                         SEQUENCE LISTING

<110>  SYNARC
 
<120>  MARQUEUR SPECIFIQUE D'UNE DEGRADATION OXYDATIVE DE TISSUS 
       CONTENANT DU COLLAGENE DE TYPE III, MOYENS ET METHODES, KITS DE 
       DIAGNOTIC DE SUIVI OU DE PRONOSTIC DES PATHOLOGIES CIBLEES PAR CE
        MARQUEUR

<130>  BFF060303

<160>  14    

<170>  PatentIn version 3.3

<210>  1
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Nitrosylation
<222>  (1)..(6)
<223>  Au moins l'un des Tyr est nitrosyl et o Gln correspond non 
       seulement  la glutamine conformment au code international mais 
       aussi  l'acide pyroglutamique

<400>  1

Gln Tyr Asp Ser Tyr Asp 
1               5       


<210>  2
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Nitrosylation
<222>  (1)..(10)
<223>  Xaa correspond  un Tyr Nitrosyl

<400>  2

Gln Xaa Asp Ser Xaa Asp Val Lys Ser Gly 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Nitrosylation
<222>  (1)..(10)
<223>  Xaa correspond  un Tyr Nitrosyl

<400>  3

Gln Xaa Asp Ser Tyr Asp Val Lys Ser Gly 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Nitrosylation
<222>  (1)..(10)
<223>  Xaa correspond  un Tyr Nitrosyl

<400>  4

Gln Tyr Asp Ser Xaa Asp Val Lys Ser Gly 
1               5                   10  


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Nitrosylation
<222>  (1)..(9)
<223>  Xaa correspond  un Tyr Nitrosyl

<400>  5

Gln Xaa Asp Ser Xaa Asp Val Lys Ser 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Nitrosylation
<222>  (1)..(9)
<223>  Xaa correspond  un Tyr Nitrosyl

<400>  6

Gln Xaa Asp Ser Tyr Asp Val Lys Ser 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Nitrosylation
<222>  (1)..(9)
<223>  Xaa correspond  un Tyr Nitrosyl

<400>  7

Gln Tyr Asp Ser Xaa Asp Val Lys Ser 
1               5                   


<210>  8
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Nitrosylation
<222>  (1)..(9)
<223>  Xaa correspond  un Tyr Nitrosyl

<400>  8

Gln Tyr Asp Ser Tyr Asp Val Lys Ser Gly 
1               5                   10  


<210>  9
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  9

Pro Gln Tyr Asp Ser Tyr Asp Val Lys Ser Gly 
1               5                   10      


<210>  10
<211>  1466
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys 
            20                  25                  30          


Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu 
        35                  40                  45              


Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp 
    50                  55                  60                  


Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro 
65                  70                  75                  80  


Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Thr Ala Pro Thr 
                85                  90                  95      


Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile Pro Gly Gln 
        115                 120                 125             


Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys 
    130                 135                 140                 


Pro Thr Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val 
145                 150                 155                 160 


Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala 
                165                 170                 175     


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His Pro Gly 
            180                 185                 190         


Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln 
        195                 200                 205             


Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser 
    210                 215                 220                 


Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly 
225                 230                 235                 240 


Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly Pro Ala Gly Ile 
                245                 250                 255     


Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn 
            260                 265                 270         


Gly Glu Lys Gly Glu Thr Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly 
        275                 280                 285             


Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala 
    290                 295                 300                 


Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg 
305                 310                 315                 320 


Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly 
                325                 330                 335     


Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu 
            340                 345                 350         


Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg 
        355                 360                 365             


Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln Gly Pro Pro Gly 
    370                 375                 380                 


Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro 
385                 390                 395                 400 


Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro 
                405                 410                 415     


Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly 
            420                 425                 430         


Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg Gly Glu 
        435                 440                 445             


Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala Lys Gly Glu Asp 
    450                 455                 460                 


Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly 
465                 470                 475                 480 


Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly Pro Ala Gly Pro 
                485                 490                 495     


Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly 
        515                 520                 525             


Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly 
    530                 535                 540                 


Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Ser 
545                 550                 555                 560 


Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Gln Pro Gly 
                565                 570                 575     


Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys 
            580                 585                 590         


Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Pro 
        595                 600                 605             


Gly Lys Asn Gly Glu Thr Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly 
    610                 615                 620                 


Pro Gly Gly Asp Lys Gly Asp Thr Gly Pro Pro Gly Pro Gln Gly Leu 
625                 630                 635                 640 


Gln Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro 
                645                 650                 655     


Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly 
            660                 665                 670         


Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Leu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu 
    690                 695                 700                 


Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly 
705                 710                 715                 720 


Thr Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Leu Gly Ser 
                725                 730                 735     


Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp 
            740                 745                 750         


Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Thr Gly Pro Ile Gly 
        755                 760                 765             


Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala 
    770                 775                 780                 


Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg 
785                 790                 795                 800 


Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly 
                805                 810                 815     


Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly Ala Pro Gly Glu 
            820                 825                 830         


Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro Pro Gly Gly Ser 
        835                 840                 845             


Gly Pro Ala Gly Pro Pro Gly Pro Gln Gly Val Lys Gly Glu Arg Gly 
    850                 855                 860                 


Ser Pro Gly Gly Pro Gly Ala Ala Gly Phe Pro Gly Ala Arg Gly Leu 
865                 870                 875                 880 


Pro Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro Gly Pro Ser 
                885                 890                 895     


Gly Ser Pro Gly Lys Asp Gly Pro Pro Gly Pro Ala Gly Asn Thr Gly 
            900                 905                 910         


Ala Pro Gly Ser Pro Gly Val Ser Gly Pro Lys Gly Asp Ala Gly Gln 
        915                 920                 925             


Pro Gly Glu Lys Gly Ser Pro Gly Ala Gln Gly Pro Pro Gly Ala Pro 
    930                 935                 940                 


Gly Pro Leu Gly Ile Ala Gly Ile Thr Gly Ala Arg Gly Leu Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Met Pro Gly Pro Arg Gly Ser Pro Gly Pro Gln Gly Val 
                965                 970                 975     


Lys Gly Glu Ser Gly Lys Pro Gly Ala Asn Gly Leu Ser Gly Glu Arg 
            980                 985                 990         


Gly Pro Pro Gly Pro Gln Gly Leu  Pro Gly Leu Ala Gly  Thr Ala Gly 
        995                 1000                 1005             


Glu Pro  Gly Arg Asp Gly Asn  Pro Gly Ser Asp Gly  Leu Pro Gly 
    1010                 1015                 1020             


Arg Asp  Gly Ser Pro Gly Gly  Lys Gly Asp Arg Gly  Glu Asn Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Pro Gly Ala  Pro Gly His Pro Gly  Pro Pro Gly 
    1040                 1045                 1050             


Pro Val  Gly Pro Ala Gly Lys  Ser Gly Asp Arg Gly  Glu Ser Gly 
    1055                 1060                 1065             


Pro Ala  Gly Pro Ala Gly Ala  Pro Gly Pro Ala Gly  Ser Arg Gly 
    1070                 1075                 1080             


Ala Pro  Gly Pro Gln Gly Pro  Arg Gly Asp Lys Gly  Glu Thr Gly 
    1085                 1090                 1095             


Glu Arg  Gly Ala Ala Gly Ile  Lys Gly His Arg Gly  Phe Pro Gly 
    1100                 1105                 1110             


Asn Pro  Gly Ala Pro Gly Ser  Pro Gly Pro Ala Gly  Gln Gln Gly 
    1115                 1120                 1125             


Ala Ile  Gly Ser Pro Gly Pro  Ala Gly Pro Arg Gly  Pro Val Gly 
    1130                 1135                 1140             


Pro Ser  Gly Pro Pro Gly Lys  Asp Gly Thr Ser Gly  His Pro Gly 
    1145                 1150                 1155             


