                         SEQUENCE LISTING

<110>  BASF Aktiengesellschaft
 
<120>  Verfahren zur enzymatischen Reduktion von Alkinderivaten

<130>  M/47256

<160>  9     

<170>  PatentIn version 3.3

<210>  1
<211>  399
<212>  PRT
<213>  Saccharomyces carlsbergensis 

<400>  1

Ser Phe Val Lys Asp Phe Lys Pro Gln Ala Leu Gly Asp Thr Asn Leu 
1               5                   10                  15      


Phe Lys Pro Ile Lys Ile Gly Asn Asn Glu Leu Leu His Arg Ala Val 
            20                  25                  30          


Ile Pro Pro Leu Thr Arg Met Arg Ala Leu His Pro Gly Asn Ile Pro 
        35                  40                  45              


Asn Arg Asp Trp Ala Val Glu Tyr Tyr Thr Gln Arg Ala Gln Arg Pro 
    50                  55                  60                  


Gly Thr Met Ile Ile Thr Glu Gly Ala Phe Ile Ser Pro Gln Ala Gly 
65                  70                  75                  80  


Gly Tyr Asp Asn Ala Pro Gly Val Trp Ser Glu Glu Gln Met Val Glu 
                85                  90                  95      


Trp Thr Lys Ile Phe Asn Ala Ile His Glu Lys Lys Ser Phe Val Trp 
            100                 105                 110         


Val Gln Leu Trp Val Leu Gly Trp Ala Ala Phe Pro Asp Asn Leu Ala 
        115                 120                 125             


Arg Asp Gly Leu Arg Tyr Asp Ser Ala Ser Asp Asn Val Phe Met Asp 
    130                 135                 140                 


Ala Glu Gln Glu Ala Lys Ala Lys Lys Ala Asn Asn Pro Gln His Ser 
145                 150                 155                 160 


Leu Thr Lys Asp Glu Ile Lys Gln Tyr Ile Lys Glu Tyr Val Gln Ala 
                165                 170                 175     


Ala Lys Asn Ser Ile Ala Ala Gly Ala Asp Gly Val Glu Ile His Ser 
            180                 185                 190         


Ala Asn Gly Tyr Leu Leu Asn Gln Phe Leu Asp Pro His Ser Asn Thr 
        195                 200                 205             


Arg Thr Asp Glu Tyr Gly Gly Ser Ile Glu Asn Arg Ala Arg Phe Thr 
    210                 215                 220                 


Leu Glu Val Val Asp Ala Leu Val Glu Ala Ile Gly His Glu Lys Val 
225                 230                 235                 240 


Gly Leu Arg Leu Ser Pro Tyr Gly Val Phe Asn Ser Met Ser Gly Gly 
                245                 250                 255     


Ala Glu Thr Gly Ile Val Ala Gln Tyr Ala Tyr Val Ala Gly Glu Leu 
            260                 265                 270         


Glu Lys Arg Ala Lys Ala Gly Lys Arg Leu Ala Phe Val His Leu Val 
        275                 280                 285             


Glu Pro Arg Val Thr Asn Pro Phe Leu Thr Glu Gly Glu Gly Glu Tyr 
    290                 295                 300                 


Glu Gly Gly Ser Asn Asp Phe Val Tyr Ser Ile Trp Lys Gly Pro Val 
305                 310                 315                 320 


Ile Arg Ala Gly Asn Phe Ala Leu His Pro Glu Val Val Arg Glu Glu 
                325                 330                 335     


Val Lys Asp Lys Arg Thr Leu Ile Gly Tyr Gly Arg Phe Phe Ile Ser 
            340                 345                 350         


Asn Pro Asp Leu Val Asp Arg Leu Glu Lys Gly Leu Pro Leu Asn Lys 
        355                 360                 365             


Tyr Asp Arg Asp Thr Phe Tyr Gln Met Ser Ala His Gly Tyr Ile Asp 
    370                 375                 380                 


Tyr Pro Thr Tyr Glu Glu Ala Leu Lys Leu Gly Trp Asp Lys Lys 
385                 390                 395                 


<210>  2
<211>  399
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Pro Phe Val Lys Asp Phe Lys Pro Gln Ala Leu Gly Asp Thr Asn Leu 
1               5                   10                  15      


Phe Lys Pro Ile Lys Ile Gly Asn Asn Glu Leu Leu His Arg Ala Val 
            20                  25                  30          


Ile Pro Pro Leu Thr Arg Met Arg Ala Gln His Pro Gly Asn Ile Pro 
        35                  40                  45              


Asn Arg Asp Trp Ala Val Glu Tyr Tyr Ala Gln Arg Ala Gln Arg Pro 
    50                  55                  60                  


Gly Thr Leu Ile Ile Thr Glu Gly Thr Phe Pro Ser Pro Gln Ser Gly 
65                  70                  75                  80  


Gly Tyr Asp Asn Ala Pro Gly Ile Trp Ser Glu Glu Gln Ile Lys Glu 
                85                  90                  95      


Trp Thr Lys Ile Phe Lys Ala Ile His Glu Asn Lys Ser Phe Ala Trp 
            100                 105                 110         


Val Gln Leu Trp Val Leu Gly Trp Ala Ala Phe Pro Asp Thr Leu Ala 
        115                 120                 125             


Arg Asp Gly Leu Arg Tyr Asp Ser Ala Ser Asp Asn Val Tyr Met Asn 
    130                 135                 140                 


Ala Glu Gln Glu Glu Lys Ala Lys Lys Ala Asn Asn Pro Gln His Ser 
145                 150                 155                 160 


Ile Thr Lys Asp Glu Ile Lys Gln Tyr Val Lys Glu Tyr Val Gln Ala 
                165                 170                 175     


Ala Lys Asn Ser Ile Ala Ala Gly Ala Asp Gly Val Glu Ile His Ser 
            180                 185                 190         


Ala Asn Gly Tyr Leu Leu Asn Gln Phe Leu Asp Pro His Ser Asn Asn 
        195                 200                 205             


Arg Thr Asp Glu Tyr Gly Gly Ser Ile Glu Asn Arg Ala Arg Phe Thr 
    210                 215                 220                 


Leu Glu Val Val Asp Ala Val Val Asp Ala Ile Gly Pro Glu Lys Val 
225                 230                 235                 240 


Gly Leu Arg Leu Ser Pro Tyr Gly Val Phe Asn Ser Met Ser Gly Gly 
                245                 250                 255     


Ala Glu Thr Gly Ile Val Ala Gln Tyr Ala Tyr Val Leu Gly Glu Leu 
            260                 265                 270         


Glu Arg Arg Ala Lys Ala Gly Lys Arg Leu Ala Phe Val His Leu Val 
        275                 280                 285             


Glu Pro Arg Val Thr Asn Pro Phe Leu Thr Glu Gly Glu Gly Glu Tyr 
    290                 295                 300                 


Asn Gly Gly Ser Asn Lys Phe Ala Tyr Ser Ile Trp Lys Gly Pro Ile 
305                 310                 315                 320 


