
                                SEQUENCE LISTING

<110> Wyeth

<120> COMPOSITIONS AND METHODS FOR MODULATING
  TLR14 ACTIVITY

<130> 16158-116WO1

<150> GB 0620695.7        
<151> 2006-10-18  

<160> 16

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2436
<212> DNA
<213> Homo sapiens

<400> 1
atggaggctg cccgcgcctt gcgcctcctg ctcgtggtgt gcggctgcct cgcgctcccg 60
ccgctggccg agcccgtgtg cccggagcgc tgcgactgcc agcatcccca gcatctcctg 120
tgcaccaaca gggggctccg cgtagtgccc aagaccagct cgctgccgag cccccacgac 180
gtgctcacct acagcctcgg cggcaacttc ataaccaaca tcacggcctt cgacttccac 240
cgtctggggc agctcagacg gctggacctg cagtacaacc agatccgctc tctgcacccc 300
aagaccttcg agaagctctc gcggctggaa gagctgtacc tggggaacaa cctcttgcag 360
gcgctcgccc cgggcacgct ggccccgctg cgcaagctgc gcatcctcta cgccaacggg 420
aacgagatca gccgcctaag ccgcggctcc ttcgagggcc tggagagtct agtcaagctg 480
cggctggacg ggaacgccct gggggcgctg ccggacgcgg tcttcgctcc cttgggcaac 540
ctgctctacc tacatctgga gtccaaccgg atccgctttc tgggcaagaa cgccttcgcc 600
cagctaggca agctgcgctt cctcaacctc tctgccaacg agctacagcc ctccctgcgc 660
cacgcggcca ccttcgcacc gctgcgctcc ctctcctccc tcatcctctc ggccaacagc 720
ctgcagcacc tcgggccgcg catcttccag cacctgccac gtctcggcct gctctcgctc 780
aggggcaacc agctcacgca cctcgcgcct gaggcctttt ggggcttgga ggccctgcgc 840
gagctgcgcc tggagggtaa tcggctgagc cagctgccaa ctgcgctgct ggagcctctg 900
cacagcctgg aggcgctgga cctgagcggc aatgagctgt ccgccctgca cccggccacc 960
ttcggccacc tgggccggct gcgcgagctc agcctgcgca acaacgcgct cagcgcccta 1020
tccggggaca tcttcgccgc cagcccagcc ctttatcggc tggatctaga cggcaacggc 1080
tggacctgcg actgccggct gcgaggcctg aagcgctgga tgggcgactg gcactcgcag 1140
ggccggctcc tcactgtctt cgtgcagtgt cgccaccccc cggccctgcg aggcaaatac 1200
ctggattacc tggatgacca gcagctgcaa aatggatcct gcgcggatcc ctcgccctca 1260
gcttccctga ccgctgaccg caggcggcag cccctaccca cggccgcagg ggaggagatg 1320
acgccacctg caggtctcgc ggaggagctg ccgccgcagc cgcagctcca gcagcagggg 1380
cgatttctag ctggggtggc ctgggatggg gccgccaggg agctggtagg caaccgcagc 1440
gctctaaggc tgagtcggcg gggcccgggc ctccagcagc ccagcccctc cgtcgctgcc 1500
gccgcgggcc cggctccaca gtccctagac ctgcacaaga agccccagcg gggccgtccg 1560
actcgggcag atcccgccct cgcggagccc accccaacgg cctctcctgg ctctgcgcca 1620
tcgcccgccg gcgacccctg gcagcgcgcg acgaagcatc gtctgggcac ggagcaccag 1680
gagcgtgccg cccagtccga cggtggggcc gggctgccgc cgctggtgtc cgacccatgc 1740
gacttcaaca agttcattct gtgcaacctg acggtggagg cggtgggcgc agacagcgcc 1800
tcggtgcgct gggccgtgcg cgagcaccgc agtccccggc cgctgggcgg cgcgcgcttc 1860
cgcctgctct ttgaccgctt tggccagcag cccaagttcc accgcttcgt ctacctgcct 1920
gagagcagcg actcggccac gctgcgcgag ctgcgcgggg acacccccta cctggtgtgc 1980
gtggagggcg tgcttggggg ccgtgtctgc cctgtggctc cccgggacca ctgcgcgggg 2040
ctggtcaccc taccggaggc cgggagccgg ggcggcgtcg actaccagct gctgaccttg 2100
gccctgctga cggtcaacgc gctgctggtg ctcctggcct tggcggcctg ggcgtctcgc 2160
tggctgcgta ggaaactgcg ggctaggcgg aagggcgggg ccccggtcca cgttcggcac 2220
atgtactcca cccgacggcc cctgcgctcc atgggcaccg gcgtgtccgc cgacttctcg 2280
ggattccagt cgcaccggcc acgcaccacc gtgtgcgcgc tcagtgaggc ggacctcatc 2340
gaattcccct gcgaccgctt catggacagt gcgggcggcg gcgcgggcgg cagcctgaga 2400
cgggaggacc gtctcctgca gcgatttgcc gactag                           2436

