SEQUENCE LISTING

<110>  MAO, LI
       REN, HENING
       ZHANG, JUN
 
<120>  ANTI-HYPERPROLIFERATIVE THERAPIES TARGETING HDGF

<130>  UTFC:955WO

<140>  UNKNOWN
<141>  2006-12-15

<150>  60/810,062
<151>  2002-05-31

<150>  60/753,600
<151>  2005-12-23

<160>  48    

<170>  PatentIn version 3.3

<210>  1
<211>  2376
<212>  DNA
<213>  Homo sapiens

<400>  1
gaggaggagt ggggaccggg cggggggtgg aggaagaggc ctcgcgcaga ggagggagca     60

attgaatttc aaacacaaac aactcgacga gcgcgcaccc accgcgccgg agccttgccc    120

cgatccgcgc ccgccccgtc cgtgcggcgc gcgggcggag acgccgtggc cgcgccggag    180

ctcgggccgg gggccaccat cgaggcgggg gccgcgcgag ggccggagcg gagcggcgcc    240

gccaccgccg cacgcgcaaa cttgggctcg cgcttcccgg cccggcgcgg agcccggggc    300

gcccggagcc ccgccatgtc gcgatccaac cggcagaagg agtacaaatg cggggacctg    360

gtgttcgcca agatgaaggg ctacccacac tggccggccc ggattgacga gatgcctgag    420

gctgccgtga aatcaacagc caacaaatac caagtctttt ttttcgggac ccacgagacg    480

gcattcctgg gccccaaaga cctcttccct tacgaggaat ccaaggagaa gtttggcaag    540

cccaacaaga ggaaagggtt cagcgagggg ctgtgggaga tcgagaacaa ccctactgtc    600

aaggcttccg gctatcagtc ctcccagaaa aagagctgtg tggaagagcc tgaaccagag    660

cccgaagctg cagagggtga cggtgataag aaggggaatg cagagggcag cagcgacgag    720

gaagggaagc tggtcattga tgagccagcc aaggagaaga acgagaaagg agcgttgaag    780

aggagagcag gggacttgct ggaggactct cctaaacgtc ccaaggaggc agaaaaccct    840

gaaggagagg agaaggaggc agccaccttg gaggttgaga ggccccttcc tatggaggtg    900

gaaaagaata gcaccccctc tgagcccggc tctggccggg ggcctcccca agaggaagaa    960

gaagaggagg atgaagagga agaggctacc aaggaagatg ctgaggcccc aggcatcaga   1020

gatcatgaga gcctgtagcc accaatgttt caagaggagc ccccaccctg ttcctgctgc   1080

tgtctgggtg ctactgggga aactggccat ggcctgcaaa ctgggaaccc ctttcccacc   1140

ccaacctgct ctcctcttct actcactttt cccactccaa gcccagccca tggagattga   1200

cctggatggg gcaggccacc tggctctcac ctctaggtcc ccatactcct atgatctgag   1260

tcagagccat gtcttctccc tggaatgagt tgaggccact gtgttccttc cgcttggagc   1320

tattttccag gcttctgctg gggcctggga caactgctcc cacctcctga cacccttctc   1380

ccactctcct aggcattctg gacctctggg ttgggatcag gggtaggaat ggaaggatgg   1440

agcatcaaca gcagggtggg cttgtggggc ctgggagggg caatcctcaa atgcggggtg   1500

ggggcagcac aggagggcgg cctccttctg agctcctgtc ccctgctaca cctattatcc   1560

cagctgccta gattcaggga aagtgggaca gcttgtaggg gaggggctcc tttccataaa   1620

tccttgatga ttgacaacac ccatttttcc ttttgccgac cccaagagtt ttgggagttg   1680

tagttaatca tcaagagaat ttggggcttc caagttgttc gggccaagga cctgagacct   1740

gaagggttga ctttacccat ttgggtggga gtgttgagca tctgtccccc tttagatctc   1800

tgaagccaca aataggatgc ttgggaagac tcctagctgt cctttttcct ctccacacag   1860

tgctcaaggc cagcttatag tcatatatat cacccagaca taaaggaaaa gacacatttt   1920

ttaggaaatg tttttaataa aagaaaatta caaaaaaaaa ttttaaagac ccctaaccct   1980

ttgtgtgctc tccattctgc tccttcccca tcgttgcccc catttctgag gtgcactggg   2040

aggctcccct tctatttggg gcttgatgac tttctttttg tagctggggc tttgatgttc   2100

cttccagtgt catttctcat ccacataccc tgacctggcc ccctcagtgt tgtcaccaga   2160

tctgatttgt aacccactga gaggacagag agaaataagt gccctctccc accctcttcc   2220

tactggtctc tctatgcctc tctacagtct cgtctctttt accctggccc ctctcccttg   2280

ggctctgatg aaaaattgct gactgtagct ttggaagttt agctctgaga accgtagatg   2340

atttcagttc taggaaaata aaacccgttg attact                             2376


<210>  2
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Arg Ser Asn Arg Gln Lys Glu Tyr Lys Cys Gly Asp Leu Val 
1               5                   10                  15      


Phe Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu 
            20                  25                  30          


Met Pro Glu Ala Ala Val Lys Ser Thr Ala Asn Lys Tyr Gln Val Phe 
        35                  40                  45              


Phe Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe 
    50                  55                  60                  


Pro Tyr Glu Glu Ser Lys Glu Lys Phe Gly Lys Pro Asn Lys Arg Lys 
65                  70                  75                  80  


Gly Phe Ser Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Thr Val Lys 
                85                  90                  95      


Ala Ser Gly Tyr Gln Ser Ser Gln Lys Lys Ser Cys Val Glu Glu Pro 
            100                 105                 110         


Glu Pro Glu Pro Glu Ala Ala Glu Gly Asp Gly Asp Lys Lys Gly Asn 
        115                 120                 125             


Ala Glu Gly Ser Ser Asp Glu Glu Gly Lys Leu Val Ile Asp Glu Pro 
    130                 135                 140                 


Ala Lys Glu Lys Asn Glu Lys Gly Ala Leu Lys Arg Arg Ala Gly Asp 
145                 150                 155                 160 


Leu Leu Glu Asp Ser Pro Lys Arg Pro Lys Glu Ala Glu Asn Pro Glu 
                165                 170                 175     


Gly Glu Glu Lys Glu Ala Ala Thr Leu Glu Val Glu Arg Pro Leu Pro 
            180                 185                 190         


Met Glu Val Glu Lys Asn Ser Thr Pro Ser Glu Pro Gly Ser Gly Arg 
        195                 200                 205             


Gly Pro Pro Gln Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Ala 
    210                 215                 220                 


Thr Lys Glu Asp Ala Glu Ala Pro Gly Ile Arg Asp His Glu Ser Leu 
225                 230                 235                 240 


<210>  3
<211>  304
<212>  PRT
<213>  Pan troglodytes

<400>  3

Met Ser Arg Ser Asn Arg Gln Lys Glu Tyr Lys Cys Gly Asp Leu Val 
1               5                   10                  15      


Phe Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu 
            20                  25                  30          


Met Pro Glu Ala Ala Val Lys Ser Thr Ala Asn Lys Tyr Gln Val Phe 
        35                  40                  45              


Phe Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe 
    50                  55                  60                  


Pro Tyr Glu Glu Ser Lys Glu Lys Phe Gly Lys Pro Asn Lys Arg Lys 
65                  70                  75                  80  


Gly Phe Ser Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Thr Val Lys 
                85                  90                  95      


Ala Ser Gly Tyr Gln Ser Ser Gln Lys Lys Ser Cys Val Glu Glu Pro 
            100                 105                 110         


Glu Pro Glu Pro Glu Ala Ala Glu Gly Asp Gly Asp Lys Lys Gly Asn 
        115                 120                 125             


Ala Glu Gly Ser Ser Asp Glu Glu Gly Lys Leu Val Ile Asp Glu Pro 
    130                 135                 140                 


Ala Lys Glu Lys Asn Glu Lys Gly Ala Leu Lys Arg Arg Ala Gly Asp 
145                 150                 155                 160 


Leu Leu Glu Asp Ser Pro Lys Arg Pro Lys Glu Ala Glu Asn Pro Glu 
                165                 170                 175     


Gly Glu Glu Lys Glu Ala Ala Gln Glu Gly Ser Leu Leu Leu Ser Ser 
            180                 185                 190         


Cys Pro Leu Leu His Leu Leu Ser Gln Leu Pro Arg Phe Arg Glu Ser 
        195                 200                 205             


Gly Thr Ala Cys Arg Gly Gly Ala Pro Phe His Lys Ser Leu Met Ile 
    210                 215                 220                 


Asp Asn Thr His Phe Ser Phe Cys Arg Pro Gln Glu Lys Ser Thr Gly 
225                 230                 235                 240 


Val Ala Gly Glu Gly Thr Leu Arg Ala His Val Leu Ile Ile Arg Ser 
                245                 250                 255     


Ala Ala Glu Ser Gly Glu His Ala Gly Lys Thr Pro Leu Arg Asp Ala 
            260                 265                 270         


His Gln Gln His Leu Gln Ile Val Glu Gly Lys Lys Gly Arg Ile Ser 
        275                 280                 285             


Gly Ala Cys Lys Leu Leu Trp Ala Gly Val Val Gln Thr Trp Ile Asp 
    290                 295                 300                 


<210>  4
<211>  230
<212>  PRT
<213>  Canis familiaris

<400>  4

Met Gly Arg Ala Gln Leu Val Leu Gly Leu Pro Gly Gly Arg Gly Arg 
1               5                   10                  15      


Thr Ser Ile Asp Glu Met Pro Glu Ala Ala Val Lys Ser Thr Ala Asn 
            20                  25                  30          


Lys Tyr Gln Val Phe Phe Phe Gly Thr His Glu Thr Ala Phe Leu Gly 
        35                  40                  45              


Pro Lys Asp Leu Phe Pro Tyr Glu Glu Ser Lys Glu Lys Phe Gly Lys 
    50                  55                  60                  


Pro Asn Lys Arg Lys Gly Phe Ser Glu Gly Leu Trp Glu Ile Glu Asn 
65                  70                  75                  80  


Asn Pro Thr Val Lys Ala Ser Gly Tyr Gln Ser Thr Pro Lys Lys Ser 
                85                  90                  95      


Ser Gly Asp Glu Pro Glu Pro Glu Pro Glu Ala Ala Glu Gly Asp Gly 
            100                 105                 110         


Asp Lys Lys Gly Asn Ala Glu Gly Ser Ser Asp Glu Glu Gly Lys Leu 
        115                 120                 125             


Val Ile Asp Glu Pro Ala Lys Glu Lys Asn Glu Lys Gly Ala Leu Lys 
    130                 135                 140                 


Arg Arg Ala Gly Glu Leu Leu Glu Asp Ser Pro Lys Arg Pro Lys Glu 
145                 150                 155                 160 


Ala Glu Asp Pro Glu Glu Glu Glu Lys Glu Val Ala Ser Leu Glu Gly 
                165                 170                 175     


Glu Arg Pro Leu Pro Val Glu Val Glu Lys Asn Ser Thr Pro Ser Glu 
            180                 185                 190         


Pro Ser Ser Gly Arg Gly Pro Pro Gln Glu Glu Glu Glu Glu Glu Glu 
        195                 200                 205             


Glu Glu Glu Glu Glu Ala Ala Lys Glu Asp Ala Glu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Asp His Glu Ser Leu 
225                 230 


<210>  5
<211>  237
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ser Arg Ser Asn Arg Gln Lys Glu Tyr Lys Cys Gly Asp Leu Val 
1               5                   10                  15      


Phe Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu 
            20                  25                  30          


Met Pro Glu Ala Ala Val Lys Ser Thr Ala Asn Lys Tyr Gln Val Phe 
        35                  40                  45              


Phe Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe 
    50                  55                  60                  


Pro Tyr Glu Glu Ser Lys Glu Lys Phe Gly Lys Pro Asn Lys Arg Lys 
65                  70                  75                  80  


Gly Phe Ser Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Thr Val Lys 
                85                  90                  95      


Ala Ser Gly Tyr Gln Ser Ser Gln Lys Lys Ser Cys Ala Ala Glu Pro 
            100                 105                 110         


Glu Val Glu Pro Glu Asp His Glu Gly Asp Gly Asp Lys Lys Gly Ser 
        115                 120                 125             


Ala Glu Gly Ser Ser Asp Glu Glu Gly Lys Leu Val Ile Asp Glu Pro 
    130                 135                 140                 


Ala Lys Glu Lys Asn Glu Lys Gly Thr Leu Lys Arg Arg Ala Gly Asp 
145                 150                 155                 160 


Val Leu Glu Asp Ser Pro Lys Arg Pro Lys Glu Ser Gly Asp His Glu 
                165                 170                 175     


Glu Glu Asp Lys Glu Ile Ala Ala Leu Glu Gly Glu Arg Pro Leu Pro 
            180                 185                 190         


Val Glu Val Glu Lys Asn Ser Thr Pro Ser Glu Pro Asp Ser Gly Gln 
        195                 200                 205             


Gly Pro Pro Ala Glu Glu Glu Glu Gly Glu Glu Glu Ala Ala Lys Glu 
    210                 215                 220                 


Glu Ala Glu Ala Gln Gly Val Arg Asp His Glu Ser Leu 
225                 230                 235         


