
 Supplementary Table 9

 S. aureus vs S. pneumoniae; class comparison results: Comparison of gene expression levels (normalized values)
 between patients with acute S. aureus infection and patients with acute S.pneumoniae infection - P<0.01, Mann-
 Whitney test = 127 genes.  Expression patterns are represented supplementary Figure 2c.


                               Affymetrix                                 Fold          S.aureus (n=12)         S.pneumoniae (n=11)
 Common         GenBank        Probe ID       uniGeneI     P-value       Sa/Sp       Median     Min    Max     Median    Min     Max

 RAC2           NM_002872      207419_s_at    Hs.51760     0.000        0.717685828  0.5928    0.592  1.045    1.0951   0.898   1.368

 BBP            AA012917       213882_at      Hs.27687     0.000        0.620776434  0.3738    0.373  1.189    1.2531   0.855   2.397

 ZNF313         NM_018683      200868_s_at    Hs.14494     0.000        1.348934482  0.8243    0.824  1.503    0.8067   0.709   1.112

 PHKB           BG149218       202738_s_at    Hs.78060     0.000        0.734751000  0.6641    0.664  1.225    1.1253   0.906   1.357

                AA827892       65588_at       Hs.40087     0.000        1.804566280  0.6593    0.659  1.810    0.7916   0.409   1.387

 FLJ11193       AI421192       203738_at      Hs.51924     0.000        0.713430280  0.6330    0.633  1.071    1.1302   0.797   1.276

 ARFIP1         AF124489       214483_s_at    Hs.41608     0.000        0.552772458  0.2810    0.281  1.591    1.3486   0.830   1.728

 G10            NM_003910      205690_s_at    Hs.38023     0.000        1.266197644  0.9050    0.905  1.517    0.8376   0.571   1.236

 PTK9           NM_002822      201745_at      Hs.18907     0.000        1.490769736  0.5978    0.597  1.532    0.7103   0.444   1.052

 KIAA0152       NM_014730      200617_at      Hs.50707     0.000        0.723861353  0.6403    0.640  1.433    1.2771   0.876   1.599

 RNF10          AL578551       208632_at      Hs.44279     0.000        1.558682397  0.6498    0.649  1.610    0.7825   0.381   1.256

                AI820796       217704_x_at    Hs.58526     0.000        2.775903750  0.3088    0.308  6.566    0.6693   0.331   1.518

 NDUFB8         NM_005004      201227_s_at    Hs.52321     0.000        1.212083339  0.9459    0.945  1.449    0.9573   0.759   1.150

 FLJ10246       NM_018038      220458_at      Hs.27427     0.000        1.497470481  0.7804    0.780  2.064    0.8162   0.255   1.508

 SELPLG         U02297         209880_s_at    Hs.12734     0.000        0.645218331  0.5432    0.543  1.531    1.2571   0.866   1.830

 UBL1           BC006462       211069_s_at    Hs.81424     0.000        1.142822790  0.8281    0.828  1.514    0.9554   0.788   1.102

 HSP70-4        NM_016299      219212_at      Hs.53416     0.000        1.378369411  0.8634    0.863  2.184    0.8715   0.721   1.265

 TACSTD2        J04152         202286_s_at    Hs.23582     0.000        0.264451663  0.1305    0.130  2.355    1.8584   0.656   6.301
 ; M1S1;
 EGP-1;
 GA733;
 TROP2;

 TSG101         NM_006292      201758_at      Hs.52351     0.000        1.288887969  0.8992    0.899  1.581    0.8480   0.551   1.236

 CD24           M58664         208651_x_at    Hs.37510     0.000        0.299664931  0.2860    0.286  3.683    1.8685   0.799   6.439

 SLC16A3        AL513917       202855_s_at    Hs.50076     0.001        0.505622551  0.1398    0.139  1.303    1.4740   0.628   3.817

 OAZ1           AF090094       215947_s_at    Hs.51607     0.001        1.157909126  0.9440    0.944  1.236    0.9233   0.591   1.116

 COX4I1         AW337510       213758_at      Hs.43341     0.001        1.568988182  0.5259    0.525  1.977    0.8209   0.163   1.252