<210> 2
<211> 811
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Ala Ala Arg Ala Leu Arg Leu Leu Leu Val Val Cys Gly Cys
 1               5                  10                  15      
Leu Ala Leu Pro Pro Leu Ala Glu Pro Val Cys Pro Glu Arg Cys Asp
            20                  25                  30          
Cys Gln His Pro Gln His Leu Leu Cys Thr Asn Arg Gly Leu Arg Val
        35                  40                  45              
Val Pro Lys Thr Ser Ser Leu Pro Ser Pro His Asp Val Leu Thr Tyr
    50                  55                  60                  
Ser Leu Gly Gly Asn Phe Ile Thr Asn Ile Thr Ala Phe Asp Phe His
65                  70                  75                  80  
Arg Leu Gly Gln Leu Arg Arg Leu Asp Leu Gln Tyr Asn Gln Ile Arg
                85                  90                  95      
Ser Leu His Pro Lys Thr Phe Glu Lys Leu Ser Arg Leu Glu Glu Leu
            100                 105                 110         
Tyr Leu Gly Asn Asn Leu Leu Gln Ala Leu Ala Pro Gly Thr Leu Ala
        115                 120                 125             
Pro Leu Arg Lys Leu Arg Ile Leu Tyr Ala Asn Gly Asn Glu Ile Ser
    130                 135                 140                 
Arg Leu Ser Arg Gly Ser Phe Glu Gly Leu Glu Ser Leu Val Lys Leu
145                 150                 155                 160 
Arg Leu Asp Gly Asn Ala Leu Gly Ala Leu Pro Asp Ala Val Phe Ala
                165                 170                 175     
Pro Leu Gly Asn Leu Leu Tyr Leu His Leu Glu Ser Asn Arg Ile Arg
            180                 185                 190         
Phe Leu Gly Lys Asn Ala Phe Ala Gln Leu Gly Lys Leu Arg Phe Leu
        195                 200                 205             
Asn Leu Ser Ala Asn Glu Leu Gln Pro Ser Leu Arg His Ala Ala Thr
    210                 215                 220                 
Phe Ala Pro Leu Arg Ser Leu Ser Ser Leu Ile Leu Ser Ala Asn Ser
225                 230                 235                 240 
Leu Gln His Leu Gly Pro Arg Ile Phe Gln His Leu Pro Arg Leu Gly
                245                 250                 255     
Leu Leu Ser Leu Arg Gly Asn Gln Leu Thr His Leu Ala Pro Glu Ala
            260                 265                 270         
Phe Trp Gly Leu Glu Ala Leu Arg Glu Leu Arg Leu Glu Gly Asn Arg
        275                 280                 285             
Leu Ser Gln Leu Pro Thr Ala Leu Leu Glu Pro Leu His Ser Leu Glu
    290                 295                 300                 
Ala Leu Asp Leu Ser Gly Asn Glu Leu Ser Ala Leu His Pro Ala Thr
305                 310                 315                 320 
Phe Gly His Leu Gly Arg Leu Arg Glu Leu Ser Leu Arg Asn Asn Ala
                325                 330                 335     
Leu Ser Ala Leu Ser Gly Asp Ile Phe Ala Ala Ser Pro Ala Leu Tyr
            340                 345                 350         
Arg Leu Asp Leu Asp Gly Asn Gly Trp Thr Cys Asp Cys Arg Leu Arg
        355                 360                 365             
Gly Leu Lys Arg Trp Met Gly Asp Trp His Ser Gln Gly Arg Leu Leu
    370                 375                 380                 
Thr Val Phe Val Gln Cys Arg His Pro Pro Ala Leu Arg Gly Lys Tyr
385                 390                 395                 400 
Leu Asp Tyr Leu Asp Asp Gln Gln Leu Gln Asn Gly Ser Cys Ala Asp
                405                 410                 415     
Pro Ser Pro Ser Ala Ser Leu Thr Ala Asp Arg Arg Arg Gln Pro Leu
            420                 425                 430         
Pro Thr Ala Ala Gly Glu Glu Met Thr Pro Pro Ala Gly Leu Ala Glu
        435                 440                 445             
Glu Leu Pro Pro Gln Pro Gln Leu Gln Gln Gln Gly Arg Phe Leu Ala
    450                 455                 460                 
Gly Val Ala Trp Asp Gly Ala Ala Arg Glu Leu Val Gly Asn Arg Ser
465                 470                 475                 480 
Ala Leu Arg Leu Ser Arg Arg Gly Pro Gly Leu Gln Gln Pro Ser Pro
                485                 490                 495     
Ser Val Ala Ala Ala Ala Gly Pro Ala Pro Gln Ser Leu Asp Leu His
            500                 505                 510         
Lys Lys Pro Gln Arg Gly Arg Pro Thr Arg Ala Asp Pro Ala Leu Ala
        515                 520                 525             
Glu Pro Thr Pro Thr Ala Ser Pro Gly Ser Ala Pro Ser Pro Ala Gly
    530                 535                 540                 
Asp Pro Trp Gln Arg Ala Thr Lys His Arg Leu Gly Thr Glu His Gln
545                 550                 555                 560 
Glu Arg Ala Ala Gln Ser Asp Gly Gly Ala Gly Leu Pro Pro Leu Val
                565                 570                 575     
Ser Asp Pro Cys Asp Phe Asn Lys Phe Ile Leu Cys Asn Leu Thr Val
            580                 585                 590         
Glu Ala Val Gly Ala Asp Ser Ala Ser Val Arg Trp Ala Val Arg Glu
        595                 600                 605             
His Arg Ser Pro Arg Pro Leu Gly Gly Ala Arg Phe Arg Leu Leu Phe
    610                 615                 620                 
Asp Arg Phe Gly Gln Gln Pro Lys Phe His Arg Phe Val Tyr Leu Pro
625                 630                 635                 640 
Glu Ser Ser Asp Ser Ala Thr Leu Arg Glu Leu Arg Gly Asp Thr Pro
                645                 650                 655     
Tyr Leu Val Cys Val Glu Gly Val Leu Gly Gly Arg Val Cys Pro Val
            660                 665                 670         
Ala Pro Arg Asp His Cys Ala Gly Leu Val Thr Leu Pro Glu Ala Gly
        675                 680                 685             
Ser Arg Gly Gly Val Asp Tyr Gln Leu Leu Thr Leu Ala Leu Leu Thr
    690                 695                 700                 
Val Asn Ala Leu Leu Val Leu Leu Ala Leu Ala Ala Trp Ala Ser Arg
705                 710                 715                 720 
Trp Leu Arg Arg Lys Leu Arg Ala Arg Arg Lys Gly Gly Ala Pro Val
                725                 730                 735     
His Val Arg His Met Tyr Ser Thr Arg Arg Pro Leu Arg Ser Met Gly
            740                 745                 750         
Thr Gly Val Ser Ala Asp Phe Ser Gly Phe Gln Ser His Arg Pro Arg
        755                 760                 765             
Thr Thr Val Cys Ala Leu Ser Glu Ala Asp Leu Ile Glu Phe Pro Cys
    770                 775                 780                 
Asp Arg Phe Met Asp Ser Ala Gly Gly Gly Ala Gly Gly Ser Leu Arg
785                 790                 795                 800 
Arg Glu Asp Arg Leu Leu Gln Arg Phe Ala Asp
                805                 810     


<210> 3
<211> 2430
<212> DNA
<213> Mus musculus

<400> 3
atggagggtg tgggtgccgt gcgcttctgg ctcgtggtgt gcggctgcct ggcgttcccg 60
ccgcgggccg agtccgtgtg cccggagcgc tgcgactgcc agcaccccca acatctccta 120
tgcaccaaca ggggacttcg cgctgtaccc aagaccagct cgctgcctag tccccaggac 180
gtgctcacct acagcctagg cggcaacttc atcaccaaca tcaccgcctt cgacttccac 240
cgtctggggc agctcagacg gctggatctg cagtacaacc agatccgttc tctccacccc 300
aagaccttcg agaagctctc acgactagag gagctgtacc tggggaacaa cctcttgcag 360
gcgctcgttc ctggcacgtt ggctccgctg cgcaagttgc gcatccttta cgccaacggc 420
aacgagattg gacgcctgag tcgcgggtcc ttcgagggcc tggagagttt ggtcaagcta 480
cggctggacg ggaacgtgct gggagcgctg ccggacgcgg tcttcgctcc cctgggcaac 540
ctgctctacc tacacctgga atctaaccgg atccgttttt tgggcaagaa cgccttcagc 600
cagctgggta agcttcgatt cctcaatctc tcggccaacg agctgcaacc ctctctgcgc 660
cacgcggcca cctttgtccc tctgcgctcc ctctctactc tcatcctctc agccaacagc 720
ctacagcacc tcggcccccg cgtcttccag cacctgccac gcctaggcct gctctccctc 780
agtggaaacc agctcacgca cctcgcccca gaggcctttt ggggactgga ggccctacgt 840
gagctgcgcc tggaaggtaa ccggctgaac cagctccccc tgacactgct ggagcctctg 900
cacagcttgg aggcactaga cctgagtggc aatgagcttt ctgctctgca ccctgccacc 960
tttggccacc agggccggct ccgtgagctc agcctgcgcg acaacgcgct cagcgccctt 1020
tctggggaca tctttgccgc cagtccggct ctctaccggc tggatctaga cggcaatggt 1080
tggacctgcg actgccggtt gcggggtctg aaacgctgga tgggcaactg gcattctcag 1140
ggtcgcctcc ttacggtctt cgtgcagtgt cgccaccccc cggccctgcg gggcaagtac 1200
ctggattacc tggatgacca actgctgcag aatgggtctt gcgtggatcc ctcaccttcc 1260
cctacagcag gcagtaggca gtggccgcta cccacatcgt cagaagaggg gatgacgccc 1320
cctgcaggcc tctcgcagga gctaccactg cagccgcagc cgcagcccca gcagcgggga 1380
agacttctac caggagtggc ctggggtggg gctgccaagg aactggtggg caaccgcagc 1440
gcattaaggt tgagccggcg gggaccaggt ccccatcagg gcccctctgc tgcggctccg 1500
ggctctgccc cacagtcctt ggacctgcac gagaagccgg ggagaggacg tcacacccga 1560
gccaatctct cccagacgga gcccaccccg acgtctgagc ccgcctctgg gacaccatct 1620
gccagagaca gctggcagcg cgcagcaaag cagcgcctag cgtccgagca gcaagagagc 1680
gcagtccagt ccgttagtgg ggttggtttg ccacctctgg tgtctgaccc ctgtgacttc 1740
aacaaattca ttctgtgcaa cctgacagta gaggcggtga gcgccaacag cgcctcggtg 1800
cgctgggcgg ttcgcgaaca ccgcagtccc cggccgcagg gcggcgcacg cttccgcctg 1860
cttttcgacc gctttggcca gcagcccaag ttccagcgct tcgtctacct gccggagcgc 1920
agcgactcgg ccacgctgca cgagctgcgc ggagacaccc cctacctagt atgcgtggag 1980
ggtgtgctcg ggggtcgcgt ttgccccgtg gccccccgag accactgcgc agggttagta 2040
accctgccag aggcaggagg tcgaggtggc gtcgactacc agctcctgac cttggtcttg 2100
ctggctgtca acgcgcttct ggtgctcctg gcactggcag cctggggatc gcgatggctg 2160
cggaggaagc tgcgtgccag gcggaaggga ggggccccgg tccacgttcg ccacatgtac 2220
tccacccgac ggccactgcg ctccatgggc actggtgtgt ccgcggactt ctcaggcttc 2280
cagtcgcacc gtccccgcac caccgtgtgc gcgctcagcg aggccgacct cattgagttc 2340
ccctgcgacc gcttcatgga cagcaccggc ggtggtacca gtggcagctt gaggcgggag 2400
gatcacctct tgcaaagatt cgctgactag                                  2430

