                         SEQUENCE LISTING

<110>  Evonik Degussa GmbH
 
<120>  Allele des prpD1-Gens aus coryneformen Bakterien

<130>  2006E00233

<160>  20    

<170>  PatentIn version 3.3

<210>  1
<211>  1497
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(1494)
<223>  prpD1-Wildtyp-Gen

<220>
<221>  misc_feature
<222>  (815)..(815)
<223>  Cytosin

<400>  1
atg cgc atc cac gat gtt tat acc cac ctt tcg gcc gat aac ttt ccc       48
Met Arg Ile His Asp Val Tyr Thr His Leu Ser Ala Asp Asn Phe Pro         
1               5                   10                  15              

aaa gca gag cac ctt gcg tgg aaa ttc tcc gag ctt gcc acc gac ccc       96
Lys Ala Glu His Leu Ala Trp Lys Phe Ser Glu Leu Ala Thr Asp Pro         
            20                  25                  30                  

gtg gag gtg aca ccg gat gtt tcg gag atg atc atc aac cgg atc atc      144
Val Glu Val Thr Pro Asp Val Ser Glu Met Ile Ile Asn Arg Ile Ile         
        35                  40                  45                      

gac aac gcg gcg gtg tct gcc gcg tcg gtg ttg cgc cgg cct gtg act      192
Asp Asn Ala Ala Val Ser Ala Ala Ser Val Leu Arg Arg Pro Val Thr         
    50                  55                  60                          

gtg gcc agg caa caa gcg cag tcc cat ccg cgg gaa aag ggc gga aaa      240
Val Ala Arg Gln Gln Ala Gln Ser His Pro Arg Glu Lys Gly Gly Lys         
65                  70                  75                  80          

gtt ttt gga att tca ggc agc tac tca cca gag tgg gct gcc ttt gct      288
Val Phe Gly Ile Ser Gly Ser Tyr Ser Pro Glu Trp Ala Ala Phe Ala         
                85                  90                  95              

aat ggt gtg gcc gta cgt gaa ttg gac ttc cac gat aca ttt tta gca      336
Asn Gly Val Ala Val Arg Glu Leu Asp Phe His Asp Thr Phe Leu Ala         
            100                 105                 110                 

gct gaa tac tcc cat ccc ggc gac aat att cca cca ctt ctt gca gta      384
Ala Glu Tyr Ser His Pro Gly Asp Asn Ile Pro Pro Leu Leu Ala Val         
        115                 120                 125                     

gcg cag gct cag aga agc agc ggc agg gat ctc att cgg ggt atc gcc      432
Ala Gln Ala Gln Arg Ser Ser Gly Arg Asp Leu Ile Arg Gly Ile Ala         
    130                 135                 140                         

act gcc tat gag gtg cag gtg gaa ttg gtg agg ggg atc tgc ttg cat      480
Thr Ala Tyr Glu Val Gln Val Glu Leu Val Arg Gly Ile Cys Leu His         
145                 150                 155                 160         

gag cac aaa att gat cac gta gcc cac ctt ggt ccc agc gct gca gcg      528
Glu His Lys Ile Asp His Val Ala His Leu Gly Pro Ser Ala Ala Ala         
                165                 170                 175             

ggt ttg ggc acg ttg ttg cat gta gat gag gaa acc atc tac cag gcg      576
Gly Leu Gly Thr Leu Leu His Val Asp Glu Glu Thr Ile Tyr Gln Ala         
            180                 185                 190                 

atc ggc cag gca ttg cac acc acg acg gct acg agg cag tcg cga aaa      624
Ile Gly Gln Ala Leu His Thr Thr Thr Ala Thr Arg Gln Ser Arg Lys         
        195                 200                 205                     

ggt gag att tcc agc tgg aag gcg ttc gcg cca gcg ttt gcg gga aag      672
Gly Glu Ile Ser Ser Trp Lys Ala Phe Ala Pro Ala Phe Ala Gly Lys         
    210                 215                 220                         

atg gcc att gag gcg atg gat cgt gcg atg cgt ggg gag ggt tcg ccc      720
Met Ala Ile Glu Ala Met Asp Arg Ala Met Arg Gly Glu Gly Ser Pro         
225                 230                 235                 240         

gca ccg att tgg gag ggc gaa gac ggg gtc atc gcg tgg ctg tta tcg      768
Ala Pro Ile Trp Glu Gly Glu Asp Gly Val Ile Ala Trp Leu Leu Ser         
                245                 250                 255             

ggc aaa gat cat gtt tat cat gtg cca ttg ccg gaa cac ggc gag ccc      816
Gly Lys Asp His Val Tyr His Val Pro Leu Pro Glu His Gly Glu Pro         
            260                 265                 270                 

aag ctg ggg att cta gag act tac aca aag gaa cat tca gcg gaa tat      864
Lys Leu Gly Ile Leu Glu Thr Tyr Thr Lys Glu His Ser Ala Glu Tyr         
        275                 280                 285                     

caa tcg cag gca ccg att gat ctg gcg cgc agg atg aag cca ctg gtt      912
Gln Ser Gln Ala Pro Ile Asp Leu Ala Arg Arg Met Lys Pro Leu Val         
    290                 295                 300                         

gac gcg gct ggc gga acg gaa cac att gca gag att gtg ctg cgc acc      960
Asp Ala Ala Gly Gly Thr Glu His Ile Ala Glu Ile Val Leu Arg Thr         
305                 310                 315                 320         

agt cac cac acg cat tat gtg att ggc act ggg gcg aac gat ccg cag     1008
Ser His His Thr His Tyr Val Ile Gly Thr Gly Ala Asn Asp Pro Gln         
                325                 330                 335             

aag atg gat ccg cag gcc tcg cgt gaa acc ctg gat cat tcc atc atg     1056
Lys Met Asp Pro Gln Ala Ser Arg Glu Thr Leu Asp His Ser Ile Met         
            340                 345                 350                 

tac att ttc gcc gtc gcg ctt caa gat ggc gtg tgg cac cac gag ttt     1104
Tyr Ile Phe Ala Val Ala Leu Gln Asp Gly Val Trp His His Glu Phe         
        355                 360                 365                     

tcc tac acc cgc aag cgt tcc acc cgc ccg gaa act gtg gag ctg tgg     1152
Ser Tyr Thr Arg Lys Arg Ser Thr Arg Pro Glu Thr Val Glu Leu Trp         
    370                 375                 380                         

cac aag att cgc acc gtg gag gat cct gaa tgg acg cgc cga tac cat     1200
His Lys Ile Arg Thr Val Glu Asp Pro Glu Trp Thr Arg Arg Tyr His         
385                 390                 395                 400         

tct gat gat cct gca aaa aag gcc ttt ggt gcg aaa gca gtg atc aca     1248
Ser Asp Asp Pro Ala Lys Lys Ala Phe Gly Ala Lys Ala Val Ile Thr         
                405                 410                 415             

atg gct gat ggc acc gtg att gag gat gaa ttg gct gtc gcg gat gcc     1296
Met Ala Asp Gly Thr Val Ile Glu Asp Glu Leu Ala Val Ala Asp Ala         
            420                 425                 430                 

cac ccg ctg ggt gct cgg ccg ttt gcg cgg gag aat tac att gaa aaa     1344
His Pro Leu Gly Ala Arg Pro Phe Ala Arg Glu Asn Tyr Ile Glu Lys         
        435                 440                 445                     

ttc cgc aca ctc gcg cag ggg att gtc att gat tca gaa cag gaa cgc     1392
Phe Arg Thr Leu Ala Gln Gly Ile Val Ile Asp Ser Glu Gln Glu Arg         
    450                 455                 460                         

ttc ttg cat gcc gtg caa agc ctg cct gac ctg gat gat ctt gat cag     1440
Phe Leu His Ala Val Gln Ser Leu Pro Asp Leu Asp Asp Leu Asp Gln         
465                 470                 475                 480         

ctc aac atc gaa gtc gac ata agc aac cag gcc gcg acg aaa gcg ggg     1488
Leu Asn Ile Glu Val Asp Ile Ser Asn Gln Ala Ala Thr Lys Ala Gly         
                485                 490                 495             

ctg tta tga                                                         1497
Leu Leu                                                                 
                                                                        


<210>  2
<211>  498
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  2

Met Arg Ile His Asp Val Tyr Thr His Leu Ser Ala Asp Asn Phe Pro 
1               5                   10                  15      


Lys Ala Glu His Leu Ala Trp Lys Phe Ser Glu Leu Ala Thr Asp Pro 
            20                  25                  30          


Val Glu Val Thr Pro Asp Val Ser Glu Met Ile Ile Asn Arg Ile Ile 
        35                  40                  45              


Asp Asn Ala Ala Val Ser Ala Ala Ser Val Leu Arg Arg Pro Val Thr 
    50                  55                  60                  


Val Ala Arg Gln Gln Ala Gln Ser His Pro Arg Glu Lys Gly Gly Lys 
65                  70                  75                  80  


Val Phe Gly Ile Ser Gly Ser Tyr Ser Pro Glu Trp Ala Ala Phe Ala 
                85                  90                  95      


Asn Gly Val Ala Val Arg Glu Leu Asp Phe His Asp Thr Phe Leu Ala 
            100                 105                 110         


Ala Glu Tyr Ser His Pro Gly Asp Asn Ile Pro Pro Leu Leu Ala Val 
        115                 120                 125             


Ala Gln Ala Gln Arg Ser Ser Gly Arg Asp Leu Ile Arg Gly Ile Ala 
    130                 135                 140                 


Thr Ala Tyr Glu Val Gln Val Glu Leu Val Arg Gly Ile Cys Leu His 
145                 150                 155                 160 


Glu His Lys Ile Asp His Val Ala His Leu Gly Pro Ser Ala Ala Ala 
                165                 170                 175     


Gly Leu Gly Thr Leu Leu His Val Asp Glu Glu Thr Ile Tyr Gln Ala 
            180                 185                 190         


Ile Gly Gln Ala Leu His Thr Thr Thr Ala Thr Arg Gln Ser Arg Lys 
        195                 200                 205             


Gly Glu Ile Ser Ser Trp Lys Ala Phe Ala Pro Ala Phe Ala Gly Lys 
    210                 215                 220                 


Met Ala Ile Glu Ala Met Asp Arg Ala Met Arg Gly Glu Gly Ser Pro 
225                 230                 235                 240 


Ala Pro Ile Trp Glu Gly Glu Asp Gly Val Ile Ala Trp Leu Leu Ser 
                245                 250                 255     


Gly Lys Asp His Val Tyr His Val Pro Leu Pro Glu His Gly Glu Pro 
            260                 265                 270         


Lys Leu Gly Ile Leu Glu Thr Tyr Thr Lys Glu His Ser Ala Glu Tyr 
        275                 280                 285             


Gln Ser Gln Ala Pro Ile Asp Leu Ala Arg Arg Met Lys Pro Leu Val 
    290                 295                 300                 


Asp Ala Ala Gly Gly Thr Glu His Ile Ala Glu Ile Val Leu Arg Thr 
305                 310                 315                 320 


Ser His His Thr His Tyr Val Ile Gly Thr Gly Ala Asn Asp Pro Gln 
                325                 330                 335     


Lys Met Asp Pro Gln Ala Ser Arg Glu Thr Leu Asp His Ser Ile Met 
            340                 345                 350         


Tyr Ile Phe Ala Val Ala Leu Gln Asp Gly Val Trp His His Glu Phe 
        355                 360                 365             


Ser Tyr Thr Arg Lys Arg Ser Thr Arg Pro Glu Thr Val Glu Leu Trp 
    370                 375                 380                 


His Lys Ile Arg Thr Val Glu Asp Pro Glu Trp Thr Arg Arg Tyr His 
385                 390                 395                 400 