 SAT            NM_002970      203455_s_at    Hs.28491     0.001        1.254655659  0.9007    0.900  1.585    0.8996   0.545   1.188

 LOC5696        NM_020213      219639_x_at    Hs.27024     0.001        1.385941038  0.7739    0.773  1.304    0.7602   0.608   1.071

 ARPC5L         NM_030978      220966_x_at    Hs.13249     0.001        1.540636752  0.5455    0.545  2.621    0.8533   0.415   1.343

 TFRC           BC001188       208691_at      Hs.52961     0.001        1.368817821  0.4868    0.486  1.567    0.8967   0.313   1.062

 CASP10         NM_001230      205467_at      Hs.5353      0.001        0.632830305  0.3830    0.383  1.251    1.2164   0.574   1.504

 C13orf12       NM_015932      217769_s_at    Hs.26874     0.001        1.282585252  0.8160    0.816  1.407    0.8627   0.711   1.172

 TNFSF5         NM_000074      207892_at      Hs.652       0.001        0.658233682  0.4129    0.412  1.481    1.1688   0.803   1.683

 BRD3           NM_007371      203825_at      Hs.52247     0.001        0.702571387  0.6148    0.614  1.160    1.2808   0.839   2.814

 CDV-1          W05463         64432_at       Hs.33312     0.001        1.693497485  0.6782    0.678  1.641    0.7307   0.355   1.289

 OPTN           NM_021980      202074_s_at    Hs.33270     0.001        1.414750172  0.7583    0.758  2.043    0.8347   0.407   1.112

                AW003091       64488_at       Hs.55755     0.001        1.991291264  0.6328    0.632  2.322    0.6496   0.383   1.569

 DUSP12         NM_007240      218576_s_at    Hs.41621     0.001        1.313153042  0.5463    0.546  1.561    0.8403   0.576   1.015

 NDUFA4         NM_002489      217773_s_at    Hs.50098     0.001        1.227295710  0.8365    0.836  1.536    0.9170   0.504   1.028

 HPCAL1         NM_002149      205462_s_at    Hs.46769     0.002        0.848803983  0.7966    0.796  1.253    1.1261   0.886   2.056

 PSMC1          NM_002802      204219_s_at    Hs.35665     0.002        1.185110732  0.7623    0.762  1.414    0.9358   0.775   1.025

 EI24           NM_004879      208289_s_at    Hs.34391     0.002        1.377670180  0.8320    0.832  1.891    0.8267   0.558   1.223

 ILF3;          AF147209       208931_s_at    Hs.46588     0.002        1.718759022  0.8311    0.831  2.196    0.8068   0.498   1.597
 MMP4;
 MPP4;
 NF90;
 NFAR;
 TCP80;
 DRBP76;
 NFAR-1;
 MPHOSP
 H4; NF-
 AT-90

 DNAJB6         AF080569       208810_at      Hs.49074     0.002        1.757659962  0.7390    0.739  1.975    0.7628   0.603   1.320

 UBE2B          AA877765       202334_s_at    Hs.38598     0.002        1.303480183  0.7789    0.778  1.415    0.8500   0.653   1.044

 HT021          NM_020685      219288_at      Hs.47166     0.003        1.521610959  0.7675    0.767  2.386    0.8303   0.500   1.305

 SCO2           NM_005138      205241_at      Hs.56740     0.003        1.680530335  0.5960    0.596  2.032    0.6611   0.253   1.367

 RAE1           U85943         211318_s_at    Hs.37169     0.003        1.407645517  0.7612    0.761  1.969    0.8468   0.806   1.187

 COQ7           AF032900       209746_s_at    Hs.15711     0.003        0.752204667  0.7670    0.767  1.135    1.1837   0.869   1.537

 SCML1          NM_006746      218793_s_at    Hs.10965     0.003        2.039952630  0.5272    0.527  2.143    0.5593   0.266   1.217

 HTCD37         AF123539       209586_s_at    Hs.78524     0.003        0.633834716  0.4996    0.499  1.337    1.2548   0.818   1.994

