                         SEQUENCE LISTING

<110>  Lpath, Inc.
       Sabbadini, Roger A.
       Garland, William A.
       Stoller, Glenn
 
<120>  COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES AND CONDITIONS

<130>  LPT-3010-UT

<150>  60/854,971
<151>  2006-10-27

<160>  37    

<170>  PatentIn version 3.4

<210>  1
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  1
atggratgga gckggrtctt tmtctt                                          26


<210>  2
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  2
cagtggatag acagatgggg g                                               21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  3
cagtggatag accgatgggg c                                               21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  4
cagtggatag actgatgggg g                                               21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  5
caagggatag acagatgggg c                                               21


<210>  6
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  6
gtctctgatt ctagggca                                                   18


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  7
actggatggt gggaagatgg                                                 20


<210>  8
<211>  120
<212>  PRT
<213>  Mus sp.

<400>  8

Gln Ala His Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ile Phe Ile Asp His 
            20                  25                  30          


Thr Ile His Trp Met Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Ser Pro Arg His Asp Ile Thr Lys Tyr Asn Glu Met Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Val Asn Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Tyr Gly Ser Thr Ile Trp Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser 
        115                 120 


<210>  9
<211>  107
<212>  PRT
<213>  Mus sp.

<400>  9

Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Ile Thr Thr Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Phe Gln Gln Lys Pro Gly Glu Pro Pro Asn Leu Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Ile Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Leu Phe Thr Ile Glu Asn Met Leu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  10
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  10

Ile Thr Thr Thr Asp Ile Asp Asp Asp Met Asn 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  11

Glu Gly Asn Ile Leu Arg Pro 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  12

Leu Gln Ser Asp Asn Leu Pro Phe Thr 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  13

Asp His Thr Ile His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  14

Cys Ile Ser Pro Arg His Asp Ile Thr Lys Tyr Asn Glu Met Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  12
<212>  PRT
<213>  Mus sp.

<400>  15

Gly Gly Phe Tyr Gly Ser Thr Ile Trp Phe Asp Phe 
1               5                   10          


<210>  16
<211>  147
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized murine antibody variable domains

<400>  16

Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Cys Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Gln Ser Phe Gly Tyr Ile Phe 
        35                  40                  45              


Ile Asp His Thr Ile His Trp Val Arg Gln Met Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Cys Ile Ser Pro Arg His Asp Ile Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Met Phe Arg Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Gly Phe Tyr Gly Ser Thr Ile Trp Phe Asp 
        115                 120                 125             


Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser 
145         


<210>  17
<211>  134
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized murine antibody variable domains

<400>  17

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Glu Thr Thr Leu Thr Gln Ser Pro Ser Phe 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ile Thr Thr 
        35                  40                  45              


Thr Asp Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Glu Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Glu Gly Asn Ile Leu Arg Pro Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Lys Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Ser Asp Asn Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Glu Trp Ile Pro 
    130                 


<210>  18
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb CDR nucleotide sequence

<400>  18
ataaccacca ctgatattga tgatgatatg aac                                  33


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb CDR nucleotide sequence

<400>  19
gaaggcaata ttcttcgtcc t                                               21


<210>  20
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb CDR nucleotide sequence

<400>  20
ttgcagagtg ataacttacc attcacg                                         27


<210>  21
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb CDR nucleotide sequence

<400>  21
gaccatactt cac                                                        13


<210>  22
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb CDR nucleotide sequence

<400>  22
tgtatttctc ccagacatga tattactaaa tacaatgaga tgttcagggg c              51


<210>  23
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb CDR nucleotide sequence

<400>  23
ggggggttct acggtagtac tatctggttt gacttt                               36


<210>  24
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb CDR nucleotide sequence

<400>  24
ggggggttct acggtagtac tatctggttt gacttt                               36


<210>  25
<211>  455
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb nucleotide sequence

<400>  25
cgccaagctt gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct     60

ccaaggagtc tgttccgagg tgcagctggt gcagtctgga gcagaggtga aaaagcccgg    120

ggagtctctg aagatctcct gtcagagttt tggatacatc tttatcgacc atacttcact    180

gggtgcgcca gatgcccggg caaggcctgg agtggatgtg tatttctccc agacatgata    240

ttactaaata caatgagatg ttcaggggcc aggtcaccat ctcagccgac aagtccagca    300

gcaccgccta cttgcagtgg agcagcctga aggcctcgga caccgccatg tatttctgtg    360

cgagaggggg gttctacggt agtactatct ggtttgactt ttggggccaa gggacaatgg    420

tcaccgtctc ttcagcctcc accaagggcc catcg                               455


<210>  26
<211>  452
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb nucleotide sequence