Ser Asp Asp Pro Ala Lys Lys Ala Phe Gly Ala Lys Ala Val Ile Thr 
                405                 410                 415     


Met Ala Asp Gly Thr Val Ile Glu Asp Glu Leu Ala Val Ala Asp Ala 
            420                 425                 430         


His Pro Leu Gly Ala Arg Pro Phe Ala Arg Glu Asn Tyr Ile Glu Lys 
        435                 440                 445             


Phe Arg Thr Leu Ala Gln Gly Ile Val Ile Asp Ser Glu Gln Glu Arg 
    450                 455                 460                 


Phe Leu His Ala Val Gln Ser Leu Pro Asp Leu Asp Asp Leu Asp Gln 
465                 470                 475                 480 


Leu Asn Ile Glu Val Asp Ile Ser Asn Gln Ala Ala Thr Lys Ala Gly 
                485                 490                 495     


Leu Leu 
        


<210>  3
<211>  3000
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  misc_feature
<222>  (1)..(750)
<223>  stromaufwrts der CDS gelegene Sequenz

<220>
<221>  CDS
<222>  (751)..(2244)
<223>  prpD1-Wildtyp-Gen

<220>
<221>  misc_feature
<222>  (1565)..(1565)
<223>  Cytosin

<220>
<221>  misc_feature
<222>  (2245)..(3000)
<223>  stromabwrts der CDS gelegene Sequenz

<400>  3
ggttccacct tcgccataac gcttgacgac gcctccctcc ttcactctcg gcgcatcatt     60

ttggcccacg gcgccgttga cgatctgcca gaggtagaag gactgtcaga tttttgggga    120

accaaagtgt tgcactgcgc ttactgccac ggctttgagg cccgcgattc tgaaatcgtc    180

gtggtgggta cctcgcccat ggctgcgcac caagcgttga tgttctcgca gttgtccaaa    240

actgtcagct tggtgggcac gatcgacatt gatgaacaaa ccagcgagag cctagatagt    300

gctggagtaa aagtgttggg caccaatgcg gtgcgcgtat ccgccgaagg tgatggcctg    360

tctgtggaac tgtccgaagg cgatcattta agctgcgaca acatcgtggt ggcatctcgt    420

ccactggtgg atggcacgct gtacacccaa cttggtggtc agatggaaga aaacccgatg    480

ggcaggttca ttccaggtac ccaaaccggg cgcactccta ttgaaggtgt gtgggctgcc    540

ggaaacgcgc aagctcccat ggcgatggtc tatggttccg ctgctcaagg cgtgatggct    600

ggagcagaga tcaactttga tctgatcctg gaagatattt ccgtggcaag cgcgcagagc    660

taaactgcgt gaggttgtgg cctgtcacac ataatcggcc tagggtggga ctttaaggaa    720

acagtgcaca aataaatctc aaggagcccc atg cgc atc cac gat gtt tat acc     774
                                 Met Arg Ile His Asp Val Tyr Thr        
                                 1               5                      

cac ctt tcg gcc gat aac ttt ccc aaa gca gag cac ctt gcg tgg aaa      822
His Leu Ser Ala Asp Asn Phe Pro Lys Ala Glu His Leu Ala Trp Lys         
    10                  15                  20                          

ttc tcc gag ctt gcc acc gac ccc gtg gag gtg aca ccg gat gtt tcg      870
Phe Ser Glu Leu Ala Thr Asp Pro Val Glu Val Thr Pro Asp Val Ser         
25                  30                  35                  40          

gag atg atc atc aac cgg atc atc gac aac gcg gcg gtg tct gcc gcg      918
Glu Met Ile Ile Asn Arg Ile Ile Asp Asn Ala Ala Val Ser Ala Ala         
                45                  50                  55              

tcg gtg ttg cgc cgg cct gtg act gtg gcc agg caa caa gcg cag tcc      966
Ser Val Leu Arg Arg Pro Val Thr Val Ala Arg Gln Gln Ala Gln Ser         
            60                  65                  70                  

cat ccg cgg gaa aag ggc gga aaa gtt ttt gga att tca ggc agc tac     1014
His Pro Arg Glu Lys Gly Gly Lys Val Phe Gly Ile Ser Gly Ser Tyr         
        75                  80                  85                      

tca cca gag tgg gct gcc ttt gct aat ggt gtg gcc gta cgt gaa ttg     1062
Ser Pro Glu Trp Ala Ala Phe Ala Asn Gly Val Ala Val Arg Glu Leu         
    90                  95                  100                         

gac ttc cac gat aca ttt tta gca gct gaa tac tcc cat ccc ggc gac     1110
Asp Phe His Asp Thr Phe Leu Ala Ala Glu Tyr Ser His Pro Gly Asp         
105                 110                 115                 120         

aat att cca cca ctt ctt gca gta gcg cag gct cag aga agc agc ggc     1158
Asn Ile Pro Pro Leu Leu Ala Val Ala Gln Ala Gln Arg Ser Ser Gly         
                125                 130                 135             

agg gat ctc att cgg ggt atc gcc act gcc tat gag gtg cag gtg gaa     1206
Arg Asp Leu Ile Arg Gly Ile Ala Thr Ala Tyr Glu Val Gln Val Glu         
            140                 145                 150                 

ttg gtg agg ggg atc tgc ttg cat gag cac aaa att gat cac gta gcc     1254
Leu Val Arg Gly Ile Cys Leu His Glu His Lys Ile Asp His Val Ala         
        155                 160                 165                     

cac ctt ggt ccc agc gct gca gcg ggt ttg ggc acg ttg ttg cat gta     1302
His Leu Gly Pro Ser Ala Ala Ala Gly Leu Gly Thr Leu Leu His Val         
    170                 175                 180                         

gat gag gaa acc atc tac cag gcg atc ggc cag gca ttg cac acc acg     1350
Asp Glu Glu Thr Ile Tyr Gln Ala Ile Gly Gln Ala Leu His Thr Thr         
185                 190                 195                 200         

acg gct acg agg cag tcg cga aaa ggt gag att tcc agc tgg aag gcg     1398
Thr Ala Thr Arg Gln Ser Arg Lys Gly Glu Ile Ser Ser Trp Lys Ala         
                205                 210                 215             

ttc gcg cca gcg ttt gcg gga aag atg gcc att gag gcg atg gat cgt     1446
Phe Ala Pro Ala Phe Ala Gly Lys Met Ala Ile Glu Ala Met Asp Arg         
            220                 225                 230                 

gcg atg cgt ggg gag ggt tcg ccc gca ccg att tgg gag ggc gaa gac     1494
Ala Met Arg Gly Glu Gly Ser Pro Ala Pro Ile Trp Glu Gly Glu Asp         
        235                 240                 245                     

ggg gtc atc gcg tgg ctg tta tcg ggc aaa gat cat gtt tat cat gtg     1542
Gly Val Ile Ala Trp Leu Leu Ser Gly Lys Asp His Val Tyr His Val         
    250                 255                 260                         

cca ttg ccg gaa cac ggc gag ccc aag ctg ggg att cta gag act tac     1590
Pro Leu Pro Glu His Gly Glu Pro Lys Leu Gly Ile Leu Glu Thr Tyr         
265                 270                 275                 280         

aca aag gaa cat tca gcg gaa tat caa tcg cag gca ccg att gat ctg     1638
Thr Lys Glu His Ser Ala Glu Tyr Gln Ser Gln Ala Pro Ile Asp Leu         
                285                 290                 295             

gcg cgc agg atg aag cca ctg gtt gac gcg gct ggc gga acg gaa cac     1686
Ala Arg Arg Met Lys Pro Leu Val Asp Ala Ala Gly Gly Thr Glu His         
            300                 305                 310                 

att gca gag att gtg ctg cgc acc agt cac cac acg cat tat gtg att     1734
Ile Ala Glu Ile Val Leu Arg Thr Ser His His Thr His Tyr Val Ile         
        315                 320                 325                     

ggc act ggg gcg aac gat ccg cag aag atg gat ccg cag gcc tcg cgt     1782
Gly Thr Gly Ala Asn Asp Pro Gln Lys Met Asp Pro Gln Ala Ser Arg         
    330                 335                 340                         

gaa acc ctg gat cat tcc atc atg tac att ttc gcc gtc gcg ctt caa     1830
Glu Thr Leu Asp His Ser Ile Met Tyr Ile Phe Ala Val Ala Leu Gln         
345                 350                 355                 360         

gat ggc gtg tgg cac cac gag ttt tcc tac acc cgc aag cgt tcc acc     1878
Asp Gly Val Trp His His Glu Phe Ser Tyr Thr Arg Lys Arg Ser Thr         
                365                 370                 375             

cgc ccg gaa act gtg gag ctg tgg cac aag att cgc acc gtg gag gat     1926
Arg Pro Glu Thr Val Glu Leu Trp His Lys Ile Arg Thr Val Glu Asp         
            380                 385                 390                 

cct gaa tgg acg cgc cga tac cat tct gat gat cct gca aaa aag gcc     1974
Pro Glu Trp Thr Arg Arg Tyr His Ser Asp Asp Pro Ala Lys Lys Ala         
        395                 400                 405                     

ttt ggt gcg aaa gca gtg atc aca atg gct gat ggc acc gtg att gag     2022
Phe Gly Ala Lys Ala Val Ile Thr Met Ala Asp Gly Thr Val Ile Glu         
    410                 415                 420                         

gat gaa ttg gct gtc gcg gat gcc cac ccg ctg ggt gct cgg ccg ttt     2070
Asp Glu Leu Ala Val Ala Asp Ala His Pro Leu Gly Ala Arg Pro Phe         
425                 430                 435                 440         

gcg cgg gag aat tac att gaa aaa ttc cgc aca ctc gcg cag ggg att     2118
Ala Arg Glu Asn Tyr Ile Glu Lys Phe Arg Thr Leu Ala Gln Gly Ile         
                445                 450                 455             

gtc att gat tca gaa cag gaa cgc ttc ttg cat gcc gtg caa agc ctg     2166
Val Ile Asp Ser Glu Gln Glu Arg Phe Leu His Ala Val Gln Ser Leu         
            460                 465                 470                 

cct gac ctg gat gat ctt gat cag ctc aac atc gaa gtc gac ata agc     2214
Pro Asp Leu Asp Asp Leu Asp Gln Leu Asn Ile Glu Val Asp Ile Ser         
        475                 480                 485                     

aac cag gcc gcg acg aaa gcg ggg ctg tta tgaatctctt ttcgaatggt       2264
Asn Gln Ala Ala Thr Lys Ala Gly Leu Leu                                 
    490                 495                                             

gttgatgtgg ggaggcgtcg acaagcattt aaagcggcac tcgccgcacc ccacatcgcc   2324

cggctgcccg gcgcattctc ccctctgatt gcgcgctcca tcgaagaagc cggcttcgaa   2384

ggcgtctacg tttccggcgc cgtcatagct gctgacctgg cactacccga tatcggcttg   2444

acgacgctga ccgaagtcgc ccaccgcgcg cggcaaattg cgcgcgtcac agacctagga   2504

gtgcttgtcg acgccgacac cggctttggc gaacccatgt cggccgcacg caccgtcgcc   2564

gaattggagg acgccggtgt ggccggatgc caccttgaag accaagtcaa ccccaaacgt   2624

tgcgggcact tggacggcaa agaagtcgtg cgcacagacg tgatggttcg acgcatcgca   2684

gccgccgtct cggcccggcg cgacccgaac tttgtcatct gcgcccgcac cgacgccgct   2744

ggagtggaag gaatcgacgc cgccattgag cgcgcgaaag cctacttaga tgcgggcgcc   2804

gacatgattt tcaccgaagc cctccacagc gaagccgact tccgatactt ccggcacgcc   2864

atccctgatg ccttgttgct ggcgaatatg accgaatttg gcaaaacgac gctgctgtca   2924

gccgacgtgt tggaagagat tggctacaac gccgtgatct accccgtgac cacgctgcgt   2984

attgccatgg gacaag                                                   3000


<210>  4
<211>  498
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  4

Met Arg Ile His Asp Val Tyr Thr His Leu Ser Ala Asp Asn Phe Pro 
1               5                   10                  15      


