                         SEQUENCE LISTING

<110>  The University Court of The University of St Andrews and 
       The University of Guelph
       Naismith, James
       Whitfield, Christopher
       Dong, Changjiang
       Beis, Kostantinos
 
<120>  Membrane Protein Wza and Method of Selecting Inhibitory Agents

<130>  P44918.WO.01

<150>  GB0620304.6
<151>  2006-10-13

<160>  27    

<170>  PatentIn version 3.3

<210>  1
<211>  227
<212>  PRT
<213>  Escherichia coli

<400>  1

Pro Gly Leu Ile Asp Gln Leu Arg Pro Glu Pro Val Ile Ala Arg Ser 
1               5                   10                  15      


Asn Pro Gln Leu Asp Asn Leu Leu Lys Ser Tyr Glu Tyr Arg Ile Gly 
            20                  25                  30          


Val Gly Asp Val Leu Met Val Thr Val Trp Asp His Pro Glu Leu Thr 
        35                  40                  45              


Thr Pro Ala Gly Gln Tyr Arg Ser Ala Ser Asp Thr Gly Asn Trp Val 
    50                  55                  60                  


Asn Ser Asp Gly Thr Ile Phe Tyr Pro Tyr Ile Gly Lys Val Gln Val 
65                  70                  75                  80  


Ala Gly Lys Thr Val Ser Gln Val Arg Gln Asp Ile Thr Ser Arg Leu 
                85                  90                  95      


Thr Thr Tyr Ile Glu Ser Pro Gln Val Asp Val Ser Ile Ala Ala Phe 
            100                 105                 110         


Arg Ser Gln Lys Val Tyr Val Thr Gly Glu Val Ala Asn Ser Gly Lys 
        115                 120                 125             


Gln Ala Ile Thr Asn Ile Pro Leu Thr Val Met Asp Ala Ile Asn Ala 
    130                 135                 140                 


Ala Gly Gly Leu Ala Ala Asp Ala Asp Trp Arg Asn Val Val Leu Thr 
145                 150                 155                 160 


His Asn Gly Lys Asp Thr Lys Ile Ser Leu Tyr Ala Leu Met Gln Lys 
                165                 170                 175     


Gly Asp Leu Thr Gln Asn His Leu Leu Tyr His Gly Asp Ile Leu Phe 
            180                 185                 190         


Ile Pro Ser Asn Asp Asp Leu Lys Val Phe Val Met Gly Glu Val Gly 
        195                 200                 205             


Lys Gln Ser Thr Leu Lys Met Asp Arg Ser Gly Met Thr Leu Ala Glu 
    210                 215                 220                 


Ala Leu Gly 
225         


<210>  2
<211>  232
<212>  PRT
<213>  Haemophilus influenzae

<400>  2

Glu Ser Leu Val Gln Gln Ile Tyr Ala Ala Gln Gln Ser Gln Arg Phe 
1               5                   10                  15      


Ser Gly Phe Ala Asp Val Arg Gly Asn Gly Gly Tyr Ala Gly Ala Val 
            20                  25                  30          


Asn Val Gly Asp Val Leu Glu Ile Ser Ile Trp Glu Ala Pro Pro Ala 
        35                  40                  45              


Val Leu Phe Gly Thr Thr Phe Ser Ser Glu Gly Gln Gly Ser Gly His 
    50                  55                  60                  


Val Thr Gln Leu Pro Ser Gln Ile Val Asn Lys Asn Gly Thr Val Thr 
65                  70                  75                  80  


Val Pro Phe Val Gly Asn Ile Ser Val Ala Gly Lys Thr Pro Glu Ala 
                85                  90                  95      


Ile Gln Ala Gln Ile Val Ala Ser Leu Ser Arg Lys Ala Asn Gln Pro 
            100                 105                 110         


Gln Ala Val Val Lys Ile Ala Asn Asn Asn Ser Ser Asp Val Thr Val 
        115                 120                 125             


Ile Arg Gln Gly Ser Ala Val Arg Met Pro Leu Thr Ala Asn Asp Glu 
    130                 135                 140                 


Arg Val Leu Asp Ala Val Ala Ala Ile Gly Gly Ser Thr Gly Asn Ile 
145                 150                 155                 160 


Glu Asp Val Thr Val Gln Leu Thr Arg Gly Asn Gln Val Lys Thr Leu 
                165                 170                 175     


Ala Phe Glu Thr Leu Ile Ala Asp Pro Lys Gln Asn Ile Val Leu Arg 
            180                 185                 190         