 PIGH           BC004100       209625_at      Hs.55349     0.003        1.277751119  0.8886    0.888  1.788    0.8954   0.583   1.274

 TEGT           AF033095       200803_s_at    Hs.35052     0.003        0.872522222  0.6243    0.624  1.273    1.0716   0.944   1.375

 BZW1           NM_014670      200777_s_at    Hs.35598     0.003        1.268257351  0.7446    0.744  1.660    0.9010   0.718   1.217

 CTSL           NM_001912      202087_s_at    Hs.41812     0.003        2.059118995  0.7624    0.762  9.677    0.7296   0.564   3.727

 HNRPH3         NM_021644      207127_s_at    Hs.49989     0.003        1.385463530  0.8446    0.844  1.661    0.8304   0.686   1.239

                N31716         44669_at       Hs.35646     0.003        0.680758808  0.4843    0.484  2.535    1.1339   0.790   2.103

 CDC42          BC003682       208728_s_at    Hs.46763     0.003        1.316996164  0.9274    0.927  1.551    0.8431   0.755   1.186

 CAMSAP1        BE222901       212711_at      Hs.52249     0.003        1.310983917  0.8741    0.874  2.350    0.8833   0.691   1.279

 CAPN1          NM_005186      200752_s_at    Hs.50284     0.003        0.746049388  0.6262    0.626  1.160    1.2838   0.796   1.673

 KIAA0561       AB011133       213045_at      Hs.46618     0.003        0.798856700  0.5198    0.519  1.339    1.0570   0.938   1.596

 SRP14          NM_003134      200007_at      Hs.53373     0.003        1.146689209  0.8449    0.844  1.380    0.9096   0.821   1.037

 SNRPB2         NM_003092      202505_at      Hs.28037     0.003        1.437143543  0.9387    0.938  1.445    0.8051   0.523   1.442

 PFTK1          NM_012395      204604_at      Hs.43074     0.005        0.743678151  0.6197    0.619  1.277    1.1198   0.790   1.671

 CD24           AA761181       209771_x_at    Hs.37510     0.005        0.179926488  0.1376    0.137  2.114    2.2850   0.402   8.645

 NEK4           NM_003157      204634_at      Hs.12955     0.005        0.657591415  0.3706    0.370  1.533    1.2369   0.880   2.344

 YWHAQ          NM_006826      200693_at      Hs.74405     0.005        1.112755855  0.7992    0.799  1.381    0.9329   0.654   1.049

 CUL2           U83410         203078_at      Hs.82919     0.005        1.272192498  0.9027    0.902  1.866    0.9378   0.438   1.555

 PTCRA          AL035587       215492_x_at    Hs.16900     0.005        0.646230768  0.3540    0.354  1.485    1.0667   0.810   1.587

 SELPLG         AI741056       209879_at      Hs.12734     0.005        0.672958633  0.6484    0.648  1.135    1.3346   0.711   1.473

 RNGTT          AB012142       204207_s_at    Hs.56737     0.005        0.657388750  0.6346    0.634  1.570    1.3190   0.794   1.779

 CD24           BG327863       208650_s_at    Hs.37510     0.005        0.254824013  0.1876    0.187  2.315    1.7554   0.354   10.08

 CLN2           AA602532       214196_s_at    Hs.52345     0.005        0.743658178  0.4671    0.467  1.324    1.2567   0.746   1.723

 NFKBIE         NM_004556      203927_at      Hs.45827     0.005        1.309025249  0.6554    0.655  1.649    0.8982   0.523   1.452

 NDUFS3         NM_004551      201740_at      Hs.50252     0.005        1.274563602  0.7560    0.756  1.275    0.8884   0.647   1.154

 CIR            U03644         209571_at      Hs.47067     0.005        1.494380146  0.8681    0.868  1.794    0.8493   0.720   1.512

                               AFFX-r2-Ec-    ---          0.005        1.432121544  0.6516    0.651  1.482    0.8595   0.590   1.140
                               bioB-M_at

 TFG            NM_006070      217839_at      Hs.51812     0.005        1.306543645  0.8184    0.818  1.718    0.9375   0.649   1.210

