                         SEQUENCE LISTING

<110>  DSM IP Assets B.V.
 
<120>  Production of beta-lactam antibiotics

<130>  25649WO

<160>  37    

<170>  PatentIn version 3.3

<210>  1
<211>  331
<212>  PRT
<213>  Emericella nidulans

<400>  1

Met Gly Ser Val Ser Lys Ala Asn Val Pro Lys Ile Asp Val Ser Pro 
1               5                   10                  15      


Leu Phe Gly Asp Asp Gln Ala Ala Lys Met Arg Val Ala Gln Gln Ile 
            20                  25                  30          


Asp Ala Ala Ser Arg Asp Thr Gly Phe Phe Tyr Ala Val Asn His Gly 
        35                  40                  45              


Ile Asn Val Gln Arg Leu Ser Gln Lys Thr Lys Glu Phe His Met Ser 
    50                  55                  60                  


Ile Thr Pro Glu Glu Lys Trp Asp Leu Ala Ile Arg Ala Tyr Asn Lys 
65                  70                  75                  80  


Glu His Gln Asp Gln Val Arg Ala Gly Tyr Tyr Leu Ser Ile Pro Gly 
                85                  90                  95      


Lys Lys Ala Val Glu Ser Phe Cys Tyr Leu Asn Pro Asn Phe Thr Pro 
            100                 105                 110         


Asp His Pro Arg Ile Gln Ala Lys Thr Pro Thr His Glu Val Asn Val 
        115                 120                 125             


Trp Pro Asp Glu Thr Lys His Pro Gly Phe Gln Asp Phe Ala Glu Gln 
    130                 135                 140                 


Tyr Tyr Trp Asp Val Phe Gly Leu Ser Ser Ala Leu Leu Lys Gly Tyr 
145                 150                 155                 160 


Ala Leu Ala Leu Gly Lys Glu Glu Asn Phe Phe Ala Arg His Phe Lys 
                165                 170                 175     


Pro Asp Asp Thr Leu Ala Ser Val Val Leu Ile Arg Tyr Pro Tyr Leu 
            180                 185                 190         


Asp Pro Tyr Pro Glu Ala Ala Ile Lys Thr Ala Ala Asp Gly Thr Lys 
        195                 200                 205             


Leu Ser Phe Glu Trp His Glu Asp Val Ser Leu Ile Thr Val Leu Tyr 
    210                 215                 220                 


Gln Ser Asn Val Gln Asn Leu Gln Val Glu Thr Ala Ala Gly Tyr Gln 
225                 230                 235                 240 


Asp Ile Glu Ala Asp Asp Thr Gly Tyr Leu Ile Asn Cys Gly Ser Tyr 
                245                 250                 255     


Met Ala His Leu Thr Asn Asn Tyr Tyr Lys Ala Pro Ile His Arg Val 
            260                 265                 270         


Lys Trp Val Asn Ala Glu Arg Gln Ser Leu Pro Phe Phe Val Asn Leu 
        275                 280                 285             


Gly Tyr Asp Ser Val Ile Asp Pro Phe Asp Pro Arg Glu Pro Asn Gly 
    290                 295                 300                 


Lys Ser Asp Arg Glu Pro Leu Ser Tyr Gly Asp Tyr Leu Gln Asn Gly 
305                 310                 315                 320 


Leu Val Ser Leu Ile Asn Lys Asn Gly Gln Thr 
                325                 330     


<210>  2
<211>  1106
<212>  PRT
<213>  Streptomyces coelicolor

<400>  2

Met Ala Thr Leu Pro Glu Leu Phe Ala Glu Gln Ala Leu Arg Thr Pro 
1               5                   10                  15      


Gly Ala Pro Ala Leu Val Arg Gly Gly Thr Thr Val Ser Tyr Ala Glu 
            20                  25                  30          


Leu Asp Leu Arg Thr Asn Arg Leu Ala Arg Leu Leu Arg Gln Gln Gly 
        35                  40                  45              


Val Arg Pro Gly Thr Pro Val Val Met Leu Met Glu Arg Ser Pro Ala 
    50                  55                  60                  


His Val Val Ala Thr Leu Ala Ile Ala Lys Ala Gly Gly Ala Tyr Val 
65                  70                  75                  80  


Pro Leu His Asp Thr Tyr Pro Leu Asp Arg Met Arg His Val Val Ala 
                85                  90                  95      


Asp Thr Ala Ala Thr Leu Ile Leu Thr Asp Arg Ala Glu Ala Ala Arg 
            100                 105                 110         


Ala Gly Gln Leu Gly Ala Arg Val Met Val Val Asp Glu Phe Gly Ala 
        115                 120                 125             


Ala Pro Ser Gly Ser Glu Ala Asp Ala Ala Pro Gly Thr Gly Thr Gly 
    130                 135                 140                 


Thr Gly Thr Gly Ser Arg Ser Gly Tyr Val Asp Asp Ala Pro Glu Val 
145                 150                 155                 160 


Gly Leu Arg Pro Gln Asp Leu Ala Tyr Val Met Tyr Thr Ser Gly Ser 
                165                 170                 175     


Thr Gly Val Pro Lys Gly Val Ala Val Thr His Arg Gly Val Val Asp 
            180                 185                 190         


Leu Val Arg Asp His Cys Trp Arg Pro Gly Val His Glu Arg Val Leu 
        195                 200                 205             


Leu His Ala Pro His Ala Phe Asp Val Ser Cys Tyr Glu Met Trp Val 
    210                 215                 220                 


Pro Leu Val Ser Gly Gly Thr Val Val Val Ala Pro Pro Gly His Leu 
225                 230                 235                 240 


Asp Pro Ala Ala Ile Thr Asp Leu Ile Thr Ala His Asp Ile Thr Ala 
                245                 250                 255     


Ile His Leu Thr Ala Gly Phe Phe Arg Val Val Ala Glu Glu Ala Pro 
            260                 265                 270         


Glu Cys Phe Ala Gly Val Arg Glu Val Leu Thr Gly Gly Asp Val Val 
        275                 280                 285             


Ser Pro Ala Ala Val Ala Arg Val Leu Ala His His Pro Arg Ile Val 
    290                 295                 300                 


Leu Arg His Leu Tyr Gly Pro Thr Glu Thr Thr Leu Cys Val Thr Gln 
305                 310                 315                 320 


His Glu Val Thr Ala Pro Tyr Glu Ala Arg Gly Ser Leu Pro Val Gly 
                325                 330                 335     


Arg Ala Thr Gly Asn Thr Arg Ala Tyr Val Leu Asp Arg Tyr Leu Gln 
            340                 345                 350         


Pro Val Pro Ala Gly Val Pro Gly Glu Leu Phe Ile Ser Gly Ser Gly 
        355                 360                 365             


Leu Ala Arg Gly Tyr Leu Asp Arg Pro Asp Leu Thr Cys Glu Arg Phe 
    370                 375                 380                 


Val Ala Asp Pro Tyr Gly Gly Ser Gly Glu Arg Met Tyr Arg Thr Gly 
385                 390                 395                 400 


Asp Leu Val Arg Tyr Asn Ala Ala Gly Glu Leu Glu Tyr Leu Ala Arg 
                405                 410                 415     


Ala Asp Asp Gln Val Lys Ile Arg Gly Phe Arg Val Glu Leu Gly Glu 
            420                 425                 430         


Ile Glu Ala Val Leu Ala Thr Arg Pro Glu Leu Ala Gln Ala Ala Val 
        435                 440                 445             


Val Val Arg Glu Asp Arg Pro Gly Asp Arg Arg Leu Val Gly Tyr Val 
    450                 455                 460                 


Val Ala Ala Ala Gly Arg Asp Gly Glu Val Asp Pro Asp Ala Leu Arg 
465                 470                 475                 480 


Ala Phe Ser Arg Gln Ala Leu Pro Asp Tyr Met Val Pro Ser Ala Phe 
                485                 490                 495     


Val Val Leu Gly Thr Leu Pro Leu Thr Ala Asn Gly Lys Leu Asp Arg 
            500                 505                 510         


Lys Ala Leu Pro Ala Pro Asp Tyr Gly Ala Ala Ser Thr Gly Arg Ala 
        515                 520                 525             


Ala Arg Thr Pro Ala Glu Glu Leu Leu Cys Thr Leu Phe Ala Gln Val 
    530                 535                 540                 


Leu Gly Leu Ser Ala Val Gly Val Asp Asp Gly Phe Phe Asp Leu Gly 
545                 550                 555                 560 


Gly Asp Ser Ile Leu Ser Ile Gln Leu Val Ser Arg Ala Arg Ala Ala 
                565                 570                 575     


Gly Leu Ala Leu Ala Val Arg Asp Val Phe Glu His Gln Ser Thr Ala 
            580                 585                 590         


Arg Leu Ala Ala Ala Leu Thr Asp Arg Asp Asp Ala Ala Ser Val Pro 
        595                 600                 605             


Glu Ala Glu Ala Val Pro Pro Tyr Gly Pro Ala Pro Leu Thr Pro Val 
    610                 615                 620                 


Met Ala Arg Ile Ala Glu Leu Gly Leu Gly Gly Asp Asp Phe Asn Gln 
625                 630                 635                 640 


Ser Val Val Val Ser Leu Pro Pro Ala Val Asp Arg Asp Arg Leu Val 
                645                 650                 655     


Pro Ala Leu Gln Arg Val Leu Asp His His Asp Ala Leu Arg Leu Arg 
            660                 665                 670         


Val Leu Pro Asp Gly Ser Thr Glu Val Arg Ala Pro Gly Ser Val Pro 
        675                 680                 685             


Ala Ala Asp Val Leu Ser Val Val Thr Arg Ala Pro Gly Ala Thr Gly 
    690                 695                 700                 


Glu Ala Arg Asp Ala Leu Leu Val Glu Ala Ala Cys Ala Ala Arg Asp 
705                 710                 715                 720 


Arg Leu Ala Pro Ala Glu Gly Arg Met Leu Gln Ala Val Leu Val Asp 
                725                 730                 735     


Gly Thr Asp Asp Thr Asp Gly Thr Gly Gly Thr Ser Gly Ala Asp Gly 
            740                 745                 750         


Val Leu Ile Leu Val Ala His His Leu Val Val Asp Ser Val Thr Trp 
        755                 760                 765             


Ser Ile Val Val Pro Asp Leu Ala Ala Ala Tyr Arg Gly Glu Glu Pro 
    770                 775                 780                 


Ala Pro Val Gly Thr Ser Trp Arg Gln Trp Ala Thr Ser Leu Ala Arg 
785                 790                 795                 800 


Leu Ala Thr Asp Pro Arg Val Glu Ala Glu Thr Ala His Trp Glu His 
                805                 810                 815     


Thr Leu Thr Gly Ala Gly Thr Leu Arg Leu Asp Arg Gly Arg Asp Leu 
            820                 825                 830         


Gln Gly Asp Ala Gly Arg Ile Ser Leu Asp Leu Ala Pro His Thr Thr 
        835                 840                 845             


Glu Ala Leu Leu Thr Arg Leu Pro Gly Gly Val Asn Ala Ser Val His 
    850                 855                 860                 


Asp Val Leu Leu Thr Ala Phe Ala Phe Ala Val Ala Gly Trp Arg Arg 
865                 870                 875                 880 


Gly Arg Gly Glu Asp Pro Asp Ala Pro Val Val Leu Asp Leu Glu Ser 
                885                 890                 895     


His Gly Arg His Glu Glu Ala Val Pro Gly Ala Glu Leu Ser Arg Thr 
            900                 905                 910         


Ala Gly Trp Phe Thr Ala Leu His Pro Val Arg Leu Ala Pro Asp Val 
        915                 920                 925             


Thr Asp Trp Ala Arg Leu His Gln Asp Gly Asp Ala Leu Arg Asp Gly 
    930                 935                 940                 


Leu Lys Gln Val Lys Glu Gln Leu Arg Ser Val Pro Gly Asp Gly Leu 
945                 950                 955                 960 


Gly His Gly Leu Leu Arg His Leu Asn Pro Thr Ala Gly Pro Arg Leu 
                965                 970                 975     


Ala Arg Leu Pro Glu Pro Asp Phe Gly Phe Asn Tyr Leu Gly Arg Arg 
            980                 985                 990         


Val Thr Pro Ala Thr Gly Thr Pro  Glu Pro Trp Thr Val  Thr Gly Gly 
        995                 1000                 1005             


Gly Leu  Ala Ala Ser Arg Pro  Thr Ala Pro Met Ala  His Ala Val 
    1010                 1015                 1020             


Glu Leu  Ser Ala Val Val His  Glu Gly Ala Asp Gly  Pro Arg Leu 
    1025                 1030                 1035             


Arg Ala  Glu Trp Thr Tyr Ala  Arg Arg Leu Val Pro  Asp His Asp 
    1040                 1045                 1050             


Ala Arg  Arg Leu Ala Glu Gln  Trp Phe Arg Ala Leu  Glu Ala Leu 
    1055                 1060                 1065             


