lys Lys Trp Gly His Glu Ala Ile Glu Ala Asn Ser Ser 
            340                 345                 350         


Tyr Phe His Leu Ala Ala Trp Ala Ile Pro Ala Val Lys Thr Ile Leu 
        355                 360                 365             


Ile Leu Val Met Arg Arg Val Ala Gly Asp Glu Leu Thr Gly Val Cys 
    370                 375                 380                 


Tyr Val Gly Ser Met Asp Val Asn Ala Leu Thr Gly Phe Val Leu Ile 
385                 390                 395                 400 


Pro Leu Ala Cys Tyr Leu Val Ile Gly Thr Ser Phe Ile Leu Ser Gly 
                405                 410                 415     


Phe Phe His Ile Arg Arg Val Met Lys Thr Gly Gly Glu Asn Thr Asp 
            420                 425                 430         


Lys Leu Glu Lys Leu Met Val Arg Ile Gly Leu Phe Ser Val Leu Tyr 
        435                 440                 445             


Thr Val Pro Ala Thr Cys Val Ile Ala Cys Tyr Phe Tyr Glu Arg Leu 
    450                 455                 460                 


Asn Met Asp Tyr Trp Lys Ile Leu Ala Ala Gln His Lys Cys Lys Met 
465                 470                 475                 480 


Asn Asn Gln Thr Lys Thr Leu Asp Cys Leu Met Ala Ala Ser Ile Pro 
                485                 490                 495     


Ala Val Glu Ile Phe Met Val Lys Ile Phe Met Leu Leu Val Val Gly 
            500                 505                 510         


Ile Thr Ser Gly Met Trp Ile Trp Thr Ser Lys Thr Leu Gln Ser Trp 
        515                 520                 525             


Gln Gln Val Cys Ser Arg Arg Leu Lys Lys Lys Ser Arg Arg Lys Pro 
    530                 535                 540                 


Ala Ser Val Ile Thr Ser Gly Gly Ile Tyr Lys Lys Ala Gln His Pro 
545                 550                 555                 560 


Gln Lys Thr His His Gly Lys Tyr Glu Ile Pro Ala Gln Ser Pro Thr 
                565                 570                 575     


Cys Val 
        


<210>  3
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
cagccgtagg ttaaagaaga a                                               21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
ttcttcttta acctacggct g                                               21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
cccgattatg gagcagttca a                                               21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
ttgaactgct ccataatcgg g                                               21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
caggtgtgca gccgtaggtt a                                               21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
taacctacgg ctgcacacct g                                               21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
acctcacatt tgtgaactca a                                               21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
ttgagttcac aaatgtgagg t                                               21


<210>  11
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
gcacaagtgc aaaatgaac                                                  19


<210>  12
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
gttcattttg cacttgtgc                                                  19


<210>  13
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
cctccatcaa acctcacat                                                  19


<210>  14
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
atgtgaggtt tgatggagg                                                  19


<210>  15
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
tgtgatcgcc tgctactttt t                                               21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
aaaaagtagc aggcgatcac a                                               21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
gcaccgagca ggtctctact t                                               21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
aagtagagac ctgctcggtg c                                               21


<210>  19
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
gatgtggatt tggacctcca agact                                           25


<210>  20
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
agtcttggag gtccaaatcc acatc                                           25


<210>  21
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
agcaggtgtg cagccgtagg ttaaa                                           25


<210>  22
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
tttaacctac ggctgcacac ctgct                                           25


<210>  23
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
ctggtcatgc gcagggt                                                    17


<210>  24
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
ctcaccggct tcgtgctc                                                   18


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
ggcagcatgg acgtcaacgc g                                               21


<210>  26
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
gcacaagtgc aaaatgaac                                                  19


<210>  27
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
agcaggtgtg cagccgtagg ttaaa                                           25


<210>  28
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
gggagcaaau gaaccugaut t                                               21


<210>  29
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
uccaaacugg aucguaagaa ggcag                                           25