Ala Gly Asp Val Val Ser Leu Leu Asn Thr Pro Tyr Lys Phe Thr Gly 
        195                 200                 205             


Leu Gly Ala Val Gly Asn Asn Gln Gln Leu Arg Phe Ser Ser Ser Gly 
    210                 215                 220                 


Ile Thr Leu Ala Glu Ala Ile Gly 
225                 230         


<210>  3
<211>  229
<212>  PRT
<213>  Neisseria meningitidis

<400>  3

His Thr Val Ala Gln Leu Leu Tyr Lys Ala Gln Ile Asn Gln Ser Phe 
1               5                   10                  15      


Thr Gln Phe Gly Asp Gly Tyr Ala Ser Ala Gly Thr Leu Asn Ile Gly 
            20                  25                  30          


Asp Val Leu Asp Ile Met Ile Trp Glu Ala Pro Pro Ala Val Leu Phe 
        35                  40                  45              


Gly Gly Gly Leu Ser Ser Met Gly Ser Gly Ser Ala His Gln Thr Lys 
    50                  55                  60                  


Leu Pro Glu Gln Leu Val Thr Ala Arg Gly Thr Val Ser Val Pro Phe 
65                  70                  75                  80  


Val Gly Asp Ile Ser Val Val Gly Lys Thr Pro Gly Gln Val Gln Glu 
                85                  90                  95      


Ile Ile Lys Gly Arg Leu Lys Lys Met Ala Asn Gln Pro Gln Val Met 
            100                 105                 110         


Val Arg Leu Val Gln Asn Asn Ala Ala Asn Val Ser Val Ile Arg Ala 
        115                 120                 125             


Gly Asn Ser Val Arg Met Pro Leu Thr Ala Ala Gly Glu Arg Val Leu 
    130                 135                 140                 


Asp Ala Val Ala Ala Val Gly Gly Ser Thr Ala Asn Val Gln Asp Thr 
145                 150                 155                 160 


Asn Val Gln Leu Thr Arg Gly Asn Val Val Arg Thr Val Ala Leu Glu 
                165                 170                 175     


Asp Leu Val Ala Asn Pro Arg Gln Asn Ile Leu Leu Arg Arg Gly Asp 
            180                 185                 190         


Val Val Thr Met Ile Thr Asn Pro Tyr Thr Phe Thr Ser Met Gly Ala 
        195                 200                 205             


Val Gly Arg Thr Gln Glu Ile Gly Phe Ser Ala Arg Gly Leu Ser Leu 
    210                 215                 220                 


Ser Glu Ala Ile Gly 
225                 


<210>  4
<211>  219
<212>  PRT
<213>  Escherichia coli

<400>  4

Pro Pro Val Val Met Ser Arg Met Phe Gly Ala Gln Leu Phe Asn Gly 
1               5                   10                  15      


Thr Ser Ala Asp Ser Gly Ala Thr Val Gly Phe Asn Pro Asp Tyr Ile 
            20                  25                  30          


Leu Asn Pro Gly Asp Ser Ile Gln Val Arg Leu Trp Gly Ala Phe Thr 
        35                  40                  45              


Phe Asp Gly Ala Leu Gln Val Asp Pro Lys Gly Asn Ile Phe Leu Pro 
    50                  55                  60                  


Asn Val Gly Pro Val Lys Ile Ala Gly Val Ser Asn Ser Gln Leu Asn 
65                  70                  75                  80  


Ala Leu Val Thr Ser Lys Val Lys Glu Val Tyr Gln Ser Asn Val Asn 
                85                  90                  95      


Val Tyr Ala Ser Leu Leu Gln Ala Gln Pro Val Lys Val Tyr Val Thr 
            100                 105                 110         


Gly Phe Val Arg Asn Pro Gly Leu Tyr Gly Gly Val Thr Ser Asp Ser 
        115                 120                 125             


Leu Leu Asn Tyr Leu Ile Lys Ala Gly Gly Val Asp Pro Glu Arg Gly 
    130                 135                 140                 


Ser Tyr Val Asp Ile Val Val Lys Arg Gly Asn Arg Val Arg Ser Asn 
145                 150                 155                 160 


Val Asn Leu Tyr Asp Phe Leu Leu Asn Gly Lys Leu Gly Leu Ser Gln 
                165                 170                 175     


Phe Ala Asp Gly Asp Thr Ile Ile Val Gly Pro Arg Gln His Thr Phe 
            180                 185                 190         


Ser Val Gln Gly Asp Val Phe Asn Ser Tyr Asp Phe Glu Phe Arg Glu 
        195                 200                 205             


