
                                SEQUENCE LISTING

<110> CENTOCOR, INC.

<120> METHOD FOR DETECTING IL-16 ACTIVITY AND MODULATION OF IL-16                  ACTIVITY BASED ON PHOSPHORYLATED STAT-6 PROXY LEVELS

<130> CEN5152PCT

<140> TO BE ASSIGNED      
<141> 2007-09-24

<150> 60/827313
<151> 2006-09-28 

<160> 4

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 433
<212> PRT
<213> Homo sapiens

<400> 1
Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys
 1               5                  10                  15      
Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn
            20                  25                  30          
Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro
        35                  40                  45              
Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln
    50                  55                  60                  
Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp
65                  70                  75                  80  
Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu
                85                  90                  95      
Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln
            100                 105                 110         
Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val
        115                 120                 125             
Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu
    130                 135                 140                 
Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr
145                 150                 155                 160 
Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val
                165                 170                 175     
Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu
            180                 185                 190         
Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr
        195                 200                 205             
Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys
    210                 215                 220                 
Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg
225                 230                 235                 240 
Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His
                245                 250                 255     
Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu
            260                 265                 270         

Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn
        275                 280                 285             
Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu
    290                 295                 300                 
Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu
305                 310                 315                 320 
Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu
                325                 330                 335     
Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln
            340                 345                 350         
Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro
        355                 360                 365             
Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu
    370                 375                 380                 
Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg
385                 390                 395                 400 
Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu
                405                 410                 415     
Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro
            420                 425                 430         
Ile
    


<210> 2
<211> 228
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly
 1               5                  10                  15      
Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly
            20                  25                  30          
Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu
        35                  40                  45              
Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile
    50                  55                  60                  
Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly
65                  70                  75                  80  
Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu
                85                  90                  95      
Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser
            100                 105                 110         
His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr
        115                 120                 125             
Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys
    130                 135                 140                 
Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu
145                 150                 155                 160 
Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe
                165                 170                 175     
Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys
            180                 185                 190         
Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile
        195                 200                 205             
Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn
    210                 215                 220                 
Arg Glu Met Val
225             


<210> 3
<211> 121
<212> PRT
<213> Homo sapiens

<400> 3
Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr
 1               5                  10                  15      
Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly
            20                  25                  30          
Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys
        35                  40                  45              
Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser
    50                  55                  60                  
Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala
65                  70                  75                  80  
Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu
                85                  90                  95      
Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser
            100                 105                 110         
Lys Glu Thr Thr Ala Ala Gly Asp Ser
        115                 120     


