
                                SEQUENCE LISTING

<110> CENTOCOR, INC.

<120> METHOD FOR TREATING PATHOLOGICAL PULMONARY CONDITIONS AND BLEOMYCIN    
	ASSOCIATED PULMONARY FIBROSIS

<130> CEN5168PCT

<140> TO BE ASSIGNED
<141> 2007-10-26

<150> 60/863237     
<151> 2006-10-27  

<160> 5

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 631
<212> PRT
<213> Homo sapiens

<400> 1
Met Asp Tyr Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile
 1               5                  10                  15      
Ser Asp Cys Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His
            20                  25                  30          
Gly His Met Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly
        35                  40                  45              
Thr Gln Gly His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn
    50                  55                  60                  
Gly Thr Pro Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys
65                  70                  75                  80  
Gly Pro Pro Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys
                85                  90                  95      
Gly Leu Arg Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala
            100                 105                 110         
Leu Ser Thr Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His
        115                 120                 125             
Ile Arg Ala Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser
    130                 135                 140                 
Phe Glu Thr Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg
145                 150                 155                 160 
Leu Ser Leu Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys
                165                 170                 175     
His Glu Glu Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro
            180                 185                 190         
Thr Leu Val Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro
        195                 200                 205             
Ala Ala Ser Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro
    210                 215                 220                 
Gly Arg Gln Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu
225                 230                 235                 240 

Leu Arg Leu Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu
                245                 250                 255     
Lys Met Pro Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln
            260                 265                 270         
Ser Cys Glu Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser
        275                 280                 285             
Ile Ser Ser Gln Val Ser Ser Ala Val Met Lys Ser Leu Leu Cys Leu
    290                 295                 300                 
Pro Ser Ser Ile Ser Cys Ala Gln Thr Pro Cys Ile Pro Lys Glu Gly
305                 310                 315                 320 
Ala Ser Pro Thr Ser Ser Ser Asn Glu Asp Ser Ala Ala Asn Gly Ser
                325                 330                 335     
Ala Glu Thr Ser Ala Leu Asp Thr Gly Phe Ser Leu Asn Leu Ser Glu
            340                 345                 350         
Leu Arg Glu Tyr Thr Glu Gly Leu Thr Glu Ala Lys Glu Asp Asp Asp
        355                 360                 365             
Gly Asp His Ser Ser Leu Gln Ser Gly Gln Ser Val Ile Ser Leu Leu
    370                 375                 380                 
Ser Ser Glu Glu Leu Lys Lys Leu Ile Glu Glu Val Lys Val Leu Asp
385                 390                 395                 400 
Glu Ala Thr Leu Lys Gln Leu Asp Gly Ile His Val Thr Ile Leu His
                405                 410                 415     
Lys Glu Glu Gly Ala Gly Leu Gly Phe Ser Leu Ala Gly Gly Ala Asp
            420                 425                 430         
Leu Glu Asn Lys Val Ile Thr Val His Arg Val Phe Pro Asn Gly Leu
        435                 440                 445             
Ala Ser Gln Glu Gly Thr Ile Gln Lys Gly Asn Glu Val Leu Ser Ile
    450                 455                 460                 
Asn Gly Lys Ser Leu Lys Gly Thr Thr His His Asp Ala Leu Ala Ile
465                 470                 475                 480 
Leu Arg Gln Ala Arg Glu Pro Arg Gln Ala Val Ile Val Thr Arg Lys
                485                 490                 495     
Leu Thr Pro Glu Ala Met Pro Asp Leu Asn Ser Ser Thr Asp Ser Ala
            500                 505                 510         
Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr Ala Glu
        515                 520                 525             
Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly Leu Gly
    530                 535                 540                 
Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys Pro Leu
545                 550                 555                 560 
Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser Glu Thr
                565                 570                 575     
Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala Met Gln
            580                 585                 590         
Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu Pro Asp
        595                 600                 605             
Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser Lys Glu
    610                 615                 620                 
Thr Thr Ala Ala Gly Asp Ser
625                 630     


<210> 2
<211> 121
<212> PRT
<213> Homo sapiens

<400> 2
Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr
 1               5                  10                  15      
Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly
            20                  25                  30          
Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys
        35                  40                  45              
Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser
    50                  55                  60                  
Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala
65                  70                  75                  80  
Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu
                85                  90                  95      
Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser
            100                 105                 110         
Lys Glu Thr Thr Ala Ala Gly Asp Ser
        115                 120     


