
             39766-0160-R4 PCT Saved October 10, 2007.txt                             
                        SEQUENCE LISTING

<110> Genentech, Inc.
      DENNIS, Mark S.
      RUBINFELD, Bonnee
      POLAKIS, Paul
      JAKOBOVITS, Aya

<120> ANTIBODIES AND IMMUNOCONJUGATES AND USES
  THEREFOR

<130> 39766-0160-R4.PCT

<140> Not yet Assigned    
<141> Herewith           

<150> 60/863,295          
<151> 2006-10-27  

<150> 60/868,707          
<151> 2006-12-05  

<150> 60/921,300          
<151> 2007-03-30  

<150> 60/937,857          
<151> 2007-06-29  

<160> 89

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 340
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Ser Arg Lys Asp Ile Thr Asn Gln Glu Glu Leu Trp Lys Met
 1               5                  10                  15      
Lys Pro Arg Arg Asn Leu Glu Glu Asp Asp Tyr Leu His Lys Asp Thr
            20                  25                  30          
Gly Glu Thr Ser Met Leu Lys Arg Pro Val Leu Leu His Leu His Gln
        35                  40                  45              
Thr Ala His Ala Asp Glu Phe Asp Cys Pro Ser Glu Leu Gln His Thr
    50                  55                  60                  
Gln Glu Leu Phe Pro Gln Trp His Leu Pro Ile Lys Ile Ala Ala Ile
65                  70                  75                  80  
Ile Ala Ser Leu Thr Phe Leu Tyr Thr Leu Leu Arg Glu Val Ile His
                85                  90                  95      
Pro Leu Ala Thr Ser His Gln Gln Tyr Phe Tyr Lys Ile Pro Ile Leu
            100                 105                 110         
Val Ile Asn Lys Val Leu Pro Met Val Ser Ile Thr Leu Leu Ala Leu
        115                 120                 125             
Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Val Gln Leu His Asn Gly
    130                 135                 140                 
Thr Lys Tyr Lys Lys Phe Pro His Trp Leu Asp Lys Trp Met Leu Thr
145                 150                 155                 160 
Arg Lys Gln Phe Gly Leu Leu Ser Phe Phe Phe Ala Val Leu His Ala
                165                 170                 175     
Ile Tyr Ser Leu Ser Tyr Pro Met Arg Arg Ser Tyr Arg Tyr Lys Leu
            180                 185                 190         
Leu Asn Trp Ala Tyr Gln Gln Val Gln Gln Asn Lys Glu Asp Ala Trp
        195                 200                 205             
Ile Glu His Asp Val Trp Arg Met Glu Ile Tyr Val Ser Leu Gly Ile
    210                 215                 220                 
Val Gly Leu Ala Ile Leu Ala Leu Leu Ala Val Thr Ser Ile Pro Ser
225                 230                 235                 240 
Val Ser Asp Ser Leu Thr Trp Arg Glu Phe His Tyr Ile Gln Ser Lys
                245                 250                 255     
Leu Gly Ile Val Ser Leu Leu Leu Gly Thr Ile His Ala Leu Ile Phe
            260                 265                 270         
Ala Trp Asn Lys Trp Ile Asp Ile Lys Gln Phe Val Trp Tyr Thr Pro
        275                 280                 285             
Pro Thr Phe Met Ile Ala Val Phe Leu Pro Ile Val Val Leu Ile Phe
    290                 295                 300                 
Lys Ser Ile Leu Phe Leu Pro Cys Leu Arg Lys Lys Ile Leu Lys Ile
305                 310                 315                 320 
Arg His Gly Trp Glu Asp Val Thr Lys Ile Asn Lys Thr Glu Ile Cys
                325                 330                 335     
Ser Gln Leu Asn
            340 