Ile Arg Ala Gly Asn Phe Ala Leu His Pro Glu Val Val Arg Glu Glu 
                325                 330                 335     


Val Lys Asp Pro Arg Thr Leu Ile Gly Tyr Gly Arg Phe Phe Ile Ser 
            340                 345                 350         


Asn Pro Asp Leu Val Asp Arg Leu Glu Lys Gly Leu Pro Leu Asn Lys 
        355                 360                 365             


Tyr Asp Arg Asp Thr Phe Tyr Lys Met Ser Ala Glu Gly Tyr Ile Asp 
    370                 375                 380                 


Tyr Pro Thr Tyr Glu Glu Ala Leu Lys Leu Gly Trp Asp Lys Asn 
385                 390                 395                 


<210>  3
<211>  399
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Pro Phe Val Lys Gly Phe Glu Pro Ile Ser Leu Arg Asp Thr Asn Leu 
1               5                   10                  15      


Phe Glu Pro Ile Lys Ile Gly Asn Thr Gln Leu Ala His Arg Ala Val 
            20                  25                  30          


Met Pro Pro Leu Thr Arg Met Arg Ala Thr His Pro Gly Asn Ile Pro 
        35                  40                  45              


Asn Lys Glu Trp Ala Ala Val Tyr Tyr Gly Gln Arg Ala Gln Arg Pro 
    50                  55                  60                  


Gly Thr Met Ile Ile Thr Glu Gly Thr Phe Ile Ser Pro Gln Ala Gly 
65                  70                  75                  80  


Gly Tyr Asp Asn Ala Pro Gly Ile Trp Ser Asp Glu Gln Val Ala Glu 
                85                  90                  95      


Trp Lys Asn Ile Phe Leu Ala Ile His Asp Cys Gln Ser Phe Ala Trp 
            100                 105                 110         


Val Gln Leu Trp Ser Leu Gly Trp Ala Ser Phe Pro Asp Val Leu Ala 
        115                 120                 125             


Arg Asp Gly Leu Arg Tyr Asp Cys Ala Ser Asp Arg Val Tyr Met Asn 
    130                 135                 140                 


Ala Thr Leu Gln Glu Lys Ala Lys Asp Ala Asn Asn Leu Glu His Ser 
145                 150                 155                 160 


Leu Thr Lys Asp Asp Ile Lys Gln Tyr Ile Lys Asp Tyr Ile His Ala 
                165                 170                 175     


Ala Lys Asn Ser Ile Ala Ala Gly Ala Asp Gly Val Glu Ile His Ser 
            180                 185                 190         


Ala Asn Gly Tyr Leu Leu Asn Gln Phe Leu Asp Pro His Ser Asn Lys 
        195                 200                 205             


Arg Thr Asp Glu Tyr Gly Gly Thr Ile Glu Asn Arg Ala Arg Phe Thr 
    210                 215                 220                 


Leu Glu Val Val Asp Ala Leu Ile Glu Thr Ile Gly Pro Glu Arg Val 
225                 230                 235                 240 


Gly Leu Arg Leu Ser Pro Tyr Gly Thr Phe Asn Ser Met Ser Gly Gly 
                245                 250                 255     


Ala Glu Pro Gly Ile Ile Ala Gln Tyr Ser Tyr Val Leu Gly Glu Leu 
            260                 265                 270         


Glu Lys Arg Ala Lys Ala Gly Lys Arg Leu Ala Phe Val His Leu Val 
        275                 280                 285             


Glu Pro Arg Val Thr Asp Pro Ser Leu Val Glu Gly Glu Gly Glu Tyr 
    290                 295                 300                 


Ser Glu Gly Thr Asn Asp Phe Ala Tyr Ser Ile Trp Lys Gly Pro Ile 
305                 310                 315                 320 


Ile Arg Ala Gly Asn Tyr Ala Leu His Pro Glu Val Val Arg Glu Gln 
                325                 330                 335     


Val Lys Asp Pro Arg Thr Leu Ile Gly Tyr Gly Arg Phe Phe Ile Ser 
            340                 345                 350         


Asn Pro Asp Leu Val Tyr Arg Leu Glu Glu Gly Leu Pro Leu Asn Lys 
        355                 360                 365             


Tyr Asp Arg Ser Thr Phe Tyr Thr Met Ser Ala Glu Gly Tyr Thr Asp 
    370                 375                 380                 


Tyr Pro Thr Tyr Glu Glu Ala Val Asp Leu Gly Trp Asn Lys Asn 
385                 390                 395                 


<210>  4
<211>  5490
<212>  DNA
<213>  Artificial

<220>
<223>  Plamid encoding OYE1


<220>
<221>  CDS
<222>  (4)..(1203)

<400>  4
cat atg agc ttt gtg aaa gat ttt aaa ccg cag gcg ctg ggc gat acc       48
    Met Ser Phe Val Lys Asp Phe Lys Pro Gln Ala Leu Gly Asp Thr         
    1               5                   10                  15          

aac ctg ttt aaa ccg att aaa att ggc aac aac gaa ctg ctg cat cgc       96
Asn Leu Phe Lys Pro Ile Lys Ile Gly Asn Asn Glu Leu Leu His Arg         
                20                  25                  30              

gcg gtg att ccg ccg ctg acc cgc atg cgc gcg ctg cat ccg ggc aac      144
Ala Val Ile Pro Pro Leu Thr Arg Met Arg Ala Leu His Pro Gly Asn         
            35                  40                  45                  

att ccg aac cgc gat tgg gcg gtg gaa tat tat acc cag cgc gcg cag      192
Ile Pro Asn Arg Asp Trp Ala Val Glu Tyr Tyr Thr Gln Arg Ala Gln         
        50                  55                  60                      

cgc ccg ggc acc atg att att acc gaa ggc gcg ttt att agc ccg cag      240
Arg Pro Gly Thr Met Ile Ile Thr Glu Gly Ala Phe Ile Ser Pro Gln         
    65                  70                  75                          

gcg ggc ggc tat gat aac gcg ccg ggc gtg tgg agc gaa gaa cag atg      288
Ala Gly Gly Tyr Asp Asn Ala Pro Gly Val Trp Ser Glu Glu Gln Met         
80                  85                  90                  95          

gtg gaa tgg acc aaa att ttt aac gcg att cat gaa aaa aaa agc ttt      336
Val Glu Trp Thr Lys Ile Phe Asn Ala Ile His Glu Lys Lys Ser Phe         
                100                 105                 110             

gtg tgg gtg cag ctg tgg gtg ctg ggc tgg gcg gcg ttt ccg gat aac      384
Val Trp Val Gln Leu Trp Val Leu Gly Trp Ala Ala Phe Pro Asp Asn         
            115                 120                 125                 

ctg gcg cgc gat ggc ctg cgc tat gat agc gcg agc gat aac gtg ttt      432
Leu Ala Arg Asp Gly Leu Arg Tyr Asp Ser Ala Ser Asp Asn Val Phe         
        130                 135                 140                     

