
                                SEQUENCE LISTING

<110> Yang, Lili
      Baltimore, David
      Wang, Pin
      Economou, James
      Ribas, Antoni

<120> MART-1 T CELL RECEPTORS FOR THE
  TREATMENT OF CANCER

<130> CALTE.037A

<150> US 60/848,207       
<151> 2006-09-29  

<160> 21

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 825
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cloned nucleic acid sequence

<400> 1
atgatgaaat ccttgagagt tttactggtg atcctgtggc ttcagttaag ctgggtttgg 60
agccaacaga aggaggtgga gcaggatcct ggaccactca gtgttccaga gggagccatt 120
gtttctctca actgcactta cagcaacagt gcttttcaat acttcatgtg gtacagacag 180
tattccagaa aaggccctga gttgctgatg tacacatact ccagtggtaa caaagaagat 240
ggaaggttta cagcacaggt cgataaatcc agcaagtata tctccttgtt catcagagac 300
tcacagccca gtgattcagc cacctacctc tgtgcaatga gcgagactgg aggcttcaaa 360
actatctttg gagcaggaac aagactattt gttaaagcaa atatccagaa ccctgaccct 420
gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat 480
tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa 540
actgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac 600
aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc 660
ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat 720
acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg 780
gccgggttta atctgctcat gacgctgcgg ctgtggtcca gctga                 825

<210> 2
<211> 347
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cloned nucleic acid sequence

<400> 2
gggtttggag ccaacagaag gaggtggagc aggatcctgg accactcagt gttccagagg 60
gagccattgt ttctctcaac tgcacttaca gcaacagtgc ttttcaatac ttcatgtggt 120
acagacagta ttccagaaaa ggccctgagt tgctgatgta cacatactcc agtggtaaca 180
aagaagatgg aaggtttaca gcacaggtcg ataaatccag caagtatatc tccttgttca 240
tcagagactc acagcccagt gattcagcca cctacctctg tgcaatgagc gagactggag 300
gcttcaaaac tatctttgga gcaggaacaa gactatttgt taaagca               347

<210> 3
<211> 274
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein expressed from cloned nucleic acid
      sequence

<400> 3
Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu
 1               5                  10                  15      
Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro
            20                  25                  30          
Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser
        35                  40                  45              
Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys
    50                  55                  60                  
Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp
65                  70                  75                  80  
Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu
                85                  90                  95      
Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala
            100                 105                 110         
Met Ser Glu Thr Gly Gly Phe Lys Thr Ile Phe Gly Ala Gly Thr Arg
        115                 120                 125             
Leu Phe Val Lys Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln
    130                 135                 140                 
Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp
145                 150                 155                 160 
Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr
                165                 170                 175     
Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser
            180                 185                 190         
Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn
        195                 200                 205             
Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro
    210                 215                 220                 
Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp
225                 230                 235                 240 
Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu
                245                 250                 255     
Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp
            260                 265                 270         
Ser Ser
        


<210> 4
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein expressed from cloned nucleic acid
      sequence

<400> 4
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro Leu
 1               5                  10                  15      
Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser Asn
            20                  25                  30          
Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys Gly
        35                  40                  45              
Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp Gly
    50                  55                  60                  
Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu Phe
65                  70                  75                  80  
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Met
                85                  90                  95      
Ser Glu Thr Gly Gly Phe Lys Thr Ile Phe Gly Ala Gly Thr Arg Leu
            100                 105                 110         
Phe Val Lys Ala
        115     


<210> 5
<211> 933
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cloned nucleic acid sequence

<400> 5
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa 60
gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg 120
acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg 180
ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct 240
gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc 300
agccccaacc agacctctct gtacttctgt gccagcagtt tagtagggac agcggggtca 360
cccctccact ttgggaacgg gaccaggctc actgtgacag aggacctgaa caaggtgttc 420
ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc 480
acactggtgt gcctggccac aggcttcttc cctgaccacg tggagctgag ctggtgggtg 540
aatgggaagg aggtgcacag tggggtcagc acggacccgc agcccctcaa ggagcagccc 600
gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg 660
cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac 720
gagtggaccc aggatagggc caaacccgtc acccagatcg tcagcgccga ggcctggggt 780
agagcagact gtggctttac ctcggtgtcc taccagcaag gggtcctgtc tgccaccatc 840
ctctatgaga tcctgctagg gaaggccacc ctgtatgctg tgctggtcag cgcccttgtg 900
ttgatggcca tggtcaagag aaaggatttc tga                              933

<210> 6
<211> 350
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cloned nucleic acid sequence