<210> 2
<211> 340
<212> PRT
<213> Mus musculus

<400> 2
Met Glu Ile Ser Asp Asp Val Thr Asn Pro Glu Gln Leu Trp Lys Met
 1               5                  10                  15      
Lys Pro Lys Gly Asn Leu Glu Asp Asp Ser Tyr Ser Thr Lys Asp Ser
            20                  25                  30          
Gly Glu Thr Ser Met Leu Lys Arg Pro Gly Leu Ser His Leu Gln His
        35                  40                  45              
Ala Val His Val Asp Ala Phe Asp Cys Pro Ser Glu Leu Gln His Thr
    50                  55                  60                  
Gln Glu Phe Phe Pro Asn Trp Arg Leu Pro Val Lys Val Ala Ala Ile
65                  70                  75                  80  
Ile Ser Ser Leu Thr Phe Leu Tyr Thr Leu Leu Arg Glu Ile Ile Tyr
                85                  90                  95      
Pro Leu Val Thr Ser Arg Glu Gln Tyr Phe Tyr Lys Ile Pro Ile Leu
            100                 105                 110         
Val Ile Asn Lys Val Leu Pro Met Val Ala Ile Thr Leu Leu Ala Leu
        115                 120                 125             
Val Tyr Leu Pro Gly Glu Leu Ala Ala Val Val Gln Leu Arg Asn Gly
    130                 135                 140                 
Thr Lys Tyr Lys Lys Phe Pro Pro Trp Leu Asp Arg Trp Met Leu Ala
145                 150                 155                 160 
Lys Lys Gln Phe Gly Leu Leu Ser Phe Phe Phe Ala Val Leu His Ala
                165                 170                 175     
Val Tyr Ser Leu Ser Tyr Pro Met Arg Arg Ser Tyr Arg Tyr Lys Leu
            180                 185                 190         
Leu Asn Trp Ala Tyr Lys Gln Val Gln Gln Asn Lys Glu Asp Ala Trp
        195                 200                 205             
Val Glu His Asp Val Trp Arg Met Glu Ile Tyr Val Ser Leu Gly Ile
    210                 215                 220                 
Val Gly Leu Ala Ile Leu Ala Leu Leu Ala Val Thr Ser Ile Pro Ser
225                 230                 235                 240 
Val Ser Asp Ser Leu Thr Trp Arg Glu Phe His Tyr Ile Gln Ser Lys
                245                 250                 255     
Leu Gly Ile Val Ser Leu Leu Leu Gly Thr Val His Ala Leu Val Phe
            260                 265                 270         
Ala Trp Asn Lys Trp Val Asp Val Ser Gln Phe Val Trp Tyr Met Pro
        275                 280                 285             
Pro Thr Phe Met Ile Ala Val Phe Leu Pro Thr Leu Val Leu Ile Cys
    290                 295                 300                 
Lys Ile Ala Leu Cys Leu Pro Cys Leu Arg Lys Lys Ile Leu Lys Ile
305                 310                 315                 320 
Arg Cys Gly Trp Glu Asp Val Ser Lys Ile Asn Arg Thr Glu Met Ala
                325                 330                 335     
Ser Arg Leu Asn
            340 


<210> 3
<211> 340
<212> PRT
<213> Macaca fascicularis

<400> 3
Met Glu Ser Arg Lys Asp Ile Thr Asn Glu Glu Glu Leu Trp Lys Met
 1               5                  10                  15      
Lys Pro Arg Arg Asn Leu Glu Glu Asp Asp Tyr Leu His Lys Asp Thr
            20                  25                  30          
Gly Glu Thr Ser Met Leu Lys Arg Pro Val Leu Leu His Leu His Gln
        35                  40                  45              
Thr Ala His Ala Asp Glu Phe Asp Cys Pro Ser Glu Leu Gln His Thr
    50                  55                  60                  
Gln Glu Leu Phe Pro Gln Trp His Leu Pro Ile Lys Ile Ala Ala Ile
65                  70                  75                  80  
Ile Ala Ser Leu Thr Phe Leu Tyr Thr Leu Leu Arg Glu Val Ile His
                85                  90                  95      
Pro Leu Ala Thr Ser His Gln Gln Tyr Phe Tyr Lys Ile Pro Ile Leu
            100                 105                 110         
Val Ile Asn Lys Val Leu Pro Met Val Ser Ile Thr Leu Leu Ala Leu
        115                 120                 125             
Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Val Gln Leu His Asn Gly
    130                 135                 140                 
Thr Lys Tyr Lys Lys Phe Pro His Trp Leu Asp Lys Trp Met Leu Thr
145                 150                 155                 160 
Arg Lys Gln Phe Gly Leu Leu Ser Phe Phe Phe Ala Val Leu His Ala
                165                 170                 175     
Ile Tyr Ser Leu Ser Tyr Pro Met Arg Arg Ser Tyr Arg Tyr Lys Leu
            180                 185                 190         
Leu Asn Trp Ala Tyr Gln Gln Val Gln Gln Asn Lys Glu Asp Ala Trp
        195                 200                 205             
Ile Glu His Asp Val Trp Arg Met Glu Ile Tyr Val Ser Leu Gly Ile
    210                 215                 220                 
Val Gly Leu Ala Ile Leu Ala Leu Leu Ala Val Thr Ser Ile Pro Ser
225                 230                 235                 240 
Val Ser Asp Ser Leu Thr Trp Arg Glu Phe His Tyr Ile Gln Ser Lys
                245                 250                 255     
Leu Gly Ile Val Ser Leu Leu Leu Gly Thr Ile His Ala Leu Ile Phe
            260                 265                 270         
Ala Trp Asn Lys Trp Ile Asp Ile Lys Gln Phe Val Trp Tyr Thr Pro
        275                 280                 285             
Pro Thr Phe Met Ile Ala Val Phe Leu Pro Val Val Val Leu Ile Phe
    290                 295                 300                 
Lys Ser Ile Leu Phe Leu Pro Cys Leu Arg Lys Lys Ile Leu Lys Ile
305                 310                 315                 320 
Arg His Gly Trp Glu Asp Ile Thr Lys Ile Asn Lys Met Glu Ile Ser
                325                 330                 335     
Ser Gln Leu Asn
            340 