Ser Ser Ile Pro Val Thr Glu Ala Leu Ser Trp 
    210                 215                 


<210>  5
<211>  203
<212>  PRT
<213>  Thermotoga maritima

<400>  5

Leu Phe Leu Leu Ile Ala Val Phe Ser Leu Ser Tyr Thr Ile Arg Lys 
1               5                   10                  15      


Gly Asp Val Leu Arg Ile Glu Val Val Gly Tyr Pro Asp Leu Thr Arg 
            20                  25                  30          


Ser Cys Ala Val Asp Ile Glu Gly Ala Ile Thr Phe Pro Tyr Val Gly 
        35                  40                  45              


Arg Val Lys Val Glu Gly Leu Ser Val Asp Gln Val Thr Asp Leu Leu 
    50                  55                  60                  


Lys Glu Arg Leu Ser Arg Ser Phe Ser Glu Pro Glu Val Ile Val Ser 
65                  70                  75                  80  


Leu Gln Gln Ile Ala Pro Arg Asn Val Tyr Val Ser Gly Val Val Asn 
                85                  90                  95      


Arg Val Val Asn Met Gly Ile Glu Asp Leu Ser Val Ser Glu Leu Leu 
            100                 105                 110         


Ser Leu Leu Ser Val Asp Leu Ser Ser Val Asp Leu Ser Lys Val Lys 
        115                 120                 125             


Val Leu Arg Asp Gly Lys Val Phe Glu Leu Asp Leu Ser Ser Leu Leu 
    130                 135                 140                 


Trp Gly Glu Ala Pro Glu Lys Asp Val Met Leu Gln Glu Asn Asp Gln 
145                 150                 155                 160 


Val Ile Leu Pro Glu Lys Ser Tyr Thr Glu Phe Val Lys Ile Val Gly 
                165                 170                 175     


Ala Val Ser Lys Pro Gly Ile Tyr Pro Tyr Arg Arg Glu Met Thr Leu 
            180                 185                 190         


Leu Asp Ala Val Ala Ala Ala Gly Gly Thr Thr 
        195                 200             


<210>  6
<211>  121
<212>  PRT
<213>  Mycobacterium sp. JLS

<400>  6

Glu Thr Glu Arg Ser Asp Gly Leu Ser Asp Asn Tyr Leu Ile Ala Pro 
1               5                   10                  15      


Gly Asp Lys Leu Asn Ile Trp Ile Trp Gly Ala Val Asn Phe Ser Asn 
            20                  25                  30          


Val Val Thr Val Asp Asn Gln Gly Asn Ile Phe Ile Pro Asp Val Gly 
        35                  40                  45              


Pro Ile Asn Val Lys Asn Val Pro Ala Ser Gln Val Asn Gln Leu Val 
    50                  55                  60                  


Ala Ser Lys Ile Gly Asp Val Phe Thr Asn Asn Val Asn Thr Tyr Val 
65                  70                  75                  80  


Asn Leu Leu Thr Ala Thr Pro Val Ser Val Phe Val Thr Gly Pro Val 
                85                  90                  95      


Ile Arg Pro Gly Gln Tyr Ala Gly Gln Ser Ser Asp Ser Ile Leu Tyr 
            100                 105                 110         


Phe Leu Lys Arg Ala Gly Gly Ile Asp 
        115                 120     


<210>  7
<211>  121
<212>  PRT
<213>  Campylobacter jejuni

<400>  7

Lys Asn Tyr Asn Gln Arg Val Tyr Asn Pro Asp Tyr Lys Ile Ala Val 
1               5                   10                  15      


Gly Asp Gln Ile Ser Leu Lys Ile Trp Gly Ala Val Glu Phe Ser Gln 
            20                  25                  30          


Val Leu Val Val Asp Ser Gln Gly Asn Ile Phe Ile Pro Lys Val Gly 
        35                  40                  45              


Ala Val Asn Leu Leu Gly Val Lys Asn Ser Ala Leu Val Ser Val Ile 
    50                  55                  60                  


Lys Ala Arg Val Asn Lys Ile Tyr Lys Ser Asn Val Phe Val Tyr Ala 
65                  70                  75                  80  


Asp Met Asn Ala Tyr Gln Asn Val Ser Val Phe Val Thr Gly Asn Val 
                85                  90                  95      


Asn Ala Pro Gly Leu Tyr Gln Gly Leu Ser Ser Asp Ser Val Ile Gln 
            100                 105                 110         


Tyr Leu Asp Lys Ala Gly Gly Ile Asn 
        115                 120     


<210>  8
<211>  121
<212>  PRT
<213>  Escherichia coli

<400>  8

Asp Ser Gly Ala Thr Val Gly Phe Asn Pro Asp Tyr Ile Leu Asn Pro 
1               5                   10                  15      