atg gat gcg gaa cag gaa gcg aaa gcg aaa aaa gcg aac aac ccg cag      480
Met Asp Ala Glu Gln Glu Ala Lys Ala Lys Lys Ala Asn Asn Pro Gln         
    145                 150                 155                         

cat agc ctg acc aaa gat gaa att aaa cag tat att aaa gaa tat gtg      528
His Ser Leu Thr Lys Asp Glu Ile Lys Gln Tyr Ile Lys Glu Tyr Val         
160                 165                 170                 175         

cag gcg gcg aaa aac agc att gcg gcg ggc gcg gat ggc gtg gaa att      576
Gln Ala Ala Lys Asn Ser Ile Ala Ala Gly Ala Asp Gly Val Glu Ile         
                180                 185                 190             

cat agc gcg aac ggc tat ctg ctg aac cag ttt ctg gat ccg cat agc      624
His Ser Ala Asn Gly Tyr Leu Leu Asn Gln Phe Leu Asp Pro His Ser         
            195                 200                 205                 

aac acc cgc acc gat gaa tat ggc ggc agc att gaa aac cgc gcg cgc      672
Asn Thr Arg Thr Asp Glu Tyr Gly Gly Ser Ile Glu Asn Arg Ala Arg         
        210                 215                 220                     

ttt acc ctg gaa gtg gtg gat gcg ctg gtg gaa gcg att ggc cat gaa      720
Phe Thr Leu Glu Val Val Asp Ala Leu Val Glu Ala Ile Gly His Glu         
    225                 230                 235                         

aaa gtg ggc ctg cgc ctg agc ccg tat ggc gtg ttt aac agc atg agc      768
Lys Val Gly Leu Arg Leu Ser Pro Tyr Gly Val Phe Asn Ser Met Ser         
240                 245                 250                 255         

ggc ggc gcg gaa acc ggc att gtg gcg cag tat gcg tat gtg gcg ggc      816
Gly Gly Ala Glu Thr Gly Ile Val Ala Gln Tyr Ala Tyr Val Ala Gly         
                260                 265                 270             

gaa ctg gaa aaa cgc gcg aaa gcg ggc aaa cgc ctg gcg ttt gtg cat      864
Glu Leu Glu Lys Arg Ala Lys Ala Gly Lys Arg Leu Ala Phe Val His         
            275                 280                 285                 

ctg gtg gaa ccg cgc gtg acc aac ccg ttt ctg acc gaa ggc gaa ggc      912
Leu Val Glu Pro Arg Val Thr Asn Pro Phe Leu Thr Glu Gly Glu Gly         
        290                 295                 300                     

gaa tat gaa ggc ggc agc aac gat ttt gtg tat agc att tgg aaa ggc      960
Glu Tyr Glu Gly Gly Ser Asn Asp Phe Val Tyr Ser Ile Trp Lys Gly         
    305                 310                 315                         

ccg gtg att cgc gcg ggc aac ttt gcg ctg cat ccg gaa gtg gtg cgc     1008
Pro Val Ile Arg Ala Gly Asn Phe Ala Leu His Pro Glu Val Val Arg         
320                 325                 330                 335         

gaa gaa gtg aaa gat aaa cgc acc ctg att ggc tat ggc cgc ttt ttt     1056
Glu Glu Val Lys Asp Lys Arg Thr Leu Ile Gly Tyr Gly Arg Phe Phe         
                340                 345                 350             

att agc aac ccg gat ctg gtg gat cgc ctg gaa aaa ggc ctg ccg ctg     1104
Ile Ser Asn Pro Asp Leu Val Asp Arg Leu Glu Lys Gly Leu Pro Leu         
            355                 360                 365                 

aac aaa tat gat cgc gat acc ttt tat cag atg agc gcg cat ggc tat     1152
Asn Lys Tyr Asp Arg Asp Thr Phe Tyr Gln Met Ser Ala His Gly Tyr         
        370                 375                 380                     

att gat tat ccg acc tat gaa gaa gcg ctg aaa ctg ggc tgg gat aaa     1200
Ile Asp Tyr Pro Thr Tyr Glu Glu Ala Leu Lys Leu Gly Trp Asp Lys         
    385                 390                 395                         

aaa tgacttaact gcagccaagc ttggctgttt tggcggatga gagaagattt          1253
Lys                                                                     
400                                                                     

tcagcctgat acagattaaa tcagaacgca gaagcggtct gataaaacag aatttgcctg   1313

gcggcagtag cgcggtggtc ccacctgacc ccatgccgaa ctcagaagtg aaacgccgta   1373

gcgccgatgg tagtgtgggg tctccccatg cgagagtagg gaactgccag gcatcaaata   1433

aaacgaaagg ctcagtcgaa agactgggcc tttcgtttta tctgttgttt gtcggtgaac   1493

gctctcctga gtaggacaaa tccgccggga gcggatttga acgttgcgaa gcaacggccc   1553

ggagggtggc gggcaggacg cccgccataa actgccaggc atcaaattaa gcagaaggcc   1613

atcctgacgg atggcctttt tgcgtttcta caaactcttt tgtttatttt tctaaataca   1673

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa   1733

aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt   1793

tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag   1853

ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt   1913

tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg   1973

gtattatccc gtgttgacgc cgggcaagag caactcggtc gccgcataca ctattctcag   2033

aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta   2093

agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg   2153

acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta   2213

actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac   2273

accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt   2333

actctagctt cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca   2393

cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag   2453

cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta   2513

gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag   2573

ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt   2633

tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat   2693

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta   2753

gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa   2813

acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt   2873

tttccgaagg taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag   2933

ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta   2993

atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca   3053

agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag   3113

cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa   3173

agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga   3233

acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc   3293

gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc   3353

ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt   3413

gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt   3473

gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag   3533

gaagcggaag agcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac   3593

cgcatatatg gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagtata   3653

cactccgcta tcgctacgtg actgggtcat ggctgcgccc cgacacccgc caacacccgc   3713

tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt   3773

ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgaggcagct   3833

gcggtaaagc tcatcagcgt ggtcgtgaag cgattcacag atgtctgcct gttcatccgc   3893

gtccagctcg ttgagtttct ccagaagcgt taatgtctgg cttctgataa agcgggccat   3953

gttaagggcg gttttttcct gtttggtcac ttgatgcctc cgtgtaaggg ggaatttctg   4013

ttcatggggg taatgatacc gatgaaacga gagaggatgc tcacgatacg ggttactgat   4073

gatgaacatg cccggttact ggaacgttgt gagggtaaac aactggcggt atggatgcgg   4133

cgggaccaga gaaaaatcac tcagggtcaa tgccagcgct tcgttaatac agatgtaggt   4193

gttccacagg gtagccagca gcatcctgcg atgcagatcc ggaacataat ggtgcagggc   4253

gctgacttcc gcgtttccag actttacgaa acacggaaac cgaagaccat tcatgttgtt   4313

gctcaggtcg cagacgtttt gcagcagcag tcgcttcacg ttcgctcgcg tatcggtgat   4373

tcattctgct aaccagtaag gcaaccccgc cagcctagcc gggtcctcaa cgacaggagc   4433

acgatcatgc gcacccgtgg ccaggaccca acgctgcccg agatgcgccg cgtgcggctg   4493

ctggagatgg cggacgcgat ggatatgttc tgccaagggt tggtttgcgc attcacagtt   4553

ctccgcaaga attgattggc tccaattctt ggagtggtga atccgttagc gaggtgccgc   4613

cggcttccat tcaggtcgag gtggcccggc tccatgcacc gcgacgcaac gcggggaggc   4673

agacaaggta tagggcggcg cctacaatcc atgccaaccc gttccatgtg ctcgccgagg   4733

cggcataaat cgccgtgacg atcagcggtc cagtgatcga agttaggctg gtaagagccg   4793

cgagcgatcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac agcatggcct   4853

gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg aaggccatcc   4913

agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccgcc atgccggcga   4973

taatggcctg cttctcgccg aaacgtttgg tggcgggacc agtgacgaag gcttgagcga   5033

gggcgtgcaa gattccgaat accgcaagcg acaggccgat catcgtcgcg ctccagcgaa   5093

agcggtcctc gccgaaaatg acccagagcg ctgccggcac ctgtcctacg agttgcatga   5153

taaagaagac agtcataagt gcggcgacga tagtcatgcc ccgcgcccac cggaaggagc   5213

tgactgggtt gaaggctctc aagggcatcg gtcgacgctc tcccttatgc gactcctgca   5273

ttaggaagca gcccagtagt aggttgaggc cgttgagcac cgccgccgca aggaatggtg   5333

catgcatcga tcaccacaat tcagcaaatt gtgaacatca tcacgttcat ctttccctgg   5393

ttgccaatgg cccattttcc tgtcagtaac gagaaggtcg cgaattcagg cgctttttag   5453

actggtcgta atgaacaatt cttaagaagg agatata                            5490


<210>  5
<211>  400
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  5

Met Ser Phe Val Lys Asp Phe Lys Pro Gln Ala Leu Gly Asp Thr Asn 
1               5                   10                  15      


Leu Phe Lys Pro Ile Lys Ile Gly Asn Asn Glu Leu Leu His Arg Ala 
            20                  25                  30          


Val Ile Pro Pro Leu Thr Arg Met Arg Ala Leu His Pro Gly Asn Ile 
        35                  40                  45              


Pro Asn Arg Asp Trp Ala Val Glu Tyr Tyr Thr Gln Arg Ala Gln Arg 
    50                  55                  60                  


Pro Gly Thr Met Ile Ile Thr Glu Gly Ala Phe Ile Ser Pro Gln Ala 
65                  70                  75                  80  


Gly Gly Tyr Asp Asn Ala Pro Gly Val Trp Ser Glu Glu Gln Met Val 
                85                  90                  95      


Glu Trp Thr Lys Ile Phe Asn Ala Ile His Glu Lys Lys Ser Phe Val 
            100                 105                 110         


Trp Val Gln Leu Trp Val Leu Gly Trp Ala Ala Phe Pro Asp Asn Leu 
        115                 120                 125             


Ala Arg Asp Gly Leu Arg Tyr Asp Ser Ala Ser Asp Asn Val Phe Met 
    130                 135                 140                 


Asp Ala Glu Gln Glu Ala Lys Ala Lys Lys Ala Asn Asn Pro Gln His 
145                 150                 155                 160 


Ser Leu Thr Lys Asp Glu Ile Lys Gln Tyr Ile Lys Glu Tyr Val Gln 
                165                 170                 175     


Ala Ala Lys Asn Ser Ile Ala Ala Gly Ala Asp Gly Val Glu Ile His 
            180                 185                 190         


Ser Ala Asn Gly Tyr Leu Leu Asn Gln Phe Leu Asp Pro His Ser Asn 
        195                 200                 205             


Thr Arg Thr Asp Glu Tyr Gly Gly Ser Ile Glu Asn Arg Ala Arg Phe 
    210                 215                 220                 


Thr Leu Glu Val Val Asp Ala Leu Val Glu Ala Ile Gly His Glu Lys 
225                 230                 235                 240 


Val Gly Leu Arg Leu Ser Pro Tyr Gly Val Phe Asn Ser Met Ser Gly 
                245                 250                 255     


Gly Ala Glu Thr Gly Ile Val Ala Gln Tyr Ala Tyr Val Ala Gly Glu 
            260                 265                 270         


Leu Glu Lys Arg Ala Lys Ala Gly Lys Arg Leu Ala Phe Val His Leu 
        275                 280                 285             


Val Glu Pro Arg Val Thr Asn Pro Phe Leu Thr Glu Gly Glu Gly Glu 
    290                 295                 300                 


Tyr Glu Gly Gly Ser Asn Asp Phe Val Tyr Ser Ile Trp Lys Gly Pro 
305                 310                 315                 320 


Val Ile Arg Ala Gly Asn Phe Ala Leu His Pro Glu Val Val Arg Glu 
                325                 330                 335     


Glu Val Lys Asp Lys Arg Thr Leu Ile Gly Tyr Gly Arg Phe Phe Ile 
            340                 345                 350         


Ser Asn Pro Asp Leu Val Asp Arg Leu Glu Lys Gly Leu Pro Leu Asn 
        355                 360                 365             


Lys Tyr Asp Arg Asp Thr Phe Tyr Gln Met Ser Ala His Gly Tyr Ile 
    370                 375                 380                 


Asp Tyr Pro Thr Tyr Glu Glu Ala Leu Lys Leu Gly Trp Asp Lys Lys 
385                 390                 395                 400 


<210>  6
<211>  5491
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid encoding OYE2


<220>
<221>  CDS
<222>  (4)..(1203)

<400>  6
cat atg ccg ttt gtg aaa gat ttt aaa ccg cag gcg ctg ggc gat acc       48
    Met Pro Phe Val Lys Asp Phe Lys Pro Gln Ala Leu Gly Asp Thr         
    1               5                   10                  15          

aac ctg ttt aaa ccg att aaa att ggc aac aac gaa ctg ctg cat cgc       96
Asn Leu Phe Lys Pro Ile Lys Ile Gly Asn Asn Glu Leu Leu His Arg         
                20                  25                  30              

gcg gtg att ccg ccg ctg acc cgc atg cgc gcg cag cat ccg ggc aac      144
Ala Val Ile Pro Pro Leu Thr Arg Met Arg Ala Gln His Pro Gly Asn         
            35                  40                  45                  

att ccg aac cgc gat tgg gcg gtg gaa tat tat gcg cag cgc gcg cag      192
Ile Pro Asn Arg Asp Trp Ala Val Glu Tyr Tyr Ala Gln Arg Ala Gln         
        50                  55                  60                      

cgc ccg ggc acc ctg att att acc gaa ggc acc ttt ccg agc ccg cag      240
Arg Pro Gly Thr Leu Ile Ile Thr Glu Gly Thr Phe Pro Ser Pro Gln         
    65                  70                  75                          