<210>  6
<211>  237
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Ser Arg Ser Asn Arg Gln Lys Glu Tyr Lys Cys Gly Asp Leu Val 
1               5                   10                  15      


Phe Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu 
            20                  25                  30          


Met Pro Glu Ala Ala Val Lys Ser Thr Ala Asn Lys Tyr Gln Val Phe 
        35                  40                  45              


Phe Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe 
    50                  55                  60                  


Pro Tyr Glu Glu Ser Lys Glu Lys Phe Gly Lys Pro Asn Lys Arg Lys 
65                  70                  75                  80  


Gly Phe Ser Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Thr Val Lys 
                85                  90                  95      


Ala Ser Gly Tyr Gln Ser Ser Gln Lys Lys Ser Cys Ala Glu Glu Pro 
            100                 105                 110         


Glu Val Glu Pro Glu Ala His Glu Gly Asp Gly Asp Lys Lys Gly Asn 
        115                 120                 125             


Ala Glu Gly Ser Ser Asp Glu Glu Gly Lys Leu Val Ile Asp Glu Pro 
    130                 135                 140                 


Ala Lys Glu Lys Asn Glu Lys Gly Met Leu Lys Arg Arg Ala Gly Asp 
145                 150                 155                 160 


Met Leu Glu Asp Ser Pro Lys Arg Pro Lys Glu Ser Gly Asp His Glu 
                165                 170                 175     


Glu Glu Glu Lys Glu Ile Ala Ala Leu Glu Gly Glu Arg Pro Leu Pro 
            180                 185                 190         


Val Glu Met Glu Lys Asn Ser Thr Pro Ser Glu Pro Asp Ser Gly Gln 
        195                 200                 205             


Gly Pro Pro Pro Glu Glu Glu Glu Gly Glu Glu Glu Ala Ala Lys Glu 
    210                 215                 220                 


Glu Ala Glu Ala Gln Gly Val Arg Asp His Glu Ser Leu 
225                 230                 235         


<210>  7
<211>  239
<212>  PRT
<213>  Bos taurus

<400>  7

Met Ser Arg Ser Asn Arg Gln Lys Glu Tyr Lys Cys Gly Asp Leu Val 
1               5                   10                  15      


Phe Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu 
            20                  25                  30          


Met Pro Glu Ala Ala Val Lys Ser Thr Ala Asn Lys Tyr Gln Val Phe 
        35                  40                  45              


Phe Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe 
    50                  55                  60                  


Pro Tyr Glu Glu Ser Lys Glu Lys Phe Gly Lys Pro Asn Lys Arg Lys 
65                  70                  75                  80  


Gly Phe Ser Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Thr Val Lys 
                85                  90                  95      


Ala Ser Gly Tyr Gln Ser Ser Gln Lys Lys Ser Cys Val Glu Glu Pro 
            100                 105                 110         


Glu Pro Glu Pro Glu Ala Thr Glu Gly Asp Gly Asp Lys Lys Gly Asn 
        115                 120                 125             


Ala Glu Gly Ser Ser Asp Glu Glu Gly Lys Leu Val Ile Asp Glu Pro 
    130                 135                 140                 


Thr Lys Glu Lys Asn Glu Lys Gly Ala Leu Lys Arg Arg Ala Gly Asp 
145                 150                 155                 160 


Leu Leu Glu Asp Ser Pro Lys Arg Pro Lys Glu Ala Glu Asp Leu Glu 
                165                 170                 175     


Gly Glu Glu Lys Glu Gly Ala Thr Leu Glu Gly Glu Arg Pro Leu Pro 
            180                 185                 190         


Val Glu Ala Glu Lys Asn Ser Thr Pro Ser Glu Pro Gly Ser Gly Arg 
        195                 200                 205             


Gly Pro Pro Gln Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Ala 
    210                 215                 220                 


Lys Glu Asp Ala Glu Ala Pro Gly Leu Arg Asp His Glu Ser Leu 
225                 230                 235                 


<210>  8
<211>  1333
<212>  DNA
<213>  Mus musculus

<400>  8
ggccaaggag ggggcgccca gagcacacgc tatgtcttgc ttcagccgct ctaagtacaa     60

gaccggggac ctggtgtttg ccaagttaaa gggctatgcc cactggccag cgaggatcga    120

acatgtcgct gaagccaacc gctaccaggt gttcttcttc gggacccatg agaccgccct    180

gctgggtccc aggcacctgt tcccttatga ggagtccaaa gagaagttcg gcaagcccaa    240

caagaggcgc ggcttcagcg aggggctgtg ggagatcgag cacgacccta tggttgaggc    300

ctcctctagc ctgtgctcag aagaggatca gagctacaca gaggatcctg ggctagcaga    360

ggagccggaa ctaggacagg agctggtgca ggagctggag cccgaattca tgcctgagct    420

ggaggcagaa cctgagatgc ctgagaccga gtgtgaacag gagcccgagc cccagcctgc    480

ctatgacctg ctggacgccg tggaggagcc gggcctcacc aaggccgagc caggagatca    540

gcaagccgag catgtgcaag agaagcaccc tgaggtggag gcagaggctg aggctgaggc    600

tgaggccgag gcagaggcgg aggcggaggc caaggctgag gtggaggagc cggggagtct    660

gaagaggagc gcggaggatg aagagcctca ttgtcctctc aaacggccca gggaggcggc    720

tcctggtgcg ttggagatgg agcctgctga agagcgcgag gctgaggcct cccccttcgt    780

ggaggagcct gaccaagccc aggagcagct gcctccgttg gaggaagagg ccacagaaaa    840

ggcggtccag ggcctgattg ttggagaaat agaaggcctg tagtcacggt gtttgtagaa    900

gagccccttt tacccgttcc tgctgccacc tggctgtggc ttgggaaacc cactagggcc    960

cagtcttcaa cccagtccac ctctccttca ttcattcgcc ttctacaagc ctaaattcct   1020

ggcatgaggg gacaggccag ttgacatcaa ctttgtggct taagtagtga ccacccttcc   1080

caccctaaac tcttaggggc attttggacc tctgcctagg aaccaggagt gaagagggat   1140

ggaagatgaa gagcagggac aacattcaaa ggtctggaag gaacagtctg taaactatgg   1200

cgatgctagt ctactccaca cccaccctga gtgccgccca taattccttt cagagtactg   1260

taggttcggg gaaagtgaga cagcagtgtc cagtaaagat ttttgttgtc ccagtcactt   1320

tctttctttc ccg                                                      1333


<210>  9
<211>  283
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ser Cys Phe Ser Arg Ser Lys Tyr Lys Thr Gly Asp Leu Val Phe 
1               5                   10                  15      


Ala Lys Leu Lys Gly Tyr Ala His Trp Pro Ala Arg Ile Glu His Val 
            20                  25                  30          


Ala Glu Ala Asn Arg Tyr Gln Val Phe Phe Phe Gly Thr His Glu Thr 
        35                  40                  45              


Ala Leu Leu Gly Pro Arg His Leu Phe Pro Tyr Glu Glu Ser Lys Glu 
    50                  55                  60                  


Lys Phe Gly Lys Pro Asn Lys Arg Arg Gly Phe Ser Glu Gly Leu Trp 
65                  70                  75                  80  


Glu Ile Glu His Asp Pro Met Val Glu Ala Ser Ser Ser Leu Cys Ser 
                85                  90                  95      


Glu Glu Asp Gln Ser Tyr Thr Glu Asp Pro Gly Leu Ala Glu Glu Pro 
            100                 105                 110         


Glu Leu Gly Gln Glu Leu Val Gln Glu Leu Glu Pro Glu Phe Met Pro 
        115                 120                 125             


Glu Leu Glu Ala Glu Pro Glu Met Pro Glu Thr Glu Cys Glu Gln Glu 
    130                 135                 140                 


Pro Glu Pro Gln Pro Ala Tyr Asp Leu Leu Asp Ala Val Glu Glu Pro 
145                 150                 155                 160 


Gly Leu Thr Lys Ala Glu Pro Gly Asp Gln Gln Ala Glu His Val Gln 
                165                 170                 175     


Glu Lys His Pro Glu Val Glu Ala Glu Ala Glu Ala Glu Ala Glu Ala 
            180                 185                 190         


Glu Ala Glu Ala Glu Ala Glu Ala Lys Ala Glu Val Glu Glu Pro Gly 
        195                 200                 205             


Ser Leu Lys Arg Ser Ala Glu Asp Glu Glu Pro His Cys Pro Leu Lys 
    210                 215                 220                 


Arg Pro Arg Glu Ala Ala Pro Gly Ala Leu Glu Met Glu Pro Ala Glu 
225                 230                 235                 240 


Glu Arg Glu Ala Glu Ala Ser Pro Phe Val Glu Glu Pro Asp Gln Ala 
                245                 250                 255     


Gln Glu Gln Leu Pro Pro Leu Glu Glu Glu Ala Thr Glu Lys Ala Val 
            260                 265                 270         


Gln Gly Leu Ile Val Gly Glu Ile Glu Gly Leu 
        275                 280             


<210>  10
<211>  272
<212>  PRT
<213>  Canis familiaris

<400>  10

Met Ser Arg Cys Cys Arg Arg Lys Tyr Glu Ser Gly Asp Leu His Leu 
1               5                   10                  15      


Val Glu Pro Asn Arg Tyr Gln Val Phe Phe Phe Gly Thr His Glu Thr 
            20                  25                  30          


Ala Phe Leu Gly Pro Lys His Leu Phe Pro Tyr Glu Glu Ser Lys Glu 
        35                  40                  45              


Lys Phe Gly Lys Pro Ser Lys Arg Arg Ser Phe Ser Glu Gly Leu Trp 
    50                  55                  60                  


Glu Ile Glu Asn Asn Pro Ser Val Arg Ala Ala Ala Asp Pro Pro Ala 
65                  70                  75                  80  


Pro Gln Glu Gln Arg Gly Ala Ala Ser Ala Gly Ala Gly Ala Gly Glu 
                85                  90                  95      


Glu Gln Leu Gln Arg Glu Glu Glu Leu Gln Arg Glu Glu Gln Gln Arg 
            100                 105                 110         


Glu Glu Gln Leu Gln Arg Glu Glu Gln Leu Gln Arg Glu Glu Glu Leu 
        115                 120                 125             


Gln Arg Glu Glu Gln Leu Gln Arg Glu Glu Gln Leu Gln Arg Glu Glu 
    130                 135                 140                 


Glu Gln Leu His Arg Ala Glu Gln Ala Arg Ala Lys Arg Ser Ala Gly 
145                 150                 155                 160 


Glu Leu Pro Glu Gly Ala Pro Lys Arg Pro Arg Glu Ala Glu Pro Glu 
                165                 170                 175     


Arg Asp Ile Trp Ala Thr Gln Gln Pro Tyr Asp Leu Asp Ala Ala Ile 
            180                 185                 190         


Ile His Ile Val Leu Ala Arg Lys Leu Arg Cys Gly Asp Val Arg Gly 
        195                 200                 205             


Leu Thr Lys Leu Val Thr Gly Val Thr Arg Ala Pro Val His Cys Trp 
    210                 215                 220                 


Ser Leu Pro Arg Ile Ala Asp Arg Leu Cys Phe Leu Val Ala Asp Gly 
225                 230                 235                 240 


Ser Ala Leu Ala Arg Asn Gly Glu Pro Trp Ser Leu Gly Glu Leu Ser 
                245                 250                 255     


Ile Glu Ser Gln Phe Ile Ser Val Ala Ser Leu Ala Thr Trp Arg Leu 
            260                 265                 270         


<210>  11
<211>  304
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Met Ser Cys Phe Ser Arg Pro Lys Tyr Lys Thr Gly Asp Leu Val Phe 
1               5                   10                  15      


Ala Lys Leu Lys Gly Tyr Ala His Trp Pro Ala Arg Ile Glu His Val 
            20                  25                  30          


Thr Glu Pro Asn Arg Tyr Gln Val Phe Phe Phe Gly Thr His Glu Thr 
        35                  40                  45              


Ala Leu Leu Gly Pro Lys His Leu Phe Pro Tyr Glu Glu Ser Lys Glu 
    50                  55                  60                  


Arg Phe Gly Lys Pro Asn Lys Arg Arg Gly Phe Ser Glu Gly Leu Trp 
65                  70                  75                  80  


Glu Ile Glu His Asp Pro Met Val Glu Ala Ser Pro Cys Leu Cys Pro 
                85                  90                  95      


Asp Glu Glu Gln Leu Cys Ala Glu Glu Pro Gly Pro Gly Glu Glu Pro 
            100                 105                 110         


Glu Pro Gly Gln Glu Leu Glu Pro Glu Ser Arg Pro Glu Leu Glu Ser 
        115                 120                 125             


Met Pro Glu Leu Glu Ala Glu Pro Arg Pro Glu Lys Glu Cys Glu Gln 
    130                 135                 140                 


Glu Pro Glu Gln Glu Pro Glu Gln Glu Pro Glu Gln Glu Leu Glu Gln 
145                 150                 155                 160 


Glu Pro Glu Leu Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
                165                 170                 175     


Glu Pro Glu Pro Glu Pro Glu Pro Gln Pro Ala Tyr Asp Leu Leu Asp 
            180                 185                 190         


Ala Lys Glu Glu Pro Gly Leu Ile Glu Ala Glu Pro Gly Asp Gln Gln 
        195                 200                 205             


Ala Glu Gln Val Arg Glu Gln His Ala Glu Ala Glu Val Met Ala Val 
    210                 215                 220                 