Gly Asp Ser Ile Gln Val Arg Leu Trp Gly Ala Phe Thr Phe Asp Gly 
            20                  25                  30          


Ala Leu Gln Val Asp Pro Lys Gly Asn Ile Phe Leu Pro Asn Val Gly 
        35                  40                  45              


Pro Val Lys Ile Ala Gly Val Ser Asn Ser Gln Leu Asn Ala Leu Val 
    50                  55                  60                  


Thr Ser Lys Val Lys Glu Val Tyr Gln Ser Asn Val Asn Val Tyr Ala 
65                  70                  75                  80  


Ser Leu Leu Gln Ala Gln Pro Val Lys Val Tyr Val Thr Gly Phe Val 
                85                  90                  95      


Arg Asn Pro Gly Leu Tyr Gly Gly Val Thr Ser Asp Ser Leu Leu Asn 
            100                 105                 110         


Tyr Leu Ile Lys Ala Gly Gly Val Asp 
        115                 120     


<210>  9
<211>  120
<212>  PRT
<213>  Caulobacter crescentus

<400>  9

Gly Tyr Ala Asp Trp Ser Glu Ala Glu Pro Asp Tyr Arg Phe Tyr Pro 
1               5                   10                  15      


Gly Asp Glu Ile Glu Met Thr Val Pro Ser Ala Pro Glu Leu Asn Lys 
            20                  25                  30          


Thr Ala Thr Val Gln Pro Asp Gly Arg Ile Thr Val Pro Leu Val Gln 
        35                  40                  45              


Pro Val Met Ala Ala Asp Arg Thr Ile Gly Glu Leu Gln Ala Ser Leu 
    50                  55                  60                  


Ser Gln Ala Tyr Ala Gly Thr Leu Leu Arg Pro Gln Val Gln Ile Ser 
65                  70                  75                  80  


Val Lys Ala Thr Ala Pro Leu Lys Val Phe Val Gly Gly Glu Val Gly 
                85                  90                  95      


Asn Pro Gly Val Phe Asp Met Ala Gly Asp Gly Asp Ala Leu Arg Ala 
            100                 105                 110         


Ile Ile Gln Ala Gly Gly Phe Lys 
        115                 120 


<210>  10
<211>  120
<212>  PRT
<213>  Aquifex aeolicus

<400>  10

Val Ser Lys Leu Val Leu Pro Val Ser Glu Asn Tyr Lys Leu Gly Pro 
1               5                   10                  15      


Gly Asp Glu Val Ile Ile Tyr Ile Val Gly Leu Pro Ser Asn Gln Glu 
            20                  25                  30          


Ile Pro Pro Val Ile Lys Thr Ile Val Asp Arg Glu Gly Asn Ile Ser 
        35                  40                  45              


Ile Pro Asn Leu Gly Val Phe Asn Val Trp Gly Leu Thr Leu Lys Glu 
    50                  55                  60                  


Thr Glu Glu Leu Leu Arg Gln Glu Leu Gly Leu Asp Leu Lys Val Thr 
65                  70                  75                  80  


Val Gly Glu Ile Arg Thr Phe Val Ile Tyr Val Ala Gly Glu Val Asn 
                85                  90                  95      


Arg Pro Gly Thr His Val Ala Thr Ala Val Asn Thr Val Ile Asp Ala 
            100                 105                 110         


Leu Ser Ile Ala Gly Gly Val Lys 
        115                 120 


<210>  11
<211>  125
<212>  PRT
<213>  Synechocystis PCC6803

<400>  11

Asn Ala Pro Ser Ile Leu Pro Pro Glu Ser Glu Tyr Thr Leu Gly Pro 
1               5                   10                  15      


Gly Asp Arg Leu Arg Val Asp Val Leu Gln Val Glu Gly Leu Ser Gly 
            20                  25                  30          


Glu Tyr Gln Val Leu Val Asp Gly Thr Val Gly Phe Pro Leu Ile Gly 
        35                  40                  45              


Thr Val Arg Val Ala Gly Leu Thr Ile Pro Glu Leu Asn Gln Ile Leu 
    50                  55                  60                  


Val Ser Gln Tyr Ala Lys Tyr Ile Arg Arg Pro Leu Val Thr Ala Ile 
65                  70                  75                  80  


Leu Thr Val Pro Arg Pro Leu Ser Ile Thr Leu Ser Gly Glu Val Asn 
                85                  90                  95      