Val Glu  Gln Ala Asp Arg Ala  Gly Thr Gly Gly Leu  Thr Pro Ser 
    1070                 1075                 1080             


Asp Val  Thr Leu Gly Ser Leu  Ser Gln Ser Glu Ile  Glu Glu Phe 
    1085                 1090                 1095             


Glu Ser  Asp Leu Glu Ser Glu  Trp 
    1100                 1105     


<210>  3
<211>  3318
<212>  DNA
<213>  Streptomyces coelicolor

<400>  3
atggcgacgc tgccggaact gttcgcggag caggcgctcc ggacgcccgg ggcaccggcg     60

ctggtgcggg gcgggacgac ggtgtcgtac gccgaactcg acctgcgcac caaccggctg    120

gcccggctgc tgcggcagca gggggtgcgg ccgggcacgc cggtggtcat gctgatggag    180

cggtcgcccg cccatgtcgt ggcgacgctg gccatcgcca aggcgggcgg cgcctacgtg    240

cccctgcacg acacgtatcc cctcgaccgg atgcggcacg tggtggcgga caccgccgcg    300

acgctgatcc tcaccgaccg ggccgaggcg gcgcgggccg ggcagctcgg cgcgcgggtg    360

atggtggtcg acgagttcgg cgccgccccg tccggctcgg aggccgacgc ggcccccggc    420

accggcaccg gcaccggcac cggctcgcgc tccgggtacg tcgacgatgc tccggaggtg    480

ggcctgcgcc cgcaggatct cgcgtacgtg atgtacacct ccgggtccac cggggtgccg    540

aagggcgtcg cggtcaccca ccgcggggtc gtggacctgg tccgcgacca ctgctggcgg    600

ccgggcgtcc acgagcgggt gctgctgcac gccccgcacg cgttcgacgt gtcctgctac    660

gagatgtggg tgcccctggt ctcgggcgga acggtcgtcg tggcaccgcc cggacacctg    720

gacccggccg cgatcaccga cctgatcacc gctcacgaca tcaccgcgat ccacctcacc    780

gcgggcttct tccgggtcgt cgcggaggag gcaccggagt gcttcgccgg tgtgcgggag    840

gtgctgaccg gcggcgacgt ggtctcgcca gccgcggtgg cccgggtcct cgcgcaccac    900

ccgcggatcg tactgcgtca cctgtacggg ccgaccgaga cgacgctgtg cgtgacgcag    960

cacgaggtca ccgcgccgta cgaggcccgc ggcagcctgc cggtcgggcg ggcgacgggg   1020

aacacccggg cctacgtgct cgaccggtac ctccagccgg tgccggccgg cgtgccgggc   1080

gagctgttca tctccggctc cggtctggcg cgcggctacc tggaccgtcc cgacctgacc   1140

tgtgagcggt tcgtcgccga tccgtacggc gggtccggcg agcggatgta ccgcacgggc   1200

gacctggtcc gctacaacgc ggcgggcgaa ctggagtacc tggcccgcgc cgacgaccag   1260

gtcaagatcc gcggcttccg ggtggaactg ggcgagatcg aggcggtcct ggccacgcgc   1320

ccggagctgg cccaggccgc cgtcgtcgtc cgcgaggacc ggcccggcga ccggcgcctg   1380

gtcggctacg tggtggccgc ggcgggccgg gacggcgagg tcgacccgga cgcgctgcgc   1440

gccttctccc gccaggcgct gccggactac atggtgccgt cggcgttcgt ggtcctcggc   1500

accctgccgc tgaccgccaa cggcaaactg gaccgcaagg cgctgcccgc gcccgactac   1560

ggggcggcgt ccaccgggcg ggccgcccgc acccctgccg aggagctgct gtgcacgctc   1620

ttcgcccagg tgctcggcct gtccgcggtg ggcgtcgacg acgggttctt cgatctgggc   1680

ggcgacagca tcctgtccat ccagctcgtc agccgggccc gcgccgccgg actcgccctc   1740

gccgtccgcg acgtcttcga gcaccagtcg acggcccggc tggccgccgc gctgacggac   1800

cgggacgacg cggcctccgt gccggaggcc gaagcggtgc cgccgtacgg tcccgccccg   1860

ctgacccccg tgatggcccg catcgccgaa ctgggcctgg gcggagacga cttcaaccag   1920

tcggtcgtgg tgtccctgcc gcccgcggtg gaccgggacc ggctcgtccc ggccctgcaa   1980

cgtgtgctcg accaccatga cgcgctgcgc ctgcgcgtcc tgcccgacgg gagcacggag   2040

gtacgcgccc cgggcagtgt gccggccgcg gacgtcctga gcgtcgtcac gcgggccccc   2100

ggcgccaccg gcgaggcgcg cgacgccctg ctcgtggagg cggcgtgcgc cgcacgggac   2160

cggctcgcac cggccgaggg ccgcatgctc caggcggtcc tggtcgacgg cacggacgac   2220

acggacggca cgggcgggac ctccggggcg gacggcgtgc tgatcctggt cgcccaccac   2280

ctggtggtcg actcggtgac gtggagcatc gtcgtaccgg acctcgccgc ggcctaccgg   2340

ggcgaggagc ccgccccggt gggcacctcg tggcggcagt gggccacctc cctggcacgg   2400

ctggccaccg acccccgcgt cgaggcggag accgcccact gggagcacac gctcaccggg   2460

gcgggcaccc tgcggctgga ccgcggccgc gatctccagg gcgacgccgg acgcatcagc   2520

ctcgacctgg ccccgcacac gaccgaggcc ctgctcacgc gcctgcccgg gggcgtcaac   2580

gcgagcgtgc acgacgtcct gctgaccgcc ttcgcgttcg ccgtcgccgg gtggcggcgc   2640

ggacgcggcg aggacccgga cgcgcccgtc gtgctcgacc tggagagcca cggccggcac   2700

gaggaggcgg tgccgggcgc cgaactcagc cgcacggcgg gctggttcac ggccctccac   2760

ccggtgcggc tggctccgga cgtcaccgac tgggcgcggc tgcaccagga cggcgacgcg   2820

ctccgggacg gcctcaagca ggtgaaggaa cagttgcggt ccgtaccggg cgacggcctc   2880

ggccacggct tgctgcgcca cctcaacccc accgctgggc cccgcctcgc acgccttccc   2940

gagcccgact tcggcttcaa ctacctgggc cgccgggtca ccccggccac cggcaccccg   3000

gaaccgtgga ccgtcacggg cggcggcctc gccgcctcgc ggcccacggc gccgatggcc   3060

cacgcggtgg agctgagcgc cgtcgtccac gagggggcgg acggcccccg actgcgcgcg   3120

gagtggacct acgcacgccg cctggtcccc gatcacgacg cccgccgcct ggccgagcaa   3180

tggttccggg cgctggaagc cctggtggag caggccgacc gggccggcac cggcggcctg   3240

accccgtccg acgtgaccct cggctcgctc agccagtccg agatcgagga attcgagtcc   3300

gaccttgagt ccgagtgg                                                 3318


<210>  4
<211>  1091
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid sequence

<400>  4

Met Ala Cys Leu Pro Arg Arg Ile Ala Glu Gln Ala Ala Arg Thr Pro 
1               5                   10                  15      


His Ala Val Ala Val Thr Glu Ala Gly Gly Thr Leu Ile Thr Tyr Ser 
            20                  25                  30          


Glu Leu Asp Ala Arg Ala Asn Arg Leu Ala Arg His Leu Ile Arg Arg 
        35                  40                  45              


Gly Val Thr Ala Glu Thr Arg Val Ala Val Leu Ala Glu Arg Ser Ala 
    50                  55                  60                  


Gln Leu Val Val Thr Thr Leu Ala Ile Leu Lys Ala Gly Gly Val Tyr 
65                  70                  75                  80  


Val Pro Leu His Thr Gly Tyr Pro Val Asp Arg Met Arg His Val Leu 
                85                  90                  95      


Ala Asp Thr Glu Ala Ala Leu Leu Leu Thr Asp Thr His His Ala Ala 
            100                 105                 110         


Thr Ala Ala Arg Leu Asp Thr Pro Ala Leu Thr Val Asp Glu Asp Thr 
        115                 120                 125             


Thr Ala Gly Glu Gln Asp Thr Thr Ala Pro Asp Val Thr Val Arg Pro 
    130                 135                 140                 


Asp Gln Leu Ala Tyr Ile Met Phe Thr Ser Gly Ser Thr Gly Thr Pro 
145                 150                 155                 160 


Lys Gly Ile Gly Ile Thr His Arg Asp Ala Ile Ala Leu Ala Ala Asp 
                165                 170                 175     


Arg Cys Trp Asp Leu Asp Thr Gly Ser Arg Val Leu Met His Ser Pro 
            180                 185                 190         


Tyr Ala Phe Asp Ile Ser Thr Phe Glu Leu Phe Ala Pro Leu Leu Ala 
        195                 200                 205             


Gly Gly Arg Ile Val Val Ala Pro Arg Gly Asp Ile Asp Ala Ala Val 
    210                 215                 220                 


Leu Gln Arg Thr Leu Ala Ala His Gly Val Thr Ser Leu Leu Leu Thr 
225                 230                 235                 240 


Ala Gly Leu Leu Gly Val Ile Ala Asp Glu Ala Pro Glu Val Phe Thr 
                245                 250                 255     


Gly Val Lys Asp Val Trp Thr Gly Gly Asp Val Val Ser Pro Thr Ala 
            260                 265                 270         


Val Arg Arg Val Leu Glu Ala Cys Pro Gly Thr Val Val Lys Thr Leu 
        275                 280                 285             


Tyr Gly Pro Thr Glu Thr Thr Leu Gly Cys Thr Trp Leu Pro Phe Thr 
    290                 295                 300                 


Asp Pro Arg Arg Ile Pro Pro Ala Val Pro Ile Gly Arg Pro Leu Asp 
305                 310                 315                 320 


Asn Thr Arg Ala Tyr Val Leu Asp Glu Arg Leu Arg Pro Val Pro Pro 
                325                 330                 335     


Gly Val Thr Gly Glu Leu Tyr Ile Ala Gly Ala Gly Leu Ala Arg Gly 
            340                 345                 350         


Tyr Trp Asp Gln Ser Ala Arg Thr Ala Glu Arg Phe Thr Ala Asp Pro 
        355                 360                 365             


His Ala His Leu Phe Gly Asp Thr Gly Gly Arg Met Tyr Arg Thr Gly 
    370                 375                 380                 


Asp Leu Ala Arg Arg Asp Ala Asp Gly Val Leu His Phe Cys Gly Arg 
385                 390                 395                 400 


Ala Asp Gln Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Pro Gly Glu 
                405                 410                 415     


Ile Glu Thr Ala Leu Ala Ala His Pro Asp Val Thr Arg Ala Ala Val 
            420                 425                 430         


Val Ala Arg Pro Gly Arg Ala Gly Asp Lys Val Leu Val Ala Tyr Leu 
        435                 440                 445             


Val Thr Ala Pro Asp Ala Gly Asp Thr Thr Ala Glu Gln Leu Arg Ala 
    450                 455                 460                 


Gly Leu Glu Thr Gln Leu Pro Asp Tyr Met Val Pro Ala Ala Phe Val 
465                 470                 475                 480 


Ala Leu Pro Ala Leu Pro Val Thr Pro Asn Gly Lys Leu Asp Arg Asp 
                485                 490                 495     


Ala Leu Pro Glu Pro Asp Trp Gly Gly Gly Ala Gly Arg Pro Pro Arg 
            500                 505                 510         


Gly Pro Arg Glu Glu Ile Leu Cys Gly Leu Phe Ala Glu Val Leu Gly 
        515                 520                 525             


Ala Pro Arg Val Gly Thr Asp Asp Asn Phe Phe Glu Leu Gly Gly His 
    530                 535                 540                 


Ser Met Leu Ala Thr Arg Leu Val Gly Arg Val Lys Thr Val Leu Gly 
545                 550                 555                 560 


Ala Asp Ile Gly Val Arg Thr Leu Phe Glu Ala Pro Thr Val Ala Ala 
                565                 570                 575     


Leu Ala Ala Arg Ile Asp Gly Ala Asp Ala Ala Ser Val Pro Glu Ala 
            580                 585                 590         


Glu Ala Val Pro Pro Tyr Gly Pro Ala Pro Leu Thr Pro Val Met Ala 
        595                 600                 605             


Arg Ile Ala Glu Leu Gly Leu Gly Gly Asp Asp Phe Asn Gln Ser Val 
    610                 615                 620                 


Val Val Ser Leu Pro Pro Ala Val Asp Arg Asp Arg Leu Val Pro Ala 
625                 630                 635                 640 


Leu Gln Arg Val Leu Asp His His Asp Ala Leu Arg Leu Arg Val Leu 
                645                 650                 655     


Pro Asp Gly Ser Thr Glu Val Arg Ala Pro Gly Ser Val Pro Ala Ala 
            660                 665                 670         