Val Glu Glu Pro Glu Ser Leu Lys Arg Ser Ala Glu Asp Glu Gln Pro 
225                 230                 235                 240 


His Ser Pro Pro Lys Arg Pro Arg Glu Ala Ala Pro Gly Ala Leu Glu 
                245                 250                 255     


Met Glu Pro Ala Gly Glu Arg Glu Ala Glu Ala Cys Pro Phe Val Glu 
            260                 265                 270         


Glu Pro Asp Gln Ala Gln Glu Gln Gln Thr Pro Leu Glu Glu Glu Ala 
        275                 280                 285             


Thr Glu Glu Ala Val Gln Gly Leu Met Val Gly Glu Ile Glu Gly Leu 
    290                 295                 300                 


<210>  12
<211>  2344
<212>  DNA
<213>  Homo sapiens

<400>  12
cccggcttcg cctcccgctg ccgccgccgc cgccgccgca gccgctaccg ccgctgcagc     60

cgctttccgc ggcctgggcc tctcgccgtc agcatgccac acgccttcaa gcccggggac    120

ttggtgttcg ctaagatgaa gggctaccct cactggcctg ccaggatcga cgacatcgcg    180

gatggcgccg tgaagccccc acccaacaag taccccatct ttttctttgg cacacacgaa    240

acagccttcc tgggacccaa ggacctgttc ccctacgaca aatgtaaaga caagtacggg    300

aagcccaaca agaggaaagg cttcaatgaa gggctgtggg agatccagaa caacccccac    360

gccagctaca gcgcccctcc gccagtgagc tcctccgaca gcgaggcccc cgaggccaac    420

cccgccgacg gcagtgacgc tgacgaggac gatgaggacc ggggggtcat ggccgtcaca    480

gcggtaaccg ccacagctgc cagcgacagg atggagagcg actcagactc agacaagagt    540

agcgacaaca gtggcctgaa gaggaagacg cctgcgctaa agatgtcggt ctcgaaacga    600

gcccgaaagg cctccagcga cctggatcag gccagcgtgt ccccatccga agaggagaac    660

tcggaaagct catctgagtc ggagaagacc agcgaccagg acttcacacc tgagaagaaa    720

gcagcggtcc gggcgccacg gaggggccct ctggggggac ggaaaaaaaa gaaggcgcca    780

tcagcctccg actccgactc caaggccgat tcggacgggg ccaagcctga gccggtggcc    840

atggcgcggt cggcgtcctc ctcctcctct tcctcctcct cctccgactc cgatgtgtct    900

gtgaagaagc ctccgagggg caggaagcca gcggagaagc ctctcccgaa gccgcgaggg    960

cggaaaccga agcctgaacg gcctccgtcc agctccagca gtgacagtga cagcgacgag   1020

gtggaccgca tcagtgagtg gaagcggcgg gacgaggcgc ggaggcgcga gctggaggcc   1080

cggcggcggc gagagcagga ggaggagctg cggcgcctgc gggagcagga gaaggaggag   1140

aaggagcgga ggcgcgagcg ggccgaccgc ggggaggctg agcggggcag cggcggcagc   1200

agcggggacg agctcaggga ggacgatgag cccgtcaaga agcggggacg caagggccgg   1260

ggccggggtc ccccgtcctc ctctgactcc gagcccgagg ccgagctgga gagagaggcc   1320

aagaaatcag cgaagaagcc gcagtcctca agcacagagc ccgccaggaa acctggccag   1380

aaggagaaga gagtgcggcc cgaggagaag caacaagcca agcccgtgaa ggtggagcgg   1440

acccggaagc ggtccgaggg cttctcgatg gacaggaagg tagagaagaa gaaagagccc   1500

tccgtggagg agaagctgca gaagctgcac agtgagatca agtttgccct aaaggtcgac   1560

agcccggacg tgaagaggtg cctgaatgcc ctagaggagc tgggaaccct gcaggtgacc   1620

tctcagatcc tccagaagaa cacagacgtg gtggccacct tgaagaagat tcgccgttac   1680

aaagcgaaca aggacgtaat ggagaaggca gcagaagtct atacccggct caagtcgcgg   1740

gtcctcggcc caaagatcga ggcggtgcag aaagtgaaca aggctgggat ggagaaggag   1800

aaggccgagg agaagctggc cggggaggag ctggccgggg aggaggcccc ccaggagaag   1860

gcggaggaca agcccagcac cgatctctca gccccagtga atggcgaggc cacatcacag   1920

aagggggaga gcgcagagga caaggagcac gaggagggtc gggactcgga ggaggggcca   1980

aggtgtggct cctctgaaga cctgcacgac agcgtacggg agggtcccga cctggacagg   2040

cctgggagcg accggcagga gcgcgagagg gcacgggggg actcggaggc cctggacgag   2100

gagagctgag ccgcgggcag ccaggcccag cccccgcccg agctcaggct gcccctctcc   2160

ttccccggct cgcaggagag cagagcagag aactgtgggg aacgctgtgc tgtttgtatt   2220

tgttcccttg ggtttttttt tcctgcctaa tttctgtgat ttccaaccaa catgaaatga   2280

ctataaatgg ttttttaatg aaaaaagaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2340

aaaa                                                                2344


<210>  13
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro His Ala Phe Lys Pro Gly Asp Leu Val Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Asp Ile Ala Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Pro Asn Lys Tyr Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe Pro Tyr Asp Lys Cys 
    50                  55                  60                  


Lys Asp Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Gln Asn Asn Pro His Ala Ser Tyr Ser Ala Pro Pro 
                85                  90                  95      


Pro Val Ser Ser Ser Asp Ser Glu Ala Pro Glu Ala Asn Pro Ala Asp 
            100                 105                 110         


Gly Ser Asp Ala Asp Glu Asp Asp Glu Asp Arg Gly Val Met Ala Val 
        115                 120                 125             


Thr Ala Val Thr Ala Thr Ala Ala Ser Asp Arg Met Glu Ser Asp Ser 
    130                 135                 140                 


Asp Ser Asp Lys Ser Ser Asp Asn Ser Gly Leu Lys Arg Lys Thr Pro 
145                 150                 155                 160 


Ala Leu Lys Met Ser Val Ser Lys Arg Ala Arg Lys Ala Ser Ser Asp 
                165                 170                 175     


Leu Asp Gln Ala Ser Val Ser Pro Ser Glu Glu Glu Asn Ser Glu Ser 
            180                 185                 190         


Ser Ser Glu Ser Glu Lys Thr Ser Asp Gln Asp Phe Thr Pro Glu Lys 
        195                 200                 205             


Lys Ala Ala Val Arg Ala Pro Arg Arg Gly Pro Leu Gly Gly Arg Lys 
    210                 215                 220                 


Lys Lys Lys Ala Pro Ser Ala Ser Asp Ser Asp Ser Lys Ala Asp Ser 
225                 230                 235                 240 


Asp Gly Ala Lys Pro Glu Pro Val Ala Met Ala Arg Ser Ala Ser Ser 
                245                 250                 255     


Ser Ser Ser Ser Ser Ser Ser Ser Asp Ser Asp Val Ser Val Lys Lys 
            260                 265                 270         


Pro Pro Arg Gly Arg Lys Pro Ala Glu Lys Pro Leu Pro Lys Pro Arg 
        275                 280                 285             


Gly Arg Lys Pro Lys Pro Glu Arg Pro Pro Ser Ser Ser Ser Ser Asp 
    290                 295                 300                 


Ser Asp Ser Asp Glu Val Asp Arg Ile Ser Glu Trp Lys Arg Arg Asp 
305                 310                 315                 320 


Glu Ala Arg Arg Arg Glu Leu Glu Ala Arg Arg Arg Arg Glu Gln Glu 
                325                 330                 335     


Glu Glu Leu Arg Arg Leu Arg Glu Gln Glu Lys Glu Glu Lys Glu Arg 
            340                 345                 350         


Arg Arg Glu Arg Ala Asp Arg Gly Glu Ala Glu Arg Gly Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Asp Glu Leu Arg Glu Asp Asp Glu Pro Val Lys Lys Arg 
    370                 375                 380                 


Gly Arg Lys Gly Arg Gly Arg Gly Pro Pro Ser Ser Ser Asp Ser Glu 
385                 390                 395                 400 


Pro Glu Ala Glu Leu Glu Arg Glu Ala Lys Lys Ser Ala Lys Lys Pro 
                405                 410                 415     


Gln Ser Ser Ser Thr Glu Pro Ala Arg Lys Pro Gly Gln Lys Glu Lys 
            420                 425                 430         


Arg Val Arg Pro Glu Glu Lys Gln Gln Ala Lys Pro Val Lys Val Glu 
        435                 440                 445             


Arg Thr Arg Lys Arg Ser Glu Gly Phe Ser Met Asp Arg Lys Val Glu 
    450                 455                 460                 


Lys Lys Lys Glu Pro Ser Val Glu Glu Lys Leu Gln Lys Leu His Ser 
465                 470                 475                 480 


Glu Ile Lys Phe Ala Leu Lys Val Asp Ser Pro Asp Val Lys Arg Cys 
                485                 490                 495     


Leu Asn Ala Leu Glu Glu Leu Gly Thr Leu Gln Val Thr Ser Gln Ile 
            500                 505                 510         


Leu Gln Lys Asn Thr Asp Val Val Ala Thr Leu Lys Lys Ile Arg Arg 
        515                 520                 525             


Tyr Lys Ala Asn Lys Asp Val Met Glu Lys Ala Ala Glu Val Tyr Thr 
    530                 535                 540                 


Arg Leu Lys Ser Arg Val Leu Gly Pro Lys Ile Glu Ala Val Gln Lys 
545                 550                 555                 560 


Val Asn Lys Ala Gly Met Glu Lys Glu Lys Ala Glu Glu Lys Leu Ala 
                565                 570                 575     


Gly Glu Glu Leu Ala Gly Glu Glu Ala Pro Gln Glu Lys Ala Glu Asp 
            580                 585                 590         


Lys Pro Ser Thr Asp Leu Ser Ala Pro Val Asn Gly Glu Ala Thr Ser 
        595                 600                 605             


Gln Lys Gly Glu Ser Ala Glu Asp Lys Glu His Glu Glu Gly Arg Asp 
    610                 615                 620                 


Ser Glu Glu Gly Pro Arg Cys Gly Ser Ser Glu Asp Leu His Asp Ser 
625                 630                 635                 640 


Val Arg Glu Gly Pro Asp Leu Asp Arg Pro Gly Ser Asp Arg Gln Glu 
                645                 650                 655     


Arg Glu Arg Ala Arg Gly Asp Ser Glu Ala Leu Asp Glu Glu Ser 
            660                 665                 670     


<210>  14
<211>  669
<212>  PRT
<213>  Mus musculus

<400>  14

Met Pro His Ala Phe Lys Pro Gly Asp Leu Val Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Asp Ile Ala Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Pro Asn Lys Tyr Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe Pro Tyr Asp Lys Cys 
    50                  55                  60                  


Lys Asp Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Gln Asn Asn Pro His Ala Ser Tyr Ser Ala Pro Pro 
                85                  90                  95      


Pro Val Ser Ser Ser Asp Ser Glu Ala Pro Glu Ala Asp Leu Gly Cys 
            100                 105                 110         


Gly Ser Asp Val Asp Lys Asp Lys Glu Ser Arg Arg Val Met Thr Val 
        115                 120                 125             


Thr Ala Val Thr Thr Thr Ala Thr Ser Asp Arg Met Glu Ser Asp Ser 
    130                 135                 140                 


Asp Ser Asp Lys Ser Ser Asp His Ser Gly Leu Lys Arg Lys Thr Pro 
145                 150                 155                 160 


Val Leu Lys Val Ser Val Ser Lys Arg Ala Arg Arg Ala Ser Ser Asp 
                165                 170                 175     


Leu Asp Gln Ala Ser Val Ser Pro Ser Glu Glu Asp Ser Glu Ser Pro 
            180                 185                 190         


Ser Glu Ser Glu Lys Thr Ser Asp Gln Asp Phe Thr Pro Glu Lys Lys 
        195                 200                 205             


Thr Ala Ala Arg Pro Pro Arg Arg Gly Pro Leu Gly Gly Arg Lys Lys 
    210                 215                 220                 


Lys Lys Val Pro Ser Ala Ser Asp Ser Asp Ser Lys Ala Asp Ser Asp 
225                 230                 235                 240 


Gly Ala Lys Glu Glu Pro Val Val Thr Ala Gln Pro Ser Pro Ser Ser 
                245                 250                 255     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Ser Asp Val Ser Val 
            260                 265                 270         


Lys Lys Pro Pro Arg Gly Arg Lys Pro Ala Glu Lys Pro Pro Pro Lys 
        275                 280                 285             


Pro Arg Gly Arg Arg Pro Lys Pro Glu Arg Pro Pro Ser Thr Ser Ser 
    290                 295                 300                 


Ser Asp Ser Asp Ser Asp Ser Gly Glu Val Asp Arg Ile Ser Glu Trp 
305                 310                 315                 320 


Lys Arg Arg Asp Glu Glu Arg Arg Arg Glu Leu Glu Ala Arg Arg Arg 
                325                 330                 335     


Arg Glu Gln Glu Glu Glu Leu Arg Arg Leu Arg Glu Gln Glu Arg Glu 
            340                 345                 350         


