                         SEQUENCE LISTING

<110>  GONG, Da-Wei
       McLENITHAN, John
       SHULDINER, Alan
       YANG, Rong-Ze
 
<120>  USE OF OMENTIN 1 AND OMENTIN 2 IN THE DIAGNOSIS AND TREATMENT OF 
       DISEASE

<130>  70089.0018WOU1

<150>  US 60/848,520
<151>  2006-09-29

<160>  14    

<170>  PatentIn version 3.4

<210>  1
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Gln Leu Ser Phe Leu Leu Phe Leu Ile Ala Thr Thr Arg Gly 
1               5                   10                  15      


Trp Ser Thr Asp Glu Ala Asn Thr Tyr Phe Lys Glu Trp Thr Cys Ser 
            20                  25                  30          


Ser Ser Pro Ser Leu Pro Arg Ser Cys Lys Glu Ile Lys Asp Glu Cys 
        35                  40                  45              


Pro Ser Ala Phe Asp Gly Leu Tyr Phe Leu Arg Thr Glu Asn Gly Val 
    50                  55                  60                  


Ile Tyr Gln Thr Phe Cys Asp Met Thr Ser Gly Gly Gly Gly Trp Thr 
65                  70                  75                  80  


Leu Val Ala Ser Val His Glu Asn Asp Met Arg Gly Lys Cys Thr Val 
                85                  90                  95      


Gly Asp Arg Trp Ser Ser Gln Gln Gly Ser Lys Ala Val Tyr Pro Glu 
            100                 105                 110         


Gly Asp Gly Asn Trp Ala Asn Tyr Asn Thr Phe Gly Ser Ala Glu Ala 
        115                 120                 125             


Ala Thr Ser Asp Asp Tyr Lys Asn Pro Gly Tyr Tyr Asp Ile Gln Ala 
    130                 135                 140                 


Lys Asp Leu Gly Ile Trp His Val Pro Asn Lys Ser Pro Met Gln His 
145                 150                 155                 160 


Trp Arg Asn Ser Ser Leu Leu Arg Tyr Arg Thr Asp Thr Gly Phe Leu 
                165                 170                 175     


Gln Thr Leu Gly His Asn Leu Phe Gly Ile Tyr Gln Lys Tyr Pro Val 
            180                 185                 190         


Lys Tyr Gly Glu Gly Lys Cys Trp Thr Asp Asn Gly Pro Val Ile Pro 
        195                 200                 205             


Val Val Tyr Asp Phe Gly Asp Ala Gln Lys Thr Ala Ser Tyr Tyr Ser 
    210                 215                 220                 


Pro Tyr Gly Gln Arg Glu Phe Thr Ala Gly Phe Val Gln Phe Arg Val 
225                 230                 235                 240 


Phe Asn Asn Glu Arg Ala Ala Asn Ala Leu Cys Ala Gly Met Arg Val 
                245                 250                 255     


Thr Gly Cys Asn Thr Glu His His Cys Ile Gly Gly Gly Gly Tyr Phe 
            260                 265                 270         


Pro Glu Ala Ser Pro Gln Gln Cys Gly Asp Phe Ser Gly Phe Asp Trp 
        275                 280                 285             


Ser Gly Tyr Gly Thr His Val Gly Tyr Ser Ser Ser Arg Glu Ile Thr 
    290                 295                 300                 


Glu Ala Ala Val Leu Leu Phe Tyr Arg 
305                 310             


<210>  2
<211>  1284
<212>  DNA
<213>  Homo sapiens

<400>  2
ggcattgtgc caggggaggg tgaggctgga aaccttggtt ggccccactg ggcttcctcc     60