Asp Val Leu Ser Val Val Thr Arg Ala Pro Gly Ala Thr Gly Glu Ala 
        675                 680                 685             


Arg Asp Ala Leu Leu Val Glu Ala Ala Cys Ala Ala Arg Asp Arg Leu 
    690                 695                 700                 


Ala Pro Ala Glu Gly Arg Met Leu Gln Ala Val Leu Val Asp Gly Thr 
705                 710                 715                 720 


Asp Asp Thr Asp Gly Thr Gly Gly Thr Ser Gly Ala Asp Gly Val Leu 
                725                 730                 735     


Ile Leu Val Ala His His Leu Val Val Asp Ser Val Thr Trp Ser Ile 
            740                 745                 750         


Val Val Pro Asp Leu Ala Ala Ala Tyr Arg Gly Glu Glu Pro Ala Pro 
        755                 760                 765             


Val Gly Thr Ser Trp Arg Gln Trp Ala Thr Ser Leu Ala Arg Leu Ala 
    770                 775                 780                 


Thr Asp Pro Arg Val Glu Ala Glu Thr Ala His Trp Glu His Thr Leu 
785                 790                 795                 800 


Thr Gly Ala Gly Thr Leu Arg Leu Asp Arg Gly Arg Asp Leu Gln Gly 
                805                 810                 815     


Asp Ala Gly Arg Ile Ser Leu Asp Leu Ala Pro His Thr Thr Glu Ala 
            820                 825                 830         


Leu Leu Thr Arg Leu Pro Gly Gly Val Asn Ala Ser Val His Asp Val 
        835                 840                 845             


Leu Leu Thr Ala Phe Ala Phe Ala Val Ala Gly Trp Arg Arg Gly Arg 
    850                 855                 860                 


Gly Glu Asp Pro Asp Ala Pro Val Val Leu Asp Leu Glu Ser His Gly 
865                 870                 875                 880 


Arg His Glu Glu Ala Val Pro Gly Ala Glu Leu Ser Arg Thr Ala Gly 
                885                 890                 895     


Trp Phe Thr Ala Leu His Pro Val Arg Leu Ala Pro Asp Val Thr Asp 
            900                 905                 910         


Trp Ala Arg Leu His Gln Asp Gly Asp Ala Leu Arg Asp Gly Leu Lys 
        915                 920                 925             


Gln Val Lys Glu Gln Leu Arg Ser Val Pro Gly Asp Gly Leu Gly His 
    930                 935                 940                 


Gly Leu Leu Arg His Leu Asn Pro Thr Ala Gly Pro Arg Leu Ala Arg 
945                 950                 955                 960 


Leu Pro Glu Pro Asp Phe Gly Phe Asn Tyr Leu Gly Arg Arg Val Thr 
                965                 970                 975     


Pro Ala Thr Gly Thr Pro Glu Pro Trp Thr Val Thr Gly Gly Gly Leu 
            980                 985                 990         


Ala Ala Ser Arg Pro Thr Ala Pro  Met Ala His Ala Val  Glu Leu Ser 
        995                 1000                 1005             


Ala Val  Val His Glu Gly Ala  Asp Gly Pro Arg Leu  Arg Ala Glu 
    1010                 1015                 1020             


Trp Thr  Tyr Ala Arg Arg Leu  Val Pro Asp His Asp  Ala Arg Arg 
    1025                 1030                 1035             


Leu Ala  Glu Gln Trp Phe Arg  Ala Leu Glu Ala Leu  Val Glu Gln 
    1040                 1045                 1050             


Ala Asp  Arg Ala Gly Thr Gly  Gly Leu Thr Pro Ser  Asp Val Thr 
    1055                 1060                 1065             


Leu Gly  Ser Leu Ser Gln Ser  Glu Ile Glu Glu Phe  Glu Ser Asp 
    1070                 1075                 1080             


Leu Glu  Ser Glu Trp Leu Ile  Asn 
    1085                 1090     


<210>  5
<211>  3436
<212>  DNA
<213>  Artificial

<220>
<223>  Hybrid sequence

<400>  5
agtcttaagc tcgggcccca aataatgatt ttattttgac tgatagtgac ctgttcgttg     60

caacaaattg atgagcaatg cttttttata atgccaactt tgtacaaaaa agcaggctcc    120

gcggccgcct tgtttaactt taagaaggag cccttcacca tggcctgcct gccccgccgc    180

atcgccgaac aggccgcccg caccccgcac gcggtcgccg tcaccgaagc cggcggcacc    240

ctgatcacct acagcgaact cgacgcccgc gccaaccgcc tggcccgcca cctgatccgc    300

cgcggcgtca ccgcggagac ccgcgtcgcc gtcctcgccg aacgctccgc ccagctcgtc    360

gtcaccaccc tcgcgatcct caaggccggc ggcgtgtacg tgcccctgca caccggctat    420

cccgtcgacc ggatgcggca cgtcctcgcc gacaccgaag cggccctgct gctcaccgac    480

acccaccacg ccgccaccgc ggcccgcctg gacacccccg ccctcaccgt cgacgaggac    540

accacggccg gcgagcagga caccaccgcc ccggacgtca ccgtgcggcc cgaccagctc    600

gcctacatca tgttcacctc cggctcgacc ggcaccccca agggcatcgg catcacccac    660

cgcgacgcca tcgccctggc cgccgaccgc tgctgggacc tggacaccgg ctcccgcgtc    720

ctgatgcact ccccgtacgc cttcgacatc tccaccttcg aactgttcgc cccgctgctg    780

gccggcgggc ggatcgtcgt cgcaccccgc ggcgacatcg acgcggccgt cctgcagcgc    840

accctcgccg cccacggcgt cacctcgctg ctgctgaccg ccggcctgct cggcgtgatc    900

gccgacgagg caccggaggt cttcaccggc gtcaaggacg tgtggaccgg cggcgacgtc    960

gtctctccca ccgccgtgcg ccgcgtcctc gaagcctgcc ccggcaccgt cgtcaagacc   1020

ctctacgggc cgaccgagac caccctgggc tgcacctggc tgccgttcac cgacccccgc   1080

cgcatcccgc ccgccgtccc catcggccgg ccgctggaca acacccgcgc ctacgtcctc   1140

gacgaacggc tgcggcccgt accgcccggc gtcaccggcg agctgtacat cgccggcgcc   1200

ggcctcgccc gcggctactg ggaccagagc gcccgcaccg cggaacgctt caccgccgac   1260

ccgcacgccc acctgttcgg cgacacgggc ggccgcatgt accgcaccgg cgacctggcc   1320

cgccgcgacg ccgacggcgt cctccacttc tgcggccgcg ccgaccagca ggtcaagatc   1380

cgcggcttcc gcatcgaacc cggcgagatc gagaccgcgc tcgccgccca ccccgacgtc   1440

acccgcgccg ccgtcgtcgc ccgccccggc cgggccggcg acaaggtcct cgtcgcctac   1500

ctcgtcaccg cccccgacgc gggcgacacc accgccgaac aactgcgcgc cggcctcgag   1560

acccaactgc ccgactacat ggtccccgcc gcgttcgtcg cgctgcccgc cctgcccgtc   1620

acgcccaacg gcaaactcga ccgcgacgca ctgcccgaac ccgactgggg cggcggcgcc   1680

ggacgcccgc cccgcggccc ccgcgaggaa atcctgtgcg gcctgttcgc cgaggtcctc   1740

ggcgcccccc gggtcggcac cgacgacaac ttcttcgaac tcggcggcca ctccatgctc   1800

gccacccgcc tcgtcggccg cgtcaagacc gtcctcggcg ccgacatcgg cgtacgcacc   1860

ctcttcgagg cgccgaccgt cgccgccctc gccgcccgca tcgacggcgc cgacgcggcc   1920

tccgtgccgg aggccgaagc ggtgccgccg tacggtcccg ccccgctgac ccccgtgatg   1980

gcccgcatcg ccgaactggg cctgggcgga gacgacttca accagtcggt cgtggtgtcc   2040

ctgccgcccg cggtggaccg ggaccggctc gtcccggccc tgcaacgtgt gctcgaccac   2100

catgacgcgc tgcgcctgcg cgtcctgccc gacgggagca cggaggtacg cgccccgggc   2160

agtgtgccgg ccgcggacgt cctgagcgtc gtcacgcggg cccccggcgc caccggcgag   2220

gcgcgcgacg ccctgctcgt ggaggcggcg tgcgccgcac gggaccggct cgcaccggcc   2280

gagggccgca tgctccaggc ggtcctggtc gacggcacgg acgacacgga cggcacgggc   2340

gggacctccg gggcggacgg cgtgctgatc ctggtcgccc accacctggt ggtcgactcg   2400

gtgacgtgga gcatcgtcgt accggacctc gccgcggcct accggggcga ggagcccgcc   2460

ccggtgggca cctcgtggcg gcagtgggcc acctccctgg cacggctggc caccgacccc   2520

cgcgtcgagg cggagaccgc ccactgggag cacacgctca ccggggcggg caccctgcgg   2580

ctggaccgcg gccgcgatct ccagggcgac gccggacgca tcagcctcga cctggccccg   2640

cacacgaccg aggccctgct cacgcgcctg cccgggggcg tcaacgcgag cgtgcacgac   2700

gtcctgctga ccgccttcgc gttcgccgtc gccgggtggc ggcgcggacg cggcgaggac   2760

ccggacgcgc ccgtcgtgct cgacctggag agccacggcc ggcacgagga ggcggtgccg   2820

ggcgccgaac tcagccgcac ggcgggctgg ttcacggccc tccacccggt gcggctggct   2880

ccggacgtca ccgactgggc gcggctgcac caggacggcg acgcgctccg ggacggcctc   2940

aagcaggtga aggaacagtt gcggtccgta ccgggcgacg gcctcggcca cggcttgctg   3000

cgccacctca accccaccgc tgggccccgc ctcgcacgcc ttcccgagcc cgacttcggc   3060

ttcaactacc tgggccgccg ggtcaccccg gccaccggca ccccggaacc gtggaccgtc   3120

acgggcggcg gcctcgccgc ctcgcggccc acggcgccga tggcccacgc ggtggagctg   3180

agcgccgtcg tccacgaggg ggcggacggc ccccgactgc gcgcggagtg gacctacgca   3240

cgccgcctgg tccccgatca cgacgcccgc cgcctggccg agcaatggtt ccgggcgctg   3300

gaagccctgg tggagcaggc cgaccgggcc ggcaccggcg gcctgacccc gtccgacgtg   3360

accctcggct cgctcagcca gtccgagatc gaggaattcg agtccgacct tgagtccgag   3420

tggttaatta attgaa                                                   3436


<210>  6
<211>  1087
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid sequence

<400>  6

Ser Gln Gln Pro Thr Arg Ala Arg Gly Lys Ile Glu Asp Ile Leu Pro 
1               5                   10                  15      


Leu Ser Pro Leu Gln Glu Gly Phe Val Phe Leu Gly Leu Leu His Thr 
            20                  25                  30          


Glu Gly Pro Asp Leu Tyr Ile Gly Gln Val Ala Phe Asp Leu Glu Gly 
        35                  40                  45              


Pro Phe Asp Gly Ala Arg Met Arg Glu Ala Ala Arg Ala Leu Leu Arg 
    50                  55                  60                  


Arg His Ala Asn Leu Arg Ala Gly Phe Arg Gln Arg Lys Asn Gly Ala 
65                  70                  75                  80  


Trp Ala Gln Leu Val Leu Arg Asp Val Asp Leu Pro Trp Gln Asp Ala 
                85                  90                  95      


Asp Leu Ser Thr Leu Ser Glu Glu Glu Arg Arg Ala Glu Ala Asp Arg 
            100                 105                 110         


Leu Ala Ala Ala Asp Arg Ala Arg Arg Phe Asp Leu Gly Arg Pro Pro 
        115                 120                 125             


Leu Leu Arg Phe Thr Ala Ile Arg Leu Ser Ala Asp Arg Val Arg Leu 
    130                 135                 140                 


Val Met Thr Asn His His Ile Val Leu Asp Gly Trp Ser Met Pro Val 
145                 150                 155                 160 


Leu Leu Arg Glu Leu Met Ala Leu Tyr Ala Ala Glu Gly Asp Pro Ser 
                165                 170                 175     


Ala Leu Pro Arg Val Arg Pro Tyr Arg Asp Tyr Leu Ala Trp Leu Asp 
            180                 185                 190         


Ala Arg Asp Arg Asp Ala Ala Arg Asp Ala Trp Arg Arg Ser Leu Ser 
        195                 200                 205             


Gly Leu Asp Glu Ala Thr Leu Leu Ala Pro Asp Ala Gly Pro Ala Ser 
    210                 215                 220                 


Thr Ala Pro Ser Gln Val Ser Phe Thr Val Asp Ser Glu Val Ser Gly 
225                 230                 235                 240 


Ala Leu Ser Ala Trp Ala Arg Gly Gln Gly Val Thr Met Asn Thr Val 
                245                 250                 255     


Val Gln Gly Ala Trp Ala Leu Ala Leu Ala Gln Ala Thr Gly Arg Asp 
            260                 265                 270         


