                         SEQUENCE LISTING

<110>  VIB vzw
       D. Collen Research Foundation
 
<120>  Means and methods for the stimulation of skeletal muscle 
       regeneration

<130>  PCA/Cri/V247

<150>  EP 06120124.0
<151>  2006-09-05

<150>  EP 07103231.2
<151>  2007-02-28

<160>  19    

<170>  PatentIn version 3.3

<210>  1
<211>  2033
<212>  DNA
<213>  Homo sapiens

<400>  1
ggagaatccc cggaaaggct gagtctccag ctcaaggtca aaacgtccaa ggccgaaagc     60

cctccagttt cccctggacg ccttgctcct gcttctgcta cgaccttctg gggaaaacga    120

atttctcatt ttcttcttaa attgccattt tcgctttagg agatgaatgt tttcctttgg    180

ctgttttggc aatgactctg aattaaagcg atgctaacgc ctcttttccc cctaattgtt    240

aaaagctatg gactgcagga agatggcccg cttctcttac agtgtgattt ggatcatggc    300

catttctaaa gtctttgaac tgggattagt tgccgggctg ggccatcagg aatttgctcg    360

tccatctcgg ggatacctgg ccttcagaga tgacagcatt tggccccagg aggagcctgc    420

aattcggcct cggtcttccc agcgtgtgcc gcccatgggg atacagcaca gtaaggagct    480

aaacagaacc tgctgcctga atgggggaac ctgcatgctg gggtcctttt gtgcctgccc    540

tccctccttc tacggacgga actgtgagca cgatgtgcgc aaagagaact gtgggtctgt    600

gccccatgac acctggctgc ccaagaagtg ttccctgtgt aaatgctggc acggtcagct    660

ccgctgcttt cctcaggcat ttctacccgg ctgtgatggc cttgtgatgg atgagcacct    720

cgtggcttcc aggactccag aactaccacc gtctgcacgt actaccactt ttatgctagt    780

tggcatctgc ctttctatac aaagctacta ttaatcgaca ttgacctatt tccagaaata    840

caattttaga tatcatgcaa atttcatgac cagtaaaggc tgctgctaca atgtcctaac    900

tgaaagatga tcatttgtag ttgccttaaa ataatgaata caatttccaa aatggtctct    960

aacatttcct tacagaacta cttcttactt ctttgccctg ccctctccca aaaaactact   1020

tcttttttca aaagaaagtc agccatatct ccattgtgcc taagtccagt gtttcttttt   1080

tttttttttt ttgagacgga gtctcactct gtcacccagg ctggactgca atgacgcgat   1140

cttggttcac tgcaacctcc gcatccgggg ttcaagccat tctcctgcct aagcctccca   1200

agtaactggg attacaggca tgtgtcacca tgcccagcta atttttttgt attttagtag   1260

agatgggggt ttcaccatat tggccagtct ggtctcgaac tctgaccttg tgatccatcg   1320

atcagcctct cgagtgctga gattacacac gtgagcaact gtgcaaggcc tggtgtttct   1380

tgatacatgt aattctacca aggtcttctt aatatgttct tttaaatgat tgaattatat   1440

gttcagatta ttggagacta attctaatgt ggaccttaga atacagtttt gagtagagtt   1500

gatcaaaatc aattaaaata gtctctttaa aaggaaagaa aacatcttta aggggaggaa   1560

ccagagtgct gaaggaatgg aagtccatct gcgtgtgtgc agggagactg ggtaggaaag   1620

aggaagcaaa tagaagagag aggttgaaaa acaaaatggg ttacttgatt ggtgattagg   1680

tggtggtaga gaagcaagta aaaaggctaa atggaagggc aagtttccat catctataga   1740

aagctatata agacaagaac tccccttttt ttcccaaagg cattataaaa agaatgaagc   1800

ctccttagaa aaaaaattat acctcaatgt ccccaacaag attgcttaat aaattgtgtt   1860

tcctccaagc tattcaattc ttttaactgt tgtagaagac aaaatgttca caatatattt   1920

agttgtaaac caagtgatca aactacatat tgtaaagccc atttttaaaa tacattgtat   1980

atatgtgtat gcacagtaaa aatggaaact atattgacct aaaaaaaaaa aaa          2033


<210>  2
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Cys Arg Lys Met Ala Arg Phe Ser Tyr Ser Val Ile Trp Ile 
1               5                   10                  15      


