                         SEQUENCE LISTING

<110>  Genentech, Inc.
       WU, Herren
       SINGH, Sanjaya
       FUNG, Sek Chung
       AN, Ling-Ling
       LOWMAN, Henry B.
       KELLEY, Robert F.
       
 
<120>  Humanized Anti-Factor D Antibodies and Uses Thereof

<130>  P4028R1 WO

<150>  US  60/856,505
<151>  2006-11-02

<160>  58    

<170>  PatentIn version 3.4

<210>  1
<211>  115
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  VARIABLE HEAVY CHAIN DOMAIN OF MAB 166-32

<400>  1

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Glu Arg Glu Gly Gly Val Asp Asn Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  2
<211>  107
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  VARIABLE LIGHT CHAIN DOMAIN OF MAB 166-32

<400>  2

Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Ala Asp Phe Val Phe Thr Ile Asp Asn Met Leu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  345
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  VARIABLE HEAVY CHAIN DOMAIN OF MAB 166-32

<400>  3
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc     60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct    120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gacaacatat    180

gctgatgact tcaagggacg gtttgtcttc tctttggaaa cctctgccag cactgcctat    240

ttggagatca acaacctcaa aaatgaggac atggctacat atttctgtga aagagagggg    300

ggggttgaca actggggcca aggcaccact ctcacagtct cctca                    345


<210>  4
<211>  321
<212>  DNA
<213>  ARTIFICIAL

<220>
<223>  VARIABLE LIGHT CHAIN DOMAIN OF MAB 166-32

<400>  4
gaaacaactg tgacccagtc tcctgcatcc ctgtccatgg ctataggaga aaaagtcacc     60

atcagatgca taaccagcac tgatattgat gatgatatga actggtacca gcagaagcca    120

ggggaacctc ctaagctcct tatttcagga ggcaatactc ttcgtcctgg agtcccatcc    180

cgattctcca gcagtggcta tggtgcagat tttgttttta caattgacaa catgctctca    240

gaagatgttg cagattacta ctgtttgcaa agtgataact tgccgtacac gttcggaggg    300

gggaccaggc tggaaataaa a                                              321


<210>  5
<211>  107
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  VARIABLE LIGHT CHAIN DOMAIN OF HUMANIZED CLONE #56

<400>  5

Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Arg 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Asp Asn Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  115
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  VARIABLE HEAVY CHAIN DOMAIN OF HUMANIZED CLONE #56

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Glu Arg Glu Gly Gly Val Asp Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  7
<211>  107
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  VARIABLE LIGHT CHAIN DOMAIN OF HUMANIZED CLONE #111

<400>  7

Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Asp Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  8
<211>  115
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  VARIABLE HEAVY CHAIN DOMAIN OF HUMANIZED CLONE # 111

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Arg Glu Gly Gly Val Asn Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  9
<211>  107
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  VARIABLE LIGHT CHAIN DOMAIN OF HUMANIZED CLONE #250

<400>  9

Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser His Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Asp Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  10
<211>  115
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  VARIABLE HEAVY CHAIN DOMAIN OF HUMANIZED CLONE #250

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Arg Glu Gly Gly Val Asn Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  11
<211>  107
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  VARIABLE LIGHT CHAIN DOMAIN OF HUMANIZED CLONE #416

<400>  11

Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Asp Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Asp Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  12
<211>  115
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  VARIABLE HEAVY CHAIN DOMAIN OF HUMANIZED CLONE #416

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Arg Glu Gly Gly Val Asn Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  13
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-H1 OF MAB 166-32

<400>  13

Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   10  


<210>  14
<211>  19
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-H2 OF MAB 166-32

<400>  14

Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Asp 
1               5                   10                  15      


Asp Phe Lys 
            


<210>  15
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-H3 OF MAB 166-32

<400>  15

Glu Gly Gly Val Asp Asn 
1               5       


<210>  16
<211>  11
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-L1 OF MAB 166-32

<400>  16

Ile Thr Ser Thr Asp Ile Asp Asp Asp Met Asn 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-L2 OF MAB 166-32

<400>  17

Gly Gly Asn Thr Leu Arg Pro 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-L3 OF MAB 166-32

<400>  18

Leu Gln Ser Asp Asn Leu Pro Tyr Thr 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-L3 OF HUMANIZED CLONE #111

<400>  19

Leu Gln Ser Asp Ser Leu Pro Tyr Thr 
1               5                   


<210>  20
<211>  6
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-H3 OF HUMANIZED CLONE #111

<400>  20

Glu Gly Gly Val Asn Asn 
1               5       


<210>  21
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-L2 OF HUMANIZED CLONE #250

<400>  21

His Gly Asn Thr Leu Arg Pro 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-L3 OF HUMANIZED CLONE #250

<400>  22

Leu Gln Ser Asp Ser Leu Pro Tyr Thr 
1               5                   


<210>  23
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-H1 OF HUMANIZED CLONE #250

<400>  23

Gly Tyr Thr Phe Thr Asn Tyr Gly Leu Asn 
1               5                   10  


<210>  24
<211>  7
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-L2 OF HUMANIZED CLONE #416

<400>  24

Asp Gly Asn Thr Leu Arg Pro 
1               5           


<210>  25
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  CDR-H1 OF HUMANIZED CLONE #416

<400>  25

Gly Tyr Thr Phe Thr Ser Tyr Gly Met Asn 
1               5                   10  


<210>  26
<211>  107
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  VARIABLE LIGHT CHAIN COMPOSITE OF HUMANIZED CLONES


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

Asp Ile Gln Xaa Thr Gln Ser Pro Ser Ser Leu Ser Xaa Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Xaa Pro Lys Leu Leu Ile 
        35                  40                  45              