 HLA-E          NM_005516      200905_x_at    Hs.38100     0.005        1.221512347  0.8804    0.880  1.350    0.9155   0.796   1.124

 DC13           NM_020188      218447_at      Hs.38825     0.005        1.255239586  0.8018    0.801  2.165    0.9202   0.824   1.082

 DGAT1          NM_012079      203669_s_at    Hs.52195     0.005        0.686043772  0.4928    0.492  1.233    1.1858   0.866   1.399

 HSPC111        BE314601       214011_s_at    Hs.52947     0.005        1.338436959  0.8627    0.862  1.526    0.8677   0.720   1.328

 NBS1           NM_002485      202907_s_at    Hs.49220     0.006        0.771921418  0.6960    0.696  1.296    1.1475   0.900   1.490

 HMOX2          D21243         218120_s_at    Hs.28427     0.006        0.794486399  0.4656    0.465  1.170    1.0723   0.600   1.405

 PTMA           BF686442       200772_x_at    Hs.45992     0.006        1.327177668  0.7909    0.790  1.798    0.8269   0.639   1.227

 TAX1BP1        NM_006024      200976_s_at    Hs.34576     0.006        1.170640900  0.8714    0.871  1.136    0.9081   0.709   1.094

 MAGED2         AI924630       213627_at      Hs.52266     0.006        1.363322954  0.5358    0.535  1.729    0.8126   0.494   1.061

 DHPS           NM_001930      202802_at      Hs.79064     0.006        0.674582947  0.4991    0.499  1.222    1.2175   0.730   1.391

 ADCK2          N32831         221893_s_at    Hs.53414     0.006        0.745828270  0.4786    0.478  1.410    1.1559   0.837   1.327

 CD24           X69397         209772_s_at    Hs.37510     0.006        0.227929556  0.0328    0.032  1.962    1.4398   0.272   8.433

 HRB            AI742626       213926_s_at    Hs.35296     0.006        0.719798742  0.4362    0.436  1.614    1.1088   0.76    2.872

 PKIG           NM_007066      202732_at      Hs.47283     0.006        0.816549807  0.5020    0.502  1.554    1.1236   0.886   1.362

 SPG4           NM_014946      207724_s_at    Hs.46809     0.006        0.707821648  0.5565    0.556  1.351    1.1065   0.725   1.791

 ELAVL1         BC003376       201726_at      Hs.18449     0.006        0.799492788  0.5587    0.558  1.099    1.1503   0.844   1.288

 UBE2D3         BF448062       200667_at      Hs.51877     0.006        1.193949407  0.9556    0.955  1.539    0.9111   0.703   1.416

 RAB1A          BC000905       208724_s_at    Hs.31064     0.006        1.262293724  0.8671    0.867  1.554    0.8952   0.680   1.442

 LOC5714        BE963444       203897_at      Hs.18548     0.006        1.151406183  0.7816    0.781  1.571    0.8973   0.690   1.016

 SF3A3          NM_006802      203818_s_at    Hs.77897     0.006        1.165141220  0.8267    0.826  1.209    0.9294   0.634   1.167

 GALNT11        NM_022087      219013_at      Hs.32997     0.006        1.298751708  0.8155    0.815  1.456    0.8645   0.555   1.220

 KIAA0830       AL573201       212573_at      Hs.16711     0.006        0.669748287  0.4986    0.498  1.191    1.1730   0.660   1.476

 HNRPH3         AF132363       210110_x_at    Hs.49989     0.006        1.235797506  0.7689    0.768  1.692    0.8922   0.522   1.156

 RNASEH         NM_002936      218497_s_at    Hs.50276     0.006        1.337310379  0.6681    0.668  1.360    0.9061   0.592   1.120

 NaGLT1;        AK000168       216379_x_at    Hs.37510     0.006        0.167724625  0.1393    0.139  2.103    2.3023   0.386   10.35
 KIAA1919
 ;

 H41            AK025647       212010_s_at    Hs.51826     0.008        1.153728642  0.8799    0.879  1.636    0.8976   0.649   1.080