<210> 4
<211> 809
<212> PRT
<213> Mus musculus

<400> 4
Met Glu Gly Val Gly Ala Val Arg Phe Trp Leu Val Val Cys Gly Cys
 1               5                  10                  15      
Leu Ala Phe Pro Pro Arg Ala Glu Ser Val Cys Pro Glu Arg Cys Asp
            20                  25                  30          
Cys Gln His Pro Gln His Leu Leu Cys Thr Asn Arg Gly Leu Arg Ala
        35                  40                  45              
Val Pro Lys Thr Ser Ser Leu Pro Ser Pro Gln Asp Val Leu Thr Tyr
    50                  55                  60                  
Ser Leu Gly Gly Asn Phe Ile Thr Asn Ile Thr Ala Phe Asp Phe His
65                  70                  75                  80  
Arg Leu Gly Gln Leu Arg Arg Leu Asp Leu Gln Tyr Asn Gln Ile Arg
                85                  90                  95      
Ser Leu His Pro Lys Thr Phe Glu Lys Leu Ser Arg Leu Glu Glu Leu
            100                 105                 110         
Tyr Leu Gly Asn Asn Leu Leu Gln Ala Leu Val Pro Gly Thr Leu Ala
        115                 120                 125             
Pro Leu Arg Lys Leu Arg Ile Leu Tyr Ala Asn Gly Asn Glu Ile Gly
    130                 135                 140                 
Arg Leu Ser Arg Gly Ser Phe Glu Gly Leu Glu Ser Leu Val Lys Leu
145                 150                 155                 160 
Arg Leu Asp Gly Asn Val Leu Gly Ala Leu Pro Asp Ala Val Phe Ala
                165                 170                 175     
Pro Leu Gly Asn Leu Leu Tyr Leu His Leu Glu Ser Asn Arg Ile Arg
            180                 185                 190         
Phe Leu Gly Lys Asn Ala Phe Ser Gln Leu Gly Lys Leu Arg Phe Leu
        195                 200                 205             
Asn Leu Ser Ala Asn Glu Leu Gln Pro Ser Leu Arg His Ala Ala Thr
    210                 215                 220                 
Phe Val Pro Leu Arg Ser Leu Ser Thr Leu Ile Leu Ser Ala Asn Ser
225                 230                 235                 240 
Leu Gln His Leu Gly Pro Arg Val Phe Gln His Leu Pro Arg Leu Gly
                245                 250                 255     
Leu Leu Ser Leu Ser Gly Asn Gln Leu Thr His Leu Ala Pro Glu Ala
            260                 265                 270         
Phe Trp Gly Leu Glu Ala Leu Arg Glu Leu Arg Leu Glu Gly Asn Arg
        275                 280                 285             
Leu Asn Gln Leu Pro Leu Thr Leu Leu Glu Pro Leu His Ser Leu Glu
    290                 295                 300                 
Ala Leu Asp Leu Ser Gly Asn Glu Leu Ser Ala Leu His Pro Ala Thr
305                 310                 315                 320 
Phe Gly His Gln Gly Arg Leu Arg Glu Leu Ser Leu Arg Asp Asn Ala
                325                 330                 335     
Leu Ser Ala Leu Ser Gly Asp Ile Phe Ala Ala Ser Pro Ala Leu Tyr
            340                 345                 350         
Arg Leu Asp Leu Asp Gly Asn Gly Trp Thr Cys Asp Cys Arg Leu Arg
        355                 360                 365             
Gly Leu Lys Arg Trp Met Gly Asn Trp His Ser Gln Gly Arg Leu Leu
    370                 375                 380                 
Thr Val Phe Val Gln Cys Arg His Pro Pro Ala Leu Arg Gly Lys Tyr
385                 390                 395                 400 
Leu Asp Tyr Leu Asp Asp Gln Leu Leu Gln Asn Gly Ser Cys Val Asp
                405                 410                 415     
Pro Ser Pro Ser Pro Thr Ala Gly Ser Arg Gln Trp Pro Leu Pro Thr
            420                 425                 430         
Ser Ser Glu Glu Gly Met Thr Pro Pro Ala Gly Leu Ser Gln Glu Leu
        435                 440                 445             
Pro Leu Gln Pro Gln Pro Gln Pro Gln Gln Arg Gly Arg Leu Leu Pro
    450                 455                 460                 
Gly Val Ala Trp Gly Gly Ala Ala Lys Glu Leu Val Gly Asn Arg Ser
465                 470                 475                 480 
Ala Leu Arg Leu Ser Arg Arg Gly Pro Gly Pro His Gln Gly Pro Ser
                485                 490                 495     
Ala Ala Ala Pro Gly Ser Ala Pro Gln Ser Leu Asp Leu His Glu Lys
            500                 505                 510         
Pro Gly Arg Gly Arg His Thr Arg Ala Asn Leu Ser Gln Thr Glu Pro
        515                 520                 525             
Thr Pro Thr Ser Glu Pro Ala Ser Gly Thr Pro Ser Ala Arg Asp Ser
    530                 535                 540                 
Trp Gln Arg Ala Ala Lys Gln Arg Leu Ala Ser Glu Gln Gln Glu Ser
545                 550                 555                 560 
Ala Val Gln Ser Val Ser Gly Val Gly Leu Pro Pro Leu Val Ser Asp
                565                 570                 575     
Pro Cys Asp Phe Asn Lys Phe Ile Leu Cys Asn Leu Thr Val Glu Ala
            580                 585                 590         
Val Ser Ala Asn Ser Ala Ser Val Arg Trp Ala Val Arg Glu His Arg
        595                 600                 605             
Ser Pro Arg Pro Gln Gly Gly Ala Arg Phe Arg Leu Leu Phe Asp Arg
    610                 615                 620                 
Phe Gly Gln Gln Pro Lys Phe Gln Arg Phe Val Tyr Leu Pro Glu Arg
625                 630                 635                 640 
Ser Asp Ser Ala Thr Leu His Glu Leu Arg Gly Asp Thr Pro Tyr Leu
                645                 650                 655     
Val Cys Val Glu Gly Val Leu Gly Gly Arg Val Cys Pro Val Ala Pro
            660                 665                 670         
Arg Asp His Cys Ala Gly Leu Val Thr Leu Pro Glu Ala Gly Gly Arg
        675                 680                 685             
Gly Gly Val Asp Tyr Gln Leu Leu Thr Leu Val Leu Leu Ala Val Asn
    690                 695                 700                 
Ala Leu Leu Val Leu Leu Ala Leu Ala Ala Trp Gly Ser Arg Trp Leu
705                 710                 715                 720 
Arg Arg Lys Leu Arg Ala Arg Arg Lys Gly Gly Ala Pro Val His Val
                725                 730                 735     
Arg His Met Tyr Ser Thr Arg Arg Pro Leu Arg Ser Met Gly Thr Gly
            740                 745                 750         
Val Ser Ala Asp Phe Ser Gly Phe Gln Ser His Arg Pro Arg Thr Thr
        755                 760                 765             
Val Cys Ala Leu Ser Glu Ala Asp Leu Ile Glu Phe Pro Cys Asp Arg
    770                 775                 780                 
Phe Met Asp Ser Thr Gly Gly Gly Thr Ser Gly Ser Leu Arg Arg Glu
785                 790                 795                 800 
Asp His Leu Leu Gln Arg Phe Ala Asp
                805                 