Asp Val Val Phe Gly Ala Thr Val Ser Gly Arg Pro Pro Glu Leu Pro 
        275                 280                 285             


Gly Val Glu Ser Met Ile Gly Leu Phe Ile Asn Thr Leu Pro Val Arg 
    290                 295                 300                 


Ala Arg Leu Asp Gln Ala Glu Pro Leu Gly Asp Leu Phe Arg Arg Leu 
305                 310                 315                 320 


Gln Asn Glu Gln Ala Arg Leu Leu Asp His Gln Trp Pro Gly Leu Ala 
                325                 330                 335     


Asp Ile Gln His Trp Ala Gly His Gly Glu Leu Phe Asp Thr Ala Met 
            340                 345                 350         


Val Phe Gln Asn Tyr Pro Val Glu Glu Gly Asp Leu Thr Ala Pro Ala 
        355                 360                 365             


Asp Pro Asp Arg Leu Arg Val Ala Ser Ala Asp Ile Lys Gly Gly Thr 
    370                 375                 380                 


His Phe Ala Val Asn Val Val Ala Thr Met Arg Gly Ala Glu Leu Ser 
385                 390                 395                 400 


Phe Arg Val Asp Tyr Arg Pro Asp Leu Tyr Asp Glu Ala Tyr Ala Arg 
                405                 410                 415     


Asp Phe Gly Arg Arg Met Leu Arg Val Leu Glu Thr Leu Ile Ser Asp 
            420                 425                 430         


Pro Asp Arg Pro Val Ala His Leu Asp Thr Leu Asp Pro Ala Val Arg 
        435                 440                 445             


Glu Arg Val Leu Val Glu Trp Asn Gly Ala Pro Thr Gln Leu Pro Gly 
    450                 455                 460                 


Thr Pro Leu His Glu Leu Thr Ser Leu Ile Ser Pro Ser Met Arg Ala 
465                 470                 475                 480 


Arg Phe Asp Ser Trp Asn Glu Thr Ala Glu Glu Phe Pro Ala Asp Lys 
                485                 490                 495     


Thr Leu His Ala Val Phe Glu Glu Met Ala Glu Arg Trp Pro Asp Glu 
            500                 505                 510         


Ile Ala Val Val Tyr Arg Glu Asn Arg Leu Thr Tyr Arg Glu Leu Asn 
        515                 520                 525             


Glu Arg Ala Asn Arg Leu Ala His Tyr Leu Arg Ser Val Val Glu Leu 
    530                 535                 540                 


Arg Pro Asp Asp Leu Val Ala Leu Val Leu Asp Lys Ser Glu Leu Met 
545                 550                 555                 560 


Ile Thr Ala Ile Ile Ala Ala Trp Lys Thr Gly Ala Ala Tyr Val Pro 
                565                 570                 575     


Ile Asp Ser Gly Tyr Pro Asp Asp Arg Ile Ser Phe Met Leu Ser Asp 
            580                 585                 590         


Thr Ala Ala Arg Val Val Val Thr Asn Glu Ile His Ser Asp Arg Leu 
        595                 600                 605             


Arg Ser Leu Ala Glu Thr Gly Thr Pro Val Leu Glu Ile Glu Leu Leu 
    610                 615                 620                 


His Leu Asp Asp Gln Pro Ala Val Asn Pro Val Thr Glu Thr Thr Ser 
625                 630                 635                 640 


Thr Asp Leu Ala Tyr Ala Ile Tyr Thr Ser Gly Thr Thr Gly Lys Pro 
                645                 650                 655     


Lys Ala Val Leu Val Glu His Arg Gly Val Val Asn Leu Gln Val Ser 
            660                 665                 670         


Leu Ala Lys Leu Phe Gly Leu Asp Lys Ala His Arg Asp Glu Ala Leu 
        675                 680                 685             


Leu Ser Phe Ser Asn Tyr Ile Phe Asp His Phe Val Glu Gln Met Thr 
    690                 695                 700                 


Asp Ala Leu Leu Asn Gly Gln Lys Leu Val Val Leu Asp Gly Ser Met 
705                 710                 715                 720 


Arg Thr Asp Pro Gly Arg Leu Cys Arg Tyr Met Asn Asp Glu Gln Val 
                725                 730                 735     


Thr Tyr Leu Ser Gly Thr Pro Ser Val Leu Ser Leu Tyr Asp Tyr Ser 
            740                 745                 750         


Ser Ala Thr Ser Leu Thr Arg Ile Asp Ala Ile Gly Glu Asp Phe Thr 
        755                 760                 765             


Glu Pro Val Phe Ala Lys Ile Arg Gly Thr Phe Pro Gly Leu Ile Ile 
    770                 775                 780                 


Asn Gly Tyr Gly Pro Thr Glu Ile Ser Ile Thr Ser His Lys Arg Pro 
785                 790                 795                 800 


Tyr Pro Pro Asp Val His Arg Val Asn Lys Ser Ile Gly Phe Pro Val 
                805                 810                 815     


Ala Asn Thr Lys Cys His Val Leu Asn Lys Ala Met Lys Pro Val Pro 
            820                 825                 830         


Val Gly Gly Ile Gly Glu Leu Tyr Ile Gly Gly Ile Gly Val Thr Arg 
        835                 840                 845             


Gly Tyr Leu Asn Arg Glu Asp Leu Thr Ala Asp Arg Phe Val Glu Asn 
    850                 855                 860                 


Pro Phe Gln Thr Ala Glu Glu Arg Arg Leu Gly Glu Asn Gly Arg Leu 
865                 870                 875                 880 


Tyr Lys Thr Gly Asp Leu Val Arg Trp Leu Pro Asn Gly Glu Val Glu 
                885                 890                 895     


Tyr Leu Gly Arg Thr Asp Leu Gln Val Lys Ile Arg Gly Gln Arg Val 
            900                 905                 910         


Glu Leu Gly Glu Val Glu Ala Ala Leu Ser Ser Tyr Pro Gly Val Val 
        915                 920                 925             


Arg Ser Leu Val Val Ala Arg Glu His Ala Val Gly Gln Lys Tyr Leu 
    930                 935                 940                 


Val Gly Phe Tyr Val Gly Glu Gln Glu Phe Asp Glu Gln Asp Leu Lys 
945                 950                 955                 960 


Gln Trp Met Arg Lys Lys Leu Pro Glu Ser Val Val Pro Ala Arg Val 
                965                 970                 975     


Leu Arg Ile Thr Asp Ile Pro Val Thr Pro Ser Gly Lys Leu Asp Ala 
            980                 985                 990         


Arg Arg Leu Pro Glu Thr Asp Phe  Gly Ala Gly Glu Gly  Ala Glu Tyr 
        995                 1000                 1005             


Val Ala  Pro Val Ser Glu Phe  Glu Leu Lys Leu Cys  Gly Ile Trp 
    1010                 1015                 1020             


Ala Gln  Val Leu Glu Ile Ala  Pro Asp Arg Ile Gly  Val His Asp 
    1025                 1030                 1035             


Asp Phe  Phe Ala Leu Gly Gly  Asp Ser Ile Arg Ala  Met Ala Leu 
    1040                 1045                 1050             


Ala Gln  Ala Ile Thr Thr Gly  Phe Gly Gln Gly Leu  Gly Val Ala 
    1055                 1060                 1065             


Thr Val  Leu Gln His Thr Thr  Leu Ala Ala Gln Ala  Glu His Ile 
    1070                 1075                 1080             


Gln Ala  Ala Ala 
    1085         


<210>  7
<211>  3263
<212>  DNA
<213>  Artificial

<220>
<223>  Hybrid sequence

<400>  7
agccagcaac cgacccgtgc gcgcggcaag atcgaggaca tccttccgct ctccccgctg     60

caagagggct tcgtgttcct cgggctgctg cacaccgagg ggcccgacct ctacatcggc    120

caggtggcct tcgacctgga gggccccttc gacggcgccc ggatgcgcga ggcggcccgg    180

gcgctgctgc gccggcacgc caacctgcgc gccgggttcc ggcagcgcaa gaacggggcc    240

tgggcccaac tggtcctgcg cgacgtcgac ctgccgtggc aggacgccga cctgagcacg    300

ctgtccgagg aggagcgccg ggcggaggcc gaccggctcg cggccgccga ccgtgcccgc    360

cgtttcgacc tgggccggcc cccgctgctg cgcttcaccg ccatccggct gtccgccgac    420

cgcgtccgcc tggtgatgac caaccaccac atcgtgctgg acggctggtc catgccggtc    480

ctgctgcgcg aactcatggc gctctacgcc gccgagggtg acccctccgc gctcccccgg    540

gtccgtccct accgcgacta cctggcctgg ctcgacgccc gcgaccggga cgccgcccgc    600

gacgcctggc ggcggtccct gtccgggctc gacgaggcca ccctcctcgc cccggacgcc    660

ggcccggcgt cgaccgctcc ctcgcaggtg tccttcaccg tggactccga ggtcagcggc    720

gccctgtcgg cctgggctcg gggccagggc gtgaccatga acacggtggt ccagggtgcc    780

tgggccctcg cgctggccca ggccaccgga cgcgacgacg tcgtcttcgg cgccaccgtc    840

tccggccgcc cgcccgagct gcccggcgtc gagtccatga tcggcctgtt catcaacacc    900

ctgcccgtcc gcgcccgcct cgaccaggcc gaacccctcg gcgacctctt ccgccgcctc    960

cagaacgaac aggcccgcct cctggaccac cagtggcccg gactcgccga catccagcac   1020

tgggccggac acggcgaact cttcgacacc gccatggtct tccagaacta cccggtcgag   1080

gagggcgacc tcaccgcccc cgccgacccg gaccggctcc gggtcgcctc ggccgacatc   1140

aagggcggca cgcacttcgc cgtcaacgtc gtcgcgacga tgcgcggcgc cgaactgtcc   1200

ttccgcgtcg actaccgacc cgacctctac gacgaggcgt acgcccgcga cttcggccga   1260

cggatgctac gggtactgga aaccctgatc tccgacccgg accgtcccgt ggcccacctg   1320

gacaccctcg acccggccgt acgggagcgg gtcctggtgg agtggaacgg ggccccgacc   1380

cagcttcccg gaacgccgct gcacgaactg actagtctca tctcaccgtc gatgcgcgcg   1440

cggttcgatt cgtggaacga gaccgccgag gaattccccg cggacaagac gctgcacgcg   1500

gtgttcgagg agatggccga gcgctggccg gacgagatcg ccgtggtgta ccgggaaaac   1560

cggctgacct accgcgagct gaacgagcgg gccaaccgcc tcgcgcacta cctgcgctcg   1620

gtggtcgaac tgcgcccgga cgacctcgtc gcgctggtgc tggacaagag cgaactgatg   1680

atcaccgcga tcatcgcggc gtggaagacc ggtgcggcct acgtgccgat cgactccggc   1740

tacccggacg accggatctc gttcatgctc tccgacaccg ccgcgcgcgt ggtggtgacc   1800

aacgagatcc acagcgaccg gctgcgttcg ctggcggaga ccggcacgcc cgtgctggag   1860

atcgaactgc tgcacctcga cgaccagccg gcggtgaacc cggtcaccga gaccaccagc   1920

accgacctcg cctacgcgat ctacacctcc ggcaccaccg gcaagcccaa ggcggtgctt   1980

gtcgaacacc gcggcgtggt caacctccag gtgtcgctgg cgaagctgtt cggtctggac   2040

aaggcgcacc gcgacgaggc gctgctgtcg ttctcgaact acatcttcga ccacttcgtc   2100

gagcagatga ccgacgcgct gctcaacggg cagaagctgg tggtgctcga cggcagcatg   2160

cgcaccgatc ccgggcgcct gtgccggtac atgaacgacg agcaggtcac ctacctctcg   2220

ggcacgccgt cggtgctctc gctctacgac tactcgtcgg cgacctcgct gacccggatc   2280

gacgcgatcg gcgaggactt caccgagccg gtgttcgcca agatccgcgg caccttcccc   2340

ggcctgatca tcaacggcta cgggccgacg gaaatctcga tcaccagcca caaacggccc   2400

tacccgccgg acgtgcaccg ggtgaacaag agcatcggct tcccggtcgc caacaccaag   2460

tgccacgtgc tgaacaaggc gatgaagccg gtcccggtcg gcggtatcgg cgagctctac   2520

atcggcggca tcggcgtgac cagggggtac ctcaaccgcg aggacctgac cgccgaccgg   2580

ttcgtggaga acccgttcca gaccgcggag gaacggcggc tgggcgagaa cggccgcctg   2640

tacaagaccg gcgacctggt gcgctggctg cccaacggcg aggtggagta cctcggccgc   2700

accgacctgc aggtcaagat ccgcggccag cgcgtggaac tcggcgaggt ggaggcggcg   2760

ctgtcgtcct accccggggt ggtgcgctcg ctggtcgtgg cccgagagca cgcggtgggg   2820

cagaagtacc tggtcgggtt ctacgtcggc gagcaggagt tcgacgagca ggacctcaag   2880

cagtggatgc gcaagaagtt gcccgagtcc gtggtgcccg cgcgcgtcct gcggatcacc   2940

gacatcccgg tgaccccgag cggcaagctg gacgcgcggc gcctgccgga gacggacttc   3000

ggggccggtg agggcgccga atacgtcgcg ccggtcagcg agttcgagct gaagctgtgc   3060

ggtatctggg cccaggtgct ggagatcgcg ccggaccgca tcggcgtgca cgacgacttc   3120

ttcgcgctcg gcggcgacag catccgcgcg atggcgctcg cgcaggcgat caccaccggc   3180

ttcggccagg gcctcggtgt ggcgaccgtg ctccagcaca ccacgctcgc cgcccaggcc   3240

gagcacatcc aggcggccgc gct                                           3263


<210>  8
<211>  1095
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid sequence