Lys Ala Glu His Leu Ala Trp Lys Phe Ser Glu Leu Ala Thr Asp Pro 
            20                  25                  30          


Val Glu Val Thr Pro Asp Val Ser Glu Met Ile Ile Asn Arg Ile Ile 
        35                  40                  45              


Asp Asn Ala Ala Val Ser Ala Ala Ser Val Leu Arg Arg Pro Val Thr 
    50                  55                  60                  


Val Ala Arg Gln Gln Ala Gln Ser His Pro Arg Glu Lys Gly Gly Lys 
65                  70                  75                  80  


Val Phe Gly Ile Ser Gly Ser Tyr Ser Pro Glu Trp Ala Ala Phe Ala 
                85                  90                  95      


Asn Gly Val Ala Val Arg Glu Leu Asp Phe His Asp Thr Phe Leu Ala 
            100                 105                 110         


Ala Glu Tyr Ser His Pro Gly Asp Asn Ile Pro Pro Leu Leu Ala Val 
        115                 120                 125             


Ala Gln Ala Gln Arg Ser Ser Gly Arg Asp Leu Ile Arg Gly Ile Ala 
    130                 135                 140                 


Thr Ala Tyr Glu Val Gln Val Glu Leu Val Arg Gly Ile Cys Leu His 
145                 150                 155                 160 


Glu His Lys Ile Asp His Val Ala His Leu Gly Pro Ser Ala Ala Ala 
                165                 170                 175     


Gly Leu Gly Thr Leu Leu His Val Asp Glu Glu Thr Ile Tyr Gln Ala 
            180                 185                 190         


Ile Gly Gln Ala Leu His Thr Thr Thr Ala Thr Arg Gln Ser Arg Lys 
        195                 200                 205             


Gly Glu Ile Ser Ser Trp Lys Ala Phe Ala Pro Ala Phe Ala Gly Lys 
    210                 215                 220                 


Met Ala Ile Glu Ala Met Asp Arg Ala Met Arg Gly Glu Gly Ser Pro 
225                 230                 235                 240 


Ala Pro Ile Trp Glu Gly Glu Asp Gly Val Ile Ala Trp Leu Leu Ser 
                245                 250                 255     


Gly Lys Asp His Val Tyr His Val Pro Leu Pro Glu His Gly Glu Pro 
            260                 265                 270         


Lys Leu Gly Ile Leu Glu Thr Tyr Thr Lys Glu His Ser Ala Glu Tyr 
        275                 280                 285             


Gln Ser Gln Ala Pro Ile Asp Leu Ala Arg Arg Met Lys Pro Leu Val 
    290                 295                 300                 


Asp Ala Ala Gly Gly Thr Glu His Ile Ala Glu Ile Val Leu Arg Thr 
305                 310                 315                 320 


Ser His His Thr His Tyr Val Ile Gly Thr Gly Ala Asn Asp Pro Gln 
                325                 330                 335     


Lys Met Asp Pro Gln Ala Ser Arg Glu Thr Leu Asp His Ser Ile Met 
            340                 345                 350         


Tyr Ile Phe Ala Val Ala Leu Gln Asp Gly Val Trp His His Glu Phe 
        355                 360                 365             


Ser Tyr Thr Arg Lys Arg Ser Thr Arg Pro Glu Thr Val Glu Leu Trp 
    370                 375                 380                 


His Lys Ile Arg Thr Val Glu Asp Pro Glu Trp Thr Arg Arg Tyr His 
385                 390                 395                 400 


Ser Asp Asp Pro Ala Lys Lys Ala Phe Gly Ala Lys Ala Val Ile Thr 
                405                 410                 415     


Met Ala Asp Gly Thr Val Ile Glu Asp Glu Leu Ala Val Ala Asp Ala 
            420                 425                 430         


His Pro Leu Gly Ala Arg Pro Phe Ala Arg Glu Asn Tyr Ile Glu Lys 
        435                 440                 445             


Phe Arg Thr Leu Ala Gln Gly Ile Val Ile Asp Ser Glu Gln Glu Arg 
    450                 455                 460                 


Phe Leu His Ala Val Gln Ser Leu Pro Asp Leu Asp Asp Leu Asp Gln 
465                 470                 475                 480 


Leu Asn Ile Glu Val Asp Ile Ser Asn Gln Ala Ala Thr Lys Ala Gly 
                485                 490                 495     


Leu Leu 
        


<210>  5
<211>  1497
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(1494)
<223>  prpD1-Allel

<220>
<221>  mutation
<222>  (815)..(815)
<223>  C -> T Transition

<400>  5
atg cgc atc cac gat gtt tat acc cac ctt tcg gcc gat aac ttt ccc       48
Met Arg Ile His Asp Val Tyr Thr His Leu Ser Ala Asp Asn Phe Pro         
1               5                   10                  15              

aaa gca gag cac ctt gcg tgg aaa ttc tcc gag ctt gcc acc gac ccc       96
Lys Ala Glu His Leu Ala Trp Lys Phe Ser Glu Leu Ala Thr Asp Pro         
            20                  25                  30                  

gtg gag gtg aca ccg gat gtt tcg gag atg atc atc aac cgg atc atc      144
Val Glu Val Thr Pro Asp Val Ser Glu Met Ile Ile Asn Arg Ile Ile         
        35                  40                  45                      

gac aac gcg gcg gtg tct gcc gcg tcg gtg ttg cgc cgg cct gtg act      192
Asp Asn Ala Ala Val Ser Ala Ala Ser Val Leu Arg Arg Pro Val Thr         
    50                  55                  60                          

gtg gcc agg caa caa gcg cag tcc cat ccg cgg gaa aag ggc gga aaa      240
Val Ala Arg Gln Gln Ala Gln Ser His Pro Arg Glu Lys Gly Gly Lys         
65                  70                  75                  80          

gtt ttt gga att tca ggc agc tac tca cca gag tgg gct gcc ttt gct      288
Val Phe Gly Ile Ser Gly Ser Tyr Ser Pro Glu Trp Ala Ala Phe Ala         
                85                  90                  95              

aat ggt gtg gcc gta cgt gaa ttg gac ttc cac gat aca ttt tta gca      336
Asn Gly Val Ala Val Arg Glu Leu Asp Phe His Asp Thr Phe Leu Ala         
            100                 105                 110                 

gct gaa tac tcc cat ccc ggc gac aat att cca cca ctt ctt gca gta      384
Ala Glu Tyr Ser His Pro Gly Asp Asn Ile Pro Pro Leu Leu Ala Val         
        115                 120                 125                     

gcg cag gct cag aga agc agc ggc agg gat ctc att cgg ggt atc gcc      432
Ala Gln Ala Gln Arg Ser Ser Gly Arg Asp Leu Ile Arg Gly Ile Ala         
    130                 135                 140                         

act gcc tat gag gtg cag gtg gaa ttg gtg agg ggg atc tgc ttg cat      480
Thr Ala Tyr Glu Val Gln Val Glu Leu Val Arg Gly Ile Cys Leu His         
145                 150                 155                 160         

gag cac aaa att gat cac gta gcc cac ctt ggt ccc agc gct gca gcg      528
Glu His Lys Ile Asp His Val Ala His Leu Gly Pro Ser Ala Ala Ala         
                165                 170                 175             

ggt ttg ggc acg ttg ttg cat gta gat gag gaa acc atc tac cag gcg      576
Gly Leu Gly Thr Leu Leu His Val Asp Glu Glu Thr Ile Tyr Gln Ala         
            180                 185                 190                 

atc ggc cag gca ttg cac acc acg acg gct acg agg cag tcg cga aaa      624
Ile Gly Gln Ala Leu His Thr Thr Thr Ala Thr Arg Gln Ser Arg Lys         
        195                 200                 205                     

ggt gag att tcc agc tgg aag gcg ttc gcg cca gcg ttt gcg gga aag      672
Gly Glu Ile Ser Ser Trp Lys Ala Phe Ala Pro Ala Phe Ala Gly Lys         
    210                 215                 220                         

atg gcc att gag gcg atg gat cgt gcg atg cgt ggg gag ggt tcg ccc      720
Met Ala Ile Glu Ala Met Asp Arg Ala Met Arg Gly Glu Gly Ser Pro         
225                 230                 235                 240         

gca ccg att tgg gag ggc gaa gac ggg gtc atc gcg tgg ctg tta tcg      768
Ala Pro Ile Trp Glu Gly Glu Asp Gly Val Ile Ala Trp Leu Leu Ser         
                245                 250                 255             

ggc aaa gat cat gtt tat cat gtg cca ttg ccg gaa cac ggc gag ctc      816
Gly Lys Asp His Val Tyr His Val Pro Leu Pro Glu His Gly Glu Leu         
            260                 265                 270                 

aag ctg ggg att cta gag act tac aca aag gaa cat tca gcg gaa tat      864
Lys Leu Gly Ile Leu Glu Thr Tyr Thr Lys Glu His Ser Ala Glu Tyr         
        275                 280                 285                     

caa tcg cag gca ccg att gat ctg gcg cgc agg atg aag cca ctg gtt      912
Gln Ser Gln Ala Pro Ile Asp Leu Ala Arg Arg Met Lys Pro Leu Val         
    290                 295                 300                         

gac gcg gct ggc gga acg gaa cac att gca gag att gtg ctg cgc acc      960
Asp Ala Ala Gly Gly Thr Glu His Ile Ala Glu Ile Val Leu Arg Thr         
305                 310                 315                 320         

agt cac cac acg cat tat gtg att ggc act ggg gcg aac gat ccg cag     1008
Ser His His Thr His Tyr Val Ile Gly Thr Gly Ala Asn Asp Pro Gln         
                325                 330                 335             

aag atg gat ccg cag gcc tcg cgt gaa acc ctg gat cat tcc atc atg     1056
Lys Met Asp Pro Gln Ala Ser Arg Glu Thr Leu Asp His Ser Ile Met         
            340                 345                 350                 

tac att ttc gcc gtc gcg ctt caa gat ggc gtg tgg cac cac gag ttt     1104
Tyr Ile Phe Ala Val Ala Leu Gln Asp Gly Val Trp His His Glu Phe         
        355                 360                 365                     

tcc tac acc cgc aag cgt tcc acc cgc ccg gaa act gtg gag ctg tgg     1152
Ser Tyr Thr Arg Lys Arg Ser Thr Arg Pro Glu Thr Val Glu Leu Trp         
    370                 375                 380                         

cac aag att cgc acc gtg gag gat cct gaa tgg acg cgc cga tac cat     1200
His Lys Ile Arg Thr Val Glu Asp Pro Glu Trp Thr Arg Arg Tyr His         
385                 390                 395                 400         

tct gat gat cct gca aaa aag gcc ttt ggt gcg aaa gca gtg atc aca     1248
Ser Asp Asp Pro Ala Lys Lys Ala Phe Gly Ala Lys Ala Val Ile Thr         
                405                 410                 415             

atg gct gat ggc acc gtg att gag gat gaa ttg gct gtc gcg gat gcc     1296
Met Ala Asp Gly Thr Val Ile Glu Asp Glu Leu Ala Val Ala Asp Ala         
            420                 425                 430                 

cac ccg ctg ggt gct cgg ccg ttt gcg cgg gag aat tac att gaa aaa     1344
His Pro Leu Gly Ala Arg Pro Phe Ala Arg Glu Asn Tyr Ile Glu Lys         
        435                 440                 445                     

ttc cgc aca ctc gcg cag ggg att gtc att gat tca gaa cag gaa cgc     1392
Phe Arg Thr Leu Ala Gln Gly Ile Val Ile Asp Ser Glu Gln Glu Arg         
    450                 455                 460                         

ttc ttg cat gcc gtg caa agc ctg cct gac ctg gat gat ctt gat cag     1440
Phe Leu His Ala Val Gln Ser Leu Pro Asp Leu Asp Asp Leu Asp Gln         
465                 470                 475                 480         

ctc aac atc gaa gtc gac ata agc aac cag gcc gcg acg aaa gcg ggg     1488
Leu Asn Ile Glu Val Asp Ile Ser Asn Gln Ala Ala Thr Lys Ala Gly         
                485                 490                 495             

ctg tta tga                                                         1497
Leu Leu                                                                 
                                                                        


<210>  6
<211>  498
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  6

Met Arg Ile His Asp Val Tyr Thr His Leu Ser Ala Asp Asn Phe Pro 
1               5                   10                  15      