Glu Lys Glu Arg Arg Lys Glu Arg Ala Glu Arg Gly Gly Ser Ser Gly 
        355                 360                 365             


Glu Glu Leu Glu Asp Glu Glu Pro Val Lys Lys Arg Ser Arg Lys Ala 
    370                 375                 380                 


Arg Gly Arg Gly Thr Pro Ser Ser Ser Asp Ser Glu Pro Glu Gly Glu 
385                 390                 395                 400 


Leu Gly Lys Glu Gly Lys Lys Leu Ala Lys Lys Ser Gln Leu Pro Gly 
                405                 410                 415     


Ser Glu Ser Ala Arg Lys Pro Gly Gln Lys Glu Lys Arg Gly Arg Pro 
            420                 425                 430         


Asp Glu Lys Pro Arg Ala Arg Pro Val Lys Val Glu Arg Thr Arg Lys 
        435                 440                 445             


Arg Ser Glu Gly Leu Ser Leu Glu Arg Lys Gly Glu Lys Lys Lys Glu 
    450                 455                 460                 


Pro Ser Val Glu Glu Arg Leu Gln Lys Leu His Ser Glu Ile Lys Phe 
465                 470                 475                 480 


Ala Leu Lys Val Asp Asn Pro Asp Val Arg Lys Cys Leu Ser Ala Leu 
                485                 490                 495     


Glu Glu Leu Gly Thr Leu Gln Val Thr Ser Gln Ile Leu Gln Lys Asn 
            500                 505                 510         


Thr Asp Val Val Ala Thr Leu Lys Lys Ile Arg Arg Tyr Lys Ala Asn 
        515                 520                 525             


Lys Asp Val Met Ala Lys Ala Ala Glu Val Tyr Thr Arg Leu Lys Ser 
    530                 535                 540                 


Arg Val Leu Gly Pro Lys Val Glu Ala Leu Gln Lys Val Asn Lys Ala 
545                 550                 555                 560 


Gly Ala Glu Lys Glu Arg Ala Asp Asn Glu Lys Leu Glu Glu Gln Pro 
                565                 570                 575     


Gly Glu Gln Ala Pro Arg Glu Leu Ala Glu Asp Glu Pro Ser Thr Asp 
            580                 585                 590         


Arg Ser Ala Pro Val Asn Gly Glu Ala Thr Ser Gln Lys Gly Glu Asn 
        595                 600                 605             


Met Glu Asp Arg Ala Gln Glu Asp Gly Gln Asp Ser Glu Asp Gly Pro 
    610                 615                 620                 


Arg Gly Gly Ser Ser Glu Glu Leu His Asp Ser Pro Arg Asp Asn Ser 
625                 630                 635                 640 


Asp Pro Ala Lys Pro Gly Asn Glu Arg Gln Asp His Glu Arg Thr Arg 
                645                 650                 655     


Leu Ala Ser Glu Ser Ala Asn Asp Asp Asn Glu Asp Ser 
            660                 665                 


<210>  15
<211>  226
<212>  PRT
<213>  Pan troglodytes

<400>  15

Met Glu Glu Lys Pro Pro Ala Arg Val Gly Arg Leu Pro Arg Gln Pro 
1               5                   10                  15      


Pro Pro Pro Pro Arg Arg Pro Ala Pro Ala Pro Gly Phe Ala Ser Arg 
            20                  25                  30          


Cys Arg Arg Arg Arg Arg Arg Ser Arg Tyr Arg Arg Cys Ser Arg Phe 
        35                  40                  45              


Pro Arg Pro Gly Pro Leu Ala Val Ser Met Pro His Ala Phe Lys Pro 
    50                  55                  60                  


Gly Asp Leu Val Phe Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala 
65                  70                  75                  80  


Arg Ile Asp Asp Ile Ala Asp Gly Ala Val Lys Pro Pro Pro Asn Lys 
                85                  90                  95      


Tyr Pro Ile Phe Phe Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro 
            100                 105                 110         


Lys Asp Leu Phe Pro Tyr Asp Lys Cys Lys Asp Lys Tyr Gly Lys Pro 
        115                 120                 125             


Asn Lys Arg Lys Gly Phe Asn Glu Gly Leu Trp Glu Ile Gln Asn Asn 
    130                 135                 140                 


Pro His Ala Ser Tyr Ser Ala Pro Pro Pro Val Ser Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Ala Pro Glu Ala Asn Pro Ala Gly Gly Ser Asp Ala Asp Glu Asp 
                165                 170                 175     


Asp Glu Asp Arg Gly Val Met Ala Val Thr Ala Val Thr Ala Thr Ala 
            180                 185                 190         


Ala Ser Asp Arg Met Glu Ser Asp Ser Asp Ser Asp Lys Ser Ser Asp 
        195                 200                 205             


Asn Ser Gly Leu Lys Arg Lys Thr Pro Ala Leu Lys Lys Gln Arg Thr 
    210                 215                 220                 


Arg Phe 
225     


<210>  16
<211>  649
<212>  PRT
<213>  Canis familiaris

<400>  16

Met Pro Asn Trp Lys Ile Asp Asp Ile Ala Asp Gly Ala Val Lys Pro 
1               5                   10                  15      


Pro Pro Asn Lys Tyr Pro Ile Phe Phe Phe Gly Thr His Glu Thr Ala 
            20                  25                  30          


Phe Leu Gly Pro Lys Asp Leu Phe Pro Tyr Asp Lys Cys Lys Asp Lys 
        35                  40                  45              


Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly Leu Trp Glu 
    50                  55                  60                  


Ile Gln Asn Asn Pro His Ala Ser Tyr Ser Ala Pro Leu Pro Val Ser 
65                  70                  75                  80  


Ser Ser Asp Ser Glu Ala Pro Glu Ala Asp Pro Ala Gly Gly Ser Glu 
                85                  90                  95      


Asp Asp Glu Val Arg Gly Val Met Ala Val Thr Ala Val Thr Ala Thr 
            100                 105                 110         


Ala Ala Ser Asp Arg Met Glu Ser Asp Ser Asp Ser Asp Lys Ser Ser 
        115                 120                 125             


Asp Asn Ser Gly Leu Lys Arg Lys Ala Ala Ala Leu Lys Met Ser Val 
    130                 135                 140                 


Ser Lys Arg Thr Arg Lys Ala Ser Ser Asp Leu Asp Gln Ala Ser Val 
145                 150                 155                 160 


Ser Pro Ser Glu Glu Glu Asn Ser Glu Ser Ser Ser Glu Ser Glu Lys 
                165                 170                 175     


Thr Ser Asp Gln Asp Phe Thr Pro Glu Lys Lys Ala Val Val Arg Ala 
            180                 185                 190         


Pro Arg Arg Gly Pro Leu Ala Gly Arg Lys Lys Lys Lys Ala Pro Ser 
        195                 200                 205             


Ala Ser Asp Ser Asp Ser Lys Ala Glu Ser Asp Gly Ala Lys Val Glu 
    210                 215                 220                 


Pro Val Ala Val Ala Arg Ser Ala Pro Ser Ser Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Asp Ser Asp Val Ser Val Lys Lys Pro Pro Arg 
                245                 250                 255     


Gly Arg Lys Pro Ala Glu Lys Pro Pro Pro Lys Pro Arg Gly Arg Lys 
            260                 265                 270         


Pro Lys Pro Glu Arg Pro Pro Thr Ser Ser Ser Ser Asp Ser Asp Ser 
        275                 280                 285             


Asp Glu Val Asp Arg Ile Ser Glu Trp Lys Arg Arg Asp Glu Glu Arg 
    290                 295                 300                 


Arg Arg Glu Leu Glu Ala Arg Arg Arg Arg Glu Gln Glu Glu Glu Leu 
305                 310                 315                 320 


Arg Arg Leu Arg Glu Gln Glu Lys Glu Glu Lys Glu Arg Arg Arg Glu 
                325                 330                 335     


Arg Glu Arg Gly Glu Ala Pro Ala Ser Gly Gly Ser Ser Gly Asp Glu 
            340                 345                 350         


Leu Gly Asp Glu Asp Glu Pro Val Arg Lys Arg Gly Arg Lys Gly Arg 
        355                 360                 365             


Gly Arg Gly Pro Gln Ser Ser Ser Asp Ser Gly Pro Glu Ala Glu Leu 
    370                 375                 380                 


Gln Arg Glu Ala Lys Lys Thr Ala Arg Gln Ser Thr Glu Pro Thr Arg 
385                 390                 395                 400 


Arg Pro Ser Gln Lys Glu Lys Arg Gly Arg Pro Glu Glu Arg Pro Arg 
                405                 410                 415     


Ala Arg Pro Ala Lys Val Glu Arg Thr Arg Lys Arg Ser Glu Gly Phe 
            420                 425                 430         


Pro Pro Asp Arg Lys Val Glu Lys Lys Lys Glu Pro Ser Val Glu Glu 
        435                 440                 445             


Lys Leu Gln Lys Leu His Ser Glu Ile Lys Phe Ala Leu Lys Val Asp 
    450                 455                 460                 


Asn Pro Asp Val Lys Arg Cys Leu Asn Ala Leu Glu Glu Leu Gly Thr 
465                 470                 475                 480 


Leu Gln Val Thr Ser Gln Ile Leu Gln Lys Asn Thr Asp Val Val Ala 
                485                 490                 495     


Thr Leu Lys Lys Ile Arg Arg Tyr Lys Ala Asn Lys Glu Val Met Glu 
            500                 505                 510         


Lys Ala Ala Glu Val Tyr Thr Arg Leu Lys Ser Arg Val Leu Gly Pro 
        515                 520                 525             


Lys Ile Glu Ala Ile Gln Lys Ala Thr Arg Ala Gly Val Glu Lys Glu 
    530                 535                 540                 


Arg Ala Glu Val Glu Lys Ala Glu Glu Ala Leu Ala Gly Glu Glu Ala 
545                 550                 555                 560 


Pro Met Glu Arg Val Glu Asp Glu Ala Asn Ala Asp Leu Ser Ala Pro 
                565                 570                 575     


Val Asn Gly Glu Ala Thr Ser Gln Lys Gly Glu Ser Met Glu Asp Lys 
            580                 585                 590         


Glu Gln Glu Gly Gly Gln Asn Ser Glu Glu Gly Leu Gly Cys Gly Ser 
        595                 600                 605             


Ser Glu Glu Pro Leu His Asn Asp Asn Ala Arg Glu Gly Ser Glu Leu 
    610                 615                 620                 


Asp Ala Pro Gly Lys Glu Arg Gln Glu Arg Ala Arg Val Arg Met Asp 
625                 630                 635                 640 


Ser Glu Ser Leu Asp Glu Glu Asp Ser 
                645                 


<210>  17
<211>  630
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Met Pro His Ala Phe Lys Pro Gly Asp Leu Val Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Asp Ile Ala Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Pro Asn Lys Tyr Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe Pro Tyr Asp Lys Cys 
    50                  55                  60                  


Lys Asp Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Gln Asn Asn Pro His Ala Ser Tyr Ser Ala Pro Leu 
                85                  90                  95      


Pro Val Ser Ser Ser Asp Ser Glu Ala Pro Glu Ala Asp Leu Gly Gly 
            100                 105                 110         


Gly Ser Asp Ala Asp Lys Glu Lys Glu Ala Arg Arg Val Met Thr Val 
        115                 120                 125             


Thr Ala Val Thr Thr Thr Ala Thr Ser Gly Arg Thr Glu Ser Asp Ser 
    130                 135                 140                 


Asp Ser Asp Lys Asn Ser Asp His Ser Gly Leu Lys Arg Lys Thr Pro 
145                 150                 155                 160 


Val Leu Lys Met Ser Val Ser Lys Arg Ala Arg Lys Ala Ser Ser Asp 
                165                 170                 175     


Leu Asp Gln Ala Ser Val Ser Pro Ser Glu Glu Asp Ser Glu Ser Pro 
            180                 185                 190         


Ser Glu Ser Glu Lys Thr Ser Asp Gln Asp Phe Thr Pro Glu Lys Lys 
        195                 200                 205             


Thr Ile Ala Arg Ala Pro Arg Arg Ala Pro Leu Gly Gly Arg Lys Lys 
    210                 215                 220                 


Lys Lys Val Pro Ser Ala Ser Asp Ser Asp Ser Arg Ala Asp Ser Asp 
225                 230                 235                 240 


Gly Ala Lys Glu Glu Pro Val Val Thr Ala Gln Pro Ser Pro Ser Ser 
                245                 250                 255     


Ala Ser Ser Ser Ser Ser Ser Ser Ala Ser Asp Ser Asp Val Ser Ile 
            260                 265                 270         


Lys Lys Pro Pro Arg Gly Arg Lys Pro Ala Glu Lys Pro Pro Pro Lys 
        275                 280                 285             


Pro Arg Gly Arg Arg Ser Lys Pro Glu Arg Pro Pro Ser Thr Ser Ser 
    290                 295                 300                 


Ser Asp Ser Asp Ser Asp Ser Gly Glu Val Asp Arg Ile Ser Glu Trp 
305                 310                 315                 320 


Lys Arg Arg Asp Glu Glu Arg Arg Arg Glu Leu Glu Ala Arg Arg Arg 
                325                 330                 335     


Arg Glu Gln Glu Glu Glu Leu Arg Arg Leu Arg Glu Gln Glu Arg Glu 
            340                 345                 350         