<400> 6
gccccctgga agcccaagtg acccagaacc caagatacct catcacagtg actggaaaga 60
agttaacagt gacttgttct cagaatatga accatgagta tatgtcctgg tatcgacaag 120
acccagggct gggcttaagg cagatctact attcaatgaa tgttgaggtg actgataagg 180
gagatgttcc tgaagggtac aaagtctctc gaaaagagaa gaggaatttc cccctgatcc 240
tggagtcgcc cagccccaac cagacctctc tgtacttctg tgccagcagt ttagtaggga 300
cagcggggtc acccctccac tttgggaacg ggaccaggct cactgtgaca            350

<210> 7
<211> 310
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein expressed from cloned nucleic acid
      sequence

<400> 7
Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala
 1               5                  10                  15      
Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr
            20                  25                  30          
Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His
        35                  40                  45              
Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln
    50                  55                  60                  
Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro
65                  70                  75                  80  
Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile
                85                  90                  95      
Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser
            100                 105                 110         
Ser Leu Val Gly Thr Ala Gly Ser Pro Leu His Phe Gly Asn Gly Thr
        115                 120                 125             
Arg Leu Thr Val Thr Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val
    130                 135                 140                 
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160 
Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu
                165                 170                 175     
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp
            180                 185                 190         
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205             
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220                 
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240 
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255     
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln
            260                 265                 270         
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285             
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300                 
Val Lys Arg Lys Asp Phe
305                 310 


<210> 8
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein expressed from cloned nucleic acid
      sequence

<400> 8
Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr
 1               5                  10                  15      
Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His
            20                  25                  30          
Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln
        35                  40                  45              
Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro
    50                  55                  60                  
Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile
65                  70                  75                  80  
Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser
                85                  90                  95      
Ser Leu Val Gly Thr Ala Gly Ser Pro Leu His Phe Gly Asn Gly Thr
            100                 105                 110         
Arg Leu Thr Val Thr
        115         


<210> 9
<211> 825
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cloned nucleic acid sequence

<400> 9
atgatgaaat ccttgagagt tttactagtg atcctgtggc ttcagttgag ctgggtttgg 60
agccaacaga aggaggtgga gcagaattct ggacccctca gtgttccaga gggagccatt 120
gcctctctca actgcactta cagtgaccga ggttcccagt ccttcttctg gtacagacaa 180
tattctggga aaagccctga gttgataatg ttcatatact ccaatggtga caaagaagat 240
ggaaggttta cagcacagct caataaagcc agccagtatg tttctctgct catcagagac 300
tcccagccca gtgattcagc cacctacctc tgtgccgtga acataggctt tgggaatgtg 360
ctgcattgcg ggtccggcac tcaagtgatt gttttaccac atatccagaa ccctgaccct 420
gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat 480
tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa 540
actgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac 600
aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc 660
ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat 720
acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg 780
gccgggttta atctgctcat gacgctgcgg ctgtggtcca gctga                 825

<210> 10
<211> 347
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cloned nucleic acid sequence

<400> 10
gggtttggag ccaacagaag gaggtggagc agaattctgg acccctcagt gttccagagg 60
gagccattgc ctctctcaac tgcacttaca gtgaccgagg ttcccagtcc ttcttctggt 120
acagacaata ttctgggaaa agccctgagt tgataatgtt catatactcc aatggtgaca 180
aagaagatgg aaggtttaca gcacagctca ataaagccag ccagtatgtt tctctgctca 240
tcagagactc ccagcccagt gattcagcca cctacctctg tgccgtgaac ataggctttg 300
ggaatgtgct gcattgcggg tccggcactc aagtgattgt tttacca               347

<210> 11
<211> 274
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein expressed from cloned nucleic acid
      sequence

<400> 11
Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu
 1               5                  10                  15      
Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro
            20                  25                  30          
Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser
        35                  40                  45              
Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys
    50                  55                  60                  
Ser Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp
65                  70                  75                  80  
Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu
                85                  90                  95      
Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala
            100                 105                 110         
Val Asn Ile Gly Phe Gly Asn Val Leu His Cys Gly Ser Gly Thr Gln
        115                 120                 125             
Val Ile Val Leu Pro His Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln
    130                 135                 140                 
Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp
145                 150                 155                 160 
Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr
                165                 170                 175     
Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser
            180                 185                 190         
Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn
        195                 200                 205             
Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro
    210                 215                 220                 
Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp
225                 230                 235                 240 
Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu
                245                 250                 255     
Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp
            260                 265                 270         
Ser Ser
        


<210> 12
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein expressed from cloned nucleic acid
      sequence

<400> 12
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
 1               5                  10                  15      
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
            20                  25                  30          
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
        35                  40                  45              
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
    50                  55                  60                  
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
65                  70                  75                  80  
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
                85                  90                  95      
Asn Ile Gly Phe Gly Asn Val Leu His Cys Gly Ser Gly Thr Gln Val
            100                 105                 110         
Ile Val Leu Pro
        115     