<400>  8

Ile Glu His Cys Ala Ala Gln Glu His Ile His Leu Thr Pro Ser Asp 
1               5                   10                  15      


Ile Ser Leu Lys Asp Ile Thr Ile Glu Glu Leu Asp Gln Phe Val Lys 
            20                  25                  30          


Gln Thr Gln His Ile Gly Asp Ile Glu Asn Ile Tyr Pro Leu Thr Pro 
        35                  40                  45              


Met Gln Lys Gly Met Leu Phe His Ser Leu Ile Asp Ser Ala Ser Arg 
    50                  55                  60                  


Ala Tyr Phe Glu Gln Ala Ala Phe Asp Leu Lys Gly Asp Leu Asp Ile 
65                  70                  75                  80  


Glu Ala Phe Thr Met Ser Leu Ser Tyr Leu Ala Glu Ser His Glu Ile 
                85                  90                  95      


Leu Arg Thr His Phe Tyr Thr Glu Trp Lys Asp Gln Pro Leu Gln Ile 
            100                 105                 110         


Val Phe Arg Lys Lys Pro Ile Glu Ile Thr Val Glu Asp Ile Arg Ser 
        115                 120                 125             


Met Lys Asn Lys Gln Arg Asn Glu Phe Ile Ala Gly Phe Val Gln Lys 
    130                 135                 140                 


Asp Lys Ala Arg Gly Phe Asp Leu Thr Gln Asp Ala Leu Met Arg Val 
145                 150                 155                 160 


Ser Ile Leu Arg Thr Glu Asp Asp Gln Val Arg Leu Ile Trp Ser Phe 
                165                 170                 175     


His His Ile Leu Met Asp Gly Trp Cys Leu Pro Leu Ile Thr Lys Glu 
            180                 185                 190         


Val Phe Glu Thr Tyr Tyr Glu Leu Leu Glu Arg Arg Gln Pro Glu Arg 
        195                 200                 205             


Glu Ala Val Thr Pro Tyr Ser Arg Tyr Ile Glu Trp Leu Glu Asp Gln 
    210                 215                 220                 


Asp His Gln Asn Ala Leu Ala Tyr Trp Gln Lys Tyr Leu Asp Gly Tyr 
225                 230                 235                 240 


Glu Gly Gln Thr Val Leu Leu Lys Glu Pro Val Ser Asn Gln Ala Lys 
                245                 250                 255     


Gly Tyr Gln Lys Gln Arg Leu Ala Cys Arg Leu Gly Lys Gln Leu Ser 
            260                 265                 270         


Glu Glu Ile Arg Gln Thr Ala Ser Lys His His Val Thr Val Asn Thr 
        275                 280                 285             


Phe Ile Gln Ser Ala Trp Gly Leu Leu Leu Gln Arg Tyr Asn Asn Ser 
    290                 295                 300                 


Gln Asp Val Val Phe Gly Ser Val Val Ser Gly Arg Pro Ala Glu Ile 
305                 310                 315                 320 


Pro Gly Ile Glu Ser Met Val Gly Leu Phe Ile Asn Thr Ile Pro Val 
                325                 330                 335     


Arg Ile Thr Ala Gln Pro Gly Met Thr Val Glu Gln Val Leu Lys Met 
            340                 345                 350         


Ser Gln Glu Gln Ala Leu Ala Ser Gln Ala Tyr Asp Thr Phe Pro Leu 
        355                 360                 365             


Tyr Glu Ile Gln Ala Gln Thr Glu Gln Lys Gln Gln Leu Ile Ser His 
    370                 375                 380                 


Ile Met Val Phe Glu Asn Tyr Pro Val Glu Lys Gln Met Glu His Met 
385                 390                 395                 400 


Lys Pro Asn Arg Asp Ala Leu Asp Ile Ile Asn Phe His Met Glu Glu 
                405                 410                 415     


His Thr His Tyr Asp Phe Asn Phe Ile Val Met Pro Ala Gly Glu Ile 
            420                 425                 430         


Asp Ile His Phe Val Tyr Asn Ser Asn Val Tyr Asp His Ala Ser Val 
        435                 440                 445             


Lys Arg Met Glu Glu His Phe Met Gln Ile Ile Lys Gln Met Val Asn 
    450                 455                 460                 


Ser Gln Ala Ile Arg Val Gln Asp Leu Asp Ile Leu Thr Gly Thr Ser 
465                 470                 475                 480 


Leu Ile Ser Pro Ser Met Arg Ala Arg Phe Asp Ser Trp Asn Glu Thr 
                485                 490                 495     


Ala Glu Glu Phe Pro Ala Asp Lys Thr Leu His Ala Val Phe Glu Glu 
            500                 505                 510         


Met Ala Glu Arg Trp Pro Asp Glu Ile Ala Val Val Tyr Arg Glu Asn 
        515                 520                 525             


Arg Leu Thr Tyr Arg Glu Leu Asn Glu Arg Ala Asn Arg Leu Ala His 
    530                 535                 540                 


Tyr Leu Arg Ser Val Val Glu Leu Arg Pro Asp Asp Leu Val Ala Leu 
545                 550                 555                 560 


Val Leu Asp Lys Ser Glu Leu Met Ile Thr Ala Ile Ile Ala Ala Trp 
                565                 570                 575     


Lys Thr Gly Ala Ala Tyr Val Pro Ile Asp Ser Gly Tyr Pro Asp Asp 
            580                 585                 590         


Arg Ile Ser Phe Met Leu Ser Asp Thr Ala Ala Arg Val Val Val Thr 
        595                 600                 605             


Asn Glu Ile His Ser Asp Arg Leu Arg Ser Leu Ala Glu Thr Gly Thr 
    610                 615                 620                 


Pro Val Leu Glu Ile Glu Leu Leu His Leu Asp Asp Gln Pro Ala Val 
625                 630                 635                 640 


Asn Pro Val Thr Glu Thr Thr Ser Thr Asp Leu Ala Tyr Ala Ile Tyr 
                645                 650                 655     


Thr Ser Gly Thr Thr Gly Lys Pro Lys Ala Val Leu Val Glu His Arg 
            660                 665                 670         


Gly Val Val Asn Leu Gln Val Ser Leu Ala Lys Leu Phe Gly Leu Asp 
        675                 680                 685             


Lys Ala His Arg Asp Glu Ala Leu Leu Ser Phe Ser Asn Tyr Ile Phe 
    690                 695                 700                 


Asp His Phe Val Glu Gln Met Thr Asp Ala Leu Leu Asn Gly Gln Lys 
705                 710                 715                 720 


Leu Val Val Leu Asp Gly Ser Met Arg Thr Asp Pro Gly Arg Leu Cys 
                725                 730                 735     


Arg Tyr Met Asn Asp Glu Gln Val Thr Tyr Leu Ser Gly Thr Pro Ser 
            740                 745                 750         


Val Leu Ser Leu Tyr Asp Tyr Ser Ser Ala Thr Ser Leu Thr Arg Ile 
        755                 760                 765             


Asp Ala Ile Gly Glu Asp Phe Thr Glu Pro Val Phe Ala Lys Ile Arg 
    770                 775                 780                 


Gly Thr Phe Pro Gly Leu Ile Ile Asn Gly Tyr Gly Pro Thr Glu Ile 
785                 790                 795                 800 


Ser Ile Thr Ser His Lys Arg Pro Tyr Pro Pro Asp Val His Arg Val 
                805                 810                 815     


Asn Lys Ser Ile Gly Phe Pro Val Ala Asn Thr Lys Cys His Val Leu 
            820                 825                 830         


Asn Lys Ala Met Lys Pro Val Pro Val Gly Gly Ile Gly Glu Leu Tyr 
        835                 840                 845             


Ile Gly Gly Ile Gly Val Thr Arg Gly Tyr Leu Asn Arg Glu Asp Leu 
    850                 855                 860                 


Thr Ala Asp Arg Phe Val Glu Asn Pro Phe Gln Thr Ala Glu Glu Arg 
865                 870                 875                 880 


Arg Leu Gly Glu Asn Gly Arg Leu Tyr Lys Thr Gly Asp Leu Val Arg 
                885                 890                 895     


Trp Leu Pro Asn Gly Glu Val Glu Tyr Leu Gly Arg Thr Asp Leu Gln 
            900                 905                 910         


Val Lys Ile Arg Gly Gln Arg Val Glu Leu Gly Glu Val Glu Ala Ala 
        915                 920                 925             


Leu Ser Ser Tyr Pro Gly Val Val Arg Ser Leu Val Val Ala Arg Glu 
    930                 935                 940                 


His Ala Val Gly Gln Lys Tyr Leu Val Gly Phe Tyr Val Gly Glu Gln 
945                 950                 955                 960 


Glu Phe Asp Glu Gln Asp Leu Lys Gln Trp Met Arg Lys Lys Leu Pro 
                965                 970                 975     


Glu Ser Val Val Pro Ala Arg Val Leu Arg Ile Thr Asp Ile Pro Val 
            980                 985                 990         


Thr Pro Ser Gly Lys Leu Asp Ala  Arg Arg Leu Pro Glu  Thr Asp Phe 
        995                 1000                 1005             


Gly Ala  Gly Glu Gly Ala Glu  Tyr Val Ala Pro Val  Ser Glu Phe 
    1010                 1015                 1020             


Glu Leu  Lys Leu Cys Gly Ile  Trp Ala Gln Val Leu  Glu Ile Ala 
    1025                 1030                 1035             


Pro Asp  Arg Ile Gly Val His  Asp Asp Phe Phe Ala  Leu Gly Gly 
    1040                 1045                 1050             


Asp Ser  Ile Arg Ala Met Ala  Leu Ala Gln Ala Ile  Thr Thr Gly 
    1055                 1060                 1065             


Phe Gly  Gln Gly Leu Gly Val  Ala Thr Val Leu Gln  His Thr Thr 
    1070                 1075                 1080             


Leu Ala  Ala Gln Ala Glu His  Ile Gln Ala Ala Ala  
    1085                 1090                 1095 


<210>  9
<211>  3287
<212>  DNA
<213>  Artificial

<220>
<223>  Hybrid sequence

<400>  9
atcgaacatt gcgcagctca agaacacatt cacctgacgc caagcgatat ttcgctgaag     60