<210> 4
<211> 108
<212> PRT
<213> Homo sapiens

<400> 4
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 5
<211> 114
<212> PRT
<213> Mus musculus

<400> 5
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Arg
            20                  25                  30          
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Asn Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
            100                 105                 110         
Lys Arg
        


<210> 6
<211> 114
<212> PRT
<213> Homo sapiens

<400> 6
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Arg
            20                  25                  30          
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys
        35                  40                  45              
Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Asn Tyr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
            100                 105                 110         
Lys Arg
        


<210> 7
<211> 113
<212> PRT
<213> Homo sapiens

<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Val Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser
    


<210> 8
<211> 125
<212> PRT
<213> Mus musculus

<400> 8
Asp Val Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              
Met Gly Tyr Ile Ser Asn Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  
Leu Gln Leu Ile Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Arg Asn Tyr Asp Tyr Asp Asp Tyr Tyr Tyr Ala Met Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ala Ser Ala
        115                 120                 125 


<210> 9
<211> 124
<212> PRT
<213> Homo sapiens

<400> 9
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
        35                  40                  45              
Val Gly Tyr Ile Ser Asn Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Arg Asn Tyr Asp Tyr Asp Asp Tyr Tyr Tyr Ala Met Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 10
<211> 124
<212> PRT
<213> Homo sapiens

<400> 10
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Ser Ile Thr Ser Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
        35                  40                  45              
Val Gly Tyr Ile Ser Asn Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Arg Asn Tyr Asp Tyr Asp Asp Tyr Tyr Tyr Ala Met Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 11
<211> 17
<212> PRT
<213> Homo sapiens

<400> 11
Lys Ser Ser Gln Ser Leu Leu Tyr Arg Ser Asn Gln Lys Asn Tyr Leu
 1               5                  10                  15      
Ala
    


<210> 12
<211> 7
<212> PRT
<213> Homo sapiens

<400> 12
Trp Ala Ser Thr Arg Glu Ser
 1               5          


<210> 13
<211> 9
<212> PRT
<213> Homo sapiens

<400> 13
Gln Gln Tyr Tyr Asn Tyr Pro Arg Thr
 1               5                  


<210> 14
<211> 11
<212> PRT
<213> Homo sapiens

<400> 14
Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn
 1               5                  10      


<210> 15
<211> 17
<212> PRT
<213> Homo sapiens

<400> 15
Gly Tyr Ile Ser Asn Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys
 1               5                  10                  15      
Ser
    


<210> 16
<211> 15
<212> PRT
<213> Homo sapiens

<400> 16
Glu Arg Asn Tyr Asp Tyr Asp Asp Tyr Tyr Tyr Ala Met Asp Tyr
 1               5                  10                  15  


<210> 17
<211> 23
<212> PRT
<213> Homo sapiens

<400> 17
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys
            20              


<210> 18
<211> 15
<212> PRT
<213> Homo sapiens

<400> 18
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 19
<211> 32
<212> PRT
<213> Homo sapiens

<400> 19
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 20
<211> 11
<212> PRT
<213> Homo sapiens

<400> 20
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
 1               5                  10      


<210> 21
<211> 25
<212> PRT
<213> Homo sapiens

<400> 21
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 22
<211> 13
<212> PRT
<213> Homo sapiens

<400> 22
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
 1               5                  10              


<210> 23
<211> 32
<212> PRT
<213> Homo Sapiens

<400> 23
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 24
<211> 11
<212> PRT
<213> Homo Sapiens

<400> 24
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
 1               5                  10      