Pro Ile  Gly Pro Pro Gly Pro  Arg Gly Asn Arg Gly  Glu Arg Gly 
    1160                 1165                 1170             


Ser Glu  Gly Ser Pro Gly His  Pro Gly Gln Pro Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Pro  Gly Ala Pro Gly Pro  Cys Cys Gly Gly Val  Gly Ala Ala 
    1190                 1195                 1200             


Ala Ile  Ala Gly Ile Gly Gly  Glu Lys Ala Gly Gly  Phe Ala Pro 
    1205                 1210                 1215             


Tyr Tyr  Gly Asp Glu Pro Met  Asp Phe Lys Ile Asn  Thr Asp Glu 
    1220                 1225                 1230             


Ile Met  Thr Ser Leu Lys Ser  Val Asn Gly Gln Ile  Glu Ser Leu 
    1235                 1240                 1245             


Ile Ser  Pro Asp Gly Ser Arg  Lys Asn Pro Ala Arg  Asn Cys Arg 
    1250                 1255                 1260             


Asp Leu  Lys Phe Cys His Pro  Glu Leu Lys Ser Gly  Glu Tyr Trp 
    1265                 1270                 1275             


Val Asp  Pro Asn Gln Gly Cys  Lys Leu Asp Ala Ile  Lys Val Phe 
    1280                 1285                 1290             


Cys Asn  Met Glu Thr Gly Glu  Thr Cys Ile Ser Ala  Asn Pro Leu 
    1295                 1300                 1305             


Asn Val  Pro Arg Lys His Trp  Trp Thr Asp Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys His  Val Trp Phe Gly Glu  Ser Met Asp Gly Gly  Phe Gln Phe 
    1325                 1330                 1335             


Ser Tyr  Gly Asn Pro Glu Leu  Pro Glu Asp Val Leu  Asp Val Gln 
    1340                 1345                 1350             


Leu Ala  Phe Leu Arg Leu Leu  Ser Ser Arg Ala Ser  Gln Asn Ile 
    1355                 1360                 1365             


Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr Met Asp  Gln Ala Ser 
    1370                 1375                 1380             


Gly Asn  Val Lys Lys Ala Leu  Lys Leu Met Gly Ser  Asn Glu Gly 
    1385                 1390                 1395             


Glu Phe  Lys Ala Glu Gly Asn  Ser Lys Phe Thr Tyr  Thr Val Leu 
    1400                 1405                 1410             


Glu Asp  Gly Cys Thr Lys His  Thr Gly Glu Trp Ser  Lys Thr Val 
    1415                 1420                 1425             


Phe Glu  Tyr Arg Thr Arg Lys  Ala Val Arg Leu Pro  Ile Val Asp 
    1430                 1435                 1440             


Ile Ala  Pro Tyr Asp Ile Gly  Gly Pro Asp Gln Glu  Phe Gly Val 
    1445                 1450                 1455             


Asp Val  Gly Pro Val Cys Phe  Leu 
    1460                 1465     


<210>  11
<211>  607
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(18)

<220>
<221>  PROPEP
<222>  (19)..(24)

<220>
<221>  Nitrosylation
<222>  (24)..(607)
<223>  Xaa est la 3-Nitrotyrosine

<400>  11

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Leu Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Thr His Lys Ser Glu Ile Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu His Phe Lys Gly Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ser Gln Xaa Leu Gln Gln Cys Pro Phe Asp Glu His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Leu Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser His Ala Gly Cys Glu Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Glu Leu Cys Lys Val Ala Ser Leu Arg Glu Thr Xaa Gly Asp Met Ala 
            100                 105                 110         


Asp Cys Cys Glu Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Ser 
        115                 120                 125             


His Lys Asp Asp Ser Pro Asp Leu Pro Lys Leu Lys Pro Asp Pro Asn 
    130                 135                 140                 


Thr Leu Cys Asp Glu Phe Lys Ala Asp Glu Lys Lys Phe Trp Gly Lys 
145                 150                 155                 160 