Xaa Asp Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Xaa 
    50                  55                  60                  


Ser Gly Ser Gly Xaa Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Asp Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  115
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  VARIABLE HEAVY CHAIN COMPOSITE OF HUMANIZED CLONES


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Gln Xaa Gln Leu Val Gln Ser Gly Xaa Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Xaa Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Xaa Arg Glu Gly Gly Val Asn Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  28
<211>  87
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Trp Val 
            20                  25                  30          


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Val Thr Ile 
        35                  40                  45              


Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
    50                  55                  60                  


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly 
65                  70                  75                  80  


Thr Leu Val Thr Val Ser Ser 
                85          


<210>  29
<211>  81
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp Thr Ser Thr 
        35                  40                  45              


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
65                  70                  75                  80  


Ser 
    


<210>  30
<211>  80
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp Thr Ser Thr 
        35                  40                  45              


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
65                  70                  75                  80  


<210>  31
<211>  79
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp Thr Ser Thr 
        35                  40                  45              


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
65                  70                  75                  


<210>  32
<211>  87
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Trp Ile 
            20                  25                  30          


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Arg Val Thr Ile 
        35                  40                  45              


Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
    50                  55                  60                  


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly 
65                  70                  75                  80  


Thr Leu Val Thr Val Ser Ser 
                85          


<210>  33
<211>  81
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
        35                  40                  45              


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
65                  70                  75                  80  


Ser 
    


<210>  34
<211>  80
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
        35                  40                  45              


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
65                  70                  75                  80  


<210>  35
<211>  79
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  35

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
        35                  40                  45              


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
65                  70                  75                  


<210>  36
<211>  87
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Val 
            20                  25                  30          


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Phe Thr Ile 
        35                  40                  45              


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    50                  55                  60                  


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly 
65                  70                  75                  80  


Thr Leu Val Thr Val Ser Ser 
                85          


<210>  37
<211>  81
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        35                  40                  45              


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
65                  70                  75                  80  


Ser 
    


<210>  38
<211>  80
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        35                  40                  45              


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
65                  70                  75                  80  


<210>  39
<211>  79
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        35                  40                  45              


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
65                  70                  75                  


<210>  40
<211>  87
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Trp Val 
            20                  25                  30          


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Phe Thr Ile 
        35                  40                  45              


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
    50                  55                  60                  


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gln Gly 
65                  70                  75                  80  


Thr Leu Val Thr Val Ser Ser 
                85          


<210>  41
<211>  81
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
        35                  40                  45              


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Ser Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
65                  70                  75                  80  


Ser 
    


<210>  42
<211>  80
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
        35                  40                  45              


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
65                  70                  75                  80  


<210>  43
<211>  87
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Trp Val 
            20                  25                  30          


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Phe Thr Ile 
        35                  40                  45              


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
    50                  55                  60                  


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly 
65                  70                  75                  80  


Thr Leu Val Thr Val Ser Ser 
                85          


<210>  44
<211>  81
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
        35                  40                  45              


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
65                  70                  75                  80  


Ser 
    


<210>  45
<211>  80
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
        35                  40                  45              


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
65                  70                  75                  80  


<210>  46
<211>  79
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
        35                  40                  45              


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
65                  70                  75                  


<210>  47
<211>  80
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            20                  25                  30          


Pro Lys Leu Leu Ile Tyr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        35                  40                  45              


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    50                  55                  60                  


Phe Ala Thr Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
65                  70                  75                  80  


<210>  48
<211>  80
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
            20                  25                  30          


Pro Gln Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        35                  40                  45              


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
    50                  55                  60                  


Val Gly Val Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
65                  70                  75                  80  


<210>  49
<211>  80
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  49

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
            20                  25                  30          


Pro Arg Leu Leu Ile Tyr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
        35                  40                  45              


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp 
    50                  55                  60                  


Phe Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
65                  70                  75                  80  


<210>  50
<211>  80
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
            20                  25                  30          


Pro Lys Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        35                  40                  45              


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
    50                  55                  60                  


Val Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
65                  70                  75                  80  


<210>  51
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  51

Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
            20                  25                  30      


<210>  52
<211>  32
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  52

Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
            20                  25                  30          


<210>  53
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  53

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  54
<211>  10
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid


<400>  54

Phe Gly Gln Gly Thr Lys Xaa Glu Ile Lys 
1               5                   10  


<210>  55
<211>  87
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Trp Val 
            20                  25                  30          


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Phe Val Phe 
        35                  40                  45              


Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu 
    50                  55                  60                  


Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly 
65                  70                  75                  80  


Thr Ser Leu Thr Val Ser Ser 
                85          


<210>  56
<211>  81
<212>  PRT
<213>  artificial

<220>
<223>  Sequence is synthesized

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Gln Gly Leu Glu Trp Met Arg Phe Val Phe Ser Leu Asp Thr Ser Val 
        35                  40                  45              


Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr Ser Leu Thr Val Ser 
65                  70                  75                  80  


Ser 
    


<210>  57
<211>  80
<212>  PRT
<213>  artificial

<220>
<223>  Sequence is synthesized

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Gln Gly Leu Glu Trp Met Arg Phe Val Phe Ser Leu Asp Thr Ser Val 
        35                  40                  45              


Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser 
65                  70                  75                  80  


<210>  58
<211>  79
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Sequence is synthesized

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Gln Gly Leu Glu Trp Met Arg Phe Val Phe Ser Leu Asp Thr Ser Val 
        35                  40                  45              


Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala 
    50                  55                  60                  


Val Tyr Tyr Cys Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser 
65                  70                  75                  