<210> 3
<211> 846
<212> PRT
<213> Homo sapiens

<400> 3
Ser Leu Trp Gly Leu Val Ser Lys Met Pro Pro Glu Lys Val Gln Arg
 1               5                  10                  15      
Leu Tyr Val Asp Phe Pro Gln His Leu Arg His Leu Leu Gly Asp Trp
            20                  25                  30          
Leu Glu Ser Gln Pro Trp Glu Phe Leu Val Gly Ser Asp Ala Phe Cys
        35                  40                  45              
Cys Asn Leu Ala Ser Ala Leu Leu Ser Asp Thr Val Gln His Leu Gln
    50                  55                  60                  
Ala Ser Val Gly Glu Gln Gly Glu Gly Ser Thr Ile Leu Gln His Ile
65                  70                  75                  80  
Ser Thr Leu Glu Ser Ile Tyr Gln Arg Asp Pro Leu Lys Leu Val Ala
                85                  90                  95      
Thr Phe Arg Gln Ile Leu Gln Gly Glu Lys Lys Ala Val Met Glu Gln
            100                 105                 110         
Phe Arg His Leu Pro Met Pro Phe His Trp Lys Gln Glu Glu Leu Lys
        115                 120                 125             
Phe Lys Thr Gly Leu Arg Arg Leu Gln His Arg Val Gly Glu Ile His
    130                 135                 140                 
Leu Leu Arg Glu Ala Leu Gln Lys Gly Ala Glu Ala Gly Gln Val Ser
145                 150                 155                 160 
Leu His Ser Leu Ile Glu Thr Pro Ala Asn Gly Thr Gly Pro Ser Glu
                165                 170                 175     
Ala Leu Ala Met Leu Leu Gln Glu Thr Thr Gly Glu Leu Glu Ala Ala
            180                 185                 190         
Lys Ala Leu Val Leu Lys Arg Ile Gln Ile Trp Lys Arg Gln Gln Gln
        195                 200                 205             
Leu Ala Gly Asn Gly Ala Pro Phe Glu Glu Ser Leu Ala Pro Leu Gln
    210                 215                 220                 
Glu Arg Cys Glu Ser Leu Val Asp Ile Tyr Ser Gln Leu Gln Gln Glu
225                 230                 235                 240 
Val Gly Ala Ala Gly Gly Glu Leu Glu Pro Lys Thr Arg Ala Ser Leu
                245                 250                 255     
Thr Gly Arg Leu Asp Glu Val Leu Arg Thr Leu Val Thr Ser Cys Phe
            260                 265                 270         
Leu Val Glu Lys Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe
        275                 280                 285             
Gln Ala Gly Val Arg Phe Leu Leu Gly Leu Arg Phe Leu Gly Ala Pro
    290                 295                 300                 
Ala Lys Pro Pro Leu Val Arg Ala Asp Met Val Thr Glu Lys Gln Ala
305                 310                 315                 320 
Arg Glu Leu Ser Val Pro Gln Gly Pro Gly Ala Gly Ala Glu Ser Thr
                325                 330                 335     
Gly Glu Ile Ile Asn Asn Thr Val Pro Leu Glu Asn Ser Ile Pro Gly
            340                 345                 350         
Asn Cys Cys Ser Ala Leu Phe Lys Asn Leu Leu Leu Lys Lys Ile Lys
        355                 360                 365             
Arg Cys Glu Arg Lys Gly Thr Glu Ser Val Thr Glu Glu Lys Cys Ala
    370                 375                 380                 
Val Leu Phe Ser Ala Ser Phe Thr Leu Gly Pro Gly Lys Leu Pro Ile
385                 390                 395                 400 
Gln Leu Gln Ala Leu Ser Leu Pro Leu Val Val Ile Val His Gly Asn
                405                 410                 415     
Gln Asp Asn Asn Ala Lys Ala Thr Ile Leu Trp Asp Asn Ala Phe Ser
            420                 425                 430         
Glu Met Asp Arg Val Pro Phe Val Val Ala Glu Arg Val Pro Trp Glu
        435                 440                 445             
Lys Met Cys Glu Thr Leu Asn Leu Lys Phe Met Ala Glu Val Gly Thr
    450                 455                 460                 
Asn Arg Gly Leu Leu Pro Glu His Phe Leu Phe Leu Ala Gln Lys Ile
465                 470                 475                 480 
Phe Asn Asp Asn Ser Leu Ser Met Glu Ala Phe Gln His Arg Ser Val
                485                 490                 495     
Ser Trp Ser Gln Phe Asn Lys Glu Ile Leu Leu Gly Arg Gly Phe Thr
            500                 505                 510         
Phe Trp Gln Trp Phe Asp Gly Val Leu Asp Leu Thr Lys Arg Cys Leu
        515                 520                 525             
Arg Ser Tyr Trp Ser Asp Arg Leu Ile Ile Gly Phe Ile Ser Lys Gln
    530                 535                 540                 
Tyr Val Thr Ser Leu Leu Leu Asn Glu Pro Asp Gly Thr Phe Leu Leu
545                 550                 555                 560 
Arg Phe Ser Asp Ser Glu Ile Gly Gly Ile Thr Ile Ala His Val Ile
                565                 570                 575     
Arg Gly Gln Asp Gly Ser Pro Gln Ile Glu Asn Ile Gln Pro Phe Ser
            580                 585                 590         
Ala Lys Asp Leu Ser Ile Arg Ser Leu Gly Asp Arg Ile Arg Asp Leu
        595                 600                 605             
Ala Gln Leu Lys Asn Leu Tyr Pro Lys Lys Pro Lys Asp Glu Ala Phe
    610                 615                 620                 
Arg Ser His Tyr Lys Pro Glu Gln Met Gly Lys Asp Gly Arg Gly Tyr
625                 630                 635                 640 
Val Pro Ala Thr Ile Lys Met Thr Val Glu Arg Asp Gln Pro Leu Pro
                645                 650                 655     
Thr Pro Glu Leu Gln Met Pro Thr Met Val Pro Ser Tyr Asp Leu Gly
            660                 665                 670         
Met Ala Pro Asp Ser Ser Met Ser Met Gln Leu Gly Pro Asp Met Val
        675                 680                 685             
Pro Gln Val Tyr Pro Pro His Ser His Ser Ile Pro Pro Tyr Gln Gly
    690                 695                 700                 