agc ggc ggc tat gat aac gcg ccg ggc att tgg agc gaa gaa cag att      288
Ser Gly Gly Tyr Asp Asn Ala Pro Gly Ile Trp Ser Glu Glu Gln Ile         
80                  85                  90                  95          

aaa gaa tgg acc aaa att ttt aaa gcg att cat gaa aac aaa agc ttt      336
Lys Glu Trp Thr Lys Ile Phe Lys Ala Ile His Glu Asn Lys Ser Phe         
                100                 105                 110             

gcg tgg gtg cag ctg tgg gtg ctg ggc tgg gcg gcg ttt ccg gat acc      384
Ala Trp Val Gln Leu Trp Val Leu Gly Trp Ala Ala Phe Pro Asp Thr         
            115                 120                 125                 

ctg gcg cgc gat ggc ctg cgc tat gat agc gcg agc gat aac gtg tat      432
Leu Ala Arg Asp Gly Leu Arg Tyr Asp Ser Ala Ser Asp Asn Val Tyr         
        130                 135                 140                     

atg aac gcg gaa cag gaa gaa aaa gcg aaa aaa gcg aac aac ccg cag      480
Met Asn Ala Glu Gln Glu Glu Lys Ala Lys Lys Ala Asn Asn Pro Gln         
    145                 150                 155                         

cat agc att acc aaa gat gaa att aaa cag tat gtg aaa gaa tat gtg      528
His Ser Ile Thr Lys Asp Glu Ile Lys Gln Tyr Val Lys Glu Tyr Val         
160                 165                 170                 175         

cag gcg gcg aaa aac agc att gcg gcg ggc gcg gat ggc gtg gaa att      576
Gln Ala Ala Lys Asn Ser Ile Ala Ala Gly Ala Asp Gly Val Glu Ile         
                180                 185                 190             

cat agc gcg aac ggc tat ctg ctg aac cag ttt ctg gat ccg cat agc      624
His Ser Ala Asn Gly Tyr Leu Leu Asn Gln Phe Leu Asp Pro His Ser         
            195                 200                 205                 

aac aac cgc acc gat gaa tat ggc ggc agc att gaa aac cgc gcg cgc      672
Asn Asn Arg Thr Asp Glu Tyr Gly Gly Ser Ile Glu Asn Arg Ala Arg         
        210                 215                 220                     

ttt acc ctg gaa gtg gtg gat gcg gtg gtg gat gcg att ggc ccg gaa      720
Phe Thr Leu Glu Val Val Asp Ala Val Val Asp Ala Ile Gly Pro Glu         
    225                 230                 235                         

aaa gtg ggc ctg cgc ctg agc ccg tat ggc gtg ttt aac agc atg agc      768
Lys Val Gly Leu Arg Leu Ser Pro Tyr Gly Val Phe Asn Ser Met Ser         
240                 245                 250                 255         

ggc ggc gcg gaa acc ggc att gtg gcg cag tat gcg tat gtg ctg ggc      816
Gly Gly Ala Glu Thr Gly Ile Val Ala Gln Tyr Ala Tyr Val Leu Gly         
                260                 265                 270             

gaa ctg gaa cgc cgc gcg aaa gcg ggc aaa cgc ctg gcg ttt gtg cat      864
Glu Leu Glu Arg Arg Ala Lys Ala Gly Lys Arg Leu Ala Phe Val His         
            275                 280                 285                 

ctg gtg gaa ccg cgc gtg acc aac ccg ttt ctg acc gaa ggc gaa ggc      912
Leu Val Glu Pro Arg Val Thr Asn Pro Phe Leu Thr Glu Gly Glu Gly         
        290                 295                 300                     

gaa tat aac ggc ggc agc aac aaa ttt gcg tat agc att tgg aaa ggc      960
Glu Tyr Asn Gly Gly Ser Asn Lys Phe Ala Tyr Ser Ile Trp Lys Gly         
    305                 310                 315                         

ccg att att cgc gcg ggc aac ttt gcg ctg cat ccg gaa gtg gtg cgc     1008
Pro Ile Ile Arg Ala Gly Asn Phe Ala Leu His Pro Glu Val Val Arg         
320                 325                 330                 335         

gaa gaa gtg aaa gat ccg cgc acc ctg att ggc tat ggc cgc ttt ttt     1056
Glu Glu Val Lys Asp Pro Arg Thr Leu Ile Gly Tyr Gly Arg Phe Phe         
                340                 345                 350             

att agc aac ccg gat ctg gtg gat cgc ctg gaa aaa ggc ctg ccg ctg     1104
Ile Ser Asn Pro Asp Leu Val Asp Arg Leu Glu Lys Gly Leu Pro Leu         
            355                 360                 365                 

aac aaa tat gat cgc gat acc ttt tat aaa atg agc gcg gaa ggc tat     1152
Asn Lys Tyr Asp Arg Asp Thr Phe Tyr Lys Met Ser Ala Glu Gly Tyr         
        370                 375                 380                     

att gat tat ccg acc tat gaa gaa gcg ctg aaa ctg ggc tgg gat aaa     1200
Ile Asp Tyr Pro Thr Tyr Glu Glu Ala Leu Lys Leu Gly Trp Asp Lys         
    385                 390                 395                         

aac atgacttaac tgcagccaag cttggctgtt ttggcggatg agagaagatt          1253
Asn                                                                     
400                                                                     