<210> 13
<211> 930
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cloned nucleic acid sequence

<400> 13
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa 60
gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg 120
acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg 180
ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct 240
gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc 300
agccccaacc agacctctct gtacttctgt gccagcagcc tagaggtggt aggcaatgag 360
cagttcttcg ggccagggac acggctcacc gtgctagagg acctgaaaaa cgtgttccca 420
cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca 480
ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat 540
gggaaggagg tgcacagtgg ggtcagcaca gacccgcagc ccctcaagga gcagcccgcc 600
ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag 660
aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag 720
tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga 780
gcagactgtg gctttacctc ggtgtcctac cagcaagggg tcctgtctgc caccatcctc 840
tatgagatcc tgctagggaa ggccaccctg tatgctgtgc tggtcagcgc ccttgtgttg 900
atggccatgg tcaagagaaa ggatttctga                                  930

<210> 14
<211> 347
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cloned nucleic acid sequence

<400> 14
gccccctgga agcccaagtg acccagaacc caagatacct catcacagtg actggaaaga 60
agttaacagt gacttgttct cagaatatga accatgagta tatgtcctgg tatcgacaag 120
acccagggct gggcttaagg cagatctact attcaatgaa tgttgaggtg actgataagg 180
gagatgttcc tgaagggtac aaagtctctc gaaaagagaa gaggaatttc cccctgatcc 240
tggagtcgcc cagccccaac cagacctctc tgtacttctg tgccagcagc ctagaggtgg 300
taggcaatga gcagttcttc gggccaggga cacggctcac cgtgcta               347

<210> 15
<211> 309
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein expressed from cloned nucleic acid
      sequence

<400> 15
Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala
 1               5                  10                  15      
Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr
            20                  25                  30          
Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His
        35                  40                  45              
Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln
    50                  55                  60                  
Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro
65                  70                  75                  80  
Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile
                85                  90                  95      
Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser
            100                 105                 110         
Ser Leu Glu Val Val Gly Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg
        115                 120                 125             
Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
    130                 135                 140                 
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
145                 150                 155                 160 
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
                165                 170                 175     
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro
            180                 185                 190         
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
        195                 200                 205             
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
    210                 215                 220                 
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
225                 230                 235                 240 
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
                245                 250                 255     
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln
            260                 265                 270         
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
        275                 280                 285             
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
    290                 295                 300                 
Lys Arg Lys Asp Phe
305                 


<210> 16
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein expressed from cloned nucleic acid
      sequence

<400> 16
Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr
 1               5                  10                  15      
Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His
            20                  25                  30          
Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln
        35                  40                  45              
Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro
    50                  55                  60                  
Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile
65                  70                  75                  80  
Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser
                85                  90                  95      
Ser Leu Glu Val Val Gly Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg
            100                 105                 110         
Leu Thr Val Leu
        115     


<210> 17
<211> 12264
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cloned nucleic acid sequence