Glu Lys Glu Arg Arg Lys Glu Arg Ala Glu Arg Gly Gly Ser Ser Gly 
        355                 360                 365             


Glu Glu Leu Glu Asp Glu Glu Pro Val Lys Lys Arg Ser Arg Lys Ala 
    370                 375                 380                 


Arg Gly Arg Gly Thr Pro Ser Ser Ser Asp Ser Glu Pro Glu Gly Glu 
385                 390                 395                 400 


Leu Gly Lys Glu Gly Lys Lys Leu Ala Lys Lys Ser Gln Leu Gln Gly 
                405                 410                 415     


Ser Glu Ser Ala Arg Lys Pro Gly Gln Lys Glu Lys Arg Gly Arg Pro 
            420                 425                 430         


Asp Glu Lys Pro Arg Ala Arg Pro Val Lys Val Glu Arg Thr Arg Lys 
        435                 440                 445             


Arg Ser Glu Gly Leu Ser Leu Asp Arg Lys Gly Glu Lys Lys Lys Glu 
    450                 455                 460                 


Pro Ser Val Glu Glu Arg Leu Gln Lys Leu His Ser Glu Ile Lys Phe 
465                 470                 475                 480 


Ala Leu Lys Val Asp Asn Pro Asp Val Arg Arg Cys Leu Ser Ala Leu 
                485                 490                 495     


Glu Glu Leu Gly Thr Leu Gln Val Thr Ser Gln Ile Leu Gln Lys Asn 
            500                 505                 510         


Thr Asp Val Val Ala Thr Leu Lys Lys Ile Arg Arg Tyr Lys Ala Asn 
        515                 520                 525             


Lys Asp Val Met Ala Lys Ala Ala Glu Val Tyr Thr Arg Leu Lys Ser 
    530                 535                 540                 


Arg Val Leu Gly Pro Lys Val Glu Ala Leu Gln Lys Val Asn Lys Ala 
545                 550                 555                 560 


Gly Ala Glu Lys Glu Arg Ala Asp Gly Glu Lys Val Glu Glu Gln Pro 
                565                 570                 575     


Gly Glu Gln Ala Pro Arg Glu Leu Ala Glu Asp Glu Pro Ser Thr Asp 
            580                 585                 590         


Arg Ser Ala Pro Val Asn Gly Glu Ala Ala Ser Gln Lys Gly Glu Asn 
        595                 600                 605             


Thr Glu Asp Gly Ala Gln Glu Asp Gly Gln Asp Leu Glu Asp Gly Pro 
    610                 615                 620                 


Arg Gly Gly Ser Ser Glu 
625                 630 


<210>  18
<211>  1973
<212>  DNA
<213>  Homo sapiens

<400>  18
agccgccgcc tcgccgcttc ccctcgtcgg agcggccgct cgtccgcccg gcttgaggcc     60

cgcggggagc gcggcgcaat tcgtcggccc gcgggggggc ggcctcccgg catcttcgcg    120

gcgaccaagg actaccagga aggggagcgg ctgggatggc gcgtccgcgg ccccgcgagt    180

acaaagcggg cgacctggtc ttcgccaaga tgaagggcta cccgcactgg ccggcccgga    240

ttgatgaact cccagagggc gctgtgaagc ctccagcaaa caagtatcct atcttctttt    300

ttggcaccca tgaaactgca tttctaggtc ccaaagacct ttttccatat aaggagtaca    360

aagacaagtt tggaaagtca aacaaacgga aaggatttaa cgaaggattg tgggaaatag    420

aaaataaccc aggagtaaag tttactggct accaggcaat tcagcaacag agctcttcag    480

aaactgaggg agaaggtgga aatactgcag atgcaagcag tgaggaagaa ggtgatagag    540

tagaagaaga tggaaaaggc aaaagaaaga atgaaaaagc aggctcaaaa cggaaaaagt    600

catatacttc aaagaaatcc tctaaacagt cccggaaatc tccaggagat gaagatgaca    660

aagactgcaa agaagaggaa aacaaaagca gctctgaggg tggagatgcg ggcaacgaca    720

caagaaacac aacttcagac ttgcagaaaa ccagtgaagg gacctaacta ccataatgaa    780

tgctgcatat taagagaaac cacaagaagg ttatatgttt ggttgtctaa tattcttgga    840

tttgatatga accaacacat agtccttgtt gtcattgaca gaaccccagt ttgtatgtac    900

attattcata ttcctctctg ttgtgtttcg gggggaaaag acattttagc cttttttaaa    960

agttactgat ttaatttcat gttatttggt tgcatgaagt tgcccttaac cactaaggat   1020

tatcaagatt tttgcgcaga cttatacatg tctaggatcc ttttatcaag gcagttatga   1080

tcatcgtttt cctgccttga ccccaccatc atcaaacact cagttaaata taaattaaca   1140

ttttttagat gaccactcaa cataatgctt aagaatggaa tttcctctct gtgacagaac   1200

ccaggaatta attcctaaat acataacgtt ggtatattga agacgaaatt aaaattgtcc   1260

ttcagttttg aggccatgtg taaagtttaa ccatattgta aaatatctat tccgtattag   1320

aaatagctag ttgacagctt atacttctca aaattcatat tgttatgtac acaaactaag   1380

tttctatatg tgaagttagt gagtcttttt gtgttactcc aaaataaagg caatgattta   1440

tttttttccc agtgccaata caattttgag ctaagcactc aaggtggata ctttacattt   1500

taaagctgga atcagcaaca gccctatggg aaaccagaca aagcattgac ttttaaatgt   1560

agacttttaa aataaactgt tttcttttgg aactacaatt agaatagtta atattcatcc   1620

ttaaaccatt attatgtgta cattattgtt gctattgtga taatagagaa ttttatttat   1680

ttttatgcca gcttatattg tgagaacaca tttagtcagt ttgggtttta tcaatcctgt   1740

taatgcttgt ccttggaaca tctttcgcgt attcacggtt tgtagttgaa aagtttactg   1800

taaaaaaatc aaaaacaaaa aaatgtattg tttttacaga ataaatttat tgggatgtgt   1860

actgggagta agatttgagg ttgtaagcaa actaagttag tgtaatttgg cttcatatat   1920

gtaacgtgag gtattaatgt aattcatata ttaaagcaaa aattgttcgc agc          1973


<210>  19
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Arg Pro Arg Pro Arg Glu Tyr Lys Ala Gly Asp Leu Val Phe 
1               5                   10                  15      


Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu Leu 
            20                  25                  30          


Pro Glu Gly Ala Val Lys Pro Pro Ala Asn Lys Tyr Pro Ile Phe Phe 
        35                  40                  45              


Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe Pro 
    50                  55                  60                  


Tyr Lys Glu Tyr Lys Asp Lys Phe Gly Lys Ser Asn Lys Arg Lys Gly 
65                  70                  75                  80  


Phe Asn Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Gly Val Lys Phe 
                85                  90                  95      


Thr Gly Tyr Gln Ala Ile Gln Gln Gln Ser Ser Ser Glu Thr Glu Gly 
            100                 105                 110         


Glu Gly Gly Asn Thr Ala Asp Ala Ser Ser Glu Glu Glu Gly Asp Arg 
        115                 120                 125             


Val Glu Glu Asp Gly Lys Gly Lys Arg Lys Asn Glu Lys Ala Gly Ser 
    130                 135                 140                 


Lys Arg Lys Lys Ser Tyr Thr Ser Lys Lys Ser Ser Lys Gln Ser Arg 
145                 150                 155                 160 


Lys Ser Pro Gly Asp Glu Asp Asp Lys Asp Cys Lys Glu Glu Glu Asn 
                165                 170                 175     


Lys Ser Ser Ser Glu Gly Gly Asp Ala Gly Asn Asp Thr Arg Asn Thr 
            180                 185                 190         


Thr Ser Asp Leu Gln Lys Thr Ser Glu Gly Thr 
        195                 200             


<210>  20
<211>  207
<212>  PRT
<213>  Canis familiaris

<400>  20

Met Val Ile Asn Leu Arg Asp Leu Ser Gly Ala Glu Leu Gly Glu Leu 
1               5                   10                  15      


Gly Glu Lys Leu Asn Thr Gly Leu Glu Glu Ile Thr Asn Lys Ile Lys 
            20                  25                  30          


Ile Asp Glu Leu Pro Glu Gly Ala Val Lys Pro Pro Ala Asn Lys Tyr 
        35                  40                  45              


Pro Ile Phe Phe Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys 
    50                  55                  60                  


Asp Leu Phe Pro Tyr Lys Glu Tyr Lys Asp Lys Phe Gly Lys Ser Asn 
65                  70                  75                  80  


Lys Arg Lys Gly Phe Asn Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro 
                85                  90                  95      


Gly Val Lys Phe Thr Gly Tyr Gln Ala Ile Gln Gln Gln Ser Ser Ser 
            100                 105                 110         


Glu Thr Glu Gly Glu Gly Gly Asn Thr Ala Asp Ala Ser Ser Glu Glu 
        115                 120                 125             


Glu Gly Asp Arg Val Glu Glu Asp Gly Lys Gly Lys Arg Lys Asn Glu 
    130                 135                 140                 


Lys Ala Gly Ser Lys Arg Lys Lys Ser Tyr Thr Ser Lys Lys Ser Ser 
145                 150                 155                 160 


Lys Gln Ser Arg Lys Ser Pro Gly Asp Glu Asp Asp Lys Asp Cys Lys 
                165                 170                 175     


Glu Glu Glu Asn Lys Ser Ser Ser Glu Gly Gly Asp Ala Gly Asn Asp 
            180                 185                 190         


Thr Arg Asn Thr Thr Ser Asp Leu Gln Lys Thr Ser Glu Gly Thr 
        195                 200                 205         


<210>  21
<211>  202
<212>  PRT
<213>  Mus musculus

<400>  21

Met Ala Arg Pro Arg Pro Arg Glu Tyr Lys Ala Gly Asp Leu Val Phe 
1               5                   10                  15      


Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu Leu 
            20                  25                  30          


Pro Glu Gly Ala Val Lys Pro Pro Ala Asn Lys Tyr Pro Ile Phe Phe 
        35                  40                  45              


Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe Pro 
    50                  55                  60                  


Tyr Lys Glu Tyr Lys Asp Lys Phe Gly Lys Ser Asn Lys Arg Lys Gly 
65                  70                  75                  80  


Phe Asn Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Gly Val Lys Phe 
                85                  90                  95      


Thr Gly Tyr Gln Thr Ile Gln Gln Gln Ser Ser Ser Glu Thr Glu Gly 
            100                 105                 110         


Glu Gly Gly Asn Thr Ala Asp Ala Ser Ser Glu Glu Glu Gly Asp Arg 
        115                 120                 125             


Val Glu Asp Gly Lys Gly Lys Arg Lys Asn Glu Lys Gly Gly Ser Lys 
    130                 135                 140                 


Arg Lys Lys Ser Tyr Thr Ser Lys Lys Ser Ser Lys Gln Ser Arg Lys 
145                 150                 155                 160 


Ser Pro Gly Asp Glu Asp Asp Lys Asp Cys Lys Glu Glu Glu Asn Lys 
                165                 170                 175     


Ser Ser Ser Glu Gly Gly Asp Ala Gly Asn Asp Thr Arg Asn Thr Thr 
            180                 185                 190         


Ala Asp Leu Gln Lys Ala Gly Glu Gly Thr 
        195                 200         


<210>  22
<211>  202
<212>  PRT
<213>  Rattus norvegicus

<400>  22

Met Ala Arg Pro Arg Pro Arg Glu Tyr Lys Ala Gly Asp Leu Val Phe 
1               5                   10                  15      


Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu Leu 
            20                  25                  30          


Pro Glu Gly Ala Val Lys Pro Pro Ala Asn Lys Tyr Pro Ile Phe Phe 
        35                  40                  45              


Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe Pro 
    50                  55                  60                  


Tyr Lys Glu Tyr Lys Asp Lys Phe Gly Lys Ser Asn Lys Arg Lys Gly 
65                  70                  75                  80  


Phe Asn Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Gly Val Lys Phe 
                85                  90                  95      


Thr Gly Tyr Gln Thr Ile Gln Gln Gln Ser Ser Ser Glu Thr Glu Gly 
            100                 105                 110         


Glu Gly Gly Asn Thr Ala Asp Ala Ser Ser Glu Glu Glu Gly Asp Arg 
        115                 120                 125             


Val Glu Asp Gly Lys Gly Lys Arg Lys Asn Glu Lys Gly Gly Ser Lys 
    130                 135                 140                 


Arg Lys Lys Ser Tyr Thr Ser Lys Lys Ser Ser Lys Gln Ser Arg Lys 
145                 150                 155                 160 


Ser Pro Gly Asp Glu Asp Asp Lys Asp Cys Lys Glu Glu Glu Asn Lys 
                165                 170                 175     


Ser Ser Ser Glu Gly Gly Asp Ala Gly Asn Asp Thr Arg Asn Thr Thr 
            180                 185                 190         


Ser Asp Leu Gln Lys Ala Gly Glu Gly Thr 
        195                 200         


<210>  23
<211>  539
<212>  PRT
<213>  Gallus gallus

<400>  23

Met Glu Thr Thr Leu Asn Val Trp Ile Leu Ser Lys Lys Ala Gly Leu 
1               5                   10                  15      


Pro Val Thr Gln Trp Gln Glu Leu His Leu Ser Lys Thr Val Cys Gln 
            20                  25                  30          