ttcagcctga tacagattaa atcagaacgc agaagcggtc tgataaaaca gaatttgcct   1313

ggcggcagta gcgcggtggt cccacctgac cccatgccga actcagaagt gaaacgccgt   1373

agcgccgatg gtagtgtggg gtctccccat gcgagagtag ggaactgcca ggcatcaaat   1433

aaaacgaaag gctcagtcga aagactgggc ctttcgtttt atctgttgtt tgtcggtgaa   1493

cgctctcctg agtaggacaa atccgccggg agcggatttg aacgttgcga agcaacggcc   1553

cggagggtgg cgggcaggac gcccgccata aactgccagg catcaaatta agcagaaggc   1613

catcctgacg gatggccttt ttgcgtttct acaaactctt ttgtttattt ttctaaatac   1673

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa   1733

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt   1793

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca   1853

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag   1913

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc   1973

ggtattatcc cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca   2033

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt   2093

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct   2153

gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt   2213

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga   2273

caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact   2333

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc   2393

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga   2453

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt   2513

agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga   2573

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact   2633

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga   2693

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt   2753

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca   2813

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct   2873

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta   2933

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct   2993

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc   3053

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca   3113

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga   3173

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg   3233

aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt   3293

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag   3353

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt   3413

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt   3473

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga   3533

ggaagcggaa gagcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca   3593

ccgcatatat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagtat   3653

acactccgct atcgctacgt gactgggtca tggctgcgcc ccgacacccg ccaacacccg   3713

ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg   3773

tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgaggcagc   3833

tgcggtaaag ctcatcagcg tggtcgtgaa gcgattcaca gatgtctgcc tgttcatccg   3893

cgtccagctc gttgagtttc tccagaagcg ttaatgtctg gcttctgata aagcgggcca   3953

tgttaagggc ggttttttcc tgtttggtca cttgatgcct ccgtgtaagg gggaatttct   4013

gttcatgggg gtaatgatac cgatgaaacg agagaggatg ctcacgatac gggttactga   4073

tgatgaacat gcccggttac tggaacgttg tgagggtaaa caactggcgg tatggatgcg   4133

gcgggaccag agaaaaatca ctcagggtca atgccagcgc ttcgttaata cagatgtagg   4193

tgttccacag ggtagccagc agcatcctgc gatgcagatc cggaacataa tggtgcaggg   4253

cgctgacttc cgcgtttcca gactttacga aacacggaaa ccgaagacca ttcatgttgt   4313

tgctcaggtc gcagacgttt tgcagcagca gtcgcttcac gttcgctcgc gtatcggtga   4373

ttcattctgc taaccagtaa ggcaaccccg ccagcctagc cgggtcctca acgacaggag   4433

cacgatcatg cgcacccgtg gccaggaccc aacgctgccc gagatgcgcc gcgtgcggct   4493

gctggagatg gcggacgcga tggatatgtt ctgccaaggg ttggtttgcg cattcacagt   4553

tctccgcaag aattgattgg ctccaattct tggagtggtg aatccgttag cgaggtgccg   4613

ccggcttcca ttcaggtcga ggtggcccgg ctccatgcac cgcgacgcaa cgcggggagg   4673

cagacaaggt atagggcggc gcctacaatc catgccaacc cgttccatgt gctcgccgag   4733

gcggcataaa tcgccgtgac gatcagcggt ccagtgatcg aagttaggct ggtaagagcc   4793

gcgagcgatc cttgaagctg tccctgatgg tcgtcatcta cctgcctgga cagcatggcc   4853

tgcaacgcgg gcatcccgat gccgccggaa gcgagaagaa tcataatggg gaaggccatc   4913

cagcctcgcg tcgcgaacgc cagcaagacg tagcccagcg cgtcggccgc catgccggcg   4973

ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa ggcttgagcg   5033

agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc gctccagcga   5093

aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac gagttgcatg   5153

ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca ccggaaggag   5213

ctgactgggt tgaaggctct caagggcatc ggtcgacgct ctcccttatg cgactcctgc   5273

attaggaagc agcccagtag taggttgagg ccgttgagca ccgccgccgc aaggaatggt   5333

gcatgcatcg atcaccacaa ttcagcaaat tgtgaacatc atcacgttca tctttccctg   5393

gttgccaatg gcccattttc ctgtcagtaa cgagaaggtc gcgaattcag gcgcttttta   5453

gactggtcgt aatgaacaat tcttaagaag gagatata                           5491


<210>  7
<211>  400
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  7

Met Pro Phe Val Lys Asp Phe Lys Pro Gln Ala Leu Gly Asp Thr Asn 
1               5                   10                  15      


Leu Phe Lys Pro Ile Lys Ile Gly Asn Asn Glu Leu Leu His Arg Ala 
            20                  25                  30          


Val Ile Pro Pro Leu Thr Arg Met Arg Ala Gln His Pro Gly Asn Ile 
        35                  40                  45              


Pro Asn Arg Asp Trp Ala Val Glu Tyr Tyr Ala Gln Arg Ala Gln Arg 
    50                  55                  60                  


Pro Gly Thr Leu Ile Ile Thr Glu Gly Thr Phe Pro Ser Pro Gln Ser 
65                  70                  75                  80  


Gly Gly Tyr Asp Asn Ala Pro Gly Ile Trp Ser Glu Glu Gln Ile Lys 
                85                  90                  95      


Glu Trp Thr Lys Ile Phe Lys Ala Ile His Glu Asn Lys Ser Phe Ala 
            100                 105                 110         


Trp Val Gln Leu Trp Val Leu Gly Trp Ala Ala Phe Pro Asp Thr Leu 
        115                 120                 125             


Ala Arg Asp Gly Leu Arg Tyr Asp Ser Ala Ser Asp Asn Val Tyr Met 
    130                 135                 140                 


Asn Ala Glu Gln Glu Glu Lys Ala Lys Lys Ala Asn Asn Pro Gln His 
145                 150                 155                 160 


Ser Ile Thr Lys Asp Glu Ile Lys Gln Tyr Val Lys Glu Tyr Val Gln 
                165                 170                 175     


Ala Ala Lys Asn Ser Ile Ala Ala Gly Ala Asp Gly Val Glu Ile His 
            180                 185                 190         


Ser Ala Asn Gly Tyr Leu Leu Asn Gln Phe Leu Asp Pro His Ser Asn 
        195                 200                 205             


Asn Arg Thr Asp Glu Tyr Gly Gly Ser Ile Glu Asn Arg Ala Arg Phe 
    210                 215                 220                 


Thr Leu Glu Val Val Asp Ala Val Val Asp Ala Ile Gly Pro Glu Lys 
225                 230                 235                 240 


Val Gly Leu Arg Leu Ser Pro Tyr Gly Val Phe Asn Ser Met Ser Gly 
                245                 250                 255     


Gly Ala Glu Thr Gly Ile Val Ala Gln Tyr Ala Tyr Val Leu Gly Glu 
            260                 265                 270         


Leu Glu Arg Arg Ala Lys Ala Gly Lys Arg Leu Ala Phe Val His Leu 
        275                 280                 285             


Val Glu Pro Arg Val Thr Asn Pro Phe Leu Thr Glu Gly Glu Gly Glu 
    290                 295                 300                 


Tyr Asn Gly Gly Ser Asn Lys Phe Ala Tyr Ser Ile Trp Lys Gly Pro 
305                 310                 315                 320 


Ile Ile Arg Ala Gly Asn Phe Ala Leu His Pro Glu Val Val Arg Glu 
                325                 330                 335     


Glu Val Lys Asp Pro Arg Thr Leu Ile Gly Tyr Gly Arg Phe Phe Ile 
            340                 345                 350         


Ser Asn Pro Asp Leu Val Asp Arg Leu Glu Lys Gly Leu Pro Leu Asn 
        355                 360                 365             


Lys Tyr Asp Arg Asp Thr Phe Tyr Lys Met Ser Ala Glu Gly Tyr Ile 
    370                 375                 380                 


Asp Tyr Pro Thr Tyr Glu Glu Ala Leu Lys Leu Gly Trp Asp Lys Asn 
385                 390                 395                 400 


<210>  8
<211>  5474
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid encoding OYE3


<220>
<221>  CDS
<222>  (4)..(1203)