<400> 17
ttgtacaaag tggtgataac ctcgagggcg cgccgaattc gatatcaagc ttatcgataa 60
tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc 120
ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat 180
ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg 240
gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg 300
ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat 360
tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt 420
gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc 480
ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa 540
tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg 600
ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcatc gataccgtcg 660
acctcgagac ctagaaaaac atggagcaat cacaagtagc aatacagcag ctaccaatgc 720
tgattgtgcc tggctagaag cacaagagga ggaggaggtg ggttttccag tcacacctca 780
ggtaccttta agaccaatga cttacaaggc agctgtagat cttagccact ttttaaaaga 840
aaagggggga ctggaagggc taattcactc ccaacgaaga caagatatcc ttgatctgtg 900
gatctaccac acacaaggct acttccctga ttggcagaac tacacaccag ggccagggat 960
cagatatcca ctgacctttg gatggtgcta caagctagta ccagttgagc aagagaaggt 1020
agaagaagcc aatgaaggag agaacacccg cttgttacac cctgtgagcc tgcatgggat 1080
ggatgacccg gagagagaag tattagagtg gaggtttgac agccgcctag catttcatca 1140
catggcccga gagctgcatc cggactgtac tgggtctctc tggttagacc agatctgagc 1200
ctgggagctc tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg 1260
agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag 1320
acccttttag tcagtgtgga aaatctctag cagggcccgt ttaaacccgc tgatcagcct 1380
cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga 1440
ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt 1500
gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg 1560
attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggct tctgaggcgg 1620
aaagaaccag ctggggctct agggggtatc cccacgcgcc ctgtagcggc gcattaagcg 1680
cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg 1740
ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc 1800
taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa 1860
aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc 1920
ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac 1980
tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt 2040
ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg 2100
tcagttaggg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca 2160
tctcaattag tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat 2220
gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc 2280
gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat 2340
ttatgcagag gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt 2400
ttttggaggc ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc 2460
tgatcagcac gtgttgacaa ttaatcatcg gcatagtata tcggcatagt ataatacgac 2520
aaggtgagga actaaaccat ggccaagttg accagtgccg ttccggtgct caccgcgcgc 2580
gacgtcgccg gagcggtcga gttctggacc gaccggctcg ggttctcccg ggacttcgtg 2640
gaggacgact tcgccggtgt ggtccgggac gacgtgaccc tgttcatcag cgcggtccag 2700
gaccaggtgg tgccggacaa caccctggcc tgggtgtggg tgcgcggcct ggacgagctg 2760
tacgccgagt ggtcggaggt cgtgtccacg aacttccggg acgcctccgg gccggccatg 2820
accgagatcg gcgagcagcc gtgggggcgg gagttcgccc tgcgcgaccc ggccggcaac 2880
tgcgtgcact tcgtggccga ggagcaggac tgacacgtgc tacgagattt cgattccacc 2940
gccgccttct atgaaaggtt gggcttcgga atcgttttcc gggacgccgg ctggatgatc 3000
ctccagcgcg gggatctcat gctggagttc ttcgcccacc ccaacttgtt tattgcagct 3060
tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca 3120
ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctgtataccg 3180
tcgacctcta gctagagctt ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt 3240
tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt 3300
gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg 3360
ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg 3420
cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg 3480
cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat 3540
aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc 3600
gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc 3660
tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga 3720
agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt 3780
ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg 3840
taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc 3900
gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg 3960
gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc 4020
ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg 4080
ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc 4140
gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct 4200
caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt 4260
taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa 4320
aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa 4380
tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc 4440
tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct 4500
gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca 4560
gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt 4620
aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt 4680
gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc 4740
ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc 4800
tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt 4860
atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact 4920
ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc 4980
ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt 5040
ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg 5100
atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct 5160
gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa 5220
tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt 5280
ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc 5340
acatttcccc gaaaagtgcc acctgacgtc gacggatcgg gagatctccc gatcccctat 5400
ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagtat ctgctccctg 5460
cttgtgtgtt ggaggtcgct gagtagtgcg cgagcaaaat ttaagctaca acaaggcaag 5520
gcttgaccga caattgcatg aagaatctgc ttagggttag gcgttttgcg ctgcttcgcg 5580
atgtacgggc cagatatacg cgttgacatt gattattgac tagttattaa tagtaatcaa 5640
ttacggggtc attagttcat agcccatata tggagttccg cgttacataa cttacggtaa 5700
atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg 5760
ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt 5820
aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg 5880
tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc 5940
ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg cggttttggc 6000
agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt ctccacccca 6060
ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca aaatgtcgta 6120
acaactccgc cccattgacg caaatgggcg gtaggcgtgt acggtgggag gtctatataa 6180
gcagcgcgtt ttgcctgtac tgggtctctc tggttagacc agatctgagc ctgggagctc 6240
tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa 6300
gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag 6360
tcagtgtgga aaatctctag cagtggcgcc cgaacaggga cttgaaagcg aaagggaaac 6420
cagaggagct ctctcgacgc aggactcggc ttgctgaagc gcgcacggca agaggcgagg 6480
ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg aggctagaag gagagagatg 6540
ggtgcgagag cgtcagtatt aagcggggga gaattagatc gcgatgggaa aaaattcggt 6600
taaggccagg gggaaagaaa aaatataaat taaaacatat agtatgggca agcagggagc 6660
tagaacgatt cgcagttaat cctggcctgt tagaaacatc agaaggctgt agacaaatac 6720
tgggacagct acaaccatcc cttcagacag gatcagaaga acttagatca ttatataata 6780
cagtagcaac cctctattgt gtgcatcaaa ggatagagat aaaagacacc aaggaagctt 6840
tagacaagat agaggaagag caaaacaaaa gtaagaccac cgcacagcaa gcggccgctg 6900
atcttcagac ctggaggagg agatatgagg gacaattgga gaagtgaatt atataaatat 6960
aaagtagtaa aaattgaacc attaggagta gcacccacca aggcaaagag aagagtggtg 7020
cagagagaaa aaagagcagt gggaatagga gctttgttcc ttgggttctt gggagcagca 7080
ggaagcacta tgggcgcagc gtcaatgacg ctgacggtac aggccagaca attattgtct 7140
ggtatagtgc agcagcagaa caatttgctg agggctattg aggcgcaaca gcatctgttg 7200
caactcacag tctggggcat caagcagctc caggcaagaa tcctggctgt ggaaagatac 7260
ctaaaggatc aacagctcct ggggatttgg ggttgctctg gaaaactcat ttgcaccact 7320
gctgtgcctt ggaatgctag ttggagtaat aaatctctgg aacagatttg gaatcacacg 7380
acctggatgg agtgggacag agaaattaac aattacacaa gcttaataca ctccttaatt 7440
gaagaatcgc aaaaccagca agaaaagaat gaacaagaat tattggaatt agataaatgg 7500
gcaagtttgt ggaattggtt taacataaca aattggctgt ggtatataaa attattcata 7560
atgatagtag gaggcttggt aggtttaaga atagtttttg ctgtactttc tatagtgaat 7620
agagttaggc agggatattc accattatcg tttcagaccc acctcccaac cccgagggga 7680
cccgacaggc ccgaaggaat agaagaagaa ggtggagaga gagacagaga cagatccatt 7740
cgattagtga acggatcggc actgcgtgcg ccaattctgc agacaaatgg cagtattcat 7800
ccacaatttt aaaagaaaag gggggattgg ggggtacagt gcaggggaaa gaatagtaga 7860
cataatagca acagacatac aaactaaaga attacaaaaa caaattacaa aaattcaaaa 7920
ttttcgggtt tattacaggg acagcagaga tccagtttgg ttaattaagg gtgcagcggc 7980
ctccgcgccg ggttttggcg cctcccgcgg gcgcccccct cctcacggcg agcgctgcca 8040
cgtcagacga agggcgcagg agcgttcctg atccttccgc ccggacgctc aggacagcgg 8100
cccgctgctc ataagactcg gccttagaac cccagtatca gcagaaggac attttaggac 8160
gggacttggg tgactctagg gcactggttt tctttccaga gagcggaaca ggcgaggaaa 8220
agtagtccct tctcggcgat tctgcggagg gatctccgtg gggcggtgaa cgccgatgat 8280
tatataagga cgcgccgggt gtggcacagc tagttccgtc gcagccggga tttgggtcgc 8340
ggttcttgtt tgtggatcgc tgtgatcgtc acttggtgag ttgcgggctg ctgggctggc 8400