<210> 5
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 5
agcaggcagt aggcag                                                 16

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 6
ggaacttggg ctgct                                                  15

<210> 7
<211> 1422
<212> DNA
<213> Homo sapiens

<400> 7
atgaagaggg cgtccgctgg agggagccgg ctgctggcat gggtgctgtg gctgcaggcc 60
tggcaggtgg cagccccatg cccaggtgcc tgcgtatgct acaatgagcc caaggtgacg 120
acaagctgcc cccagcaggg cctgcaggct gtgcccgtgg gcatccctgc tgccagccag 180
cgcatcttcc tgcacggcaa ccgcatctcg catgtgccag ctgccagctt ccgtgcctgc 240
cgcaacctca ccatcctgtg gctgcactcg aatgtgctgg cccgaattga tgcggctgcc 300
ttcactggcc tggccctcct ggagcagctg gacctcagcg ataatgcaca gctccggtct 360
gtggaccctg ccacattcca cggcctgggc cgcctacaca cgctgcacct ggaccgctgc 420
ggcctgcagg agctgggccc ggggctgttc cgcggcctgg ctgccctgca gtacctctac 480
ctgcaggaca acgcgctgca ggcactgcct gatgacacct tccgcgacct gggcaacctc 540
acacacctct tcctgcacgg caaccgcatc tccagcgtgc ccgagcgcgc cttccgtggg 600
ctgcacagcc tcgaccgtct cctactgcac cagaaccgcg tggcccatgt gcacccgcat 660
gccttccgtg accttggccg cctcatgaca ctctatctgt ttgccaacaa tctatcagcg 720
ctgcccactg aggccctggc ccccctgcgt gccctgcagt acctgaggct caacgacaac 780
ccctgggtgt gtgactgccg ggcacgccca ctctgggcct ggctgcagaa gttccgcggc 840
tcctcctccg aggtgccctg cagcctcccg caacgcctgg ctggccgtga cctcaaacgc 900
ctagctgcca atgacctgca gggctgcgct gtggccaccg gcccttacca tcccatctgg 960
accggcaggg ccaccgatga ggagccgctg gggcttccca agtgctgcca gccagatgcc 1020
gctgacaagg cctcagtact ggagcctgga agaccagctt cggcaggcaa tgcgctgaag 1080
ggacgcgtgc cgcccggtga cagcccgccg ggcaacggct ctggcccacg gcacatcaat 1140
gactcaccct ttgggactct gcctggctct gctgagcccc cgctcactgc agtgcggccc 1200
gagggctccg agccaccagg gttccccacc tcgggccctc gccggaggcc aggctgttca 1260
cgcaagaacc gcacccgcag ccactgccgt ctgggccagg caggcagcgg gggtggcggg 1320
actggtgact cagaaggctc aggtgcccta cccagcctca cctgcagcct cacccccctg 1380
ggcctggcgc tggtgctgtg gacagtgctt gggccctgct ga                    1422

<210> 8
<211> 473
<212> PRT
<213> Homo sapiens

<400> 8
Met Lys Arg Ala Ser Ala Gly Gly Ser Arg Leu Leu Ala Trp Val Leu
 1               5                  10                  15      
Trp Leu Gln Ala Trp Gln Val Ala Ala Pro Cys Pro Gly Ala Cys Val
            20                  25                  30          
Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu
        35                  40                  45              
Gln Ala Val Pro Val Gly Ile Pro Ala Ala Ser Gln Arg Ile Phe Leu
    50                  55                  60                  
His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Arg Ala Cys
65                  70                  75                  80  
Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Val Leu Ala Arg Ile
                85                  90                  95      
Asp Ala Ala Ala Phe Thr Gly Leu Ala Leu Leu Glu Gln Leu Asp Leu
            100                 105                 110         
Ser Asp Asn Ala Gln Leu Arg Ser Val Asp Pro Ala Thr Phe His Gly
        115                 120                 125             
Leu Gly Arg Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu
    130                 135                 140                 
Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr
145                 150                 155                 160 
Leu Gln Asp Asn Ala Leu Gln Ala Leu Pro Asp Asp Thr Phe Arg Asp
                165                 170                 175     
Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Ser Ser
            180                 185                 190         
Val Pro Glu Arg Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu
        195                 200                 205             
Leu His Gln Asn Arg Val Ala His Val His Pro His Ala Phe Arg Asp
    210                 215                 220                 
Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Ala
225                 230                 235                 240 
Leu Pro Thr Glu Ala Leu Ala Pro Leu Arg Ala Leu Gln Tyr Leu Arg
                245                 250                 255     
Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp
            260                 265                 270         
Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Ser
        275                 280                 285             
Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Ala Asn
    290                 295                 300                 
Asp Leu Gln Gly Cys Ala Val Ala Thr Gly Pro Tyr His Pro Ile Trp
305                 310                 315                 320 
Thr Gly Arg Ala Thr Asp Glu Glu Pro Leu Gly Leu Pro Lys Cys Cys
                325                 330                 335     
Gln Pro Asp Ala Ala Asp Lys Ala Ser Val Leu Glu Pro Gly Arg Pro
            340                 345                 350         
Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg Val Pro Pro Gly Asp Ser
        355                 360                 365             
Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn Asp Ser Pro Phe
    370                 375                 380                 
Gly Thr Leu Pro Gly Ser Ala Glu Pro Pro Leu Thr Ala Val Arg Pro
385                 390                 395                 400 
Glu Gly Ser Glu Pro Pro Gly Phe Pro Thr Ser Gly Pro Arg Arg Arg
                405                 410                 415     
Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His Cys Arg Leu Gly
            420                 425                 430         
Gln Ala Gly Ser Gly Gly Gly Gly Thr Gly Asp Ser Glu Gly Ser Gly
        435                 440                 445             
Ala Leu Pro Ser Leu Thr Cys Ser Leu Thr Pro Leu Gly Leu Ala Leu
    450                 455                 460                 
Val Leu Trp Thr Val Leu Gly Pro Cys
465                 470             