Lys Ala Glu His Leu Ala Trp Lys Phe Ser Glu Leu Ala Thr Asp Pro 
            20                  25                  30          


Val Glu Val Thr Pro Asp Val Ser Glu Met Ile Ile Asn Arg Ile Ile 
        35                  40                  45              


Asp Asn Ala Ala Val Ser Ala Ala Ser Val Leu Arg Arg Pro Val Thr 
    50                  55                  60                  


Val Ala Arg Gln Gln Ala Gln Ser His Pro Arg Glu Lys Gly Gly Lys 
65                  70                  75                  80  


Val Phe Gly Ile Ser Gly Ser Tyr Ser Pro Glu Trp Ala Ala Phe Ala 
                85                  90                  95      


Asn Gly Val Ala Val Arg Glu Leu Asp Phe His Asp Thr Phe Leu Ala 
            100                 105                 110         


Ala Glu Tyr Ser His Pro Gly Asp Asn Ile Pro Pro Leu Leu Ala Val 
        115                 120                 125             


Ala Gln Ala Gln Arg Ser Ser Gly Arg Asp Leu Ile Arg Gly Ile Ala 
    130                 135                 140                 


Thr Ala Tyr Glu Val Gln Val Glu Leu Val Arg Gly Ile Cys Leu His 
145                 150                 155                 160 


Glu His Lys Ile Asp His Val Ala His Leu Gly Pro Ser Ala Ala Ala 
                165                 170                 175     


Gly Leu Gly Thr Leu Leu His Val Asp Glu Glu Thr Ile Tyr Gln Ala 
            180                 185                 190         


Ile Gly Gln Ala Leu His Thr Thr Thr Ala Thr Arg Gln Ser Arg Lys 
        195                 200                 205             


Gly Glu Ile Ser Ser Trp Lys Ala Phe Ala Pro Ala Phe Ala Gly Lys 
    210                 215                 220                 


Met Ala Ile Glu Ala Met Asp Arg Ala Met Arg Gly Glu Gly Ser Pro 
225                 230                 235                 240 


Ala Pro Ile Trp Glu Gly Glu Asp Gly Val Ile Ala Trp Leu Leu Ser 
                245                 250                 255     


Gly Lys Asp His Val Tyr His Val Pro Leu Pro Glu His Gly Glu Leu 
            260                 265                 270         


Lys Leu Gly Ile Leu Glu Thr Tyr Thr Lys Glu His Ser Ala Glu Tyr 
        275                 280                 285             


Gln Ser Gln Ala Pro Ile Asp Leu Ala Arg Arg Met Lys Pro Leu Val 
    290                 295                 300                 


Asp Ala Ala Gly Gly Thr Glu His Ile Ala Glu Ile Val Leu Arg Thr 
305                 310                 315                 320 


Ser His His Thr His Tyr Val Ile Gly Thr Gly Ala Asn Asp Pro Gln 
                325                 330                 335     


Lys Met Asp Pro Gln Ala Ser Arg Glu Thr Leu Asp His Ser Ile Met 
            340                 345                 350         


Tyr Ile Phe Ala Val Ala Leu Gln Asp Gly Val Trp His His Glu Phe 
        355                 360                 365             


Ser Tyr Thr Arg Lys Arg Ser Thr Arg Pro Glu Thr Val Glu Leu Trp 
    370                 375                 380                 


His Lys Ile Arg Thr Val Glu Asp Pro Glu Trp Thr Arg Arg Tyr His 
385                 390                 395                 400 


Ser Asp Asp Pro Ala Lys Lys Ala Phe Gly Ala Lys Ala Val Ile Thr 
                405                 410                 415     


Met Ala Asp Gly Thr Val Ile Glu Asp Glu Leu Ala Val Ala Asp Ala 
            420                 425                 430         


His Pro Leu Gly Ala Arg Pro Phe Ala Arg Glu Asn Tyr Ile Glu Lys 
        435                 440                 445             


Phe Arg Thr Leu Ala Gln Gly Ile Val Ile Asp Ser Glu Gln Glu Arg 
    450                 455                 460                 


Phe Leu His Ala Val Gln Ser Leu Pro Asp Leu Asp Asp Leu Asp Gln 
465                 470                 475                 480 


Leu Asn Ile Glu Val Asp Ile Ser Asn Gln Ala Ala Thr Lys Ala Gly 
                485                 490                 495     


Leu Leu 
        


<210>  7
<211>  3000
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  misc_feature
<222>  (1)..(750)
<223>  stromaufwrts der CDS gelegene Sequenz

<220>
<221>  primer_bind
<222>  (661)..(680)
<223>  Bindungsstelle Primer prpD1_XL_A1

<220>
<221>  CDS
<222>  (751)..(2244)
<223>  prpD1-Allel

<220>
<221>  mutation
<222>  (1565)..(1565)
<223>  C -> T Transition

<220>
<221>  misc_feature
<222>  (2245)..(3000)
<223>  stromabwrts der CDS gelegene Sequenz

<220>
<221>  primer_bind
<222>  (2258)..(2277)
<223>  Bindungsstelle Primer prpD1_XL_E1

<400>  7
ggttccacct tcgccataac gcttgacgac gcctccctcc ttcactctcg gcgcatcatt     60

ttggcccacg gcgccgttga cgatctgcca gaggtagaag gactgtcaga tttttgggga    120

accaaagtgt tgcactgcgc ttactgccac ggctttgagg cccgcgattc tgaaatcgtc    180

gtggtgggta cctcgcccat ggctgcgcac caagcgttga tgttctcgca gttgtccaaa    240

actgtcagct tggtgggcac gatcgacatt gatgaacaaa ccagcgagag cctagatagt    300

gctggagtaa aagtgttggg caccaatgcg gtgcgcgtat ccgccgaagg tgatggcctg    360

tctgtggaac tgtccgaagg cgatcattta agctgcgaca acatcgtggt ggcatctcgt    420

ccactggtgg atggcacgct gtacacccaa cttggtggtc agatggaaga aaacccgatg    480

ggcaggttca ttccaggtac ccaaaccggg cgcactccta ttgaaggtgt gtgggctgcc    540

ggaaacgcgc aagctcccat ggcgatggtc tatggttccg ctgctcaagg cgtgatggct    600

ggagcagaga tcaactttga tctgatcctg gaagatattt ccgtggcaag cgcgcagagc    660

taaactgcgt gaggttgtgg cctgtcacac ataatcggcc tagggtggga ctttaaggaa    720

acagtgcaca aataaatctc aaggagcccc atg cgc atc cac gat gtt tat acc     774
                                 Met Arg Ile His Asp Val Tyr Thr        
                                 1               5                      

cac ctt tcg gcc gat aac ttt ccc aaa gca gag cac ctt gcg tgg aaa      822
His Leu Ser Ala Asp Asn Phe Pro Lys Ala Glu His Leu Ala Trp Lys         
    10                  15                  20                          

ttc tcc gag ctt gcc acc gac ccc gtg gag gtg aca ccg gat gtt tcg      870
Phe Ser Glu Leu Ala Thr Asp Pro Val Glu Val Thr Pro Asp Val Ser         
25                  30                  35                  40          

gag atg atc atc aac cgg atc atc gac aac gcg gcg gtg tct gcc gcg      918
Glu Met Ile Ile Asn Arg Ile Ile Asp Asn Ala Ala Val Ser Ala Ala         
                45                  50                  55              

tcg gtg ttg cgc cgg cct gtg act gtg gcc agg caa caa gcg cag tcc      966
Ser Val Leu Arg Arg Pro Val Thr Val Ala Arg Gln Gln Ala Gln Ser         
            60                  65                  70                  

cat ccg cgg gaa aag ggc gga aaa gtt ttt gga att tca ggc agc tac     1014
His Pro Arg Glu Lys Gly Gly Lys Val Phe Gly Ile Ser Gly Ser Tyr         
        75                  80                  85                      

tca cca gag tgg gct gcc ttt gct aat ggt gtg gcc gta cgt gaa ttg     1062
Ser Pro Glu Trp Ala Ala Phe Ala Asn Gly Val Ala Val Arg Glu Leu         
    90                  95                  100                         

gac ttc cac gat aca ttt tta gca gct gaa tac tcc cat ccc ggc gac     1110
Asp Phe His Asp Thr Phe Leu Ala Ala Glu Tyr Ser His Pro Gly Asp         
105                 110                 115                 120         

aat att cca cca ctt ctt gca gta gcg cag gct cag aga agc agc ggc     1158
Asn Ile Pro Pro Leu Leu Ala Val Ala Gln Ala Gln Arg Ser Ser Gly         
                125                 130                 135             

agg gat ctc att cgg ggt atc gcc act gcc tat gag gtg cag gtg gaa     1206
Arg Asp Leu Ile Arg Gly Ile Ala Thr Ala Tyr Glu Val Gln Val Glu         
            140                 145                 150                 

ttg gtg agg ggg atc tgc ttg cat gag cac aaa att gat cac gta gcc     1254
Leu Val Arg Gly Ile Cys Leu His Glu His Lys Ile Asp His Val Ala         
        155                 160                 165                     

cac ctt ggt ccc agc gct gca gcg ggt ttg ggc acg ttg ttg cat gta     1302
His Leu Gly Pro Ser Ala Ala Ala Gly Leu Gly Thr Leu Leu His Val         
    170                 175                 180                         

gat gag gaa acc atc tac cag gcg atc ggc cag gca ttg cac acc acg     1350
Asp Glu Glu Thr Ile Tyr Gln Ala Ile Gly Gln Ala Leu His Thr Thr         
185                 190                 195                 200         

acg gct acg agg cag tcg cga aaa ggt gag att tcc agc tgg aag gcg     1398
Thr Ala Thr Arg Gln Ser Arg Lys Gly Glu Ile Ser Ser Trp Lys Ala         
                205                 210                 215             

ttc gcg cca gcg ttt gcg gga aag atg gcc att gag gcg atg gat cgt     1446
Phe Ala Pro Ala Phe Ala Gly Lys Met Ala Ile Glu Ala Met Asp Arg         
            220                 225                 230                 

gcg atg cgt ggg gag ggt tcg ccc gca ccg att tgg gag ggc gaa gac     1494
Ala Met Arg Gly Glu Gly Ser Pro Ala Pro Ile Trp Glu Gly Glu Asp         
        235                 240                 245                     

ggg gtc atc gcg tgg ctg tta tcg ggc aaa gat cat gtt tat cat gtg     1542
Gly Val Ile Ala Trp Leu Leu Ser Gly Lys Asp His Val Tyr His Val         
    250                 255                 260                         

cca ttg ccg gaa cac ggc gag ctc aag ctg ggg att cta gag act tac     1590
Pro Leu Pro Glu His Gly Glu Leu Lys Leu Gly Ile Leu Glu Thr Tyr         
265                 270                 275                 280         