Leu His Arg Ser Gly Arg Ala Ile Ala Glu Gly Gly Ala Val Val Lys 
        35                  40                  45              


Thr Ala Val Cys Gly Gln Leu Leu Ser Leu Gln Arg Pro Lys Ala Val 
    50                  55                  60                  


Tyr Ser Cys Phe Ser Ala Ala Ala Pro Thr Ala Asn Lys Thr Gly Pro 
65                  70                  75                  80  


Gly Gly Gly Arg Leu Ala Val Pro Arg Gly Pro Gly Gly Cys Asp Leu 
                85                  90                  95      


Pro Cys Ala Gln Ala Gly Thr Leu Leu Gln Gln Val Ser Arg Ala Val 
            100                 105                 110         


Pro Phe Phe Val Ser Gln Val Phe Val Ser Thr Pro Cys Lys Leu Gln 
        115                 120                 125             


Cys Ala Lys Val Ser Val Arg Thr Ser Gly Thr Ser Phe Ser Ser Arg 
    130                 135                 140                 


Leu Asp Arg Glu Gly Gln Arg Pro Gly Gln Gly Glu Pro Asn Gly Leu 
145                 150                 155                 160 


Leu Gly Ser Pro Ser Ala Ile Phe Ser Ser Ala Gln Lys Ser His Pro 
                165                 170                 175     


Asp Arg Leu Glu Phe Val Leu Leu Thr Asn Ser Lys Ser Ala Ala Gln 
            180                 185                 190         


Gly Val Trp Ala Ala Leu Leu Ser Leu Gly Ala Ile Ala Trp Thr Trp 
        195                 200                 205             


Asp Ala Leu Cys Cys Val Arg Gln Arg Cys Leu Cys Leu Asp Cys Cys 
    210                 215                 220                 


Ser Asn Gly Lys Gln Ser Ser Ala Glu Gln Asn Thr Gln Glu Gly Leu 
225                 230                 235                 240 


Gln Pro Pro Leu Leu Pro His Gln Leu Phe Gln Gly Ala Asp Pro Pro 
                245                 250                 255     


Ala Ser Ser Cys Arg Gly Cys Phe Val Asp Gly Glu Pro Cys Cys Ser 
            260                 265                 270         


Arg Gly Ala Ala Gln Cys Trp Gly Cys Gly Ala Ala Ala Ala Glu Thr 
        275                 280                 285             


Val Asn Phe Glu Leu Asp Lys Met Glu Gly Gln Gly Asn Gly Gln Lys 
    290                 295                 300                 


Gln Ala Val Gly Leu Gln Gly Lys Glu Ser Ala Gly Ala Ser Ser Leu 
305                 310                 315                 320 


Val Cys Val Val Cys Ser Thr Pro Gly Ala Thr Ile Thr Thr Ser Val 
                325                 330                 335     


Arg Glu Phe Leu Ser Gln Leu Gly Arg Ala Leu Pro Gln Asp Pro Thr 
            340                 345                 350         


Val Gly Ser Asn Ala Val Ser Ile Ser Val Ser Gln Ile Asp Glu Leu 
        355                 360                 365             


Pro Glu Gly Ala Val Lys Pro Pro Ala Asn Lys Tyr Pro Ile Phe Phe 
    370                 375                 380                 


Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe Pro 
385                 390                 395                 400 


Tyr Lys Glu Tyr Lys Asp Lys Phe Gly Lys Ser Asn Lys Arg Lys Gly 
                405                 410                 415     


Phe Asn Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Gly Val Lys Phe 
            420                 425                 430         


Thr Gly Tyr Gln Ala Ile Gln Gln Gln Ser Ser Ser Glu Thr Glu Gly 
        435                 440                 445             


Glu Gly Gly Asn Thr Ala Asp Ala Ser Ser Glu Glu Glu Gly Asp Arg 
    450                 455                 460                 


Val Glu Glu Asp Gly Lys Gly Lys Arg Lys Asn Glu Lys Ala Gly Ser 
465                 470                 475                 480 


Lys Arg Lys Lys Ser Tyr Thr Ser Lys Lys Ser Ser Lys Gln Ser Arg 
                485                 490                 495     


Lys Ser Pro Gly Asp Glu Asp Asp Lys Asp Cys Lys Glu Glu Glu Asn 
            500                 505                 510         


Lys Ser Ser Ser Asp Ala Gly Asp Ala Gly Asn Asp Thr Arg Asn Thr 
        515                 520                 525             


Ser Ser Asp Leu Gln Lys Thr Ser Glu Gly Thr 
    530                 535                 


<210>  24
<211>  235
<212>  PRT
<213>  Bos taurus

<400>  24

Met Ser Arg Phe Tyr Arg Arg Lys Tyr Lys Cys Gly Asp Leu Val Phe 
1               5                   10                  15      


Ala Lys Leu Lys Gly Tyr Ala His Trp Pro Ala Arg Ile Glu Gln Thr 
            20                  25                  30          


Ala Glu Ala Asn Arg Tyr Gln Val Phe Phe Phe Gly Thr His Glu Thr 
        35                  40                  45              


Ala Phe Leu Gly Pro Arg His Leu Phe Pro Tyr Glu Glu Ser Lys Glu 
    50                  55                  60                  


Lys Phe Gly Lys Pro Asn Lys Arg Arg Gly Phe Ser Glu Gly Leu Trp 
65                  70                  75                  80  


Glu Ile Glu Asn Asn Pro Thr Val Gln Ala Ser Asp Tyr Gln Cys Ala 
                85                  90                  95      


Leu Glu Lys Ser Cys Pro Glu Glu Pro Glu Pro Glu Val Ala Glu Gly 
            100                 105                 110         


Gly Glu Asp Pro Lys Ser His Thr Asn Gly Gly Asp Asp Asp Asp Gln 
        115                 120                 125             


Gly Lys Leu Gly Val Asp Leu Pro Ala Glu Glu Glu Asn Lys Lys Glu 
    130                 135                 140                 


Thr Leu Lys Arg Thr Ala Glu Asp Pro Pro Glu Asp Ile Pro Lys Arg 
145                 150                 155                 160 


Pro Lys Glu Ala Asp Pro Glu Glu Gly Glu Glu Arg Lys Glu Ala Ala 
                165                 170                 175     


Ala Val Ala Glu Glu Ala Glu Asp Ala Arg Pro Leu Leu Val Glu Val 
            180                 185                 190         


Glu Asn Asp Pro Ala Ala Ser Val Leu Gly Leu Ala Trp Gly Leu Pro 
        195                 200                 205             


Val Met Glu Gln Glu Pro Glu Glu Glu Ser Ala Glu Arg Glu Ala Gln 
    210                 215                 220                 


Ala Pro Gly Val Gly Gly Gly His Glu Ser Gln 
225                 230                 235 


<210>  25
<211>  2346
<212>  DNA
<213>  Homo sapiens

<400>  25
gacccccggt ctcgcccccg aaacatgact cgcgatttca aacctggaga cctcatcttc     60

gccaagatga aaggttatcc ccattggcca gctcgagtag acgaagttcc tgatggagct    120

gtaaagccac ccacaaacaa actacccatt ttcttttttg gaactcatga gactgctttt    180

ttaggaccaa aggatatatt tccttactca gaaaataagg aaaagtatgg caaaccaaat    240

aaaagaaaag gttttaatga aggtttatgg gagatagata acaatccaaa agtgaaattt    300

tcaagtcaac aggcagcaac taaacaatca aatgcatcat ctgatgttga agttgaagaa    360

aaggaaacta gtgtttcaaa ggaagatacc gaccatgaag aaaaagccag caatgaggat    420

gtgactaaag cagttgacat aactactcca aaagctgcca gaagggggag aaagagaaag    480

gcagaaaaac aagtagaaac tgaggaggca ggagtagtga caacagcaac agcatctgtt    540

aatctaaaag tgagtcctaa aagaggacga cctgcagcta cagaagtcaa gattccaaaa    600

ccaagaggca gacccaaaat ggtaaaacag ccctgtcctt cagagagtga catcattact    660

gaagaggaca aaagtaagaa aaaggggcaa gagggaaaac aacctaaaaa gcagcctaag    720

aaggatgaag agggccagaa ggaagaagat aagccaagaa aagagccgga taaaaaagag    780

gggaagaaag aagttgaatc aaaaaggaaa aatttagcta aaacaggggt tacttcaacc    840

tccgattctg aagaagaagg agatgatcaa gaaggtgaaa agaagagaaa aggtgggagg    900

aactttcaga ctgctcacag aaggaatatg ctgaaaggcc aacatgagaa agaagcagca    960

gatcgaaaac gcaagcaaga ggaacaaatg gaaactgagc agcagaataa agatgaagga   1020

aagaagccag aagttaagaa agtggagaag aagcgagaaa catcaatgga ttctcgactt   1080

caaaggatac atgctgagat taaaaattca ctcaaaattg ataatcttga tgtgaacaga   1140

tgcattgagg ccttggatga acttgcttca cttcaggtca caatgcaaca agctcagaaa   1200

cacacagaga tgattactac actgaaaaaa atacggcgat tcaaagttag tcaggtaatc   1260

atggaaaagt ctacaatgtt gtttaacaag tttaagaaca tgttcttggt tggtgaagga   1320

gattccgtga tcacccaagt gctgaataaa tctcttgctg aacaaagaca gcatgaggaa   1380

gcgaataaaa ccaaagatca agggaagaaa gggccaaaca aaaagctaga gaaggaacaa   1440

acagggtcaa agactctaaa tggaggatct gatgctcaag atggtaatca gccacaacat   1500

aacggggaga gcaatgaaga cagcaaagac aaccatgaag ccagcacgaa gaaaaagcca   1560

tccagtgaag agagagagac tgaaatatct ctgaaggatt ctacactaga taactaggtt   1620

gacatacctg gaatatagag aacacttgag aagtttgtaa tggttttcat ttgaaataga   1680

ctgctgaaag ttttaaattt ttataagcat aggtttgatg ttgaaaactt gttttgaggg   1740

agaaaatccc tttgttttaa agtaaagtaa acattatcgc taagtgtact tgtgcagtat   1800

taacagctac attatacagt aaatgtggga tggaatccat ttaggaaatg ttaaactgct   1860

tttccagaca tggttgtagc atattttcaa ttagtgtgtg tatgttaatg tgtaattgat   1920

agtagaacaa agttacattt ttaaaactgc tacttgtata aaccttgcct cttttcccaa   1980

atactgtggg ttttgtgcat agtttttaca aaccttggat ttaccagact gtcttttcac   2040

tgtttgtggg ttttgtagaa gttacacatt tttatggtag ataaaatgtt acttctatac   2100

aagtactcac tcccttttta tcaaaagtta attttaatct cacagtctac attgtgctac   2160

attatccagc ttctttggaa caatgtgtgc tctgtatggt tttttttggt atgacaacta   2220

attaagcaac tgacattgaa ctgagaattc tacaaactat aaaacattaa tttttgaagg   2280

taatttagtt ttgtggctgg gcattcagtg aagtcttagg acttctttgc agacaactga   2340

ctgggt                                                              2346


<210>  26
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Thr Arg Asp Phe Lys Pro Gly Asp Leu Ile Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Val Asp Glu Val Pro Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Thr Asn Lys Leu Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Ile Phe Pro Tyr Ser Glu Asn 
    50                  55                  60                  


Lys Glu Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Asp Asn Asn Pro Lys Val Lys Phe Ser Ser Gln Gln 
                85                  90                  95      


Ala Ala Thr Lys Gln Ser Asn Ala Ser Ser Asp Val Glu Val Glu Glu 
            100                 105                 110         


Lys Glu Thr Ser Val Ser Lys Glu Asp Thr Asp His Glu Glu Lys Ala 
        115                 120                 125             


Ser Asn Glu Asp Val Thr Lys Ala Val Asp Ile Thr Thr Pro Lys Ala 
    130                 135                 140                 


Ala Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln Val Glu Thr Glu 
145                 150                 155                 160 


Glu Ala Gly Val Val Thr Thr Ala Thr Ala Ser Val Asn Leu Lys Val 
                165                 170                 175     


Ser Pro Lys Arg Gly Arg Pro Ala Ala Thr Glu Val Lys Ile Pro Lys 
            180                 185                 190         


Pro Arg Gly Arg Pro Lys Met Val Lys Gln Pro Cys Pro Ser Glu Ser 
        195                 200                 205             


Asp Ile Ile Thr Glu Glu Asp Lys Ser Lys Lys Lys Gly Gln Glu Gly 
    210                 215                 220                 


Lys Gln Pro Lys Lys Gln Pro Lys Lys Asp Glu Glu Gly Gln Lys Glu 
225                 230                 235                 240 


Glu Asp Lys Pro Arg Lys Glu Pro Asp Lys Lys Glu Gly Lys Lys Glu 
                245                 250                 255     


Val Glu Ser Lys Arg Lys Asn Leu Ala Lys Thr Gly Val Thr Ser Thr 
            260                 265                 270         


Ser Asp Ser Glu Glu Glu Gly Asp Asp Gln Glu Gly Glu Lys Lys Arg 
        275                 280                 285             


Lys Gly Gly Arg Asn Phe Gln Thr Ala His Arg Arg Asn Met Leu Lys 
    290                 295                 300                 


Gly Gln His Glu Lys Glu Ala Ala Asp Arg Lys Arg Lys Gln Glu Glu 
305                 310                 315                 320 