gacataacaa tcgaggaatt agatcaattt gttaagcaaa cacagcatat cggcgacatt    120

gaaaatatat atcctttaac tcccatgcag aaaggtatgc tgttccatag tttaatcgat    180

tcggcttcca gagcttactt tgaacaagcc gcttttgacc tcaaaggcga cttggatatt    240

gaggcattta caatgagttt gtcgtatctg gcggaaagcc atgagattct ccggactcat    300

ttttatacgg aatggaaaga tcagcctttg cagatcgtat tccgaaaaaa accgatcgaa    360

ataaccgttg aagatattcg aagcatgaag aataaacaac gaaacgagtt cattgccggc    420

tttgtacaaa aagataaggc aagaggattc gaccttaccc aagatgcgtt aatgcgcgta    480

tcaatccttc gtacagagga cgaccaagtc cgattgatat ggagcttcca tcatatttta    540

atggatggct ggtgtctgcc tcttattacg aaagaagtgt ttgaaaccta ttatgagctt    600

cttgagagaa gacaaccgga gcgggaagcc gtcaccccgt acagccgata tatcgaatgg    660

ctggaagacc aggatcatca gaacgctttg gcctattggc aaaaatattt ggacggttat    720

gaaggacaaa ccgttttact gaaagaacct gtctcaaacc aagccaaggg atatcaaaaa    780

caaaggcttg catgccggct cggaaagcag ctatcagaag aaatcagaca gactgcaagc    840

aagcatcacg tcaccgtgaa tacattcatt caaagtgcgt gggggctatt gctgcaaaga    900

tacaacaaca gtcaggatgt cgttttcggg tcggttgtat ccggacgccc ggcagaaatt    960

ccgggtattg aatccatggt cggcttattt atcaacacca ttcccgtacg tattaccgct   1020

cagcctggaa tgactgtgga acaagtgttg aaaatgagcc aggagcaggc attggcttct   1080

caggcgtatg atacatttcc gttgtatgaa attcaggctc aaaccgaaca aaagcagcag   1140

ctgatcagtc atatcatggt atttgaaaat tatccggtcg agaaacaaat ggagcatatg   1200

aaaccgaatc gtgacgcgct ggacattatc aatttccata tggaagagca tacccattac   1260

gatttcaatt tcattgtcat gccggctgga gaaatcgaca ttcattttgt atacaatagc   1320

aacgtctatg atcatgcaag tgtcaagcgg atggaagagc attttatgca aatcattaag   1380

cagatggtga acagtcaggc gattcgcgtc caagacttgg atatacttac gggaactagt   1440

ctcatctcac cgtcgatgcg cgcgcggttc gattcgtgga acgagaccgc cgaggaattc   1500

cccgcggaca agacgctgca cgcggtgttc gaggagatgg ccgagcgctg gccggacgag   1560

atcgccgtgg tgtaccggga aaaccggctg acctaccgcg agctgaacga gcgggccaac   1620

cgcctcgcgc actacctgcg ctcggtggtc gaactgcgcc cggacgacct cgtcgcgctg   1680

gtgctggaca agagcgaact gatgatcacc gcgatcatcg cggcgtggaa gaccggtgcg   1740

gcctacgtgc cgatcgactc cggctacccg gacgaccgga tctcgttcat gctctccgac   1800

accgccgcgc gcgtggtggt gaccaacgag atccacagcg accggctgcg ttcgctggcg   1860

gagaccggca cgcccgtgct ggagatcgaa ctgctgcacc tcgacgacca gccggcggtg   1920

aacccggtca ccgagaccac cagcaccgac ctcgcctacg cgatctacac ctccggcacc   1980

accggcaagc ccaaggcggt gcttgtcgaa caccgcggcg tggtcaacct ccaggtgtcg   2040

ctggcgaagc tgttcggtct ggacaaggcg caccgcgacg aggcgctgct gtcgttctcg   2100

aactacatct tcgaccactt cgtcgagcag atgaccgacg cgctgctcaa cgggcagaag   2160

ctggtggtgc tcgacggcag catgcgcacc gatcccgggc gcctgtgccg gtacatgaac   2220

gacgagcagg tcacctacct ctcgggcacg ccgtcggtgc tctcgctcta cgactactcg   2280

tcggcgacct cgctgacccg gatcgacgcg atcggcgagg acttcaccga gccggtgttc   2340

gccaagatcc gcggcacctt ccccggcctg atcatcaacg gctacgggcc gacggaaatc   2400

tcgatcacca gccacaaacg gccctacccg ccggacgtgc accgggtgaa caagagcatc   2460

ggcttcccgg tcgccaacac caagtgccac gtgctgaaca aggcgatgaa gccggtcccg   2520

gtcggcggta tcggcgagct ctacatcggc ggcatcggcg tgaccagggg gtacctcaac   2580

cgcgaggacc tgaccgccga ccggttcgtg gagaacccgt tccagaccgc ggaggaacgg   2640

cggctgggcg agaacggccg cctgtacaag accggcgacc tggtgcgctg gctgcccaac   2700

ggcgaggtgg agtacctcgg ccgcaccgac ctgcaggtca agatccgcgg ccagcgcgtg   2760

gaactcggcg aggtggaggc ggcgctgtcg tcctaccccg gggtggtgcg ctcgctggtc   2820

gtggcccgag agcacgcggt ggggcagaag tacctggtcg ggttctacgt cggcgagcag   2880

gagttcgacg agcaggacct caagcagtgg atgcgcaaga agttgcccga gtccgtggtg   2940

cccgcgcgcg tcctgcggat caccgacatc ccggtgaccc cgagcggcaa gctggacgcg   3000

cggcgcctgc cggagacgga cttcggggcc ggtgagggcg ccgaatacgt cgcgccggtc   3060

agcgagttcg agctgaagct gtgcggtatc tgggcccagg tgctggagat cgcgccggac   3120

cgcatcggcg tgcacgacga cttcttcgcg ctcggcggcg acagcatccg cgcgatggcg   3180

ctcgcgcagg cgatcaccac cggcttcggc cagggcctcg gtgtggcgac cgtgctccag   3240

cacaccacgc tcgccgccca ggccgagcac atccaggcgg ccgcgct                 3287


<210>  10
<211>  1706
<212>  PRT
<213>  Nocardia lactamdurans

<400>  10

Glu His Thr Ala Trp Thr Pro Pro Pro Thr Ala Val Glu His Pro Pro 
1               5                   10                  15      


Val Ser Leu Ala Gln Glu Arg Leu Leu Phe Ile Asp Asp Phe Glu Gly 
            20                  25                  30          


Gly Thr Ala Ala Tyr Asn Ile Pro Phe Val Leu Arg Leu Pro Ala His 
        35                  40                  45              


Thr Arg Ala Ala Leu Pro Gly Ala Leu Gly Thr Leu Val Arg Arg His 
    50                  55                  60                  


Pro Ala Leu Arg Thr Leu Leu Lys Thr Asp Asp Gln Gly Val Arg Arg 
65                  70                  75                  80  


Gln Tyr Pro Ile Pro Ala Asp Asp Val Arg Leu Glu Val Pro Ser Thr 
                85                  90                  95      


Thr Val Asp Ser Arg Ala Glu Leu Asp Glu Val Leu Thr Glu Arg Ala 
            100                 105                 110         


Gly Tyr Val Phe Arg Leu His Glu Glu Leu Pro Ile Arg Ala Glu Ala 
        115                 120                 125             


Phe Asp His Gly Asp Glu Ile Tyr Leu Ser Val Val Val His His Ser 
    130                 135                 140                 


Cys Phe Asp Gly Trp Ser Trp Asp Ile Phe Arg Arg Glu Leu Ala Ala 
145                 150                 155                 160 


Leu Leu Asp Gly Val Pro Glu Ala Asp Leu Gly Ala Leu Arg Gly Thr 
                165                 170                 175     


Tyr Gly Glu Phe Ala Val Trp Gln Arg Gln Tyr Leu Thr Gly Lys Arg 
            180                 185                 190         


Leu Ala Ala Leu Thr Glu Phe Trp Thr Gly Ala Leu Gly Gly Phe Glu 
        195                 200                 205             


Thr Ile Ala Leu Pro Leu Asp His Pro Arg Pro Pro Arg Phe Asp Tyr 
    210                 215                 220                 


Arg Gly Arg Glu Leu Glu Phe Glu Leu Asp Glu Arg Thr Thr Glu Ala 
225                 230                 235                 240 


Leu Arg Glu Leu Ala Arg Thr Ala Arg Val Ser Leu Tyr Ser Val Leu 
                245                 250                 255     


Leu Gly Ala Trp Cys Leu Met Leu Asn Met Tyr Thr Gly Gln His Asp 
            260                 265                 270         


Leu Val Val Gly Thr Pro Ser Ala Asn Arg Gly Arg Pro Glu Phe Asp 
        275                 280                 285             


Arg Ala Val Gly Phe Phe Ala Asn Leu Leu Ala Leu Arg Val Arg Val 
    290                 295                 300                 


Asp Pro Ala Ala Thr Leu Pro Ala Tyr Val Arg Ser Val Gly Glu Ala 
305                 310                 315                 320 


Val Val Ala Ala Gln Val His Gly Glu Leu Pro Phe Glu Gln Leu Val 
                325                 330                 335     


Lys Glu Leu Lys Val Glu Lys Asp Pro Ser Arg His Pro Ile Leu Gln 
            340                 345                 350         


Leu Asn Phe Thr Leu Gln Asn Val Ser Asp His Thr Ser Ala Leu Thr 
        355                 360                 365             


Gly Tyr Gln Pro Asp Ser Gly Gly Trp Thr Thr Thr Lys Phe Asp Leu 
    370                 375                 380                 


Ser Ala Thr Met Thr Glu Thr Ala Thr Gly Leu Ala Gly Asn Leu Thr 
385                 390                 395                 400 


Tyr Ala Ala Ser Leu Phe Asp Asp Thr Ser Ala Ser Gly Phe Ile Ala 
                405                 410                 415     


Thr Phe Lys His Val Leu Ala Glu Phe Ala Ser Ala Ala Ala Gln Thr 
            420                 425                 430         


Pro Ile Ala Gln Leu Thr Ala Leu Asp Glu Pro Gly Gln Ala Ala Leu 
        435                 440                 445             


Leu Thr Pro Pro Ala Glu Pro Ala Ala Arg Arg Thr Arg Thr Leu His 
    450                 455                 460                 


Ala Val Phe Glu Glu Val Ala Ala Thr Trp Pro Asp Arg Val Ala Val 
465                 470                 475                 480 


Val His Gly Asp Val Arg Leu Thr Tyr Arg Glu Leu Asn Glu Arg Ala 
                485                 490                 495     


Asn Arg Leu Ala His His Leu Arg Ser Val Ala Glu Pro Arg Ala Asp 
            500                 505                 510         


Glu Leu Ile Ala Leu Val Leu Asp Lys Ser Glu Leu Thr Leu Val Ala 
        515                 520                 525             


Ile Leu Ala Val Trp Lys Ala Gly Ala Ala Tyr Met Pro Ile Asp Pro 
    530                 535                 540                 


Ser Tyr Pro Asp Asp Arg Ile Ala Phe Met Leu Ser Asp Thr Gly Ala 
545                 550                 555                 560 


Lys Leu Val Leu Ala Gly Glu Ala His Gly Ser Arg Val Arg Gly Leu 
                565                 570                 575     


Thr Ser Gly Asp Val Leu Asp Leu Glu Gln Leu Asp Leu Thr Gly Glu 
            580                 585                 590         


Pro Ala Glu Asn Pro Val Thr Glu Thr Thr Ser Thr Glu Leu Ala Tyr 
        595                 600                 605             


Ala Ile Tyr Thr Ser Gly Thr Thr Gly Lys Pro Lys Ala Val Leu Val 
    610                 615                 620                 


Ser His Gly Ser Val Asp Ser Phe Arg Ala Gln Leu Ser Gly Arg Tyr 
625                 630                 635                 640 


Phe Gly Ser Pro Asp Glu Ser Ala Glu Ala Val Leu Phe Leu Ala Asn 
                645                 650                 655     


Tyr Val Phe Asp Phe Ser Val Glu Gln Leu Ala Leu Ser Val Leu Gly 
            660                 665                 670         


Gly His Lys Leu Leu Val Pro Pro Pro Ser Ala Ala Asp Asp Pro Ala 
        675                 680                 685             


Phe Tyr Glu Leu Ala Asn Arg Glu Gly Leu Ser Tyr Leu Ser Gly Thr 
    690                 695                 700                 


Pro Thr Gln Val Glu Arg Phe Asp Leu Ala His Leu Ser His Leu Arg 
705                 710                 715                 720 


Cys Val Leu Val Ala Gly Glu Ala Phe Gln Pro Gln His Phe Glu Lys 
                725                 730                 735     


Met Arg Gly Glu Phe Ala Gly Pro Ile Leu Asn Ala Tyr Gly Thr Thr 
            740                 745                 750         


Glu Thr Thr Val Tyr Asn Thr Val His Arg Phe Glu Pro Gly Asp Ala 
        755                 760                 765             


Tyr Arg Asn Thr Leu Gly Ala Pro Leu Gly Asn Thr Arg Leu Tyr Val 
    770                 775                 780                 


Leu Gly Asp Gly Met Lys Leu Leu Pro Thr Gly Ala Val Gly Glu Leu 
785                 790                 795                 800 


Tyr Leu Ala Gly Asp Cys Val Thr Glu Gly Tyr Leu His Arg Pro Glu 
                805                 810                 815     


Leu Thr Arg Glu Arg Phe Leu Pro Asn Pro Phe Ala Ala Glu Ser Gly 
            820                 825                 830         


Arg Phe Pro Met Ile Tyr Arg Thr Gly Asp Val Val Arg Arg Gly Pro 
        835                 840                 845             


Asp Gly Glu Leu Gln Tyr Leu Gly Arg Asn Asp Ala Gln Val Lys Ile 
    850                 855                 860                 


Asn Gly Leu Arg Ile Glu Pro Gly Glu Val Glu Ala Ala Leu Ala Gly 
865                 870                 875                 880 


Cys Ser Gly Val Arg Gln Cys Ala Val Val Ala Gly Ala Asp Pro Gln 
                885                 890                 895     


Ala Pro Glu Arg Lys Arg Leu Val Gly Tyr Tyr Leu Pro Glu Pro Gly 
            900                 905                 910         


Ala Ala Val Asp Glu Ala Asp Leu Phe Ala Ala Leu Arg Ala Gln Leu 
        915                 920                 925             


Met Pro Ser Met Val Pro Ser Leu Leu Val Arg Leu Asp Arg Pro Leu 
    930                 935                 940                 


Pro Met Thr Ile Thr Gly Lys Leu Asp Val Asp Ala Leu Pro Ser Ala 
945                 950                 955                 960 


Asp Phe Ser Pro Lys Arg Ala Ala Tyr Ala Ala Pro Arg Asp Arg Val 
                965                 970                 975     