cggggctttc gtggccgccg ggccgctcgg tgggacggaa gcgtgtggag agaccgccaa 8460
gggctgtagt ctgggtccgc gagcaaggtt gccctgaact gggggttggg gggagcgcac 8520
aaaatggcgg ctgttcccga gtcttgaatg gaagacgctt gtaaggcggg ctgtgaggtc 8580
gttgaaacaa ggtggggggc atggtgggcg gcaagaaccc aaggtcttga ggccttcgct 8640
aatgcgggaa agctcttatt cgggtgagat gggctggggc accatctggg gaccctgacg 8700
tgaagtttgt cactgactgg agaactcggg tttgtcgtct ggttgcgggg gcggcagtta 8760
tgcggtgccg ttgggcagtg cacccgtacc tttgggagcg cgcgcctcgt cgtgtcgtga 8820
cgtcacccgt tctgttggct tataatgcag ggtggggcca cctgccggta ggtgtgcggt 8880
aggcttttct ccgtcgcagg acgcagggtt cgggcctagg gtaggctctc ctgaatcgac 8940
aggcgccgga cctctggtga ggggagggat aagtgaggcg tcagtttctt tggtcggttt 9000
tatgtaccta tcttcttaag tagctgaagc tccggttttg aactatgcgc tcggggttgg 9060
cgagtgtgtt ttgtgaagtt ttttaggcac cttttgaaat gtaatcattt gggtcaatat 9120
gtaattttca gtgttagact agtaaagctt ctgcaggtcg actctagaaa attgtccgct 9180
aaattctggc cgtttttggc ttttttgtta gacaggatcc gttatcacaa gtttgtacaa 9240
aaaagcaggc tctttaaagg aaccaattca gtcgactgga tccggtaccg aattcgcggc 9300
cgcactcgag atgatgaaat ccttgagagt tttactggtg atcctgtggc ttcagttaag 9360
ctgggtttgg agccaacaga aggaggtgga gcaggatcct ggaccactca gtgttccaga 9420
gggagccatt gtttctctca actgcactta cagcaacagt gcttttcaat acttcatgtg 9480
gtacagacag tattccagaa aaggccctga gttgctgatg tacacatact ccagtggtaa 9540
caaagaagat ggaaggttta cagcacaggt cgataaatcc agcaagtata tctccttgtt 9600
catcagagac tcacagccca gtgattcagc cacctacctc tgtgcaatga gcgagactgg 9660
aggcttcaaa actatctttg gagcaggaac aagactattt gttaaagcaa atatccagaa 9720
ccctgaccct gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct 9780
attcaccgat tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat 9840
cacagacaaa actgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc 9900
ctggagcaac aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga 9960
agacaccttc ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt 10020
tgaaacagat acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct 10080
cctgaaagtg gccgggttta atctgctcat gacgctgcgg ctgtggtcca gccgggctaa 10140
gagaggttct ggagcaccgg tgaaacagac tttgaatttt gaccttctca agttggcggg 10200
agacgtggag tccaacccag ggcccatggg cccccagctc cttggctatg tggtcctttg 10260
ccttctagga gcaggccccc tggaagccca agtgacccag aacccaagat acctcatcac 10320
agtgactgga aagaagttaa cagtgacttg ttctcagaat atgaaccatg agtatatgtc 10380
ctggtatcga caagacccag ggctgggctt aaggcagatc tactattcaa tgaatgttga 10440
ggtgactgat aagggagatg ttcctgaagg gtacaaagtc tctcgaaaag agaagaggaa 10500
tttccccctg atcctggagt cgcccagccc caaccagacc tctctgtact tctgtgccag 10560
cagtttagta gggacagcgg ggtcacccct ccactttggg aacgggacca ggctcactgt 10620
gacagaggac ctgaacaagg tgttcccacc cgaggtcgct gtgtttgagc catcagaagc 10680
agagatctcc cacacccaaa aggccacact ggtgtgcctg gccacaggct tcttccctga 10740
ccacgtggag ctgagctggt gggtgaatgg gaaggaggtg cacagtgggg tcagcacgga 10800
cccgcagccc ctcaaggagc agcccgccct caatgactcc agatactgcc tgagcagccg 10860
cctgagggtc tcggccacct tctggcagaa cccccgcaac cacttccgct gtcaagtcca 10920
gttctacggg ctctcggaga atgacgagtg gacccaggat agggccaaac ccgtcaccca 10980
gatcgtcagc gccgaggcct ggggtagagc agactgtggc tttacctcgg tgtcctacca 11040
gcaaggggtc ctgtctgcca ccatcctcta tgagatcctg ctagggaagg ccaccctgta 11100
tgctgtgctg gtcagcgccc ttgtgttgat ggccatggtc aagagaaagg atttccgagc 11160
aaagagatcc ggaagcggag ccactaactt ctccctgttg aaacaagcag gggatgtcga 11220
agagaatccc gggccaatgc ccacgctact gcgggtttat atagacggtc cccacgggat 11280
ggggaaaacc accaccacgc aactgctggt ggccctgggt tcgcgcgacg atatcgtcta 11340
cgtacccgag ccgatgactt actggcgggt gctgggggct tccgagacaa tcgcgaacat 11400
ctacaccaca caacaccgcc tcgaccaggg tgagatatcg gccggggacg cggcggtggt 11460
aatgacaagc gcccagataa caatgggcat gccttatgcc gtgaccgacg ccgttctggc 11520
tcctcatatc gggggggagg ctgggagctc acatgccccg cccccggccc tcaccatctt 11580
cctcgaccgc catcccatcg ccttcatgct gtgctacccg gccgcgcggt accttatggg 11640
cagcatgacc ccccaggccg tgctggcgtt cgtggccctc atcccgccga ccttgcccgg 11700
caccaacatc gtgcttgggg cccttccgga ggacagacac atcgaccgcc tggccaaacg 11760
ccagcgcccc ggcgagcggc tggacctggc tatgctggct gcgattcgcc gcgtttacgg 11820
gctacttgcc aatacggtgc ggtatctgca gtgcggcggg tcgtggcggg aggactgggg 11880
acagctttcg gggacggccg tgccgcccca gggtgccgag ccccagagca acgcgggccc 11940
acgaccccat atcggggaca cgttatttac cctgtttcgg gcccccgagt tgctggcccc 12000
caacggcgac ctgtataacg tgtttgcctg ggccttggac gtcttggcca aacgcctccg 12060
ttccatgcac gtctttatcc tggattacga ccaatcgccc gccggctgcc gggacgccct 12120
gctgcaactt acctccggga tggtccagac ccacgtcacc acccccggct ccataccgac 12180
gatatgcgac ctggcgcgca cgtttgcccg ggagatgggg gaggctaact gagcggccgc 12240
tcgagatatc tagacccagc tttc                                        12264