Leu Ser Pro Glu Glu Ser Val Asn Val Leu Ser Ala Phe Gln Glu Pro
705                 710                 715                 720 
His Leu Gln Met Pro Pro Ser Leu Gly Gln Met Ser Leu Pro Phe Asp
                725                 730                 735     
Gln Pro His Pro Gln Gly Leu Leu Pro Cys Gln Pro Gln Glu His Ala
            740                 745                 750         
Val Ser Ser Pro Asp Pro Leu Leu Cys Ser Asp Val Thr Met Val Glu
        755                 760                 765             
Asp Ser Cys Leu Ser Gln Pro Val Thr Ala Phe Pro Gln Gly Thr Trp
    770                 775                 780                 
Ile Gly Glu Asp Ile Phe Pro Pro Leu Leu Pro Pro Thr Glu Gln Asp
785                 790                 795                 800 
Leu Thr Lys Leu Leu Leu Glu Gly Gln Gly Glu Ser Gly Gly Gly Ser
                805                 810                 815     
Leu Gly Ala Gln Pro Leu Leu Gln Pro Ser His Tyr Gly Gln Ser Gly
            820                 825                 830         
Ile Ser Met Ser His Met Asp Leu Arg Ala Asn Pro Ser Trp
        835                 840                 845     


<210> 4
<211> 624
<212> PRT
<213> Mus musculus

<400> 4
Met Asp Tyr Ser Phe Asp Ile Thr Ala Glu Asp Pro Trp Val Arg Ile
 1               5                  10                  15      
Ser Asp Cys Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His
            20                  25                  30          
Ser His Thr Pro Leu Gln Pro Asn Thr Ser Leu Gly Glu Glu Asp Gly
        35                  40                  45              
Thr Gln Gly Cys Pro Glu Gly Gly Leu Ser Lys Met Asp Ala Ala Asn
    50                  55                  60                  
Gly Ala Pro Arg Val Tyr Lys Ser Ala Asp Gly Ser Thr Val Lys Lys
65                  70                  75                  80  
Gly Pro Pro Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys
                85                  90                  95      
Gly Leu Arg Asn Arg Ala Pro Asp Pro Arg Arg Pro Pro Glu Val Ala
            100                 105                 110         
Ser Ala Ile Gln Pro Thr Pro Val Ser Arg Asp Pro Pro Gly Pro Gln
        115                 120                 125             
Pro Gln Ala Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Asn
    130                 135                 140                 
Phe Gly Ser Ser Gln Leu Pro Asp Arg Gly Val Gln Arg Leu Ser Leu
145                 150                 155                 160 
Gln Pro Ser Ser Gly Glu Thr Thr Lys Phe Pro Gly Lys Gln Asp Gly
                165                 170                 175     
Gly Arg Phe Ser Gly Leu Leu Gly Gln Gly Ala Thr Val Thr Ala Lys
            180                 185                 190         
His Arg Gln Thr Glu Val Glu Ser Met Ser Thr Thr Phe Pro Asn Ser
        195                 200                 205             
Ser Glu Val Arg Asp Pro Gly Leu Pro Glu Ser Pro Pro Pro Ser Gln
    210                 215                 220                 
Arg Pro Ser Thr Lys Ala Leu Ser Pro Asp Pro Leu Leu Arg Leu Leu
225                 230                 235                 240 