<210> 25
<211> 25
<212> PRT
<213> Homo Sapiens

<400> 25
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser
            20                  25  


<210> 26
<211> 30
<212> PRT
<213> Homo Sapiens

<400> 26
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
            20                  25                  30  


<210> 27
<211> 14
<212> PRT
<213> Homo Sapiens

<400> 27
Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
 1               5                  10                  


<210> 28
<211> 32
<212> PRT
<213> Homo Sapiens

<400> 28
Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu
 1               5                  10                  15      
Ile Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 29
<211> 11
<212> PRT
<213> Homo Sapiens

<400> 29
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
 1               5                  10      


<210> 30
<211> 25
<212> PRT
<213> Homo Sapiens

<400> 30
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser
            20                  25  


<210> 31
<211> 14
<212> PRT
<213> Homo Sapiens

<400> 31
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
 1               5                  10                  


<210> 32
<211> 31
<212> PRT
<213> Homo Sapiens

<400> 32
Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala
            20                  25                  30      


<210> 33
<211> 30
<212> PRT
<213> Homo Sapiens

<400> 33
Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu
 1               5                  10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 34
<211> 30
<212> PRT
<213> Homo Sapiens

<400> 34
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser
            20                  25                  30  


<210> 35
<211> 14
<212> PRT
<213> Homo Sapiens

<400> 35
Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly
 1               5                  10                  


<210> 36
<211> 32
<212> PRT
<213> Homo Sapiens

<400> 36
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys
 1               5                  10                  15      
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 37
<211> 25
<212> PRT
<213> Homo Sapiens

<400> 37
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser
            20                  25  


<210> 38
<211> 13
<212> PRT
<213> Homo Sapiens

<400> 38
Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
 1               5                  10              


<210> 39
<211> 31
<212> PRT
<213> Homo Sapiens

<400> 39
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys
 1               5                  10                  15      
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
            20                  25                  30      


<210> 40
<211> 30
<212> PRT
<213> Homo Sapiens

<400> 40
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys
 1               5                  10                  15      
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 41
<211> 30
<212> PRT
<213> Homo Sapiens

<400> 41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
            20                  25                  30  


<210> 42
<211> 14
<212> PRT
<213> Homo Sapiens

<400> 42
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
 1               5                  10                  


<210> 43
<211> 32
<212> PRT
<213> Homo Sapiens

<400> 43
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 44
<211> 25
<212> PRT
<213> Homo Sapiens

<400> 44
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 45
<211> 13
<212> PRT
<213> Homo Sapiens

<400> 45
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
 1               5                  10              


<210> 46
<211> 31
<212> PRT
<213> Homo Sapiens

<400> 46
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
            20                  25                  30      


<210> 47
<211> 30
<212> PRT
<213> Homo Sapiens

<400> 47
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 48
<211> 30
<212> PRT
<213> Homo Sapiens

<400> 48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys
            20                  25                  30  


<210> 49
<211> 32
<212> PRT
<213> Homo Sapiens

<400> 49
Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg
            20                  25                  30          


<210> 50
<211> 31
<212> PRT
<213> Homo Sapiens

<400> 50
Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser
            20                  25                  30      


<210> 51
<211> 32
<212> PRT
<213> Homo Sapiens

<400> 51
Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 52
<211> 31
<212> PRT
<213> Homo Sapiens

<400> 52
Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
            20                  25                  30      


<210> 53
<211> 30
<212> PRT
<213> Homo Sapiens

<400> 53
Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
            20                  25                  30  


<210> 54
<211> 23
<212> PRT
<213> Homo Sapiens

<400> 54
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys
            20              


<210> 55
<211> 15
<212> PRT
<213> Homo Sapiens

<400> 55
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 56
<211> 32
<212> PRT
<213> Homo Sapiens

<400> 56
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 57
<211> 10
<212> PRT
<213> Homo Sapiens

<400> 57
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
 1               5                  10  


<210> 58
<211> 14
<212> PRT
<213> Homo Sapiens

<400> 58
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
 1               5                  10                  


<210> 59
<211> 15
<212> PRT
<213> Homo Sapiens

<400> 59
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 60
<211> 32
<212> PRT
<213> Homo Sapiens

<400> 60
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
            20                  25                  30          


<210> 61
<211> 23
<212> PRT
<213> Homo Sapiens

<400> 61
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys
            20              


<210> 62
<211> 15
<212> PRT
<213> Homo Sapiens

<400> 62
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 63
<211> 32
<212> PRT
<213> Homo Sapiens