Ser Pro Gly Ala Tyr Ala Leu Ala Ile Glu Gly Gly Gln Lys Phe Pro 
            100                 105                 110         


Thr Leu Thr Gln Val Ile Gln Gln Ala Gly Gly Leu Thr 
        115                 120                 125 


<210>  12
<211>  132
<212>  PRT
<213>  Escherichia coli

<400>  12

Met Thr Leu Glu Ser Glu Ile Ala Asn Tyr Gln Tyr Arg Val Gly Pro 
1               5                   10                  15      


Gly Asp Val Leu Asn Val Thr Val Trp Asp His Pro Glu Leu Thr Thr 
            20                  25                  30          


Pro Ala Gly Gln Tyr Arg Ser Ser Ser Asp Thr Gly Asn Trp Val Gln 
        35                  40                  45              


Pro Asp Gly Thr Met Phe Tyr Pro Tyr Ile Gly Lys Val His Val Val 
    50                  55                  60                  


Gly Lys Thr Leu Ala Glu Ile Arg Ser Asp Ile Thr Gly Arg Leu Ala 
65                  70                  75                  80  


Thr Tyr Ile Ala Asp Pro Gln Val Asp Val Asn Ile Ala Ala Phe Arg 
                85                  90                  95      


Ser Gln Lys Ala Tyr Ile Ser Gly Gln Val Asn Lys Ser Gly Gln Gln 
            100                 105                 110         


Ala Ile Thr Asn Val Pro Leu Thr Ile Leu Asp Ala Ile Asn Ala Ala 
        115                 120                 125             


Gly Gly Leu Thr 
    130         


<210>  13
<211>  132
<212>  PRT
<213>  Escherichia coli

<400>  13

Pro Glu Leu Glu Gln Gln Ile Ala Asn Tyr Glu Tyr Arg Ile Gly Ile 
1               5                   10                  15      


Gly Asp Val Leu Met Val Thr Val Trp Asp His Pro Glu Leu Thr Thr 
            20                  25                  30          


Pro Ala Gly Gln Tyr Arg Ser Ala Ser Asp Thr Gly Asn Trp Val Asn 
        35                  40                  45              


Ala Asp Gly Ala Ile Phe Tyr Pro Tyr Ile Gly Arg Leu Lys Val Ala 
    50                  55                  60                  


Gly Lys Thr Leu Thr Gln Val Arg Asn Glu Ile Thr Ala Arg Leu Asp 
65                  70                  75                  80  


Ser Val Ile Glu Ser Pro Gln Val Asp Val Ser Val Ala Ala Phe Arg 
                85                  90                  95      


Ser Gln Lys Ala Tyr Val Thr Gly Glu Val Ser Lys Ser Gly Gln Gln 
            100                 105                 110         


Pro Ile Thr Asn Ile Pro Leu Thr Ile Met Asp Ala Ile Asn Ala Ala 
        115                 120                 125             


Gly Gly Leu Thr 
    130         


<210>  14
<211>  131
<212>  PRT
<213>  Mesorhizobium loti 

<400>  14

Ala Phe Leu Pro Gln Val Ala Ile Ser Gly Glu Tyr His Leu Gly Ser 
1               5                   10                  15      


Gln Asp Lys Leu Asn Ile Arg Ile Ala Glu Trp Gln Thr Val Glu Gly 
            20                  25                  30          


Thr Phe Arg Asp Trp Thr Ala Val Asn Gly Glu Tyr Thr Val Gly Pro 
        35                  40                  45              


Ala Gly Thr Leu Ser Val Pro Phe Val Gly Glu Leu Pro Ala Ala Gly 
    50                  55                  60                  


Lys Thr Thr Ala Glu Val Ala Ala Ala Ile Ser Glu Ala Leu Gln His 
65                  70                  75                  80  


Lys Leu Ala Leu Ser Asp Lys Pro Glu Ala Ser Val Glu Met Ala Gln 
                85                  90                  95      


Phe Arg Pro Phe Tyr Ile Ser Gly Glu Val Gln Asn Pro Gly Gln Phe 
            100                 105                 110         


Pro Phe Val Pro Asp Leu Thr Val Leu Lys Ala Ile Ser Val Ala Gly 
        115                 120                 125             


Gly Ile Arg 
    130     


<210>  15
<211>  131
<212>  PRT
<213>  Sinorhizobium meliloti

<400>  15

Ala Ser Gly Ala Ser Leu Ala Arg Ala Asp Glu Tyr Arg Leu Gly Val 
1               5                   10                  15      


