                         SEQUENCE LISTING

<110>  Cook, Mark
       Petkovich, Martin
       Helvig, Christian
       Hellestad, Erica
       Crawford, Keith
 
<120>  METHODS OF REDUCING PHOSPHATE ABSORPTION

<130>  960296.00428

<160>  21    

<170>  PatentIn version 3.3

<210>  1
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Val Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Glu Ala Leu Asp Ala Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Lys Val Ala Lys Asn Leu Ile Leu Phe Leu Gly Asp Gly Leu Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Lys Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Arg Phe Pro Tyr Leu 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Phe Gln Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Gln Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Met Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Ala Asp Ala 
225                 230                 235                 240 


Ser Gln Asn Gly Ile Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ala Lys His Gln Gly Ala Trp Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Met Gln Ala Ser Leu Asp Gln Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Gly Asp Thr Lys Tyr Glu Ile Leu Arg Asp Pro Thr Leu Asp 
    290                 295                 300                 


Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Val Ala Tyr Gln Ala Val Thr Glu Ala Val Met 
            340                 345                 350         


Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp 
        355                 360                 365             


Thr Leu Thr Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Gln Asp Ser Lys Ala Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Phe Asn Ser Gly Val Arg Pro Asp Val Asn Glu Ser Glu 
            420                 425                 430         


Ser Gly Ser Pro Asp Tyr Gln Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Gln Ser Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala 
                485                 490                 495     


Leu Pro Ala Cys Thr Thr Asp Ala Ala His Pro Val Ala Ala Ser Leu 
            500                 505                 510         


Pro Leu Leu Ala Gly Thr Leu Leu Leu Leu Gly Ala Ser Ala Ala Pro 
        515                 520                 525             


<210>  2
<211>  559
<212>  PRT
<213>  mouse

<400>  2

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Ser Val Ile Pro Val Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Lys Lys Ala Ala Glu Ala Leu Asp Ala Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Thr Ser Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Leu Glu Gly 
65                  70                  75                  80  


His Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Arg Phe Pro Tyr Met 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Ser Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Ser Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Thr Asn Tyr Lys Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asp Gln Cys Asn Thr Thr Phe 
    130                 135                 140                 


Gly Asn Glu Val Phe Ser Val Met Tyr Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ser 
                165                 170                 175     


Gly Thr Tyr Val His Thr Val Asn Arg Asn Trp Tyr Gly Asp Ala Asp 
            180                 185                 190         


Met Pro Ala Ser Ala Leu Arg Glu Gly Cys Lys Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asn Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Ala Gly Thr Pro Asp Pro Glu Tyr Pro Asn Asp Ala 
225                 230                 235                 240 


Asn Glu Thr Gly Thr Arg Leu Asp Gly Arg Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ser Lys His Gln Gly Ser Gln Tyr Val Trp Asn Arg Glu Gln Leu 
            260                 265                 270         


Ile Gln Lys Ala Gln Asp Pro Ser Val Thr Tyr Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Val Asp Thr Lys Phe Asp Ile Gln Arg Asp Pro Leu Met Asp 
    290                 295                 300                 


Pro Ser Leu Lys Asp Met Thr Glu Thr Ala Val Lys Val Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Lys Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp Arg 
                325                 330                 335     


Gly His His Leu Gly Thr Ala Tyr Leu Ala Leu Thr Glu Ala Val Met 
            340                 345                 350         


Phe Asp Leu Ala Ile Glu Arg Ala Ser Gln Leu Thr Ser Glu Arg Asp 
        355                 360                 365             


Thr Leu Thr Ile Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Leu Asn 
385                 390                 395                 400 


Ala Leu Asp Gly Lys Pro Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Gly Thr Gly Glu Arg Pro Asn Val Thr Ala Ala Glu Ser 
            420                 425                 430         


Ser Gly Ser Ser Tyr Arg Arg Gln Ala Ala Val Pro Val Lys Ser Glu 
        435                 440                 445             


Thr His Gly Gly Glu Asp Val Ala Ile Phe Ala Arg Gly Pro Gln Ala 
    450                 455                 460                 


His Leu Val His Gly Val Gln Glu Gln Asn Tyr Ile Ala His Val Met 
465                 470                 475                 480 


Ala Ser Ala Gly Cys Leu Glu Pro Tyr Thr Asp Cys Gly Leu Ala Pro 
                485                 490                 495     


Pro Ala Asp Glu Ser Gln Thr Thr Thr Thr Thr Arg Gln Thr Thr Ile 
            500                 505                 510         


Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Pro Val His Asn 
        515                 520                 525             