<400>  8
cat atg ccg ttt gtg aaa ggc ttt gaa ccg att agc ctg cgc gat acc       48
    Met Pro Phe Val Lys Gly Phe Glu Pro Ile Ser Leu Arg Asp Thr         
    1               5                   10                  15          

aac ctg ttt gaa ccg att aaa att ggc aac acc cag ctg gcg cat cgc       96
Asn Leu Phe Glu Pro Ile Lys Ile Gly Asn Thr Gln Leu Ala His Arg         
                20                  25                  30              

gcg gtg atg ccg ccg ctg acc cgc atg cgc gcg acc cat ccg ggc aac      144
Ala Val Met Pro Pro Leu Thr Arg Met Arg Ala Thr His Pro Gly Asn         
            35                  40                  45                  

att ccg aac aaa gaa tgg gcg gcg gtg tat tat ggc cag cgc gcg cag      192
Ile Pro Asn Lys Glu Trp Ala Ala Val Tyr Tyr Gly Gln Arg Ala Gln         
        50                  55                  60                      

cgc ccg ggc acc atg att att acc gaa ggc acc ttt att agc ccg cag      240
Arg Pro Gly Thr Met Ile Ile Thr Glu Gly Thr Phe Ile Ser Pro Gln         
    65                  70                  75                          

gcg ggc ggc tat gat aac gcg ccg ggc att tgg agc gat gaa cag gtg      288
Ala Gly Gly Tyr Asp Asn Ala Pro Gly Ile Trp Ser Asp Glu Gln Val         
80                  85                  90                  95          

gcg gaa tgg aaa aac att ttt ctg gcg att cat gat tgc cag agc ttt      336
Ala Glu Trp Lys Asn Ile Phe Leu Ala Ile His Asp Cys Gln Ser Phe         
                100                 105                 110             

gcg tgg gtg cag ctg tgg agc ctg ggc tgg gcg agc ttt ccg gat gtg      384
Ala Trp Val Gln Leu Trp Ser Leu Gly Trp Ala Ser Phe Pro Asp Val         
            115                 120                 125                 

ctg gcg cgc gat ggc ctg cgc tat gat tgc gcg agc gat cgc gtg tat      432
Leu Ala Arg Asp Gly Leu Arg Tyr Asp Cys Ala Ser Asp Arg Val Tyr         
        130                 135                 140                     

atg aac gcg acc ctg cag gaa aaa gcg aaa gat gcg aac aac ctg gaa      480
Met Asn Ala Thr Leu Gln Glu Lys Ala Lys Asp Ala Asn Asn Leu Glu         
    145                 150                 155                         

cat agc ctg acc aaa gat gat att aaa cag tat att aaa gat tat att      528
His Ser Leu Thr Lys Asp Asp Ile Lys Gln Tyr Ile Lys Asp Tyr Ile         
160                 165                 170                 175         

cat gcg gcg aaa aac agc att gcg gcg ggc gcg gat ggc gtg gaa att      576
His Ala Ala Lys Asn Ser Ile Ala Ala Gly Ala Asp Gly Val Glu Ile         
                180                 185                 190             

cat agc gcg aac ggc tat ctg ctg aac cag ttt ctg gat ccg cat agc      624
His Ser Ala Asn Gly Tyr Leu Leu Asn Gln Phe Leu Asp Pro His Ser         
            195                 200                 205                 

aac aaa cgc acc gat gaa tat ggc ggc acc att gaa aac cgc gcg cgc      672
Asn Lys Arg Thr Asp Glu Tyr Gly Gly Thr Ile Glu Asn Arg Ala Arg         
        210                 215                 220                     

ttt acc ctg gaa gtg gtg gat gcg ctg att gaa acc att ggc ccg gaa      720
Phe Thr Leu Glu Val Val Asp Ala Leu Ile Glu Thr Ile Gly Pro Glu         
    225                 230                 235                         

cgc gtg ggc ctg cgc ctg agc ccg tat ggc acc ttt aac agc atg agc      768
Arg Val Gly Leu Arg Leu Ser Pro Tyr Gly Thr Phe Asn Ser Met Ser         
240                 245                 250                 255         

ggc ggc gcg gaa ccg ggc att att gcg cag tat agc tat gtg ctg ggc      816
Gly Gly Ala Glu Pro Gly Ile Ile Ala Gln Tyr Ser Tyr Val Leu Gly         
                260                 265                 270             

gaa ctg gaa aaa cgc gcg aaa gcg ggc aaa cgc ctg gcg ttt gtg cat      864
Glu Leu Glu Lys Arg Ala Lys Ala Gly Lys Arg Leu Ala Phe Val His         
            275                 280                 285                 

ctg gtg gaa ccg cgc gtg acc gat ccg agc ctg gtg gaa ggc gaa ggc      912
Leu Val Glu Pro Arg Val Thr Asp Pro Ser Leu Val Glu Gly Glu Gly         
        290                 295                 300                     

gaa tat agc gaa ggc acc aac gat ttt gcg tat agc att tgg aaa ggc      960
Glu Tyr Ser Glu Gly Thr Asn Asp Phe Ala Tyr Ser Ile Trp Lys Gly         
    305                 310                 315                         

ccg att att cgc gcg ggc aac tat gcg ctg cat ccg gaa gtg gtg cgc     1008
Pro Ile Ile Arg Ala Gly Asn Tyr Ala Leu His Pro Glu Val Val Arg         
320                 325                 330                 335         

gaa cag gtg aaa gat ccg cgc acc ctg att ggc tat ggc cgc ttt ttt     1056
Glu Gln Val Lys Asp Pro Arg Thr Leu Ile Gly Tyr Gly Arg Phe Phe         
                340                 345                 350             

att agc aac ccg gat ctg gtg tat cgc ctg gaa gaa ggc ctg ccg ctg     1104
Ile Ser Asn Pro Asp Leu Val Tyr Arg Leu Glu Glu Gly Leu Pro Leu         
            355                 360                 365                 

aac aaa tat gat cgc agc acc ttt tat acc atg agc gcg gaa ggc tat     1152
Asn Lys Tyr Asp Arg Ser Thr Phe Tyr Thr Met Ser Ala Glu Gly Tyr         
        370                 375                 380                     

acc gat tat ccg acc tat gaa gaa gcg gtg gat ctg ggc tgg aac aaa     1200
Thr Asp Tyr Pro Thr Tyr Glu Glu Ala Val Asp Leu Gly Trp Asn Lys         
    385                 390                 395                         

aac aagcttggct gttttggcgg atgagagaag attttcagcc tgatacagat          1253
Asn                                                                     
400                                                                     

taaatcagaa cgcagaagcg gtctgataaa acagaatttg cctggcggca gtagcgcggt   1313

ggtcccacct gaccccatgc cgaactcaga agtgaaacgc cgtagcgccg atggtagtgt   1373

ggggtctccc catgcgagag tagggaactg ccaggcatca aataaaacga aaggctcagt   1433

cgaaagactg ggcctttcgt tttatctgtt gtttgtcggt gaacgctctc ctgagtagga   1493

caaatccgcc gggagcggat ttgaacgttg cgaagcaacg gcccggaggg tggcgggcag   1553

gacgcccgcc ataaactgcc aggcatcaaa ttaagcagaa ggccatcctg acggatggcc   1613

tttttgcgtt tctacaaact cttttgttta tttttctaaa tacattcaaa tatgtatccg   1673

ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaggaag agtatgagta   1733

ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg   1793

ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg   1853

gttacatcga actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac   1913

gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg   1973

acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt   2033

actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg   2093

ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac   2153

cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt   2213

gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag   2273

caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc   2333

aacaattaat agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc   2393

ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta   2453

tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg   2513

ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga   2573

ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac   2633

ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa   2693

tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat   2753

cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc   2813

taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg   2873

gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc   2933

acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg   2993

ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg   3053

ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa   3113

cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg   3173

aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga   3233

gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct   3293

gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca   3353

gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc   3413

ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg   3473

ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc   3533

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata tatggtgcac   3593

tctcagtaca atctgctctg atgccgcata gttaagccag tatacactcc gctatcgcta   3653

cgtgactggg tcatggctgc gccccgacac ccgccaacac ccgctgacgc gccctgacgg   3713

gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg gagctgcatg   3773

tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgaggc agctgcggta aagctcatca   3833