Met Asp Lys Leu Arg Val Arg Val Ala Glu Trp Gln Thr Ala Glu Gly 
            20                  25                  30          


Ala Val Arg Asp Trp Ser Ala Val Ser Gly Asp Tyr Thr Val Gly Pro 
        35                  40                  45              


Ser Gly Ser Leu Ser Leu Pro Phe Val Gly Asp Leu Pro Ala Ser Gly 
    50                  55                  60                  


Lys Thr Thr Ser Glu Val Ala Glu Glu Ile Gly Val Lys Met Gln Lys 
65                  70                  75                  80  


Leu Phe Gly Leu Arg Asp Arg Pro Ser Ala Ser Val Glu Met Ala Gln 
                85                  90                  95      


Tyr Arg Pro Val Tyr Leu Ser Gly Glu Val Gln Thr Pro Gly Glu Tyr 
            100                 105                 110         


Pro Tyr Ala Pro Asn Leu Thr Val Leu Lys Ala Val Ser Leu Gly Gly 
        115                 120                 125             


Gly Leu Arg 
    130     


<210>  16
<211>  119
<212>  PRT
<213>  Caulobacter crescentus

<400>  16

Ala Pro Phe Ala Gly Ala Ala Gln Ala Val Asp Tyr Leu Leu Gly Pro 
1               5                   10                  15      


Gly Asp Lys Val Arg Val Thr Val Tyr Gly Glu Glu Ser Leu Ser Gly 
            20                  25                  30          


Glu Phe Phe Val Ala Gly Thr Gly Leu Met Ser Leu Pro Leu Ile Gly 
        35                  40                  45              


Glu Ile Lys Val Gly Gly Met Thr Val Gly Gln Phe Gln Thr Ala Val 
    50                  55                  60                  


Gln Asp Lys Leu Lys Asp Gly Tyr Leu Arg Asp Pro Arg Val Ser Ala 
65                  70                  75                  80  


Glu Val Leu Thr Phe Arg Pro Phe Tyr Ile Leu Gly Glu Val Glu Lys 
                85                  90                  95      


Pro Gly Thr Tyr Pro Tyr Thr Ser Gly Leu Thr Val Leu Asn Ala Val 
            100                 105                 110         


Ala Thr Ala Gly Gly Phe Thr 
        115                 


<210>  17
<211>  119
<212>  PRT
<213>  Vibrio cholerae

<400>  17

Trp Pro Ser Leu Ala Val Ala Asn Asp Asp Phe Tyr Arg Leu Gly Val 
1               5                   10                  15      


Gly Asp Gln Ile Arg Ile Gln Val Tyr Asp Glu Pro Glu Leu Ser Phe 
            20                  25                  30          


Glu Thr Arg Val Ser Asp Asn Gly Asn Ile Asp Tyr Pro Phe Leu Gly 
        35                  40                  45              


Arg Ile Arg Leu Lys Gly Lys Thr Leu Glu Glu Val Lys Thr Thr Ile 
    50                  55                  60                  


His Asp Gly Leu Leu Asp Gly Tyr Leu Ile Asn Pro Asn Val Ser Val 
65                  70                  75                  80  


Ser Ile Leu Glu Tyr Arg Pro Phe Phe Val Asn Gly Gln Val Met Lys 
                85                  90                  95      


Pro Gly Ser Tyr Pro Tyr His Pro Gly Leu Thr Val Asn Lys Ala Ile 
            100                 105                 110         


Thr Ile Ala Gly Gly Phe Thr 
        115                 


<210>  18
<211>  119
<212>  PRT
<213>  Mesorhizobium loti 

<400>  18

Pro Ala Ala Phe His Glu Val Leu Asp Gln Pro Tyr Arg Leu Gly Ala 
1               5                   10                  15      


Gly Asp Arg Val Arg Val Thr Val Phe Glu Gln Glu Gly Leu Thr Asn 
            20                  25                  30          


Thr Tyr Ser Val Asp Gln Ser Gly Tyr Leu Ser Phe Pro Leu Val Gly 
        35                  40                  45              


Ala Ile Pro Ala Arg Gly His Thr Ala Gln Gln Met Glu Lys Glu Ile 
    50                  55                  60                  


Ala Asp Lys Leu Arg Gln Gly Tyr Leu Arg Asp Pro Asp Val Ser Val 
65                  70                  75                  80  


Glu Ile Asp Arg Tyr Arg Pro Ile Phe Val Met Gly Glu Val Gly Ala 
                85                  90                  95      


Ala Gly Gln Tyr Ser Tyr Val Pro Gly Leu Thr Val Gln Lys Ala Ile 
            100                 105                 110         