<210> 9
<211> 1890
<212> DNA
<213> Mus musculus

<400> 9
ccgcagcccg cgagcccagc ccggcccggt agagcggagc gccggagcct cgtcccgcgg 60
ccgggccggg accgggccgg agcagcggcg cctggatgcg gacccggccg cgcgcagacg 120
ggcgcccgcc ccgaagccgc ttccagtgcc cgacgcgccc cgctcgaccc cgaagatgaa 180
gagggcgtcc tccggaggaa gcaggctgct ggcatgggtg ttatggctac aggcctggag 240
ggtagcaaca ccatgccctg gtgcttgtgt gtgctacaat gagcccaagg taacaacaag 300
ctgcccccag cagggtctgc aggctgtgcc cactggcatc ccagcctcta gccagcgaat 360
cttcctgcat ggcaaccgaa tctctcacgt gccagctgcg agcttccagt catgccgaaa 420
tctcactatc ctgtggctgc actctaatgc gctggctcgg atcgatgctg ctgccttcac 480
tggtctgacc ctcctggagc aactagatct tagtgataat gcacagcttc atgtcgtgga 540
ccctaccacg ttccacggcc tgggccacct gcacacactg cacctagacc gatgtggcct 600
gcgggagctg ggtcccggcc tattccgtgg actagcagct ctgcagtacc tctacctaca 660
agacaacaat ctgcaggcac tccctgacaa cacctttcga gacctgggca acctcacgca 720
tctctttctg catggcaacc gtatccccag tgtgcctgag cacgctttcc gtggcctgca 780
cagtcttgac cgcctcctct tgcaccagaa ccatgtggct cgtgtgcacc cacatgcctt 840
ccgggacctt ggccgcctca tgaccctcta cctgtttgcc aacaacctct ccatgctgcc 900
tgcagaggtc ctaatgcccc tgaggtctct gcagtacctg cgactcaatg acaacccctg 960
ggtgtgtgac tgccgggcac gtccactctg ggcctggctg cagaagttcc gaggttcctc 1020
atcagaggtg ccctgcaacc tgccccaacg cctggcagac cgtgatctta agcgcctcgc 1080
tgccagtgac ctagagggct gtgctgtggc ttcaggaccc ttccgtccca tccagaccag 1140
tcagctcact gatgaggagc tgctgagcct ccccaagtgc tgccagccag atgctgcaga 1200
caaagcctca gtactggaac ccgggaggcc agcttctgcc ggaaacgccc tcaagggacg 1260
tgtgcctccc ggtgacactc caccaggcaa tggctcaggc cctcggcaca tcaatgactc 1320
tccatttgga actttgccca gctctgcaga gcccccactg actgccctgc ggcctggggg 1380
ttccgagcca ccaggacttc ccaccactgg tccccgcagg aggccaggtt gttcccggaa 1440
gaatcgcacc cgcagccact gccgtctggg ccaggcggga agtggggcca gtggaacagg 1500
ggacgcagag ggttcagggg ctctgcctgc tctggcctgc agccttgctc ctctgggcct 1560
tgcactggta ctttggacag tgcttgggcc ctgctgacca gccaccagcc accaggtgtg 1620
tgtacatatg gggtctccct ccacgccgcc agccagagcc agggacaggc tctgaggggc 1680
aggccaggcc ctccctgaca gatgcctccc caccagccca cccccatctc caccccatca 1740
tgtttacagg gttccggggg tggcgtttgt tccagaacgc cacctcccac ccggatcgcg 1800
gtatatagag atatgaattt tattttactt gtgtaaaata tcggatgacg tggaataaag 1860
agctcttttc ttaaaaaaaa aaaaaaaaaa                                  1890

<210> 10
<211> 473
<212> PRT
<213> Mus musculus

<400> 10
Pro Lys Arg Ala Ser Ser Gly Gly Ser Arg Leu Leu Ala Trp Val Leu
 1               5                  10                  15      
Trp Leu Gln Ala Trp Arg Val Ala Thr Pro Cys Pro Gly Ala Cys Val
            20                  25                  30          
Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu
        35                  40                  45              
Gln Ala Val Pro Thr Gly Ile Pro Ala Ser Ser Gln Arg Ile Phe Leu
    50                  55                  60                  
His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Gln Ser Cys
65                  70                  75                  80  
Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Ala Leu Ala Arg Ile
                85                  90                  95      
Asp Ala Ala Ala Phe Thr Gly Leu Thr Leu Leu Glu Gln Leu Asp Leu
            100                 105                 110         
Ser Asp Asn Ala Gln Leu His Val Val Asp Pro Thr Thr Phe His Gly
        115                 120                 125             
Leu Gly His Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Arg Glu
    130                 135                 140                 
Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr
145                 150                 155                 160 
Leu Gln Asp Asn Asn Leu Gln Ala Leu Pro Asp Asn Thr Phe Arg Asp
                165                 170                 175     
Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Pro Ser
            180                 185                 190         
Val Pro Glu His Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu
        195                 200                 205             
Leu His Gln Asn His Val Ala Arg Val His Pro His Ala Phe Arg Asp
    210                 215                 220                 
Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Met
225                 230                 235                 240 
Leu Pro Ala Glu Val Leu Met Pro Leu Arg Ser Leu Gln Tyr Leu Arg
                245                 250                 255     
Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp
            260                 265                 270         
Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Asn
        275                 280                 285             
Leu Pro Gln Arg Leu Ala Asp Arg Asp Leu Lys Arg Leu Ala Ala Ser
    290                 295                 300                 
Asp Leu Glu Gly Cys Ala Val Ala Ser Gly Pro Phe Arg Pro Ile Gln
305                 310                 315                 320 
Thr Ser Gln Leu Thr Asp Glu Glu Leu Leu Ser Leu Pro Lys Cys Cys
                325                 330                 335     
Gln Pro Asp Ala Ala Asp Lys Ala Ser Val Leu Glu Pro Gly Arg Pro
            340                 345                 350         
Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg Val Pro Pro Gly Asp Thr
        355                 360                 365             
Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn Asp Ser Pro Phe
    370                 375                 380                 
Gly Thr Leu Pro Ser Ser Ala Glu Pro Pro Leu Thr Ala Leu Arg Pro
385                 390                 395                 400 
Gly Gly Ser Glu Pro Pro Gly Leu Pro Thr Thr Gly Pro Arg Arg Arg
                405                 410                 415     
Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His Cys Arg Leu Gly
            420                 425                 430         
Gln Ala Gly Ser Gly Ala Ser Gly Thr Gly Asp Ala Glu Gly Ser Gly
        435                 440                 445             
Ala Leu Pro Ala Leu Ala Cys Ser Leu Ala Pro Leu Gly Leu Ala Leu
    450                 455                 460                 
Val Leu Trp Thr Val Leu Gly Pro Cys
465                 470             