ataaagcttt ctgcacctca ttccacatca ggagcgtttt tggagaaagc tgcactctgt    120

tgagctccag ggcgcagtgg agggagggag tgaaggagct ctctgtaccc aaggaaagtg    180

cagctgagac tcagacaaga ttacaatgaa ccaactcagc ttcctgctgt ttctcatagc    240

gaccaccaga ggatggagta cagatgaggc taatacttac ttcaaggaat ggacctgttc    300

ttcgtctcca tctctgccca gaagctgcaa ggaaatcaaa gacgaatgtc ctagtgcatt    360

tgatggcctg tattttctcc gcactgagaa tggtgttatc taccagacct tctgtgacat    420

gacctctggg ggtggcggct ggaccctggt ggccagcgtg catgagaatg acatgcgtgg    480

gaagtgcacg gtgggcgatc gctggtccag tcagcagggc agcaaagcag actacccaga    540

gggggacggc aactgggcca actacaacac ctttggatct gcagaggcgg ccacgagcga    600

tgactacaag aaccctggct actacgacat ccaggccaag gacctgggca tctggcacgt    660

gcccaataag tcccccatgc agcactggag aaacagctcc ctgctgaggt accgcacgga    720

cactggcttc ctccagacac tgggacataa tctgtttggc atctaccaga aatatccagt    780

gaaatatgga gaaggaaagt gttggactga caacggcccg gtgatccctg tggtctatga    840

ttttggcgac gcccagaaaa cagcatctta ttactcaccc tatggccagc gggaattcac    900

tgcgggattt gttcagttca gggtatttaa taacgagaga gcagccaacg ccttgtgtgc    960

tggaatgagg gtcaccggat gtaacactga gcaccactgc attggtggag gaggatactt   1020

tccagaggcc agtccccagc agtgtggaga tttttctggt tttgattgga gtggatatgg   1080

aactcatgtt ggttacagca gcagccgtga gataactgag gcagctgtgc ttctattcta   1140

tcgttgagag ttttgtggga gggaacccag acctctcctc ccaaccatga gatcccaagg   1200

atggagaaca acttacccag tagctagaat gttaatggca gaagagaaaa caataaatca   1260

tattgactca aaaaaaaaaa aaaa                                          1284


<210>  3
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Ser Met Leu Arg Thr Met Thr Arg Leu Cys Phe Leu Leu Phe 
1               5                   10                  15      


Phe Ser Val Ala Thr Ser Gly Cys Ser Ala Ala Ala Ala Ser Ser Leu 
            20                  25                  30          


Glu Met Leu Ser Arg Glu Phe Glu Thr Cys Ala Phe Ser Phe Ser Ser 
        35                  40                  45              


Leu Pro Arg Ser Cys Lys Glu Ile Lys Glu Arg Cys His Ser Ala Gly 
    50                  55                  60                  


Asp Gly Leu Tyr Phe Leu Arg Thr Lys Asn Gly Val Val Tyr Gln Thr 
65                  70                  75                  80  


Phe Cys Asp Met Thr Ser Gly Gly Gly Gly Trp Thr Leu Val Ala Ser 
                85                  90                  95      


Val His Glu Asn Asp Met Arg Gly Lys Cys Thr Val Gly Asp Arg Trp 
            100                 105                 110         


Ser Ser Gln Gln Gly Asn Lys Ala Asp Tyr Pro Glu Gly Asp Gly Asn 
        115                 120                 125             


Trp Ala Asn Tyr Asn Thr Phe Gly Ser Ala Glu Ala Ala Thr Ser Asp 
    130                 135                 140                 


Asp Tyr Lys Asn Pro Gly Tyr Tyr Asp Ile Gln Ala Lys Asp Leu Gly 
145                 150                 155                 160 


Ile Trp His Val Pro Asn Lys Ser Pro Met Gln His Trp Arg Asn Ser 
                165                 170                 175     


Ala Leu Leu Arg Tyr Arg Thr Asn Thr Gly Phe Leu Gln Arg Leu Gly 
            180                 185                 190         


His Asn Leu Phe Gly Ile Tyr Gln Lys Tyr Pro Val Lys Tyr Arg Ser 
        195                 200                 205             


Gly Lys Cys Trp Asn Asp Asn Gly Pro Ala Ile Pro Val Val Tyr Asp 
    210                 215                 220                 


Phe Gly Asp Ala Lys Lys Thr Ala Ser Tyr Tyr Ser Pro Tyr Gly Gln 
225                 230                 235                 240 


Arg Glu Phe Val Ala Gly Phe Val Gln Phe Arg Val Phe Asn Asn Glu 
                245                 250                 255     


Arg Ala Ala Asn Ala Leu Cys Ala Gly Ile Lys Val Thr Gly Cys Asn 
            260                 265                 270         


Thr Glu His His Cys Ile Gly Gly Gly Gly Phe Phe Pro Gln Gly Lys 
        275                 280                 285             


Pro Arg Gln Cys Gly Asp Phe Ser Ala Phe Asp Trp Asp Gly Tyr Gly 
    290                 295                 300                 


Thr His Val Lys Ser Ser Cys Ser Arg Glu Ile Thr Glu Ala Ala Val 
305                 310                 315                 320 