Xaa Leu Xaa Glu Ile Ala Arg Arg His Pro Xaa Phe Xaa Ala Pro Glu 
                165                 170                 175     


Leu Leu Xaa Xaa Ala Asn Lys Xaa Asn Gly Val Phe Gln Glu Cys Cys 
            180                 185                 190         


Gln Ala Glu Asp Lys Gly Ala Cys Leu Leu Pro Lys Ile Glu Thr Met 
        195                 200                 205             


Arg Glu Lys Val Leu Ala Ser Ser Ala Arg Gln Arg Leu Arg Cys Ala 
    210                 215                 220                 


Ser Ile Gln Lys Phe Gly Glu Arg Ala Leu Lys Ala Trp Ser Val Ala 
225                 230                 235                 240 


Arg Leu Ser Gln Lys Phe Pro Lys Ala Glu Phe Val Glu Val Thr Lys 
                245                 250                 255     


Leu Val Thr Asp Leu Thr Lys Val His Lys Glu Cys Cys His Gly Asp 
            260                 265                 270         


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Xaa Ile Cys 
        275                 280                 285             


Asp Asn Gln Asp Thr Ile Ser Ser Lys Leu Lys Glu Cys Cys Asp Lys 
    290                 295                 300                 


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Lys Asp Ala 
305                 310                 315                 320 


Ile Pro Glu Asn Leu Pro Pro Leu Thr Ala Asp Phe Ala Glu Asp Lys 
                325                 330                 335     


Asp Val Cys Lys Asn Xaa Gln Glu Ala Lys Asp Ala Phe Leu Gly Ser 
            340                 345                 350         


Phe Leu Xaa Glu Xaa Ser Arg Arg His Pro Glu Xaa Ala Val Ser Val 
        355                 360                 365             


Leu Leu Arg Leu Ala Lys Glu Xaa Glu Ala Thr Leu Glu Glu Cys Cys 
    370                 375                 380                 


Ala Lys Asp Asp Pro His Ala Cys Xaa Ser Thr Val Phe Asp Lys Leu 
385                 390                 395                 400 


Lys His Leu Val Asp Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Asp 
                405                 410                 415     


Gln Phe Glu Lys Leu Gly Glu Xaa Gly Phe Gln Asn Ala Leu Ile Val 
            420                 425                 430         


Arg Xaa Thr Arg Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
        435                 440                 445             


Val Ser Arg Ser Leu Gly Lys Val Gly Thr Arg Cys Cys Thr Lys Pro 
    450                 455                 460                 


Glu Ser Glu Arg Met Pro Cys Thr Glu Asp Xaa Leu Ser Leu Ile Leu 
465                 470                 475                 480 


Asn Arg Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Glu Lys Val 
                485                 490                 495     


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
            500                 505                 510         


Ala Leu Thr Pro Asp Glu Thr Tyr Val Pro Lys Ala Phe Asp Glu Lys 
        515                 520                 525             


Leu Phe Thr Phe His Ala Asp Ile Cys Thr Leu Pro Asp Thr Glu Lys 
    530                 535                 540                 


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Leu Lys His Lys Pro 
545                 550                 555                 560 


Lys Ala Thr Glu Glu Gln Leu Lys Thr Val Met Glu Asn Phe Val Ala 
                565                 570                 575     


Phe Val Asp Lys Cys Cys Ala Ala Asp Asp Lys Glu Ala Cys Phe Ala 
            580                 585                 590         


Val Glu Gly Pro Lys Leu Val Val Ser Thr Gln Thr Ala Leu Ala 
        595                 600                 605         


<210>  12
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Val Lys Ser Gly Val 
1               5       


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Nitrosylation
<222>  (1)..(9)
<223>  Xaa correspond  un Tyr Nitrosyl

<400>  13

His Arg Gly Xaa Pro Gly Leu Asp Gly 
1               5                   


<210>  14
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Nitrosylation
<222>  (1)..(6)
<223>  Xaa correspond  un Tyr Nitrosyl

<400>  14

Leu Gln Xaa Met Arg Ala 
1               5       