<210> 18
<211> 993
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cloned nucleic acid sequence

<400> 18
atgcccacgc tactgcgggt ttatatagac ggtccccacg ggatggggaa aaccaccacc 60
acgcaactgc tggtggccct gggttcgcgc gacgatatcg tctacgtacc cgagccgatg 120
acttactggc gggtgctggg ggcttccgag acaatcgcga acatctacac cacacaacac 180
cgcctcgacc agggtgagat atcggccggg gacgcggcgg tggtaatgac aagcgcccag 240
ataacaatgg gcatgcctta tgccgtgacc gacgccgttc tggctcctca tatcgggggg 300
gaggctggga gctcacatgc cccgcccccg gccctcacca tcttcctcga ccgccatccc 360
atcgccttca tgctgtgcta cccggccgcg cggtacctta tgggcagcat gaccccccag 420
gccgtgctgg cgttcgtggc cctcatcccg ccgaccttgc ccggcaccaa catcgtgctt 480
ggggcccttc cggaggacag acacatcgac cgcctggcca aacgccagcg ccccggcgag 540
cggctggacc tggctatgct ggctgcgatt cgccgcgttt acgggctact tgccaatacg 600
gtgcggtatc tgcagtgcgg cgggtcgtgg cgggaggact ggggacagct ttcggggacg 660
gccgtgccgc cccagggtgc cgagccccag agcaacgcgg gcccacgacc ccatatcggg 720
gacacgttat ttaccctgtt tcgggccccc gagttgctgg cccccaacgg cgacctgtat 780
aacgtgtttg cctgggcctt ggacgtcttg gccaaacgcc tccgttccat gcacgtcttt 840
atcctggatt acgaccaatc gcccgccggc tgccgggacg ccctgctgca acttacctcc 900
gggatggtcc agacccacgt caccaccccc ggctccatac cgacgatatg cgacctggcg 960
cgcacgtttg cccgggagat gggggaggct aac                              993