Glu Ala Arg Leu Cys His Leu Trp Ser Ala Gln Leu Pro Gly Gly Thr 
            980                 985                 990         


Val Gly Ile Asp Asp Asp Phe Phe  Arg Cys Gly Gly Asp  Ser Ile Ser 
        995                 1000                 1005             


Ala Leu  His Leu Ala Ser Gln  Val Gln Arg Glu Ile  Glu Arg Lys 
    1010                 1015                 1020             


Val Ser  Val Lys Tyr Leu Phe  Asp His Pro Thr Val  Arg Ser Phe 
    1025                 1030                 1035             


Val Asp  Asn Val Leu Ser Gly  Leu Ala Glu Ser Ser  Gly Asp Asp 
    1040                 1045                 1050             


Glu Pro  Glu Gln Gly Arg Leu  Thr Gly Glu Cys Pro  Met Leu Pro 
    1055                 1060                 1065             


Ile Gln  Glu Trp Phe Phe Ala  Lys Pro Leu Ala Asp  Arg His Arg 
    1070                 1075                 1080             


Trp Asn  His Asn Phe Ala Ile  Arg Thr Pro Pro Leu  Asp Pro Gly 
    1085                 1090                 1095             


Glu Leu  Arg Thr Ala Leu Asp  Arg Leu Val Glu His  His Asp Ala 
    1100                 1105                 1110             


Phe Arg  Leu Arg Phe Pro Glu  Ser Gly Gly Gln Val  Tyr Ala Glu 
    1115                 1120                 1125             


Asp Ala  Ala Pro Ile Thr Leu  His Glu Leu Asp Val  Arg Gly Leu 
    1130                 1135                 1140             


Ala Asp  Ala Asp Leu Arg Gln  Arg Leu Val Asp Trp  Gln Arg Thr 
    1145                 1150                 1155             


Phe Asp  Leu Ala Asn Gly Pro  Thr Ala Cys Ala Ala  Tyr Leu His 
    1160                 1165                 1170             


Gly Phe  Asp Asp Gly Thr Ala  Arg Val Trp Phe Ala  Leu His His 
    1175                 1180                 1185             


Leu Val  Val Asp Thr Val Ser  Trp His Ile Leu Ala  Gln Asp Leu 
    1190                 1195                 1200             


Glu Ile  Leu Tyr Asn Gly Gly  Asp Leu Gly Ala Lys  Thr Gly Ser 
    1205                 1210                 1215             


Tyr Arg  Gln Trp Ala Gln Ala  Val Arg Asp Tyr Thr  Pro Ala Glu 
    1220                 1225                 1230             


Gly Glu  Arg Glu Phe Trp Ala  Glu Thr Thr Arg Asp  Met Glu Ser 
    1235                 1240                 1245             


Ala Glu  Leu Leu Ala Gln Thr  Glu Gly Thr Thr Arg  Arg Arg Glu 
    1250                 1255                 1260             


Glu Phe  Ala Leu Thr Ala Pro  Asp Thr Arg Thr Leu  Leu Ala Glu 
    1265                 1270                 1275             


Ser Pro  Trp Ala Tyr Asp Thr  Glu Val Asn Asp Leu  Leu Leu Thr 
    1280                 1285                 1290             


Ala Thr  Gly Ser Ala Leu Arg  Ser Ile Thr Arg Gln  Ala Thr Asn 
    1295                 1300                 1305             


His Leu  Thr Val Glu Gly His  Gly Arg Glu Leu Phe  Glu Gly Ala 
    1310                 1315                 1320             


Pro Asp  Val Arg Asp Thr Val  Gly Trp Phe Thr Thr  Met His Pro 
    1325                 1330                 1335             


Phe Ala  Val Glu Val Asp Pro  Gly Asp Leu Gly Arg  Ser Val Leu 
    1340                 1345                 1350             


Ala Thr  Arg Ala Asn Arg Arg  Arg Val Pro His His  Gly Ile Gly 
    1355                 1360                 1365             


Tyr Gly  Ala Leu Phe Gly Gly  Glu Ala Pro Leu Pro  Ala Val Ser 
    1370                 1375                 1380             


Phe Asn  Tyr Leu Gly Arg Leu  Gly Glu Gly Asp Gly  Gln Pro Thr 
    1385                 1390                 1395             


Glu Ala  Trp Gln Leu Asp Pro  Ala Leu Ser Gly Ser  His Thr Val 
    1400                 1405                 1410             


Asp Gly  Asn Arg Leu Ala Asn  Arg Ser Ser Ile Asp  Val Thr Met 
    1415                 1420                 1425             


Ser Cys  Thr Gly Gly Arg Leu  Val Ala Val Val Asp  Ser Leu Leu 
    1430                 1435                 1440             


Gly Glu  Ala Ala Thr Arg Leu  Phe Ala Ser Glu Leu  Lys Val Trp 
    1445                 1450                 1455             


Leu Glu  Arg Leu Val Ser His  Thr Ala Thr Val Ala  Arg Asn Glu 
    1460                 1465                 1470             


Pro Ala  Arg Glu Ala Thr Thr  Glu Leu Phe Asp Pro  Tyr Ile Leu 
    1475                 1480                 1485             


Val Asn  Glu Asp Ala Glu Arg  Thr Leu Phe Val Leu  Pro Pro Gly 
    1490                 1495                 1500             


Glu Gly  Gly Ala Glu Ser Tyr  Leu Ser Asn Leu Ala  Arg Gln Leu 
    1505                 1510                 1515             


Pro Asp  Leu Arg Leu Val Leu  Phe Asn Asn Val His  Leu His Thr 
    1520                 1525                 1530             


Pro Met  Gly Ser Phe Glu Glu  Leu Gly Arg Tyr Tyr  Val Glu His 
    1535                 1540                 1545             


Ile Arg  Arg Leu Gln Pro Ser  Gly Pro Tyr His Leu  Leu Gly Trp 
    1550                 1555                 1560             


Ser Phe  Gly Gly Val Leu Ser  Leu Glu Ile Ser Arg  Gln Leu Ala 
    1565                 1570                 1575             


Arg Ala  Gly Glu Arg Ile Asp  Asp Leu Leu Leu Ile  Asp Pro Tyr 
    1580                 1585                 1590             


Phe Gly  Met Arg Gln Ala Ser  Ala Asn Ile Gly Leu  Pro Gly Val 
    1595                 1600                 1605             


Glu Asp  Ile Leu Asp Pro Ile  Asn Tyr His Tyr Arg  Pro Asp Glu 
    1610                 1615                 1620             


Ala Asp  Leu Ala Arg Leu Ala  Gly Arg Leu Gly Asn  Leu Val Leu 
    1625                 1630                 1635             


Phe Lys  Ala Gly Glu Pro Asn  Asp Val Val Asn Gly  Pro His Gln 
    1640                 1645                 1650             


Pro Arg  Leu Phe Glu Tyr Tyr  His Gly Thr Arg Phe  Asn His Leu 
    1655                 1660                 1665             


Asp Leu  Leu Leu Pro Ala Ala  Ala Ile Glu Val Cys  Asp Leu Ala 
    1670                 1675                 1680             


Gly Glu  Thr His His Ser Trp  Val Arg Asn Glu Lys  Leu Val Arg 
    1685                 1690                 1695             


Leu Met  Cys Glu Arg Ile Ser  Thr 
    1700                 1705     


<210>  11
<211>  5120
<212>  DNA
<213>  Nocardia lactamdurans

<400>  11
cgagcacacc gcgtggacgc cgccgcccac cgcggtcgag cacccgccgg tctcgctggc     60