<210> 11
<211> 3386
<212> DNA
<213> Homo sapiens

<400> 11
gccgcggcca gctccggcgg gcaggggggg cgctggagcg cagcgcagcg cagccccatc 60
agtccgcaaa gcggaccgag ctggaagtcg agcgctgccg cgggaggcgg gcgatggggg 120
caggtgccac cggccgcgcc atggacgggc cgcgcctgct gctgttgctg cttctggggg 180
tgtcccttgg aggtgccaag gaggcatgcc ccacaggcct gtacacacac agcggtgagt 240
gctgcaaagc ctgcaacctg ggcgagggtg tggcccagcc ttgtggagcc aaccagaccg 300
tgtgtgagcc ctgcctggac agcgtgacgt tctccgacgt ggtgagcgcg accgagccgt 360
gcaagccgtg caccgagtgc gtggggctcc agagcatgtc ggcgccgtgc gtggaggccg 420
acgacgccgt gtgccgctgc gcctacggct actaccagga tgagacgact gggcgctgcg 480
aggcgtgccg cgtgtgcgag gcgggctcgg gcctcgtgtt ctcctgccag gacaagcaga 540
acaccgtgtg cgaggagtgc cccgacggca cgtattccga cgaggccaac cacgtggacc 600
cgtgcctgcc ctgcaccgtg tgcgaggaca ccgagcgcca gctccgcgag tgcacacgct 660
gggccgacgc cgagtgcgag gagatccctg gccgttggat tacacggtcc acacccccag 720
agggctcgga cagcacagcc cccagcaccc aggagcctga ggcacctcca gaacaagacc 780
tcatagccag cacggtggca ggtgtggtga ccacagtgat gggcagctcc cagcccgtgg 840
tgacccgagg caccaccgac aacctcatcc ctgtctattg ctccatcctg gctgctgtgg 900
ttgtgggcct tgtggcctac atagccttca agaggtggaa cagctgcaag cagaacaagc 960
aaggagccaa cagccggcca gtgaaccaga cgcccccacc agagggagaa aaactccaca 1020
gcgacagtgg catctccgtg gacagccaga gcctgcatga ccagcagccc cacacgcaga 1080
cagcctcggg ccaggccctc aagggtgacg gaggcctcta cagcagcctg cccccagcca 1140
agcgggagga ggtggagaag cttctcaacg gctctgcggg ggacacctgg cggcacctgg 1200
cgggcgagct gggctaccag cccgagcaca tagactcctt tacccatgag gcctgccccg 1260
ttcgcgccct gcttgcaagc tgggccaccc aggacagcgc cacactggac gccctcctgg 1320
ccgccctgcg ccgcatccag cgagccgacc tcgtggagag tctgtgcagt gagtccactg 1380
ccacatcccc ggtgtgagcc caaccgggga gcccccgccc cgccccacat tccgacaacc 1440
gatgctccag ccaacccctg tggagcccgc acccccaccc tttggggggg gcccgcctgg 1500
cagaactgag ctcctctggg caggacctca gagtccaggc cccaaaacca cagccctgtc 1560
agtgcagccc gtgtggcccc ttcacttctg accacacttc ctgtccagag agagaagtgc 1620
ccctgctgcc tccccaaccc tgcccctgcc ccgtcaccat ctcaggccac ctgccccctt 1680
ctcccacact gctaggtggg ccagcccctc ccaccacagc aggtgtcata tatggggggc 1740
caacaccagg gatggtacta gggggaagtg acaaggcccc agagactcag agggaggaat 1800
cgaggaacca gagccatgga ctctacactg tgaacttggg gaacaagggt ggcatcccag 1860
tggcctcaac cctccctcag cccctcttgc cccccacccc agcctaagat gaagaggatc 1920
ggaggcttgt cagagctggg aggggttttc gaagctcagc ccacccccct cattttggat 1980
ataggtcagt gaggcccagg gagaggccat gattcgccca aagccagaca gcaacgggga 2040
ggccaagtgc aggctggcac cgccttctct aaatgagggg cctcaggttt gcctgagggc 2100
gaggggaggg tggcaggtga ccttctggga aatggcttga agccaagtca gctttgcctt 2160
ccacgctgtc tccagacccc caccccttcc ccactgcctg cccacccgtg gagatgggat 2220
gcttgcctag ggcctggtcc atgatggagt caggtttggg gttcgtggaa agggtgctgc 2280
ttccctctgc ctgtccctct caggcatgcc tgtgtgacat cagtggcatg gctccagtct 2340
gctgccctcc atcccgacat ggacccggag ctaacactgg cccctagaat cagcctaggg 2400
gtcagggacc aaggacccct caccttgcaa cacacagaca cacgcacaca cacacacagg 2460
aggagaaatc tcacttttct ccatgagttt tttctcttgg gctgagactg gatactgccc 2520
ggggcagctg ccagagaagc atcggaggga attgaggtct gctcggccgt cttcactcgc 2580
ccccgggttt ggcgggccaa ggactgccga ccgaggctgg agctggcgtc tgtcttcaag 2640
ggcttacacg tggaggaatg ctcccccatc ctccccttcc ctgcaaacat ggggttggct 2700
gggcccagaa ggttgcgatg aagaaaagcg ggccagtgtg ggaatgcggc aagaaggaat 2760
tgacttcgac tgtgacctgt ggggatttct cccagctcta gacaaccctg caaaggactg 2820
ttttttcctg agcttggcca gaagggggcc atgaggcctc agtggacttt ccaccccctc 2880
cctggcctgt tctgttttgc ctgaagttgg agtgagtgtg gctcccctct atttagcatg 2940
acaagcccca ggcaggctgt gcgctgacaa ccaccgctcc ccagcccagg gttcccccag 3000
ccctgtggaa gggactagga gcactgtagt aaatggcaat tctttgacct caacctgtga 3060
tgaggggagg aaactcacct gctggcccct cacctgggca cctggggagt gggacagagt 3120
ctgggtgtat ttattttcct ccccagcagg tggggagggg gtttggtggc ttgcaagtat 3180
gttttagcat gtgtttggtt ctggggcccc tttttactcc ccttgagctg agatggaacc 3240
cttttggccc ccagctgggg gccatgagct ccagaccccc agcaaccctc ctatcacctc 3300
ccctccttgc ctcctgtgta atcatttctt gggccctcct gaaacttaca cacaaaacgt 3360
taagtgatga acattaaata gcaaag                                      3386

<210> 12
<211> 427
<212> PRT
<213> Homo sapiens

<400> 12
Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys
            20                  25                  30          
Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn
        35                  40                  45              
Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys
    50                  55                  60                  
Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr
65                  70                  75                  80  
Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser
                85                  90                  95      
Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly
            100                 105                 110         
Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys
        115                 120                 125             
Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr
    130                 135                 140                 
Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His
145                 150                 155                 160 
Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln
                165                 170                 175     
Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro
            180                 185                 190         
Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr
        195                 200                 205             
Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile
    210                 215                 220                 
Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln
225                 230                 235                 240 
Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys
                245                 250                 255     
Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe
            260                 265                 270         
Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn Ser Arg
        275                 280                 285             
Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His Ser Asp
    290                 295                 300                 
Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln Gln Pro His
305                 310                 315                 320 
Thr Gln Thr Ala Ser Gly Gln Ala Leu Lys Gly Asp Gly Gly Leu Tyr
                325                 330                 335     
Ser Ser Leu Pro Pro Ala Lys Arg Glu Glu Val Glu Lys Leu Leu Asn
            340                 345                 350         
Gly Ser Ala Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu Gly Tyr
        355                 360                 365             
Gln Pro Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro Val Arg
    370                 375                 380                 
Ala Leu Leu Ala Ser Trp Ala Thr Gln Asp Ser Ala Thr Leu Asp Ala
385                 390                 395                 400 
Leu Leu Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Leu Val Glu Ser
                405                 410                 415     
Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val
            420                 425         