<210> 19
<211> 118
<212> PRT
<213> Homo sapiens

<400> 19
Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly
 1               5                  10                  15      
His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile
            20                  25                  30          
Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys
        35                  40                  45              
Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val
    50                  55                  60                  
Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp
65                  70                  75                  80  
His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val
                85                  90                  95      
Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser
            100                 105                 110         
Pro Pro Pro Tyr Ser Pro
        115             


<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 20
Glu Ala Ala Gly Ile Gly Ile Leu Thr Val
 1               5                  10  


<210> 21
<211> 9941
<212> DNA
<213> Artificial Sequence

<220> 
<223> Constructed plasmid vector

<400> 21
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg 60
atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt 120
gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc 180
tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac 240
attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat 300
atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg 360
acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt 420
tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag 480
tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc 540
attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag 600
tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt 660
ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc 720
accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg 780
gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct 840
ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt 900
aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac 960
tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc 1020
gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc 1080
ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa 1140
ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg 1200
ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata 1260
aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc 1320
tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga 1380
caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc 1440
aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca 1500
aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg 1560
agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga 1620
gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata 1680
ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg 1740
acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg 1800
ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag 1860
ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt 1920
tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt 1980
aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt 2040
aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag 2100
aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata 2160
acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta 2220
agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta 2280
tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa 2340
gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt 2400
gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat 2460
tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa 2520
agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag 2580
agatccagtt tggttaatta agggtgcagc ggcctccgcg ccgggttttg gcgcctcccg 2640
cgggcgcccc cctcctcacg gcgagcgctg ccacgtcaga cgaagggcgc aggagcgttc 2700
ctgatccttc cgcccggacg ctcaggacag cggcccgctg ctcataagac tcggccttag 2760
aaccccagta tcagcagaag gacattttag gacgggactt gggtgactct agggcactgg 2820
ttttctttcc agagagcgga acaggcgagg aaaagtagtc ccttctcggc gattctgcgg 2880
agggatctcc gtggggcggt gaacgccgat gattatataa ggacgcgccg ggtgtggcac 2940
agctagttcc gtcgcagccg ggatttgggt cgcggttctt gtttgtggat cgctgtgatc 3000
gtcacttggt gagttgcggg ctgctgggct ggccggggct ttcgtggccg ccgggccgct 3060
cggtgggacg gaagcgtgtg gagagaccgc caagggctgt agtctgggtc cgcgagcaag 3120
gttgccctga actgggggtt ggggggagcg cacaaaatgg cggctgttcc cgagtcttga 3180
atggaagacg cttgtaaggc gggctgtgag gtcgttgaaa caaggtgggg ggcatggtgg 3240
gcggcaagaa cccaaggtct tgaggccttc gctaatgcgg gaaagctctt attcgggtga 3300
gatgggctgg ggcaccatct ggggaccctg acgtgaagtt tgtcactgac tggagaactc 3360
gggtttgtcg tctggttgcg ggggcggcag ttatgcggtg ccgttgggca gtgcacccgt 3420
acctttggga gcgcgcgcct cgtcgtgtcg tgacgtcacc cgttctgttg gcttataatg 3480
cagggtgggg ccacctgccg gtaggtgtgc ggtaggcttt tctccgtcgc aggacgcagg 3540
gttcgggcct agggtaggct ctcctgaatc gacaggcgcc ggacctctgg tgaggggagg 3600
gataagtgag gcgtcagttt ctttggtcgg ttttatgtac ctatcttctt aagtagctga 3660
agctccggtt ttgaactatg cgctcggggt tggcgagtgt gttttgtgaa gttttttagg 3720
caccttttga aatgtaatca tttgggtcaa tatgtaattt tcagtgttag actagtaaag 3780
cttctgcagg tcgactctag aaaattgtcc gctaaattct ggccgttttt ggcttttttg 3840
ttagacagga tccccgggta ccggtcgcca ccatggtgag caagggcgag gagctgttca 3900
ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg 3960
tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca 4020
ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc 4080
agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc 4140
ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc 4200
gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg 4260
acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca 4320
acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc 4380
acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg 4440
gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc gccctgagca 4500
aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga 4560
tcactctcgg catggacgag ctgtacaagt aaagcggccg cgactctaga attcgatatc 4620
aagcttatcg ataatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt 4680
aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct 4740
attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt 4800
tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac 4860
gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct 4920
ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca 4980
ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaaatc atcgtccttt 5040
ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc 5100
ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct 5160
cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg 5220
catcgatacc gtcgacctcg agacctagaa aaacatggag caatcacaag tagcaataca 5280
gcagctacca atgctgattg tgcctggcta gaagcacaag aggaggagga ggtgggtttt 5340
ccagtcacac ctcaggtacc tttaagacca atgacttaca aggcagctgt agatcttagc 5400
cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg aagacaagat 5460
atccttgatc tgtggatcta ccacacacaa ggctacttcc ctgattggca gaactacaca 5520
ccagggccag ggatcagata tccactgacc tttggatggt gctacaagct agtaccagtt 5580
gagcaagaga aggtagaaga agccaatgaa ggagagaaca cccgcttgtt acaccctgtg 5640
agcctgcatg ggatggatga cccggagaga gaagtattag agtggaggtt tgacagccgc 5700
ctagcatttc atcacatggc ccgagagctg catccggact gtactgggtc tctctggtta 5760
gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa 5820
taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac 5880
tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagggc ccgtttaaac 5940
ccgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc 6000
cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga 6060
aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga 6120
cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat 6180
ggcttctgag gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag 6240
cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag 6300
cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt 6360
tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca 6420
cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata 6480
gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca 6540
aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc 6600
gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt 6660
ctgtggaatg tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt 6720
atgcaaagca tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca 6780
gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta 6840
actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga 6900
ctaatttttt ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag 6960
tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agctcccggg agcttgtata 7020
tccattttcg gatctgatca gcacgtgttg acaattaatc atcggcatag tatatcggca 7080
tagtataata cgacaaggtg aggaactaaa ccatggccaa gttgaccagt gccgttccgg 7140
tgctcaccgc gcgcgacgtc gccggagcgg tcgagttctg gaccgaccgg ctcgggttct 7200
cccgggactt cgtggaggac gacttcgccg gtgtggtccg ggacgacgtg accctgttca 7260
tcagcgcggt ccaggaccag gtggtgccgg acaacaccct ggcctgggtg tgggtgcgcg 7320
gcctggacga gctgtacgcc gagtggtcgg aggtcgtgtc cacgaacttc cgggacgcct 7380
ccgggccggc catgaccgag atcggcgagc agccgtgggg gcgggagttc gccctgcgcg 7440
acccggccgg caactgcgtg cacttcgtgg ccgaggagca ggactgacac gtgctacgag 7500
atttcgattc caccgccgcc ttctatgaaa ggttgggctt cggaatcgtt ttccgggacg 7560
ccggctggat gatcctccag cgcggggatc tcatgctgga gttcttcgcc caccccaact 7620
tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata 7680
aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc 7740
atgtctgtat accgtcgacc tctagctaga gcttggcgta atcatggtca tagctgtttc 7800
ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt 7860
gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc 7920
ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg 7980
ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct 8040
cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca 8100
cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga 8160
accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc 8220
acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg 8280
cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat 8340
acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt 8400
atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc 8460
agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg 8520
acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg 8580
gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg 8640
gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg 8700
gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca 8760
gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga 8820
acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga 8880
tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt 8940
ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt 9000
catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat 9060
ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag 9120
caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct 9180
ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt 9240
tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg 9300
cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca 9360
aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt 9420
tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat 9480
gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac 9540
cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa 9600
aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt 9660
tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt 9720
tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa 9780
gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt 9840
atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa 9900
taggggttcc gcgcacattt ccccgaaaag tgccacctga c                     9941