Leu Leu Phe Tyr Arg 
                325 


<210>  4
<211>  1150
<212>  DNA
<213>  Homo sapiens

<400>  4
gcaggggagc tccgagtgtc cacaggaagg gaactatcag ctcctggcat ctgtaaggat     60

gctgtccatg ctgaggacaa tgaccagact ctgcttcctg ttattcttct ctgtggccac    120

cagtgggtgc agtgcagcag cagcctcttc tcttgagatg ctctcgaggg aattcgaaac    180

ctgtgccttc tccttttctt ccctgcctag aagctgcaaa gaaatcaagg aacgctgcca    240

tagtgcaggt gatggcctgt attttctccg caccaagaat ggtgttgtct accagacctt    300

ctgtgacatg acttctgggg gtggcggctg gaccctggtg gccagcgtgc acgagaatga    360

catgcgtggg aagtgcacgg tgggtgatcg ctggtccagt cagcagggca acaaagcaga    420

ctacccagag ggggatggca actgggccaa ctacaacacc tttggatctg cagaggcggc    480

cacgagcgat gactacaaga accctggcta ctacgacatc caggccaagg acctgggcat    540

ctggcatgtg cccaacaagt cccccatgca gcattggaga aacagcgccc tgctgaggta    600

ccgcaccaac actggcttcc tccagagact gggacataat ctgtttggca tctaccagaa    660

atacccagtg aaatacagat cagggaaatg ttggaatgac aatggcccag ccatacctgt    720

ggtctatgac tttggtgatg ctaagaagac tgcatcttat tactcaccgt atggtcaacg    780

ggaatttgtt gcaggattcg ttcagttccg ggtgtttaat aacgagagag cagccaacgc    840

cctttgtgct gggataaaag ttactggctg taacactgag catcactgca tcggtggagg    900

agggttcttc ccacagggca aaccccgtca gtgtggggac ttctccgcct ttgactggga    960

tggatatgga actcacgtta agagcagctg cagtcgggag ataacggagg cggctgtact   1020

cttgttctat agatgagaca gagctctgcg gtgtcagggc gagaacccat cttccaaccc   1080

cggctatttg gagacggaaa aactggaatt ctaacaagga ggagaggaga ctaaatcaca   1140

tcaatttgca                                                          1150


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized omentin 1 peptide

<400>  5

Thr Thr Arg Gly Trp Ser Thr Asp Glu Ala Asn Thr Tyr Phe Cys 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized omentin 1 peptide

<400>  6

Ser Gln Gln Gly Ser Lys Ala Val Tyr Pro Glu Gly Asp Gly Cys 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized omentin 1 peptide

<400>  7

Gly Ser Ala Glu Ala Ala Thr Ser Asp Asp Tyr Lys Asn Pro Cys 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized omentin 1 peptide

<400>  8

Val Pro Asn Lys Ser Pro Met Gln His Trp Arg Asn Ser Ser Cys 
1               5                   10                  15  


<210>  9
<211>  2102
<212>  DNA
<213>  Homo sapiens

<400>  9
agttaacagg ctggctcggt ggttcacgcc cgtaatccta gcacttgggc aagctgaggc     60