aca aag gaa cat tca gcg gaa tat caa tcg cag gca ccg att gat ctg     1638
Thr Lys Glu His Ser Ala Glu Tyr Gln Ser Gln Ala Pro Ile Asp Leu         
                285                 290                 295             

gcg cgc agg atg aag cca ctg gtt gac gcg gct ggc gga acg gaa cac     1686
Ala Arg Arg Met Lys Pro Leu Val Asp Ala Ala Gly Gly Thr Glu His         
            300                 305                 310                 

att gca gag att gtg ctg cgc acc agt cac cac acg cat tat gtg att     1734
Ile Ala Glu Ile Val Leu Arg Thr Ser His His Thr His Tyr Val Ile         
        315                 320                 325                     

ggc act ggg gcg aac gat ccg cag aag atg gat ccg cag gcc tcg cgt     1782
Gly Thr Gly Ala Asn Asp Pro Gln Lys Met Asp Pro Gln Ala Ser Arg         
    330                 335                 340                         

gaa acc ctg gat cat tcc atc atg tac att ttc gcc gtc gcg ctt caa     1830
Glu Thr Leu Asp His Ser Ile Met Tyr Ile Phe Ala Val Ala Leu Gln         
345                 350                 355                 360         

gat ggc gtg tgg cac cac gag ttt tcc tac acc cgc aag cgt tcc acc     1878
Asp Gly Val Trp His His Glu Phe Ser Tyr Thr Arg Lys Arg Ser Thr         
                365                 370                 375             

cgc ccg gaa act gtg gag ctg tgg cac aag att cgc acc gtg gag gat     1926
Arg Pro Glu Thr Val Glu Leu Trp His Lys Ile Arg Thr Val Glu Asp         
            380                 385                 390                 

cct gaa tgg acg cgc cga tac cat tct gat gat cct gca aaa aag gcc     1974
Pro Glu Trp Thr Arg Arg Tyr His Ser Asp Asp Pro Ala Lys Lys Ala         
        395                 400                 405                     

ttt ggt gcg aaa gca gtg atc aca atg gct gat ggc acc gtg att gag     2022
Phe Gly Ala Lys Ala Val Ile Thr Met Ala Asp Gly Thr Val Ile Glu         
    410                 415                 420                         

gat gaa ttg gct gtc gcg gat gcc cac ccg ctg ggt gct cgg ccg ttt     2070
Asp Glu Leu Ala Val Ala Asp Ala His Pro Leu Gly Ala Arg Pro Phe         
425                 430                 435                 440         

gcg cgg gag aat tac att gaa aaa ttc cgc aca ctc gcg cag ggg att     2118
Ala Arg Glu Asn Tyr Ile Glu Lys Phe Arg Thr Leu Ala Gln Gly Ile         
                445                 450                 455             

gtc att gat tca gaa cag gaa cgc ttc ttg cat gcc gtg caa agc ctg     2166
Val Ile Asp Ser Glu Gln Glu Arg Phe Leu His Ala Val Gln Ser Leu         
            460                 465                 470                 

cct gac ctg gat gat ctt gat cag ctc aac atc gaa gtc gac ata agc     2214
Pro Asp Leu Asp Asp Leu Asp Gln Leu Asn Ile Glu Val Asp Ile Ser         
        475                 480                 485                     

aac cag gcc gcg acg aaa gcg ggg ctg tta tgaatctctt ttcgaatggt       2264
Asn Gln Ala Ala Thr Lys Ala Gly Leu Leu                                 
    490                 495                                             

gttgatgtgg ggaggcgtcg acaagcattt aaagcggcac tcgccgcacc ccacatcgcc   2324

cggctgcccg gcgcattctc ccctctgatt gcgcgctcca tcgaagaagc cggcttcgaa   2384

ggcgtctacg tttccggcgc cgtcatagct gctgacctgg cactacccga tatcggcttg   2444

acgacgctga ccgaagtcgc ccaccgcgcg cggcaaattg cgcgcgtcac agacctagga   2504

gtgcttgtcg acgccgacac cggctttggc gaacccatgt cggccgcacg caccgtcgcc   2564

gaattggagg acgccggtgt ggccggatgc caccttgaag accaagtcaa ccccaaacgt   2624

tgcgggcact tggacggcaa agaagtcgtg cgcacagacg tgatggttcg acgcatcgca   2684

gccgccgtct cggcccggcg cgacccgaac tttgtcatct gcgcccgcac cgacgccgct   2744

ggagtggaag gaatcgacgc cgccattgag cgcgcgaaag cctacttaga tgcgggcgcc   2804

gacatgattt tcaccgaagc cctccacagc gaagccgact tccgatactt ccggcacgcc   2864

atccctgatg ccttgttgct ggcgaatatg accgaatttg gcaaaacgac gctgctgtca   2924

gccgacgtgt tggaagagat tggctacaac gccgtgatct accccgtgac cacgctgcgt   2984

attgccatgg gacaag                                                   3000


<210>  8
<211>  498
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  8

Met Arg Ile His Asp Val Tyr Thr His Leu Ser Ala Asp Asn Phe Pro 
1               5                   10                  15      


Lys Ala Glu His Leu Ala Trp Lys Phe Ser Glu Leu Ala Thr Asp Pro 
            20                  25                  30          


Val Glu Val Thr Pro Asp Val Ser Glu Met Ile Ile Asn Arg Ile Ile 
        35                  40                  45              


Asp Asn Ala Ala Val Ser Ala Ala Ser Val Leu Arg Arg Pro Val Thr 
    50                  55                  60                  


Val Ala Arg Gln Gln Ala Gln Ser His Pro Arg Glu Lys Gly Gly Lys 
65                  70                  75                  80  


Val Phe Gly Ile Ser Gly Ser Tyr Ser Pro Glu Trp Ala Ala Phe Ala 
                85                  90                  95      


Asn Gly Val Ala Val Arg Glu Leu Asp Phe His Asp Thr Phe Leu Ala 
            100                 105                 110         


Ala Glu Tyr Ser His Pro Gly Asp Asn Ile Pro Pro Leu Leu Ala Val 
        115                 120                 125             


Ala Gln Ala Gln Arg Ser Ser Gly Arg Asp Leu Ile Arg Gly Ile Ala 
    130                 135                 140                 


Thr Ala Tyr Glu Val Gln Val Glu Leu Val Arg Gly Ile Cys Leu His 
145                 150                 155                 160 


Glu His Lys Ile Asp His Val Ala His Leu Gly Pro Ser Ala Ala Ala 
                165                 170                 175     


Gly Leu Gly Thr Leu Leu His Val Asp Glu Glu Thr Ile Tyr Gln Ala 
            180                 185                 190         


Ile Gly Gln Ala Leu His Thr Thr Thr Ala Thr Arg Gln Ser Arg Lys 
        195                 200                 205             


Gly Glu Ile Ser Ser Trp Lys Ala Phe Ala Pro Ala Phe Ala Gly Lys 
    210                 215                 220                 


Met Ala Ile Glu Ala Met Asp Arg Ala Met Arg Gly Glu Gly Ser Pro 
225                 230                 235                 240 


Ala Pro Ile Trp Glu Gly Glu Asp Gly Val Ile Ala Trp Leu Leu Ser 
                245                 250                 255     


Gly Lys Asp His Val Tyr His Val Pro Leu Pro Glu His Gly Glu Leu 
            260                 265                 270         


Lys Leu Gly Ile Leu Glu Thr Tyr Thr Lys Glu His Ser Ala Glu Tyr 
        275                 280                 285             


Gln Ser Gln Ala Pro Ile Asp Leu Ala Arg Arg Met Lys Pro Leu Val 
    290                 295                 300                 


Asp Ala Ala Gly Gly Thr Glu His Ile Ala Glu Ile Val Leu Arg Thr 
305                 310                 315                 320 


Ser His His Thr His Tyr Val Ile Gly Thr Gly Ala Asn Asp Pro Gln 
                325                 330                 335     


Lys Met Asp Pro Gln Ala Ser Arg Glu Thr Leu Asp His Ser Ile Met 
            340                 345                 350         


Tyr Ile Phe Ala Val Ala Leu Gln Asp Gly Val Trp His His Glu Phe 
        355                 360                 365             


Ser Tyr Thr Arg Lys Arg Ser Thr Arg Pro Glu Thr Val Glu Leu Trp 
    370                 375                 380                 


His Lys Ile Arg Thr Val Glu Asp Pro Glu Trp Thr Arg Arg Tyr His 
385                 390                 395                 400 


Ser Asp Asp Pro Ala Lys Lys Ala Phe Gly Ala Lys Ala Val Ile Thr 
                405                 410                 415     


Met Ala Asp Gly Thr Val Ile Glu Asp Glu Leu Ala Val Ala Asp Ala 
            420                 425                 430         


His Pro Leu Gly Ala Arg Pro Phe Ala Arg Glu Asn Tyr Ile Glu Lys 
        435                 440                 445             


Phe Arg Thr Leu Ala Gln Gly Ile Val Ile Asp Ser Glu Gln Glu Arg 
    450                 455                 460                 


Phe Leu His Ala Val Gln Ser Leu Pro Asp Leu Asp Asp Leu Asp Gln 
465                 470                 475                 480 


Leu Asn Ile Glu Val Asp Ile Ser Asn Gln Ala Ala Thr Lys Ala Gly 
                485                 490                 495     


Leu Leu 
        


<210>  9
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer prpD1_XL_A1


<220>
<221>  misc_feature
<222>  (1)..(2)

<220>
<221>  misc_structure
<222>  (3)..(8)
<223>  EcoRI-Restriktionsschnittstelle

<400>  9
gcgaattcta aactgcgtga ggttgtgg                                        28


<210>  10
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer prpD1_XL_E1


<220>
<221>  misc_feature
<222>  (1)..(2)

<220>
<221>  misc_structure
<222>  (3)..(8)
<223>  EcoRI-Restriktionsschnittstelle

<400>  10
gcgaattctc cccacatcaa caccattc                                        28


<210>  11
<211>  1263
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(1263)
<223>  lysC-Wildtyp-Gen