<210> 4
<211> 846
<212> PRT
<213> Homo sapiens

<400> 4
Ser Leu Trp Gly Leu Val Ser Lys Met Pro Pro Glu Lys Val Gln Arg
 1               5                  10                  15      
Leu Tyr Val Asp Phe Pro Gln His Leu Arg His Leu Leu Gly Asp Trp
            20                  25                  30          
Leu Glu Ser Gln Pro Trp Glu Phe Leu Val Gly Ser Asp Ala Phe Cys
        35                  40                  45              
Cys Asn Leu Ala Ser Ala Leu Leu Ser Asp Thr Val Gln His Leu Gln
    50                  55                  60                  
Ala Ser Val Gly Glu Gln Gly Glu Gly Ser Thr Ile Leu Gln His Ile
65                  70                  75                  80  
Ser Thr Leu Glu Ser Ile Tyr Gln Arg Asp Pro Leu Lys Leu Val Ala
                85                  90                  95      
Thr Phe Arg Gln Ile Leu Gln Gly Glu Lys Lys Ala Val Met Glu Gln
            100                 105                 110         
Phe Arg His Leu Pro Met Pro Phe His Trp Lys Gln Glu Glu Leu Lys
        115                 120                 125             
Phe Lys Thr Gly Leu Arg Arg Leu Gln His Arg Val Gly Glu Ile His
    130                 135                 140                 
Leu Leu Arg Glu Ala Leu Gln Lys Gly Ala Glu Ala Gly Gln Val Ser
145                 150                 155                 160 
Leu His Ser Leu Ile Glu Thr Pro Ala Asn Gly Thr Gly Pro Ser Glu
                165                 170                 175     
Ala Leu Ala Met Leu Leu Gln Glu Thr Thr Gly Glu Leu Glu Ala Ala
            180                 185                 190         
Lys Ala Leu Val Leu Lys Arg Ile Gln Ile Trp Lys Arg Gln Gln Gln
        195                 200                 205             
Leu Ala Gly Asn Gly Ala Pro Phe Glu Glu Ser Leu Ala Pro Leu Gln
    210                 215                 220                 
Glu Arg Cys Glu Ser Leu Val Asp Ile Tyr Ser Gln Leu Gln Gln Glu
225                 230                 235                 240 
Val Gly Ala Ala Gly Gly Glu Leu Glu Pro Lys Thr Arg Ala Ser Leu
                245                 250                 255     
Thr Gly Arg Leu Asp Glu Val Leu Arg Thr Leu Val Thr Ser Cys Phe
            260                 265                 270         
Leu Val Glu Lys Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe
        275                 280                 285             
Gln Ala Gly Val Arg Phe Leu Leu Gly Leu Arg Phe Leu Gly Ala Pro
    290                 295                 300                 
Ala Lys Pro Pro Leu Val Arg Ala Asp Met Val Thr Glu Lys Gln Ala
305                 310                 315                 320 
Arg Glu Leu Ser Val Pro Gln Gly Pro Gly Ala Gly Ala Glu Ser Thr
                325                 330                 335     
Gly Glu Ile Ile Asn Asn Thr Val Pro Leu Glu Asn Ser Ile Pro Gly
            340                 345                 350         
Asn Cys Cys Ser Ala Leu Phe Lys Asn Leu Leu Leu Lys Lys Ile Lys
        355                 360                 365             
Arg Cys Glu Arg Lys Gly Thr Glu Ser Val Thr Glu Glu Lys Cys Ala
    370                 375                 380                 
Val Leu Phe Ser Ala Ser Phe Thr Leu Gly Pro Gly Lys Leu Pro Ile
385                 390                 395                 400 
Gln Leu Gln Ala Leu Ser Leu Pro Leu Val Val Ile Val His Gly Asn
                405                 410                 415     
Gln Asp Asn Asn Ala Lys Ala Thr Ile Leu Trp Asp Asn Ala Phe Ser
            420                 425                 430         
Glu Met Asp Arg Val Pro Phe Val Val Ala Glu Arg Val Pro Trp Glu
        435                 440                 445             
Lys Met Cys Glu Thr Leu Asn Leu Lys Phe Met Ala Glu Val Gly Thr
    450                 455                 460                 
Asn Arg Gly Leu Leu Pro Glu His Phe Leu Phe Leu Ala Gln Lys Ile
465                 470                 475                 480 
Phe Asn Asp Asn Ser Leu Ser Met Glu Ala Phe Gln His Arg Ser Val
                485                 490                 495     
Ser Trp Ser Gln Phe Asn Lys Glu Ile Leu Leu Gly Arg Gly Phe Thr
            500                 505                 510         
Phe Trp Gln Trp Phe Asp Gly Val Leu Asp Leu Thr Lys Arg Cys Leu
        515                 520                 525             
Arg Ser Tyr Trp Ser Asp Arg Leu Ile Ile Gly Phe Ile Ser Lys Gln
    530                 535                 540                 
Tyr Val Thr Ser Leu Leu Leu Asn Glu Pro Asp Gly Thr Phe Leu Leu
545                 550                 555                 560 
Arg Phe Ser Asp Ser Glu Ile Gly Gly Ile Thr Ile Ala His Val Ile
                565                 570                 575     
Arg Gly Gln Asp Gly Ser Pro Gln Ile Glu Asn Ile Gln Pro Phe Ser
            580                 585                 590         
Ala Lys Asp Leu Ser Ile Arg Ser Leu Gly Asp Arg Ile Arg Asp Leu
        595                 600                 605             
Ala Gln Leu Lys Asn Leu Tyr Pro Lys Lys Pro Lys Asp Glu Ala Phe
    610                 615                 620                 
Arg Ser His Tyr Lys Pro Glu Gln Met Gly Lys Asp Gly Arg Gly Tyr
625                 630                 635                 640 
Val Pro Ala Thr Ile Lys Met Thr Val Glu Arg Asp Gln Pro Leu Pro
                645                 650                 655     
Thr Pro Glu Leu Gln Met Pro Thr Met Val Pro Ser Tyr Asp Leu Gly
            660                 665                 670         
Met Ala Pro Asp Ser Ser Met Ser Met Gln Leu Gly Pro Asp Met Val
        675                 680                 685             
Pro Gln Val Tyr Pro Pro His Ser His Ser Ile Pro Pro Tyr Gln Gly
    690                 695                 700                 
Leu Ser Pro Glu Glu Ser Val Asn Val Leu Ser Ala Phe Gln Glu Pro
705                 710                 715                 720 

His Leu Gln Met Pro Pro Ser Leu Gly Gln Met Ser Leu Pro Phe Asp
                725                 730                 735     
Gln Pro His Pro Gln Gly Leu Leu Pro Cys Gln Pro Gln Glu His Ala
            740                 745                 750         
Val Ser Ser Pro Asp Pro Leu Leu Cys Ser Asp Val Thr Met Val Glu
        755                 760                 765             
Asp Ser Cys Leu Ser Gln Pro Val Thr Ala Phe Pro Gln Gly Thr Trp
    770                 775                 780                 
Ile Gly Glu Asp Ile Phe Pro Pro Leu Leu Pro Pro Thr Glu Gln Asp
785                 790                 795                 800 
Leu Thr Lys Leu Leu Leu Glu Gly Gln Gly Glu Ser Gly Gly Gly Ser
                805                 810                 815     
Leu Gly Ala Gln Pro Leu Leu Gln Pro Ser His Tyr Gly Gln Ser Gly
            820                 825                 830         
Ile Ser Met Ser His Met Asp Leu Arg Ala Asn Pro Ser Trp
        835                 840                 845     