Ala Ile Ala Gly Gly Phe Ser 
        115                 


<210>  19
<211>  122
<212>  PRT
<213>  Xylella fastidiosa

<400>  19

Asp Ala Leu Leu Phe Pro Gln Val Gln Pro Glu Tyr Lys Val Ser Pro 
1               5                   10                  15      


Gly Asp Leu Leu Leu Ile Lys Val Phe Gln Val Asp Asp Leu Glu Arg 
            20                  25                  30          


Gln Val Arg Val Asp Asn Thr Gly Arg Ile Thr Leu Pro Leu Leu Gly 
        35                  40                  45              


Ser Ile Asp Val Ser Asn Lys Gly Ala Ala Glu Leu Glu Thr Leu Ile 
    50                  55                  60                  


Ala Asn Arg Tyr Arg Ser Gly Tyr Leu Gln Asn Pro Gln Val Ser Val 
65                  70                  75                  80  


Phe Ile Gln Glu Ala Asn Ala Arg Arg Val Thr Val Thr Gly Ala Val 
                85                  90                  95      


Thr Glu Pro Gly Ser Tyr Pro Leu Ile Gly Ser Asn Leu Thr Leu Gln 
            100                 105                 110         


Gln Val Ile Ala Gln Ala Lys Gly Ile Asn 
        115                 120         


<210>  20
<211>  122
<212>  PRT
<213>  Xanthomonas campestris

<400>  20

Asp Pro Leu Ala Met Ser Thr Val Gln Pro Glu Tyr Arg Leu Ala Pro 
1               5                   10                  15      


Gly Asp Leu Leu Leu Val Lys Val Phe Gln Ile Asp Asp Leu Glu Arg 
            20                  25                  30          


Gln Val Arg Ile Asp Gln Asn Gly His Ile Ser Leu Pro Leu Ile Gly 
        35                  40                  45              


Asp Val Lys Ala Ala Gly Leu Gly Val Gly Glu Leu Glu Lys Leu Val 
    50                  55                  60                  


Ala Asp Arg Tyr Arg Ala Gly Tyr Leu Gln Gln Pro Gln Ile Ser Val 
65                  70                  75                  80  


Phe Val Gln Glu Ser Asn Gly Arg Arg Val Thr Val Thr Gly Ala Val 
                85                  90                  95      


Asp Glu Pro Gly Ile Tyr Pro Val Ile Gly Ala Asn Leu Thr Leu Gln 
            100                 105                 110         


Gln Ala Ile Ala Gln Ala Lys Gly Val Ser 
        115                 120         


<210>  21
<211>  122
<212>  PRT
<213>  Unknown

<220>
<223>  PES Domain

<400>  21

Thr Pro Pro Ala Ala Gly Ala Ala Pro Ala Gly Tyr Lys Ile Gly Val 
1               5                   10                  15      


Asp Asp Val Ile Glu Ala Asp Val Leu Gly Gln Ser Asp Phe Lys Thr 
            20                  25                  30          


Arg Ala Arg Val Gln Ala Asp Gly Thr Val Thr Leu Pro Tyr Leu Gly 
        35                  40                  45              


Ala Val Gln Val Arg Gly Glu Thr Ala Val Thr Leu Ala Glu Lys Leu 
    50                  55                  60                  


Ala Gly Leu Leu Arg Ala Gly Gly Tyr Tyr Ala Lys Pro Ile Val Ser 
65                  70                  75                  80  


Val Glu Val Val Ser Phe Val Ser Asn Tyr Val Thr Val Leu Gly Gln 
                85                  90                  95      


Val Thr Thr Ala Gly Leu Gln Pro Val Asp Arg Gly Tyr His Val Ser 
            100                 105                 110         


Glu Ile Ile Ala Arg Ala Gly Gly Leu Arg 
        115                 120         


<210>  22
<211>  133
<212>  PRT
<213>  Mesorhizobium loti 

<400>  22

Thr Ser Met Ala Ala Ala Gly Glu Ala Glu Pro Tyr Gln Leu Ser Pro 
1               5                   10                  15      


Gly Asp Thr Val Glu Ile Gly Ile Ala Ala Ile Pro Asp Arg Ala Gln 
            20                  25                  30          


Arg Ala Val Val Gln Met Asp Gly Asn Ile Ala Leu Pro Glu Val Gly 
        35                  40                  45              


Met Ile Met Val Ala Gly Leu Thr Ala Ser Gln Leu Gln Thr Arg Met 
    50                  55                  60                  