<400> 63
Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
            20                  25                  30          


<210> 64
<211> 23
<212> PRT
<213> Homo Sapiens

<400> 64
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys
            20              


<210> 65
<211> 15
<212> PRT
<213> Homo Sapiens

<400> 65
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 66
<211> 32
<212> PRT
<213> Homo Sapiens

<400> 66
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys
            20                  25                  30          


<210> 67
<211> 23
<212> PRT
<213> Mus musculus

<400> 67
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys
            20              


<210> 68
<211> 15
<212> PRT
<213> Mus musculus

<400> 68
Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 69
<211> 32
<212> PRT
<213> Mus musculus

<400> 69
Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys
            20                  25                  30          


<210> 70
<211> 11
<212> PRT
<213> Mus musculus

<400> 70
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
 1               5                  10      


<210> 71
<211> 25
<212> PRT
<213> Mus musculus

<400> 71
Asp Val Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr
            20                  25  


<210> 72
<211> 13
<212> PRT
<213> Mus musculus

<400> 72
Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met
 1               5                  10              


<210> 73
<211> 32
<212> PRT
<213> Mus musculus

<400> 73
Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Gln
 1               5                  10                  15      
Leu Ile Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 74
<211> 12
<212> PRT
<213> Mus musculus

<400> 74
Trp Gly Gln Gly Thr Thr Leu Thr Val Ala Ser Ala
 1               5                  10          


<210> 75
<211> 13
<212> PRT
<213> Homo sapiens

<400> 75
Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
 1               5                  10              


<210> 76
<211> 13
<212> PRT
<213> Homo sapiens

<400> 76
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
 1               5                  10              


<210> 77
<211> 13
<212> PRT
<213> Homo sapiens

<400> 77
Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
 1               5                  10              


<210> 78
<211> 32
<212> PRT
<213> Homo sapiens

<400> 78
Arg Ile Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 79
<211> 32
<212> PRT
<213> Homo sapiens

<400> 79
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Phe Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 80
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide

<400> 80
Cys Asp Lys Thr His Thr Gly Gly Gly Ser Gln Arg Leu Met Glu Asp
 1               5                  10                  15      
Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp Phe
            20                  25                  30  


<210> 81
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide
      

<400> 81
Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp
 1               5                  10                  15      
Glu Asp Asp Phe
            20  


<210> 82
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide

<400> 82
Gln Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp
 1               5                  10                  15      
Glu Asp Asp Phe
            20  


<210> 83
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide

<400> 83
Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu
 1               5                  10                  15      
Asp Asp
        


<210> 84
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide

<400> 84
Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp
 1               5                  10      


<210> 85
<211> 218
<212> PRT
<213> Homo sapiens

<400> 85
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
 1               5                  10                  15      
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            20                  25                  30          
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
        35                  40                  45              
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
    50                  55                  60                  
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
65                  70                  75                  80  
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                85                  90                  95      
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
            100                 105                 110         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
        115                 120                 125             
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    130                 135                 140                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
145                 150                 155                 160 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                165                 170                 175     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
            180                 185                 190         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
        195                 200                 205             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215             


<210> 86
<211> 217
<212> PRT
<213> Homo sapiens

<400> 86
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
            100                 105                 110         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
        115                 120                 125             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    130                 135                 140                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145                 150                 155                 160 
Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
                165                 170                 175     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            180                 185                 190         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        195                 200                 205             
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215         


<210> 87
<211> 168
<212> PRT
<213> Homo sapiens

<400> 87
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
 1               5                  10                  15      
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            20                  25                  30          
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp
        35                  40                  45              
Tyr Val Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro
    50                  55                  60                  
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
65                  70                  75                  80  
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                85                  90                  95      
Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr
            100                 105                 110         
Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
        115                 120                 125             
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe
    130                 135                 140                 
Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys
145                 150                 155                 160 
Ser Leu Ser Leu Ser Pro Gly Lys
                165             


<210> 88
<211> 218
<212> PRT
<213> Homo sapiens

<400> 88
Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
 1               5                  10                  15      
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            20                  25                  30          
Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp
        35                  40                  45              
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
    50                  55                  60                  
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
65                  70                  75                  80  
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                85                  90                  95      
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
            100                 105                 110         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu
        115                 120                 125             
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    130                 135                 140                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
145                 150                 155                 160 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                165                 170                 175     
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn
            180                 185                 190         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
        195                 200                 205             
Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
    210                 215             


<210> 89
<211> 107
<212> PRT
<213> Homo sapiens

<400> 89
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
 1               5                  10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105         