<210> 13
<211> 3409
<212> DNA
<213> Mus musculus

<400> 13
agagcgagtg gagcctccgc cagctccggc gggcagcggg cgctggagcg cagcgcagcg 60
cagctcagct cagcgcgcag caccatcggt ccgcagagcg gactgagcta gaagctgagc 120
gctgtcgccg gaggcgagca atgaggaggg caggtgctgc ctgcagcgcc atggaccggc 180
tgcgcctgct gctgctgctg ctgctgcttc taggggtgtc ctttggaggt gccaaggaga 240
catgttccac aggcatgtac acccacagtg gagagtgctg caaagcctgc aacctgggcg 300
aaggtgtggc ccagccttgc ggagccaacc agaccgtgtg tgaaccctgc ctggacagtg 360
ttacgttctc tgacgtggtg agcgccaccg agccgtgcaa gccgtgcacc gagtgcctgg 420
gcctgcagag tatgtccgct ccctgtgtgg aggcagacga tgccgtgtgc cgatgctcct 480
atggctacta ccaggacgag gagactggcc gctgcgaggc ttgcagcgtg tgcggggtgg 540
gctcaggact cgtgttctcc tgccaggaca aacagaacac agtgtgtgaa gagtgcccag 600
agggcacata ctcagatgaa gccaaccacg tggacccgtg cctaccctgc acggtgtgcg 660
aggacactga gcgccagtta cgcgagtgca cgccctgggc tgacgccgaa tgcgaggaga 720
tccctggccg atggatcaca aggtctacgc ccccggaggg ctctgacgtc acaacaccca 780
gcacccagga gccggaggca cctccagagc gagacctcat agccagcaca gtggccgata 840
cggtgaccac tgtgatgggc agctcccagc ctgtagtgac ccgaggcacc gctgacaacc 900
tcattcctgt ctattgctcc atcttggctg ctgtggttgt gggccttgtg gcctatattg 960
ctttcaagag atggaacagc tgcaagcaaa ataaacaagg agccaacagc cggccggtga 1020
accagacacc cccaccagag ggagagaaac tgcacagcga cagcggcatc tctgtggaca 1080
gccagagcct gcacgaccag cagacccaca cacagactgc ctcaggccaa gccctcaagg 1140
gtgatggcaa cctctacagt agcctgcccc tgaccaagcg tgaggaggtc gagaagctgc 1200
tcaatggtga cacctggcga catctggcag gcgagctggg ctaccagccg gagcatatag 1260
actcctttac ccacgaggcc tgcccagtcc gagccctgct ggccagctgg ggtgcccagg 1320
acagcgcgac gctcgatgcc cttttagccg ccctgcgacg catccagaga gctgacattg 1380
tggagagcct gtgcagcgag tccactgcca cgtcccctgt gtgagctcac cgactgggag 1440
cccctgtcct gtcccacatt ccgaccgctg atgttctagc ccccacagag ccgcccccct 1500
ctcccttggg gtggcccaac agtcagaacc gagcatctct gtgtagggcc tctgtgtccc 1560
gctccccaaa ccacagccct gttgctgctc ctgaggggac ctttgcttct gaccacactc 1620
tctctccggc gagagatagg accaccccaa gcctgtcttg ccccgtgacc atctcaggcc 1680
tttcctttct ttctacacat taactgtgtc agatctaggg gtctgacact agagaaggta 1740
acaggggcac ccctaagact cagggggtac taatgaacca gagccatgga ctccacactg 1800
tgaactggag aacagggggg gcattgtggt aggccagacc ttcctcaacc cctcccttct 1860
cccatctggc caaagatgaa gaggattaca ggcctatctg agctgaaagc aggtttggag 1920
cccagtccac actccttctc ttacacatag gatggtaaag cccagagagg cagggactaa 1980
cctaggccac ccaacaacag ggagatcaat tgtaggctga cacactcctt tctgaatgag 2040
ggcgtcaagt gcttgttggc agggatggag tgactttcag ggaaacatct ggaaacgacg 2100
tctgccccgc cctcaaccac ttccaggccc ctacccaacc cttgtgcaga tgaactgtct 2160
gttcaaaacc tggtccattg gcctgttctg atggagtcgg gctaatgtcc tggggagtgg 2220
ggtgctgcct tcctctgtct gtcaggctta gccacagggc atttgtggag ggatgaatct 2280
gttagcaccc tcattcgtgt cataagcctg aagccaacag tggcccttgg agtcaaccct 2340
aggggtcagg gaccaaggac ccaccccata atccaacacc acacacacac acacacacac 2400
acacacacac agagagagag agagagagag agagagagag agagagagag agagatcatg 2460
cttttccccc catggctctt tttgggctga gaccagatcc tgctggaagt cgctggctgc 2520
cagagaaaga tggaagggga ccgagatgag cttcgtgggg ctgtcttcct cacctcccgg 2580
ctctggcagg ccaagaactg ctgcatctga gctggcgtgc gtgcgtccgt ccctgtccgt 2640
cggtctccaa tggcctgtgt gtggaggaat gctcacaccg ctccctctcc tccccttctt 2700
gaagcccaac tttggctgca cccagaaaac agtgaagaaa agcaggctgc tgtgagaaca 2760
caagaaaatg cagatgctgg cccgcagtct gaggcaactt tctcctcagt ttcatggccc 2820
ctgcaaagga ccaatttcct gggcatggcc aggaagggac ccgagtgctc attggccggc 2880
gctttcacct ggctccttgg cctgttctgt tttgcttgct gttggaatga gtgggctccc 2940
cctctattta gcatgaagga gccccaggca gggtatgcac agactgactg ccatccctcc 3000
ccacccaggg tccacccagc cctgtaagga gacaaggagc cttgtgctcg gtggtatttt 3060
tatggacctc gatctgcaat tagtagaagg accccaccgg ctggccctcc ccggacacct 3120
gggaagtggg acattctttg tgtatttatt ttcctccccc agaagctggg ggtgggtggg 3180
tgggggagga gctgcaggac cagtttagca tgtgtttggt tctgggggtc tctccagcct 3240
tattttgggt caagatggaa cctctggccc tccagctggc gactatgaga tccagacctc 3300
ttcatgttcc ctgacacttc ccctttgcat cctgtgtaat catttcttgg gccctcccaa 3360
aacctacaca taaaacatac gtgatgacca ttaaatagca aaaaaaaaa             3409

