                         SEQUENCE LISTING

<110>  Oxford Genome Sciences
       Rohlff, Christian
 
<120>  PROTEIN

<130>  OGL-P121PCT

<160>  11    

<170>  PatentIn version 3.4

<210>  1
<211>  443
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(443)
<223>  Swisprot: Q8N2F4; Q9BY67; Ensembl: ENSG00000182985 IGSF4 (isoform
       1)

<400>  1

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Thr Thr Ala Thr 
                325                 330                 335     


Thr Glu Pro Ala Val His Gly Leu Thr Gln Leu Pro Asn Ser Ala Glu 
            340                 345                 350         


Glu Leu Asp Ser Glu Asp Leu Ser Asp Ser Arg Ala Gly Glu Glu Gly 
        355                 360                 365             


Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val 
    370                 375                 380                 


Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe 
385                 390                 395                 400 


Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp 
                405                 410                 415     


Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln 
            420                 425                 430         


Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
        435                 440             


<210>  2
<211>  442
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(442)
<223>  SwissProt: Q8N2F4; Q9BY67; Ensembl: ENSG00000182985 IGSF4 
       (isoform 2)

<400>  2

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Arg Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                325                 330                 335     


Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
            340                 345                 350         


Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser 
        355                 360                 365             


Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val 
    370                 375                 380                 


Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala 
385                 390                 395                 400 


Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp 
                405                 410                 415     


Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn 
            420                 425                 430         


Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
        435                 440         


<210>  3
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein: extracellular domain portion of IGSF4 fused 
       to a 6-His tag

<400>  3

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Thr Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val 
            20                  25                  30          


Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln 
        35                  40                  45              


Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro 
    50                  55                  60                  


Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe 
                85                  90                  95      


Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr 
            100                 105                 110         


Val Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Arg Asp Thr 
        115                 120                 125             


Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser 
    130                 135                 140                 


Lys Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys 
145                 150                 155                 160 


Gly Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser 
                165                 170                 175     


Gln Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro Val Ile 
            180                 185                 190         


Cys Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg 
        195                 200                 205             


Tyr Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr 
    210                 215                 220                 


Pro Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys 
225                 230                 235                 240 


Glu Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val Arg Val 
                245                 250                 255     


Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe 
            260                 265                 270         


Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala 
        275                 280                 285             


Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr 
    290                 295                 300                 


Asp Ser Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp Ala Ser 
305                 310                 315                 320 


His His His His His His 
                325     


<210>  4
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  4

Ala Gly Glu Glu Gly Ser Ile Arg 
1               5               


<210>  5
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  5

Cys Glu Ala Ser Asn Ile Val Gly Lys 
1               5                   


<210>  6
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  6

Asp Phe Arg Pro Leu Lys 
1               5       


<210>  7
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  7

Gly Thr Tyr Phe Thr His Glu Ala Lys 
1               5                   


<210>  8
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  8

Gln Thr Ile Tyr Phe Arg 
1               5       


<210>  9
<211>  13
<212>  PRT
<213>  Homo Sapiens

<400>  9

Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn Arg 
1               5                   10              


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  upstream primer for RT-PCR

<400>  10
ctctttgctg ctgcccatgt ttca                                            24


<210>  11
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  downstream primer for RT-PCR

<400>  11
aaacctttct ggacagcgta gggt                                            24