Thr Thr Gln Ser Glu Asp Thr Gln Gly Pro Gly Leu Lys Met Pro Ser
                245                 250                 255     
Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Thr Gln Ser Cys Glu Thr
            260                 265                 270         
Lys Leu Leu Asp Glu Lys Ala Ser Lys Leu Tyr Ser Ile Ser Ser Gln
        275                 280                 285             
Leu Ser Ser Ala Val Met Lys Ser Leu Leu Cys Leu Pro Ser Ser Val
    290                 295                 300                 
Ser Cys Gly Gln Ile Thr Cys Ile Pro Lys Glu Arg Val Ser Pro Lys
305                 310                 315                 320 
Ser Pro Cys Asn Asn Ser Ser Ala Ala Glu Gly Phe Gly Glu Ala Met
                325                 330                 335     
Ala Ser Asp Thr Gly Phe Ser Leu Asn Leu Ser Glu Leu Arg Glu Tyr
            340                 345                 350         
Ser Glu Gly Leu Thr Glu Pro Gly Glu Thr Glu Asp Arg Asn His Cys
        355                 360                 365             
Pro Ser Gln Ala Gly Gln Ser Val Ile Ser Leu Leu Ser Ala Glu Glu
    370                 375                 380                 
Leu Glu Lys Leu Ile Glu Glu Val Arg Val Leu Asp Glu Ala Thr Leu
385                 390                 395                 400 
Lys Gln Leu Asp Ser Ile His Val Thr Ile Leu His Lys Glu Glu Gly
                405                 410                 415     
Ala Gly Leu Gly Phe Ser Leu Ala Gly Gly Ala Asp Leu Glu Asn Lys
            420                 425                 430         
Val Ile Thr Val His Arg Val Phe Pro Asn Gly Leu Ala Ser Gln Glu
        435                 440                 445             
Gly Thr Ile Gln Lys Gly Asn Glu Val Leu Ser Ile Asn Gly Lys Ser
    450                 455                 460                 
Leu Lys Gly Ala Thr His Asn Asp Ala Leu Ala Ile Leu Arg Gln Ala
465                 470                 475                 480 
Arg Asp Pro Arg Gln Ala Val Ile Val Thr Arg Arg Thr Thr Val Glu
                485                 490                 495     
Ala Thr His Asp Leu Asn Ser Ser Thr Asp Ser Ala Ala Ser Ala Ser
            500                 505                 510         
Ala Ala Ser Asp Ile Ser Val Glu Ser Lys Glu Ala Thr Ala Cys Thr
        515                 520                 525             
Val Thr Leu Glu Lys Thr Ser Ala Gly Leu Gly Phe Ser Leu Glu Gly
    530                 535                 540                 
Gly Lys Gly Ser Leu His Gly Asp Lys Pro Leu Thr Ile Asn Arg Ile
545                 550                 555                 560 
Phe Lys Gly Thr Glu Gln Gly Glu Met Val Gln Pro Gly Asp Glu Ile
                565                 570                 575     
Leu Gln Leu Ala Gly Thr Ala Val Gln Gly Leu Thr Arg Phe Glu Ala
            580                 585                 590         
Trp Asn Val Ile Lys Ala Leu Pro Asp Gly Pro Val Thr Ile Val Ile
        595                 600                 605             
Arg Arg Thr Ser Leu Gln Cys Lys Gln Thr Thr Ala Ser Ala Asp Ser
    610                 615                 620                 


<210> 5
<211> 118
<212> PRT
<213> Mus musculus

<400> 5

Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Ile Ser Val Glu Ser Lys
 1               5                  10                  15      
Glu Ala Thr Ala Cys Thr Val Thr Leu Glu Lys Thr Ser Ala Gly Leu
            20                  25                  30          
Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys Pro
        35                  40                  45              
Leu Thr Ile Asn Arg Ile Phe Lys Gly Thr Glu Gln Gly Glu Met Val
    50                  55                  60                  
Gln Pro Gly Asp Glu Ile Leu Gln Leu Ala Gly Thr Ala Val Gln Gly
65                  70                  75                  80  
Leu Thr Arg Phe Glu Ala Trp Asn Val Ile Lys Ala Leu Pro Asp Gly
                85                  90                  95      
Pro Val Thr Ile Val Ile Arg Arg Thr Ser Leu Gln Cys Lys Gln Thr
            100                 105                 110         
Thr Ala Ser Ala Asp Ser
        115             