Ser Ala Arg Ser Leu Gly Pro Ala Thr Ala Pro Leu Ala Leu Ala Leu 
    530                 535                 540                 


Leu Ala Gly Met Leu Met Leu Leu Leu Gly Ala Pro Ala Glu Ser 
545                 550                 555                 


<210>  3
<211>  540
<212>  PRT
<213>  rat

<400>  3

Met Gln Gly Asp Trp Val Leu Leu Leu Leu Leu Gly Leu Arg Ile His 
1               5                   10                  15      


Leu Ser Phe Gly Val Ile Pro Val Glu Glu Glu Asn Pro Val Phe Trp 
            20                  25                  30          


Asn Gln Lys Ala Lys Glu Ala Leu Asp Val Ala Lys Lys Leu Gln Pro 
        35                  40                  45              


Ile Gln Thr Ser Ala Lys Asn Leu Ile Leu Phe Leu Gly Asp Gly Met 
    50                  55                  60                  


Gly Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Leu Gly 
65                  70                  75                  80  


Gly His Leu Gly Pro Glu Thr Pro Leu Ala Met Asp His Phe Pro Phe 
                85                  90                  95      


Thr Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser 
            100                 105                 110         


Ala Gly Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Tyr Lys 
        115                 120                 125             


Thr Ile Gly Val Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Ser Thr 
    130                 135                 140                 


Phe Gly Asn Glu Val Phe Ser Val Met His Arg Ala Lys Lys Ala Gly 
145                 150                 155                 160 


Lys Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro 
                165                 170                 175     


Ala Gly Thr Tyr Ala His Thr Val Asn Arg Asp Trp Tyr Ser Asp Ala 
            180                 185                 190         


Asp Met Pro Ser Ser Ala Leu Gln Glu Gly Cys Lys Asp Ile Ala Thr 
        195                 200                 205             


Gln Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg 
    210                 215                 220                 


Lys Ser Met Phe Pro Lys Gly Thr Pro Asp Pro Glu Tyr Pro Gly Asp 
225                 230                 235                 240 


Ser Asp Gln Ser Gly Val Arg Leu Asp Ser Arg Asn Leu Val Glu Glu 
                245                 250                 255     


Trp Leu Ala Lys Tyr Gln Gly Thr Arg Tyr Val Trp Asn Arg Glu Gln 
            260                 265                 270         


Leu Met Arg Ala Ser Gln Asp Pro Ala Val Thr Arg Leu Met Gly Leu 
        275                 280                 285             


Phe Glu Pro Thr Glu Met Lys Tyr Asp Val Asn Arg Asn Ala Ser Ala 
    290                 295                 300                 


Asp Pro Ser Leu Ala Glu Met Thr Glu Val Ala Val Arg Leu Leu Ser 
305                 310                 315                 320 


Arg Asn Pro Gln Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp 
                325                 330                 335     


Gln Gly His His Ala Gly Thr Ala Tyr Leu Ala Leu Thr Glu Ala Ala 
            340                 345                 350         


Met Phe Asp Ser Ala Ile Glu Lys Ala Ser Gln Leu Thr Asn Glu Lys 
        355                 360                 365             


Asp Thr Leu Thr Leu Ile Thr Ala Asp His Ser His Val Phe Ala Phe 
    370                 375                 380                 


Gly Gly Tyr Thr Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Leu 
385                 390                 395                 400 


Asn Ala Gln Asp Gly Lys Ser Tyr Thr Ser Ile Leu Tyr Gly Asn Gly 
                405                 410                 415     


Pro Gly Tyr Val Leu Asn Ser Gly Asn Arg Pro Asn Val Thr Asp Ala 
            420                 425                 430         


Glu Ser Gly Asp Val Asn Tyr Lys Gln Gln Ala Ala Val Pro Leu Ser 
        435                 440                 445             


Ser Glu Thr His Gly Gly Glu Asp Val Ala Ile Phe Ala Arg Gly Pro 
    450                 455                 460                 


Gln Ala His Leu Val His Gly Val Gln Glu Gln Asn Tyr Ile Ala His 
465                 470                 475                 480 


Val Met Ala Phe Ala Gly Cys Leu Glu Pro Tyr Thr Asp Cys Gly Leu 
                485                 490                 495     


Ala Pro Pro Ala Asp Glu Asn Arg Pro Thr Thr Pro Val Gln Asn Ser 
            500                 505                 510         


Ala Ile Thr Met Asn Asn Val Leu Leu Ser Leu Gln Leu Leu Val Ser 
        515                 520                 525             


Met Leu Leu Leu Val Gly Thr Ala Leu Val Val Ser 
    530                 535                 540 