<400>  26
cgccaagctt gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct     60

ccaaggagtc tgttccgagg tgcagctggt gcagtctgga gcagaggtga aaaagcccgg    120

ggagtctctg aagatctcct gtcagagttt tggatacatc gaccatactt cactggatgc    180

gccagatgcc cgggcaaggc ctggagtgga tgggggctat ttctcccaga catgatatta    240

ctaaatacaa tgagatgttc aggggccagg tcaccatctc agccgacaag tccagcagca    300

ccgcctactt gcagtggagc agcctgaagg cctcggacac cgccatgtat ttctgtgcga    360

gaggggggtt ctacggtagt actatctggt ttgacttttg gggccaaggg acaatggtca    420

ccgtctcttc agcctccacc aagggcccat cg                                  452


<210>  27
<211>  147
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized murine mAb sequence

<400>  27

Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Cys Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Gln Ser Phe Gly Tyr Ile Phe 
        35                  40                  45              


Ile Asp His Thr Ile His Trp Met Arg Gln Met Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Ala Ile Ser Pro Arg His Asp Ile Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Met Phe Arg Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Gly Phe Tyr Gly Ser Thr Ile Trp Phe Asp 
        115                 120                 125             


Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser 
145         


<210>  28
<211>  419
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb sequence

<400>  28
cgccaagctt gccgccacca tggacatgag ggtccccgct cagctcctgg ggctcctgct     60

gctctggctc ccaggtgcca gatgtgaaac gacactcacg cagtctccat ccttcctgtc    120

tgcatctgta ggagacagag tcaccatcac ataaccacca ctgatattga tgatgatatg    180

aactggtatc agcaggaacc agggaaagcc cctaagctcc tgatctatga aggcaatatt    240

cttcgtcctg gggtcccatc aaggttcagc ggcagtggat ctggcacaga tttcactctc    300

accatcagca aattgcagcc tgaagatttt gcaacttatt actgtttgca gagtgataac    360

ttaccattca cgttcggcca agggaccaag ctggagatca aacgtgagtg gatcccgcg     419


<210>  29
<211>  407
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb sequence

<400>  29
cgccaagctt gccgccacca tggacatgag ggtccccgct cagctcctgg ggctcctgct     60

gctctggctc ccaggggcca gatgtgaaac gacagtgacg cagtctccat ccttcctgtc    120

tgcatctgta ggagacagag tcaccatcac ttgcataacc accactgata ttgatgatga    180

tatgaactgg ttccagcagg aaccagggaa agcccctaag ctcctgatct ccgaaggcaa    240

tattcttcgt cctggggtcc catcaagatt cagcagcagt ggatatggca cagatttcac    300

tctcaccatc agcaaattgc agcctgaaga ttttgcaact tattactgtt tgcagagtga    360

taacttacca ttcactttcg gccaagggac caagctggag atcaaac                  407


<210>  30
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized murine mAb sequence

<400>  30

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Glu Thr Thr Val Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ile Thr Thr Thr Asp 
        35                  40                  45              


Ile Asp Asp Asp Met Asn Trp Phe Gln Glu Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Ser Glu Gly Asn Ile Leu Arg Pro Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Ser Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Lys 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Asp Asn 
            100                 105                 110         


Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  31
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized murine mAb sequence

<400>  31

Ala Ile Ser Pro Arg His Asp Ile Thr Lys Tyr Asn Glu Met Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  140
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized murine mAb sequence

<400>  32

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Gln Ser Phe Gly Tyr Ile Phe 
        35                  40                  45              


Ile Asp His Thr Ile His Trp Met Arg Gln Met Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Ala Ile Ser Pro Arg His Asp Ile Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Met Phe Arg Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Gly Phe Tyr Gly Ser Thr Ile Trp Phe Asp 
        115                 120                 125             


Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140 


<210>  33
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized murine mAb sequence

<400>  33

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Glu Thr Thr Val Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ile Thr Thr Thr Asp 
        35                  40                  45              