gcgtggtcgt gaagcgattc acagatgtct gcctgttcat ccgcgtccag ctcgttgagt   3893

ttctccagaa gcgttaatgt ctggcttctg ataaagcggg ccatgttaag ggcggttttt   3953

tcctgtttgg tcacttgatg cctccgtgta agggggaatt tctgttcatg ggggtaatga   4013

taccgatgaa acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt   4073

tactggaacg ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa   4133

tcactcaggg tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc   4193

agcagcatcc tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt   4253

ccagacttta cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg   4313

ttttgcagca gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag   4373

taaggcaacc ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc   4433

gtggccagga cccaacgctg cccgagatgc gccgcgtgcg gctgctggag atggcggacg   4493

cgatggatat gttctgccaa gggttggttt gcgcattcac agttctccgc aagaattgat   4553

tggctccaat tcttggagtg gtgaatccgt tagcgaggtg ccgccggctt ccattcaggt   4613

cgaggtggcc cggctccatg caccgcgacg caacgcgggg aggcagacaa ggtatagggc   4673

ggcgcctaca atccatgcca acccgttcca tgtgctcgcc gaggcggcat aaatcgccgt   4733

gacgatcagc ggtccagtga tcgaagttag gctggtaaga gccgcgagcg atccttgaag   4793

ctgtccctga tggtcgtcat ctacctgcct ggacagcatg gcctgcaacg cgggcatccc   4853

gatgccgccg gaagcgagaa gaatcataat ggggaaggcc atccagcctc gcgtcgcgaa   4913

cgccagcaag acgtagccca gcgcgtcggc cgccatgccg gcgataatgg cctgcttctc   4973

gccgaaacgt ttggtggcgg gaccagtgac gaaggcttga gcgagggcgt gcaagattcc   5033

gaataccgca agcgacaggc cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa   5093

aatgacccag agcgctgccg gcacctgtcc tacgagttgc atgataaaga agacagtcat   5153

aagtgcggcg acgatagtca tgccccgcgc ccaccggaag gagctgactg ggttgaaggc   5213

tctcaagggc atcggtcgac gctctccctt atgcgactcc tgcattagga agcagcccag   5273

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca tcgatcacca   5333

caattcagca aattgtgaac atcatcacgt tcatctttcc ctggttgcca atggcccatt   5393

ttcctgtcag taacgagaag gtcgcgaatt caggcgcttt ttagactggt cgtaatgaac   5453

aattcttaag aaggagatat a                                             5474


<210>  9
<211>  400
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  9

Met Pro Phe Val Lys Gly Phe Glu Pro Ile Ser Leu Arg Asp Thr Asn 
1               5                   10                  15      


Leu Phe Glu Pro Ile Lys Ile Gly Asn Thr Gln Leu Ala His Arg Ala 
            20                  25                  30          


Val Met Pro Pro Leu Thr Arg Met Arg Ala Thr His Pro Gly Asn Ile 
        35                  40                  45              


Pro Asn Lys Glu Trp Ala Ala Val Tyr Tyr Gly Gln Arg Ala Gln Arg 
    50                  55                  60                  


Pro Gly Thr Met Ile Ile Thr Glu Gly Thr Phe Ile Ser Pro Gln Ala 
65                  70                  75                  80  


Gly Gly Tyr Asp Asn Ala Pro Gly Ile Trp Ser Asp Glu Gln Val Ala 
                85                  90                  95      


Glu Trp Lys Asn Ile Phe Leu Ala Ile His Asp Cys Gln Ser Phe Ala 
            100                 105                 110         


Trp Val Gln Leu Trp Ser Leu Gly Trp Ala Ser Phe Pro Asp Val Leu 
        115                 120                 125             


Ala Arg Asp Gly Leu Arg Tyr Asp Cys Ala Ser Asp Arg Val Tyr Met 
    130                 135                 140                 


Asn Ala Thr Leu Gln Glu Lys Ala Lys Asp Ala Asn Asn Leu Glu His 
145                 150                 155                 160 


Ser Leu Thr Lys Asp Asp Ile Lys Gln Tyr Ile Lys Asp Tyr Ile His 
                165                 170                 175     


Ala Ala Lys Asn Ser Ile Ala Ala Gly Ala Asp Gly Val Glu Ile His 
            180                 185                 190         


Ser Ala Asn Gly Tyr Leu Leu Asn Gln Phe Leu Asp Pro His Ser Asn 
        195                 200                 205             


Lys Arg Thr Asp Glu Tyr Gly Gly Thr Ile Glu Asn Arg Ala Arg Phe 
    210                 215                 220                 


Thr Leu Glu Val Val Asp Ala Leu Ile Glu Thr Ile Gly Pro Glu Arg 
225                 230                 235                 240 


Val Gly Leu Arg Leu Ser Pro Tyr Gly Thr Phe Asn Ser Met Ser Gly 
                245                 250                 255     


Gly Ala Glu Pro Gly Ile Ile Ala Gln Tyr Ser Tyr Val Leu Gly Glu 
            260                 265                 270         


Leu Glu Lys Arg Ala Lys Ala Gly Lys Arg Leu Ala Phe Val His Leu 
        275                 280                 285             


Val Glu Pro Arg Val Thr Asp Pro Ser Leu Val Glu Gly Glu Gly Glu 
    290                 295                 300                 


Tyr Ser Glu Gly Thr Asn Asp Phe Ala Tyr Ser Ile Trp Lys Gly Pro 
305                 310                 315                 320 


Ile Ile Arg Ala Gly Asn Tyr Ala Leu His Pro Glu Val Val Arg Glu 
                325                 330                 335     


Gln Val Lys Asp Pro Arg Thr Leu Ile Gly Tyr Gly Arg Phe Phe Ile 
            340                 345                 350         


Ser Asn Pro Asp Leu Val Tyr Arg Leu Glu Glu Gly Leu Pro Leu Asn 
        355                 360                 365             


Lys Tyr Asp Arg Ser Thr Phe Tyr Thr Met Ser Ala Glu Gly Tyr Thr 
    370                 375                 380                 


Asp Tyr Pro Thr Tyr Glu Glu Ala Val Asp Leu Gly Trp Asn Lys Asn 
385                 390                 395                 400 