<210>  4
<211>  562
<212>  PRT
<213>  rat

<400>  4

Met Gln Gly Ala Trp Val Leu Leu Leu Leu Gly Phe Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Ser Val Ile Pro Val Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Gln Lys Ala Ala Asp Ala Leu Asn Val Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Thr Ser Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Leu Glu Gly 
65                  70                  75                  80  


Asn Leu Gly Pro Glu Thr Pro Leu Ala Met Asp His Phe Pro Tyr Met 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Ser Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Ser Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Thr Asn Tyr Lys Thr 
        115                 120                 125             


Ile Gly Val Ser Ala Ala Ala Arg Phe Asp Gln Cys Asn Thr Thr Phe 
    130                 135                 140                 


Gly Asn Glu Val Leu Ser Val Met Tyr Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Thr Tyr Val His Thr Val Asn Arg Asn Trp Tyr Gly Asp Ala Asp 
            180                 185                 190         


Met Pro Ala Ser Ala Leu Gln Glu Gly Cys Lys Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asn Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Ala Gly Thr Pro Asp Pro Glu Tyr Pro Asn Asp Val 
225                 230                 235                 240 


Asn Glu Thr Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ser Lys His Gln Gly Ser Gln Tyr Val Trp Asn Arg Gln Glu Leu 
            260                 265                 270         


Ile Gln Lys Ser Leu Asp Pro Ser Val Thr Tyr Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Val Asp Thr Lys Phe Glu Ile Gln Arg Asp Pro Leu Met Asp 
    290                 295                 300                 


Pro Ser Leu Lys Asp Met Thr Glu Ala Ala Leu His Val Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Lys Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp Arg 
                325                 330                 335     


Gly His His Leu Gly Thr Ala Tyr Leu Ala Leu Thr Glu Ala Val Met 
            340                 345                 350         


Leu Asp Ser Ala Ile Glu Arg Ala Ser Gln Leu Thr Ser Glu Gln Asp 
        355                 360                 365             


Thr Leu Thr Ile Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Thr Ser Ile Phe Gly Leu Ala Pro Leu Asn 
385                 390                 395                 400 


Ala Leu Asp Gly Lys Pro Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Gly Thr Gly Glu Arg Pro Asn Val Thr Asp Ala Glu Ser 
            420                 425                 430         


His Asp Pro Ser Tyr Gln Gln Gln Ala Ala Val Pro Val Lys Ser Glu 
        435                 440                 445             


Thr His Gly Gly Glu Asp Val Ala Ile Phe Ala Arg Gly Pro Gln Ala 
    450                 455                 460                 


His Leu Leu His Gly Val Gln Glu Gln Asn Tyr Ile Ala His Val Met 
465                 470                 475                 480 


Ala Phe Ala Gly Cys Leu Glu Pro Tyr Thr Asp Cys Gly Leu Ala Pro 
                485                 490                 495     


Pro Ala Asp Glu Asn Arg Pro Thr Thr Pro Val Gln Asn Ser Thr Thr 
            500                 505                 510         


Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Arg 
        515                 520                 525             


Val Gln Asn Ser Ala Ser Ser Leu Gly Pro Ala Thr Gly Pro Leu Ala 
    530                 535                 540                 


Leu Ala Leu Leu Ala Lys Ala Leu Met Leu Leu Leu Gly Ala Pro Ala 
545                 550                 555                 560 


Asp Phe 
        


<210>  5
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  5

Gly Pro Glu Thr Pro Leu Ala Met 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  6

Lys Thr Tyr Asn Val Asp Arg Gln 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  7

Lys Ala Asn Phe Gln Thr Ile Gly 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  8

Lys Gln Ala Gly Lys Ser Val Gly 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  9

His Thr Val Asn Arg Asn Trp Tyr 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  10

Met Phe Pro Met Gly Thr Pro Asp 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  11

Glu Ala Ala Leu Arg Leu Leu Ser 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  12

Gly Arg Ile Asp His Gly His His 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  13

Phe Gly Gly Tyr Thr Leu Arg Gly 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  14

Leu Ser Ser Glu Thr His Gly Gly 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  15

Gln Ala Ala Glu Ala Leu Asp Ala 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  16

Arg Ile Leu Lys Gly Gln Lys Asn 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  17

Gln His Ala Ser Pro Ala Gly Thr 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  18

Asp Ala Asp Met Pro Ala Ser Ala 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  19

His Gln Gly Ala Trp Tyr Val Trp 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  20

Glu Leu Met Gln Ala Ser Leu Asp 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  21

Leu Thr Ser Glu Glu Asp Thr Leu 
1               5               