<400>  11
gtg gcc ctg gtc gta cag aaa tat ggc ggt tcc tcg ctt gag agt gcg       48
Met Ala Leu Val Val Gln Lys Tyr Gly Gly Ser Ser Leu Glu Ser Ala         
1               5                   10                  15              

gaa cgc att aga aac gtc gct gaa cgg atc gtt gcc acc aag aag gct       96
Glu Arg Ile Arg Asn Val Ala Glu Arg Ile Val Ala Thr Lys Lys Ala         
            20                  25                  30                  

gga aat gat gtc gtg gtt gtc tgc tcc gca atg gga gac acc acg gat      144
Gly Asn Asp Val Val Val Val Cys Ser Ala Met Gly Asp Thr Thr Asp         
        35                  40                  45                      

gaa ctt cta gaa ctt gca gcg gca gtg aat ccc gtt ccg cca gct cgt      192
Glu Leu Leu Glu Leu Ala Ala Ala Val Asn Pro Val Pro Pro Ala Arg         
    50                  55                  60                          

gaa atg gat atg ctc ctg act gct ggt gag cgt att tct aac gct ctc      240
Glu Met Asp Met Leu Leu Thr Ala Gly Glu Arg Ile Ser Asn Ala Leu         
65                  70                  75                  80          

gtc gcc atg gct att gag tcc ctt ggc gca gaa gcc caa tct ttc acg      288
Val Ala Met Ala Ile Glu Ser Leu Gly Ala Glu Ala Gln Ser Phe Thr         
                85                  90                  95              

ggc tct cag gct ggt gtg ctc acc acc gag cgc cac gga aac gca cgc      336
Gly Ser Gln Ala Gly Val Leu Thr Thr Glu Arg His Gly Asn Ala Arg         
            100                 105                 110                 

att gtt gat gtc act cca ggt cgt gtg cgt gaa gca ctc gat gag ggc      384
Ile Val Asp Val Thr Pro Gly Arg Val Arg Glu Ala Leu Asp Glu Gly         
        115                 120                 125                     

aag atc tgc att gtt gct ggt ttc cag ggt gtt aat aaa gaa acc cgc      432
Lys Ile Cys Ile Val Ala Gly Phe Gln Gly Val Asn Lys Glu Thr Arg         
    130                 135                 140                         

gat gtc acc acg ttg ggt cgt ggt ggt tct gac acc act gca gtt gcg      480
Asp Val Thr Thr Leu Gly Arg Gly Gly Ser Asp Thr Thr Ala Val Ala         
145                 150                 155                 160         

ttg gca gct gct ttg aac gct gat gtg tgt gag att tac tcg gac gtt      528
Leu Ala Ala Ala Leu Asn Ala Asp Val Cys Glu Ile Tyr Ser Asp Val         
                165                 170                 175             

gac ggt gtg tat acc gct gac ccg cgc atc gtt cct aat gca cag aag      576
Asp Gly Val Tyr Thr Ala Asp Pro Arg Ile Val Pro Asn Ala Gln Lys         
            180                 185                 190                 

ctg gaa aag ctc agc ttc gaa gaa atg ctg gaa ctt gct gct gtt ggc      624
Leu Glu Lys Leu Ser Phe Glu Glu Met Leu Glu Leu Ala Ala Val Gly         
        195                 200                 205                     

tcc aag att ttg gtg ctg cgc agt gtt gaa tac gct cgt gca ttc aat      672
Ser Lys Ile Leu Val Leu Arg Ser Val Glu Tyr Ala Arg Ala Phe Asn         
    210                 215                 220                         

gtg cca ctt cgc gta cgc tcg tct tat agt aat gat ccc ggc act ttg      720
Val Pro Leu Arg Val Arg Ser Ser Tyr Ser Asn Asp Pro Gly Thr Leu         
225                 230                 235                 240         

att gcc ggc tct atg gag gat att cct gtg gaa gaa gca gtc ctt acc      768
Ile Ala Gly Ser Met Glu Asp Ile Pro Val Glu Glu Ala Val Leu Thr         
                245                 250                 255             

ggt gtc gca acc gac aag tcc gaa gcc aaa gta acc gtt ctg ggt att      816
Gly Val Ala Thr Asp Lys Ser Glu Ala Lys Val Thr Val Leu Gly Ile         
            260                 265                 270                 

tcc gat aag cca ggc gag gct gcg aag gtt ttc cgt gcg ttg gct gat      864
Ser Asp Lys Pro Gly Glu Ala Ala Lys Val Phe Arg Ala Leu Ala Asp         
        275                 280                 285                     

gca gaa atc aac att gac atg gtt ctg cag aac gtc tct tct gta gaa      912
Ala Glu Ile Asn Ile Asp Met Val Leu Gln Asn Val Ser Ser Val Glu         
    290                 295                 300                         

gac ggc acc acc gac atc acc ttc acc tgc cct cgt tcc gac ggc cgc      960
Asp Gly Thr Thr Asp Ile Thr Phe Thr Cys Pro Arg Ser Asp Gly Arg         
305                 310                 315                 320         

cgc gcg atg gag atc ttg aag aag ctt cag gtt cag ggc aac tgg acc     1008
Arg Ala Met Glu Ile Leu Lys Lys Leu Gln Val Gln Gly Asn Trp Thr         
                325                 330                 335             

aat gtg ctt tac gac gac cag gtc ggc aaa gtc tcc ctc gtg ggt gct     1056
Asn Val Leu Tyr Asp Asp Gln Val Gly Lys Val Ser Leu Val Gly Ala         
            340                 345                 350                 

ggc atg aag tct cac cca ggt gtt acc gca gag ttc atg gaa gct ctg     1104
Gly Met Lys Ser His Pro Gly Val Thr Ala Glu Phe Met Glu Ala Leu         
        355                 360                 365                     

cgc gat gtc aac gtg aac atc gaa ttg att tcc acc tct gag att cgt     1152
Arg Asp Val Asn Val Asn Ile Glu Leu Ile Ser Thr Ser Glu Ile Arg         
    370                 375                 380                         

att tcc gtg ctg atc cgt gaa gat gat ctg gat gct gct gca cgt gca     1200
Ile Ser Val Leu Ile Arg Glu Asp Asp Leu Asp Ala Ala Ala Arg Ala         
385                 390                 395                 400         

ttg cat gag cag ttc cag ctg ggc ggc gaa gac gaa gcc gtc gtt tat     1248
Leu His Glu Gln Phe Gln Leu Gly Gly Glu Asp Glu Ala Val Val Tyr         
                405                 410                 415             

gca ggc acc gga cgc                                                 1263
Ala Gly Thr Gly Arg                                                     
            420                                                         


<210>  12
<211>  421
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  12

Met Ala Leu Val Val Gln Lys Tyr Gly Gly Ser Ser Leu Glu Ser Ala 
1               5                   10                  15      


Glu Arg Ile Arg Asn Val Ala Glu Arg Ile Val Ala Thr Lys Lys Ala 
            20                  25                  30          


Gly Asn Asp Val Val Val Val Cys Ser Ala Met Gly Asp Thr Thr Asp 
        35                  40                  45              


Glu Leu Leu Glu Leu Ala Ala Ala Val Asn Pro Val Pro Pro Ala Arg 
    50                  55                  60                  


Glu Met Asp Met Leu Leu Thr Ala Gly Glu Arg Ile Ser Asn Ala Leu 
65                  70                  75                  80  


Val Ala Met Ala Ile Glu Ser Leu Gly Ala Glu Ala Gln Ser Phe Thr 
                85                  90                  95      


Gly Ser Gln Ala Gly Val Leu Thr Thr Glu Arg His Gly Asn Ala Arg 
            100                 105                 110         


Ile Val Asp Val Thr Pro Gly Arg Val Arg Glu Ala Leu Asp Glu Gly 
        115                 120                 125             


Lys Ile Cys Ile Val Ala Gly Phe Gln Gly Val Asn Lys Glu Thr Arg 
    130                 135                 140                 


Asp Val Thr Thr Leu Gly Arg Gly Gly Ser Asp Thr Thr Ala Val Ala 
145                 150                 155                 160 


Leu Ala Ala Ala Leu Asn Ala Asp Val Cys Glu Ile Tyr Ser Asp Val 
                165                 170                 175     


Asp Gly Val Tyr Thr Ala Asp Pro Arg Ile Val Pro Asn Ala Gln Lys 
            180                 185                 190         


Leu Glu Lys Leu Ser Phe Glu Glu Met Leu Glu Leu Ala Ala Val Gly 
        195                 200                 205             


Ser Lys Ile Leu Val Leu Arg Ser Val Glu Tyr Ala Arg Ala Phe Asn 
    210                 215                 220                 


Val Pro Leu Arg Val Arg Ser Ser Tyr Ser Asn Asp Pro Gly Thr Leu 
225                 230                 235                 240 


Ile Ala Gly Ser Met Glu Asp Ile Pro Val Glu Glu Ala Val Leu Thr 
                245                 250                 255     


Gly Val Ala Thr Asp Lys Ser Glu Ala Lys Val Thr Val Leu Gly Ile 
            260                 265                 270         


Ser Asp Lys Pro Gly Glu Ala Ala Lys Val Phe Arg Ala Leu Ala Asp 
        275                 280                 285             


Ala Glu Ile Asn Ile Asp Met Val Leu Gln Asn Val Ser Ser Val Glu 
    290                 295                 300                 


Asp Gly Thr Thr Asp Ile Thr Phe Thr Cys Pro Arg Ser Asp Gly Arg 
305                 310                 315                 320 


Arg Ala Met Glu Ile Leu Lys Lys Leu Gln Val Gln Gly Asn Trp Thr 
                325                 330                 335     


Asn Val Leu Tyr Asp Asp Gln Val Gly Lys Val Ser Leu Val Gly Ala 
            340                 345                 350         


Gly Met Lys Ser His Pro Gly Val Thr Ala Glu Phe Met Glu Ala Leu 
        355                 360                 365             


Arg Asp Val Asn Val Asn Ile Glu Leu Ile Ser Thr Ser Glu Ile Arg 
    370                 375                 380                 


Ile Ser Val Leu Ile Arg Glu Asp Asp Leu Asp Ala Ala Ala Arg Ala 
385                 390                 395                 400 


Leu His Glu Gln Phe Gln Leu Gly Gly Glu Asp Glu Ala Val Val Tyr 
                405                 410                 415     


Ala Gly Thr Gly Arg 
            420     


<210>  13
<211>  1633
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  misc_feature
<222>  (1)..(2)

<220>
<221>  misc_feature
<222>  (1)..(1633)
<223>  PCR-Produkt

<220>
<221>  misc_structure
<222>  (3)..(8)
<223>  EcoRI-Restriktionsschnittstelle

<220>
<221>  CDS
<222>  (99)..(1592)

<220>
<221>  mutation
<222>  (913)..(913)
<223>  C -> T Transition

<220>
<221>  misc_structure
<222>  (1626)..(1631)
<223>  EcoRI-Restriktionsschnittstelle

<220>
<221>  misc_feature
<222>  (1632)..(1633)

<400>  13
gcgaattcta aactgcgtga ggttgtggcc tgtcacacat aatcggccta gggtgggact     60

ttaaggaaac agtgcacaaa taaatctcaa ggagcccc atg cgc atc cac gat gtt    116
                                          Met Arg Ile His Asp Val       
                                          1               5             

tat acc cac ctt tcg gcc gat aac ttt ccc aaa gca gag cac ctt gcg      164
Tyr Thr His Leu Ser Ala Asp Asn Phe Pro Lys Ala Glu His Leu Ala         
            10                  15                  20                  

tgg aaa ttc tcc gag ctt gcc acc gac ccc gtg gag gtg aca ccg gat      212
Trp Lys Phe Ser Glu Leu Ala Thr Asp Pro Val Glu Val Thr Pro Asp         
        25                  30                  35                      

gtt tcg gag atg atc atc aac cgg atc atc gac aac gcg gcg gtg tct      260
Val Ser Glu Met Ile Ile Asn Arg Ile Ile Asp Asn Ala Ala Val Ser         
    40                  45                  50                          

gcc gcg tcg gtg ttg cgc cgg cct gtg act gtg gcc agg caa caa gcg      308
Ala Ala Ser Val Leu Arg Arg Pro Val Thr Val Ala Arg Gln Gln Ala         
55                  60                  65                  70          

cag tcc cat ccg cgg gaa aag ggc gga aaa gtt ttt gga att tca ggc      356
Gln Ser His Pro Arg Glu Lys Gly Gly Lys Val Phe Gly Ile Ser Gly         
                75                  80                  85              

agc tac tca cca gag tgg gct gcc ttt gct aat ggt gtg gcc gta cgt      404
Ser Tyr Ser Pro Glu Trp Ala Ala Phe Ala Asn Gly Val Ala Val Arg         
            90                  95                  100                 

gaa ttg gac ttc cac gat aca ttt tta gca gct gaa tac tcc cat ccc      452
Glu Leu Asp Phe His Asp Thr Phe Leu Ala Ala Glu Tyr Ser His Pro         
        105                 110                 115                     

ggc gac aat att cca cca ctt ctt gca gta gcg cag gct cag aga agc      500
Gly Asp Asn Ile Pro Pro Leu Leu Ala Val Ala Gln Ala Gln Arg Ser         
    120                 125                 130                         

agc ggc agg gat ctc att cgg ggt atc gcc act gcc tat gag gtg cag      548
Ser Gly Arg Asp Leu Ile Arg Gly Ile Ala Thr Ala Tyr Glu Val Gln         
135                 140                 145                 150         