Met Ala Ile Ser Lys Val Phe Glu Leu Gly Leu Val Ala Gly Leu Gly 
            20                  25                  30          


His Gln Glu Phe Ala Arg Pro Ser Arg Gly Tyr Leu Ala Phe Arg Asp 
        35                  40                  45              


Asp Ser Ile Trp Pro Gln Glu Glu Pro Ala Ile Arg Pro Arg Ser Ser 
    50                  55                  60                  


Gln Arg Val Pro Pro Met Gly Ile Gln His Ser Lys Glu Leu Asn Arg 
65                  70                  75                  80  


Thr Cys Cys Leu Asn Gly Gly Thr Cys Met Leu Gly Ser Phe Cys Ala 
                85                  90                  95      


Cys Pro Pro Ser Phe Tyr Gly Arg Asn Cys Glu His Asp Val Arg Lys 
            100                 105                 110         


Glu Asn Cys Gly Ser Val Pro His Asp Thr Trp Leu Pro Lys Lys Cys 
        115                 120                 125             


Ser Leu Cys Lys Cys Trp His Gly Gln Leu Arg Cys Phe Pro Gln Ala 
    130                 135                 140                 


Phe Leu Pro Gly Cys Asp Gly Leu Val Met Asp Glu His Leu Val Ala 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Leu Pro Pro Ser Ala Arg Thr Thr Thr Phe Met 
                165                 170                 175     


Leu Val Gly Ile Cys Leu Ser Ile Gln Ser Tyr Tyr 
            180                 185             


<210>  3
<211>  2026
<212>  DNA
<213>  Homo sapiens

<400>  3
ggagaatccc cggaaaggct gagtctccag ctcaaggtca aaacgtccaa ggccgaaagc     60