aggaggatca aggtcaggag ttctggagta gcctgggtaa catggggaga ccccgtttct    120

acagaaaaga aaagagtttt ttttgttttt tgtttttttt gagatggagt ttcactcttg    180

ttgcccaggc tggagtgcaa tggtgtgatc tcggctcact gcaacctccg cctcctggat    240

tcaggtgatt ctcctgcctc agcctcctga gtagctggga ttacaggcat gcaccaccac    300

gaccggctaa ttttgtattt ttagtagaga ccgggtttct ccatgttggt caggctggtc    360

tcgatctttt gacctcagat gatccaccca cctcggcctc ccaaagtgct gggattacag    420

gcgtgagcca ccgcgcccag cccaaaaaaa gagtttttaa taatatgatg ttgataattg    480

tactgtggtt atacatgaca tattcctatt attagaaaac acactagttg gccaggcatg    540

gtggcttaca cctataatcc cagcacttgg gaggccgagg caggtggatc acgaggtcac    600

gagttcaaga ccagcctggc caagatggca aaaccccgta tctactaaaa atacaaaaat    660

tagctgggcg tggtggtggg tgcctgtaat cccagttact cgggaggctg agacaggaga    720

atcacttgaa cctgggaggc gggggttgca gtaagctgag accatgccat tgcactccaa    780

cctgggtgac agagtgaggc tctgtgtcaa aaaacaaaac aaaataaaaa aaacccatac    840

gcatttattt aaaggtaaaa gcccatgatg tatgtacctt accttcaaat ggttcagaaa    900

aaaattttgt gtgtgtgggt gtattttata tacatatatc tatatatata tagagagaga    960

gagagagaac acgaaagata aagcaaatgg ggtgaaatat taacaatagt tgaatctagg   1020

taaagggcat atatgtggct ttatattatt gttatttttg caacatttaa taaatttcaa   1080

attgtttcta aacagagtta ataaaacaat aaaattacag caggatacat gcaataatta   1140

gtgtttggac agtgtatagt gtggacaaag gaaggatcca tcagctttgt ctggtgatgg   1200

gggtgtcagg gaaggcctca tagagaaatt ggaggaaaga ttggaaggat gatgtcttct   1260

tttcccattt atttattatt attattatta ttattatttt gaggtgaagt cttgctctgt   1320

tgcccaggct ggagtgcagt ggagcagtct tggctcactg caacctccac ctcctgggtt   1380

caagcagttc tcctgtctca gcctccagag tagctgggat tacgggtgca cgccactgca   1440

cccagctaaa tttttgtatt tttagtagag acagggttgc accatgttgg ctggtcttga   1500

actcctgacc tcaggtaatc cgcccacctc ggcctcccaa agcgctatga ttataggtgt   1560

gagccactgt gcctggccaa ttattattct taattaatta atttattttt catgaggtgt   1620

cacctcagtc taaaaggatg atttcttgac agagttgtgt ctagggggcc agggcatctg   1680

ggggaggtgg gagagggaga acgcagggga ggattgtgac ctatccacga atctgattag   1740

atactgctac attgtatggc ctgccttggc aaagcaggat gcccctcctc agatggcgac   1800

agtcacctgt gtggccagga acacagctcc ctgctcctcc agccagtcgc acgtcctttc   1860

tcatttccac ggtcccaggc tcaggtaccc tcagagggaa gggcttcaga gggaggggct   1920

agcagcctag gctgctcagg gttgggctgg gcagggctca ggtggtttgg ctctccacag   1980

ctctccacat aaagggacca gcacttcacc cttcatcagg atcctctgca ggggagctcc   2040

gagtgtccac aggaagggaa ctatcagctc ctggcatctg taaggatgct gtccatgctg   2100

gt                                                                  2102


<210>  10
<211>  1384
<212>  DNA
<213>  Homo sapiens

<400>  10
atacctgtgg tctatgactt tggtgatgct aagaagactg catcttatta ctcaccgtat     60

ggtcaacgtg agtgtttgct ccctaagtcc agtcataaat attttcttgt actcttggag    120

aatggtggca aataacaaca attaataatt gctagtattt actgagcact taaaatgcac    180

cagactcttg tcttggaact taacatgatt ttgtgtcatt taattaccat gagaaaacta    240

tgaagttaga attgctgtta tccccatttc acagcacgta atcccaggtt tcttcatcac    300

caccttgtat actcttataa ttgtggggaa aagaaaaaga gatcagactg ttactgtgtc    360

tatgtagaaa gaagtagaca taagagactc cattttggtc tgtgctgaga aaaattcttc    420

tgccttgaga tgctgttaat ctgtaaccct acccccaacc ctgtgctcac agagacatgt    480

gctgtgttga ctcacggttt aatggattta gggctgtgca ggatgtgctt tgttaaacaa    540

gtgcttgaag gcagcatgct tgttaaaggt catcaccact ctctaatctc aagtacccag    600

ggacacaata cactgcggaa ggccgcaggg acctctgtct aggaaagcca ggtattgtcc    660

aaggtttctc cccatgtgat agcctgagat atggcctcgt gggaagggaa agacctgact    720

gtcccccagc ccgacaccca caaagggtct gtgctgagga ggattagtaa aagaggaagg    780

cctctttgca gttgagataa gaggaaggca tctgtcttct gcttatccct gggcaatgga    840

atgttttggt gtaaaacccg attgtatgtt ctatttactg agataggaga aaaccacctt    900

agggctggag gtgagacatg ctggcggcaa tactgctttt taatgcaccg agatgtttat    960

gtatgtgcac gtcaaaagca cagcaccttt tcttaacctt gtttatgaca cagacatttg   1020

ttcacatgtt ttcctgctga ccctctcccc actattaccc tattgtcctg ccacgtcccc   1080

ctctctgaga tggtagagat aatgatcaat aaatactgag ggaactcaga gactggtgct   1140

ggtgcgggtc ctccttatgc tgagcgccag tcccctgggc ccacttttct ttctctatac   1200

tttgtcgctg tgtctctttc ttttctcagt ctctcgttcc acccaacgag gaacacccac   1260

aggtgtggag gggcaggcca ccccttcaat aatagttaag aaaaggtgca tacaaaacat   1320

tagctgggca tgatggcgca tgcctgtaat cccagctcct cgggaggctg aggcaggaga   1380

atct                                                                1384


<210>  11
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized amplification primer

<400>  11
ctccagacac tgggacata                                                  19


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized amplification primer

<400>  12
tgaccctcat tccagcaca                                                  19


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized amplification primer

<400>  13
cgacctggaa gtccaactac                                                 20


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized amplification primer

<400>  14
atctgctgca tctgcttg                                                   18


1/9