Gln Met Glu Thr Glu Gln Gln Asn Lys Asp Glu Gly Lys Lys Pro Glu 
                325                 330                 335     


Val Lys Lys Val Glu Lys Lys Arg Glu Thr Ser Met Asp Ser Arg Leu 
            340                 345                 350         


Gln Arg Ile His Ala Glu Ile Lys Asn Ser Leu Lys Ile Asp Asn Leu 
        355                 360                 365             


Asp Val Asn Arg Cys Ile Glu Ala Leu Asp Glu Leu Ala Ser Leu Gln 
    370                 375                 380                 


Val Thr Met Gln Gln Ala Gln Lys His Thr Glu Met Ile Thr Thr Leu 
385                 390                 395                 400 


Lys Lys Ile Arg Arg Phe Lys Val Ser Gln Val Ile Met Glu Lys Ser 
                405                 410                 415     


Thr Met Leu Phe Asn Lys Phe Lys Asn Met Phe Leu Val Gly Glu Gly 
            420                 425                 430         


Asp Ser Val Ile Thr Gln Val Leu Asn Lys Ser Leu Ala Glu Gln Arg 
        435                 440                 445             


Gln His Glu Glu Ala Asn Lys Thr Lys Asp Gln Gly Lys Lys Gly Pro 
    450                 455                 460                 


Asn Lys Lys Leu Glu Lys Glu Gln Thr Gly Ser Lys Thr Leu Asn Gly 
465                 470                 475                 480 


Gly Ser Asp Ala Gln Asp Gly Asn Gln Pro Gln His Asn Gly Glu Ser 
                485                 490                 495     


Asn Glu Asp Ser Lys Asp Asn His Glu Ala Ser Thr Lys Lys Lys Pro 
            500                 505                 510         


Ser Ser Glu Glu Arg Glu Thr Glu Ile Ser Leu Lys Asp Ser Thr Leu 
        515                 520                 525             


Asp Asn 
    530 


<210>  27
<211>  528
<212>  PRT
<213>  Mus musculus

<400>  27

Met Thr Arg Asp Phe Lys Pro Gly Asp Leu Ile Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Val Asp Glu Val Pro Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Thr Asn Lys Leu Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Ile Phe Pro Tyr Ser Glu Asn 
    50                  55                  60                  


Lys Glu Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Asp Asn Asn Pro Lys Val Lys Phe Ser Ser Gln Gln 
                85                  90                  95      


Ala Ser Thr Lys Gln Ser Asn Ala Ser Ser Asp Val Glu Val Glu Glu 
            100                 105                 110         


Lys Glu Thr Asn Val Ser Lys Glu Asp Thr Asp Gln Glu Glu Lys Ala 
        115                 120                 125             


Ser Asn Glu Asp Val Thr Lys Ala Val Asp Ile Thr Thr Pro Lys Ala 
    130                 135                 140                 


Ala Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln Val Asp Thr Glu 
145                 150                 155                 160 


Glu Ala Gly Met Val Thr Ala Ala Thr Ala Ser Asn Val Lys Ala Ser 
                165                 170                 175     


Pro Lys Arg Gly Arg Pro Ala Ala Thr Glu Val Lys Ile Pro Lys Pro 
            180                 185                 190         


Arg Gly Arg Pro Lys Val Val Lys Gln Pro Cys Pro Ser Asp Gly Asp 
        195                 200                 205             


Met Val Ile Asp Glu Asp Lys Ser Lys Lys Lys Gly Pro Glu Glu Lys 
    210                 215                 220                 


Gln Pro Lys Lys Gln Leu Lys Lys Glu Glu Glu Gly Gln Lys Glu Glu 
225                 230                 235                 240 


Glu Lys Pro Arg Lys Glu Pro Asp Lys Lys Glu Gly Lys Lys Glu Val 
                245                 250                 255     


Glu Ser Lys Arg Lys Asn Leu Ala Lys Pro Gly Val Thr Ser Thr Ser 
            260                 265                 270         


Asp Ser Glu Asp Glu Asp Asp Gln Glu Gly Glu Lys Lys Arg Lys Gly 
        275                 280                 285             


Gly Arg Asn Phe Gln Ala Ala His Arg Arg Asn Met Leu Lys Gly Gln 
    290                 295                 300                 


His Glu Lys Glu Ala Gly Asp Arg Lys Arg Lys Gln Glu Glu Gln Met 
305                 310                 315                 320 


Glu Thr Glu Gln Gln Asn Lys Asp Glu Gly Lys Lys Pro Glu Val Lys 
                325                 330                 335     


Lys Val Glu Lys Lys Arg Glu Thr Ser Met Asp Ser Arg Leu Gln Arg 
            340                 345                 350         


Ile His Ala Glu Ile Lys Asn Ser Leu Lys Ile Asp Asn Leu Asp Val 
        355                 360                 365             


Asn Arg Cys Ile Glu Ala Leu Asp Glu Leu Ala Ser Leu Gln Val Thr 
    370                 375                 380                 


Met Gln Gln Ala Gln Lys His Thr Glu Met Ile Thr Thr Leu Lys Lys 
385                 390                 395                 400 


Ile Arg Arg Phe Lys Val Ser Gln Val Ile Met Glu Lys Ser Thr Met 
                405                 410                 415     


Leu Tyr Asn Lys Phe Lys Asn Met Phe Leu Val Gly Glu Gly Asp Ser 
            420                 425                 430         


Val Ile Thr Gln Val Leu Asn Lys Ser Leu Ala Glu Gln Arg Gln His 
        435                 440                 445             


Glu Glu Ala Asn Lys Thr Lys Asp Gln Gly Lys Lys Gly Pro Asn Lys 
    450                 455                 460                 


Lys Leu Glu Lys Glu Pro Thr Gly Thr Lys Ser Leu Asn Gly Gly Ser 
465                 470                 475                 480 


Asp Ala Gln Glu Ser Asn His Pro Gln His Asn Gly Asp Ser Asn Glu 
                485                 490                 495     


Asp Gly Lys Asp Ser Arg Glu Ala Ser Ser Lys Thr Lys Pro Pro Gly 
            500                 505                 510         


Glu Glu Arg Glu Ala Glu Ile Ser Leu Lys Glu Ser Thr Leu Asp Asn 
        515                 520                 525             


<210>  28
<211>  528
<212>  PRT
<213>  Rattus norvegicus

<400>  28

Met Thr Arg Asp Phe Lys Pro Gly Asp Leu Ile Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Val Asp Glu Val Pro Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Thr Asn Lys Leu Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Ile Phe Pro Tyr Ser Glu Asn 
    50                  55                  60                  


Lys Glu Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Asp Asn Asn Pro Lys Val Lys Phe Ser Ser Gln Gln 
                85                  90                  95      


Val Ser Thr Lys Gln Ser Asn Ala Ser Ser Asp Val Glu Ala Glu Glu 
            100                 105                 110         


Lys Glu Thr Ser Val Ser Lys Glu Asp Thr Asp Gln Glu Glu Lys Ala 
        115                 120                 125             


Ser Asn Glu Asp Val Thr Lys Ala Ala Asp Ile Thr Thr Pro Lys Ala 
    130                 135                 140                 


Ala Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln Val Asp Thr Glu 
145                 150                 155                 160 


Glu Ala Gly Val Val Thr Ala Ala Thr Ala Ser Asn Val Lys Ala Ser 
                165                 170                 175     


Pro Lys Arg Gly Arg Pro Ala Ala Thr Glu Val Lys Ile Pro Lys Pro 
            180                 185                 190         


Arg Gly Arg Pro Lys Val Val Lys Gln Pro Cys Pro Ser Glu Ser Asp 
        195                 200                 205             


Met Val Ile Asp Glu Asp Lys Ser Lys Lys Lys Gly Pro Glu Glu Lys 
    210                 215                 220                 


Pro Pro Lys Lys Gln Leu Lys Lys Glu Glu Glu Gly Gln Lys Glu Glu 
225                 230                 235                 240 


Glu Lys Pro Arg Lys Glu Pro Asp Lys Lys Glu Gly Lys Lys Glu Val 
                245                 250                 255     


Glu Ser Lys Arg Lys Asn Leu Ala Lys Pro Gly Val Thr Ser Thr Ser 
            260                 265                 270         


Asp Ser Glu Glu Asp Asp Asp Gln Glu Gly Glu Lys Lys Arg Lys Gly 
        275                 280                 285             


Gly Arg His Phe Gln Ala Ala His Arg Arg Asn Met Leu Lys Gly Gln 
    290                 295                 300                 


His Glu Lys Glu Ala Ala Asp Arg Lys Arg Lys Gln Glu Glu Gln Met 
305                 310                 315                 320 


Glu Thr Glu Gln Gln Thr Lys Asp Glu Gly Lys Lys Pro Glu Val Lys 
                325                 330                 335     


Lys Val Glu Lys Lys Arg Glu Thr Ser Met Asp Ser Arg Leu Gln Arg 
            340                 345                 350         


Ile His Ala Glu Ile Lys Asn Ser Leu Lys Ile Asp Asn Leu Asp Val 
        355                 360                 365             


Asn Arg Cys Ile Glu Ala Leu Asp Glu Leu Ala Ser Leu Gln Val Thr 
    370                 375                 380                 


Met Gln Gln Ala Gln Lys His Thr Glu Met Ile Thr Thr Leu Lys Lys 
385                 390                 395                 400 


Ile Arg Arg Phe Lys Val Ser Gln Val Ile Met Glu Lys Ser Thr Met 
                405                 410                 415     


Leu Tyr Asn Lys Phe Lys Asn Met Phe Leu Val Gly Glu Gly Asp Ser 
            420                 425                 430         


Val Ile Thr Gln Val Leu Asn Lys Ser Leu Ala Glu Gln Arg Gln His 
        435                 440                 445             


Glu Glu Ala Asn Lys Thr Lys Asp Gln Gly Lys Lys Gly Pro Asn Lys 
    450                 455                 460                 


Lys Leu Glu Lys Glu Gln Thr Gly Thr Lys Ser Leu Asn Gly Gly Ser 
465                 470                 475                 480 


Asp Ala Gln Glu Ser Asn His Pro Gln His Asn Gly Asp Ser Ala Glu 
                485                 490                 495     


Glu Ser Lys Asp Ser Arg Glu Ala Gly Ser Lys Thr Lys Thr Pro Gly 
            500                 505                 510         


Glu Glu Arg Glu Ala Glu Val Ser Leu Lys Glu Ser Thr Leu Asp Asn 
        515                 520                 525             


<210>  29
<211>  483
<212>  PRT
<213>  Bos taurus

<400>  29

His Glu Thr Ala Phe Leu Gly Pro Lys Asp Ile Phe Pro Tyr Ser Glu 
1               5                   10                  15      


Asn Lys Glu Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu 
            20                  25                  30          


Gly Leu Trp Glu Ile Asp Asn Asn Pro Lys Val Lys Phe Ser Ser Gln 
        35                  40                  45              


Gln Ala Ser Ala Lys Gln Ser Asn Ala Ser Ser Asp Val Glu Val Glu 
    50                  55                  60                  


Glu Lys Glu Thr Ser Val Ser Lys Glu Asp Thr Asp Pro Glu Glu Lys 
65                  70                  75                  80  


Ala Ser Asn Glu Asp Val Thr Lys Ala Ile Asp Ile Thr Thr Pro Lys 
                85                  90                  95      


Ala Ala Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln Val Glu Thr 
            100                 105                 110         


Glu Glu Ala Gly Val Val Thr Thr Ala Thr Ala Ser Ala Asn Leu Lys 
        115                 120                 125             


Val Ser Pro Lys Arg Gly Arg Pro Ala Ala Thr Glu Val Lys Ile Pro 
    130                 135                 140                 


Lys Pro Arg Gly Arg Pro Lys Met Val Lys Gln Pro Cys Pro Ser Glu 
145                 150                 155                 160 


Ser Asp Met Ile Thr Glu Glu Asp Lys Ser Lys Lys Lys Gly Gln Glu 
                165                 170                 175     


Glu Lys Gln Pro Lys Lys Gln Leu Lys Lys Asp Glu Glu Gly Gln Lys 
            180                 185                 190         


Glu Glu Glu Lys Pro Arg Lys Glu Pro Asp Lys Lys Glu Gly Lys Lys 
        195                 200                 205             


Glu Val Glu Ser Lys Arg Lys Asn Leu Ala Lys Thr Gly Val Thr Ser 
    210                 215                 220                 


Thr Ser Asp Ser Glu Glu Glu Gly Asp Asp Gln Glu Gly Glu Lys Lys 
225                 230                 235                 240 


Arg Lys Gly Gly Arg Asn Phe Gln Thr Ala His Arg Arg Asn Met Leu 
                245                 250                 255     


Lys Gly Gln His Glu Lys Glu Ala Ala Asp Arg Lys Arg Lys Gln Glu 
            260                 265                 270         


Glu Gln Met Glu Thr Glu Gln Gln Asn Lys Asp Glu Gly Lys Lys Pro 
        275                 280                 285             


Glu Val Lys Lys Val Glu Lys Lys Arg Glu Thr Ser Met Asp Ser Arg 
    290                 295                 300                 


Leu Gln Arg Ile His Ala Glu Ile Lys Asn Ser Leu Lys Ile Asp Asn 
305                 310                 315                 320 


Leu Asp Val Asn Arg Cys Ile Glu Ala Leu Asp Glu Leu Ala Ser Leu 
                325                 330                 335     