<210> 14
<211> 427
<212> PRT
<213> Mus musculus

<400> 14
Met Arg Arg Ala Gly Ala Ala Cys Ser Ala Met Asp Arg Leu Arg Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Leu Leu Gly Val Ser Phe Gly Gly Ala Lys
            20                  25                  30          
Glu Thr Cys Ser Thr Gly Met Tyr Thr His Ser Gly Glu Cys Cys Lys
        35                  40                  45              
Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln
    50                  55                  60                  
Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val
65                  70                  75                  80  
Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Leu Gly Leu Gln
                85                  90                  95      
Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys
            100                 105                 110         
Ser Tyr Gly Tyr Tyr Gln Asp Glu Glu Thr Gly Arg Cys Glu Ala Cys
        115                 120                 125             
Ser Val Cys Gly Val Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys
    130                 135                 140                 
Gln Asn Thr Val Cys Glu Glu Cys Pro Glu Gly Thr Tyr Ser Asp Glu
145                 150                 155                 160 
Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr
                165                 170                 175     
Glu Arg Gln Leu Arg Glu Cys Thr Pro Trp Ala Asp Ala Glu Cys Glu
            180                 185                 190         
Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser
        195                 200                 205             
Asp Val Thr Thr Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Arg
    210                 215                 220                 
Asp Leu Ile Ala Ser Thr Val Ala Asp Thr Val Thr Thr Val Met Gly
225                 230                 235                 240 
Ser Ser Gln Pro Val Val Thr Arg Gly Thr Ala Asp Asn Leu Ile Pro
                245                 250                 255     
Val Tyr Cys Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr
            260                 265                 270         
Ile Ala Phe Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala
        275                 280                 285             
Asn Ser Arg Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu
    290                 295                 300                 
His Ser Asp Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln
305                 310                 315                 320 
Gln Thr His Thr Gln Thr Ala Ser Gly Gln Ala Leu Lys Gly Asp Gly
                325                 330                 335     
Asn Leu Tyr Ser Ser Leu Pro Leu Thr Lys Arg Glu Glu Val Glu Lys
            340                 345                 350         
Leu Leu Asn Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu Gly Tyr
        355                 360                 365             
Gln Pro Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro Val Arg
    370                 375                 380                 
Ala Leu Leu Ala Ser Trp Gly Ala Gln Asp Ser Ala Thr Leu Asp Ala
385                 390                 395                 400 
Leu Leu Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Ile Val Glu Ser
                405                 410                 415     
Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val
            420                 425         


<210> 15
<211> 1422
<212> DNA
<213> Rattus norvegicus

<400> 15
atgaagaggg cgtcctccgg aggaagccgg ctgccgacat gggtgttatg gctacaggcc 60
tggagggtag caacgccctg ccctggtgcc tgtgtgtgct acaatgagcc caaggtcaca 120
acaagccgcc cccagcaggg cctgcaggct gtacccgctg gcatcccagc ctccagccag 180
agaatcttcc tgcacggcaa ccgaatctct tacgtgccag ccgccagctt ccagtcatgc 240
cggaatctca ccatcctgtg gctgcactca aatgcgctgg ccgggattga tgccgcggcc 300
ttcactggtc tgaccctcct ggagcaacta gatcttagtg acaatgcaca gctccgtgtc 360
gtggacccca ccacgttccg tggcctgggc cacctgcaca cgctgcacct agaccgatgc 420
ggcctgcagg agctggggcc tggcctattc cgtgggctgg cagctctgca gtacctctac 480
ctacaagaca acaacctgca ggcacttccc gacaacacct tccgagacct gggcaacctc 540
acgcatctct ttctgcatgg caaccgtatc cccagtgttc ctgagcacgc tttccgtggc 600
ttgcacagtc ttgaccgtct cctcttgcac cagaaccatg tggctcgtgt gcacccacat 660
gccttccggg accttggccg actcatgacc ctctacctgt ttgccaacaa cctctccatg 720
ctccccgcag aggtcctagt gcccctgagg tctctgcagt acctgcgact caatgacaac 780
ccctgggtgt gtgactgcag ggcacgtccg ctctgggcct ggctgcagaa gttccgaggt 840
tcctcatccg gggtgcccag caacctaccc caacgcctgg caggccgtga tctgaagcgc 900
ctggctacca gtgacttaga gggttgtgct gtggcttcgg ggcccttccg tcccttccag 960
accaatcagc tcactgatga ggagctgctg ggcctcccca agtgctgcca gccggatgct 1020
gcagacaagg cctcagtact ggaacccggg aggccggcgt ctgttggaaa tgcactcaag 1080
ggacgtgtgc ctcccggtga cactccacca ggcaatggct caggcccacg gcacatcaat 1140
gactctccat ttgggacttt gcccggctct gcagagcccc cactgactgc cctgcggcct 1200
gggggttccg agcccccggg actgcccacc acgggccccc gcaggaggcc aggttgttcc 1260
agaaagaacc gcacccgtag ccactgccgt ctgggccagg caggaagtgg gagcagtgga 1320
actggggatg cagaaggttc gggggccctg cctgccctgg cctgcagcct tgctcctctg 1380
ggccttgcac tggtactttg gacagtgctt gggccctgct ga                    1422

<210> 16
<211> 473
<212> PRT
<213> Rattus norvegicus

<400> 16
Met Lys Arg Ala Ser Ser Gly Gly Ser Arg Leu Pro Thr Trp Val Leu
 1               5                  10                  15      
Trp Leu Gln Ala Trp Arg Val Ala Thr Pro Cys Pro Gly Ala Cys Val
            20                  25                  30          
Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Arg Pro Gln Gln Gly Leu
        35                  40                  45              
Gln Ala Val Pro Ala Gly Ile Pro Ala Ser Ser Gln Arg Ile Phe Leu
    50                  55                  60                  
His Gly Asn Arg Ile Ser Tyr Val Pro Ala Ala Ser Phe Gln Ser Cys
65                  70                  75                  80  
Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Ala Leu Ala Gly Ile
                85                  90                  95      
Asp Ala Ala Ala Phe Thr Gly Leu Thr Leu Leu Glu Gln Leu Asp Leu
            100                 105                 110         
Ser Asp Asn Ala Gln Leu Arg Val Val Asp Pro Thr Thr Phe Arg Gly
        115                 120                 125             
Leu Gly His Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu
    130                 135                 140                 
Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr
145                 150                 155                 160 
Leu Gln Asp Asn Asn Leu Gln Ala Leu Pro Asp Asn Thr Phe Arg Asp
                165                 170                 175     
Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Pro Ser
            180                 185                 190         
Val Pro Glu His Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu
        195                 200                 205             
Leu His Gln Asn His Val Ala Arg Val His Pro His Ala Phe Arg Asp
    210                 215                 220                 
Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Met
225                 230                 235                 240 
Leu Pro Ala Glu Val Leu Val Pro Leu Arg Ser Leu Gln Tyr Leu Arg
                245                 250                 255     
Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp
            260                 265                 270         
Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Gly Val Pro Ser Asn
        275                 280                 285             
Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Thr Ser
    290                 295                 300                 
Asp Leu Glu Gly Cys Ala Val Ala Ser Gly Pro Phe Arg Pro Phe Gln
305                 310                 315                 320 
Thr Asn Gln Leu Thr Asp Glu Glu Leu Leu Gly Leu Pro Lys Cys Cys
                325                 330                 335     
Gln Pro Asp Ala Ala Asp Lys Ala Ser Val Leu Glu Pro Gly Arg Pro
            340                 345                 350         
Ala Ser Val Gly Asn Ala Leu Lys Gly Arg Val Pro Pro Gly Asp Thr
        355                 360                 365             
Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn Asp Ser Pro Phe
    370                 375                 380                 
Gly Thr Leu Pro Gly Ser Ala Glu Pro Pro Leu Thr Ala Leu Arg Pro
385                 390                 395                 400 
Gly Gly Ser Glu Pro Pro Gly Leu Pro Thr Thr Gly Pro Arg Arg Arg
                405                 410                 415     
Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His Cys Arg Leu Gly
            420                 425                 430         
Gln Ala Gly Ser Gly Ser Ser Gly Thr Gly Asp Ala Glu Gly Ser Gly
        435                 440                 445             
Ala Leu Pro Ala Leu Ala Cys Ser Leu Ala Pro Leu Gly Leu Ala Leu
    450                 455                 460                 
Val Leu Trp Thr Val Leu Gly Pro Cys
465                 470             