gtg gaa ttg gtg agg ggg atc tgc ttg cat gag cac aaa att gat cac      596
Val Glu Leu Val Arg Gly Ile Cys Leu His Glu His Lys Ile Asp His         
                155                 160                 165             

gta gcc cac ctt ggt ccc agc gct gca gcg ggt ttg ggc acg ttg ttg      644
Val Ala His Leu Gly Pro Ser Ala Ala Ala Gly Leu Gly Thr Leu Leu         
            170                 175                 180                 

cat gta gat gag gaa acc atc tac cag gcg atc ggc cag gca ttg cac      692
His Val Asp Glu Glu Thr Ile Tyr Gln Ala Ile Gly Gln Ala Leu His         
        185                 190                 195                     

acc acg acg gct acg agg cag tcg cga aaa ggt gag att tcc agc tgg      740
Thr Thr Thr Ala Thr Arg Gln Ser Arg Lys Gly Glu Ile Ser Ser Trp         
    200                 205                 210                         

aag gcg ttc gcg cca gcg ttt gcg gga aag atg gcc att gag gcg atg      788
Lys Ala Phe Ala Pro Ala Phe Ala Gly Lys Met Ala Ile Glu Ala Met         
215                 220                 225                 230         

gat cgt gcg atg cgt ggg gag ggt tcg ccc gca ccg att tgg gag ggc      836
Asp Arg Ala Met Arg Gly Glu Gly Ser Pro Ala Pro Ile Trp Glu Gly         
                235                 240                 245             

gaa gac ggg gtc atc gcg tgg ctg tta tcg ggc aaa gat cat gtt tat      884
Glu Asp Gly Val Ile Ala Trp Leu Leu Ser Gly Lys Asp His Val Tyr         
            250                 255                 260                 

cat gtg cca ttg ccg gaa cac ggc gag ctc aag ctg ggg att cta gag      932
His Val Pro Leu Pro Glu His Gly Glu Leu Lys Leu Gly Ile Leu Glu         
        265                 270                 275                     

act tac aca aag gaa cat tca gcg gaa tat caa tcg cag gca ccg att      980
Thr Tyr Thr Lys Glu His Ser Ala Glu Tyr Gln Ser Gln Ala Pro Ile         
    280                 285                 290                         

gat ctg gcg cgc agg atg aag cca ctg gtt gac gcg gct ggc gga acg     1028
Asp Leu Ala Arg Arg Met Lys Pro Leu Val Asp Ala Ala Gly Gly Thr         
295                 300                 305                 310         

gaa cac att gca gag att gtg ctg cgc acc agt cac cac acg cat tat     1076
Glu His Ile Ala Glu Ile Val Leu Arg Thr Ser His His Thr His Tyr         
                315                 320                 325             

gtg att ggc act ggg gcg aac gat ccg cag aag atg gat ccg cag gcc     1124
Val Ile Gly Thr Gly Ala Asn Asp Pro Gln Lys Met Asp Pro Gln Ala         
            330                 335                 340                 

tcg cgt gaa acc ctg gat cat tcc atc atg tac att ttc gcc gtc gcg     1172
Ser Arg Glu Thr Leu Asp His Ser Ile Met Tyr Ile Phe Ala Val Ala         
        345                 350                 355                     

ctt caa gat ggc gtg tgg cac cac gag ttt tcc tac acc cgc aag cgt     1220
Leu Gln Asp Gly Val Trp His His Glu Phe Ser Tyr Thr Arg Lys Arg         
    360                 365                 370                         

tcc acc cgc ccg gaa act gtg gag ctg tgg cac aag att cgc acc gtg     1268
Ser Thr Arg Pro Glu Thr Val Glu Leu Trp His Lys Ile Arg Thr Val         
375                 380                 385                 390         

gag gat cct gaa tgg acg cgc cga tac cat tct gat gat cct gca aaa     1316
Glu Asp Pro Glu Trp Thr Arg Arg Tyr His Ser Asp Asp Pro Ala Lys         
                395                 400                 405             

aag gcc ttt ggt gcg aaa gca gtg atc aca atg gct gat ggc acc gtg     1364
Lys Ala Phe Gly Ala Lys Ala Val Ile Thr Met Ala Asp Gly Thr Val         
            410                 415                 420                 

att gag gat gaa ttg gct gtc gcg gat gcc cac ccg ctg ggt gct cgg     1412
Ile Glu Asp Glu Leu Ala Val Ala Asp Ala His Pro Leu Gly Ala Arg         
        425                 430                 435                     

ccg ttt gcg cgg gag aat tac att gaa aaa ttc cgc aca ctc gcg cag     1460
Pro Phe Ala Arg Glu Asn Tyr Ile Glu Lys Phe Arg Thr Leu Ala Gln         
    440                 445                 450                         

ggg att gtc att gat tca gaa cag gaa cgc ttc ttg cat gcc gtg caa     1508
Gly Ile Val Ile Asp Ser Glu Gln Glu Arg Phe Leu His Ala Val Gln         
455                 460                 465                 470         

agc ctg cct gac ctg gat gat ctt gat cag ctc aac atc gaa gtc gac     1556
Ser Leu Pro Asp Leu Asp Asp Leu Asp Gln Leu Asn Ile Glu Val Asp         
                475                 480                 485             

ata agc aac cag gcc gcg acg aaa gcg ggg ctg tta tgaatctctt          1602
Ile Ser Asn Gln Ala Ala Thr Lys Ala Gly Leu Leu                         
            490                 495                                     

ttcgaatggt gttgatgtgg ggagaattcg c                                  1633


<210>  14
<211>  498
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  14

Met Arg Ile His Asp Val Tyr Thr His Leu Ser Ala Asp Asn Phe Pro 
1               5                   10                  15      


Lys Ala Glu His Leu Ala Trp Lys Phe Ser Glu Leu Ala Thr Asp Pro 
            20                  25                  30          


Val Glu Val Thr Pro Asp Val Ser Glu Met Ile Ile Asn Arg Ile Ile 
        35                  40                  45              


Asp Asn Ala Ala Val Ser Ala Ala Ser Val Leu Arg Arg Pro Val Thr 
    50                  55                  60                  


Val Ala Arg Gln Gln Ala Gln Ser His Pro Arg Glu Lys Gly Gly Lys 
65                  70                  75                  80  


Val Phe Gly Ile Ser Gly Ser Tyr Ser Pro Glu Trp Ala Ala Phe Ala 
                85                  90                  95      


Asn Gly Val Ala Val Arg Glu Leu Asp Phe His Asp Thr Phe Leu Ala 
            100                 105                 110         


Ala Glu Tyr Ser His Pro Gly Asp Asn Ile Pro Pro Leu Leu Ala Val 
        115                 120                 125             


Ala Gln Ala Gln Arg Ser Ser Gly Arg Asp Leu Ile Arg Gly Ile Ala 
    130                 135                 140                 


Thr Ala Tyr Glu Val Gln Val Glu Leu Val Arg Gly Ile Cys Leu His 
145                 150                 155                 160 


Glu His Lys Ile Asp His Val Ala His Leu Gly Pro Ser Ala Ala Ala 
                165                 170                 175     


Gly Leu Gly Thr Leu Leu His Val Asp Glu Glu Thr Ile Tyr Gln Ala 
            180                 185                 190         


Ile Gly Gln Ala Leu His Thr Thr Thr Ala Thr Arg Gln Ser Arg Lys 
        195                 200                 205             


Gly Glu Ile Ser Ser Trp Lys Ala Phe Ala Pro Ala Phe Ala Gly Lys 
    210                 215                 220                 


Met Ala Ile Glu Ala Met Asp Arg Ala Met Arg Gly Glu Gly Ser Pro 
225                 230                 235                 240 


Ala Pro Ile Trp Glu Gly Glu Asp Gly Val Ile Ala Trp Leu Leu Ser 
                245                 250                 255     


Gly Lys Asp His Val Tyr His Val Pro Leu Pro Glu His Gly Glu Leu 
            260                 265                 270         


Lys Leu Gly Ile Leu Glu Thr Tyr Thr Lys Glu His Ser Ala Glu Tyr 
        275                 280                 285             


Gln Ser Gln Ala Pro Ile Asp Leu Ala Arg Arg Met Lys Pro Leu Val 
    290                 295                 300                 


Asp Ala Ala Gly Gly Thr Glu His Ile Ala Glu Ile Val Leu Arg Thr 
305                 310                 315                 320 


Ser His His Thr His Tyr Val Ile Gly Thr Gly Ala Asn Asp Pro Gln 
                325                 330                 335     


Lys Met Asp Pro Gln Ala Ser Arg Glu Thr Leu Asp His Ser Ile Met 
            340                 345                 350         


Tyr Ile Phe Ala Val Ala Leu Gln Asp Gly Val Trp His His Glu Phe 
        355                 360                 365             


Ser Tyr Thr Arg Lys Arg Ser Thr Arg Pro Glu Thr Val Glu Leu Trp 
    370                 375                 380                 


His Lys Ile Arg Thr Val Glu Asp Pro Glu Trp Thr Arg Arg Tyr His 
385                 390                 395                 400 


Ser Asp Asp Pro Ala Lys Lys Ala Phe Gly Ala Lys Ala Val Ile Thr 
                405                 410                 415     


Met Ala Asp Gly Thr Val Ile Glu Asp Glu Leu Ala Val Ala Asp Ala 
            420                 425                 430         


His Pro Leu Gly Ala Arg Pro Phe Ala Arg Glu Asn Tyr Ile Glu Lys 
        435                 440                 445             


Phe Arg Thr Leu Ala Gln Gly Ile Val Ile Asp Ser Glu Gln Glu Arg 
    450                 455                 460                 


Phe Leu His Ala Val Gln Ser Leu Pro Asp Leu Asp Asp Leu Asp Gln 
465                 470                 475                 480 


Leu Asn Ile Glu Val Asp Ile Ser Asn Gln Ala Ala Thr Lys Ala Gly 
                485                 490                 495     


Leu Leu 
        


<210>  15
<211>  1311
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(1308)
<223>  ilvA-Wildtyp-Gen