cctccagttt cccctggaca ccttgctcct gcttctgcta cgaccttctg gggaacgcga    120

atttctcatt ttcttcttaa attgccattt tcgctttagg agatgaatgt tttcctttgg    180

ctgttttggc aatgactctg aattaaagcg atgctaacgc ctcttttccc cctaattgtt    240

aaaagctatg gactgcagga agatggtccg cttctcttac agtgtgattt ggatcatggc    300

catttctaaa gcctttgaac tgggattagt tgccgggctg ggccatcagg aatttgctcg    360

tccatctcgg ggagacctgg ccttcagaga tgacagcatt tggccccagg aggagcctgc    420

aattcggcct cggtcttccc agcgtgtgct gcccatggga atacagcaca gtaaggagct    480

aaacagaacc tgctgcctga atgggggaac ctgcatgctg gagtcctttt gtgcctgccc    540

tccctccttc tacggacgga actgtgagca cgatgtgcgc aaagagaact gtgggtctgt    600

gccccatgac acctggctgc ccaagaagtg ttccctgtgt aaatgctggc acggtcagct    660

ccgctgcttt cctcaggcat ttctacccgg ctgtgatggc cttgtgatgg atgagcacct    720

cgtggcttcc aggactccag aactaccacc gtctgcacgt actaccactt ttatgctagc    780

tggcatctgc ctttctatac aaagctacta ttaatcgaca ttgacctatt tccagaaata    840

caattttaga tattatgcaa atttcatgac ccgtaaaggc tgctgctaca atgtcctaac    900

tgaaagatga tcatttgtta gttgccttaa aataatgaat acatttccaa aacggtctct    960

aacatttcct tacagaacta actacttctt acctctttgc cctgccctct cccaaaaaac   1020

tacttctttt ttcaaaagaa agtcagccat atctccattg tgcccaagtc cagtgtttct   1080

tttttttttt tgagacggag tctcactctg tcacccaggc tggactgcaa tgacgcgatc   1140

tcggttcact gcaacctccg catccggggt tcaagccatt ctcctgcctc agcctcccaa   1200

gtagctggga ttacaggcat gtgtcaccat gcccggctaa ttttttttgt atttttagta   1260

gagacggggg tttcaccata ttggccagcc tggtctcgaa ctcctgacct tgtgatccac   1320

tcgcctcggc ctctcgaagt gctgagatta cacacgtgag caactgtgca aggcctggtg   1380

tttcttggta catgtaattc taccaaggtc ttcttaatat gttcttttaa atgattgaat   1440

tacatcttca gattattaaa gactaattct aatgtggacc ttagaataca gttttgagta   1500

gagttgatca aaatcaatta aaatagtctc ttttaaaagg aaagaaaaca tctttaaggg   1560

gaggaaccag agtgctgaag gaatggaagt ccatctgcgt gtgtgcaggg agactgggta   1620

ggaaagagga agcaaataga agagagaggt tgaaaaacaa aatgggttac ttgattggtg   1680

attaggtggt ggtagagaag caagtaaaaa ggctaaatgg aagggcaagt ttccatcatc   1740

tatagaaagc tatgtaagac aaggactccc ctttttttcc caaaggcatt gtaaaaagaa   1800

tgaagtctcc ttagaaaaaa aattatacct caatgtcccc aacaagattg cttaataaat   1860

tgtgtttcct ccaagctatt caattctttt aactgttgta gaagagaaaa tgttcacaat   1920

atatttagtt gtaaaccaag tgatcaaact acatattgta aagcccattt ttaaaataca   1980

ttgtatatac gtgtatgcac agtaaaaatg gaaactatat tgacct                  2026


<210>  4
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Cys Arg Lys Met Val Arg Phe Ser Tyr Ser Val Ile Trp Ile 
1               5                   10                  15      


Met Ala Ile Ser Lys Ala Phe Glu Leu Gly Leu Val Ala Gly Leu Gly 
            20                  25                  30          


His Gln Glu Phe Ala Arg Pro Ser Arg Gly Asp Leu Ala Phe Arg Asp 
        35                  40                  45              


Asp Ser Ile Trp Pro Gln Glu Glu Pro Ala Ile Arg Pro Arg Ser Ser 
    50                  55                  60                  


Gln Arg Val Leu Pro Met Gly Ile Gln His Ser Lys Glu Leu Asn Arg 
65                  70                  75                  80  


Thr Cys Cys Leu Asn Gly Gly Thr Cys Met Leu Glu Ser Phe Cys Ala 
                85                  90                  95      


Cys Pro Pro Ser Phe Tyr Gly Arg Asn Cys Glu His Asp Val Arg Lys 
            100                 105                 110         


Glu Asn Cys Gly Ser Val Pro His Asp Thr Trp Leu Pro Lys Lys Cys 
        115                 120                 125             


Ser Leu Cys Lys Cys Trp His Gly Gln Leu Arg Cys Phe Pro Gln Ala 
    130                 135                 140                 


Phe Leu Pro Gly Cys Asp Gly Leu Val Met Asp Glu His Leu Val Ala 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Leu Pro Pro Ser Ala Arg Thr Thr Thr Phe Met 
                165                 170                 175     


Leu Ala Gly Ile Cys Leu Ser Ile Gln Ser Tyr Tyr 
            180                 185             


<210>  5
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Cripto - Forward primer 1

<400>  5
gtacgcgatc ggtctttcc                                                  19


<210>  6
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Cripto - Forward primer 2

<400>  6
ggacttgcat cctggggtcc ttctgt                                          26


<210>  7
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Cripto - reverse primer

<400>  7
ccgtctgtga cgaccacttt t                                               21


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Alk4 forward primer

<400>  8
ggcccctgag gtacttgatg                                                 20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Alk4 - reverse primer

<400>  9
catcaagtac ctcaggggcc                                                 20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Glypican forward primer

<400>  10
ggggacctgt atacgcagaa                                                 20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Glypican reverse primer

<400>  11
caggtagtca tcaggcagca                                                 20


<210>  12
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Alk1 - forward primer

<400>  12
cttggggagc ttcagaaggg g                                               21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Alk1 - reverse primer

<400>  13
tgcctgttca gatgccttca g                                               21


<210>  14
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Alk5/TGFbRI - forward primer

<400>  14
atgggcaata gctggtttt                                                  19


<210>  15
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Alk5/TGFbRI - reverse primer

<400>  15
gccataaccg cactgtc                                                    17


<210>  16
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  TGFb - forward primer

<400>  16
ctcggggctg cggctactg                                                  19


<210>  17
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  TGFb - reverse primer

<400>  17
ggcgtatcag tgggggtca                                                  19


<210>  18
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  TFGbRII - forward primer

<400>  18
ggaagtctgc gtggccgtgt gg                                              22


<210>  19
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  TGFbRII - reverse primer

<400>  19
ctatggcaat ccccagcgga gg                                              22