Ile Asp Asp Asp Met Asn Trp Phe Gln Gln Glu Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Glu Gly Asn Ile Leu Arg Pro Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Ser Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Lys Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Asp 
            100                 105                 110         


Asn Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  34
<211>  2034
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb sequence

<400>  34
aagcttgccg ccaccatgga atggagctgg gtgttcctgt tctttctgtc cgtgaccaca     60

ggcgtgcatt ctgaggtgca gctggtgcag tctggagcag aggtgaaaaa gcccggggag    120

tctctgaaga tctcctgtca gagttttgga tacatcttta tcgaccatac tattcactgg    180

atgcgccaga tgcccgggca aggcctggag tggatggggg ctatttctcc cagacatgat    240

attactaaat acaatgagat gttcaggggc caggtcacca tctcagccga caagtccagc    300

agcaccgcct acttgcagtg gagcagcctg aaggcctcgg acaccgccat gtatttctgt    360

gcgagagggg ggttctacgg tagtactatc tggtttgact tttggggcca agggacaatg    420

gtcaccgtct cttcagcctc caccaagggc ccatcggtct tccccctggc accctcctcc    480

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa    540

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct    600

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc    660

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac    720

aagagagttg gtgagaggcc agcacaggga gggagggtgt ctgctggaag ccaggctcag    780

cgctcctgcc tggacgcatc ccggctatgc agtcccagtc cagggcagca aggcaggccc    840

cgtctgcctc ttcacccgga ggcctctgcc cgccccactc atgctcaggg agagggtctt    900

ctggcttttt ccccaggctc tgggcaggca caggctaggt gcccctaacc caggccctgc    960

acacaaaggg gcaggtgctg ggctcagacc tgccaagagc catatccggg aggaccctgc   1020

ccctgaccta agcccacccc aaaggccaaa ctctccactc cctcagctcg gacaccttct   1080

ctcctcccag attccagtaa ctcccaatct tctctctgca gagcccaaat cttgtgacaa   1140

aactcacaca tgcccaccgt gcccaggtaa gccagcccag gcctcgccct ccagctcaag   1200

gcgggacagg tgccctagag tagcctgcat ccagggacag gccccagccg ggtgctgaca   1260

cgtccacctc catctcttcc tcagcacctg aactcctggg gggaccgtca gtcttcctct   1320

tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg   1380

tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg   1440

aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg   1500

tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg   1560

tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc aaaggtggga   1620

cccgtggggt gcgagggcca catggacaga ggccggctcg gcccaccctc tgccctgaga   1680

gtgaccgctg taccaacctc tgtccctaca gggcagcccc gagaaccaca ggtgtacacc   1740

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa   1800

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac   1860

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc   1920

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag   1980

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atag         2034


<210>  35
<211>  455
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized murine mAb sequence

<400>  35

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Gln Ser Phe Gly Tyr Ile Phe 
        35                  40                  45              


Ile Asp His Thr Ile His Trp Met Arg Gln Met Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Ala Ile Ser Pro Arg His Asp Ile Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Met Phe Arg Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Gly Phe Tyr Gly Ser Thr Ile Trp Phe Asp 
        115                 120                 125             


Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  36
<211>  720
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized murine mAb sequence

<400>  36
aagcttgccg ccaccatgtc tgtgcctacc caggtgctgg gactgctgct gctgtggctg     60

acagacgccc gctgtgaaac gacagtgacg cagtctccat ccttcctgtc tgcatctgta    120

ggagacagag tcaccatcac ttgcataacc accactgata ttgatgatga tatgaactgg    180

ttccagcagg aaccagggaa agcccctaag ctcctgatct ccgaaggcaa tattcttcgt    240

cctggggtcc catcaagatt cagcagcagt ggatatggca cagatttcac tctcaccatc    300

agcaaattgc agcctgaaga ttttgcaact tattactgtt tgcagagtga taacttacca    360

ttcactttcg gccaagggac caagctggag atcaaacgta cggtggctgc accatctgtc    420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg    480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa    540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc    600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa    660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag    720


<210>  37
<211>  234
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized murine mAb sequence

<400>  37

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Glu Thr Thr Val Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ile Thr Thr Thr Asp 
        35                  40                  45              


Ile Asp Asp Asp Met Asn Trp Phe Gln Gln Glu Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Glu Gly Asn Ile Leu Arg Pro Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Ser Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Lys Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Asp 
            100                 105                 110         


Asn Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