<400>  15
atg agt gaa aca tac gtg tct gag aaa agt cca gga gtg atg gct agc       48
Met Ser Glu Thr Tyr Val Ser Glu Lys Ser Pro Gly Val Met Ala Ser         
1               5                   10                  15              

gga gcg gag ctg att cgt gcc gcc gac att caa acg gcg cag gca cga       96
Gly Ala Glu Leu Ile Arg Ala Ala Asp Ile Gln Thr Ala Gln Ala Arg         
            20                  25                  30                  

att tcc tcc gtc att gca cca act cca ttg cag tat tgc cct cgt ctt      144
Ile Ser Ser Val Ile Ala Pro Thr Pro Leu Gln Tyr Cys Pro Arg Leu         
        35                  40                  45                      

tct gag gaa acc gga gcg gaa atc tac ctt aag cgt gag gat ctg cag      192
Ser Glu Glu Thr Gly Ala Glu Ile Tyr Leu Lys Arg Glu Asp Leu Gln         
    50                  55                  60                          

gat gtt cgt tcc tac aag atc cgc ggt gcg ctg aac tct gga gcg cag      240
Asp Val Arg Ser Tyr Lys Ile Arg Gly Ala Leu Asn Ser Gly Ala Gln         
65                  70                  75                  80          

ctc acc caa gag cag cgc gat gca ggt atc gtt gcc gca tct gca ggt      288
Leu Thr Gln Glu Gln Arg Asp Ala Gly Ile Val Ala Ala Ser Ala Gly         
                85                  90                  95              

aac cat gcc cag ggc gtg gcc tat gtg tgc aag tcc ttg ggc gtt cag      336
Asn His Ala Gln Gly Val Ala Tyr Val Cys Lys Ser Leu Gly Val Gln         
            100                 105                 110                 

gga cgc atc tat gtt cct gtg cag act cca aag caa aag cgt gac cgc      384
Gly Arg Ile Tyr Val Pro Val Gln Thr Pro Lys Gln Lys Arg Asp Arg         
        115                 120                 125                     

atc atg gtt cac ggc gga gag ttt gtc tcc ttg gtg gtc act ggc aat      432
Ile Met Val His Gly Gly Glu Phe Val Ser Leu Val Val Thr Gly Asn         
    130                 135                 140                         

aac ttc gac gaa gca tcg gct gca gcg cat gaa gat gca gag cgc acc      480
Asn Phe Asp Glu Ala Ser Ala Ala Ala His Glu Asp Ala Glu Arg Thr         
145                 150                 155                 160         

ggc gca acg ctg atc gag cct ttc gat gct cgc aac acc gtc atc ggt      528
Gly Ala Thr Leu Ile Glu Pro Phe Asp Ala Arg Asn Thr Val Ile Gly         
                165                 170                 175             

cag ggc acc gtg gct gct gag atc ttg tcg cag ctg act tcc atg ggc      576
Gln Gly Thr Val Ala Ala Glu Ile Leu Ser Gln Leu Thr Ser Met Gly         
            180                 185                 190                 

aag agt gca gat cac gtg atg gtt cca gtc ggc ggt ggc gga ctt ctt      624
Lys Ser Ala Asp His Val Met Val Pro Val Gly Gly Gly Gly Leu Leu         
        195                 200                 205                     

gca ggt gtg gtc agc tac atg gct gat atg gca cct cgc act gcg atc      672
Ala Gly Val Val Ser Tyr Met Ala Asp Met Ala Pro Arg Thr Ala Ile         
    210                 215                 220                         

gtt ggt atc gaa cca gcg gga gca gca tcc atg cag gct gca ttg cac      720
Val Gly Ile Glu Pro Ala Gly Ala Ala Ser Met Gln Ala Ala Leu His         
225                 230                 235                 240         

aat ggt gga cca atc act ttg gag act gtt gat ccc ttt gtg gac ggc      768
Asn Gly Gly Pro Ile Thr Leu Glu Thr Val Asp Pro Phe Val Asp Gly         
                245                 250                 255             

gca gca gtc aaa cgt gtc gga gat ctc aac tac acc atc gtg gag aag      816
Ala Ala Val Lys Arg Val Gly Asp Leu Asn Tyr Thr Ile Val Glu Lys         
            260                 265                 270                 

aac cag ggt cgc gtg cac atg atg agc gcg acc gag ggc gct gtg tgt      864
Asn Gln Gly Arg Val His Met Met Ser Ala Thr Glu Gly Ala Val Cys         
        275                 280                 285                     

act gag atg ctc gat ctt tac caa aac gaa ggc atc atc gcg gag cct      912
Thr Glu Met Leu Asp Leu Tyr Gln Asn Glu Gly Ile Ile Ala Glu Pro         
    290                 295                 300                         

gct ggc gcg ctg tct atc gct ggg ttg aag gaa atg tcc ttt gca cct      960
Ala Gly Ala Leu Ser Ile Ala Gly Leu Lys Glu Met Ser Phe Ala Pro         
305                 310                 315                 320         

ggt tct gtc gtg gtg tgc atc atc tct ggt ggc aac aac gat gtg ctg     1008
Gly Ser Val Val Val Cys Ile Ile Ser Gly Gly Asn Asn Asp Val Leu         
                325                 330                 335             

cgt tat gcg gaa atc gct gag cgc tcc ttg gtg cac cgc ggt ttg aag     1056
Arg Tyr Ala Glu Ile Ala Glu Arg Ser Leu Val His Arg Gly Leu Lys         
            340                 345                 350                 

cac tac ttc ttg gtg aac ttc ccg caa aag cct ggt cag ttg cgt cac     1104
His Tyr Phe Leu Val Asn Phe Pro Gln Lys Pro Gly Gln Leu Arg His         
        355                 360                 365                     

ttc ctg gaa gat atc ctg gga ccg gat gat gac atc acg ctg ttt gag     1152
Phe Leu Glu Asp Ile Leu Gly Pro Asp Asp Asp Ile Thr Leu Phe Glu         
    370                 375                 380                         

tac ctc aag cgc aac aac cgt gag acc ggt act gcg ttg gtg ggt att     1200
Tyr Leu Lys Arg Asn Asn Arg Glu Thr Gly Thr Ala Leu Val Gly Ile         
385                 390                 395                 400         

cac ttg agt gaa gca tca gga ttg gat tct ttg ctg gaa cgt atg gag     1248
His Leu Ser Glu Ala Ser Gly Leu Asp Ser Leu Leu Glu Arg Met Glu         
                405                 410                 415             

gaa tcg gca att gat tcc cgt cgc ctc gag ccg ggc acc cct gag tac     1296
Glu Ser Ala Ile Asp Ser Arg Arg Leu Glu Pro Gly Thr Pro Glu Tyr         
            420                 425                 430                 

gaa tac ttg acc taa                                                 1311
Glu Tyr Leu Thr                                                         
        435                                                             


<210>  16
<211>  436
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  16

Met Ser Glu Thr Tyr Val Ser Glu Lys Ser Pro Gly Val Met Ala Ser 
1               5                   10                  15      


Gly Ala Glu Leu Ile Arg Ala Ala Asp Ile Gln Thr Ala Gln Ala Arg 
            20                  25                  30          


Ile Ser Ser Val Ile Ala Pro Thr Pro Leu Gln Tyr Cys Pro Arg Leu 
        35                  40                  45              


Ser Glu Glu Thr Gly Ala Glu Ile Tyr Leu Lys Arg Glu Asp Leu Gln 
    50                  55                  60                  


Asp Val Arg Ser Tyr Lys Ile Arg Gly Ala Leu Asn Ser Gly Ala Gln 
65                  70                  75                  80  


Leu Thr Gln Glu Gln Arg Asp Ala Gly Ile Val Ala Ala Ser Ala Gly 
                85                  90                  95      


Asn His Ala Gln Gly Val Ala Tyr Val Cys Lys Ser Leu Gly Val Gln 
            100                 105                 110         


Gly Arg Ile Tyr Val Pro Val Gln Thr Pro Lys Gln Lys Arg Asp Arg 
        115                 120                 125             


Ile Met Val His Gly Gly Glu Phe Val Ser Leu Val Val Thr Gly Asn 
    130                 135                 140                 


Asn Phe Asp Glu Ala Ser Ala Ala Ala His Glu Asp Ala Glu Arg Thr 
145                 150                 155                 160 


Gly Ala Thr Leu Ile Glu Pro Phe Asp Ala Arg Asn Thr Val Ile Gly 
                165                 170                 175     


Gln Gly Thr Val Ala Ala Glu Ile Leu Ser Gln Leu Thr Ser Met Gly 
            180                 185                 190         


Lys Ser Ala Asp His Val Met Val Pro Val Gly Gly Gly Gly Leu Leu 
        195                 200                 205             


Ala Gly Val Val Ser Tyr Met Ala Asp Met Ala Pro Arg Thr Ala Ile 
    210                 215                 220                 


Val Gly Ile Glu Pro Ala Gly Ala Ala Ser Met Gln Ala Ala Leu His 
225                 230                 235                 240 


Asn Gly Gly Pro Ile Thr Leu Glu Thr Val Asp Pro Phe Val Asp Gly 
                245                 250                 255     


Ala Ala Val Lys Arg Val Gly Asp Leu Asn Tyr Thr Ile Val Glu Lys 
            260                 265                 270         


Asn Gln Gly Arg Val His Met Met Ser Ala Thr Glu Gly Ala Val Cys 
        275                 280                 285             


Thr Glu Met Leu Asp Leu Tyr Gln Asn Glu Gly Ile Ile Ala Glu Pro 
    290                 295                 300                 


Ala Gly Ala Leu Ser Ile Ala Gly Leu Lys Glu Met Ser Phe Ala Pro 
305                 310                 315                 320 


Gly Ser Val Val Val Cys Ile Ile Ser Gly Gly Asn Asn Asp Val Leu 
                325                 330                 335     


Arg Tyr Ala Glu Ile Ala Glu Arg Ser Leu Val His Arg Gly Leu Lys 
            340                 345                 350         


His Tyr Phe Leu Val Asn Phe Pro Gln Lys Pro Gly Gln Leu Arg His 
        355                 360                 365             


Phe Leu Glu Asp Ile Leu Gly Pro Asp Asp Asp Ile Thr Leu Phe Glu 
    370                 375                 380                 


Tyr Leu Lys Arg Asn Asn Arg Glu Thr Gly Thr Ala Leu Val Gly Ile 
385                 390                 395                 400 


His Leu Ser Glu Ala Ser Gly Leu Asp Ser Leu Leu Glu Arg Met Glu 
                405                 410                 415     


Glu Ser Ala Ile Asp Ser Arg Arg Leu Glu Pro Gly Thr Pro Glu Tyr 
            420                 425                 430         


Glu Tyr Leu Thr 
        435     


<210>  17
<211>  120
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(120)
<223>  Teil der Kodierregion des prpD1-Allels

<220>
<221>  misc_feature
<222>  (61)..(63)
<223>  n is a, c, g, or t

<400>  17
gcg tgg ctg tta tcg ggc aaa gat cat gtt tat cat gtg cca ttg ccg       48
Ala Trp Leu Leu Ser Gly Lys Asp His Val Tyr His Val Pro Leu Pro         
1               5                   10                  15              

gaa cac ggc gag nnn aag ctg ggg att cta gag act tac aca aag gaa       96
Glu His Gly Glu Xaa Lys Leu Gly Ile Leu Glu Thr Tyr Thr Lys Glu         
            20                  25                  30                  

cat tca gcg gaa tat caa tcg cag                                      120
His Ser Ala Glu Tyr Gln Ser Gln                                         
        35                  40                                          


<210>  18
<211>  40
<212>  PRT
<213>  Corynebacterium glutamicum

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  The 'Xaa' at location 21 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Leu, Tyr, Trp, Cys, 
       or Phe.

<400>  18

Ala Trp Leu Leu Ser Gly Lys Asp His Val Tyr His Val Pro Leu Pro 
1               5                   10                  15      


Glu His Gly Glu Xaa Lys Leu Gly Ile Leu Glu Thr Tyr Thr Lys Glu 
            20                  25                  30          


His Ser Ala Glu Tyr Gln Ser Gln 
        35                  40  


<210>  19
<211>  120
<212>  DNA
<213>  Corynebacterium glutamicum


<220>
<221>  CDS
<222>  (1)..(120)
<223>  Teil der Kodierregion des prpD1-Allels

<400>  19
gcg tgg ctg tta tcg ggc aaa gat cat gtt tat cat gtg cca ttg ccg       48
Ala Trp Leu Leu Ser Gly Lys Asp His Val Tyr His Val Pro Leu Pro         
1               5                   10                  15              

gaa cac ggc gag ctc aag ctg ggg att cta gag act tac aca aag gaa       96
Glu His Gly Glu Leu Lys Leu Gly Ile Leu Glu Thr Tyr Thr Lys Glu         
            20                  25                  30                  

cat tca gcg gaa tat caa tcg cag                                      120
His Ser Ala Glu Tyr Gln Ser Gln                                         
        35                  40                                          


<210>  20
<211>  40
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  20

Ala Trp Leu Leu Ser Gly Lys Asp His Val Tyr His Val Pro Leu Pro 
1               5                   10                  15      


Glu His Gly Glu Leu Lys Leu Gly Ile Leu Glu Thr Tyr Thr Lys Glu 
            20                  25                  30          


His Ser Ala Glu Tyr Gln Ser Gln 
        35                  40  

		