Gln Ala Leu Leu Pro Thr Lys Ile Phe His Val Arg Leu Ala Asp Gly 
65                  70                  75                  80  


Arg Glu Gln Met Val Val Val Lys Pro Asp Asp Val Thr Ala Ile Ile 
                85                  90                  95      


Val Asp Tyr Arg Pro Ile Tyr Val Met Gly Asp Val Leu Thr Pro Gly 
            100                 105                 110         


Gln Gln Ala Tyr Arg Pro Leu Met Thr Val Arg Gln Ala Leu Ala Val 
        115                 120                 125             


Ser Gly Gly Phe Ser 
    130             


<210>  23
<211>  118
<212>  PRT
<213>  Brucella melitensis

<400>  23

Thr Gly Gly Leu Ala Ala Ala Asp Gly Asn Ile Tyr Arg Val Gly Ala 
1               5                   10                  15      


Asn Asp Val Leu Gln Val Thr Val Tyr Gly Gln Pro Ala Leu Thr Gly 
            20                  25                  30          


Leu Tyr Pro Val Asp Val Asp Gly Asn Ile Gly Tyr Pro Val Val Gly 
        35                  40                  45              


Asn Ile Ser Val Gln Gly Leu Thr Thr Leu Gln Ile Ser Glu Lys Ile 
    50                  55                  60                  


Ala Ser Ser Leu Ser Gln His Ile Pro Gly Leu Thr Val Thr Ala Thr 
65                  70                  75                  80  


Ile Asn Gln Tyr Ala Pro Val Phe Val Met Gly Asp Val Lys Ala Pro 
                85                  90                  95      


Gly Lys Tyr Glu Phe Arg Pro Gly Met Val Ala Leu Glu Leu Met Ala 
            100                 105                 110         


Leu Gly Gly Gly Ala Gly 
        115             


<210>  24
<211>  132
<212>  PRT
<213>  Sinorhizobium meliloti

<400>  24

Arg Arg Phe Gly Ile Gly Gly Val Val Gly Gln Val Val Ile Gly Ile 
1               5                   10                  15      


Gly Asp Gln Leu Lys Val Thr Ile Phe Glu Ala Gly Ser Asp Gly Leu 
            20                  25                  30          


Phe Ser Thr Thr Glu Ser Lys Gln Thr Ser Ile Asp Leu Val Val Gln 
        35                  40                  45              


Pro Asp Gly Lys Ala Ala Ile Pro Tyr Val Gly Ser Val Arg Phe Ala 
    50                  55                  60                  


Gly Leu Thr Leu Glu Gln Ala Arg Gln Ala Ile Leu Asp Ala Leu Lys 
65                  70                  75                  80  


Gln Lys Ala Val Glu Pro Asp Val Ile Val Thr Ser Thr Ser Thr Ala 
                85                  90                  95      


Ser Arg Ile Val Thr Val Ser Gly Ala Val Gly Arg Pro Ser Val Val 
            100                 105                 110         


Pro Leu Asn Leu Val Ser Glu Thr Ile Asn Glu Val Ile Ala Lys Ala 
        115                 120                 125             


Gly Gly Pro Ser 
    130         


<210>  25
<211>  122
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  25

Met Glu Arg Val Arg Val Gly Asp Thr Leu Arg Ile Val Arg Asp Ala 
1               5                   10                  15      


Gly Glu Met Pro Thr Leu Ser Ala Phe Asn Val Ala Thr Ile Tyr Glu 
            20                  25                  30          


Leu Thr Leu Tyr Thr Val Leu Asn Asp Gly Ser Ile Tyr Tyr Pro Phe 
        35                  40                  45              


Ile Gly Arg Ile Gln Ala Ala His Arg Thr Pro Gln Glu Ile Ala Asn 
    50                  55                  60                  


Glu Leu Thr Thr Lys Leu Ala Pro Ile Tyr Arg Glu Pro Arg Val Thr 
65                  70                  75                  80  


Val Asn Ile Asn Gln Ala Pro Gly Asn Thr Val Phe Val Gly Gly Ala 
                85                  90                  95      


Val Arg Asn Pro Ser Ala Val Pro Ile Pro Ala Ala Asn Asn Met Glu 
            100                 105                 110         


Gln Ala Ile Leu Gly Ala Gly Gly Ile Leu 
        115                 120         


<210>  26
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide Primer

<400>  26
aggaggaatt catgaagaaa aaacttgtta gattttgc                             38


<210>  27
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide Primer

<400>  27
gcatgcctgc agttacttgt cgtcgtcgtc cttgtagtcg ttgggccatc tcttaatgta     60

tc                                                                    62