 UBE2L3         NM_003347      200684_s_at    Hs.10810     0.008        0.643954118  0.3440    0.344  1.083    1.2063   0.636   1.911

 CAPN3          BC003169       210944_s_at    Hs.14326     0.008        0.716856318  0.6173    0.617  1.724    1.2840   0.912   3.230

 SS18L2         NM_016305      218283_at      Hs.53445     0.008        1.328869550  0.8374    0.837  1.467    0.8535   0.698   1.341

 CGI-43         AL550875       201973_s_at    Hs.53000     0.008        1.278083879  0.6575    0.657  1.335    0.8383   0.757   1.011

 SORL1          NM_003105      203509_at      Hs.36859     0.008        0.745325964  0.6481    0.648  1.441    1.0977   0.845   1.726

 EZH2           NM_004456      203358_s_at    Hs.44408     0.008        1.208437825  0.7453    0.745  1.645    0.9645   0.632   1.344

 SPIB           NM_003121      205861_at      Hs.43790     0.008        0.557915698  0.3303    0.330  2.945    1.4633   0.640   2.958

                AF333388       211456_x_at    Hs.56824     0.008        1.729616126  0.7342    0.734  8.285    0.8204   0.436   3.680

 COP9           BC003090       202141_s_at    Hs.53171     0.008        1.246724013  0.8336    0.833  1.677    0.9205   0.694   1.175

 SFRS3          AF107405       208673_s_at    Hs.40514     0.008        1.482913738  0.6981    0.698  1.838    0.7601   0.657   1.235

 KIAA0703       AW291664       214798_at      Hs.6168      0.008        0.673913031  0.4104    0.410  1.367    1.1459   0.799   3.338

 SNRPA1         AJ130972       216977_x_at    Hs.52876     0.008        1.573209699  0.6628    0.662  2.592    0.8347   0.658   1.441

 YWHAQ          AA854017       213699_s_at    Hs.74405     0.008        1.204444709  0.9057    0.905  1.591    0.9342   0.635   1.211

 NDUFC2         NM_004549      218101_s_at    Hs.40786     0.008        1.236698544  0.8268    0.826  1.490    0.8694   0.762   1.115

 TLE3           AI567426       212770_at      Hs.28736     0.008        1.948565918  0.4403    0.440  2.343    0.6835   0.387   1.556

 LRRC5          NM_018103      218684_at      Hs.48208     0.008        0.746100906  0.6427    0.642  1.343    1.2209   0.484   1.639

                               AFFX-r2-Ec-    ---          0.008        1.462380818  0.7123    0.712  1.377    0.7284   0.415   1.275
                               bioB-3_at

 SLC16A3        NM_004207      202856_s_at    Hs.50076     0.008        0.378219595  0.1891    0.189  1.605    1.6712   0.553   4.737

 TNRC11         NM_005120      203506_s_at    Hs.40922     0.008        0.796044080  0.5132    0.513  1.166    1.0738   0.602   2.093

 PPP1R7         BF718769       213465_s_at    Hs.36587     0.008        1.297112972  0.8368    0.836  1.719    0.9079   0.698   1.173

 UBE2L3         NM_003347      200682_s_at    Hs.10810     0.008        1.115371617  0.8886    0.888  1.353    0.9852   0.822   1.100

 WBSCR5         AF257135       221581_s_at    Hs.56607     0.008        0.787657875  0.4388    0.438  1.699    1.1390   0.968   1.746

 MUS81          NM_025128      218463_s_at    Hs.28879     0.008        0.760786788  0.6298    0.629  1.218    1.1871   0.688   1.517

                BC000265       209435_s_at    Hs.51679     0.008        0.796080748  0.6725    0.672  1.417    1.1354   0.707   1.535

 DAPK3          BF686824       203890_s_at    Hs.23330     0.008        0.711591542  0.2812    0.281  1.471    1.1448   0.755   1.908

 OSBPL10        NM_017784      219073_s_at    Hs.15012     0.008        0.681796189  0.4689    0.468  1.671    1.2139   0.528   3.953




