Gln Val Thr Met Gln Gln Ala Gln Lys His Thr Glu Met Ile Thr Thr 
            340                 345                 350         


Leu Lys Lys Ile Arg Arg Phe Lys Val Ser Gln Val Ile Met Glu Lys 
        355                 360                 365             


Ser Thr Met Leu Tyr Asn Lys Phe Lys Asn Met Phe Leu Val Gly Glu 
    370                 375                 380                 


Gly Asp Ser Val Ile Thr Gln Val Leu Asn Lys Ser Leu Ala Glu Gln 
385                 390                 395                 400 


Arg Gln His Glu Glu Ala Asn Lys Thr Lys Asp Gln Gly Lys Lys Gly 
                405                 410                 415     


Pro Asn Lys Lys Leu Glu Lys Glu Gln Thr Gly Ser Lys Thr Leu Asn 
            420                 425                 430         


Gly Gly Ser Asp Ala Gln Asp Ser Asn Gln Pro Gln His Asn Gly Asp 
        435                 440                 445             


Ser Asn Glu Glu Ser Lys Asp Asn His Glu Ala Ser Ser Lys Lys Lys 
    450                 455                 460                 


Pro Ser Ser Glu Glu Arg Glu Thr Glu Ile Ser Leu Lys Asp Ser Thr 
465                 470                 475                 480 


Leu Asp Asn 
            


<210>  30
<211>  579
<212>  PRT
<213>  gallus gallus

<400>  30

Met Ser Arg Asp Phe Lys Pro Gly Asp Leu Ile Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Val Asp Glu Val Pro Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Thr Asn Lys Met Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Ile Phe Pro Tyr Ser Glu Asn 
    50                  55                  60                  


Lys Asp Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Asp Asn Asn Pro Lys Val Lys Phe Ser His Gln Pro 
                85                  90                  95      


Ser His Pro Ala Val Asn Thr Ser Ile Lys Glu Thr Ile Gln Glu Ser 
            100                 105                 110         


Ser Pro Glu Ala Ala Glu Gly Ser Glu Glu Lys Ser Gly Ala Lys Arg 
        115                 120                 125             


Arg Lys Pro Ser Ile Pro Lys Leu Pro Pro Lys Gly Asp Asn Asn Ser 
    130                 135                 140                 


Pro Ala Glu Ala Glu Ala Glu Glu Lys Glu Met His Ser Thr Lys Glu 
145                 150                 155                 160 


Asp Glu Glu Pro Ser Glu Lys Asn Ser Lys Glu Gly Val Val Lys Thr 
                165                 170                 175     


Asn Asp Ala Ser Ile Pro Lys Val Ala Arg Arg Gly Arg Lys Arg Lys 
            180                 185                 190         


Ala Glu Lys Gln Ala Glu Ser Glu Glu Ala Ala Val Val Ala Thr Ala 
        195                 200                 205             


Ala Val Val Ala Ala Ala Ala Ala Pro Val Thr Val Ser Pro Lys Val 
    210                 215                 220                 


Ser Pro Lys Arg Gly Arg Pro Ala Val Ser Glu Val Lys Val Pro Lys 
225                 230                 235                 240 


Pro Arg Gly Arg Pro Lys Leu Val Lys Pro Ser Cys Leu Ser Glu Ser 
                245                 250                 255     


Asp Pro Val Asn Glu Glu Glu Lys Ala Lys Lys Lys Gly Pro Asp Glu 
            260                 265                 270         


Lys Pro Lys Lys Gln Gly Lys Lys Asp Glu Glu Gly Gln Lys Glu Glu 
        275                 280                 285             


Glu Lys Pro Lys Lys Glu Tyr Asp Lys Lys Asp Gly Lys Lys Glu Ala 
    290                 295                 300                 


Glu Pro Lys Arg Lys Asn Ala Ala Lys Leu Gly Ser Ala Ser Ala Ser 
305                 310                 315                 320 


Asp Ser Glu Asp Glu Gly Gly Glu Glu Glu Gly Asp Lys Lys Lys Lys 
                325                 330                 335     


Gly Gly Arg Ser Phe Gln Ser Thr His Arg Arg Asn Ile Met Arg Gly 
            340                 345                 350         


Gln His Glu Lys Glu Val Thr Glu Arg Lys Arg Lys Gln Glu Glu Gln 
        355                 360                 365             


Gly Glu Ser Glu Leu Gln Asn Lys Glu Glu Gly Lys Lys Thr Glu Val 
    370                 375                 380                 


Lys Lys Met Glu Lys Lys Arg Glu Thr Ser Met Asp Ser Arg Leu Gln 
385                 390                 395                 400 


Arg Ile His Ala Glu Ile Lys Asn Ser Leu Lys Ile Asp Asn Leu Asp 
                405                 410                 415     


Val Asn Arg Cys Ile Glu Ala Leu Asp Glu Leu Ala Ser Leu Gln Val 
            420                 425                 430         


Ser Met Gln Gln Ala Gln Lys His Thr Glu Met Ile Leu Thr Leu Lys 
        435                 440                 445             


Lys Ile Arg Lys Phe Lys Val Ser Gln Val Ile Met Glu Lys Ser Thr 
    450                 455                 460                 


Met Leu Tyr Asn Lys Phe Lys Thr Met Phe Leu Val Gly Glu Gly Asp 
465                 470                 475                 480 


Ser Val Leu Ser Gln Val Leu Asn Lys Ser Leu Ala Glu Gln Lys Gln 
                485                 490                 495     


His Glu Glu Ala Asn Lys Thr Lys Glu Gln Trp Lys Lys Gly Thr Asn 
            500                 505                 510         


Lys Lys Asn Glu Lys Glu Lys Asp Gln Thr Gly Ser Lys Ile Val Asn 
        515                 520                 525             


Gly Gly Ser Glu Thr Gln Asp Thr Asn Gln Ser Gln His Asn Gly Glu 
    530                 535                 540                 


Asn Ala Glu Glu Lys Asp Lys Leu Glu Val Ala Ser Lys Lys Lys Thr 
545                 550                 555                 560 


Cys Gly Glu Glu Ser Glu Leu Glu Lys Pro Ala Lys Glu Ser Ala Phe 
                565                 570                 575     


Glu Asn Lys 
            




<210>  31
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  C1 heavy chain nt

<400>  31
gaggtgcagc ttgttgagtc tggtggaaga ttggtgcagc ctaaagggtc attgaaactc     60

tcatgtgcag cctctggatt caccttcaat acctatgcca tgtactggat ccgccaggct    120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagttataa ttatgcaaca    180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc acaaagcatg    240

ctctatctgc aaatgaacaa cctgaaaact gcggacacag ccatgtatta ctgtgtgagt    300

gagggatttt ggggtcaagg aacctcagtc accgtctcct ca                       342


<210>  32
<211>  114
<212>  PRT
<213>  Artificial


<220>
<223>  C1 heavy chain aa


<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Tyr Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Ala Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Ser Glu Gly Phe Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  33
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  C1 light chain nt

<400>  33
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc     60

atctcttgca gatctagtca gagcattgta catagtagtg gaaacaccta tttagaatgg    120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt    180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc    240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg    300

tggacgttcg gtggaggcac caagctggaa atcaaa                              336


<210>  34
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  C1 light chain aa

<400>  34

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Ser Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  35
<211>  360
<212>  DNA
<213>  artificial

<220>
<223>  H3 heavy chain nt

<400>  35
cagattactc tgaaacagtc tggccctggg atagtgcagc catcccagcc cgtcagactt     60

acttgcactt tctctgggtt ttcactgagc acttctggta taggtgtagc ctggattcgt    120

cagccctcag ggaagggtct ggagtggctg gcaaccattt ggtgggatga tgataaccgc    180

tacaacccat ctctaaagag caggctcgca gtctccaaag acacctccaa caaccaagca    240

ttcctgaata tcatcactgt ggaaactgca gatactgcca tatactactg tgctcagatc    300

tatgattacg ccgtgggttt tgcttattgg ggccaaggga ctctggtcac tgtctctgca    360


<210>  36
<211>  120
<212>  PRT
<213>  artificial

<220>
<223>  H3 heavy chain aa

<400>  36

Gln Ile Thr Leu Lys Gln Ser Gly Pro Gly Ile Val Gln Pro Ser Gln 
1               5                   10                  15      


Pro Val Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Ile Gly Val Ala Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Thr Ile Trp Trp Asp Asp Asp Asn Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Ala Val Ser Lys Asp Thr Ser Asn Asn Gln Ala 
65                  70                  75                  80  


Phe Leu Asn Ile Ile Thr Val Glu Thr Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Gln Ile Tyr Asp Tyr Ala Val Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 



<210>  37
<211>  318
<212>  DNA
<213>  artificial

<220>
<223>  H3 light chain nt

<400>  37
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggatattagc aattatttaa actggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct    240

gacgatattg ccacttacta ttgtcaacaa tatggtaagt tgtggacgtt cggtggaggc    300

accaagctgg aaatcaaa                                                  318


<210>  38
<211>  106
<212>  PRT
<213>  artificial

<220>
<223>  H3 light chain aa

<400>  38

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Lys Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  39
<211>  399
<212>  DNA
<213>  artificial 

<220>
<223>  C1 heavy chain nt

<400>  39
atggtgatgg ggctgaagtg ggttttcttt gctgtttttt atcaaggtgt gcattgtgag     60

gtgcagcttg ttgagtctgg tggaagattg gtgcagccta aagggtcatt gaaactctca    120

tgtgcagcct ctggattcac cttcaatacc tatgccatgt actggatccg ccaggctcca    180

ggaaagggtt tggaatgggt tgctcgcata agaagtaaaa gttataatta tgcaacatat    240

tatgccgatt cagtgaaaga cagattcacc atctccagag atgattcaca aagcatgctc    300

tatctgcaaa tgaacaacct gaaaactgcg gacacagcca tgtattactg tgtgagtgag    360

ggattttggg gtcaaggaac ctcagtcacc gtctcctca                           399


<210>  40
<211>  133
<212>  PRT
<213>  artificial

<220>
<223>  C1 heavy chain aa

<400>  40

Met Val Met Gly Leu Lys Trp Val Phe Phe Ala Val Phe Tyr Gln Gly 
1               5                   10                  15      


Val His Cys Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln 
            20                  25                  30          


Pro Lys Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Thr Tyr Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Tyr Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Gln Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Ala Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Val Ser Glu Gly Phe Trp Gly Gln Gly Thr Ser 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  41
<211>  393
<212>  DNA
<213>  Artificial

<220>
<223>  C1 light chain nt

<400>  41
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat     60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc    120

tcttgcagat ctagtcagag cattgtacat agtagtggaa acacctattt agaatggtac    180

ctgcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct    240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc    300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttccgtgg    360

acgttcggtg gaggcaccaa gctggaaatc aaa                                 393


<210>  42
<211>  131
<212>  PRT
<213>  Artificial

<220>
<223>  C1 light chain aa

<400>  42

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              


Val His Ser Ser Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     



<210>  43
<211>  417
<212>  DNA
<213>  artifical

<220>
<223>  H3 heavy chain nt

<400>  43
atggacaggc ttatgtcttc attcctgctg ctggttgtcc ctatatatgt tctgtcccag     60

attactctga aacagtctgg ccctgggata gtgcagccat cccagcccgt cagacttact    120

tgcactttct ctgggttttc actgagcact tctggtatag gtgtagcctg gattcgtcag    180

ccctcaggga agggtctgga gtggctggca accatttggt gggatgatga taaccgctac    240

aacccatctc taaagagcag gctcgcagtc tccaaagaca cctccaacaa ccaagcattc    300

ctgaatatca tcactgtgga aactgcagat actgccatat actactgtgc tcagatctat    360

gattacgccg tgggttttgc ttattggggc caagggactc tggtcactgt ctctgca       417



<210>  44
<211>  139
<212>  PRT
<213>  artificial

<220>
<223>  H3 heavy chain aa

<400>  44

Met Asp Arg Leu Met Ser Ser Phe Leu Leu Leu Val Val Pro Ile Tyr 
1               5                   10                  15      


Val Leu Ser Gln Ile Thr Leu Lys Gln Ser Gly Pro Gly Ile Val Gln 
            20                  25                  30          


Pro Ser Gln Pro Val Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Ile Gly Val Ala Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala Thr Ile Trp Trp Asp Asp Asp Asn Arg Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Leu Ala Val Ser Lys Asp Thr Ser Asn 
                85                  90                  95      


Asn Gln Ala Phe Leu Asn Ile Ile Thr Val Glu Thr Ala Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Ala Gln Ile Tyr Asp Tyr Ala Val Gly Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 



<210>  45
<211>  378
<212>  DNA
<213>  artificial

<220>
<223>  H3 light chain nt

<400>  45
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt     60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc    120

atcagttgca gggcaagtca ggatattagc aattatttaa actggtatca gcagaaacca    180

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca    240

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct    300

gacgatattg ccacttacta ttgtcaacaa tatggtaagt tgtggacgtt cggtggaggc    360

accaagctgg aaatcaaa                                                  378


<210>  46
<211>  126
<212>  PRT
<213>  artificial

<<220>
<223>  H3 light chain aa

<400>  46

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly 
            100                 105                 110         


Lys Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  47
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA-1

<400>  47
aaccggcaga aggaguacaa a                                               21


<210>  48
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA-2

<400>  48
aaaucaacag ccaacaaaua c                                               21
       