gcaggaacgc ctgctgttca tcgacgactt cgaaggcggc acggcggcct acaacatccc    120

gttcgtgctc cggctgcccg cgcacacccg tgccgcgctc cccggtgcgc tgggcacgct    180

cgtgcgccgc cacccggccc tgcgcacgct gctgaagacc gacgaccagg gcgtgcggcg    240

gcagtacccg atcccggcgg acgacgtccg gctcgaggtc ccgtcgacca cagtggacag    300

ccgggccgag ctggacgagg tgctgaccga gcgcgccggg tacgtgttcc ggctgcacga    360

ggaactgccc atccgcgccg aagcgttcga ccacggcgac gagatctacc tcagcgtcgt    420

ggtgcaccac agctgcttcg acggctggtc gtgggacatc ttccgccgcg agctggcggc    480

cctgctcgac ggcgtccccg aagccgatct cggcgcgctg cgcggcacct acggcgagtt    540

cgcggtgtgg cagcggcagt acctgaccgg caagcggctg gccgcgctga ccgagttctg    600

gaccggcgcg ctcggcggct tcgagaccat cgccctgccg ctggaccacc cgcgcccgcc    660

gcggttcgac taccgcggcc gcgagctgga gttcgagctg gacgagcgga ccaccgaggc    720

gctgcgcgag ctggccagga ccgccagggt gagcctctac agcgtgctgc tcggcgcctg    780

gtgcctgatg ctcaacatgt acaccgggca gcacgacctc gtggtcggca cgccgtcggc    840

gaaccgcggc cgcccggagt tcgacagggc ggtcggcttc ttcgcgaacc tgctcgccct    900

gcgggtccgc gtcgacccgg ccgcgaccct gccggcctac gtccggtcgg tcggcgaggc    960

ggtggtggcc gcgcaggtgc acggcgagct gccgttcgag cagctggtca aggaactcaa   1020

ggtggagaag gacccgagcc gtcacccgat cctgcagctc aacttcaccc tgcagaacgt   1080

ctccgaccac accagcgcgc tgaccgggta ccagccggac agcggtggct ggaccaccac   1140

caagttcgac ctgtccgcga cgatgaccga gaccgcgacc gggctggccg gcaacctgac   1200

ctacgccgcg tccctgttcg acgacaccag cgcgagcggg ttcatcgcca ccttcaagca   1260

cgtgctggcc gagttcgcct cggccgccgc gcagaccccg atcgcccagc tcaccgcgct   1320

cgacgagccg gggcaggcgg cgctgctgac gccacccgcc gagcccgccg cccggcggac   1380

ccggacgctg cacgcggtct tcgaggaggt ggcggcgacc tggccggacc gggtcgccgt   1440

ggtccacggt gacgtgcggc tgacctaccg cgaattgaac gagcgggcca accgcctcgc   1500

ccaccacctg cggtcggtgg ccgaaccgcg ggccgacgag ctgatcgcgc tggtgctgga   1560

caagtccgag ctgaccctcg tggcgatcct cgcggtgtgg aaggccgggg cggcgtacat   1620

gccgatcgat ccgagctacc ccgacgaccg gatcgcgttc atgctgtccg acaccggcgc   1680

gaaactggtg ctcgccgggg aagcacacgg ctcgcgggtg cgcggcctga cctcgggcga   1740

cgtgctcgac ctcgaacagc tcgacctgac cggcgaaccc gcggagaacc cggtcaccga   1800

gaccaccagc accgaactgg cctacgcgat ctacacctcc ggcaccaccg gcaagcccaa   1860

ggcggtgctc gtctcgcacg gctcggtcga cagcttccgc gcgcagctga gcgggcgcta   1920

cttcggctcg ccggacgagt ccgccgaagc cgtgttgttc ctggcgaact acgtgttcga   1980

cttctccgtc gagcaactgg cgctgtcggt gctcggcggg cacaagctgc tcgtgccgcc   2040

gccctcggcc gccgacgatc cggcgttcta cgagctggcg aaccgcgagg gtctgagcta   2100

cctcagcggt actccgacgc aggtggagcg cttcgacctg gcgcacctga gccacctgcg   2160

gtgcgtgctg gtcgccggtg aggcgttcca gccgcagcac ttcgagaaga tgcgcggcga   2220

gttcgccggg ccgatcctca acgcctacgg caccaccgaa accaccgtgt acaacaccgt   2280

gcaccgcttc gagcccggtg acgcctaccg gaacaccctc ggcgcgccgc tgggcaacac   2340

ccggctctac gtgctcggcg acgggatgaa gctgctgccc acgggcgcgg tcggcgagct   2400

gtacctggcg ggcgactgcg tgaccgaggg gtacctgcac cggcccgagc tgacccgcga   2460

gcggttcctg ccgaacccgt tcgcggcgga atccggccgg ttcccgatga tctaccgcac   2520

cggggacgtg gtccgccgcg gcccggacgg cgaactccag tacctgggcc gcaacgacgc   2580

ccaggtgaag atcaacggcc tgcggatcga gcccggcgag gtcgaagcgg cactggccgg   2640

ctgttccggc gtgcgccagt gcgcggtcgt cgcgggcgcg gacccgcagg cacccgagcg   2700

caaacggctc gtcggctact acctgcccga gcccggcgcg gccgtggacg aagccgacct   2760

cttcgccgcg ctgcgggcgc agctgatgcc gagcatggtg ccctcgctgc tggtgcggct   2820

cgatcgcccg ctgccgatga cgatcaccgg caagctggac gtggatgcct tgcccagcgc   2880

ggacttctcc ccgaagcggg cggcctacgc ggcccctcgt gaccgggtgg aagcgcggct   2940

gtgccacctg tggagcgcgc agctgccggg cggcacggtc ggcatcgacg acgacttctt   3000

ccgctgcggt ggcgacagca tcagcgcgct gcacctggcg agccaggtgc agcgggagat   3060

cgagcgcaag gtcagcgtca agtacctctt cgaccacccg accgtgcggt ccttcgtgga   3120

caacgtgctc tccggcctcg ccgagagctc cggcgacgac gaacccgagc agggcaggct   3180

gaccggcgag tgcccgatgc tgcccatcca ggagtggttc ttcgccaagc cgctggccga   3240

ccggcaccgc tggaaccaca acttcgccat ccggaccccg ccgctggacc ccggcgagct   3300

gcggaccgcg ctggaccggc tggtcgagca ccacgacgcc ttccggctgc ggttcccgga   3360

aagcggcggg caggtctacg ccgaggacgc cgcgccgatc accctgcacg agctcgacgt   3420

gcgcggcctg gccgacgccg acctgcggca gcgcctggtc gactggcagc gcaccttcga   3480

cctggcgaac gggccgacgg cctgtgcggc ctacctgcac gggttcgacg acggcaccgc   3540

acgggtctgg ttcgccctgc accacctcgt ggtggacacg gtgagctggc acatcctcgc   3600

ccaggacctg gaaatcctgt acaacggcgg cgacctgggc gcgaagaccg gcagctaccg   3660

gcagtgggcc caggcggtgc gcgactacac cccggccgag ggggagcgcg agttctgggc   3720

ggagaccacc cgggacatgg agtccgcgga actgctggcg cagaccgaag gcaccaccag   3780

gcgccgcgag gagttcgcgc tcaccgcccc ggacacgcgg acgctgctgg cggagagccc   3840

gtgggcctac gacaccgagg tcaacgacct gctgctgacc gcgaccggct ccgcgctgcg   3900

gtcgatcacc cggcaggcga cgaaccacct caccgtcgag ggccacggcc gcgagctgtt   3960

cgagggcgcg ccggacgtgc gggacaccgt cggctggttc accaccatgc acccgttcgc   4020

cgtcgaggtg gatcccggcg acctcgggcg cagcgtgctc gccaccaggg cgaaccggcg   4080

ccgggtgccg caccacggca tcggctacgg cgcgctcttc ggcggtgagg ccccgctgcc   4140

ggcggtcagc ttcaactacc tcggcaggct gggcgagggg gacgggcagc cgaccgaggc   4200

gtggcagctc gacccggcgt tgtccggcag ccacaccgtc gacggcaacc gcctggcgaa   4260

ccggtccagc atcgacgtga cgatgagctg caccggcggc cgcctggtcg cggtggtgga   4320

cagcctgctc ggcgaagcgg ccacgcgcct gttcgccagc gagctgaagg tgtggctgga   4380

gcggctggtc tcgcacaccg cgaccgtcgc ccgcaacgaa ccggcacgcg aagccaccac   4440

cgagctgttc gacccgtaca tcctggtcaa cgaggacgcc gagcgcacgc tcttcgtgct   4500

gccgccgggc gaaggcggcg cggagagcta cctgagcaac ctcgcgcggc agttaccgga   4560

cctgcggctc gtgctgttca acaacgtcca cctgcacacg cccatgggct cgttcgagga   4620

actggggcgc tactacgtcg agcacatccg gcggctgcag ccgtccgggc cgtaccacct   4680

gctcggctgg agcttcggcg gcgtgctgtc gctggagatc tcccggcagc tcgcgcgggc   4740

gggggagcgg atcgacgacc tgctgctgat cgacccgtac ttcgggatgc ggcaggcctc   4800

ggcgaacatc gggctgcccg gggtcgagga catcctcgac ccgatcaact accactaccg   4860

cccggacgag gccgacctcg cgcggctggc cgggcggctc gggaacctgg tgctgttcaa   4920

ggccggtgag ccgaacgacg tggtgaacgg cccgcaccag ccccggttgt tcgagtacta   4980

ccacgggacg cgcttcaacc acctcgacct gctgctgccc gcggccgcga tcgaggtctg   5040

cgacctggcc ggggagacgc accactcgtg ggtgcgcaac gagaagctgg tgcggctgat   5100

gtgcgagcgg atttcgacga                                               5120


<210>  12
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  12
caccatggcg acgctgccgg aactgttc                                        28


<210>  13
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  13
tcaattaatt aaccactcgg actcaaggtc ggac                                 34


<210>  14
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  14
caccttaatt aatgaggaga atgcagcaac ggac                                 34


<210>  15
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  15
tcaatagcga gcgaggtgtt c                                               21


<210>  16
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  16
caccactagt ctggagtatc tctcatctat c                                    31


<210>  17
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  17
caccttaatt aatgccgaag aggtcaccac c                                    31


<210>  18
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  18
ggtcatcgct ccctagg                                                    17


<210>  19
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  19
caccactagt ctcatctcac cgtcgatg                                        28


<210>  20
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  20
caccttaatt aatagccagc aaccgacccg tgcg                                 34


<210>  21
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  21
ttactagtgt cgcgggcgta cgcctcgtc                                       29


<210>  22
<211>  1531
<212>  DNA
<213>  Artificial

<220>
<223>  Hybrid sequence

<400>  22
ggttaattaa tatcgaacat tgcgcagctc aagaacacat tcacctgacg ccaagcgata     60

tttcgctgaa ggacataaca atcgaggaat tagatcaatt tgttaagcaa acacagcata    120

tcggcgacat tgaaaatata tatcctttaa ctcccatgca gaaaggtatg ctgttccata    180

gtttaatcga ttcggcttcc agagcttact ttgaacaagc cgcttttgac ctcaaaggcg    240

acttggatat tgaggcattt acaatgagtt tgtcgtatct ggcggaaagc catgagattc    300

tccggactca tttttatacg gaatggaaag atcagccttt gcagatcgta ttccgaaaaa    360

aaccgatcga aataaccgtt gaagatattc gaagcatgaa gaataaacaa cgaaacgagt    420

tcattgccgg ctttgtacaa aaagataagg caagaggatt cgaccttacc caagatgcgt    480

taatgcgcgt atcaatcctt cgtacagagg acgaccaagt ccgattgata tggagcttcc    540

atcatatttt aatggatggc tggtgtctgc ctcttattac gaaagaagtg tttgaaacct    600

attatgagct tcttgagaga agacaaccgg agcgggaagc cgtcaccccg tacagccgat    660

atatcgaatg gctggaagac caggatcatc agaacgcttt ggcctattgg caaaaatatt    720

tggacggtta tgaaggacaa accgttttac tgaaagaacc tgtctcaaac caagccaagg    780

gatatcaaaa acaaaggctt gcatgccggc tcggaaagca gctatcagaa gaaatcagac    840

agactgcaag caagcatcac gtcaccgtga atacattcat tcaaagtgcg tgggggctat    900

tgctgcaaag atacaacaac agtcaggatg tcgttttcgg gtcggttgta tccggacgcc    960

cggcagaaat tccgggtatt gaatccatgg tcggcttatt tatcaacacc attcccgtac   1020

gtattaccgc tcagcctgga atgactgtgg aacaagtgtt gaaaatgagc caggagcagg   1080

cattggcttc tcaggcgtat gatacatttc cgttgtatga aattcaggct caaaccgaac   1140

aaaagcagca gctgatcagt catatcatgg tatttgaaaa ttatccggtc gagaaacaaa   1200

tggagcatat gaaaccgaat cgtgacgcgc tggacattat caatttccat atggaagagc   1260

atacccatta cgatttcaat ttcattgtca tgccggctgg agaaatcgac attcattttg   1320

tatacaatag caacgtctat gatcatgcaa gtgtcaagcg gatggaagag cattttatgc   1380

aaatcattaa gcagatggtg aacagtcagg cgattcgcgt ccaagacttg gatatactta   1440

cgggagatga acgttcgctc cttatagagg catttaatga tacggaagca gattatccaa   1500

aggaaaagac gcttcatcaa ttgactagta a                                  1531


<210>  23
<211>  1909
<212>  DNA
<213>  Artificial

<220>
<223>  Hybrid sequence


<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (175)..(175)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (383)..(383)
<223>  n is a, c, g, or t

<400>  23
tcgagcggcc ggcgtattgg gtgttacgga gcattcacta ggcaaccatg catggttact     60

attgtatacc atcttagtag gaantgattt cgaggtttat acctacgatg aatgtgtgtc    120

ctgtaggctt gagagttcaa ggaagaaaca tgcaattatc tttgcgaacc caggngctgg    180

tgacggaatt ttcatagtca agctatcaga gtaaagaaga ggagcatgtc aaagtacaat    240

tagagacaaa tatatagtcg cgtggagcca agagcggatt cctcagtctc gtaggtctct    300

tgacgaccgt tgatctgctt gatctcgtct cccgaaaatg aaaatagctc tgctaagcta    360

ttcttctctt cgccggagcc tgnaaggcgt tactaggttg cagtcaatgc attaatgcat    420

tgcagatgag ctgtatctgg aagaggtaaa cccgaaaacg cgttttattc ttgttgacat    480

ggagctatta aatcactaga aggcactctt tgctgcttgg acaaatgaac gtatcttatc    540

gagatcctga acaccatttg tctcaactcc ggagctgaca tcgacaccaa cgatcttata    600

tccagattcg tcaagctgtt tgatgatttc agtaacgtta agtggatctc aagctcctgg    660

gacccgtggg ccgccgtcgg accggcggtg ttggtcggcg tcggtcagtc ctgctcctcg    720

gccacgaagt gcacgcagtt gccggccggg tcgcgcaggg cgaactcccg cccccacggc    780

tgctcgccga tctcggtcat ggccggcccg gaggcgtccc ggaagttcgt ggacacgacc    840

tccgaccact cggcgtacag ctcgtccagg ccgcgcaccc acacccaggc cagggtgttg    900

tccggcacca cctggtcctg gaccgcgctg atgaacaggg tcacgtcgtc ccggaccaca    960

ccggcgaagt cgtcctccac gaagtcccgg gagaacccga gccggtcggt ccagaactcg   1020

accgctccgg cgacgtcgcg cgcggtgagc accggaacgg cactggtcaa cttggccatg   1080

gtgatgtctg ctcaagcggg gtagctgtta gtcaagctgc gatgaagtgg gaaagctcga   1140

actgaaaggt tcaaaggaat aagggatggg aaggatggag tatggatgta gcaaagtact   1200

tacttagggg aaataaaggt tcttggatgg gaagatgaat atactgaaga tgggaaaaga   1260

aagagaaaag aaaagagcag ctggtgggga gagcaggaaa atatggcaac aaatgttgga   1320

ctgacgcaac gaccttgtca accccgccga cacaccgggc ggacagacgg ggcaaagctg   1380

cctaccaggg actgagggac ctcagcaggt cgagtgcaga gcaccggatg ggtcgactgc   1440

cagcttgtgt tcccggtctg cgccgctggc cagctcctga gcggcctttc cggtttcata   1500

caccgggcaa agcaggagag gcacgatatt tggacgccct acagatgccg gatgggccaa   1560

ttagggagct tacgcgccgg gtactcgctc tacctacttc ggagaaggta ctatctcgtg   1620

aatcttttac cagatcggaa gcaattggac ttctgtacct aggttaatgg catgctattt   1680

cgccgacggc tatacacccc tggcttcaca ttctccttcg cttactgccg gtgattcgat   1740

gaagctccat attctccgat gatgcaatag attcttggtc aacgaggggc acaccagcct   1800

ttccacttcg gggcggaggg gcggccggtc ccggattaat aatcatccac tgcacctcag   1860

agccgccaga gctgtctgga agcttctgca gacgcgtcga cgtcatatg               1909


<210>  24
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  24
ttatcgattt gcataaaaaa cagac                                           25


<210>  25
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  25
ttatcgatgc ttaccttcaa gcttcg                                          26


<210>  26
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  26
gcctggtgcc tgatgc                                                     16


<210>  27
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  27
ggtgtggtcg gagacg                                                     16


<210>  28
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  28
caggaggaat tacatatgca gaatttcgag                                      30


<210>  29
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  29
cggccaggga tgcatacgtc atcgccgagc                                      30


<210>  30
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  30
caggaggaat tacatatgcc gcccagtgac                                      30


<210>  31
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  31
gaattcccat atgcatccag gtcatcggcc                                      30


<210>  32
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  32
caggaggaat tacatatgac caccaccacc                                      30


<210>  33
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  33
tcccatatgc atcctcaacc gttagacgcc                                      30


<210>  34
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  34
gtgaggtaac atatgagcca gaatctcttt                                      30


<210>  35
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  35
gtaatcaatg catcactcat gcgtgtgttc                                      30


<210>  36
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  36
caggaggaat tacatatgtc tatttatagc                                      30


<210>  37
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  37
gtcctcggtc tcatgcatct cgagttagcc caggaggt                             38


